Entity
IL-2Ralpha
--
G010230
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m93219
10
infinite
0
TRANSFAC | G010230 |
--
A20
--
G010405
cso30:c:mRNA
cso30:i:CC_CellComponent
--
csml-variable:Double
m93378
10
infinite
0
TRANSFAC | G010405 |
--
NF-kappaB
--
MO000000058
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m11
10
infinite
0
TRANSPATH | MO000000058 |
--
IKK-alpha
--
MO000000210
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m181
10
infinite
0
InterPro | IPR000719 |
TRANSPATH | MO000000210 |
--
IkappaB-alpha
--
MO000000233
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m199
10
infinite
0
InterPro | IPR002110 |
TRANSPATH | MO000000233 |
--
TNF-alpha
--
MO000000289
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m230
10
infinite
0
InterPro | IPR003636 |
TRANSPATH | MO000000289 |
--
IL-1beta
--
MO000016597
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m1591
10
infinite
0
TRANSPATH | MO000016597 |
--
IL-2
--
MO000017061
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m1954
10
infinite
0
TRANSPATH | MO000017061 |
--
IL-2Ralpha
--
MO000017214
cso30:c:Protein
cso30:i:CC_CellComponent
--
--
csml-variable:Double
m2080
10
infinite
0
InterPro | IPR006209 |
TRANSPATH | MO000017214 |
--
NADPH oxidase
--
MO000021432
cso30:c:Protein
cso30:i:CC_CellComponent
--
--
csml-variable:Double
m5783
10
infinite
0
TRANSPATH | MO000021432 |
--
--
e1
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane
--
--
--
csml-variable:Double
m1
0
infinite
0
--
--
e10
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytosol
--
--
--
csml-variable:Double
m10
0
infinite
0
--
NF-kappaB{active}
--
e11
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m12
10
infinite
0
TRANSPATH | MO000000058 |
--
IkappaB-alpha{p}
--
e12
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m13
10
infinite
0
InterPro | IPR002110 |
TRANSPATH | MO000000233 |
--
PMA
--
e13
cso30:c:SmallMolecule
cso30:i:CC_Cytosol
--
csml-variable:Double
m14
0
infinite
0
--
PHA-p
--
e14
cso30:c:SmallMolecule
cso30:i:CC_Cytosol
--
csml-variable:Double
m15
0
infinite
0
--
IkappaB-alpha{ub}
--
e16
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m17
10
infinite
0
InterPro | IPR002110 |
TRANSPATH | MO000000233 |
--
NF-kappaB{active}
--
e17
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m18
10
infinite
0
TRANSPATH | MO000000058 |
--
csml-variable:Double
m19
0
infinite
0
--
NF-KappaB{active}:DNA
--
e19
cso30:c:Complex
cso30:i:CC_Nucleoplasm
--
--
csml-variable:Double
m20
0
infinite
0
--
--
e2
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m2
0
infinite
0
--
p105
--
e20
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
--
csml-variable:Double
m21
0
infinite
0
--
O2
--
e21
cso30:c:SmallMolecule
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m22
0
infinite
0
--
O2-
--
e22
cso30:c:SmallMolecule
cso30:i:CC_Cytosol
--
csml-variable:Double
m23
0
infinite
0
--
Metallothionein
--
e23
cso30:c:SmallMolecule
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m24
0
infinite
0
--
Hydroxyl group
--
e24
cso30:c:SmallMolecule
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m25
0
infinite
0
--
Iron
--
e25
cso30:c:SmallMolecule
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m26
0
infinite
0
--
H2O2
--
e26
cso30:c:SmallMolecule
cso30:i:CC_Cytosol
--
csml-variable:Double
m27
0
infinite
0
--
Copper
--
e27
cso30:c:SmallMolecule
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m28
0
infinite
0
--
ROS
--
e28
cso30:c:SmallMolecule
cso30:i:CC_Cytosol
--
csml-variable:Double
m29
0
infinite
0
--
csml-variable:Double
m30
0
infinite
0
--
--
e3
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
--
csml-variable:Double
m3
0
infinite
0
--
Epstein Barr protein
--
e30
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m31
0
infinite
0
--
Thymulin
--
e31
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m32
0
infinite
0
--
High affinity receptors
--
e32
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m33
0
infinite
0
--
Thymulin:High affinity receptors
--
e33
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m34
0
infinite
0
--
