Entity
--
e1
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane
--
--
--
csml-variable:Double
m1
0
infinite
0
--
--
e10
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytosol
--
--
--
csml-variable:Double
m10
0
infinite
0
--
TCR ligand:TCR:Zap-70:IRAK-4
--
e100
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m100
0
infinite
0
--
Zap-70
--
e101
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m101
0
infinite
0
--
PKC{active}
--
e102
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m102
0
infinite
0
--
PKC
--
e103
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m103
0
infinite
0
--
TAK1
--
e11
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m11
0
infinite
0
--
TLR ligand:TLR
--
e12
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m12
0
infinite
0
--
TLR
--
e13
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m13
0
infinite
0
--
TLR ligand
--
e14
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m14
0
infinite
0
--
MYD88
--
e15
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m15
0
infinite
0
--
TLR ligand:TLR:MYD88
--
e16
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m16
0
infinite
0
--
IRAK-1
--
e17
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m17
0
infinite
0
--
Tollip
--
e18
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m18
0
infinite
0
--
TRAF
--
e19
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m19
0
infinite
0
--
--
e2
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m2
0
infinite
0
--
TLR ligand:TLR:MYD88:IRAK-1:TRAF:Tollip:IRAK4
--
e20
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m20
0
infinite
0
--
IkappaB-alpha:p50:p65
--
e21
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m21
0
infinite
0
--
IkappaB-alpha:p50:p65
--
e22
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m22
0
infinite
0
--
IKK complex
--
e23
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m23
0
infinite
0
--
protein remnants
--
e24
cso30:c:EntityBiological
cso30:i:CC_Cytosol
--
csml-variable:Double
m24
0
infinite
0
--
p50:p65
--
e25
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m25
0
infinite
0
--
p50:p65{p}
--
e26
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m26
0
infinite
0
--
IKK-epsilon
--
e27
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m27
0
infinite
0
--
IKK-epsilon
--
e28
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m28
0
infinite
0
--
p50:p65{p}
--
e29
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m29
0
infinite
0
--
--
e3
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
--
csml-variable:Double
m3
0
infinite
0
--
IRF-5
--
e30
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m30
0
infinite
0
--
IRF-5{p}
--
e31
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m31
0
infinite
0
--
IRF-7{p}
--
e32
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m32
0
infinite
0
--
IRF-7
--
e33
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m33
0
infinite
0
--
TNF-alpha
--
e34
cso30:c:mRNA
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m34
0
infinite
0
--
IFNA4
--
e36
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
--
csml-variable:Double
m36
0
infinite
0
--
IRAK-1{active}
--
e37
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m37
0
infinite
0
--
TLR7 ligand
--
e38
cso30:c:SmallMolecule
cso30:i:CC_Cytosol
--
csml-variable:Double
m38
0
infinite
0
--
TLR9 ligand
--
e39
cso30:c:SmallMolecule
cso30:i:CC_Cytosol
--
csml-variable:Double
m39
0
infinite
0
--
--
e4
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m4
0
infinite
0
--
TLR8 ligand
--
e40
cso30:c:SmallMolecule
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m40
0
infinite
0
--
NF-kappaB
--
e41
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m41
0
infinite
0
--
NF-kappaB{active}
--
e42
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m42
0
infinite
0
--
caveolin
--
e43
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m43
0
infinite
0
--
IRAK-1:caveolin
--
e44
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m44
0
infinite
0
--
CD26
--
e45
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m45
0
infinite
0
--
CD86
--
e46
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
--
csml-variable:Double
m46
0
infinite
0
--
IRAK-4
--
e47
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m47
0
infinite
0
--
TLR ligand:TLR:MYD88:IRAK-1{p}:TRAF:Tollip:IRAK4
--
e48
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m48
0
infinite
0
--
TLR ligand:TLR:MYD88:TRAF:Tollip:IRAK4
--
e49
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m49
0
infinite
0
--
P47phox
--
e5
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m5
0
infinite
0
--
--
e50
