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Interestingly, TLR4 could also be activated by endogenous ligands produced during stress or cell damage, including heat-shock protein 60, ED-A domain of fibronectin, and hyaluronan</csml:comment>
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Interestingly, TLR4 could also be activated by endogenous ligands produced during stress or cell damage, including heat-shock protein 60, ED-A domain of fibronectin, and hyaluronan</csml:comment>
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Interestingly, TLR4 could also be activated by endogenous ligands produced during stress or cell damage, including heat-shock protein 60, ED-A domain of fibronectin, and hyaluronan</csml:comment>
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Constitutive NF-κB activation, often observed in cancer cells, may be promoted by either microenvironmental signals, including cytokines, hypoxia, and reactive oxygen intermediates (ROI), or by genetic alterations</csml:comment>
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Constitutive NF-κB activation, often observed in cancer cells, may be promoted by either microenvironmental signals, including cytokines, hypoxia, and reactive oxygen intermediates (ROI), or by genetic alterations</csml:comment>
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In particular, pro-inflammatory cytokines (e.g. IL-1 and TNF), expressed by infiltrating leukocytes, can activate NF-κB in cancer cells and contribute to their proliferation and survival</csml:comment>
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In particular, pro-inflammatory cytokines (e.g. IL-1 and TNF), expressed by infiltrating leukocytes, can activate NF-κB in cancer cells and contribute to their proliferation and survival</csml:comment>
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There is now evidence that TIR8, an orphan member of the IL-1R family (also known as single immunoglobulin IL-1R-related molecule, SIGIRR) inhibits signalling from the IL-1R/TLR complexes, possibly by trapping IRAK-1 and TRAF-6</csml:comment>
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Tir8 gene transfer experiments have revealed that it reduces NF-κB activation by the IL-1R complex ,as well as by members of the TLR family such as TLR4
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Transfer of activated ras oncogene into a cervical carcinoma line (HeLa) induces IL-8/CXCL8 production that is sufficient to promote angiogenesis and tumor progression</csml:comment>
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Transfer of activated ras oncogene into a cervical carcinoma line (HeLa) induces IL-8/CXCL8 production that is sufficient to promote angiogenesis and tumor progression</csml:comment>
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Braf, frequently activated in malignant melanoma, induces cytokine production that contributes to pro-tumor milieu</csml:comment>
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TAM contribute to tumor progression and invasion also by expressing molecules that directly affect tumor cell proliferation and dissolution of connective tissues. These include epidermal growth factor (EGF), members of the FGF family, TGFβ, VEGF, chemokines, and cytokines</csml:comment>
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TAM contribute to tumor progression and invasion also by expressing molecules that directly affect tumor cell proliferation and dissolution of connective tissues. These include epidermal growth factor (EGF), members of the FGF family, TGFβ, VEGF, chemokines, and cytokines</csml:comment>
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TAM contribute to tumor progression and invasion also by expressing molecules that directly affect tumor cell proliferation and dissolution of connective tissues. These include epidermal growth factor (EGF), members of the FGF family, TGFβ, VEGF, chemokines, and cytokines</csml:comment>
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TAM contribute to tumor progression and invasion also by expressing molecules that directly affect tumor cell proliferation and dissolution of connective tissues. These include epidermal growth factor (EGF), members of the FGF family, TGFβ, VEGF, chemokines, and cytokines</csml:comment>
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TAM contribute to tumor progression and invasion also by expressing molecules that directly affect tumor cell proliferation and dissolution of connective tissues. These include epidermal growth factor (EGF), members of the FGF family, TGFβ, VEGF, chemokines, and cytokines</csml:comment>
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TAM contribute to tumor progression and invasion also by expressing molecules that directly affect tumor cell proliferation and dissolution of connective tissues. These include epidermal growth factor (EGF), members of the FGF family, TGFβ, VEGF, chemokines, and cytokines

PMID: 18325755
TAM produce several matrix metalloproteases (e.g. MMP2, MMP9) and activators of MMPs, such as chemokines.</csml:comment>