T-cell marker
--
e34
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
--
csml-variable:Double
m35
0
infinite
0
--
Super oxide dismutase
--
e35
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m36
0
infinite
0
--
Thymocytes
--
e36
cso30:c:Cell
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m37
0
infinite
0
--
peripheral T-lymphocytes
--
e37
cso30:c:Cell
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m38
0
infinite
0
--
Peripheral B-lymphocytes
--
e38
cso30:c:Cell
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m39
0
infinite
0
--
--
e4
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m4
0
infinite
0
--
Zinc
--
e5
cso30:c:SmallMolecule
cso30:i:CC_Cytosol
--
csml-variable:Double
m5
0
infinite
0
--
--
e50
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelopeLumen
--
--
--
csml-variable:Double
m50
0
infinite
0
--
--
e51
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearPore
--
--
--
csml-variable:Double
m51
0
infinite
0
--
--
e52
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearInnerMembrane
--
--
--
csml-variable:Double
m52
0
infinite
0
--
--
e53
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearLumen
--
--
--
csml-variable:Double
m53
0
infinite
0
--
--
e54
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearOuterMembrane
--
--
--
csml-variable:Double
m54
0
infinite
0
--
--
e55
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleus
--
--
--
csml-variable:Double
m55
0
infinite
0
--
--
e56
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleoplasm
--
--
--
csml-variable:Double
m56
0
infinite
0
--
--
e57
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearBody
--
--
--
csml-variable:Double
m57
0
infinite
0
--
--
e58
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleolus
--
--
--
csml-variable:Double
m58
0
infinite
0
--
--
e59
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelope
--
--
--
csml-variable:Double
m59
0
infinite
0
--
MHC class I
--
e6
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
--
csml-variable:Double
m6
0
infinite
0
--
--
e60
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Chromatin
--
--
--
csml-variable:Double
m60
0
infinite
0
--
--
e61
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearChromosome
--
--
--
csml-variable:Double
m61
0
infinite
0
--
--
e62
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearCentromere
--
--
--
csml-variable:Double
m62
0
infinite
0
--
--
e7
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell
--
--
--
csml-variable:Double
m7
0
infinite
0
--
--
e8
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell_WithoutCellWall_
--
--
--
csml-variable:Double
m8
0
infinite
0
--
--
e9
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytoplasm
--
--
--
csml-variable:Double
m9
0
infinite
0
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c3 : 1
stoichiometry:c2 : 1
m93423*m5*0.1
nodelay
--
0
PMID: 18385818,9280142,9227444 Our studies in the experimental human model showed for the first time that the production of IFN-gamma was decreased, whereas the production of IL-4, IL-6 and IL-10 was not affected due to zinc deficiency
p10
p10
cso30:i:ME_Ubiquitination
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c33 : 1
stoichiometry:c34 : 1
stoichiometry:c32 : 1
m199*m5*m14*0.1
nodelay
--
0
PMID: 18385818,11574819 Zinc deficiency caused a 50% reduction of ubiquitinated IKappaB-alpha after PMA/PHA-p stimulation
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c36 : 1
stoichiometry:c37 : 1
m15*m5*0.1
nodelay
--
0
PMID: 18385818,11574819 Zinc deficiency caused a 50% reduction of ubiquitinated IKappaB-alpha after PMA/PHA-p stimulation
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c39 : 1
m12*0.1
nodelay
--
0
PMID: 18385818,11574819 We showed that the phosphorylation of IKappaB and IKK, translocation of NF-KappaB, and its binding to DNA in HUT-78 cells were all zinc dependent
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1
stoichiometry:c42 : 1
m18*m19*0.1
nodelay
--
0
PMID: 18385818,11574819 We showed that the phosphorylation of IKappaB and IKK, translocation of NF-KappaB, and its binding to DNA in HUT-78 cells were all zinc dependent
