Entity
IL-12 p40
--
G010657
cso30:c:mRNA
cso30:i:CC_CellComponent
--
csml-variable:Double
m93589
10
infinite
0
TRANSFAC | G010657 |
--
TNF-alpha
--
MO000000289
cso30:c:Protein
cso30:i:CC_CellComponent
--
--
csml-variable:Double
m230
10
infinite
0
InterPro | IPR003636 |
TRANSPATH | MO000000289 |
--
IFN Type I
--
MO000016658
cso30:c:Protein
cso30:i:CC_CellComponent
--
--
csml-variable:Double
m1634
10
infinite
0
TRANSPATH | MO000016658 |
--
CD14
--
MO000018132
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m2828
10
infinite
0
InterPro | IPR001611 |
TRANSPATH | MO000018132 |
--
TLR3
--
MO000019398
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m3965
10
infinite
0
InterPro | IPR000157 |
TRANSPATH | MO000019398 |
--
TLR9
--
MO000042012
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m19828
10
infinite
0
TRANSPATH | MO000042012 |
--
TLR7
--
MO000042126
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m19940
10
infinite
0
TRANSPATH | MO000042126 |
--
--
e1
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane
--
--
--
csml-variable:Double
m1
0
infinite
0
--
--
e10
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytosol
--
--
--
csml-variable:Double
m10
0
infinite
0
--
--
e11
cso30:c:EntityBiologicalCompartment
cso30:i:CC_EndosomeMembrane
--
--
--
csml-variable:Double
m11
0
infinite
0
--
--
e12
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Endosome
--
--
--
csml-variable:Double
m12
0
infinite
0
--
TLR1: TLR2
--
e13
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m13
0
infinite
0
--
TLR2: TLR6
--
e14
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m14
0
infinite
0
--
endosomal ssRNA
--
e15
cso30:c:Rna
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m15
0
infinite
0
--
ssRNA: TLR7
--
e16
cso30:c:Complex
cso30:i:CC_EndosomeLumen
--
--
csml-variable:Double
m16
0
infinite
0
--
csml-variable:Double
m17
0
infinite
0
--
endosomal DNA: TLR9
--
e18
cso30:c:Complex
cso30:i:CC_EndosomeMembrane
--
--
csml-variable:Double
m18
0
infinite
0
--
RIG-1
--
e19
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m19
0
infinite
0
--
--
e2
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m2
0
infinite
0
--
ssRNA: RIG-1
--
e20
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m20
0
infinite
0
--
ssRNA{cytoplasmic}
--
e21
cso30:c:Rna
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m21
0
infinite
0
--
dsRNA: MDA-5
--
e23
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m23
0
infinite
0
--
csml-variable:Double
m24
0
infinite
0
--
DNA: DAI
--
e25
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m25
0
infinite
0
--
microbial membrane lipid
--
e26
cso30:c:Protein
cso30:i:CC_Extracellular
--
csml-variable:Double
m26
0
infinite
0
--
microbial membrane lipid: TLR1: TLR2
--
e27
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m27
0
infinite
0
--
microbial membrane lipid: TLR2: TLR6
--
e28
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m28
0
infinite
0
--
microbial membrane lipid: TLR4: MD-2
--
e29
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m29
0
infinite
0
--
--
e3
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
--
csml-variable:Double
m3
0
infinite
0
--
microbial nucleic acid
--
e30
cso30:c:SmallMolecule
cso30:i:CC_Extracellular
--
csml-variable:Double
m30
0
infinite
0
--
microbial nucleic acid: TLR3
--
e31
cso30:c:Complex
cso30:i:CC_EndosomeLumen
--
csml-variable:Double
m31
0
infinite
0
--
microbial nucleic acid: TLR7
--
e32
cso30:c:Complex
cso30:i:CC_EndosomeLumen
--
csml-variable:Double
m32
0
infinite
0
--
microbial nucleic acid: TLR8
--
e33
cso30:c:Complex
cso30:i:CC_EndosomeLumen
--
csml-variable:Double
m33
0
infinite
0
--
microbial nucleic acid: TLR9
--
e34
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m34
0
infinite
0
--
cytokine
--
e35
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m35
0
infinite
0
--
Unc93B
--
e36
cso30:c:Protein
cso30:i:CC_EndoplasmicReticulum_Membrane_
--
csml-variable:Double
m36
0
infinite
0
--
