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indirect
PMID: 18249034,15032573
In
particular, mannose- and fucose-specific CLRs, such as
dendritic cell-specific intercellular-grabbing nonintegrin
(DC-SIGN) and the mannose receptor (MR), are well
characterized on the basis of their carbohydrate specificity
and function within the immune system
PMID: 18249034
Within the last few years, numerous C-type lectin
receptors (CLRs), which recognize carbohydrate structures
in a Ca2+-dependent manner, have been identified
indirect
PMID: 18249034,15032573
In
particular, mannose- and fucose-specific CLRs, such as
dendritic cell-specific intercellular-grabbing nonintegrin
(DC-SIGN) and the mannose receptor (MR), are well
characterized on the basis of their carbohydrate specificity
and function within the immune system
PMID: 18249034
Within the last few years, numerous C-type lectin
receptors (CLRs), which recognize carbohydrate structures
in a Ca2+-dependent manner, have been identified
indirect
PMID: 18249034,15032573
In
particular, mannose- and fucose-specific CLRs, such as
dendritic cell-specific intercellular-grabbing nonintegrin
(DC-SIGN) and the mannose receptor (MR), are well
characterized on the basis of their carbohydrate specificity
and function within the immune system
PMID: 18249034
Within the last few years, numerous C-type lectin
receptors (CLRs), which recognize carbohydrate structures
in a Ca2+-dependent manner, have been identified
PMID: 18249034,3768888
In the 1980s, Kawasaki et al. discovered that rat peritoneal
macrophages expressed a Ca2+-dependent lectin,
distinct from the hepatic ASGP-R, with specificity for
galactose and GalNAc
PMID: 18249034,2358462
Based on its binding properties,
the lectin was isolated and characterized as rat MGL
(rMGL) or macrophage asialoglycoprotein-binding protein
(M-ASGP-BP)
PMID: 18249034
MGL displays an exclusive
specificity for terminal a- and b-linked GalNAc residues
that naturally occur on glycoproteins or glycosphingolipids
PMID: 18249034
MGL displays an exclusive
specificity for terminal a- and b-linked GalNAc residues
that naturally occur on glycoproteins or glycosphingolipids
PMID: 18249034,17195076,15802303
Specific glycans containing terminal GalNAc moieties,
expressed by the human helminth parasite Schistosoma
mansoni as well as by the tumor antigen MUC1 and
the gangliosides GM2 and GD2, were identified as ligands
for MGL
PMID: 18249034,17195076,15802303
Specific glycans containing terminal GalNAc moieties,
expressed by the human helminth parasite Schistosoma
mansoni as well as by the tumor antigen MUC1 and
the gangliosides GM2 and GD2, were identified as ligands
for MGL
PMID: 18249034,17195076,15802303
Specific glycans containing terminal GalNAc moieties,
expressed by the human helminth parasite Schistosoma
mansoni as well as by the tumor antigen MUC1 and
the gangliosides GM2 and GD2, were identified as ligands
for MGL
PMID: 18249034,17195076,15802303
Specific glycans containing terminal GalNAc moieties,
expressed by the human helminth parasite Schistosoma
mansoni as well as by the tumor antigen MUC1 and
the gangliosides GM2 and GD2, were identified as ligands
for MGL
PMID: 18249034,15262963,7496141
Whereas MGL recognizes only GalNAc
structures, ASGP-R preferentially interacts with tri- or
tetra-antennary glycans containing both galactose or GalNAc residues
PMID: 18249034,15262963,7496141
Whereas MGL recognizes only GalNAc
structures, ASGP-R preferentially interacts with tri- or
tetra-antennary glycans containing both galactose or GalNAc residues
PMID: 18249034,15364954
The macrophagespecific
receptor sialoadhesin has been identified as a selfligand
for mMGL1, and it probably regulates the cellular
localization of mMGL1pos cells within LNs
PMID: 18249034
MGL recognizes all CD45
isoforms, except CD45RO.
PMID: 18249034
MGL recognizes all CD45
isoforms, except CD45RO.
PMID: 18249034
MGL recognizes all CD45
isoforms, except CD45RO.
PMID: 18249034
MGL recognizes all CD45
isoforms, except CD45RO.