Entity
TNF-alpha
--
G010329
cso30:c:mRNA
cso30:i:CC_CellComponent
--
csml-variable:Double
m93309
10
infinite
0
TRANSFAC | G010329 |
--
IL-12 p40
--
G010657
cso30:c:mRNA
cso30:i:CC_CellComponent
--
csml-variable:Double
m93589
10
infinite
0
TRANSFAC | G010657 |
--
NF-kappaB
--
MO000000058
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m34
10
infinite
0
TRANSPATH | MO000000058 |
--
IRF-7{p}
--
MO000041457
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m19325
10
infinite
0
TRANSPATH | MO000041457 |
--
TLR9
--
MO000042012
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m19828
10
infinite
0
TRANSPATH | MO000042012 |
--
--
e1
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane
--
--
--
csml-variable:Double
m1
0
infinite
0
--
--
e10
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytosol
--
--
--
csml-variable:Double
m10
0
infinite
0
--
TLR9:CgG DNA:MyD88:IRAK1:IRAK4:TRAF6:IRF-7
--
e102
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m104
0
infinite
0
--
TLR9:CgG DNA:MyD88:IRAK1:IRAK4:TRAF6:IRF-7{p}
--
e103
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m105
0
infinite
0
--
Type I IFN
--
e104
cso30:c:mRNA
cso30:i:CC_NuclearBody
--
--
csml-variable:Double
m106
0
infinite
0
--
IFN inducible genes
--
e105
cso30:c:mRNA
cso30:i:CC_NuclearBody
--
--
csml-variable:Double
m107
0
infinite
0
--
TLR9:CpG DNA:MyD88:IRAK1:IRAK4
--
e106
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m108
0
infinite
0
--
TLR9:CgG DNA:MyD88:IRAK1{p}:IRAK4
--
e107
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m109
0
infinite
0
--
TLR9:CgG DNA:MyD88:IRAK1{p}:IRAK4:TRAF6
--
e108
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m110
0
infinite
0
--
csml-variable:Double
m111
0
infinite
0
--
--
e11
cso30:c:EntityBiologicalCompartment
cso30:i:CC_EndosomeMembrane
--
--
--
csml-variable:Double
m11
0
infinite
0
--
TLR9:Viral DNA
--
e110
cso30:c:Complex
cso30:i:CC_EndosomeLumen
--
--
csml-variable:Double
m112
0
infinite
0
--
Viral RNA
--
e111
cso30:c:Rna
cso30:i:CC_Cytosol
--
csml-variable:Double
m113
0
infinite
0
--
DDX58:Viral RNA
--
e112
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m114
0
infinite
0
--
IFIH1:Viral RNA
--
e113
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m115
0
infinite
0
--
Type I IFN
--
e114
cso30:c:mRNA
cso30:i:CC_NuclearBody
--
csml-variable:Double
m116
0
infinite
0
--
csml-variable:Double
m117
0
infinite
0
--
ZBP1:DNA
--
e116
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m118
0
infinite
0
--
csml-variable:Double
m12
0
infinite
0
--
microbial Lipoproteins
--
e14
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m14
0
infinite
0
--
micorbial lipoproteins:TLR2:TLR1
--
e15
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m15
0
infinite
0
--
LPS:TLR4
--
e16
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m16
0
infinite
0
--
micorbial lipoproteins:TLR2:TLR6
--
e17
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m17
0
infinite
0
--
ssRNA
--
e18
cso30:c:Rna
cso30:i:CC_Cytosol
--
csml-variable:Double
m18
0
infinite
0
--
TLR7:ssRNA
--
e19
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m19
0
infinite
0
--
--
e2
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m2
0
infinite
0
--
TLR8:ssRNA
--
e20
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m20
0
infinite
0
--
TLR9:CpGDNA
--
e21
cso30:c:Complex
cso30:i:CC_EndosomeLumen
--
csml-variable:Double
m21
0
infinite
0
--
csml-variable:Double
m22
0
infinite
0
--
TLR9:Bacterial DNA
--
e23
cso30:c:Complex
cso30:i:CC_EndosomeLumen
--
--
csml-variable:Double
m23
0
infinite
0
--
Hemozoin
--
e24
cso30:c:SmallMolecule
cso30:i:CC_EndosomeLumen
--
--
csml-variable:Double
m24
0
infinite
0
--
TLR9:hemozoin
--
e25
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m25
0
infinite
0
--
TLR9:CpG DNA:MyD88
--
e26
cso30:c:Complex
cso30:i:CC_EndosomeLumen
--
csml-variable:Double
m26
0
infinite
0
--
TLR9:CpG DNA:MyD88:IRAK1:IRAK4
--
e27
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m27
0
infinite
0
--
TLR9:CgG DNA:MyD88:IRAK1{p}:IRAK4
--
e28
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m28
0
infinite
0
--
TLR9:CgG DNA:MyD88:IRAK1{p}:IRAK4:TRAF6
--
e29
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m29
0
infinite
0
--
--
e3
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
--
csml-variable:Double
m3
0
infinite
0
--
NF-KappaB:IKappa-B
--
e32
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m32
0
infinite
0
--
NF-KappaB:IKappa-B{p}
