Entity
IKK-alpha
--
MO000000210
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m181
10
infinite
0
InterPro | IPR000719 |
TRANSPATH | MO000000210 |
--
--
e1
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane
--
--
--
csml-variable:Double
m1
0
infinite
0
--
--
e10
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytosol
--
--
--
csml-variable:Double
m10
0
infinite
0
--
--
e11
cso30:c:EntityBiologicalCompartment
cso30:i:CC_EndosomeMembrane
--
--
--
csml-variable:Double
m11
0
infinite
0
--
--
e12
cso30:c:EntityBiologicalCompartment
cso30:i:CC_EndosomeLumen
--
--
--
csml-variable:Double
m12
0
infinite
0
--
--
e13
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Endosome
--
--
--
csml-variable:Double
m13
0
infinite
0
--
CpG DNA: TLR9: MyD88
--
e14
cso30:c:Complex
cso30:i:CC_EndosomeMembrane
--
csml-variable:Double
m14
0
infinite
0
--
csml-variable:Double
m15
0
infinite
0
--
ssRNA: TLR7
--
e16
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m16
0
infinite
0
--
ssRNA: TLR7: MyD88
--
e17
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m17
0
infinite
0
--
Unc93b1
--
e18
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m18
0
infinite
0
--
Unc93b1 {activated}
--
e19
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m19
0
infinite
0
--
--
e2
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m2
0
infinite
0
--
csml-variable:Double
m21
0
infinite
0
--
csml-variable:Double
m22
0
infinite
0
--
cytosolic DNA: DLM-1
--
e23
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m23
0
infinite
0
--
csml-variable:Double
m24
0
infinite
0
--
IKK-alpha{active}
--
e25
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m25
10
infinite
0
InterPro | IPR000719 |
TRANSPATH | MO000000210 |
--
--
e3
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
--
csml-variable:Double
m3
0
infinite
0
--
--
e4
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m4
0
infinite
0
--
CpG DNA
--
e5
cso30:c:Dna
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m5
0
infinite
0
--
--
e50
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelopeLumen
--
--
--
csml-variable:Double
m50
0
infinite
0
--
--
e51
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearPore
--
--
--
csml-variable:Double
m51
0
infinite
0
--
--
e52
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearInnerMembrane
--
--
--
csml-variable:Double
m52
0
infinite
0
--
--
e53
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearLumen
--
--
--
csml-variable:Double
m53
0
infinite
0
--
--
e54
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearOuterMembrane
--
--
--
csml-variable:Double
m54
0
infinite
0
--
--
e55
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleus
--
--
--
csml-variable:Double
m55
0
infinite
0
--
--
e56
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleoplasm
--
--
--
csml-variable:Double
m56
0
infinite
0
--
--
e57
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearBody
--
--
--
csml-variable:Double
m57
0
infinite
0
--
--
e58
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleolus
--
--
--
csml-variable:Double
m58
0
infinite
0
--
--
e59
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelope
--
--
--
csml-variable:Double
m59
0
infinite
0
--
CpG DNA: TLR9
--
e6
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m6
0
infinite
0
--
--
e60
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Chromatin
--
--
--
csml-variable:Double
m60
0
infinite
0
--
--
e61
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearChromosome
--
--
--
csml-variable:Double
m61
0
infinite
0
--
--
e62
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearCentromere
--
--
--
csml-variable:Double
m62
0
infinite
0
--
--
e7
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell
--
--
--
csml-variable:Double
m7
0
infinite
0
--
--
e8
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell_WithoutCellWall_
--
--
--
csml-variable:Double
m8
0
infinite
0
--
--
e9
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytoplasm
--
--
--
csml-variable:Double
m9
0
infinite
0
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1
m5*m19828*0.1
nodelay
--
0
PMID: 18241699 The immune response induced by the pathogen-associated-pattern recognition receptor toll-like receptor 9 (TLR9) upon binding of CpG motif-containing DNA has been widely accepted as an important pathway in the immune defense against microbial pathogens.
p7
p10
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c27 : 1
stoichiometry:c30 : 1
stoichiometry:c28 : 1
m181*m17*0.1
nodelay
--
0
PMID: 18241699, 16415873, 16612387 It raises the question of how the endosomal ssRNA and DNA-recognizing receptors, TLR7 and TLR9 respectively, execute their different functions at the signaling level, because known signaling molecules e.g. MyD88, Unc93b1 and I¦ÊB-alpha are used by both TLRs.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1
m1572*m6*0.1
nodelay
--
0
PMID: 18241699 Upon subsequent delivery to endosomes, this DNA interacts with and stimulates TLR9, which results in signaling via MyD88 pathway.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1
m15*m19940*0.1
nodelay
--
0
PMID: 18241699, 16415873, 16612387 It raises the question of how the endosomal ssRNA and DNA-recognizing receptors, TLR7 and TLR9 respectively, execute their different functions at the signaling level, because known signaling molecules e.g. MyD88, Unc93b1 and I¦ÊB-alpha are used by both TLRs.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1
m1572*m16*0.1
nodelay
--
0
PMID: 18241699, 16415873, 16612387 It raises the question of how the endosomal ssRNA and DNA-recognizing receptors, TLR7 and TLR9 respectively, execute their different functions at the signaling level, because known signaling molecules e.g. MyD88, Unc93b1 and I¦ÊB-alpha are used by both TLRs.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c17 : 1
stoichiometry:c14 : 1
m18*m14*0.1
nodelay
--
0
PMID: 18241699, 16415873, 16612387 It raises the question of how the endosomal ssRNA and DNA-recognizing receptors, TLR7 and TLR9 respectively, execute their different functions at the signaling level, because known signaling molecules e.g. MyD88, Unc93b1 and I¦ÊB-alpha are used by both TLRs.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c18 : 1
stoichiometry:c16 : 1
m18*m17*0.1
nodelay
--
0
PMID: 18241699, 16415873, 16612387 It raises the question of how the endosomal ssRNA and DNA-recognizing receptors, TLR7 and TLR9 respectively, execute their different functions at the signaling level, because known signaling molecules e.g. MyD88, Unc93b1 and I¦ÊB-alpha are used by both TLRs.
p7
p7
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c29 : 1
stoichiometry:c20 : 1
m181*m14*0.1
nodelay
--
0
PMID: 18241699, 16415873, 16612387 It raises the question of how the endosomal ssRNA and DNA-recognizing receptors, TLR7 and TLR9 respectively, execute their different functions at the signaling level, because known signaling molecules e.g. MyD88, Unc93b1 and I¦ÊB-alpha are used by both TLRs.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c21 : 1
stoichiometry:c22 : 1
stoichiometry:c23 : 1
m22*m21*0.1
nodelay
--
0
PMID: 18241699, 11842111 One most recently identified candidate is DLM-1 (also called DAI or ZBP-1), a gene prominently expressed in lymph node and spleen, which is able to act as a positive regulator of type I IFN induction by directly binding cytosolic DNA, regardless of bacterial or mammalian origin.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c24 : 1
m24*m23*0.1
nodelay
--
0
PMID: 18241699, 11842111 One most recently identified candidate is DLM-1 (also called DAI or ZBP-1), a gene prominently expressed in lymph node and spleen, which is able to act as a positive regulator of type I IFN induction by directly binding cytosolic DNA, regardless of bacterial or mammalian origin.
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--