Entity
IKK-alpha
--
MO000000210
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m181
10
infinite
0
InterPro | IPR000719 |
TRANSPATH | MO000000210 |
--
IRF-3
--
MO000007694
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m977
10
infinite
0
InterPro | IPR008984 |
TRANSPATH | MO000007694 |
--
IRF-7{p}
--
MO000007702
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m980
10
infinite
0
TRANSPATH | MO000007702 |
--
IKK-i
--
MO000016608
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m1599
10
infinite
0
InterPro | IPR000719 |
TRANSPATH | MO000016608 |
--
FADD
--
MO000016899
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m1814
10
infinite
0
InterPro | IPR001875 |
TRANSPATH | MO000016899 |
--
Caspase-10
--
MO000016906
cso30:c:Protein
cso30:i:CC_CellComponent
--
--
csml-variable:Double
m1821
10
infinite
0
TRANSPATH | MO000016906 |
--
dsRNA
--
MO000022224
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m119368
10
infinite
0
TRANSPATH | MO000022224 |
--
IRAK-4
--
MO000039077
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m17258
10
infinite
0
TRANSPATH | MO000039077 |
--
dsRNA:TLR3
--
MO000041446
cso30:c:Protein
cso30:i:CC_CellComponent
--
--
csml-variable:Double
m19314
10
infinite
0
TRANSPATH | MO000041446 |
--
DDX58
--
MO000066987
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m41844
10
infinite
0
TRANSPATH | MO000066987 |
--
ATG5:ATG12
--
MO000070429
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m45270
10
infinite
0
TRANSPATH | MO000070429 |
--
MAVS
--
MO000094908
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m68199
10
infinite
0
TRANSPATH | MO000094908 |
--
--
e1
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane
--
--
--
csml-variable:Double
m1
0
infinite
0
--
--
e10
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytosol
--
--
--
csml-variable:Double
m10
0
infinite
0
--
ssRNA:DDX58{ub}:MAVS:TRAF3{ub}
--
e11
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m11
0
infinite
0
--
PolyI:C:IFIH1:MAVS:TRAF3{ub}
--
e12
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m12
0
infinite
0
--
DDX58:ATG5:ATG12
--
e13
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m13
0
infinite
0
--
MAVS:ATG5:ATG12
--
e14
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m14
0
infinite
0
--
ssRNA:DDX58{ub}
--
e16
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m16
0
infinite
0
--
ssRNA:DDX58{ub}:MAVS:TRAF3{ub}:TANK:NAP1:SINTBAD
--
e17
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m17
0
infinite
0
--
NAP1
--
e18
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m18
0
infinite
0
--
SINTBAD
--
e19
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m19
0
infinite
0
--
--
e2
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m2
0
infinite
0
--
PolyI:C:IFIH1:MAVS:TRAF3{ub}:TANK:NAP1:SINTBAD
--
e20
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m20
0
infinite
0
--
ssRNA:DDX58{ub}:MAVS:TRAF3{ub}:TANK:NAP1:SINTBAD:TBK1:IKK-i
--
e21
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m21
0
infinite
0
--
degradants
--
e22
cso30:c:EntityBiological
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m22
0
infinite
0
--
PolyI:C:IFIH1:MAVS:TRAF3{ub}:TANK:NAP1:SINTBAD:TBK1:IKK-i
--
e23
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m23
0
infinite
0
--
IRF-3{p}
--
e24
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m24
10
infinite
0
InterPro | IPR008984 |
TRANSPATH | MO000007694 |
--
IRF-7
--
e25
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m25
10
infinite
0
TRANSPATH | MO000007702 |
--
IRF-3{p}:IRF-3{p}
--
e26
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m26
0
infinite
0
--
IRF-7{p}:IRF-7{p}
--
e27
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m27
0
infinite
0
--