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TAM produce several matrix metalloproteases (e.g. MMP2, MMP9) and activators of MMPs, such as chemokines.</csml:comment>
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<csml:comment type="text">PMID: 18325755
TAM produce several matrix metalloproteases (e.g. MMP2, MMP9) and activators of MMPs, such as chemokines.</csml:comment>
</csml:comments>
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<csml:comment type="text">PMID: 18325755,7547226
TAM also produce factors, such as TGFβ, PDGF, IL-6, urokinase plasminogen activator, and tissue-type plasminogen activator (t-PA) that may cause matrix degradation </csml:comment>
</csml:comments>
</csml:process>
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<csml:comment type="text">PMID: 18325755,7547226
TAM also produce factors, such as TGFβ, PDGF, IL-6, urokinase plasminogen activator, and tissue-type plasminogen activator (t-PA) that may cause matrix degradation </csml:comment>
</csml:comments>
</csml:process>
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<csml:comments>
<csml:comment type="text">PMID: 18325755,7547226
TAM also produce factors, such as TGFβ, PDGF, IL-6, urokinase plasminogen activator, and tissue-type plasminogen activator (t-PA) that may cause matrix degradation </csml:comment>
</csml:comments>
</csml:process>
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<csml:comments>
<csml:comment type="text">PMID: 18325755,7547226
TAM also produce factors, such as TGFβ, PDGF, IL-6, urokinase plasminogen activator, and tissue-type plasminogen activator (t-PA) that may cause matrix degradation </csml:comment>
</csml:comments>
</csml:process>
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<csml:comment type="text">indirect</csml:comment>
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<csml:comments>
<csml:comment type="text">PMID: 18325755
Chemokines have been shown to induce gene expression of various MMPs and, in particular, MMP-9 production, along with the uPA receptor</csml:comment>
</csml:comments>
</csml:process>
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In normal macrophages CCL18 is inducible by Th2 cytokines: IL-4, IL-13, and IL-10 and recruit naive T cells by interacting with an unidentified receptor</csml:comment>
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In normal macrophages CCL18 is inducible by Th2 cytokines: IL-4, IL-13, and IL-10 and recruit naive T cells by interacting with an unidentified receptor</csml:comment>
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In normal macrophages CCL18 is inducible by Th2 cytokines: IL-4, IL-13, and IL-10 and recruit naive T cells by interacting with an unidentified receptor</csml:comment>
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Two other chemokines, CCL17 and CCL22, are abundantly expressed by TAM </csml:comment>
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Two other chemokines, CCL17 and CCL22, are abundantly expressed by TAM </csml:comment>
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These chemokines interact with the CCR4 receptor, expressed mostly by Th2 cells and by Treg </csml:comment>
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These chemokines interact with the CCR4 receptor, expressed mostly by Th2 cells and by Treg </csml:comment>
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In particular, the RET/PTC1 oncogene activated transcriptome profile includes CSFs, which promote leukocyte recruitment and survival; IL-1, a primary inflammatory cytokine; the inflammatory mediator COX2; chemokines attracting monocytes and dendritic cells (CCL2, CCL20; angiogenic chemokines; coordinate induction and inhibition of matrix degrading enzymes and inhibitors; l-selectin; and CXCR4.</csml:comment>
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In particular, the RET/PTC1 oncogene activated transcriptome profile includes CSFs, which promote leukocyte recruitment and survival; IL-1, a primary inflammatory cytokine; the inflammatory mediator COX2; chemokines attracting monocytes and dendritic cells (CCL2, CCL20; angiogenic chemokines; coordinate induction and inhibition of matrix degrading enzymes and inhibitors; l-selectin; and CXCR4.</csml:comment>
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In particular, the RET/PTC1 oncogene activated transcriptome profile includes CSFs, which promote leukocyte recruitment and survival; IL-1, a primary inflammatory cytokine; the inflammatory mediator COX2; chemokines attracting monocytes and dendritic cells (CCL2, CCL20; angiogenic chemokines; coordinate induction and inhibition of matrix degrading enzymes and inhibitors; l-selectin; and CXCR4.</csml:comment>
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In particular, the RET/PTC1 oncogene activated transcriptome profile includes CSFs, which promote leukocyte recruitment and survival; IL-1, a primary inflammatory cytokine; the inflammatory mediator COX2; chemokines attracting monocytes and dendritic cells (CCL2, CCL20; angiogenic chemokines; coordinate induction and inhibition of matrix degrading enzymes and inhibitors; l-selectin; and CXCR4.</csml:comment>
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