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PMID: 18243041, 10201943, 11000131, 8941660
low molecular weight fragments of hyaluronan increase the expression of matrix metalloproteinase (MMP)-12, plasminogen activator inhibitor (PAI)-1 and stimulate the production of several cytokines, including MIP-1alpha, MIP-1beta, MCP-1, KC, IL-8, and IL-12 by macrophages.</csml:comment>
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PMID: 18243041, 10201943, 11000131, 8941660
low molecular weight fragments of hyaluronan increase the expression of matrix metalloproteinase (MMP)-12, plasminogen activator inhibitor (PAI)-1 and stimulate the production of several cytokines, including MIP-1alpha, MIP-1beta, MCP-1, KC, IL-8, and IL-12 by macrophages.</csml:comment>
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PMID: 18243041, 10201943, 11000131, 8941660
low molecular weight fragments of hyaluronan increase the expression of matrix metalloproteinase (MMP)-12, plasminogen activator inhibitor (PAI)-1 and stimulate the production of several cytokines, including MIP-1alpha, MIP-1beta, MCP-1, KC, IL-8, and IL-12 by macrophages.</csml:comment>
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PMID: 18243041, 10201943, 11000131, 8941660
low molecular weight fragments of hyaluronan increase the expression of matrix metalloproteinase (MMP)-12, plasminogen activator inhibitor (PAI)-1 and stimulate the production of several cytokines, including MIP-1alpha, MIP-1beta, MCP-1, KC, IL-8, and IL-12 by macrophages.</csml:comment>
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PMID: 18243041, 10201943, 11000131, 8941660
low molecular weight fragments of hyaluronan increase the expression of matrix metalloproteinase (MMP)-12, plasminogen activator inhibitor (PAI)-1 and stimulate the production of several cytokines, including MIP-1alpha, MIP-1beta, MCP-1, KC, IL-8, and IL-12 by macrophages.</csml:comment>
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PMID: 18243041, 10201943, 11000131, 8941660
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PMID: 18243041, 10201943, 11000131, 8941660
low molecular weight fragments of hyaluronan increase the expression of matrix metalloproteinase (MMP)-12, plasminogen activator inhibitor (PAI)-1 and stimulate the production of several cytokines, including MIP-1alpha, MIP-1beta, MCP-1, KC, IL-8, and IL-12 by macrophages.</csml:comment>
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PMID: 18243041, 10201943, 11000131, 8941660
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PMID: 18243041
The identity of this receptor protein, commonly called the elastin-binding protein (EBP), has been established as an enzymatically inactive, alternatively spliced variant of beta-galactosidase.

PMID: 18243041
This protein binds the X-Gly-X-X-Pro-Gly (XGXXPG) motif in ECM proteins, such as elastin, laminins, collagen type IV, and fibrillin-1.</csml:comment>
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PMID: 18243041
EBP complexes with the 55-kDa protective protein-cathepsin A (PPCA) and the 61-kDa neuraminidase (Neu-1) on the cell surface.</csml:comment>
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PMID: 18243041
EBP complexes with the 55-kDa protective protein-cathepsin A (PPCA) and the 61-kDa neuraminidase (Neu-1) on the cell surface.</csml:comment>
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</csml:comment>
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<csml:comment type="text">


PMID: 18243041, 10201943, 11000131, 8941660
low molecular weight fragments of hyaluronan increase the expression of matrix metalloproteinase (MMP)-12, plasminogen activator inhibitor (PAI)-1 and stimulate the production of several cytokines, including MIP-1alpha, MIP-1beta, MCP-1, KC, IL-8, and IL-12 by macrophages.

PMID: 18243041
Initial studies indicated that signaling from hyaluronan degradation products involves CD44 exclusively.</csml:comment>
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<csml:comment type="text">