IRF-3{p}:IRF-7{p}
--
e28
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m28
0
infinite
0
--
IRF-3{p}:IRF-7{p}
--
e29
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m29
0
infinite
0
--
--
e3
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
--
csml-variable:Double
m3
0
infinite
0
--
IRF-7{p}:IRF-7{p}
--
e30
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m30
0
infinite
0
--
IRF-3{p}:IRF-3{p}
--
e31
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m31
0
infinite
0
--
ISREs
--
e32
cso30:c:Dna
cso30:i:CC_Cytosol
--
csml-variable:Double
m32
0
infinite
0
--
IRF-7{p}:IRF-7{p}:ISRE
--
e33
cso30:c:Complex
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m33
0
infinite
0
--
IRF-3{p}:IRF-7{p}:ISRE
--
e34
cso30:c:Complex
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m34
0
infinite
0
--
IRF-3{p}:IRF-3{p}:ISRE
--
e35
cso30:c:Complex
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m35
0
infinite
0
--
Type I IFNs
--
e36
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m36
0
infinite
0
--
IFN inducible genes
--
e37
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m37
0
infinite
0
--
FADD:Caspase-8
--
e38
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m38
0
infinite
0
--
FADD:Caspase-10
--
e39
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m39
0
infinite
0
--
--
e4
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m4
0
infinite
0
--
FADD:MAVS
--
e40
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m40
0
infinite
0
--
IFNbeta receptor
--
e42
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m43
0
infinite
0
--
IFNbeta:IFNbeta receptor
--
e43
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m44
0
infinite
0
--
--
e46
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Endosome
--
--
--
csml-variable:Double
m47
0
infinite
0
--
--
e47
cso30:c:EntityBiologicalCompartment
cso30:i:CC_EndosomeLumen
--
--
--
csml-variable:Double
m48
0
infinite
0
--
--
e48
cso30:c:EntityBiologicalCompartment
cso30:i:CC_EndosomeMembrane
--
--
--
csml-variable:Double
m49
0
infinite
0
--
ssRNA
--
e49
cso30:c:Rna
cso30:i:CC_Cytosol
--
csml-variable:Double
m63
0
infinite
0
--
csml-variable:Double
m5
0
infinite
0
--
--
e50
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelopeLumen
--
--
--
csml-variable:Double
m50
0
infinite
0
--
--
e51
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearPore
--
--
--
csml-variable:Double
m51
0
infinite
0
--
--
e52
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearInnerMembrane
--
--
--
csml-variable:Double
m52
0
infinite
0
--
--
e53
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearLumen
--
--
--
csml-variable:Double
m53
0
infinite
0
--
--
e54
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearOuterMembrane
--
--
--
csml-variable:Double
m54
0
infinite
0
--
--
e55
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleus
--
--
--
csml-variable:Double
m55
0
infinite
0
--
--
e56
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleoplasm
--
--
--
csml-variable:Double
m56
0
infinite
0
--
--
e57
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearBody
--
--
--
csml-variable:Double
m57
0
infinite
0
--
--
e58
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleolus
--
--
--
csml-variable:Double
m58
0
infinite
0
--
--
e59
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelope
--
--
--
csml-variable:Double
m59
0
infinite
0
--
DDX58:LGP2
--
e6
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m6
0
infinite
0
--
--
e60
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Chromatin
--
--
--
csml-variable:Double
m60
0
infinite
0
--
--
e61
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearChromosome
--
--
--
csml-variable:Double
m61
0
infinite
0
--
--
e62