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c44 : 1
m5*0.1
nodelay
--
0
PMID: 18385818,11574819 We showed that the phosphorylation of IKappaB and IKK, translocation of NF-KappaB, and its binding to DNA in HUT-78 cells were all zinc dependent
p15
p15
cso30:i:ME_UnknownProduction
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c46 : 1
stoichiometry:c48 : 1
stoichiometry:c47 : 1
m5783*m22*0.1
nodelay
--
0
PMID: 18385818 The NADPH oxidases are a group of plasma membrane associated enzymes, which catalyze the production of O2.¡Ý from oxygen by using NADPH as the electron donor. PMID: 18385818 Zinc is an inhibitor of this enzyme
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c50 : 1
m5*0.1
nodelay
--
0
PMID: 18385818 Zinc is known to induce the production of metallothionein, which is very rich in cysteine, and is an excellent scavenger of .OH
p17
p17
cso30:i:ME_UnknownProduction
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c53 : 1
stoichiometry:c54 : 1
stoichiometry:c55 : 1
stoichiometry:c52 : 1
m27*m26*m28*0.1
nodelay
--
0
PMID: 18385818 Iron and copper ions catalyze the production of .OH from H2O2. PMID: 18385818 Zinc is known to compete with both iron and copper for binding to cell membrane, thus decreasing the production of .OH
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c57 : 1
m230*0.1
nodelay
--
0
PMID: 18385818,3500253,2824615 A few investigators have reported that inflammatory cytokines such as TNF-alpha (tumor necrosis factor-alpha) and IL-1beta, generated by activated monocytes-macrophages, also are known to produce increased amounts of ROS
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c59 : 1
m1591*0.1
nodelay
--
0
PMID: 18385818,3500253,2824615 A few investigators have reported that inflammatory cytokines such as TNF-alpha (tumor necrosis factor-alpha) and IL-1beta, generated by activated monocytes-macrophages, also are known to produce increased amounts of ROS
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
m5*0.1
nodelay
--
0
PMID: 18385818 IFN- gamma is the major component of the Th1 response panel, and it upregulates major histocompatibility complex class I antigen expression.
p20
p20
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c61 : 1
stoichiometry:c69 : 1
stoichiometry:c62 : 1
m230*m11*0.1
nodelay
--
0
PMID: 18385818,2118515,1381359,9928991,8557994, One such inhibitor of NF-KappaB activation is A20, a zinc finger-transactivating factor which also binds to DNA, producing the A20 protein which inhibits TNF-alpha-induced NF-KappaB activation
p21
p21
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c64 : 1
stoichiometry:c65 : 1
stoichiometry:c70 : 1
stoichiometry:c66 : 1
m1591*m11*0.1
nodelay
--
0
PMID: 18385818, 2118515,1381359,9928991,8557994 A20 plays an important role in reducing IL-1beta- and TNF-alpha-induced NF-kappaB activation
p22
p22
cso30:i:ME_DNABinding
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c63 : 1
stoichiometry:c67 : 1
stoichiometry:c75 : 1
stoichiometry:c68 : 1
m1585*m19*m5*0.1
nodelay
--
0
PMID: 18385818, 2118515,1381359,9928991,8557994, One such inhibitor of NF-KappaB activation is A20, a zinc finger-transactivating factor which also binds to DNA, producing the A20 protein which inhibits TNF-alpha-induced NF-KappaB activation. PMID: 18385818,15451058 In addition, we provided evidence to show that, in the human pro-myelocytic leukemia cell line HL-60 which differentiates to the monocyte-macrophage phenotype by PMA, zinc increased the expression of A20 and the binding of A20 transactivating factor to DNA, thereby enhancing inhibition of induced NF-KappaB activation
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c71 : 1
1.0*0.1
nodelay
--
0
PMID: 18385818 Our data showed that zinc supplementation to normal healthy subjects inhibits the induction of TNF-alpha and IL-1beta mRNA in MNCs
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c73 : 1
1.0*0.1
nodelay
--
0
PMID: 18385818 Our data showed that zinc supplementation to normal healthy subjects inhibits the induction of TNF-alpha and IL-1beta mRNA in MNCs