Indirect</csml:comment>
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PMID: 18243041, 10201943, 11000131, 8941660
low molecular weight fragments of hyaluronan increase the expression of matrix metalloproteinase (MMP)-12, plasminogen activator inhibitor (PAI)-1 and stimulate the production of several cytokines, including MIP-1alpha, MIP-1beta, MCP-1, KC, IL-8, and IL-12 by macrophages.</csml:comment>
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PMID: 18243041, 10201943, 11000131, 8941660
low molecular weight fragments of hyaluronan increase the expression of matrix metalloproteinase (MMP)-12, plasminogen activator inhibitor (PAI)-1 and stimulate the production of several cytokines, including MIP-1alpha, MIP-1beta, MCP-1, KC, IL-8, and IL-12 by macrophages.</csml:comment>
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PMID: 18243041, 10201943, 11000131, 8941660
low molecular weight fragments of hyaluronan increase the expression of matrix metalloproteinase (MMP)-12, plasminogen activator inhibitor (PAI)-1 and stimulate the production of several cytokines, including MIP-1alpha, MIP-1beta, MCP-1, KC, IL-8, and IL-12 by macrophages.</csml:comment>
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PMID: 18243041, 10201943, 11000131, 8941660
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PMID: 18243041, 10201943, 11000131, 8941660
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</csml:comment>
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PMID: 18243041, 10201943, 11000131, 8941660
low molecular weight fragments of hyaluronan increase the expression of matrix metalloproteinase (MMP)-12, plasminogen activator inhibitor (PAI)-1 and stimulate the production of several cytokines, including MIP-1alpha, MIP-1beta, MCP-1, KC, IL-8, and IL-12 by macrophages.</csml:comment>
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PMID: 18243041, 1740645, 7696347, 17327485
Several fibronectin-derived fragments increase monocyte/macrophage secretion of proteases (e.g., MMP-9/gelatinase B, MMP-12/macrophage elastase) and pro-inflammatory cytokines (e.g., IL-1, IL-6, and TNFalpha).