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearCentromere
--
--
--
csml-variable:Double
m62
0
infinite
0
--
TLR7:ssRNA
--
e63
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m64
0
infinite
0
--
TLR8:ssRNA
--
e64
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m65
0
infinite
0
--
CpG DNA
--
e65
cso30:c:Dna
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m66
0
infinite
0
--
TLR9:CpGDNA
--
e66
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m67
0
infinite
0
--
CpGDNA:TLR9:MyD88:IRAK:IRAK-4:IKK-alpha:IRF-7
--
e67
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m68
0
infinite
0
--
CpGDNA:TLR9:MyD88:IRAK:IRAK-4:IKK-alpha:IRF-7{p}
--
e68
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m69
0
infinite
0
--
ssRNA:TLR7:MyD88:IRAK:IRAK-4:IKK-alpha:IRF-7
--
e69
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m70
0
infinite
0
--
--
e7
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell
--
--
--
csml-variable:Double
m7
0
infinite
0
--
ssRNA:TLR7:MyD88:IRAK:IRAK-4:IKK-alpha:IRF-7{p}
--
e70
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m71
0
infinite
0
--
RLHs
--
e72
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m73
0
infinite
0
--
dsRNA:RLHs
--
e73
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m74
0
infinite
0
--
ssRNA
--
e75
cso30:c:Rna
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m76
0
infinite
0
--
ssRNA:DDX58
--
e76
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m77
0
infinite
0
--
ssRNA:DDX58{ub}:MAVS
--
e77
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m78
0
infinite
0
--
PolyI:C:IFIH1
--
e78
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m79
0
infinite
0
--
PolyI:C:IFIH1:MAVS
--
e79
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m80
0
infinite
0
--
--
e8
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell_WithoutCellWall_
--
--
--
csml-variable:Double
m8
0
infinite
0
--
TRAF3{ub}
--
e80
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m81
0
infinite
0
--
DUBA
--
e81
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m82
0
infinite
0
--
--
e9
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytoplasm
--
--
--
csml-variable:Double
m9
0
infinite
0
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1
m41844*m5*0.1
nodelay
--
0
PMID: 18272355 LGP2 also contains an RD, and this RD was found to interact with the RD of RIG-I and suppress its self-association.
p10
p10
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1
stoichiometry:c33 : 1
stoichiometry:c34 : 1
stoichiometry:c35 : 1
m17*m3902*m1599*0.1
nodelay
--
0
PMID: 18272355 TRAF3 recruits and activates two IKK-related kinases, designated TANK-binding kinase 1 (TBK1) and inducible I¦ÊB kinase (IKK-i; also known as IKKvar epsilon), which phosphorylate IRF-3 and IRF-7
p10
p11
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c36 : 1
stoichiometry:c37 : 1
stoichiometry:c22 : 1
stoichiometry:c39 : 1
m1599*m3902*m20*0.1
nodelay
--
0
PMID: 18272355 TRAF3 recruits and activates two IKK-related kinases, designated TANK-binding kinase 1 (TBK1) and inducible I¦ÊB kinase (IKK-i; also known as IKKvar epsilon), which phosphorylate IRF-3 and IRF-7
p12
p12
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1
stoichiometry:c42 : 1
m21*m977*0.1
nodelay
--
0
PMID: 18272355 TRAF3 recruits and activates two IKK-related kinases, designated TANK-binding kinase 1 (TBK1) and inducible I¦ÊB kinase (IKK-i; also known as IKKvar epsilon), which phosphorylate IRF-3 and IRF-7
p12
p13
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c44 : 1
stoichiometry:c45 : 1
m977*m23*0.1
nodelay
--
0
PMID: 18272355 TRAF3 recruits and activates two IKK-related kinases, designated TANK-binding kinase 1 (TBK1) and inducible I¦ÊB kinase (IKK-i; also known as IKKvar epsilon), which phosphorylate IRF-3 and IRF-7
