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found to interact with the RD of RIG-I and suppress its self-association. PMID:18272355,16127453,16125763,16153868,16177806 RIG-I and MDA5 associate with an adaptor protein, IFN-β promoter stimulator 1 (IPS-1; also known as MAVS, VISA or CARDIF), which also contains a CARD PMID:18272355,16127453,16125763,16153868,16177806 RIG-I and MDA5 associate with an adaptor protein, IFN-β promoter stimulator 1 (IPS-1; also known as MAVS, VISA or CARDIF), which also contains a CARD PMID: 18272335,17709747 Recently, IPS-1 and RIG-I were found to associate with Atg5–Atg12 conjugates, which are essential components for autophagy PMID: 18272335,17709747 Recently, IPS-1 and RIG-I were found to associate with Atg5–Atg12 conjugates, which are essential components for autophagy PMID: 18272355 Subsequently, TRAF3 recruits TANK/NAP1/SINTBAD and TBK1/IKK-i, which phosphorylate IRF-3 and IRF-7. PMID: 18272355 TBK1 and IKK-i interact with TRAF family member-associated NF-κB activator (TANK), NAK-associated protein 1 (NAP1) and similar to NAP1 TBK1 adaptor (SINTBAD). PMID:18272355,16306937,16306936 IPS-1 was found to associate with TNF-receptor-associated factor (TRAF) 3, an E3 ubiquitin ligase assembling lysine 63-linked polyubiquitin chains, through its C-terminal TRAF domain PMID:18272355,16306937,16306936 IPS-1 was found to associate with TNF-receptor-associated factor (TRAF) 3, an E3 ubiquitin ligase assembling lysine 63-linked polyubiquitin chains, through its C-terminal TRAF domain PMID: 18272355 Subsequently, TRAF3 recruits TANK/NAP1/SINTBAD and TBK1/IKK-i, which phosphorylate IRF-3 and IRF-7. PMID: 18272355 TBK1 and IKK-i interact with TRAF family member-associated NF-κB activator (TANK), NAK-associated protein 1 (NAP1) and similar to NAP1 TBK1 adaptor (SINTBAD). PMID: 18272355 TRAF3 recruits and activates two IKK-related kinases, designated TANK-binding kinase 1 (TBK1) and inducible IκB kinase (IKK-i; also known as IKKvar epsilon), which phosphorylate IRF-3 and IRF-7 PMID: 18272355 TRAF3 recruits and activates two IKK-related kinases, designated TANK-binding kinase 1 (TBK1) and inducible IκB kinase (IKK-i; also known as IKKvar epsilon), which phosphorylate IRF-3 and IRF-7 indirect PMID: 18272355 TRAF3 recruits and activates two IKK-related kinases, designated TANK-binding kinase 1 (TBK1) and inducible IκB kinase (IKK-i; also known as IKKvar epsilon), which phosphorylate IRF-3 and IRF-7 indirect PMID: 18272355 TRAF3 recruits and activates two IKK-related kinases, designated TANK-binding kinase 1 (TBK1) and inducible IκB kinase (IKK-i; also known as IKKvar epsilon), which phosphorylate IRF-3 and IRF-7 indirect PMID: 18272355 TRAF3 recruits and activates two IKK-related kinases, designated TANK-binding kinase 1 (TBK1) and inducible IκB kinase (IKK-i; also known as IKKvar epsilon), which phosphorylate IRF-3 and IRF-7 indirect PMID: 18272355 TRAF3 recruits and activates two IKK-related kinases, designated TANK-binding kinase 1 (TBK1) and inducible IκB kinase (IKK-i; also known as IKKvar epsilon), which phosphorylate IRF-3 and IRF-7 PMID: 18272355,15800576 Phosphorylation of IRF-3 and IRF-7 by these kinases induces the formation of homodimers and/or heterodimers , which translocate into the nucleus and bind to IFN-stimulated response elements (ISREs), thereby resulting in the expression of type I IFN genes and a set of IFN-inducible genes. PMID: 18272355,15800576 Phosphorylation of IRF-3 and IRF-7 by these kinases induces the formation of homodimers and/or heterodimers , which translocate into the nucleus and bind to IFN-stimulated response elements (ISREs), thereby resulting in the expression of type I IFN genes and a set of IFN-inducible genes. PMID: 18272355,15800576 Phosphorylation of IRF-3 and IRF-7 by these kinases induces the formation of homodimers and/or heterodimers , which translocate into the nucleus and bind to IFN-stimulated response elements (ISREs), thereby resulting in the expression of type I IFN genes and a set of IFN-inducible genes. PMID: 18272355,15800576 Phosphorylation of IRF-3 and IRF-7 by these kinases induces the formation of homodimers and/or heterodimers , which translocate into the nucleus and bind to IFN-stimulated response elements (ISREs), thereby resulting in the expression of type I IFN genes and a set of IFN-inducible genes. PMID: 18272355,15800576 Phosphorylation of IRF-3 and IRF-7 by these kinases induces the formation of homodimers and/or heterodimers , which translocate into the nucleus and bind to IFN-stimulated response elements (ISREs), thereby resulting in the expression of type