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelopeLumen
--
--
--
csml-variable:Double
m50
0
infinite
0
--
--
e51
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearPore
--
--
--
csml-variable:Double
m51
0
infinite
0
--
--
e52
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearInnerMembrane
--
--
--
csml-variable:Double
m52
0
infinite
0
--
--
e53
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearLumen
--
--
--
csml-variable:Double
m53
0
infinite
0
--
--
e54
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearOuterMembrane
--
--
--
csml-variable:Double
m54
0
infinite
0
--
--
e55
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleus
--
--
--
csml-variable:Double
m55
0
infinite
0
--
--
e56
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleoplasm
--
--
--
csml-variable:Double
m56
0
infinite
0
--
--
e57
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearBody
--
--
--
csml-variable:Double
m57
0
infinite
0
--
--
e58
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleolus
--
--
--
csml-variable:Double
m58
0
infinite
0
--
--
e59
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelope
--
--
--
csml-variable:Double
m59
0
infinite
0
--
p47phox{p}
--
e6
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m6
0
infinite
0
--
--
e60
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Chromatin
--
--
--
csml-variable:Double
m60
0
infinite
0
--
--
e61
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearChromosome
--
--
--
csml-variable:Double
m61
0
infinite
0
--
--
e62
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearCentromere
--
--
--
csml-variable:Double
m62
0
infinite
0
--
TLR ligand:TLR:MYD88:IRAK-1{p}:TRAF:Tollip:IRAK4
--
e63
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m63
0
infinite
0
--
TLR ligand:TLR:MYD88:IRAK-1{p}{ub}:TRAF:Tollip:IRAK4
--
e64
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m64
0
infinite
0
--
LPS:TLR4
--
e65
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m65
0
infinite
0
--
TLR4
--
e66
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m66
0
infinite
0
--
LPS
--
e67
cso30:c:SmallMolecule
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m67
0
infinite
0
--
LPS:TLR4:MYD88:IRAK4:IRAK1
--
e68
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m68
0
infinite
0
--
LPS:TLR4:MYD88:IRAK4:IRAK1
--
e69
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m69
0
infinite
0
--
--
e7
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell
--
--
--
csml-variable:Double
m7
0
infinite
0
--
IRAK-1{sumo}
--
e70
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m70
0
infinite
0
--
LPS:TLR4:MYD88:IRAK4
--
e71
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m71
0
infinite
0
--
Stat3
--
e72
cso30:c:Protein
cso30:i:CC_Nucleoplasm
--
--
csml-variable:Double
m72
0
infinite
0
--
Stat3{active}
--
e73
cso30:c:Protein
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m73
0
infinite
0
--
gene
--
e74
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m74
0
infinite
0
--
IL-1beta
--
e75
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m75
0
infinite
0
--
csml-variable:Double
m76
0
infinite
0
--
MAPK{active}
--
e77
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m77
0
infinite
0
--
IRAK-1c
--
e78
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m78
0
infinite
0
--
IRAK-2
--
e79
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m79
0
infinite
0
--
--
e8
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell_WithoutCellWall_
--
--
--
csml-variable:Double
m8
0
infinite
0
--
TRAF6
--
e80
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m80
0
infinite
0
--
TLR ligand:TLR:MYD88:IRAK-2:TRAF6:IRAK4
--
e81
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m81
0
infinite
0
--
Mal
--
e82
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m82
0
infinite
0
--
TLR ligand:TLR:MAL:IRAK2
--
e83
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m83
0
infinite
0
--
TLR ligand:TLR:MYD88:IRAK-2:TRAF6{ub}:IRAK4
--
e84
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m84
0
infinite
0
--
IRAK-2a
--
e85
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m85
0
infinite
0
--
IRAK-2b
--
e86
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m86
0
infinite
0
--
IRAK-2c
--
e87
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m87
0
infinite
0
--
IRAK-2d
--
e88
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m88
0
infinite
0
--
TAK1{active}
--
e89
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m89
0
infinite
0
--
--
e9
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytoplasm
--
--
--
csml-variable:Double
m9
0
infinite
0
--
IKK complex
--
e90
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m90