p12
p14
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c47 : 1
stoichiometry:c48 : 1
m21*m25*0.1
nodelay
--
0
PMID: 18272355 TRAF3 recruits and activates two IKK-related kinases, designated TANK-binding kinase 1 (TBK1) and inducible I¦ÊB kinase (IKK-i; also known as IKKvar epsilon), which phosphorylate IRF-3 and IRF-7
p12
p15
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c50 : 1
stoichiometry:c51 : 1
m23*m25*0.1
nodelay
--
0
PMID: 18272355 TRAF3 recruits and activates two IKK-related kinases, designated TANK-binding kinase 1 (TBK1) and inducible I¦ÊB kinase (IKK-i; also known as IKKvar epsilon), which phosphorylate IRF-3 and IRF-7
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c53 : 1
m24*0.1
nodelay
--
0
PMID: 18272355,15800576 Phosphorylation of IRF-3 and IRF-7 by these kinases induces the formation of homodimers and/or heterodimers , which translocate into the nucleus and bind to IFN-stimulated response elements (ISREs), thereby resulting in the expression of type I IFN genes and a set of IFN-inducible genes.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c55 : 1
m980*0.1
nodelay
--
0
PMID: 18272355,15800576 Phosphorylation of IRF-3 and IRF-7 by these kinases induces the formation of homodimers and/or heterodimers , which translocate into the nucleus and bind to IFN-stimulated response elements (ISREs), thereby resulting in the expression of type I IFN genes and a set of IFN-inducible genes.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c57 : 1
stoichiometry:c58 : 1
m24*m980*0.1
nodelay
--
0
PMID: 18272355,15800576 Phosphorylation of IRF-3 and IRF-7 by these kinases induces the formation of homodimers and/or heterodimers , which translocate into the nucleus and bind to IFN-stimulated response elements (ISREs), thereby resulting in the expression of type I IFN genes and a set of IFN-inducible genes.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c62 : 1
m28*0.1
nodelay
--
0
PMID: 18272355,15800576 Phosphorylation of IRF-3 and IRF-7 by these kinases induces the formation of homodimers and/or heterodimers , which translocate into the nucleus and bind to IFN-stimulated response elements (ISREs), thereby resulting in the expression of type I IFN genes and a set of IFN-inducible genes.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c5 : 1
stoichiometry:c157 : 1
stoichiometry:c151 : 1
m68199*m16*0.1
nodelay
--
0
PMID:18272355,16127453,16125763,16153868,16177806 RIG-I and MDA5 associate with an adaptor protein, IFN-¦Â promoter stimulator 1 (IPS-1; also known as MAVS, VISA or CARDIF), which also contains a CARD
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c63 : 1
m27*0.1
nodelay
--
0
PMID: 18272355,15800576 Phosphorylation of IRF-3 and IRF-7 by these kinases induces the formation of homodimers and/or heterodimers , which translocate into the nucleus and bind to IFN-stimulated response elements (ISREs), thereby resulting in the expression of type I IFN genes and a set of IFN-inducible genes.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c64 : 1
m26*0.1
nodelay
--
0
PMID: 18272355,15800576 Phosphorylation of IRF-3 and IRF-7 by these kinases induces the formation of homodimers and/or heterodimers , which translocate into the nucleus and bind to IFN-stimulated response elements (ISREs), thereby resulting in the expression of type I IFN genes and a set of IFN-inducible genes.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c66 : 1
stoichiometry:c71 : 1
m30*m32*0.1
nodelay
--
0