Unc93B: TLR3
--
e37
cso30:c:Complex
cso30:i:CC_EndosomeMembrane
--
--
csml-variable:Double
m37
0
infinite
0
--
Unc93B: TLR7
--
e38
cso30:c:Complex
cso30:i:CC_EndosomeLumen
--
--
csml-variable:Double
m38
0
infinite
0
--
Unc93B: TLR9
--
e39
cso30:c:Complex
cso30:i:CC_EndosomeMembrane
--
--
csml-variable:Double
m39
0
infinite
0
--
--
e4
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m4
0
infinite
0
--
Unc93B: TLR13
--
e40
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m40
0
infinite
0
--
--
e41
cso30:c:EntityBiologicalCompartment
cso30:i:CC_EndoplasmicReticulum
--
--
--
csml-variable:Double
m41
0
infinite
0
--
--
e42
cso30:c:EntityBiologicalCompartment
cso30:i:CC_EndoplasmicReticulumLumen
--
--
--
csml-variable:Double
m42
0
infinite
0
--
--
e43
cso30:c:EntityBiologicalCompartment
cso30:i:CC_EndoplasmicReticulum_ExtrinsicToExternalSideOfMembrane_
--
--
--
csml-variable:Double
m43
0
infinite
0
--
--
e44
cso30:c:EntityBiologicalCompartment
cso30:i:CC_EndoplasmicReticulum_Membrane_
--
--
--
csml-variable:Double
m44
0
infinite
0
--
--
e45
cso30:c:EntityBiologicalCompartment
cso30:i:CC_EndoplasmicReticulum_ExtrinsicToInternalSideOfMembrane_
--
--
--
csml-variable:Double
m45
0
infinite
0
--
--
e46
cso30:c:EntityBiologicalCompartment
cso30:i:CC_EndoplasmicReticulum_IntegralToMembrane_
--
--
--
csml-variable:Double
m46
0
infinite
0
--
PRAT4A
--
e48
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m48
0
infinite
0
--
csml-variable:Double
m49
0
infinite
0
--
TLR4: MD-2
--
e5
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m5
0
infinite
0
--
--
e50
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelopeLumen
--
--
--
csml-variable:Double
m50
0
infinite
0
--
--
e51
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearPore
--
--
--
csml-variable:Double
m51
0
infinite
0
--
--
e52
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearInnerMembrane
--
--
--
csml-variable:Double
m52
0
infinite
0
--
--
e53
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearLumen
--
--
--
csml-variable:Double
m53
0
infinite
0
--
--
e54
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearOuterMembrane
--
--
--
csml-variable:Double
m54
0
infinite
0
--
--
e55
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleus
--
--
--
csml-variable:Double
m55
0
infinite
0
--
--
e56
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleoplasm
--
--
--
csml-variable:Double
m56
0
infinite
0
--
--
e57
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearBody
--
--
--
csml-variable:Double
m57
0
infinite
0
--
--
e58
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleolus
--
--
--
csml-variable:Double
m58
0
infinite
0
--
--
e59
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelope
--
--
--
csml-variable:Double
m59
0
infinite
0
--
--
e6
cso30:c:EntityBiologicalCompartment
cso30:i:CC_EndosomeLumen
--
--
--
csml-variable:Double
m6
0
infinite
0
--
--
e60
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Chromatin
--
--
--
csml-variable:Double
m60
0
infinite
0
--
--
e61
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearChromosome
--
--
--
csml-variable:Double
m61
0
infinite
0
--
--
e62
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearCentromere
--
--
--
csml-variable:Double
m62
0
infinite
0
--
PRAT4A
--
e63
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
--
csml-variable:Double
m63
0
infinite
0
--
csml-variable:Double
m64
0
infinite
0
--
HGMB: DNA{nuclear}
--
e65
cso30:c:Complex
cso30:i:CC_Nucleoplasm
--
--
csml-variable:Double
m65
0
infinite
0
--
csml-variable:Double
m66
0
infinite
0
--
DNA: BCR
--
e67
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m68
0
infinite
0
--
DNA associated autoantigens: TLR9
--
e68
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m69
0
infinite
0
--
DNA associated autoantigens
--
e69
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m70
0
infinite
0
--
--
e7
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell
--
--
--
csml-variable:Double
m7
0