</csml:comment>
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Indirect</csml:comment>
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PMID: 18243041
In these same studies, stimulation of T cells with elastin peptides resulted in interferon gamma release that correlated with the severity of emphysema.</csml:comment>
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PMID: 18243041
In these same studies, stimulation of T cells with elastin peptides resulted in interferon gamma release that correlated with the severity of emphysema.</csml:comment>
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PMID: 18243041, 1740645, 7696347, 17327485
Several fibronectin-derived fragments increase monocyte/macrophage secretion of proteases (e.g., MMP-9/gelatinase B, MMP-12/macrophage elastase) and pro-inflammatory cytokines (e.g., IL-1, IL-6, and TNFalpha).</csml:comment>
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PMID: 18243041, 1740645, 7696347, 17327485
Several fibronectin-derived fragments increase monocyte/macrophage secretion of proteases (e.g., MMP-9/gelatinase B, MMP-12/macrophage elastase) and pro-inflammatory cytokines (e.g., IL-1, IL-6, and TNFalpha).</csml:comment>
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PMID: 18243041, 1740645, 7696347, 17327485
Several fibronectin-derived fragments increase monocyte/macrophage secretion of proteases (e.g., MMP-9/gelatinase B, MMP-12/macrophage elastase) and pro-inflammatory cytokines (e.g., IL-1, IL-6, and TNFalpha).</csml:comment>
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PMID: 18243041, 1740645, 7696347, 17327485
Several fibronectin-derived fragments increase monocyte/macrophage secretion of proteases (e.g., MMP-9/gelatinase B, MMP-12/macrophage elastase) and pro-inflammatory cytokines (e.g., IL-1, IL-6, and TNFalpha).</csml:comment>
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PMID: 18243041, 1740645, 7696347, 17327485
Several fibronectin-derived fragments increase monocyte/macrophage secretion of proteases (e.g., MMP-9/gelatinase B, MMP-12/macrophage elastase) and pro-inflammatory cytokines (e.g., IL-1, IL-6, and TNFalpha).</csml:comment>
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PMID: 18243041, 1740645, 7696347, 17327485
Several fibronectin-derived fragments increase monocyte/macrophage secretion of proteases (e.g., MMP-9/gelatinase B, MMP-12/macrophage elastase) and pro-inflammatory cytokines (e.g., IL-1, IL-6, and TNFalpha).</csml:comment>
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PMID: 18243041, 1740645, 7696347, 17327485
Several fibronectin-derived fragments increase monocyte/macrophage secretion of proteases (e.g., MMP-9/gelatinase B, MMP-12/macrophage elastase) and pro-inflammatory cytokines (e.g., IL-1, IL-6, and TNFalpha).</csml:comment>
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PMID: 18243041, 1740645, 7696347, 17327485
Several fibronectin-derived fragments increase monocyte/macrophage secretion of proteases (e.g., MMP-9/gelatinase B, MMP-12/macrophage elastase) and pro-inflammatory cytokines (e.g., IL-1, IL-6, and TNFalpha).</csml:comment>
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PMID: 18243041, 1740645, 7696347, 17327485
Several fibronectin-derived fragments increase monocyte/macrophage secretion of proteases (e.g., MMP-9/gelatinase B, MMP-12/macrophage elastase) and pro-inflammatory cytokines (e.g., IL-1, IL-6, and TNFalpha).</csml:comment>
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PMID: 18243041, 1740645, 7696347, 17327485
Several fibronectin-derived fragments increase monocyte/macrophage secretion of proteases (e.g., MMP-9/gelatinase B, MMP-12/macrophage elastase) and pro-inflammatory cytokines (e.g., IL-1, IL-6, and TNFalpha).</csml:comment>
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PMID: 18243041, 12817023, 7737965, 12817023
Peptides containing the SIKVAV sequence of laminin-111 induce the expression of MMP-9 and urokinase-type plaminogen activator (uPA) by monocytes/macrophages, and a similar peptide (ASKVKV) derived from laminin-511 induces MMP-9 and MMP-14/MT1-MMP production by monocytes and macrophages.</csml:comment>
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PMID: 18243041, 12817023, 7737965, 12817023
Peptides containing the SIKVAV sequence of laminin-111 induce the expression of MMP-9 and urokinase-type plaminogen activator (uPA) by monocytes/macrophages, and a similar peptide (ASKVKV) derived from laminin-511 induces MMP-9 and MMP-14/MT1-MMP production by monocytes and macrophages.</csml:comment>
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PMID: 18243041, 12817023, 7737965, 12817023
Peptides containing the SIKVAV sequence of laminin-111 induce the expression of MMP-9 and urokinase-type plaminogen activator (uPA) by monocytes/macrophages, and a similar peptide (ASKVKV) derived from laminin-511 induces MMP-9 and MMP-14/MT1-MMP production by monocytes and macrophages.</csml:comment>
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PMID: 18243041, 12817023, 7737965, 12817023
Peptides containing the SIKVAV sequence of laminin-111 induce the expression of MMP-9 and urokinase-type plaminogen activator (uPA) by monocytes/macrophages, and a similar peptide (ASKVKV) derived from laminin-511 induces MMP-9 and MMP-14/MT1-MMP production by monocytes and macrophages.</csml:comment>
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PMID: 18243041, 12817023, 7737965, 12817023
Peptides containing the SIKVAV sequence of laminin-111 induce the expression of MMP-9 and urokinase-type plaminogen activator (uPA) by monocytes/macrophages, and a similar peptide (ASKVKV) derived from laminin-511 induces MMP-9 and MMP-14/MT1-MMP production by monocytes and macrophages.</csml:comment>
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PMID: 18243041, 12817023, 7737965, 12817023
Peptides containing the SIKVAV sequence of laminin-111 induce the expression of MMP-9 and urokinase-type plaminogen activator (uPA) by monocytes/macrophages, and a similar peptide (ASKVKV) derived from laminin-511 induces MMP-9 and MMP-14/MT1-MMP production by monocytes and macrophages.</csml:comment>
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PMID: 18243041, 12817023, 7737965, 12817023
Peptides containing the SIKVAV sequence of laminin-111 induce the expression of MMP-9 and urokinase-type plaminogen activator (uPA) by monocytes/macrophages, and a similar peptide (ASKVKV) derived from laminin-511 induces MMP-9 and MMP-14/MT1-MMP production by monocytes and macrophages.</csml:comment>
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PMID: 18243041, 12817023, 7737965, 12817023
Peptides containing the SIKVAV sequence of laminin-111 induce the expression of MMP-9 and urokinase-type plaminogen activator (uPA) by monocytes/macrophages, and a similar peptide (ASKVKV) derived from laminin-511 induces MMP-9 and MMP-14/MT1-MMP production by monocytes and macrophages.</csml:comment>
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PMID: 18243041, 15661925
Additional studies using microarray analysis indicated that this laminin alpha5-derived peptide up-regulates many genes, including the pro-inflammatory cytokine TNFalpha and one of its receptors, TNFR-II.</csml:comment>
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PMID: 18243041, 15661925
Additional studies using microarray analysis indicated that this laminin alpha5-derived peptide up-regulates many genes, including the pro-inflammatory cytokine TNFalpha and one of its receptors, TNFR-II.</csml:comment>
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PMID: 18243041, 15860743
Using melanoma cells as the target cell and induction of IL-1beta as the readout Debret et al. found that VGVAPG induced NF-kappaB translocation and DNA binding.</csml:comment>
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