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PMID: 18262679,16473828
A recent study demonstrated that CD14 enhances dsRNA-mediated TLR3 activation by directly binding to poly(I:C) and mediating cellular uptake of poly(I:C)
PMID: 18262679, 16473828
A recent study demonstrated that CD14 enhances dsRNA-mediated TLR3 activation by directly binding to poly (I: C) and mediating cellular uptake of poly (I: C)
PMID: 182626279
The internalized poly(I:C) colocalizes with CD14 and TLR3.
PMID: 18262679,15644310
Since the extracellular domain of CD14 consists of LRRs,poly(I:C) might be transferred from CD14 to TLR3.
PMID: 182626279,11607032,16225392
TLR3 recognizes both in vitro-transcribed dsRNA and poly(I:C), suggesting that the RNA duplex and not 5′-triphosphate is critical for TLR3 activation
PMID: 182626279
Once TLR3 is dimerized by internalized dsRNA, it recruits the adaptor protein TICAM-1/TRIF
PMID: 182626279
Once TLR3 is dimerized by internalized dsRNA, it recruits the adaptor protein TICAM-1/TRIF
PMID: 18262679,12855817
TLR3 mediates signals via the adaptor protein TICAM-1/TRIF
PMID: 18262679
After the transient association of TLR3 with TICAM-1 through the TIR domains, TICAM-1 dissociates from TLR3 to form a speckle-like structure containing RIP1, TRAF3 and NAP1 where TICAM-1-mediated signaling is initiated.
PMID: 18262679,15502848
In addition, phosphorylation of two specific tyrosine residues (Tyr759 and Tyr858) in the TIR domain of TLR3 is essential for dsRNA-induced signaling
PMID:18262679
After the transient association of TLR3 with TICAM-1 through the TIR domains, TICAM-1 dissociates from TLR3 to form a speckle-like structure containing RIP1, TRAF3 and NAP1 where TICAM-1-mediated signaling is initiated.
PMID: 18262679
RIP1 associates with TICAM-1 via the PHIM domain in the C-terminal region and acts as an NF-κB activator and apoptosis mediator in TICAM-1-mediated signaling.
PMID: 18262679,15814722,15064760,14739303
Receptor-interacting protein 1 (RIP1), a kinase containing a death domain, associates with TICAM-1 via the RIP homotypic interaction motif (RHIM) domain in the C-terminal region and acts as an NF-κB inducer and apoptosis mediator in TICAM-1-mediated signaling
PMID:18262679
After the transient association of TLR3 with TICAM-1 through the TIR domains, TICAM-1 dissociates from TLR3 to form a speckle-like structure containing RIP1, TRAF3 and NAP1 where TICAM-1-mediated signaling is initiated.
PMID: 18262679,16306937,16306936
In addition, TRAF3 is involved in the TLR3-TICAM-1-mediated IRF-3 activation
PMID: 18262679,15611223
It is reported that NF-κB activating kinase (NAK)-associated protein 1 (NAP1) participates in the recruitment of IRF-3 kinases to the N-terminal region of TICAM-1
PMID: 18262679
TRAF3 and NAP1 participate in the recruitment and activation of the IRF-3 kinases TBK1 and IKKvar epsilon.
PMID: 18262679
TRAF6 directly binds to the N-terminal region of TICAM-1 through the TRAF domain
PMID: 18262679,14982987
Although TRAF6 is required for NF-κB activation in MEFs,poly(I:C)-induced NF-κB activation is not impaired in TRAF6-deficient macrophages
indirect
PMID: 18262679,14982987
Although TRAF6 is required for NF-κB activation in MEFs,poly(I:C)-induced NF-κB activation is not impaired in TRAF6-deficient macrophages
indirect
PMID: 18262679
RIP1 associates with TICAM-1 via the PHIM domain in the C-terminal region and acts as an NF-κB activator and apoptosis mediator in TICAM-1-mediated signaling.
