Entity
MyD88
--
MO000016573
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m1572
10
infinite
0
InterPro | IPR000157 |
TRANSPATH | MO000016573 |
--
dsRNA:TLR3:TRIF
--
MO000041437
cso30:c:Protein
cso30:i:CC_CellComponent
--
--
csml-variable:Double
m19305
10
infinite
0
TRANSPATH | MO000041437 |
--
dsRNA:TLR3
--
MO000041446
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m19314
10
infinite
0
TRANSPATH | MO000041446 |
--
IRF-3{p}:IRF-3{p}
--
MO000088437
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m316590
10
infinite
0
TRANSFAC | T09392 |
TRANSPATH | MO000088437 |
--
--
e1
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane
--
--
--
csml-variable:Double
m1
0
infinite
0
--
L.monocytogenes
--
e10
cso30:c:Cell
cso30:i:CC_Cytoplasm
--
--
csml-variable:Double
m10
0
infinite
0
--
--
e11
cso30:c:EntityBiologicalCompartment
cso30:i:CC_EndosomeMembrane
--
--
--
csml-variable:Double
m11
0
infinite
0
--
ssRNA
--
e12
cso30:c:Rna
cso30:i:CC_Cytosol
--
csml-variable:Double
m12
0
infinite
0
--
ssRNA:TLR7
--
e13
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m13
0
infinite
0
--
ssRNA:TLR8
--
e14
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m14
0
infinite
0
--
CpG DNA
--
e16
cso30:c:Dna
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m16
0
infinite
0
--
TLR9:CpG DNA
--
e17
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m17
0
infinite
0
--
DDX58:dsRNA
--
e18
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m18
0
infinite
0
--
PKZ
--
e19
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
--
csml-variable:Double
m19
0
infinite
0
--
--
e2
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m2
0
infinite
0
--
Poly(rI:rC)
--
e20
cso30:c:SmallMolecule
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m20
0
infinite
0
--
DAI
--
e21
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m21
0
infinite
0
--
csml-variable:Double
m22
0
infinite
0
--
csml-variable:Double
m23
0
infinite
0
--
csml-variable:Double
m24
0
infinite
0
--
csml-variable:Double
m25
0
infinite
0
--
SmtB
--
e26
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m26
0
infinite
0
--
DAI:SmtB
--
e27
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m27
0
infinite
0
--
Mar
--
e28
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m28
0
infinite
0
--
DAI:Mar
--
e29
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m29
0
infinite
0
--
--
e3
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
--
csml-variable:Double
m3
0
infinite
0
--
ADARs
--
e30
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m30
0
infinite
0
--
SmtB:ADARs
--
e31
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m31
0
infinite
0
--
ADARs:Mar
--
e32
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m32
0
infinite
0
--
ADARs:dsRNA
--
e33
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m33
0
infinite
0
--
dsRNA:IFIH1
--
e34
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m34
0
infinite
0
--
ssRNA
--
e35
cso30:c:Rna
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m35
0
infinite
0
--
ssRNA:DDX58
--
e36
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m36
0
infinite
0
--
DLM-1
--
e37
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m37
0
infinite
0
--
IFN-alpha
--
e38
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m38
0
infinite
0
--
S.flexneri
--
e39
cso30:c:Cell
cso30:i:CC_Cytoplasm
--
--
csml-variable:Double
m39
0
infinite
0
--
--
e4
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m4
0
infinite
0
--
enterophathogenic e.coli
--
e40
cso30:c:Cell
cso30:i:CC_Cytoplasm
--
--
csml-variable:Double
m40
0
infinite
0
--
L.pnemophila
--
e41
cso30:c:Cell
cso30:i:CC_Cytoplasm
--
--
csml-variable:Double
m41
0
infinite
0
--
Type I IFN
--
e42
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m42
0
infinite
0
--
csml-variable:Double
m43
0
infinite
0
--
csml-variable:Double
m44
0
infinite
0
--
csml-variable:Double
m45
0
infinite
0
--
E3L:dsRNA
--
e46
cso30:c:Complex
cso30:i:CC_Cytoplasm
--
--
csml-variable:Double
m46
0
infinite
0
--
csml-variable:Double
m47
0
infinite
0
--
DAI:B-DNA:IRF-3:TBK1
--
e48
cso30:c:Complex
cso30:i:CC_Cytoplasm
--
csml-variable:Double
m48
0
infinite
0
--
IRF-3{p}:IRF-3{p}
--
e49
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m49
10
infinite
0
TRANSFAC | T09392 |
