_enti_e7
_enti_e8
_enti_e9
_enti_e1
_enti_e10
_enti_e4
_enti_e3
_enti_e2
_enti_e55
_enti_e109
_enti_e53
_enti_e59
_enti_e111
_enti_e110
_enti_e51
_enti_e52
_enti_e54
_enti_e50
_enti_e56
_enti_e61
_enti_e58
_enti_e57
_enti_e62
_enti_e60
g1_fact_g1
g1_fact_g14
g2_fact_g12
g2_fact_g13
g1_fact_g2
p1_propro_p1
PMID: 18161744
Lipopolysaccharide (LPS), which binds to TLR4, is
one of the most well-studied PAMPs.
PMID: 18161744
TLR4 requires
MD-2 to recognize the active moiety of LPS.
PMID: 18161744
MD-2
is expressed as a dimer with TLR4 on the surface
of immune cells.
c1 cso30:c:InputProcess connector
c2 cso30:c:InputProcess connector
c3 cso30:c:OutputProcess connector
p2_propro_p2
PMID: 18161744
Lipid A and its two derivatives,
monophosphoryl lipid A and lipid IVa, bind directly to
MD-2.
c4 cso30:c:InputProcess connector
c5 cso30:c:InputProcess connector
c8 cso30:c:OutputProcess connector
p3_propro_p3
PMID: 18161744,17056597,17569869
Lipid A engagement
results in activation of both MyD88-dependent
and TRIF-dependent (MyD88-independent) signalling
events, whereas monophosphoryl lipid A causes
primarily activation of TRIF-mediated signalling pathways.
PMID: 18161744,17569868
Binding of Lipid IVa to MD-2TLR4 complex
inhibits signalling events mediated by MyD88
and TRIF
c9 cso30:c:InputProcess connector
c10 cso30:c:InputProcess connector
c23 cso30:c:InputInhibitor connector
c11 cso30:c:OutputProcess connector
p3_propro_p4
PMID: 18161744,17056597,17569869
Lipid A engagement
results in activation of both MyD88-dependent
and TRIF-dependent (MyD88-independent) signalling
events, whereas monophosphoryl lipid A causes
primarily activation of TRIF-mediated signalling pathways.
c12 cso30:c:InputProcess connector
c13 cso30:c:InputProcess connector
c14 cso30:c:InputProcess connector
c15 cso30:c:OutputProcess connector
p2_propro_p5
PMID: 18161744
Lipid A and its two derivatives,
monophosphoryl lipid A and lipid IVa, bind directly to
MD-2.
c6 cso30:c:InputProcess connector
c7 cso30:c:InputProcess connector
c16 cso30:c:OutputProcess connector
p3_propro_p6
PMID: 18161744,17056597,17569869
Lipid A engagement
results in activation of both MyD88-dependent
and TRIF-dependent (MyD88-independent) signalling
events, whereas monophosphoryl lipid A causes
primarily activation of TRIF-mediated signalling pathways.
c17 cso30:c:InputProcess connector
c18 cso30:c:InputProcess connector
c19 cso30:c:OutputProcess connector
p2_propro_p7
PMID: 18161744
Lipid A and its two derivatives,
monophosphoryl lipid A and lipid IVa, bind directly to
MD-2.
c20 cso30:c:InputProcess connector
c21 cso30:c:InputProcess connector
c22 cso30:c:OutputProcess connector
p8_propro_p8
PMID: 18161744
NOD1 is encoded
by the caspase-recruitment domain 4 (CARD4) gene,
whereas NOD2 is encoded by the caspase-recruitment
domain 15 (CARD15) gene.
c24 cso30:c:InputAssociation connector
c25 cso30:c:OutputProcess connector
p9_propro_p9
PMID: 18161744
NOD1 is encoded
by the caspase-recruitment domain 4 (CARD4) gene,
whereas NOD2 is encoded by the caspase-recruitment
domain 15 (CARD15) gene.
c26 cso30:c:InputAssociation connector
c27 cso30:c:OutputProcess connector
p8_propro_p10
PMID: 18161744
NOD1 is encoded
by the caspase-recruitment domain 4 (CARD4) gene,
whereas NOD2 is encoded by the caspase-recruitment
domain 15 (CARD15) gene.
c28 cso30:c:InputAssociation connector
c29 cso30:c:OutputProcess connector
p9_propro_p11
PMID: 18161744
NOD1 is encoded
by the caspase-recruitment domain 4 (CARD4) gene,
whereas NOD2 is encoded by the caspase-recruitment
domain 15 (CARD15) gene.
c31 cso30:c:InputAssociation connector
c30 cso30:c:OutputProcess connector
p12_propro_p12
PMID: 18161744
Thus, NOD2
functions as a general sensor of most, if not all, bacteria,
whereas NOD1 senses primarily products yielded
from Gram-positive bacteria.