I IFN genes and a set of IFN-inducible genes. PMID: 18272355,15800576 Phosphorylation of IRF-3 and IRF-7 by these kinases induces the formation of homodimers and/or heterodimers , which translocate into the nucleus and bind to IFN-stimulated response elements (ISREs), thereby resulting in the expression of type I IFN genes and a set of IFN-inducible genes. PMID: 18272355,15800576 Phosphorylation of IRF-3 and IRF-7 by these kinases induces the formation of homodimers and/or heterodimers , which translocate into the nucleus and bind to IFN-stimulated response elements (ISREs), thereby resulting in the expression of type I IFN genes and a set of IFN-inducible genes. PMID: 18272355,15800576 Phosphorylation of IRF-3 and IRF-7 by these kinases induces the formation of homodimers and/or heterodimers , which translocate into the nucleus and bind to IFN-stimulated response elements (ISREs), thereby resulting in the expression of type I IFN genes and a set of IFN-inducible genes. PMID: 18272355,15800576 Phosphorylation of IRF-3 and IRF-7 by these kinases induces the formation of homodimers and/or heterodimers , which translocate into the nucleus and bind to IFN-stimulated response elements (ISREs), thereby resulting in the expression of type I IFN genes and a set of IFN-inducible genes. indirect PMID: 18272355,15800576 Phosphorylation of IRF-3 and IRF-7 by these kinases induces the formation of homodimers and/or heterodimers , which translocate into the nucleus and bind to IFN-stimulated response elements (ISREs), thereby resulting in the expression of type I IFN genes and a set of IFN-inducible genes. indirect PMID: 18272355,15800576 Phosphorylation of IRF-3 and IRF-7 by these kinases induces the formation of homodimers and/or heterodimers , which translocate into the nucleus and bind to IFN-stimulated response elements (ISREs), thereby resulting in the expression of type I IFN genes and a set of IFN-inducible genes. indirect PMID: 18272355,15800576 Phosphorylation of IRF-3 and IRF-7 by these kinases induces the formation of homodimers and/or heterodimers , which translocate into the nucleus and bind to IFN-stimulated response elements (ISREs), thereby resulting in the expression of type I IFN genes and a set of IFN-inducible genes. indirect PMID: 18272355,15800576 Phosphorylation of IRF-3 and IRF-7 by these kinases induces the formation of homodimers and/or heterodimers , which translocate into the nucleus and bind to IFN-stimulated response elements (ISREs), thereby resulting in the expression of type I IFN genes and a set of IFN-inducible genes. indirect PMID: 18272355,15800576 Phosphorylation of IRF-3 and IRF-7 by these kinases induces the formation of homodimers and/or heterodimers , which translocate into the nucleus and bind to IFN-stimulated response elements (ISREs), thereby resulting in the expression of type I IFN genes and a set of IFN-inducible genes. indirect PMID: 18272355,15800576 Phosphorylation of IRF-3 and IRF-7 by these kinases induces the formation of homodimers and/or heterodimers , which translocate into the nucleus and bind to IFN-stimulated response elements (ISREs), thereby resulting in the expression of type I IFN genes and a set of IFN-inducible genes. PMID: 18272355,16585540 In addition, FAS-associated death domain-containing protein (FADD) interacts with caspase-8, caspase-10 and IPS-1, and the FADD-dependent pathway is responsible for the activation of NF-κB downstream of IPS-1 PMID: 18272355,16585540 In addition, FAS-associated death domain-containing protein (FADD) interacts with caspase-8, caspase-10 and IPS-1, and the FADD-dependent pathway is responsible for the activation of NF-κB downstream of IPS-1 PMID: 18272355,16585540 In addition, FAS-associated death domain-containing protein (FADD) interacts with caspase-8, caspase-10 and IPS-1, and the FADD-dependent pathway is responsible for the activation of NF-κB downstream of IPS-1 indirect PMID: 18272355,16585540 In addition, FAS-associated death domain-containing protein (FADD) interacts with caspase-8, caspase-10 and IPS-1, and the FADD-dependent pathway is responsible for the activation of NF-κB downstream of IPS-1 PMID: 18272355,17332413 However, IKK-i is also activated by IFN-β to directly phosphorylate STAT1, thereby controlling a set of IFN-inducible genes such as the dsRNA-activated adenosine deaminase gene indirect PMID: 18272355,17332413 However, IKK-i is also activated by IFN-β to directly phosphorylate STAT1, thereby controlling a set of IFN-inducible genes such as the dsRNA-activated adenosine deaminase gene indirect PMID: 18272355,17332413 However, IKK-i is