--
e33
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m33
0
infinite
0
--
degradants
--
e35
cso30:c:EntityBiological
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m36
0
infinite
0
--
--
e4
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m4
0
infinite
0
--
TLR9:CpG DNA:MyD88:IRF-5
--
e40
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m41
0
infinite
0
--
--
e41
cso30:c:EntityBiologicalCompartment
cso30:i:CC_EndoplasmicReticulum_IntegralToMembrane_
--
--
--
csml-variable:Double
m42
0
infinite
0
--
--
e42
cso30:c:EntityBiologicalCompartment
cso30:i:CC_EndoplasmicReticulumLumen
--
--
--
csml-variable:Double
m43
0
infinite
0
--
--
e43
cso30:c:EntityBiologicalCompartment
cso30:i:CC_EndoplasmicReticulum
--
--
--
csml-variable:Double
m44
0
infinite
0
--
--
e44
cso30:c:EntityBiologicalCompartment
cso30:i:CC_EndoplasmicReticulum_ExtrinsicToInternalSideOfMembrane_
--
--
--
csml-variable:Double
m45
0
infinite
0
--
--
e45
cso30:c:EntityBiologicalCompartment
cso30:i:CC_EndoplasmicReticulum_Membrane_
--
--
--
csml-variable:Double
m46
0
infinite
0
--
--
e46
cso30:c:EntityBiologicalCompartment
cso30:i:CC_EndoplasmicReticulum_ExtrinsicToExternalSideOfMembrane_
--
--
--
csml-variable:Double
m47
0
infinite
0
--
Unc93B
--
e48
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m49
0
infinite
0
--
TLR9:CpGDNA:Unc93B
--
e49
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m63
0
infinite
0
--
--
e5
cso30:c:EntityBiologicalCompartment
cso30:i:CC_EndosomeLumen
--
--
--
csml-variable:Double
m5
0
infinite
0
--
--
e50
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelopeLumen
--
--
--
csml-variable:Double
m50
0
infinite
0
--
--
e51
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearPore
--
--
--
csml-variable:Double
m51
0
infinite
0
--
--
e52
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearInnerMembrane
--
--
--
csml-variable:Double
m52
0
infinite
0
--
--
e53
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearLumen
--
--
--
csml-variable:Double
m53
0
infinite
0
--
--
e54
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearOuterMembrane
--
--
--
csml-variable:Double
m54
0
infinite
0
--
--
e55
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleus
--
--
--
csml-variable:Double
m55
0
infinite
0
--
--
e56
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleoplasm
--
--
--
csml-variable:Double
m56
0
infinite
0
--
--
e57
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearBody
--
--
--
csml-variable:Double
m57
0
infinite
0
--
--
e58
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleolus
--
--
--
csml-variable:Double
m58
0
infinite
0
--
--
e59
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelope
--
--
--
csml-variable:Double
m59
0
infinite
0
--
--
e6
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Endosome
--
--
--
csml-variable:Double
m6
0
infinite
0
--
--
e60
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Chromatin
--
--
--
csml-variable:Double
m60
0
infinite
0
--
--
e61
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearChromosome
--
--
--
csml-variable:Double
m61
0
infinite
0
--
--
e62
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearCentromere
--
--
--
csml-variable:Double
m62
0
infinite
0
--
MHC Class II
--
e63
cso30:c:mRNA
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m64
0
infinite
0
--
MHC Class II molecules
--
e64
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m65
0
infinite
0
--
Co-stimulatory molecules
--
e65
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
csml-variable:Double
m66
0
infinite
0
--
Co-stimulatory molecules
--
e66
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
--
csml-variable:Double
m67
0
infinite
0
--
IL-15
--
e67
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
--
csml-variable:Double
m68
0
infinite
0
--
CD40L
--
e68
cso30:c:Protein
cso30:i:CC_Extracellular
--
csml-variable:Double
m70
0
infinite
0
--
--
e69
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m71
0
infinite
0
--
--
e7
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell
--
--
--
csml-variable:Double
m7
0
infinite
0
--
--
e70
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m72
0
infinite
0
--
--
e71
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
--
csml-variable:Double
m73
0
infinite
0
--
--
e72
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane
--
--
--
csml-variable:Double
m74
0
infinite
0
--
--
e73
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Chromatin