PMID: 18272355,15800576 Phosphorylation of IRF-3 and IRF-7 by these kinases induces the formation of homodimers and/or heterodimers , which translocate into the nucleus and bind to IFN-stimulated response elements (ISREs), thereby resulting in the expression of type I IFN genes and a set of IFN-inducible genes.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c68 : 1
stoichiometry:c72 : 1
m29*m32*0.1
nodelay
--
0
PMID: 18272355,15800576 Phosphorylation of IRF-3 and IRF-7 by these kinases induces the formation of homodimers and/or heterodimers , which translocate into the nucleus and bind to IFN-stimulated response elements (ISREs), thereby resulting in the expression of type I IFN genes and a set of IFN-inducible genes.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c70 : 1
stoichiometry:c73 : 1
m31*m32*0.1
nodelay
--
0
PMID: 18272355,15800576 Phosphorylation of IRF-3 and IRF-7 by these kinases induces the formation of homodimers and/or heterodimers , which translocate into the nucleus and bind to IFN-stimulated response elements (ISREs), thereby resulting in the expression of type I IFN genes and a set of IFN-inducible genes.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c75 : 1
m33*0.1
nodelay
--
0
PMID: 18272355,15800576 Phosphorylation of IRF-3 and IRF-7 by these kinases induces the formation of homodimers and/or heterodimers , which translocate into the nucleus and bind to IFN-stimulated response elements (ISREs), thereby resulting in the expression of type I IFN genes and a set of IFN-inducible genes.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c77 : 1
m33*0.1
nodelay
--
0
PMID: 18272355,15800576 Phosphorylation of IRF-3 and IRF-7 by these kinases induces the formation of homodimers and/or heterodimers , which translocate into the nucleus and bind to IFN-stimulated response elements (ISREs), thereby resulting in the expression of type I IFN genes and a set of IFN-inducible genes.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c78 : 1
stoichiometry:c79 : 1
m34*0.1
nodelay
--
0
PMID: 18272355,15800576 Phosphorylation of IRF-3 and IRF-7 by these kinases induces the formation of homodimers and/or heterodimers , which translocate into the nucleus and bind to IFN-stimulated response elements (ISREs), thereby resulting in the expression of type I IFN genes and a set of IFN-inducible genes.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c80 : 1
stoichiometry:c81 : 1
m34*0.1
nodelay
--
0
PMID: 18272355,15800576 Phosphorylation of IRF-3 and IRF-7 by these kinases induces the formation of homodimers and/or heterodimers , which translocate into the nucleus and bind to IFN-stimulated response elements (ISREs), thereby resulting in the expression of type I IFN genes and a set of IFN-inducible genes.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c83 : 1
m35*0.1
nodelay
--
0
PMID: 18272355,15800576 Phosphorylation of IRF-3 and IRF-7 by these kinases induces the formation of homodimers and/or heterodimers , which translocate into the nucleus and bind to IFN-stimulated response elements (ISREs), thereby resulting in the expression of type I IFN genes and a set of IFN-inducible genes.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c154 : 1
stoichiometry:c8 : 1
m68199*m79*0.1
nodelay
--
0
PMID:18272355,16127453,16125763,16153868,16177806 RIG-I and MDA5 associate with an adaptor protein, IFN-¦Â promoter stimulator 1 (IPS-1; also known as MAVS, VISA or CARDIF), which also contains a CARD
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c85 : 1
m35*0.1
nodelay
--
0
PMID: 18272355,15800576 Phosphorylation of IRF-3 and IRF-7 by these kinases induces the formation of homodimers and/or heterodimers , which translocate into the nucleus and bind to IFN-stimulated response elements (ISREs), thereby resulting in the expression of type I IFN genes and a set of IFN-inducible genes.
