majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:18241699.csml convertedTime:2009.07.01.11:14

Entity

MO000000210:IKK-alpha MO000016573:MyD88 MO000016658:IFN Type I MO000042012:TLR9 MO000042126:TLR7 e1: e10: e11: e12: e13: e14:CpG DNA: TLR9: MyD88 e15:ssRNA e16:ssRNA: TLR7 e17:ssRNA: TLR7: MyD88 e18:Unc93b1 e19:Unc93b1 {activated} e2: e21:cytosolic DNA e22:DLM-1 e23:cytosolic DNA: DLM-1 e24:IFN Type I e25:IKK-alpha{active} e3: e4: e5:CpG DNA e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:CpG DNA: TLR9 e60: e61: e62: e7: e8: e9:

Process

p1 p10 p2 p3 p4 p5 p6 p7 p8 p9
600.0, 416.0
40.0, 40.0

IKK-alpha

--

MO000000210

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7 p10

true true true true

csml-variable:Double

m181

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000210

--

Go back
446.0, 315.0
33.0, 33.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2 p4

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
725.0, 766.0
36.0, 36.0

IFN Type I

--

MO000016658

cso30:c:Protein

cso30:i:CC_CellComponent

--

p9

--

true true true true

csml-variable:Double

m1634

10

false

infinite

0

unit false false false
TRANSPATHMO000016658

--

Go back
271.0, 192.0
32.0, 32.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
275.0, 264.0
32.0, 32.0

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
123.75, 91.99690800911759
856.2594311764528, 1243.2886940682085

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
141.0, 112.0
829.9775981223105, 1167.545103664102

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
274.0, 176.36040050822072
138.77021978647122, 231.67570591470195

--

e11

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false true false

--

Go back
274.0, 176.36040050822072
138.77021978647122, 231.67570591470195

--

e12

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false true false

--

Go back
274.0, 176.36040050822072
138.77021978647122, 231.67570591470195

--

e13

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false true false

--

Go back
390.875, 245.5
32.25, 45.0

CpG DNA: TLR9: MyD88

--

e14

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p2

p5 p7

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
48.5, 267.625
45.0, 24.75

ssRNA

--

e15

cso30:c:Rna

cso30:i:CC_Extracellular

--

--

p3

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
276.625, 309.5
36.75, 45.0

ssRNA: TLR7

--

e16

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p3

p4

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
346.625, 375.5
33.639018496917174, 41.1906348941843

ssRNA: TLR7: MyD88

--

e17

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
603.5, 309.125
38.6, 28.949999999999996

Unc93b1

--

e18

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p5 p6

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
603.5, 365.125
38.6, 28.949999999999996

Unc93b1 {activated}

--

e19

cso30:c:Protein

cso30:i:CC_Cytosol

--

p5 p6

--

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
123.75, 91.99690800911759
856.2594311764528, 1243.2886940682085

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
760.5, 568.125
45.0, 15.75

cytosolic DNA

--

e21

cso30:c:Dna

cso30:i:CC_Cytosol

--

--

p8

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
552.5, 570.125
45.0, 27.75

DLM-1

--

e22

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p8

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
650.5, 651.25
56.98316183348925, 24.69270346117867

cytosolic DNA: DLM-1

--

e23

cso30:c:Complex

cso30:i:CC_Cytosol

--

p8

p9

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
632.5, 896.0
45.0, 24.0

IFN Type I

--

e24

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p9

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
596.0, 488.0
40.0, 40.0

IKK-alpha{active}

--

e25

cso30:c:Protein

cso30:i:CC_CellComponent

--

p7 p10

--

true true true true

csml-variable:Double

m25

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000210

--

Go back
140.87518862352903, 109.12209663264667
822.0090539293948, 1209.0383168211513

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
172.5567875770579, 139.09117672382234
758.6458560223374, 1149.1001566387988

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
408.0, 46.5
54.38752783964365, 19.035634743875274

CpG DNA

--

e5

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p1

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
305.0, 809.0
465.6500709748862, 422.29345356567933

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
355.2936761946803, 819.0077409313898
272.27955732982184, 409.2864683429171

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
311.06992643728904, 814.6363602631969
453.51021810030846, 411.0207330392853

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
311.93705878547314, 815.503492611381
451.7759534039399, 409.2864683429171

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
305.0, 809.0
465.6500709748862, 422.29345356567933

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
305.0, 809.0
465.6500709748862, 422.29345356567933

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
311.93705878547314, 815.503492611381
451.7759534039399, 409.2864683429171

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
644.9158804881849, 982.4264696368292
29.091257918298922, 26.33524401024959

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
568.6082338479803, 1103.8249983826097
82.37757307749382, 74.57338194383664

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
305.0, 809.0
465.6500709748862, 422.29345356567933

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
357.5, 182.0
35.82119646725546, 43.862689551741376

CpG DNA: TLR9

--

e6

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p1

p2

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
414.7511016961721, 996.6637213250546
14.746453546866459, 7.100144300343119

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
414.2586758712023, 975.4894108513561
50.4736470593979, 90.85256470691624

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
435.43298634490134, 1034.5805098477247
7.878813199515761, 7.8788131995157675

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
135.0, 97.0
839.7237354966342, 1189.8668429177399

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
138.0, 118.0
805.5569854171277, 1169.6687428256696

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
146.0, 139.0
801.8791759029863, 1154.3288303559784

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
318.0, 43.0
25.0, 25.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m5*m19828*0.1

nodelay

--

true

0

false

PMID: 18241699 The immune response induced by the pathogen-associated-pattern recognition receptor toll-like receptor 9 (TLR9) upon binding of CpG motif-containing DNA has been widely accepted as an important pathway in the immune defense against microbial pathogens.