--
--
--
csml-variable:Double
m75
0
infinite
0
--
--
e74
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearCentromere
--
--
--
csml-variable:Double
m76
0
infinite
0
--
--
e75
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearChromosome
--
--
--
csml-variable:Double
m77
0
infinite
0
--
--
e76
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelope
--
--
--
csml-variable:Double
m78
0
infinite
0
--
--
e77
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearPore
--
--
--
csml-variable:Double
m79
0
infinite
0
--
--
e78
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearOuterMembrane
--
--
--
csml-variable:Double
m80
0
infinite
0
--
--
e79
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearInnerMembrane
--
--
--
csml-variable:Double
m81
0
infinite
0
--
--
e8
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell_WithoutCellWall_
--
--
--
csml-variable:Double
m8
0
infinite
0
--
--
e80
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearBody
--
--
--
csml-variable:Double
m82
0
infinite
0
--
--
e81
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearLumen
--
--
--
csml-variable:Double
m83
0
infinite
0
--
--
e82
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleus
--
--
--
csml-variable:Double
m84
0
infinite
0
--
--
e83
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleoplasm
--
--
--
csml-variable:Double
m85
0
infinite
0
--
--
e84
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleolus
--
--
--
csml-variable:Double
m86
0
infinite
0
--
--
e85
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelopeLumen
--
--
--
csml-variable:Double
m87
0
infinite
0
--
--
e87
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell_WithoutCellWall_
--
--
--
csml-variable:Double
m89
0
infinite
0
--
--
e88
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell
--
--
--
csml-variable:Double
m90
0
infinite
0
--
--
e89
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytosol
--
--
--
csml-variable:Double
m91
0
infinite
0
--
--
e9
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytoplasm
--
--
--
csml-variable:Double
m9
0
infinite
0
--
CD40:CD40L
--
e90
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m92
0
infinite
0
--
TLR9:CgG DNA:MyD88:IRAK1{p}:IRAK4:TRAF6:IRF-1
--
e91
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m93
0
infinite
0
--
--
e93
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Endosome
--
--
--
csml-variable:Double
m95
0
infinite
0
--
--
e94
cso30:c:EntityBiologicalCompartment
cso30:i:CC_EndosomeMembrane
--
--
--
csml-variable:Double
m96
0
infinite
0
--
--
e95
cso30:c:EntityBiologicalCompartment
cso30:i:CC_EndosomeLumen
--
--
--
csml-variable:Double
m97
0
infinite
0
--
TLR9:CpGDNA
--
e96
cso30:c:Complex
cso30:i:CC_EndosomeLumen
--
csml-variable:Double
m98
0
infinite
0
--
TLR9:CpG DNA:MyD88
--
e98
cso30:c:Complex
cso30:i:CC_EndosomeLumen
--
csml-variable:Double
m100
0
infinite
0
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1
m14*m3964*0.1
nodelay
--
0
PMID: 18262306,10549626,9851930,10201887 TLR2 (together with TLR1 or TLR6) and TLR4 are the receptors mainly involved in the recognition of bacteria-derived ligands, such as microbial lipoproteins and LPS, respectively
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c28 : 1
stoichiometry:c30 : 1
m1572*m21*0.1
nodelay
--
0
PMID: 18262306 MyD88, one of these adaptors containing a TIR domain and a death domain (DD), is known to be essential for initiating TLR9 signaling.
p11
p11
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1
stoichiometry:c33 : 1
stoichiometry:c34 : 1
m26*m184*m17258*0.1
nodelay
--
0
PMID: 18262306 MyD88 in turn interacts with interleukin-1 receptor-associated kinase-1 (IRAK-1) and IRAK-4 through its DD.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c36 : 1
m27*0.1
nodelay
--
0
PMID: 18262306,17485511 IRAK-4 and its kinase activity are shown to be essential for TLR9-mediated cytokine production PMID: 18262306 IRAK-1 is a known substrate of IRAK-4, and phosphorylated IRAK-1 upregulates its kinase activity, and subsequently recruits tumor necrosis factor associated factor 6 (TRAF6).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c38 : 1
stoichiometry:c39 : 1
m28*m183*0.1
nodelay
--
0
PMID: 18262306 IRAK-1 is a known substrate of IRAK-4, and phosphorylated IRAK-1 upregulates its kinase activity, and subsequently recruits tumor necrosis factor associated factor 6 (TRAF6).