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c77 : 1
m5*0.1
nodelay
--
0
PMID: 18385818,15451058 In addition, we provided evidence to show that, in the human pro-myelocytic leukemia cell line HL-60 which differentiates to the monocyte-macrophage phenotype by PMA, zinc increased the expression of A20 and the binding of A20 transactivating factor to DNA, thereby enhancing inhibition of induced NF-KappaB activation
p26
p26
cso30:i:ME_GeneExpression
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c78 : 1
stoichiometry:c79 : 1
m230*0.1
nodelay
--
0
PMID: 18385818,8557994 A20 is expressed in various types of cells in response to a number of stimuli such as TNF-alpha, IL-1beta, LPS (lipopolysaccharide), PMA, Epstein-Barr virus latent membrane protein, as well as other stimuli
p26
p27
cso30:i:ME_GeneExpression
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c80 : 1
stoichiometry:c81 : 1
m1591*0.1
nodelay
--
0
PMID: 18385818,8557994 A20 is expressed in various types of cells in response to a number of stimuli such as TNF-alpha, IL-1beta, LPS (lipopolysaccharide), PMA, Epstein-Barr virus latent membrane protein, as well as other stimuli
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c83 : 1
m14*0.1
nodelay
--
0
PMID: 18385818,8557994 A20 is expressed in various types of cells in response to a number of stimuli such as TNF-alpha, IL-1beta, LPS (lipopolysaccharide), PMA, Epstein-Barr virus latent membrane protein, as well as other stimuli
p25
p29
cso30:i:ME_GeneExpression
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c85 : 1
m155666*0.1
nodelay
--
0
PMID: 18385818,15451058 In addition, we provided evidence to show that, in the human pro-myelocytic leukemia cell line HL-60 which differentiates to the monocyte-macrophage phenotype by PMA, zinc increased the expression of A20 and the binding of A20 transactivating factor to DNA, thereby enhancing inhibition of induced NF-KappaB activation
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c6 : 1
stoichiometry:c7 : 1
m93218*0.1
nodelay
--
0
PMID: 18385818 Because zinc deficiency affects IL-2 production and T-cell activation adversely, we have investigated the role of zinc on NF-KappaB (nuclear factor-kappaB) activation in HUT-78, a T helper 0 (Th0) human malignant lymphoblastoid cell line.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c87 : 1
m31*0.1
nodelay
--
0
PMID: 18385818,15451058 In addition, we provided evidence to show that, in the human pro-myelocytic leukemia cell line HL-60 which differentiates to the monocyte-macrophage phenotype by PMA, zinc increased the expression of A20 and the binding of A20 transactivating factor to DNA, thereby enhancing inhibition of induced NF-KappaB activation
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c88 : 1
stoichiometry:c89 : 1
stoichiometry:c90 : 1
m32*m33*0.1
nodelay
--
0
PMID: 18385818 Thymulin binds to high-affinity receptors on T cells, induces several T-cell markers, and promotes T-cell function, including allogenic cytotoxicity, suppressor functions, and interleukin-2 (IL-2) production.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c91 : 1
stoichiometry:c92 : 1
m34*0.1
nodelay
--
0
PMID: 18385818 Thymulin binds to high-affinity receptors on T cells, induces several T-cell markers, and promotes T-cell function, including allogenic cytotoxicity, suppressor functions, and interleukin-2 (IL-2) production.
p33
p33
cso30:i:ME_Translation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c95 : 1
stoichiometry:c94 : 1
m93218*m34*0.1
nodelay
--
0
PMID: 18385818 Thymulin binds to high-affinity receptors on T cells, induces several T-cell markers, and promotes T-cell function, including allogenic cytotoxicity, suppressor functions, and interleukin-2 (IL-2) production.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c96 : 1
stoichiometry:c97 : 1
stoichiometry:c98 : 1
m36*m23*0.1
nodelay
--
0
PMID: 18385818 The dismutation of O2.¡Ýto H2O2 is catalyzed by an enzyme super oxide dismutase (SOD), which contains both copper and zinc.
