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Macrophages incubated in medium containing lipo-MDP increased DNA fragmentation.</csml:comment>
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<csml:comment type="text">PMID: 18251777
These results imply that the intralysosomal accumulation of MDP generates signals to induce macrophage apoptosis.</csml:comment>
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<csml:comment type="text">Indirect</csml:comment>
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<csml:comment type="text">PMID: 18251777
Heme oxygenase 1 (HO-1) in macrophages and hepatocytes plays a key role in bilirubin metabolism. Senescent or denatured erythrocytes incorporated by Kupffer cells and non-heme protein in hepatocytes are a major source of bilirubin.</csml:comment>
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<csml:comment type="text">PMID: 18251777
The effects of M-CSF are mediated by the M-CSF receptor (M-CSFR), encoded by the c-fms proto-oncogene.</csml:comment>
</csml:comments>
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<csml:comments>
<csml:comment type="text">PMID: 18251777, 8426088
These results indicate that the differentiation and maturation of tissue macrophages are mediated by M-CSF, but dendritic cell differentiation is controlled by other factor(s) than M-CSF, most probably by GM-CSF.</csml:comment>
</csml:comments>
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<csml:comments>
<csml:comment type="text">PMID: 18251777, 8426088
These results indicate that the differentiation and maturation of tissue macrophages are mediated by M-CSF, but dendritic cell differentiation is controlled by other factor(s) than M-CSF, most probably by GM-CSF.

PMID: 18251777
GM-CSF is also a hematopoietic growth factor that stimulates the survival, proliferation, differentiation, and function of myeloid cells and their precursors, particularly neutrophils and monocyte/macrophages.</csml:comment>
</csml:comments>
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<csml:comment type="text">PMID: 18251777
GM-CSF acts as a stimulator of terminal differentiation of alveolar macrophages, principally through PU.1 expression.</csml:comment>
</csml:comments>
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<csml:comments>
<csml:comment type="text">PMID: 18251777
GM-CSF acts as a stimulator of terminal differentiation of alveolar macrophages, principally through PU.1 expression.

PMID: 18251777
Thus, GM-CSF acts as a stimulator of terminal differentiation of alveolar macrophages, principally through PU.1 expression.</csml:comment>
</csml:comments>
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<csml:comment type="text">PMID: 18251777
After LPS administration cytokine production and the expression of LPS receptors, such as CD14 and macrophage scavenger receptor class A (MSR-A), were induced at lower levels in op/op mice than in littermate mice, indicating that deficient macrophage activation following LPS injection in op/op mice is associated with the decreased expression of CD14 and MSR-A in the liver.</csml:comment>
</csml:comments>
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<csml:comment type="text">PMID: 18251777
After LPS administration cytokine production and the expression of LPS receptors, such as CD14 and macrophage scavenger receptor class A (MSR-A), were induced at lower levels in op/op mice than in littermate mice, indicating that deficient macrophage activation following LPS injection in op/op mice is associated with the decreased expression of CD14 and MSR-A in the liver.</csml:comment>
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<csml:comment type="text">PMID: 18251777
After LPS administration cytokine production and the expression of LPS receptors, such as CD14 and macrophage scavenger receptor class A (MSR-A), were induced at lower levels in op/op mice than in littermate mice, indicating that deficient macrophage activation following LPS injection in op/op mice is associated with the decreased expression of CD14 and MSR-A in the liver.</csml:comment>
</csml:comments>
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<csml:comment type="text">PMID: 18251777
GM-CSF is also a hematopoietic growth factor that stimulates the survival, proliferation, differentiation, and function of myeloid cells and their precursors, particularly neutrophils and monocyte/macrophages.</csml:comment>
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<csml:comments>
<csml:comment type="text">PMID: 18251777
GM-CSF is also a hematopoietic growth factor that stimulates the survival, proliferation, differentiation, and function of myeloid cells and their precursors, particularly neutrophils and monocyte/macrophages.</csml:comment>
</csml:comments>
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Complement receptor type 3 (CR3) and the receptor of internalin A (InlA) mediate the uptake of Listeria.</csml:comment>
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Type I and type II MSR-A recognize a variety of polyanions such as chemically modified lipoproteins, LPS of Gramnegative bacteria, and lipoteichoic acid of Gram-positive bacteria, suggesting a role in host defense.