p14
p14
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1
stoichiometry:c42 : 1
m29*m1573*0.1
nodelay
--
0
PMID: 18262306,11460167 Downstream of TRAF6, transforming growth factor-beta associated kinase 1 (TAK1) is activated to the phosphorylate IKappaB kinase (IKK) complex, which phosphorylates IKappaB to induce nuclear translocation of NF-KappaB
p15
p15
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c44 : 1
stoichiometry:c45 : 1
m30*m207*0.1
nodelay
--
0
PMID: 18262306, 11460167 Downstream of TRAF6, transforming growth factor-beta associated kinase 1 (TAK1) is activated to the phosphorylate IKappaB kinase (IKK) complex, which phosphorylates IKappaB to induce nuclear translocation of NF-KappaB
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c47 : 1
stoichiometry:c48 : 1
m31*m32*0.1
nodelay
--
0
PMID: 18262306, 11460167 Downstream of TRAF6, transforming growth factor-beta associated kinase 1 (TAK1) is activated to the phosphorylate IKappaB kinase (IKK) complex, which phosphorylates IKappaB to induce nuclear translocation of NF-KappaB
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c50 : 1
m37*0.1
nodelay
--
0
PMID: 18262306, 11460167 Downstream of TRAF6, transforming growth factor-beta associated kinase 1 (TAK1) is activated to the phosphorylate IKappaB kinase (IKK) complex, which phosphorylates I¦ÊB to induce nuclear translocation of NF-KappaB
p18
p18
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c52 : 1
stoichiometry:c57 : 1
stoichiometry:c53 : 1
m30*m69*m6443*0.1
nodelay
--
0
PMID: 18262306 Figure1 PMID: 18262306,16862162,16186825 A study of Ubc13-deificient mice revealed that UBC13 is prerequisite for the activation of mitogen-activated protein (MAP) kinases, but is dispensable for NF-KappaB activation, whereas TAK1 is required for both
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c54 : 1
stoichiometry:c55 : 1
m33*0.1
nodelay
--
0
PMID: 18262306 Figure1
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1
m155666*m3961*0.1
nodelay
--
0
PMID: 18262306,10549626,9851930,10201887 TLR2 (together with TLR1 or TLR6) and TLR4 are the receptors mainly involved in the recognition of bacteria-derived ligands, such as microbial lipoproteins and LPS, respectively
p20
p20
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c59 : 1
stoichiometry:c60 : 1
m35*m219*0.1
nodelay
--
0
PMID: 18262306 Figure 1
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c62 : 1
m38*0.1
nodelay
--
0
PMID: 18262306 Figure 1
p22
p22
cso30:i:ME_GeneExpression
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c63 : 1
stoichiometry:c64 : 1
m34*0.1
nodelay
--
0
PMID: 18262306 Transcription factors NF-KappaB and AP-1 are responsible for the transcription of proinflammatory cytokine genes, including TNF-alpha, IL-6 and IL-12. PMID: 18262306,12626561 Upon B or K-type CpG-DNA stimulation, cDCs and macrophages produce proinflammatory cytokines, such as TNF-alpha, IL-6 and IL-12, and upregulate surface expression of MHC class II and co-stimulatory molecules
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c66 : 1
m39*0.1
nodelay
--
0
PMID: 18262306 Transcription factors NF-KappaB and AP-1 are responsible for the transcription of proinflammatory cytokine genes, including TNF-alpha, IL-6 and IL-12. PMID: 18262306,12626561 Upon B or K-type CpG-DNA stimulation, cDCs and macrophages produce proinflammatory cytokines, such as TNF-alpha, IL-6 and IL-12, and upregulate surface expression of MHC class II and co-stimulatory molecules
p22
p24
cso30:i:ME_GeneExpression
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c68 : 1
m34*0.1
nodelay
--
0
PMID: 18262306 Transcription factors NF-KappaB and AP-1 are responsible for the transcription of proinflammatory cytokine genes, including TNF-alpha, IL-6 and IL-12. PMID: 18262306,12626561 Upon B or K-type CpG-DNA stimulation, cDCs and macrophages produce proinflammatory cytokines, such as TNF-alpha, IL-6 and IL-12, and upregulate surface expression of MHC class II and co-stimulatory molecules
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c70 : 1
m39*0.1
nodelay
--
0
PMID: 18262306 Transcription factors NF-KappaB and AP-1 are responsible for the transcription of proinflammatory cytokine genes, including TNF-alpha, IL-6 and IL-12. PMID: 18262306,12626561 Upon B or K-type CpG-DNA stimulation, cDCs and macrophages produce proinflammatory cytokines, such as TNF-alpha, IL-6 and IL-12, and upregulate surface expression of MHC class II and co-stimulatory molecules