PMID: 18262679,15814722,15064760,14739303
Receptor-interacting protein 1 (RIP1), a kinase containing a death domain, associates with TICAM-1 via the RIP homotypic interaction motif (RHIM) domain in the C-terminal region and acts as an NF-κB inducer and apoptosis mediator in TICAM-1-mediated signaling
PMID: 18262679
SARM and TICAM-1 have been shown to interact and SARM strongly suppresses NF-κB activation as well as IRF-3 activation by TICAM-1.
indirect
PMID: 18262679
RIP1 associates with TICAM-1 via the PHIM domain in the C-terminal region and acts as an NF-κB activator and apoptosis mediator in TICAM-1-mediated signaling.
PMID: 18262679,15814722,15064760,14739303
Receptor-interacting protein 1 (RIP1), a kinase containing a death domain, associates with TICAM-1 via the RIP homotypic interaction motif (RHIM) domain in the C-terminal region and acts as an NF-κB inducer and apoptosis mediator in TICAM-1-mediated signaling
PMID: 18262679
TRAF3 and NAP1 participate in the recruitment and activation of the IRF-3 kinases TBK1 and IKKvar epsilon.
PMID: 18262679,12702806,12692549
Once TICAM-1 is oligomerized, the serine-threonine kinases, TANK-binding kinase 1 (TBK-1; also called NAK or T2K) and IκB kinase-related kinase var epsilon (IKK-var epsilon; also called IKK-i), are activated and phosphorylate IRF-3
indirect
PMID: 18262679, 12702806, 12692549
Once TICAM-1 is oligomerized, the serine-threonine kinases, TANK-binding kinase 1 (TBK-1; also called NAK or T2K) and IκB kinase-related kinase var epsilon (IKK-var epsilon; also called IKK-i), are activated and phosphorylate IRF-3
PMID: 18262679
SARM and TICAM-1 have been shown to interact and SARM strongly suppresses NF-κB activation as well as IRF-3 activation by TICAM-1.
PMID: 18262679,11070172
Phosphoprylated IRF-3 translocates into the nucleus and induces IFN-beta gene transcription
PMID: 18262679
Phosphorylated IRF-3 translocates into the nucleus and together with NF-KappaB and AP-1 induces IFN-beta gene transcription.
PMID: 18262679
SARM and TICAM-1 have been shown to interact and SARM strongly suppresses NF-κB activation as well as IRF-3 activation by TICAM-1.
PMID: 18262679
Phosphorylated IRF-3 translocates into the nucleus and together with NF-κB and AP-1 induces IFN-beta gene transcription
indirect
indirect
indirect
PMID: 18262679
Phosphorylated IRF-3 translocates into the nucleus and together with NF-kappaB and AP-1 induces IFN-beta gene transcription
PMID: 18262679
Phosphatidylinositol 3-kinase (PI3-K) is recruited to these residues, and is required for full phosphorylation and activation of IRF-3.
PMID: 18262679,16858407
TLR3 also associates with c-Src tyrosine kinase on the endosome in response to dsRNA
indierct
Phosphatidylinositol 3-kinase (PI3-K) is recruited to these residues, and is required for full phosphorylation and activation of IRF-3.
indirect
PMID: 18262679
The Src kinase inhibitor markedly inhibits dsRNA-elicited phosphorylation of Akt, a downstream target of PI3-K.