PMID: 18251777
LPS is known to bind to several receptors on macrophages, including CD14 and MSR-A, and stimulates macrophages to release various nflammatory mediators.</csml:comment>
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LPS is known to bind to several receptors on macrophages, including CD14 and MSR-A, and stimulates macrophages to release various nflammatory mediators.</csml:comment>
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Type I and type II MSR-A recognize a variety of polyanions such as chemically modified lipoproteins, LPS of Gramnegative bacteria, and lipoteichoic acid of Gram-positive bacteria, suggesting a role in host defense.</csml:comment>
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Type I and type II MSR-A recognize a variety of polyanions such as chemically modified lipoproteins, LPS of Gramnegative bacteria, and lipoteichoic acid of Gram-positive bacteria, suggesting a role in host defense.</csml:comment>
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LPS-induced expression of cytokines in the liver was similar in MSR-A+/+and MSR-A-/– mice, but levels of IL-1beta expression and serum IL-1beta were lower in MSR-A-/– mice.</csml:comment>
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<csml:comment type="text">PMID: 18251777
LPS-induced expression of cytokines in the liver was similar in MSR-A+/+and MSR-A-/– mice, but levels of IL-1beta expression and serum IL-1beta were lower in MSR-A-/– mice.</csml:comment>
</csml:comments>
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<csml:comment type="text">PMID: 18251777, 7867067
A class A type III macrophage receptor with a collagenous structure (MARCO) is a trimeric membrane glycoprotein mediating the uptake of chemically modified low-density lipoproteins.</csml:comment>
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<csml:comment type="text">PMID: 18251777
Expression of scavenger receptors is enhanced by macrophage colony-stimulating factor (M-CSF) and granulocyte–macrophage colony-stimulating factor (GM-CSF).</csml:comment>
</csml:comments>
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<csml:comment type="text">PMID: 18251777
Expression of scavenger receptors is enhanced by macrophage colony-stimulating factor (M-CSF) and granulocyte–macrophage colony-stimulating factor (GM-CSF).</csml:comment>
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Scavenger receptors uptake oxidized low-density lipoprotein (oxLDL) and intracellular accumulation of cholesterol stimulate LXRalpha.</csml:comment>
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Scavenger receptors uptake oxidized low-density lipoprotein (oxLDL) and intracellular accumulation of cholesterol stimulate LXRalpha.</csml:comment>
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Scavenger receptors uptake oxidized low-density lipoprotein (oxLDL) and intracellular accumulation of cholesterol stimulate LXRalpha.</csml:comment>
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This modified enzyme is endocytosed after it binds to cell-surface mannose receptors and is subsequently delivered to lysosomes where it supplements the defective enzyme.</csml:comment>
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<csml:comment type="text">PMID: 18251777
Liver X receptors (LXR) are also involved in cholesterol metabolism in macrophages.</csml:comment>
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LXR are nuclear receptors initially identified in the liver that form a functional heterodimer with the retinoid X receptor (RXR) to recognize and bind to its hormone response elements.</csml:comment>
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LXR are nuclear receptors initially identified in the liver that form a functional heterodimer with the retinoid X receptor (RXR) to recognize and bind to its hormone response elements.</csml:comment>
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LXR are activated by a number of oxidized derivatives of cholesterol (oxysterols) and promote the synthesis of ABCA1 and other transporters, which reduce  intracellular levels of cholesterol and thus protect against atherosclerosis.</csml:comment>
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<csml:comment type="text">PMID: 18251777, 9794827, 12449021, 12193651
LXR are activated by a number of oxidized derivatives of cholesterol (oxysterols) and promote the synthesis of ABCA1 and other transporters, which reduce  intracellular levels of cholesterol and thus protect against atherosclerosis.

PMID: 18251777
A potent TLR3 agonist, poly I:C, and a TLR4 agonist, lipid A, selectively inhibit the synthesis of ABCA1 and other cholesterol efflux mediators, when macrophages are stimulated with synthetic LXR agonists.</csml:comment>
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<csml:comment type="text">PMID: 18251777
We also confirmed that LXRa expression was markedly decreased in the rat liver after zymosan injection and we therefore cultured human monocytes in the presence of LPS or zymosan.</csml:comment>
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Complement receptor type 3 (CR3) and the receptor of internalin A (InlA) mediate the uptake of Listeria.</csml:comment>
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