p22
p26
cso30:i:ME_GeneExpression
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c71 : 1
stoichiometry:c72 : 1
m34*0.1
nodelay
--
0
PMID: 18262306 Transcription factors NF-KappaB and AP-1 are responsible for the transcription of proinflammatory cytokine genes, including TNF-alpha, IL-6 and IL-12. PMID: 18262306,12626561 Upon B or K-type CpG-DNA stimulation, cDCs and macrophages produce proinflammatory cytokines, such as TNF-alpha, IL-6 and IL-12, and upregulate surface expression of MHC class II and co-stimulatory molecules
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c74 : 1
m39*0.1
nodelay
--
0
PMID: 18262306 Transcription factors NF-KappaB and AP-1 are responsible for the transcription of proinflammatory cytokine genes, including TNF-alpha, IL-6 and IL-12. PMID: 18262306,12626561 Upon B or K-type CpG-DNA stimulation, cDCs and macrophages produce proinflammatory cytokines, such as TNF-alpha, IL-6 and IL-12, and upregulate surface expression of MHC class II and co-stimulatory molecules
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c75 : 1
stoichiometry:c76 : 1
stoichiometry:c77 : 1
m26*m979*0.1
nodelay
--
0
PMID: 18262306 IRF-5 interacts with MyD88 and TLR stimulation induces nuclear translocation of IRF-5 which regulates the production of several cytokines such as IL-6, IL-12, and TNF-alpha
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c78 : 1
stoichiometry:c79 : 1
stoichiometry:c80 : 1
m41*0.1
nodelay
--
0
PMID: 18262306 IRF-5 interacts with MyD88 and TLR stimulation induces nuclear translocation of IRF-5 which regulates the production of several cytokines such as IL-6, IL-12, and TNF-alpha
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1
m14*m13*0.1
nodelay
--
0
PMID: 18262306,10549626,9851930,10201887 TLR2 (together with TLR1 or TLR6) and TLR4 are the receptors mainly involved in the recognition of bacteria-derived ligands, such as microbial lipoproteins and LPS, respectively
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c81 : 1
stoichiometry:c82 : 1
m40*0.1
nodelay
--
0
PMID: 18262306 IRF-5 interacts with MyD88 and TLR stimulation induces nuclear translocation of IRF-5 which regulates the production of several cytokines such as IL-6, IL-12, and TNF-alpha
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c84 : 1
m40*0.1
nodelay
--
0
PMID: 18262306 IRF-5 interacts with MyD88 and TLR stimulation induces nuclear translocation of IRF-5 which regulates the production of several cytokines such as IL-6, IL-12, and TNF-alpha
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c85 : 1
stoichiometry:c86 : 1
m40*0.1
nodelay
--
0
PMID: 18262306 IRF-5 interacts with MyD88 and TLR stimulation induces nuclear translocation of IRF-5 which regulates the production of several cytokines such as IL-6, IL-12, and TNF-alpha
p33
p33
cso30:i:ME_Translation
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c88 : 1
m93309*0.1
nodelay
--
0
PMID: 18262306 IRF-5 interacts with MyD88 and TLR stimulation induces nuclear translocation of IRF-5 which regulates the production of several cytokines such as IL-6, IL-12, and TNF-alpha
p33
p34
cso30:i:ME_Translation
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c89 : 1
stoichiometry:c90 : 1
m93248*0.1
nodelay
--
0
PMID: 18262306 IRF-5 interacts with MyD88 and TLR stimulation induces nuclear translocation of IRF-5 which regulates the production of several cytokines such as IL-6, IL-12, and TNF-alpha
p33
p35
cso30:i:ME_Translation
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c91 : 1
stoichiometry:c92 : 1
m93589*0.1
nodelay
--
0
PMID: 18262306 IRF-5 interacts with MyD88 and TLR stimulation induces nuclear translocation of IRF-5 which regulates the production of several cytokines such as IL-6, IL-12, and TNF-alpha
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c95 : 1
stoichiometry:c94 : 1
m48*m12*0.1
nodelay
--
0
PMID: 18262306,14716310 TLR9 is originally localized in the ER, and then migrates to the endosome when the cells are stimulated
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c96 : 1
stoichiometry:c97 : 1
stoichiometry:c98 : 1
m49*m21*0.1
nodelay
--
0
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c101 : 1
stoichiometry:c100 : 1
m64*m21*0.1
nodelay
--
0