0
infinite
0
--
NIK
--
e91
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m91
0
infinite
0
--
NIK{active}
--
e92
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m92
0
infinite
0
--
IRAK-M
--
e93
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m93
0
infinite
0
--
IkappaB-alpha
--
e94
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m94
0
infinite
0
--
csml-variable:Double
m95
0
infinite
0
--
csml-variable:Double
m96
0
infinite
0
--
IkappaB-alpha:p50:p65
--
e97
cso30:c:Complex
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m97
0
infinite
0
--
inflammatory mediators
--
e98
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
--
csml-variable:Double
m98
0
infinite
0
--
TCR ligand:TCR
--
e99
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m99
0
infinite
0
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c3 : 1
stoichiometry:c2 : 1
m5*m47*0.1
nodelay
--
0
PMID: 18249132, 17217339 IRAK-4 was shown to phosphorylate NADPH oxidase p47phox and contribute to cellular oxidative response in neutrophils.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c31 : 1
stoichiometry:c30 : 1
m30*m20*0.1
nodelay
--
0
PMID: 18249132, 15767370, 15695821 Perhaps one of the major functions of IRAK-1 is to mediate the ligand-stimulated phosphorylation of IRF5/7.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1
stoichiometry:c34 : 1
stoichiometry:c33 : 1
m33*m20*0.1
nodelay
--
0
PMID: 18249132, 15767370, 15695821 Perhaps one of the major functions of IRAK-1 is to mediate the ligand-stimulated phosphorylation of IRF5/7.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c36 : 1
m42*0.1
nodelay
--
0
PMID: 18249132, 15767370 In contrast, NF¦ÊB-mediated gene expressions such as TNF¦Á seem to be un-altered in IRAK-1¡Ý/¡Ý cells upon challenge with agonists for TLR 7/8 as well as TLR9
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c37 : 1
m37*0.1
nodelay
--
0
PMID: 18249132 Consequently, interferon alpha4 gene expression is dramatically decreased in IRAK-1¡Ý/¡Ý cells following the stimulation with TLR7 and TLR9 ligand.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c43 : 1
stoichiometry:c39 : 1
m17*m39*0.1
nodelay
--
0
PMID: 18249132 Consequently, interferon alpha4 gene expression is dramatically decreased in IRAK-1¡Ý/¡Ý cells following the stimulation with TLR7 and TLR9 ligand.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c41 : 1
stoichiometry:c42 : 1
stoichiometry:c40 : 1
m17*m38*0.1
nodelay
--
0
PMID: 18249132 Consequently, interferon alpha4 gene expression is dramatically decreased in IRAK-1¡Ý/¡Ý cells following the stimulation with TLR7 and TLR9 ligand.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c123 : 1
stoichiometry:c125 : 1
stoichiometry:c129 : 1
stoichiometry:c124 : 1
m91*m84*0.1
nodelay
--
0
PMID: 18249132 From fig.2 PMID: 18249132, 17892204 we have observed that IRAK-M primarily affects the alternative NIK-IKK¦Á/IKK¦Á-RelB NF¦ÊB pathway, instead of the classical TAK1-IKK¦Á/IKK¦Â-RelA pathway
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c53 : 1
stoichiometry:c50 : 1
m41*m39*0.1
nodelay
--
0
PMID: 18249132, 15767370 In contrast, NF¦ÊB-mediated gene expressions such as TNF¦Á seem to be un-altered in IRAK-1¡Ý/¡Ý cells upon challenge with agonists for TLR 7/8 as well as TLR9.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c52 : 1
stoichiometry:c49 : 1
m41*m38*0.1
nodelay
--
0
PMID: 18249132, 15767370 In contrast, NF¦ÊB-mediated gene expressions such as TNF¦Á seem to be un-altered in IRAK-1¡Ý/¡Ý cells upon challenge with agonists for TLR 7/8 as well as TLR9.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c51 : 1
stoichiometry:c48 : 1
m41*m40*0.1
nodelay
--
0
PMID: 18249132, 15767370 In contrast, NF¦ÊB-mediated gene expressions such as TNF¦Á seem to be un-altered in IRAK-1¡Ý/¡Ý cells upon challenge with agonists for TLR 7/8 as well as TLR9.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1
m14*m13*0.1
nodelay
--
0
PMID: 18249132 Figure 1
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c55 : 1
stoichiometry:c57 : 1
stoichiometry:c56 : 1
m17*m43*m45*0.1
nodelay
--
0
PMID: 18249132, 16107720 T cell co-stimulatory molecule CD26 can trigger the association of IRAK-1 with caveolin on antigen presenting monocytes, which is responsible for the subsequent expression of co-stimulatory molecule CD86.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c58 : 1
m44*0.1
nodelay
--
0
PMID: 18249132, 16107720 T cell co-stimulatory molecule CD26 can trigger the association of IRAK-1 with caveolin on antigen presenting monocytes, which is responsible for the subsequent expression of co-stimulatory molecule CD86.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c62 : 1