p35
p35
cso30:i:CE_CellDifferentiation
cso30:i:CC_Extracellular
--
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c100 : 1
m1954*m37*0.1
nodelay
--
0
PMID: 18385818,7548205 IL-2 also is involved in the differentiation of thymocytes, peripheral T- and B-lymphocytes and other cells of hematopoietic origin
p35
p36
cso30:i:CE_CellDifferentiation
cso30:i:CC_Extracellular
--
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c101 : 1
stoichiometry:c102 : 1
m1954*m38*0.1
nodelay
--
0
PMID: 18385818,7548205 IL-2 also is involved in the differentiation of thymocytes, peripheral T- and B-lymphocytes and other cells of hematopoietic origin
p35
p37
cso30:i:CE_CellDifferentiation
cso30:i:CC_Extracellular
--
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c103 : 1
stoichiometry:c104 : 1
m1954*m39*0.1
nodelay
--
0
PMID: 18385818,7548205 IL-2 also is involved in the differentiation of thymocytes, peripheral T- and B-lymphocytes and other cells of hematopoietic origin
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c105 : 1
stoichiometry:c107 : 1
stoichiometry:c106 : 1
m14*m5*0.1
nodelay
--
0
PMID: 18385818,12389026 Following PMA/PHA-p stimulation, the IL-2 production and IL-2 mRNA were significantly greater in zinc-sufficient cells in comparison to the zinc-deficient cells
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c8 : 1
stoichiometry:c108 : 1
stoichiometry:c109 : 1
m5*m15*0.1
nodelay
--
0
PMID: 18385818,12389026 Following PMA/PHA-p stimulation, the IL-2 production and IL-2 mRNA were significantly greater in zinc-sufficient cells in comparison to the zinc-deficient cells
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c9 : 1
stoichiometry:c10 : 1
stoichiometry:c11 : 1
m5*m11*0.1
nodelay
--
0
PMID: 18385818,11574819 We showed for the first time that, in zinc deficient HUT-78 cells, the activation of NF-KappaB was affected adversely
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c110 : 1
stoichiometry:c111 : 1
m93219*0.1
nodelay
--
0
PMID: 18385818,12389026 Similar results were seen for soluble IL-2 receptor alpha (soluble IL-2Ralpha) production and gene expression
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c112 : 1
stoichiometry:c114 : 1
stoichiometry:c113 : 1
m5*m14*0.1
nodelay
--
0
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c116 : 1
stoichiometry:c117 : 1
stoichiometry:c115 : 1
m5*m15*0.1
nodelay
--
0
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c119 : 1
stoichiometry:c118 : 1
m18*0.1
nodelay
--
0
PMID: 18385818,9619918,2785715 Induction of IL-2Ralphagene expression also is mediated by the induced nuclear expression of NF-KappaB
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c12 : 1
stoichiometry:c13 : 1
stoichiometry:c14 : 1
m5*m199*0.1
nodelay
--
0
PMID: 18385818 Zinc deficiency caused a 60percent decrease in phosphorylated IKappaB-alpha in non-stimulated and 40percent decrease in phorbol-12 myristate 13 acetate (PMA)/phytohemagglutinin-p (PHA-p)?stimulated cells, compared with zinc-sufficient cells PMID: 18385818,11574819 We showed that the phosphorylation of IKappaB and IKK, translocation of NF-KappaB, and its binding to DNA in HUT-78 cells were all zinc dependent
p5
p6
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c16 : 1
stoichiometry:c18 : 1
stoichiometry:c17 : 1
m14*m5*m199*0.1
nodelay
--
0
PMID: 18385818 Zinc deficiency caused a 60percent decrease in phosphorylated IKappaB-alpha in non-stimulated and 40percent decrease in phorbol-12 myristate 13 acetate (PMA)/phytohemagglutinin-p (PHA-p)?stimulated cells, compared with zinc-sufficient cells PMID: 18385818,11574819 We showed that the phosphorylation of IKappaB and IKK, translocation of NF-KappaB, and its binding to DNA in HUT-78 cells were all zinc dependent
p5
p7
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1
stoichiometry:c22 : 1
m15*m5*m199*0.1
nodelay
--
0
PMID: 18385818 Zinc deficiency caused a 60percent decrease in phosphorylated IKappaB-alpha in non-stimulated and 40percent decrease in phorbol-12 myristate 13 acetate (PMA)/phytohemagglutinin-p (PHA-p)?stimulated cells, compared with zinc-sufficient cells PMID: 18385818,11574819 We showed that the phosphorylation of IKappaB and IKK, translocation of NF-KappaB, and its binding to DNA in HUT-78 cells were all zinc dependent
p8
p8
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c24 : 1
stoichiometry:c28 : 1
stoichiometry:c25 : 1
m14*m181*m5*0.1
nodelay
--
0
PMID: 18385818 Zinc deficiency decreased IKK- alpha in PMA/PHA-p?stimulated cells by 30percent in comparison to zinc-sufficient cells. PMID: 18385818,11574819 We showed that the phosphorylation of IKappaB and IKK, translocation of NF-KappaB, and its binding to DNA in HUT-78 cells were all zinc dependent
p8
p9
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c26 : 1
stoichiometry:c29 : 1
stoichiometry:c30 : 1
stoichiometry:c27 : 1
m181*m5*m15*0.1
nodelay
--
0
PMID: 18385818 Zinc deficiency decreased IKK- alpha in PMA/PHA-p?stimulated cells by 30percent in comparison to zinc-sufficient cells. PMID: 18385818,11574819 We showed that the phosphorylation of IKappaB and IKK, translocation of NF-KappaB, and its binding to DNA in HUT-78 cells were all zinc dependent
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--