PMID: 18262306,12626561 Upon B or K-type CpG-DNA stimulation, cDCs and macrophages produce proinflammatory cytokines, such as TNF-alpha, IL-6 and IL-12, and upregulate surface expression of MHC class II and co-stimulatory molecules
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c102 : 1
stoichiometry:c104 : 1
stoichiometry:c103 : 1
m67*m21*0.1
nodelay
--
0
PMID: 18262306,12626561 Upon B or K-type CpG-DNA stimulation, cDCs and macrophages produce proinflammatory cytokines, such as TNF-alpha, IL-6 and IL-12, and upregulate surface expression of MHC class II and co-stimulatory molecules
p4
p4
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1
m3965*m119368*0.1
nodelay
--
0
PMID: 18262306,11607032,14976261,14976262,11812998 TLR3 and 7 (and possibly 8) are involved in the recognition of double-stranded (ds) and single-stranded (ss) RNA, respectively
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c105 : 1
stoichiometry:c107 : 1
stoichiometry:c106 : 1
m68*m21*0.1
nodelay
--
0
PMID: 18262306 cDC produces IL-15 upon TLR9 stimulation
p41
p41
cso30:i:ME_Translation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c108 : 1
stoichiometry:c110 : 1
stoichiometry:c109 : 1
m93494*m1956*0.1
nodelay
--
0
PMID: 18262306 IL-15 in turn activates pDC to express CD40L on its surface.
p42
p42
cso30:i:ME_Translation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c111 : 1
stoichiometry:c113 : 1
stoichiometry:c112 : 1
m93612*m21*0.1
nodelay
--
0
PMID: 18262306 At the same time, TLR9 signaling facilitates expression of CD40 on cDC
p43
p43
cso30:i:ME_Binding
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c114 : 1
stoichiometry:c115 : 1
stoichiometry:c116 : 1
m1837*m70*0.1
nodelay
--
0
PMID: 18262306 Consequently, crosstalk between cDC and pDC via CD40-CD40L ligation leads to production of IL-12 from cDC.
p44
p44
cso30:i:ME_Translation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c117 : 1
stoichiometry:c119 : 1
stoichiometry:c118 : 1
m92*m93589*0.1
nodelay
--
0
PMID: 18262306 Consequently, crosstalk between cDC and pDC via CD40-CD40L ligation leads to production of IL-12 from cDC.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c120 : 1
stoichiometry:c121 : 1
stoichiometry:c122 : 1
m970*m29*0.1
nodelay
--
0
PMID: 18262306,17018642 It was revealed that IRF-1 also interacts with MyD88, and IRF-1, but not IRF-7, and is activated in response to TLR9 stimulation of cDCs to control the expression of IFN-beta
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c123 : 1
stoichiometry:c124 : 1
stoichiometry:c125 : 1
m93*0.1
nodelay
--
0
PMID: 18262306,17018642 It was revealed that IRF-1 also interacts with MyD88, and IRF-1, but not IRF-7, and is activated in response to TLR9 stimulation of cDCs to control the expression of IFN-beta
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c126 : 1
stoichiometry:c127 : 1
m94*0.1
nodelay
--
0
PMID: 18262306,17018642 It was revealed that IRF-1 also interacts with MyD88, and IRF-1, but not IRF-7, and is activated in response to TLR9 stimulation of cDCs to control the expression of IFN-beta
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c128 : 1
stoichiometry:c129 : 1
stoichiometry:c130 : 1
m88*m12*0.1
nodelay
--
0
PMID: 18262306,11130078 TLR9 was first cloned and identified as a receptor for unmethylated CpG-DNA as well as for bacterial DNA in 2000
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c131 : 1
stoichiometry:c132 : 1
stoichiometry:c133 : 1
m99*m98*0.1
nodelay
--
0
PMID: 18262306 MyD88, one of these adaptors containing a TIR domain and a death domain (DD), is known to be essential for initiating TLR9 signaling.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1
m19940*m18*0.1
nodelay
--
0
PMID: 18262306,11607032,14976261,14976262,11812998 TLR3 and 7 (and possibly 8) are involved in the recognition of double-stranded (ds) and single-stranded (ss) RNA, respectively
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c151 : 1
stoichiometry:c152 : 1
stoichiometry:c153 : 1
m980*m110*0.1
nodelay
--
0
PMID: 18262306,15361868 IRF-7 directly interacts with MyD88 and forms a large complex with IRAK-1, IRAK-4 and TRAF6 in pDCs
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c139 : 1
stoichiometry:c141 : 1
m104*0.1
nodelay
--
0
PMID: 18262306 IRF-7 is phosphorylated in the complex and translocates into the nucleus to induce transcription of type I IFNs and IFN-inducible genes.