m20*0.1
nodelay
--
0
PMID: 18249132, 17161373 Upstream kinases such as IRAK-4 may contribute to the initial phosphorylation of IRAK-1 at Threonine 381
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c63 : 1
stoichiometry:c64 : 1
m48*0.1
nodelay
--
0
PMID: 18249132 Following such event, IRAK-1 can be quickly activated and exhibit self-phosphorylation within its Pro/Ser rich region
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c66 : 1
m63*0.1
nodelay
--
0
PMID: 18249132 This self-phosphorylation may subject the IRAK-1 molecule to subsequent ubiquitination and proteosome-mediated degradation.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c68 : 1
stoichiometry:c69 : 1
m64*0.1
nodelay
--
0
PMID: 18249132 This self-phosphorylation may subject the IRAK-1 molecule to subsequent ubiquitination and proteosome-mediated degradation.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1
stoichiometry:c72 : 1
stoichiometry:c71 : 1
m66*m67*0.1
nodelay
--
0
PMID: 18249132, 16690127, 15465816 IRAK-1 also gets sumoylated following either LPS or Pam3CSK4 challenge.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c74 : 1
stoichiometry:c75 : 1
stoichiometry:c76 : 1
stoichiometry:c77 : 1
m65*m15*m17*m47*0.1
nodelay
--
0
PMID: 18249132, 16690127, 15465816 IRAK-1 also gets sumoylated following either LPS or Pam3CSK4 challenge. PMID: 18249132, 11960013 MyD88 is critically involved in recruiting IRAK-4 into the TLR4 complex
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c78 : 1
stoichiometry:c79 : 1
m68*0.1
nodelay
--
0
PMID: 18249132, 16690127, 15465816 IRAK-1 also gets sumoylated following either LPS or Pam3CSK4 challenge.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c80 : 1
stoichiometry:c81 : 1
stoichiometry:c82 : 1
m69*0.1
nodelay
--
0
PMID: 18249132, 15465816 Sumoylated IRAK-1 enters the nucleus and contributes to Stat3 activation and selected gene expression
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1
m12*m15*0.1
nodelay
--
0
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c85 : 1
stoichiometry:c84 : 1
m72*m70*0.1
nodelay
--
0
PMID: 18249132, 15465816 Sumoylated IRAK-1 enters the nucleus and contributes to Stat3 activation and selected gene expression
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c87 : 1
m73*0.1
nodelay
--
0
PMID: 18249132, 15465816 Sumoylated IRAK-1 enters the nucleus and contributes to Stat3 activation and selected gene expression
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c88 : 1
stoichiometry:c90 : 1
stoichiometry:c91 : 1
stoichiometry:c89 : 1
m76*m75*0.1
nodelay
--
0
PMID: 18249132 Overexpression of IRAK-1c blocks IL-1¦Â induced MAP kinase activation, suggesting that IRAK-1c may serve as a negative regulator of inflammation.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c92 : 1
stoichiometry:c93 : 1
stoichiometry:c94 : 1
stoichiometry:c95 : 1
stoichiometry:c116 : 1
stoichiometry:c96 : 1
m12*m15*m79*m80*m47*0.1
nodelay
--
0
PMID: 18249132 Upon overexpression, IRAK-2 can associate with MyD88 as well as TRAF6, and activate NF¦ÊB-dependent reporter gene expression.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c97 : 1
stoichiometry:c99 : 1
stoichiometry:c98 : 1
m41*m84*0.1
nodelay
--
0
PMID: 18249132 Upon overexpression, IRAK-2 can associate with MyD88 as well as TRAF6, and activate NF¦ÊB-dependent reporter gene expression. PMID: 18249132, 17878161 A recent study further confirmed that indeed IRAK-2 instead of IRAK-1 is primarily involved in TRAF-6 ubiquitination and NF¦ÊB activation
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c100 : 1
stoichiometry:c101 : 1
m42*0.1
nodelay
--
0
PMID: 18249132 Upon overexpression, IRAK-2 can associate with MyD88 as well as TRAF6, and activate NF¦ÊB-dependent reporter gene expression.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c102 : 1
stoichiometry:c103 : 1
stoichiometry:c104 : 1
stoichiometry:c105 : 1
m12*m79*m82*0.1
nodelay
--
0
PMID: 18249132, 11544529 IRAK-2, instead of IRAK-1 can also interact with another distinct TLR intracellular adaptor molecule Mal/TIRAP
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c107 : 1
m81*0.1
nodelay
--
0
PMID: 18249132, 17878161 A recent study further confirmed that indeed IRAK-2 instead of IRAK-1 is primarily involved in TRAF-6 ubiquitination and NF¦ÊB activation
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c110 : 1
stoichiometry:c113 : 1
stoichiometry:c111 : 1
m41*m85*0.1
nodelay
--
0
PMID: 18249132 Upon overexpression, IRAK-2a and IRAK-2b can activate, while IRAK-2c and IRAK-2d inhibit NF¦ÊB activation.