indirect
PMID: 18262679,12855817
This activates the transcription factors interferon regulatory factor 3 (IRF-3), NF-KappaB, and AP-1 (a complex of activating transcription factor 2 (ATF2) and JUN), leading to the induction of type I IFN (especially IFN-beta), cytokine/chemokine production and dendritic cell (DC) maturation
PMID: 18262679
Phosphorylated IRF-3 translocates into the nucleus and together with NF-kappaB and AP-1 induces IFN-beta gene transcription
indirect
PMID: 18262679, 12855817
This activates the transcription factors interferon regulatory factor 3 (IRF-3), NF-KappaB, and AP-1 (a complex of activating transcription factor 2 (ATF2) and JUN), leading to the induction of type I IFN (especially IFN-beta), cytokine/chemokine production and dendritic cell (DC) maturation
indirect
PMID: 18262679, 12855817
This activates the transcription factors interferon regulatory factor 3 (IRF-3), NF-KappaB, and AP-1 (a complex of activating transcription factor 2 (ATF2) and JUN), leading to the induction of type I IFN (especially IFN-beta), cytokine/chemokine production and dendritic cell (DC) maturation
indirect
PMID: 18262679, 12855817
This activates the transcription factors interferon regulatory factor 3 (IRF-3), NF-KappaB, and AP-1 (a complex of activating transcription factor 2 (ATF2) and JUN), leading to the induction of type I IFN (especially IFN-beta), cytokine/chemokine production and dendritic cell (DC) maturation
PMID: 18262679,17038590,17038589
RIG-I and MDA5 recognize 5′-triphosphate-containing ssRNA/dsRNA and poly(I:C), respectively and induce IFN-alpha/beta production
PMID: 18262679,17038590,17038589
RIG-I and MDA5 recognize 5′-triphosphate-containing ssRNA/dsRNA and poly(I:C), respectively and induce IFN-alpha/beta production
PMID: 18262679,17038590,17038589
RIG-I and MDA5 recognize 5′-triphosphate-containing ssRNA/dsRNA and poly(I:C), respectively and induce IFN-alpha/beta production
indirect
indirect
PMID: 18262679, 17038590, 17038589
RIG-I and MDA5 recognize 5′-triphosphate-containing ssRNA/dsRNA and poly(I:C), respectively and induce IFN-alpha/beta production
indirect
indirect
PMID: 18262679, 17038590, 17038589
RIG-I and MDA5 recognize 5′-triphosphate-containing ssRNA/dsRNA and poly(I:C), respectively and induce IFN-alpha/beta production
indirect
indirect
PMID: 18262679, 17038590, 17038589
RIG-I and MDA5 recognize 5′-triphosphate-containing ssRNA/dsRNA and poly(I:C), respectively and induce IFN-alpha/beta production
indirect
indirect
PMID: 18262679, 17038590, 17038589
RIG-I and MDA5 recognize 5′-triphosphate-containing ssRNA/dsRNA and poly(I:C), respectively and induce IFN-alpha/beta production
indirect
indirect
PMID: 18262679, 17038590, 17038589
RIG-I and MDA5 recognize 5′-triphosphate-containing ssRNA/dsRNA and poly(I:C), respectively and induce IFN-alpha/beta production
indirect
indirect
PMID: 18262679, 17038590, 17038589
RIG-I and MDA5 recognize 5′-triphosphate-containing ssRNA/dsRNA and poly(I:C), respectively and induce IFN-alpha/beta production
indirect
PMID: 18262679, 12855817
This activates the transcription factors interferon regulatory factor 3 (IRF-3), NF-KappaB, and AP-1 (a complex of activating transcription factor 2 (ATF2) and JUN), leading to the induction of type I IFN (especially IFN-beta), cytokine/chemokine production and dendritic cell (DC) maturation
indirect
PMID: 18262679, 12855817
This activates the transcription factors interferon regulatory factor 3 (IRF-3), NF-KappaB, and AP-1 (a complex of activating transcription factor 2 (ATF2) and JUN), leading to the induction of type I IFN (especially IFN-beta), cytokine/chemokine production and dendritic cell (DC) maturation
indirect
PMID: 18262679, 12855817
This activates the transcription factors interferon regulatory factor 3 (IRF-3), NF-KappaB, and AP-1 (a complex of activating transcription factor 2 (ATF2) and JUN), leading to the induction of type I IFN (especially IFN-beta), cytokine/chemokine production and dendritic cell (DC) maturation