p31
p31
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c87 : 1
stoichiometry:c88 : 1
m1814*m1815*0.1
nodelay
--
0
PMID: 18272355,16585540 In addition, FAS-associated death domain-containing protein (FADD) interacts with caspase-8, caspase-10 and IPS-1, and the FADD-dependent pathway is responsible for the activation of NF-¦ÊB downstream of IPS-1
p31
p32
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c89 : 1
stoichiometry:c90 : 1
stoichiometry:c91 : 1
m1814*m1821*0.1
nodelay
--
0
PMID: 18272355,16585540 In addition, FAS-associated death domain-containing protein (FADD) interacts with caspase-8, caspase-10 and IPS-1, and the FADD-dependent pathway is responsible for the activation of NF-¦ÊB downstream of IPS-1
p31
p33
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c92 : 1
stoichiometry:c93 : 1
stoichiometry:c94 : 1
m1814*m68199*0.1
nodelay
--
0
PMID: 18272355,16585540 In addition, FAS-associated death domain-containing protein (FADD) interacts with caspase-8, caspase-10 and IPS-1, and the FADD-dependent pathway is responsible for the activation of NF-¦ÊB downstream of IPS-1
p34
p34
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c95 : 1
stoichiometry:c96 : 1
stoichiometry:c97 : 1
m40*m41*0.1
nodelay
--
0
PMID: 18272355,16585540 In addition, FAS-associated death domain-containing protein (FADD) interacts with caspase-8, caspase-10 and IPS-1, and the FADD-dependent pathway is responsible for the activation of NF-¦ÊB downstream of IPS-1
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c98 : 1
stoichiometry:c99 : 1
stoichiometry:c100 : 1
m1636*m43*0.1
nodelay
--
0
PMID: 18272355,17332413 However, IKK-i is also activated by IFN-¦Â to directly phosphorylate STAT1, thereby controlling a set of IFN-inducible genes such as the dsRNA-activated adenosine deaminase gene
p36
p36
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c101 : 1
stoichiometry:c102 : 1
stoichiometry:c103 : 1
m44*m1599*0.1
nodelay
--
0
PMID: 18272355,17332413 However, IKK-i is also activated by IFN-¦Â to directly phosphorylate STAT1, thereby controlling a set of IFN-inducible genes such as the dsRNA-activated adenosine deaminase gene
p37
p37
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c104 : 1
stoichiometry:c106 : 1
stoichiometry:c105 : 1
m1357*m45*0.1
nodelay
--
0
PMID: 18272355,17332413 However, IKK-i is also activated by IFN-¦Â to directly phosphorylate STAT1, thereby controlling a set of IFN-inducible genes such as the dsRNA-activated adenosine deaminase gene
p38
p38
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c107 : 1
stoichiometry:c108 : 1
stoichiometry:c109 : 1
m3965*m119368*0.1
nodelay
--
0
PMID: 18272355 TLR3 detects double-stranded (ds) RNA, while TLR7 and TLR8 recognize single-stranded (ss) RNA and TLR9 recognizes unmethylated DNA with CpG motifs.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c110 : 1
stoichiometry:c111 : 1
stoichiometry:c112 : 1
m63*m19940*0.1
nodelay
--
0
PMID: 18272355 TLR3 detects double-stranded (ds) RNA, while TLR7 and TLR8 recognize single-stranded (ss) RNA and TLR9 recognizes unmethylated DNA with CpG motifs.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1
m41844*m45270*0.1
nodelay
--
0
PMID: 18272335,17709747 Recently, IPS-1 and RIG-I were found to associate with Atg5?Atg12 conjugates, which are essential components for autophagy
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c113 : 1
stoichiometry:c114 : 1
stoichiometry:c115 : 1
m63*m19823*0.1
nodelay
--
0
PMID: 18272355 TLR3 detects double-stranded (ds) RNA, while TLR7 and TLR8 recognize single-stranded (ss) RNA and TLR9 recognizes unmethylated DNA with CpG motifs.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c116 : 1
stoichiometry:c117 : 1
stoichiometry:c118 : 1
m66*m19828*0.1
nodelay
--
0
PMID: 18272355 TLR3 detects double-stranded (ds) RNA, while TLR7 and TLR8 recognize single-stranded (ss) RNA and TLR9 recognizes unmethylated DNA with CpG motifs.