TRANSPATH | MO000088437 |
--
--
e5
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Endosome
--
--
--
csml-variable:Double
m5
0
infinite
0
--
--
e50
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelopeLumen
--
--
--
csml-variable:Double
m50
0
infinite
0
--
--
e51
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearPore
--
--
--
csml-variable:Double
m51
0
infinite
0
--
--
e52
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearInnerMembrane
--
--
--
csml-variable:Double
m52
0
infinite
0
--
--
e53
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearLumen
--
--
--
csml-variable:Double
m53
0
infinite
0
--
--
e54
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearOuterMembrane
--
--
--
csml-variable:Double
m54
0
infinite
0
--
--
e55
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleus
--
--
--
csml-variable:Double
m55
0
infinite
0
--
--
e56
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleoplasm
--
--
--
csml-variable:Double
m56
0
infinite
0
--
--
e57
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearBody
--
--
--
csml-variable:Double
m57
0
infinite
0
--
--
e58
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleolus
--
--
--
csml-variable:Double
m58
0
infinite
0
--
--
e59
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelope
--
--
--
csml-variable:Double
m59
0
infinite
0
--
--
e6
cso30:c:EntityBiologicalCompartment
cso30:i:CC_EndosomeLumen
--
--
--
csml-variable:Double
m6
0
infinite
0
--
--
e60
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Chromatin
--
--
--
csml-variable:Double
m60
0
infinite
0
--
--
e61
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearChromosome
--
--
--
csml-variable:Double
m61
0
infinite
0
--
--
e62
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearCentromere
--
--
--
csml-variable:Double
m62
0
infinite
0
--
IFN-alpha
--
e63
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
--
csml-variable:Double
m63
0
infinite
0
--
DDX58:dsRNA:MAVS
--
e64
cso30:c:Complex
cso30:i:CC_Cytoplasm
--
csml-variable:Double
m64
0
infinite
0
--
TLr9:CpG DNA:MyD88
--
e65
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m65
0
infinite
0
--
ssRNA:TLR8:MyD88
--
e66
cso30:c:Complex
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m66
0
infinite
0
--
ssRNA:TLR7:MyD88
--
e67
cso30:c:Complex
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m67
0
infinite
0
--
IFIH1:dsRNA:MAVS
--
e68
cso30:c:Complex
cso30:i:CC_Cytoplasm
--
--
csml-variable:Double
m68
0
infinite
0
--
Atg5:Atg12
--
e69
cso30:c:Complex
cso30:i:CC_Cytoplasm
--
--
csml-variable:Double
m69
0
infinite
0
--
--
e7
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell
--
--
--
csml-variable:Double
m7
0
infinite
0
--
Atg5:Atg12:DDX58:dsRNA:MAVS
--
e70
cso30:c:Complex
cso30:i:CC_Cytoplasm
--
csml-variable:Double
m70
0
infinite
0
--
--
e8
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell_WithoutCellWall_
--
--
--
csml-variable:Double
m8
0
infinite
0
--
--
e9
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytoplasm
--
--
--
csml-variable:Double
m9
0
infinite
0
--
p1
p1
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1
m3965*m119368*0.1
nodelay
--
0
PMID: 18280611,12524386 As for RNA recognition, TLR3 and TLR7/8 detect double-stranded RNA (ds-RNA) and single-stranded RNA (ss-RNA), respectively
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c27 : 1
stoichiometry:c28 : 1
stoichiometry:c29 : 1
m21*m28*0.1
nodelay
--
0
PMID: 18280611 It is quite interesting to presume that these bacterial proteins such as SmtB and MarR might interact with DAI (DLM-1/ZBP1) or ADARs through the Zbeta domain.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c30 : 1
stoichiometry:c31 : 1
stoichiometry:c32 : 1
m26*m30*0.1
nodelay
--
0
PMID: 18280611 It is quite interesting to presume that these bacterial proteins such as SmtB and MarR might interact with DAI (DLM-1/ZBP1) or ADARs through the Zbeta domain.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c33 : 1
stoichiometry:c34 : 1
stoichiometry:c35 : 1
m28*m30*0.1
nodelay
--
0
PMID: 18280611 It is quite interesting to presume that these bacterial proteins such as SmtB and MarR might interact with DAI (DLM-1/ZBP1) or ADARs through the Zbeta domain.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c36 : 1
stoichiometry:c37 : 1