p39
p39
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c108 : 1
stoichiometry:c112 : 1
stoichiometry:c114 : 1
stoichiometry:c115 : 1
stoichiometry:c109 : 1
m41*m86*0.1
nodelay
--
0
PMID: 18249132 Upon overexpression, IRAK-2a and IRAK-2b can activate, while IRAK-2c and IRAK-2d inhibit NF¦ÊB activation.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c12 : 1
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c60 : 1
stoichiometry:c11 : 1
m16*m18*m19*m17*m47*0.1
nodelay
--
0
PMID: 18249132 From fig.1
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c117 : 1
stoichiometry:c119 : 1
stoichiometry:c118 : 1
m11*m84*0.1
nodelay
--
0
PMID: 18249132 From fig.2
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c120 : 1
stoichiometry:c122 : 1
stoichiometry:c121 : 1
m90*m89*0.1
nodelay
--
0
PMID: 18249132 From fig.2
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c126 : 1
stoichiometry:c128 : 1
stoichiometry:c127 : 1
m90*m92*0.1
nodelay
--
0
PMID: 18249132 From fig.2
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c130 : 1
stoichiometry:c131 : 1
m29*0.1
nodelay
--
0
PMID: 18249132 From fig.2
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c133 : 1
stoichiometry:c132 : 1
m94*0.1
nodelay
--
0
PMID: 18249132 From fig.2
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c134 : 1
stoichiometry:c135 : 1
m95*0.1
nodelay
--
0
PMID: 18249132 From fig.2
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c136 : 1
stoichiometry:c137 : 1
stoichiometry:c138 : 1
m29*m96*0.1
nodelay
--
0
PMID: 18249132 From fig.2
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c139 : 1
stoichiometry:c140 : 1
m97*0.1
nodelay
--
0
PMID: 18249132 From fig.2
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c142 : 1
stoichiometry:c141 : 1
m29*0.1
nodelay
--
0
PMID: 18249132 From fig.2
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c143 : 1
stoichiometry:c144 : 1
stoichiometry:c146 : 1
stoichiometry:c145 : 1
m99*m47*m101*0.1
nodelay
--
0
PMID: 18249132 Upon TCR stimulation, IRAK-4 is recruited to T cell lipid rafts, where it can associate with Zap70 and activate protein kinase C.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c17 : 1
stoichiometry:c16 : 1
m21*m23*0.1
nodelay
--
0
PMID: 18249132 The first step involves the classical pathway causing the activation of IKK¦Á/¦Â complex, which contributes to I¦ÊB¦Á phosphorylation and degradation, and subsequent nuclear translocation of p65/RelA.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c147 : 1
stoichiometry:c149 : 1
stoichiometry:c148 : 1
m103*m100*0.1
nodelay
--
0
PMID: 18249132 Upon TCR stimulation, IRAK-4 is recruited to T cell lipid rafts, where it can associate with Zap70 and activate protein kinase C.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c150 : 1
stoichiometry:c152 : 1
stoichiometry:c151 : 1
m41*m100*0.1
nodelay
--
0
PMID: 18249132, 16574867 IRAK-4 is also critically involved in T cell receptor (TCR)-induced T cell proliferation through NF¦ÊB activation
PMID: 18249132, 16574867 IRAK-4 is also critically involved in T cell receptor (TCR)-induced T cell proliferation through NF¦ÊB activation
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c18 : 1
stoichiometry:c19 : 1
stoichiometry:c20 : 1
m22*0.1
nodelay
--
0
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c21 : 1
stoichiometry:c23 : 1
stoichiometry:c22 : 1
m25*m27*0.1
nodelay
--
0
PMID: 18249132 The second step involves IKK¦Å/TBK-1 dependent p65/RelA phosphorylation, which is independent of the classical pathway and I¦ÊB¦Á degradation.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c24 : 1
stoichiometry:c26 : 1
stoichiometry:c25 : 1
m28*m20*0.1
nodelay
--
0
PMID: 18249132 Figure 1 PMID: 18249132 Recent evidence indicates that IRAK-1 contributes to NF¦ÊB activation by facilitating p65/RelA phosphorylation, but not the classical pathway leading to I¦ÊB¦Á degradation and p65 nuclear translocation
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c27 : 1
stoichiometry:c28 : 1
m26*0.1
nodelay
--
0
PMID: 18249132 The first step involves the classical pathway causing the activation of IKK¦Á/¦Â complex, which contributes to I¦ÊB¦Á phosphorylation and degradation, and subsequent nuclear translocation of p65/RelA.
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--