p42
p42
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c119 : 1
stoichiometry:c120 : 1
stoichiometry:c121 : 1
stoichiometry:c122 : 1
stoichiometry:c123 : 1
stoichiometry:c132 : 1
stoichiometry:c124 : 1
m1572*m184*m17258*m181*m67*m25*0.1
nodelay
--
0
PMID: 18272355,15492225,15361868 pDCs produce huge amounts of type I IFNs in response to virus infections, and TLR signaling is essential for type I IFN production by pDCs. TLR7 and TLR9 are highly expressed on pDCs, and stimulation with viral RNA and DNA induces the recruitment of a complex of MyD88, IRAK-1, IRAK-4, IKK-alpha and IRF-7 to the receptor, thereby leading to the phosphorylation and nuclear translocation of IRF-7 to activate the expression of IFN-inducible genes
p42
p43
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c125 : 1
stoichiometry:c126 : 1
stoichiometry:c127 : 1
stoichiometry:c128 : 1
stoichiometry:c129 : 1
stoichiometry:c131 : 1
stoichiometry:c130 : 1
m1572*m184*m17258*m181*m64*m25*0.1
nodelay
--
0
PMID: 18272355,15492225,15361868 pDCs produce huge amounts of type I IFNs in response to virus infections, and TLR signaling is essential for type I IFN production by pDCs. TLR7 and TLR9 are highly expressed on pDCs, and stimulation with viral RNA and DNA induces the recruitment of a complex of MyD88, IRAK-1, IRAK-4, IKK-alpha and IRF-7 to the receptor, thereby leading to the phosphorylation and nuclear translocation of IRF-7 to activate the expression of IFN-inducible genes
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c133 : 1
stoichiometry:c134 : 1
m68*0.1
nodelay
--
0
PMID: 18272355,15492225,15361868 TLR7 and TLR9 are highly expressed on pDCs, and stimulation with viral RNA and DNA induces the recruitment of a complex of MyD88, IRAK-1, IRAK-4, IKK-alpha and IRF-7 to the receptor, thereby leading to the phosphorylation and nuclear translocation of IRF-7 to activate the expression of IFN-inducible genes
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c135 : 1
stoichiometry:c136 : 1
m70*0.1
nodelay
--
0
PMID: 18272355,15492225,15361868 TLR7 and TLR9 are highly expressed on pDCs, and stimulation with viral RNA and DNA induces the recruitment of a complex of MyD88, IRAK-1, IRAK-4, IKK-alpha and IRF-7 to the receptor, thereby leading to the phosphorylation and nuclear translocation of IRF-7 to activate the expression of IFN-inducible genes
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c137 : 1
stoichiometry:c138 : 1
stoichiometry:c139 : 1
m71*0.1
nodelay
--
0
PMID: 18272355,15492225,15361868 TLR7 and TLR9 are highly expressed on pDCs, and stimulation with viral RNA and DNA induces the recruitment of a complex of MyD88, IRAK-1, IRAK-4, IKK-alpha and IRF-7 to the receptor, thereby leading to the phosphorylation and nuclear translocation of IRF-7 to activate the expression of IFN-inducible genes
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c140 : 1
stoichiometry:c141 : 1
stoichiometry:c142 : 1
m69*0.1
nodelay
--
0
PMID: 18272355,15492225,15361868 TLR7 and TLR9 are highly expressed on pDCs, and stimulation with viral RNA and DNA induces the recruitment of a complex of MyD88, IRAK-1, IRAK-4, IKK-alpha and IRF-7 to the receptor, thereby leading to the phosphorylation and nuclear translocation of IRF-7 to activate the expression of IFN-inducible genes
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c143 : 1
stoichiometry:c144 : 1
m72*0.1
nodelay
--
0
PMID: 18272355,15492225,15361868 TLR7 and TLR9 are highly expressed on pDCs, and stimulation with viral RNA and DNA induces the recruitment of a complex of MyD88, IRAK-1, IRAK-4, IKK-alpha and IRF-7 to the receptor, thereby leading to the phosphorylation and nuclear translocation of IRF-7 to activate the expression of IFN-inducible genes
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c146 : 1
stoichiometry:c165 : 1