infinite
0
--
csml-variable:Double
m71
0
infinite
0
--
HGMB1: DNA: TLR9
--
e71
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m72
0
infinite
0
--
RNA
--
e72
cso30:c:Rna
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m73
0
infinite
0
--
RNA: BCR
--
e73
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m74
0
infinite
0
--
RNA associated autoantigens
--
e74
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m75
0
infinite
0
--
RNA associated autoantigens: TLR7
--
e75
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m76
0
infinite
0
--
IFNalpha
--
e76
cso30:c:mRNA
cso30:i:CC_Nucleolus
--
--
csml-variable:Double
m77
0
infinite
0
--
--
e77
cso30:c:EntityBiologicalCompartment
cso30:i:CC_EndoplasmicReticulumLumen
--
--
--
csml-variable:Double
m78
0
infinite
0
--
--
e78
cso30:c:EntityBiologicalCompartment
cso30:i:CC_EndoplasmicReticulum_IntegralToMembrane_
--
--
--
csml-variable:Double
m79
0
infinite
0
--
--
e79
cso30:c:EntityBiologicalCompartment
cso30:i:CC_EndoplasmicReticulum_ExtrinsicToExternalSideOfMembrane_
--
--
--
csml-variable:Double
m80
0
infinite
0
--
--
e8
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell_WithoutCellWall_
--
--
--
csml-variable:Double
m8
0
infinite
0
--
--
e80
cso30:c:EntityBiologicalCompartment
cso30:i:CC_EndoplasmicReticulum_ExtrinsicToInternalSideOfMembrane_
--
--
--
csml-variable:Double
m81
0
infinite
0
--
--
e81
cso30:c:EntityBiologicalCompartment
cso30:i:CC_EndoplasmicReticulum_Membrane_
--
--
--
csml-variable:Double
m82
0
infinite
0
--
--
e82
cso30:c:EntityBiologicalCompartment
cso30:i:CC_EndoplasmicReticulum
--
--
--
csml-variable:Double
m83
0
infinite
0
--
--
e9
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytoplasm
--
--
--
csml-variable:Double
m9
0
infinite
0
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1
m19940*m15*0.1
nodelay
--
0
PMID: 18321608, 11095740, 11812998, 11607032 Endosomal ssRNA, dsRNA, and DNA are recognized by TLR7, TLR3, and TLR9, respectively[3], [4] and [5].
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c35 : 1
stoichiometry:c39 : 1
m30*m3965*0.1
nodelay
--
0
PMID: 18321608 Cell surface TLRs, including TLR4/MD-2, TLR1/TLR2, and TLR6/TLR2, recognize microbial membrane lipids, whereas TLR3, TLR7/8, and TLR9 reside in intracellular organelles and recognize microbial nucleic acids.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1
stoichiometry:c36 : 1
stoichiometry:c43 : 1
m30*m19940*0.1
nodelay
--
0
PMID: 18321608 Cell surface TLRs, including TLR4/MD-2, TLR1/TLR2, and TLR6/TLR2, recognize microbial membrane lipids, whereas TLR3, TLR7/8, and TLR9 reside in intracellular organelles and recognize microbial nucleic acids.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c33 : 1
stoichiometry:c37 : 1
stoichiometry:c41 : 1
m30*m19823*0.1
nodelay
--
0
PMID: 18321608 Cell surface TLRs, including TLR4/MD-2, TLR1/TLR2, and TLR6/TLR2, recognize microbial membrane lipids, whereas TLR3, TLR7/8, and TLR9 reside in intracellular organelles and recognize microbial nucleic acids.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c38 : 1
stoichiometry:c42 : 1
m30*m19828*0.1
nodelay
--
0
PMID: 18321608 Cell surface TLRs, including TLR4/MD-2, TLR1/TLR2, and TLR6/TLR2, recognize microbial membrane lipids, whereas TLR3, TLR7/8, and TLR9 reside in intracellular organelles and recognize microbial nucleic acids.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c52 : 1
m34*0.1
nodelay
--
0
PMID: 18321608, 15995707 A synergistic relationship between TLR3/4 and TLR7/8/9 has been recently reported in the triggering of IL-12 and other Th1-promoting cytokines by DCs.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c51 : 1
m33*0.1
nodelay
--
0
PMID: 18321608, 15995707 A synergistic relationship between TLR3/4 and TLR7/8/9 has been recently reported in the triggering of IL-12 and other Th1-promoting cytokines by DCs.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c50 : 1
m32*0.1
nodelay
--
0