c32 cso30:c:InputProcess connector
c33 cso30:c:InputProcess connector
c34 cso30:c:OutputProcess connector
p12_propro_p13
PMID: 18161744
Thus, NOD2
functions as a general sensor of most, if not all, bacteria,
whereas NOD1 senses primarily products yielded
from Gram-positive bacteria.
c35 cso30:c:InputProcess connector
c36 cso30:c:InputProcess connector
c37 cso30:c:OutputProcess connector
p14_propro_p14
PMID: 18161744
Upon oligomerization of NOD1 or NOD2, the
recruitment of the serine/threonine kinase receptorinteracting
serine/threonine kinase (RICK; also known
as RIP2 or CARDIAK) occurs through a homophilic
CARDCARD interaction.
c38 cso30:c:InputProcess connector
c39 cso30:c:OutputProcess connector
p14_propro_p15
PMID: 18161744
Upon oligomerization of NOD1 or NOD2, the
recruitment of the serine/threonine kinase receptorinteracting
serine/threonine kinase (RICK; also known
as RIP2 or CARDIAK) occurs through a homophilic
CARDCARD interaction.
c40 cso30:c:InputProcess connector
c41 cso30:c:OutputProcess connector
p16_propro_p16
PMID: 18161744
Upon oligomerization of NOD1 or NOD2, the
recruitment of the serine/threonine kinase receptorinteracting
serine/threonine kinase (RICK; also known
as RIP2 or CARDIAK) occurs through a homophilic
CARDCARD interaction.
c42 cso30:c:InputProcess connector
c43 cso30:c:InputProcess connector
c44 cso30:c:OutputProcess connector
p16_propro_p17
PMID: 18161744
Upon oligomerization of NOD1 or NOD2, the
recruitment of the serine/threonine kinase receptorinteracting
serine/threonine kinase (RICK; also known
as RIP2 or CARDIAK) occurs through a homophilic
CARDCARD interaction.
c45 cso30:c:InputProcess connector
c46 cso30:c:InputProcess connector
c47 cso30:c:OutputProcess connector
p18_propro_p18
PMID: 18161744,15620648
Instead, upon activation by NOD2, RICK induces
K63-linked polyubiquitylation of IKKgamma /NEMO at a
unique ubiquitylation site (Lysine-285)
c48 cso30:c:InputAssociation connector
c49 cso30:c:InputProcess connector
c50 cso30:c:OutputProcess connector
p19_propro_p19
PMID: 18161744,14695475
It has
been known that K63-linked polyubiquitylation is
associated with activation of the NF-KappaB pathway
c51 cso30:c:InputAssociation connector
c52 cso30:c:InputProcess connector
c53 cso30:c:OutputProcess connector
p20_propro_p20
PMID: 18161744
The interaction of RICK and IKKgamma /NEMO
leads to translocation of NF-KappaB transcription factors
to the nucleus.
c54 cso30:c:InputProcess connector
c55 cso30:c:OutputProcess connector
p21_propro_p21
PMID: 18161744,15692051
In
addition to RICK, gene associated with retinoid-IFNinduced
mortality 19 (GRIM19) is another intracellular
molecule that has been associated with optimal NF-KappaB
activation induced by NOD2 but not NOD1
c56 cso30:c:InputAssociation connector
c57 cso30:c:InputAssociation connector
c58 cso30:c:InputProcess connector
c59 cso30:c:OutputProcess connector
p22_propro_p22
PMID: 18161744
For
example, PGN is a ligand for cell surface TLR2,
but upon uptake by macrophages, PGN can be processed
to yield MDP, a ligand for cytosolic NOD2.
c60 cso30:c:InputProcess connector
c61 cso30:c:InputProcess connector
c62 cso30:c:OutputProcess connector
p23_propro_p23
PMID: 18161744,17038590,17038589
RIG-1, but not MDA5, can recognize uncapped 5prime2;-
triphosphate RNA (termed 3pRNA) present in viruses
that can only be generated by viral polymerases, while
MDA5 is the principle cytoplasmic receptor for synthetic
poly(I : C)
c63 cso30:c:InputProcess connector
c64 cso30:c:InputProcess connector
c65 cso30:c:OutputProcess connector
p23_propro_p24
PMID: 18161744,17038590,17038589
RIG-1, but not MDA5, can recognize uncapped 5prime2;-
triphosphate RNA (termed 3pRNA) present in viruses
that can only be generated by viral polymerases, while
MDA5 is the principle cytoplasmic receptor for synthetic
poly(I : C)
c66 cso30:c:InputProcess connector
c67 cso30:c:InputProcess connector
c68 cso30:c:OutputProcess connector
p25_propro_p25
PMID: 18161744
Viral RNAs also activate
2prime,5prime-oligoadenylate synthetase (OAS) to synthesize 2prime2;,5prime2;-linked oligoadenylate (2-5A) from ATP.