stoichiometry:c147 : 1
m73*m119368*0.1
nodelay
--
0
PMID: 18272355 RLHs interact with dsRNAs through their helicase domain, and dsRNA stimulation induces their ATP catalytic activity.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1
m68199*m45270*0.1
nodelay
--
0
PMID: 18272335,17709747 Recently, IPS-1 and RIG-I were found to associate with Atg5?Atg12 conjugates, which are essential components for autophagy
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c148 : 1
stoichiometry:c149 : 1
stoichiometry:c150 : 1
m76*m41844*0.1
nodelay
--
0
PMID: 18272355,17038590,17038589 On the other hand, RIG-I, but not MDA5, recognizes 5¡ì-triphosphate ssRNA synthesized by T7 polymerase in vitro
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c18 : 1
stoichiometry:c27 : 1
stoichiometry:c153 : 1
m76904*m15*0.1
nodelay
--
0
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c38 : 1
stoichiometry:c156 : 1
m63891*m77*0.1
nodelay
--
0
PMID: 18272355,17392790 First, the CARDs of RIG-I undergo Lys 63-linked ubiquitination by tripartite motif (TRIM) 25, a ubiquitin E3 ligase composed of a RING finger domain, a B box/coiled-coil domain and a SPRY domain
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c158 : 1
stoichiometry:c159 : 1
m80707*m77*0.1
nodelay
--
0
PMID: 18272355,17460044 On the other hand, RIG-I also undergoes ubiquitination by the ubiquitin ligase RNF125, which leads to its proteasomal degradation
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c160 : 1
stoichiometry:c161 : 1
m16*0.1
nodelay
--
0
PMID: 18272355,17460044 On the other hand, RIG-I also undergoes ubiquitination by the ubiquitin ligase RNF125, which leads to its proteasomal degradation
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c162 : 1
stoichiometry:c164 : 1
stoichiometry:c163 : 1
m1872*0.1
nodelay
--
0
PMID:18272355,16306937,16306936 IPS-1 was found to associate with TNF-receptor-associated factor (TRAF) 3, an E3 ubiquitin ligase assembling lysine 63-linked polyubiquitin chains, through its C-terminal TRAF domain PMID: 18272355,17991829 Recently, a deubiquitinase named DUBA was shown to deubiquitinate TRAF3 and suppress RLH signaling
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c20 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1
stoichiometry:c21 : 1
stoichiometry:c26 : 1
m3897*m19*m18*m12*0.1
nodelay
--
0
PMID: 18272355 Subsequently, TRAF3 recruits TANK/NAP1/SINTBAD and TBK1/IKK-i, which phosphorylate IRF-3 and IRF-7. PMID: 18272355 TBK1 and IKK-i interact with TRAF family member-associated NF-¦ÊB activator (TANK), NAK-associated protein 1 (NAP1) and similar to NAP1 TBK1 adaptor (SINTBAD).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c152 : 1
stoichiometry:c17 : 1
stoichiometry:c6 : 1
m78*m81*0.1
nodelay
--
0
PMID:18272355,16306937,16306936 IPS-1 was found to associate with TNF-receptor-associated factor (TRAF) 3, an E3 ubiquitin ligase assembling lysine 63-linked polyubiquitin chains, through its C-terminal TRAF domain
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c155 : 1
stoichiometry:c19 : 1
stoichiometry:c9 : 1
m80*m81*0.1
nodelay
--
0
PMID:18272355,16306937,16306936 IPS-1 was found to associate with TNF-receptor-associated factor (TRAF) 3, an E3 ubiquitin ligase assembling lysine 63-linked polyubiquitin chains, through its C-terminal TRAF domain
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c29 : 1
stoichiometry:c30 : 1
stoichiometry:c16 : 1
stoichiometry:c31 : 1
m18*m3897*m19*m11*0.1
nodelay
--
0
PMID: 18272355 Subsequently, TRAF3 recruits TANK/NAP1/SINTBAD and TBK1/IKK-i, which phosphorylate IRF-3 and IRF-7. PMID: 18272355 TBK1 and IKK-i interact with TRAF family member-associated NF-¦ÊB activator (TANK), NAK-associated protein 1 (NAP1) and similar to NAP1 TBK1 adaptor (SINTBAD).
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--