PMID: 18321608, 15995707 A synergistic relationship between TLR3/4 and TLR7/8/9 has been recently reported in the triggering of IL-12 and other Th1-promoting cytokines by DCs.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c49 : 1
m31*0.1
nodelay
--
0
PMID: 18321608, 15995707 A synergistic relationship between TLR3/4 and TLR7/8/9 has been recently reported in the triggering of IL-12 and other Th1-promoting cytokines by DCs.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c53 : 1
m28*0.1
nodelay
--
0
PMID: 18321608, 15995707 A synergistic relationship between TLR3/4 and TLR7/8/9 has been recently reported in the triggering of IL-12 and other Th1-promoting cytokines by DCs.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c48 : 1
stoichiometry:c54 : 1
m29*0.1
nodelay
--
0
PMID: 18321608, 15995707 A synergistic relationship between TLR3/4 and TLR7/8/9 has been recently reported in the triggering of IL-12 and other Th1-promoting cytokines by DCs.
p2
p2
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c69 : 1
stoichiometry:c3 : 1
m3965*m119368*m2828*0.1
nodelay
--
0
PMID: 18321608, 11095740, 11812998, 11607032 Endosomal ssRNA, dsRNA, and DNA are recognized by TLR7, TLR3, and TLR9, respectively[3], [4] and [5]. PMID: 18321608, 16473828 Recently, cell surface CD14 was reported to enhance TLR3 response as well by upregulating cellular uptake of dsRNA.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c55 : 1
m34*0.1
nodelay
--
0
PMID: 18321608, 15995707 A synergistic relationship between TLR3/4 and TLR7/8/9 has been recently reported in the triggering of IL-12 and other Th1-promoting cytokines by DCs.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c56 : 1
m33*0.1
nodelay
--
0
PMID: 18321608, 15995707 A synergistic relationship between TLR3/4 and TLR7/8/9 has been recently reported in the triggering of IL-12 and other Th1-promoting cytokines by DCs.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c57 : 1
m32*0.1
nodelay
--
0
PMID: 18321608, 15995707 A synergistic relationship between TLR3/4 and TLR7/8/9 has been recently reported in the triggering of IL-12 and other Th1-promoting cytokines by DCs.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1
stoichiometry:c58 : 1
m31*0.1
nodelay
--
0
PMID: 18321608, 15995707 A synergistic relationship between TLR3/4 and TLR7/8/9 has been recently reported in the triggering of IL-12 and other Th1-promoting cytokines by DCs.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c63 : 1
m28*0.1
nodelay
--
0
PMID: 18321608, 15995707 A synergistic relationship between TLR3/4 and TLR7/8/9 has been recently reported in the triggering of IL-12 and other Th1-promoting cytokines by DCs.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c66 : 1
stoichiometry:c64 : 1
m29*0.1
nodelay
--
0
PMID: 18321608, 15995707 A synergistic relationship between TLR3/4 and TLR7/8/9 has been recently reported in the triggering of IL-12 and other Th1-promoting cytokines by DCs.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1
stoichiometry:c67 : 1
m1634*0.1
nodelay
--
0
PMID: 18321608 Selective regulation by type I IFN of TLR7 expression is likely to contribute to autoantibody production and autoimmunity.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1
stoichiometry:c71 : 1
stoichiometry:c74 : 1
m3965*m36*0.1
nodelay
--
0
PMID: 18321608 Unc93B specifically interacts with TLR3, 7, 9, and 13.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c77 : 1
stoichiometry:c75 : 1
m36*m19940*0.1
nodelay
--
0
PMID: 18321608 Unc93B specifically interacts with TLR3, 7, 9, and 13.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c78 : 1
stoichiometry:c76 : 1
m36*m19828*0.1
nodelay
--
0
PMID: 18321608 Unc93B specifically interacts with TLR3, 7, 9, and 13.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1
m19828*m17*0.1
nodelay
--
0
PMID: 18321608, 11095740, 11812998, 11607032 Endosomal ssRNA, dsRNA, and DNA are recognized by TLR7, TLR3, and TLR9, respectively[3], [4] and [5].
