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PMID: 18280611,12524386
As for RNA recognition, TLR3 and TLR7/8 detect double-stranded RNA (ds-RNA) and single-stranded RNA (ss-RNA), respectively
PMID: 18280611,12524386
As for RNA recognition, TLR3 and TLR7/8 detect double-stranded RNA (ds-RNA) and single-stranded RNA (ss-RNA), respectively
PMID: 18280611,12524386
As for RNA recognition, TLR3 and TLR7/8 detect double-stranded RNA (ds-RNA) and single-stranded RNA (ss-RNA), respectively
PMID: 18280611
On the other hand, TLR9 recognizes specific DNA sequences that contain unmethylated CpG motifs, which are commonly found in the genomes of infectious bacteria and viruses.
PMID: 18280611
Figure1
indirect
PMID: 18280611,15659550
PKZ is constitutively expressed at low levels and is highly induced in response to stimulation with poly(rI:rC), which mimics viral ds-RNA
PMID: 18280611,11524677,10364558
Further study by Rich's group provided a structural basis of the Zalpha domain of DLM-1 or ADAR1 to interact with characteristic features of the left-handed helical Z-DNA backbone
PMID: 18280611,11524677,10364558
Further study by Rich's group provided a structural basis of the Zalpha domain of DLM-1 or ADAR1 to interact with characteristic features of the left-handed helical Z-DNA backbone
PMID: 18280611
It is quite interesting to presume that these bacterial proteins such as SmtB and MarR might interact with DAI (DLM-1/ZBP1) or ADARs through the Zbeta domain.
PMID: 18280611
It is quite interesting to presume that these bacterial proteins such as SmtB and MarR might interact with DAI (DLM-1/ZBP1) or ADARs through the Zbeta domain.
PMID: 18280611
It is quite interesting to presume that these bacterial proteins such as SmtB and MarR might interact with DAI (DLM-1/ZBP1) or ADARs through the Zbeta domain.
PMID: 18280611
It is quite interesting to presume that these bacterial proteins such as SmtB and MarR might interact with DAI (DLM-1/ZBP1) or ADARs through the Zbeta domain.
PMID: 18280611
ADARs bind to ds-RNA through its ds-RNA-binding domains to deaminate adenosine (A) to inosine (I) for RNA editing.
PMID: 18280611
Figure1
PMID: 18280611
Figure1
indirect
PMID: 18280611,10564822
Further study revealed that DLM-1 is upregulated not only in tumor stromal cells but also in macrophages upon stimulation with type II IFN (IFN-gamma).
indirect
PMID: 18280611,17618271
This gene can also be induced by treatment with type I IFNs (IFN-alpha/beta)
indirect
PMID: 18280611,17618271
This gene can also be induced by treatment with type I IFNs (IFN-alpha/beta)
PMID: 18280611,16413926,10564822
DAI (DLM-1/ZBP1) mRNA expression is also regulated by signaling triggered by PAMPs such as B-form DNA (B-DNA), IFN-stimulatory DNA (ISD) and lipopolysaccharides (LPS)
indirect
PMID: 18280611,16413926,10564822
DAI (DLM-1/ZBP1) mRNA expression is also regulated by signaling triggered by PAMPs such as B-form DNA (B-DNA), IFN-stimulatory DNA (ISD) and lipopolysaccharides (LPS)
indirect
PMID: 18280611,16413926,10564822
DAI (DLM-1/ZBP1) mRNA expression is also regulated by signaling triggered by PAMPs such as B-form DNA (B-DNA), IFN-stimulatory DNA (ISD) and lipopolysaccharides (LPS)
indirect
PMID: 18280611,12359878,3295042,16413926
Type I IFN activation can be evoked by intracellular infection by several bacteria, including L. monocytogenes,S. flexneri, enterophathogenic E. coli and L. pneumophila
indirect
PMID: 18280611,12359878,3295042,16413926
Type I IFN activation can be evoked by intracellular infection by several bacteria, including L. monocytogenes,S. flexneri, enterophathogenic E. coli and L. pneumophila
indirect
PMID: 18280611,12359878,3295042,16413926
Type I IFN activation can be evoked by intracellular infection by several bacteria, including L. monocytogenes,S. flexneri, enterophathogenic E. coli and L. pneumophila
indirect
PMID: 18280611,12359878,3295042,16413926
Type I IFN activation can be evoked by intracellular infection by several bacteria, including L. monocytogenes,S. flexneri, enterophathogenic E. coli and L. pneumophila
PMID: 18280611
E3L also contains a double-stranded RNA binding domain at the C-terminus.
PMID: 18280611
PMID: 18280611,16286919
IRF-3 is activated by B-DNA through the TBK1- and IKKi-dependent signaling pathway
PMID: 18280611
Figue 2
PMID: 18280611,17618271
Moreover, DAI (DLM-1/ZBP1) associates with both TBK1 and IRF-3 in a ligand-dependent manner
PMID: 18280611
Figue 2
PMID: 18280611
Figue 2
indirect
PMID: 18280611
Figue 2
indirect
PMID: 18280611
Figue 2
PMID: 18280611
Figure 1
PMID: 18280611
Figue 1
PMID: 18280611
Figue 1
PMID: 18280611
Figue 1
PMID: 18280611
Figue 1
indirect
PMID: 18280611,17709747
However, the Atg5–Atg12 conjugate, a key component of the autophagic machinery, interacts with the cytosolic RNA sensor RIG-I and its adaptor IFN-β promoter stimulator 1 (IPS-1), resulting in the inhibition of the type I IFN production pathway
PMID: 18280611
Figure 1
PMID: 18280611,17709747
However, the Atg5–Atg12 conjugate, a key component of the autophagic machinery, interacts with the cytosolic RNA sensor RIG-I and its adaptor IFN-β promoter stimulator 1 (IPS-1), resulting in the inhibition of the type I IFN production pathway