stoichiometry:c38 : 1
m30*m15*0.1
nodelay
--
0
PMID: 18280611 ADARs bind to ds-RNA through its ds-RNA-binding domains to deaminate adenosine (A) to inosine (I) for RNA editing.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c39 : 1
stoichiometry:c40 : 1
stoichiometry:c41 : 1
m15*m76904*0.1
nodelay
--
0
PMID: 18280611 Figure1
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c42 : 1
stoichiometry:c43 : 1
stoichiometry:c44 : 1
m35*m41844*0.1
nodelay
--
0
PMID: 18280611 Figure1
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c45 : 1
m1639*0.1
nodelay
--
0
PMID: 18280611,10564822 Further study revealed that DLM-1 is upregulated not only in tumor stromal cells but also in macrophages upon stimulation with type II IFN (IFN-gamma).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c48 : 1
m38*0.1
nodelay
--
0
PMID: 18280611,17618271 This gene can also be induced by treatment with type I IFNs (IFN-alpha/beta)
p17
p18
cso30:i:ME_GeneExpression
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c50 : 1
m1636*0.1
nodelay
--
0
PMID: 18280611,17618271 This gene can also be induced by treatment with type I IFNs (IFN-alpha/beta)
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c52 : 1
m44*0.1
nodelay
--
0
PMID: 18280611,16413926,10564822 DAI (DLM-1/ZBP1) mRNA expression is also regulated by signaling triggered by PAMPs such as B-form DNA (B-DNA), IFN-stimulatory DNA (ISD) and lipopolysaccharides (LPS)
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1
m19940*m12*0.1
nodelay
--
0
PMID: 18280611,12524386 As for RNA recognition, TLR3 and TLR7/8 detect double-stranded RNA (ds-RNA) and single-stranded RNA (ss-RNA), respectively
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c53 : 1
stoichiometry:c54 : 1
m43*0.1
nodelay
--
0
PMID: 18280611,16413926,10564822 DAI (DLM-1/ZBP1) mRNA expression is also regulated by signaling triggered by PAMPs such as B-form DNA (B-DNA), IFN-stimulatory DNA (ISD) and lipopolysaccharides (LPS)
p19
p21
cso30:i:ME_GeneExpression
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c56 : 1
m157177*0.1
nodelay
--
0
PMID: 18280611,16413926,10564822 DAI (DLM-1/ZBP1) mRNA expression is also regulated by signaling triggered by PAMPs such as B-form DNA (B-DNA), IFN-stimulatory DNA (ISD) and lipopolysaccharides (LPS)
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c57 : 1
stoichiometry:c58 : 1
m10*0.1
nodelay
--
0
PMID: 18280611,12359878,3295042,16413926 Type I IFN activation can be evoked by intracellular infection by several bacteria, including L. monocytogenes,S. flexneri, enterophathogenic E. coli and L. pneumophila
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c60 : 1
m39*0.1
nodelay
--
0
PMID: 18280611,12359878,3295042,16413926 Type I IFN activation can be evoked by intracellular infection by several bacteria, including L. monocytogenes,S. flexneri, enterophathogenic E. coli and L. pneumophila
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c62 : 1
m40*0.1
nodelay
--
0
PMID: 18280611,12359878,3295042,16413926 Type I IFN activation can be evoked by intracellular infection by several bacteria, including L. monocytogenes,S. flexneri, enterophathogenic E. coli and L. pneumophila
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c63 : 1
stoichiometry:c64 : 1
m41*0.1
nodelay
--
0
PMID: 18280611,12359878,3295042,16413926 Type I IFN activation can be evoked by intracellular infection by several bacteria, including L. monocytogenes,S. flexneri, enterophathogenic E. coli and L. pneumophila
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c66 : 1
stoichiometry:c67 : 1
m15*m45*0.1
nodelay
--
0
PMID: 18280611 E3L also contains a double-stranded RNA binding domain at the C-terminus.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1
stoichiometry:c69 : 1
stoichiometry:c70 : 1
m44*m21*0.1
nodelay
--
0
PMID: 18280611
p28
p28
cso30:i:ME_Binding
cso30:i:CC_Cytoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c71 : 1
stoichiometry:c72 : 1
stoichiometry:c73 : 1
stoichiometry:c74 : 1
m3902*m977*m47*0.1
nodelay
--
0
PMID: 18280611,16286919 IRF-3 is activated by B-DNA through the TBK1- and IKKi-dependent signaling pathway PMID: 18280611 Figue 2 PMID: 18280611,17618271 Moreover, DAI (DLM-1/ZBP1) associates with both TBK1 and IRF-3 in a ligand-dependent manner