also activated by IFN-β to directly phosphorylate STAT1, thereby controlling a set of IFN-inducible genes such as the dsRNA-activated adenosine deaminase gene PMID: 18272355 TLR3 detects double-stranded (ds) RNA, while TLR7 and TLR8 recognize single-stranded (ss) RNA and TLR9 recognizes unmethylated DNA with CpG motifs. PMID: 18272355 TLR3 detects double-stranded (ds) RNA, while TLR7 and TLR8 recognize single-stranded (ss) RNA and TLR9 recognizes unmethylated DNA with CpG motifs. PMID: 18272355 TLR3 detects double-stranded (ds) RNA, while TLR7 and TLR8 recognize single-stranded (ss) RNA and TLR9 recognizes unmethylated DNA with CpG motifs. PMID: 18272355 TLR3 detects double-stranded (ds) RNA, while TLR7 and TLR8 recognize single-stranded (ss) RNA and TLR9 recognizes unmethylated DNA with CpG motifs. PMID: 18272355,15492225,15361868 pDCs produce huge amounts of type I IFNs in response to virus infections, and TLR signaling is essential for type I IFN production by pDCs. TLR7 and TLR9 are highly expressed on pDCs, and stimulation with viral RNA and DNA induces the recruitment of a complex of MyD88, IRAK-1, IRAK-4, IKK-alpha and IRF-7 to the receptor, thereby leading to the phosphorylation and nuclear translocation of IRF-7 to activate the expression of IFN-inducible genes PMID: 18272355,15492225,15361868 pDCs produce huge amounts of type I IFNs in response to virus infections, and TLR signaling is essential for type I IFN production by pDCs. TLR7 and TLR9 are highly expressed on pDCs, and stimulation with viral RNA and DNA induces the recruitment of a complex of MyD88, IRAK-1, IRAK-4, IKK-alpha and IRF-7 to the receptor, thereby leading to the phosphorylation and nuclear translocation of IRF-7 to activate the expression of IFN-inducible genes PMID: 18272355,15492225,15361868 TLR7 and TLR9 are highly expressed on pDCs, and stimulation with viral RNA and DNA induces the recruitment of a complex of MyD88, IRAK-1, IRAK-4, IKK-alpha and IRF-7 to the receptor, thereby leading to the phosphorylation and nuclear translocation of IRF-7 to activate the expression of IFN-inducible genes PMID: 18272355,15492225,15361868 TLR7 and TLR9 are highly expressed on pDCs, and stimulation with viral RNA and DNA induces the recruitment of a complex of MyD88, IRAK-1, IRAK-4, IKK-alpha and IRF-7 to the receptor, thereby leading to the phosphorylation and nuclear translocation of IRF-7 to activate the expression of IFN-inducible genes PMID: 18272355,15492225,15361868 TLR7 and TLR9 are highly expressed on pDCs, and stimulation with viral RNA and DNA induces the recruitment of a complex of MyD88, IRAK-1, IRAK-4, IKK-alpha and IRF-7 to the receptor, thereby leading to the phosphorylation and nuclear translocation of IRF-7 to activate the expression of IFN-inducible genes PMID: 18272355,15492225,15361868 TLR7 and TLR9 are highly expressed on pDCs, and stimulation with viral RNA and DNA induces the recruitment of a complex of MyD88, IRAK-1, IRAK-4, IKK-alpha and IRF-7 to the receptor, thereby leading to the phosphorylation and nuclear translocation of IRF-7 to activate the expression of IFN-inducible genes indirect PMID: 18272355,15492225,15361868 TLR7 and TLR9 are highly expressed on pDCs, and stimulation with viral RNA and DNA induces the recruitment of a complex of MyD88, IRAK-1, IRAK-4, IKK-alpha and IRF-7 to the receptor, thereby leading to the phosphorylation and nuclear translocation of IRF-7 to activate the expression of IFN-inducible genes PMID: 18272355 RLHs interact with dsRNAs through their helicase domain, and dsRNA stimulation induces their ATP catalytic activity. PMID: 18272355,17038590,17038589 On the other hand, RIG-I, but not MDA5, recognizes 5′-triphosphate ssRNA synthesized by T7 polymerase in vitro indirect PMID: 18272355,17392790 First, the CARDs of RIG-I undergo Lys 63-linked ubiquitination by tripartite motif (TRIM) 25, a ubiquitin E3 ligase composed of a RING finger domain, a B box/coiled-coil domain and a SPRY domain indirect PMID: 18272355,17460044 On the other hand, RIG-I also undergoes ubiquitination by the ubiquitin ligase RNF125, which leads to its proteasomal degradation PMID: 18272355,17460044 On the other hand, RIG-I also undergoes ubiquitination by the ubiquitin ligase RNF125, which leads to its proteasomal degradation PMID:18272355,16306937,16306936 IPS-1 was found to associate with TNF-receptor-associated factor (TRAF) 3, an E3 ubiquitin ligase assembling lysine 63-linked polyubiquitin chains, through its C-terminal TRAF domain PMID: 18272355,17991829 Recently, a deubiquitinase named DUBA was shown to deubiquitinate TRAF3 and suppress RLH signaling