p52
p52
cso30:i:ME_Translocation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c142 : 1
stoichiometry:c143 : 1
stoichiometry:c154 : 1
m105*0.1
nodelay
--
0
PMID: 18262306 IRF-7 is phosphorylated in the complex and translocates into the nucleus to induce transcription of type I IFNs and IFN-inducible genes.
p53
p53
cso30:i:ME_GeneExpression
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c144 : 1
stoichiometry:c145 : 1
m19325*0.1
nodelay
--
0
PMID: 18262306 IRF-7 is phosphorylated in the complex and translocates into the nucleus to induce transcription of type I IFNs and IFN-inducible genes.
p53
p54
cso30:i:ME_GeneExpression
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c146 : 1
stoichiometry:c147 : 1
m19325*0.1
nodelay
--
0
PMID: 18262306 IRF-7 is phosphorylated in the complex and translocates into the nucleus to induce transcription of type I IFNs and IFN-inducible genes.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c134 : 1
stoichiometry:c135 : 1
stoichiometry:c136 : 1
stoichiometry:c137 : 1
m101*m102*m100*0.1
nodelay
--
0
PMID: 18262306 MyD88 in turn interacts with interleukin-1 receptor-associated kinase-1 (IRAK-1) and IRAK-4 through its DD.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c138 : 1
stoichiometry:c140 : 1
m108*0.1
nodelay
--
0
PMID: 18262306,17485511 IRAK-4 and its kinase activity are shown to be essential for TLR9-mediated cytokine production PMID: 18262306 IRAK-1 is a known substrate of IRAK-4, and phosphorylated IRAK-1 upregulates its kinase activity, and subsequently recruits tumor necrosis factor associated factor 6 (TRAF6).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c148 : 1
stoichiometry:c149 : 1
stoichiometry:c150 : 1
m109*m103*0.1
nodelay
--
0
PMID: 18262306 IRAK-1 is a known substrate of IRAK-4, and phosphorylated IRAK-1 upregulates its kinase activity, and subsequently recruits tumor necrosis factor associated factor 6 (TRAF6).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c155 : 1
stoichiometry:c156 : 1
stoichiometry:c157 : 1
m111*m19828*0.1
nodelay
--
0
PMID: 18262306 TLR9 also recognizes bacterial and viral DNA
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c158 : 1
stoichiometry:c159 : 1
stoichiometry:c160 : 1
m41844*m113*0.1
nodelay
--
0
PMID: 18262306,16424890 Nevertheless, recent studies revealed that cytosolic PRRs called Retinoic acid-inducible gene (RIG-I)-like helicases (RLHs) can recognize viral RNA in the cytosol
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1
m18*m19823*0.1
nodelay
--
0
PMID: 18262306,11607032,14976261,14976262,11812998 TLR3 and 7 (and possibly 8) are involved in the recognition of double-stranded (ds) and single-stranded (ss) RNA, respectively
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c161 : 1
stoichiometry:c162 : 1
stoichiometry:c163 : 1
m76904*m113*0.1
nodelay
--
0
PMID: 18262306,16424890 Nevertheless, recent studies revealed that cytosolic PRRs called Retinoic acid-inducible gene (RIG-I)-like helicases (RLHs) can recognize viral RNA in the cytosol PMID: 18262306 The recognition of viral RNAs by these helicases induces production of type I IFNs and an associated antiviral response.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c165 : 1
stoichiometry:c164 : 1
m115*0.1
nodelay
--
0
PMID: 18262306 The recognition of viral RNAs by these helicases induces production of type I IFNs and an associated antiviral response.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c166 : 1
stoichiometry:c167 : 1
m114*0.1
nodelay
--
0
PMID: 18262306 The recognition of viral RNAs by these helicases induces production of type I IFNs and an associated antiviral response.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c168 : 1
stoichiometry:c169 : 1
stoichiometry:c170 : 1
m36323*m117*0.1
nodelay
--
0
PMID: 18262306,17618271 Recently, a potential cytoplasmic DNA receptor named DAI (also known as DLM1 or ZBP1) was identified
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1
m19828*m12*0.1
nodelay
--
0
PMID: 18262306,11130078 TLR9 was first cloned and identified as a receptor for unmethylated CpG-DNA as well as for bacterial DNA in 2000
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1
m22*m19828*0.1
nodelay
--
0
PMID: 18262306,11130078 TLR9 was first cloned and identified as a receptor for unmethylated CpG-DNA as well as for bacterial DNA in 2000 PMID: 18262306 TLR9 also recognizes bacterial and viral DNA
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1
m24*m19828*0.1
nodelay
--
0
PMID: 18262306,15630134 In addition to DNA, hemozoin (HZ) derived from the malaria parasite Plasmodium acts as a TLR9 ligand
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
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--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
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1,
--
cso30:c:InputAssociation
threshold
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cso30:c:OutputProcess
threshold
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cso30:c:InputAssociation
threshold
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cso30:c:OutputProcess
threshold
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cso30:c:InputAssociation
threshold
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cso30:c:OutputProcess
threshold
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cso30:c:InputProcess
threshold
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1,
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cso30:c:InputProcess
threshold
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cso30:c:InputAssociation
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cso30:c:OutputProcess
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cso30:c:InputProcess
threshold
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cso30:c:InputProcess