Go back
469.0, 485.0
30.0, 30.0

p7

p10

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c27 : 1
stoichiometry:c30 : 1
stoichiometry:c28 : 1

m181*m17*0.1

nodelay

--

true

0

false

PMID: 18241699, 16415873, 16612387 It raises the question of how the endosomal ssRNA and DNA-recognizing receptors, TLR7 and TLR9 respectively, execute their different functions at the signaling level, because known signaling molecules e.g. MyD88, Unc93b1 and I¦ÊB-alpha are used by both TLRs.

Go back
461.0, 254.0
27.0, 27.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m1572*m6*0.1

nodelay

--

true

0

false

PMID: 18241699 Upon subsequent delivery to endosomes, this DNA interacts with and stimulates TLR9, which results in signaling via MyD88 pathway.

Go back
201.0, 266.0
27.0, 27.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m15*m19940*0.1

nodelay

--

true

0

false

PMID: 18241699, 16415873, 16612387 It raises the question of how the endosomal ssRNA and DNA-recognizing receptors, TLR7 and TLR9 respectively, execute their different functions at the signaling level, because known signaling molecules e.g. MyD88, Unc93b1 and I¦ÊB-alpha are used by both TLRs.

Go back
390.0, 319.0
25.0, 25.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m1572*m16*0.1

nodelay

--

true

0

false

PMID: 18241699, 16415873, 16612387 It raises the question of how the endosomal ssRNA and DNA-recognizing receptors, TLR7 and TLR9 respectively, execute their different functions at the signaling level, because known signaling molecules e.g. MyD88, Unc93b1 and I¦ÊB-alpha are used by both TLRs.

Go back
536.0, 309.0
29.0, 29.0

p5

p5

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c17 : 1
stoichiometry:c14 : 1

m18*m14*0.1

nodelay

--

true

0

false

PMID: 18241699, 16415873, 16612387 It raises the question of how the endosomal ssRNA and DNA-recognizing receptors, TLR7 and TLR9 respectively, execute their different functions at the signaling level, because known signaling molecules e.g. MyD88, Unc93b1 and I¦ÊB-alpha are used by both TLRs.

Go back
536.0, 365.0
30.0, 30.0

p6

p6

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c18 : 1
stoichiometry:c16 : 1

m18*m17*0.1

nodelay

--

true

0

false

PMID: 18241699, 16415873, 16612387 It raises the question of how the endosomal ssRNA and DNA-recognizing receptors, TLR7 and TLR9 respectively, execute their different functions at the signaling level, because known signaling molecules e.g. MyD88, Unc93b1 and I¦ÊB-alpha are used by both TLRs.

Go back
489.0, 421.0
30.0, 30.0

p7

p7

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c29 : 1
stoichiometry:c20 : 1

m181*m14*0.1

nodelay

--

true

0

false

PMID: 18241699, 16415873, 16612387 It raises the question of how the endosomal ssRNA and DNA-recognizing receptors, TLR7 and TLR9 respectively, execute their different functions at the signaling level, because known signaling molecules e.g. MyD88, Unc93b1 and I¦ÊB-alpha are used by both TLRs.

Go back
665.0, 582.0
28.0, 28.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c21 : 1
stoichiometry:c22 : 1
stoichiometry:c23 : 1

m22*m21*0.1

nodelay

--

true

0

false

PMID: 18241699, 11842111 One most recently identified candidate is DLM-1 (also called DAI or ZBP-1), a gene prominently expressed in lymph node and spleen, which is able to act as a positive regulator of type I IFN induction by directly binding cytosolic DNA, regardless of bacterial or mammalian origin.

Go back
640.0, 769.0
30.0, 30.0

p9

p9

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c24 : 1

m24*m23*0.1

nodelay

--

true

0

false

PMID: 18241699, 11842111 One most recently identified candidate is DLM-1 (also called DAI or ZBP-1), a gene prominently expressed in lymph node and spleen, which is able to act as a positive regulator of type I IFN induction by directly binding cytosolic DNA, regardless of bacterial or mammalian origin.

Go back
351.0, 56.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
423.0, 332.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
313.0, 332.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
380.23999152002546, 344.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
573.0, 324.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
565.0, 335.0

c14

c14

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
572.3409919128368, 338.0

c15

c15

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
566.0, 380.0

c16

c16

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
423.0, 274.0

c17

c17

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
380.0, 381.71507491748497

c18

c18

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
527.0, 436.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
292.0, 75.68276981402899

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
519.0, 446.0

c20

c20

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
598.0, 586.0

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
700.8576953209139, 580.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
679.0, 610.0

c23

c23

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
670.0, 784.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
655.0, 807.0

c25

c25

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
659.601331299634, 676.0

c26

c26

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
506.22552674241246, 445.0

c27

c27

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
499.0, 501.0

c28

c28

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
420.0, 291.0

c29

c29

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
335.0, 68.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
380.0, 411.0

c30

c30

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
466.0, 288.8356563460532

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
393.0, 216.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
431.0, 268.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
94.0, 280.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
236.0, 280.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
228.0, 288.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back