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c80 : 1
stoichiometry:c81 : 1
m36*m19948*0.1
nodelay
--
0
PMID: 18321608 Unc93B specifically interacts with TLR3, 7, 9, and 13.
p31
p31
cso30:i:ME_Translation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c86 : 1
stoichiometry:c82 : 1
m93614*m48*0.1
nodelay
--
0
PMID: 18321608 Cell surface expression of TLR4 was apparently downregulated by PRAT4A knockdown, demonstrating that PRAT4A serves as a chaperone for TLR4.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c87 : 1
stoichiometry:c85 : 1
m47*m48*0.1
nodelay
--
0
PMID: 18321608, 17998391, 14716310 TLR9 resides in the ER and traffics to endosome/lysosome for ligand recognition [22]. TLR9 in PRAT4A-silenced cells is unable to traffic to endosome/lysosome.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c89 : 1
stoichiometry:c88 : 1
1.0*0.1
nodelay
--
0
PMID: 18321608 Interestingly, expression of PRAT4A mRNA in bone marrow-derived dendritic cells is downregulated by stimulation with TLR ligands such as lipid A.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c90 : 1
stoichiometry:c91 : 1
stoichiometry:c92 : 1
m64*m22603*0.1
nodelay
--
0
PMID: 18321608, 16813837 The high-mobility group box (HMGB) proteins are highly abundant chromatin-binding proteins located mainly in the cell nucleus, where they bind to the minor groove of DNA.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c94 : 1
stoichiometry:c95 : 1
m67*m66*0.1
nodelay
--
0
PMID: 18321608, 11948342 DNA and DNA-associated autoantigens activate autoreactive B cells via sequential engagement of the B cell antigen receptor (BCR) and TLR9.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c96 : 1
stoichiometry:c98 : 1
stoichiometry:c97 : 1
m19828*m70*0.1
nodelay
--
0
PMID: 18321608, 11948342 DNA and DNA-associated autoantigens activate autoreactive B cells via sequential engagement of the B cell antigen receptor (BCR) and TLR9.
p37
p37
cso30:i:ME_Binding
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c100 : 1
stoichiometry:c101 : 1
m19828*m71*0.1
nodelay
--
0
PMID: 18321608, 17548579 HMGB1 was identified as molecule that binds to a TLR9 ligand CpG. HMGB1 accelerates the delivery of CpG-ODNs to its receptor, leading to a TLR9-dependent augmentation of IL-6, IL-12, and TNFalpha secretion.
p38
p38
cso30:i:ME_Translation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c102 : 1
stoichiometry:c103 : 1
stoichiometry:c104 : 1
m93589*m72*0.1
nodelay
--
0
PMID: 18321608, 17548579 HMGB1 was identified as molecule that binds to a TLR9 ligand CpG. HMGB1 accelerates the delivery of CpG-ODNs to its receptor, leading to a TLR9-dependent augmentation of IL-6, IL-12, and TNFalpha secretion.
p39
p39
cso30:i:ME_Translation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c109 : 1
stoichiometry:c105 : 1
m93248*m72*0.1
nodelay
--
0
PMID: 18321608, 17548579 HMGB1 was identified as molecule that binds to a TLR9 ligand CpG. HMGB1 accelerates the delivery of CpG-ODNs to its receptor, leading to a TLR9-dependent augmentation of IL-6, IL-12, and TNFalpha secretion.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1
m19*m21*0.1
nodelay
--
0
PMID: 18321608, 15208624, 17618271, 16625202 Cytoplasmic ssRNA, dsRNA, and DNA are sensed by retinoic acid inducible gene I (RIG-1), melanoma associated gene 5 (MDA5), and DNA-dependent activator of IFN-regulatory factors (DAI), respectively.