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cso30:c:InputProcess
threshold
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cso30:c:InputProcess
threshold
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cso30:c:OutputProcess
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cso30:c:InputProcess
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cso30:c:InputProcess
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cso30:c:InputProcess
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cso30:c:OutputProcess
threshold
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cso30:c:InputProcess
threshold
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cso30:c:OutputProcess
threshold
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cso30:c:OutputProcess
threshold
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cso30:c:InputProcess
threshold
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cso30:c:OutputProcess
threshold
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cso30:c:InputAssociation
threshold
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cso30:c:OutputProcess
threshold
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cso30:c:InputAssociation
threshold
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cso30:c:OutputProcess
threshold
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cso30:c:InputProcess
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cso30:c:OutputProcess
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cso30:c:OutputProcess
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cso30:c:InputProcess
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cso30:c:OutputProcess
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cso30:c:OutputProcess
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cso30:c:InputProcess
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cso30:c:InputProcess
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cso30:c:OutputProcess
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cso30:c:InputProcess
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cso30:c:OutputProcess
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cso30:c:InputProcess
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cso30:c:OutputProcess
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cso30:c:InputAssociation
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cso30:c:InputAssociation
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cso30:c:OutputProcess
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cso30:c:InputProcess
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cso30:c:InputProcess
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cso30:c:OutputProcess
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cso30:c:OutputProcess
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cso30:c:OutputProcess
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cso30:c:OutputProcess
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cso30:c:InputProcess
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cso30:c:InputProcess
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cso30:c:InputProcess
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cso30:c:InputAssociation
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cso30:c:InputAssociation
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cso30:c:InputAssociation
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cso30:c:InputProcess
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cso30:c:InputProcess
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cso30:c:InputAssociation
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cso30:c:InputProcess
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cso30:c:OutputProcess
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cso30:c:InputAssociation
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cso30:c:InputAssociation
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cso30:c:OutputProcess
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cso30:c:InputAssociation
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cso30:c:OutputProcess
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cso30:c:InputAssociation
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cso30:c:OutputProcess
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cso30:c:InputAssociation
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cso30:c:OutputProcess
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cso30:c:InputProcess
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cso30:c:OutputProcess
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cso30:c:InputProcess
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cso30:c:OutputProcess
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cso30:c:InputAssociation
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cso30:c:OutputProcess
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cso30:c:InputAssociation
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cso30:c:OutputProcess
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cso30:c:InputAssociation
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cso30:c:OutputProcess
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cso30:c:InputAssociation
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cso30:c:InputAssociation
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cso30:c:OutputProcess
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cso30:c:InputAssociation
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cso30:c:InputAssociation
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1,
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cso30:c:InputProcess
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0
1,
--
cso30:c:InputAssociation
threshold
--
0
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--