c69 cso30:c:InputAssociation connector
c70 cso30:c:InputProcess connector
c71 cso30:c:OutputProcess connector
p26_propro_p26
PMID: 18161744
Viral RNAs also activate
2prime,5prime-oligoadenylate synthetase (OAS) to synthesize 2prime2;,5prime2;-linked oligoadenylate (2-5A) from ATP.
c72 cso30:c:InputProcess connector
c73 cso30:c:InputAssociation connector
c74 cso30:c:OutputProcess connector
p27_propro_p27
PMID:18161744
2-5A activates RNase L to
cleavage cellular RNAs to yield small self-RNA molecules, which are also recognized by RIG-I and/or MDA5.
c75 cso30:c:InputAssociation connector
c76 cso30:c:InputProcess connector
c77 cso30:c:OutputProcess connector
p28_propro_p28
MID:18161744
2-5A activates RNase L to
cleavage cellular RNAs to yield small self-RNA molecules, which are also recognized by RIG-I and/or MDA5.
c78 cso30:c:InputAssociation connector
c79 cso30:c:InputProcess connector
c80 cso30:c:OutputProcess connector
p29_propro_p29
MID:18161744
2-5A activates RNase L to
cleavage cellular RNAs to yield small self-RNA molecules, which are also recognized by RIG-I and/or MDA5.
c81 cso30:c:InputProcess connector
c82 cso30:c:InputProcess connector
c83 cso30:c:OutputProcess connector
p29_propro_p30
MID:18161744
2-5A activates RNase L to
cleavage cellular RNAs to yield small self-RNA molecules, which are also recognized by RIG-I and/or MDA5.
c84 cso30:c:InputProcess connector
c85 cso30:c:InputProcess connector
c86 cso30:c:OutputProcess connector
p31_propro_p31
PMID: 18161744, 16713980
The adaptor protein for RIG-1 and MDA5 is
named MAVS (VISA, CARDIF or IPS-1)
PMID: 18161744
MAVS is recruited and bound to RIG-1
or MDA5 via CARDCARD interactions.
c87 cso30:c:InputProcess connector
c88 cso30:c:InputProcess connector
c89 cso30:c:OutputProcess connector
p31_propro_p32
PMID: 18161744, 16713980
The adaptor protein for RIG-1 and MDA5 is
named MAVS (VISA, CARDIF or IPS-1)
PMID: 18161744
MAVS is recruited and bound to RIG-1
or MDA5 via CARDCARD interactions.
c90 cso30:c:InputProcess connector
c91 cso30:c:InputProcess connector
c92 cso30:c:OutputProcess connector
p33_propro_p33
c93 cso30:c:InputAssociation connector
c94 cso30:c:InputProcess connector
c95 cso30:c:OutputProcess connector
p33_propro_p34
c96 cso30:c:InputProcess connector
c97 cso30:c:InputAssociation connector
c98 cso30:c:OutputProcess connector
p35_propro_p35
PMID: 18161744
Figure 1
c100 cso30:c:InputProcess connector
c99 cso30:c:InputAssociation connector
c101 cso30:c:OutputProcess connector
c102 cso30:c:OutputProcess connector
p36_propro_p36
PMID: 18161744
Figure 1
c103 cso30:c:InputProcess connector
c104 cso30:c:OutputProcess connector
p37_propro_p37
PMID: 18161744
These events relay the signal through activation and translocation of NF-KappaB p65p50 heterodimer and IRF3 as well
as IRF7 into the nucleus to activate downstream genes that encode alpha- and beta-interferon.
c105 cso30:c:InputAssociation connector
c106 cso30:c:OutputProcess connector
p37_propro_p38
PMID: 18161744
These events relay the signal through activation and translocation of NF-KappaB p65p50 heterodimer and IRF3 as well
as IRF7 into the nucleus to activate downstream genes that encode alpha- and beta-interferon.
c107 cso30:c:InputAssociation connector
c108 cso30:c:OutputProcess connector
p33_propro_p39
c109 cso30:c:InputAssociation connector
c110 cso30:c:InputProcess connector
c111 cso30:c:OutputProcess connector
p40_propro_p40
PMID: 18161744
TRAF3
has been shown to interact with MAVS, and be essential
for MAVS-mediated IFNalpha production and antiviral
responses.
c112 cso30:c:InputProcess connector
c113 cso30:c:InputProcess connector
c114 cso30:c:OutputProcess connector
p40_propro_p41
PMID: 18161744
TRAF3
has been shown to interact with MAVS, and be essential
for MAVS-mediated IFNalpha production and antiviral
responses.