p40
p40
cso30:i:ME_Translation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c108 : 1
stoichiometry:c110 : 1
stoichiometry:c107 : 1
m93309*m72*0.1
nodelay
--
0
PMID: 18321608, 17548579 HMGB1 was identified as molecule that binds to a TLR9 ligand CpG. HMGB1 accelerates the delivery of CpG-ODNs to its receptor, leading to a TLR9-dependent augmentation of IL-6, IL-12, and TNFalpha secretion.
p41
p41
cso30:i:ME_Binding
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c111 : 1
stoichiometry:c112 : 1
stoichiometry:c113 : 1
m73*m67*0.1
nodelay
--
0
PMID: 18321608, 16260486 Similarly, RNA and RNA-associated autoantigens activate B cells by engaging BCR and TLR7.
p42
p42
cso30:i:ME_Binding
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c114 : 1
stoichiometry:c115 : 1
stoichiometry:c116 : 1
m75*m19940*0.1
nodelay
--
0
PMID: 18321608, 16260486 Similarly, RNA and RNA-associated autoantigens activate B cells by engaging BCR and TLR7.
PMID: 18321608, 15815647, 16864658 Recent studies have suggested that TLR9 signaling in early endosomes leads to IFN-alpha production by pDCs, whereas TLR9 signaling in late endosomes induces pDC maturation, IL-6 and TNF-alpha secretion.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c118 : 1
stoichiometry:c120 : 1
stoichiometry:c119 : 1
m77*m34*0.1
nodelay
--
0
PMID: 18321608, 15815647, 16864658 Recent studies have suggested that TLR9 signaling in early endosomes leads to IFN-alpha production by pDCs, whereas TLR9 signaling in late endosomes induces pDC maturation, IL-6 and TNF-alpha secretion.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1
m76904*m22*0.1
nodelay
--
0
PMID: 18321608, 15208624, 17618271, 16625202 Cytoplasmic ssRNA, dsRNA, and DNA are sensed by retinoic acid inducible gene I (RIG-1), melanoma associated gene 5 (MDA5), and DNA-dependent activator of IFN-regulatory factors (DAI), respectively.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1
m24*m36323*0.1
nodelay
--
0
PMID: 18321608, 15208624, 17618271, 16625202 Cytoplasmic ssRNA, dsRNA, and DNA are sensed by retinoic acid inducible gene I (RIG-1), melanoma associated gene 5 (MDA5), and DNA-dependent activator of IFN-regulatory factors (DAI), respectively.
p7
p7
cso30:i:ME_Binding
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c21 : 1
stoichiometry:c26 : 1
stoichiometry:c30 : 1
stoichiometry:c27 : 1
m26*m5*m2828*0.1
nodelay
--
0
PMID: 18321608 Cell surface TLRs, including TLR4/MD-2, TLR1/TLR2, and TLR6/TLR2, recognize microbial membrane lipids, whereas TLR3, TLR7/8, and TLR9 reside in intracellular organelles and recognize microbial nucleic acids. PMID: 18321608 Cell surface CD14 is known to augment cell surface TLRs such as TLR2 and TLR4/MD-2.
p8
p8
cso30:i:ME_Binding
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c20 : 1
stoichiometry:c22 : 1
stoichiometry:c29 : 1
stoichiometry:c23 : 1
m26*m14*m2828*0.1
nodelay
--
0
PMID: 18321608 Cell surface TLRs, including TLR4/MD-2, TLR1/TLR2, and TLR6/TLR2, recognize microbial membrane lipids, whereas TLR3, TLR7/8, and TLR9 reside in intracellular organelles and recognize microbial nucleic acids. PMID: 18321608 Cell surface CD14 is known to augment cell surface TLRs such as TLR2 and TLR4/MD-2.
p9
p9
cso30:i:ME_Binding
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c24 : 1
stoichiometry:c28 : 1
stoichiometry:c25 : 1
m26*m13*m2828*0.1
nodelay
--
0
PMID: 18321608 Cell surface TLRs, including TLR4/MD-2, TLR1/TLR2, and TLR6/TLR2, recognize microbial membrane lipids, whereas TLR3, TLR7/8, and TLR9 reside in intracellular organelles and recognize microbial nucleic acids. PMID: 18321608 Cell surface CD14 is known to augment cell surface TLRs such as TLR2 and TLR4/MD-2.
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--