p29
p29
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c75 : 1
stoichiometry:c76 : 1
stoichiometry:c77 : 1
stoichiometry:c78 : 1
m48*0.1
nodelay
--
0
PMID: 18280611 Figue 2
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1
m19823*m12*0.1
nodelay
--
0
PMID: 18280611,12524386 As for RNA recognition, TLR3 and TLR7/8 detect double-stranded RNA (ds-RNA) and single-stranded RNA (ss-RNA), respectively
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c81 : 1
stoichiometry:c82 : 1
m316590*0.1
nodelay
--
0
PMID: 18280611 Figue 2
p31
p31
cso30:i:ME_Dimerization
cso30:i:CC_Cytoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c80 : 1
m19324*0.1
nodelay
--
0
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c84 : 1
m49*0.1
nodelay
--
0
PMID: 18280611 Figue 2
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c85 : 1
stoichiometry:c86 : 1
m49*0.1
nodelay
--
0
PMID: 18280611 Figue 2
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c88 : 1
stoichiometry:c89 : 1
m18*m68199*0.1
nodelay
--
0
PMID: 18280611 Figure 1
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c90 : 1
stoichiometry:c91 : 1
stoichiometry:c92 : 1
m17*m1572*0.1
nodelay
--
0
PMID: 18280611 Figue 1
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c94 : 1
stoichiometry:c95 : 1
m1572*m14*0.1
nodelay
--
0
PMID: 18280611 Figue 1
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c96 : 1
stoichiometry:c97 : 1
stoichiometry:c98 : 1
m1572*m13*0.1
nodelay
--
0
PMID: 18280611 Figue 1
p35
p38
cso30:i:ME_Binding
cso30:i:CC_Cytoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c104 : 1
stoichiometry:c105 : 1
m19314*m18998*0.1
nodelay
--
0
PMID: 18280611 Figue 1
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c103 : 1
stoichiometry:c110 : 1
stoichiometry:c106 : 1
m64*0.1
nodelay
--
0
PMID: 18280611,17709747 However, the Atg5?Atg12 conjugate, a key component of the autophagic machinery, interacts with the cytosolic RNA sensor RIG-I and its adaptor IFN-¦Â promoter stimulator 1 (IPS-1), resulting in the inhibition of the type I IFN production pathway
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1
m19828*m16*0.1
nodelay
--
0
PMID: 18280611 On the other hand, TLR9 recognizes specific DNA sequences that contain unmethylated CpG motifs, which are commonly found in the genomes of infectious bacteria and viruses.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c100 : 1
stoichiometry:c101 : 1
stoichiometry:c102 : 1
m34*m68199*0.1
nodelay
--
0
PMID: 18280611 Figure 1
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c107 : 1
stoichiometry:c108 : 1
stoichiometry:c109 : 1
m64*m69*0.1
nodelay
--
0
PMID: 18280611,17709747 However, the Atg5?Atg12 conjugate, a key component of the autophagic machinery, interacts with the cytosolic RNA sensor RIG-I and its adaptor IFN-¦Â promoter stimulator 1 (IPS-1), resulting in the inhibition of the type I IFN production pathway
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1
m41844*m15*0.1
nodelay
--
0
PMID: 18280611 Figure1
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
m20*0.1
nodelay
--
0
PMID: 18280611,15659550 PKZ is constitutively expressed at low levels and is highly induced in response to stimulation with poly(rI:rC), which mimics viral ds-RNA
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c21 : 1
stoichiometry:c22 : 1
stoichiometry:c23 : 1
m22*m24*0.1
nodelay
--
0
PMID: 18280611,11524677,10364558 Further study by Rich's group provided a structural basis of the Zalpha domain of DLM-1 or ADAR1 to interact with characteristic features of the left-handed helical Z-DNA backbone
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c18 : 1
stoichiometry:c19 : 1
stoichiometry:c20 : 1
m22*m21*0.1
nodelay
--
0
PMID: 18280611,11524677,10364558 Further study by Rich's group provided a structural basis of the Zalpha domain of DLM-1 or ADAR1 to interact with characteristic features of the left-handed helical Z-DNA backbone
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c24 : 1
stoichiometry:c26 : 1
m26*m21*0.1
nodelay
--
0
PMID: 18280611 It is quite interesting to presume that these bacterial proteins such as SmtB and MarR might interact with DAI (DLM-1/ZBP1) or ADARs through the Zbeta domain.
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--