c115 cso30:c:InputProcess connector
c116 cso30:c:InputProcess connector
c117 cso30:c:OutputProcess connector
p42_propro_p42
PMID: 18161744
Figure 1
c118 cso30:c:InputAssociation connector
c119 cso30:c:InputProcess connector
c120 cso30:c:OutputProcess connector
p42_propro_p43
PMID: 18161744
Figure 1
c121 cso30:c:InputAssociation connector
c122 cso30:c:InputProcess connector
c123 cso30:c:OutputProcess connector
p42_propro_p44
PMID: 18161744
Figure 1
c124 cso30:c:InputAssociation connector
c125 cso30:c:InputProcess connector
c126 cso30:c:OutputProcess connector
p45_propro_p45
PMID: 18161744
Figure 1
c127 cso30:c:InputProcess connector
c131 cso30:c:OutputProcess connector
p45_propro_p46
PMID: 18161744
Figure 1
c128 cso30:c:InputProcess connector
c133 cso30:c:OutputProcess connector
p47_propro_p47
c129 cso30:c:InputProcess connector
c130 cso30:c:InputProcess connector
c132 cso30:c:OutputProcess connector
p48_propro_p48
PMID: 18161744
Figure 1
c134 cso30:c:InputProcess connector
c135 cso30:c:OutputProcess connector
p48_propro_p49
PMID: 18161744
Figure 1
c136 cso30:c:InputProcess connector
c137 cso30:c:OutputProcess connector
p48_propro_p50
PMID: 18161744
Figure 1
c138 cso30:c:InputProcess connector
c139 cso30:c:OutputProcess connector
p37_propro_p51
PMID: 18161744
These events relay the signal through activation and translocation of NF-KappaB p65p50 heterodimer and IRF3 as well
as IRF7 into the nucleus to activate downstream genes that encode alpha- and beta-interferon.
c140 cso30:c:InputAssociation connector
c141 cso30:c:OutputProcess connector
p37_propro_p52
PMID: 18161744
These events relay the signal through activation and translocation of NF-KappaB p65p50 heterodimer and IRF3 as well
as IRF7 into the nucleus to activate downstream genes that encode alpha- and beta-interferon.
c142 cso30:c:InputAssociation connector
c143 cso30:c:OutputProcess connector
p37_propro_p53
PMID: 18161744
These events relay the signal through activation and translocation of NF-KappaB p65p50 heterodimer and IRF3 as well
as IRF7 into the nucleus to activate downstream genes that encode alpha- and beta-interferon.
c144 cso30:c:InputAssociation connector
c145 cso30:c:OutputProcess connector
p37_propro_p54
PMID: 18161744
These events relay the signal through activation and translocation of NF-KappaB p65p50 heterodimer and IRF3 as well
as IRF7 into the nucleus to activate downstream genes that encode alpha- and beta-interferon.
c146 cso30:c:InputAssociation connector
c147 cso30:c:OutputProcess connector
p37_propro_p55
PMID: 18161744
These events relay the signal through activation and translocation of NF-KappaB p65p50 heterodimer and IRF3 as well
as IRF7 into the nucleus to activate downstream genes that encode alpha- and beta-interferon.
c148 cso30:c:InputAssociation connector
c149 cso30:c:OutputProcess connector
p37_propro_p56
PMID: 18161744
These events relay the signal through activation and translocation of NF-KappaB p65p50 heterodimer and IRF3 as well
as IRF7 into the nucleus to activate downstream genes that encode alpha- and beta-interferon.
c150 cso30:c:InputAssociation connector
c151 cso30:c:OutputProcess connector
p57_propro_p57
PMID: 18161744,10623794
In
macrophages, HSP60 induces the production of NO
and TNFalpha via TLR4
c152 cso30:c:InputProcess connector
c153 cso30:c:InputProcess connector
c154 cso30:c:OutputProcess connector
p58_propro_p58
c155 cso30:c:InputAssociation connector
c156 cso30:c:OutputProcess connector
p59_propro_p59
PMID: 18161744,10623794
In
macrophages, HSP60 induces the production of NO
and TNFalpha via TLR4
PMID: 18161744,17321471,16339566
Treatment
of macrophages with an agonist of the adenosine
A2A receptor (A2AR) inhibits TNF production, whereas agonists of A2BR increase IL-10 production
by a post-translational mechanism
c157 cso30:c:InputAssociation connector
c159 cso30:c:InputAssociation connector
c327 cso30:c:InputInhibitor connector
c158 cso30:c:OutputProcess connector
p60_propro_p60
PMID: 18161744,11842086
TLR4 is also critical for
HSP70 induction of IL-12 production
c160 cso30:c:InputProcess connector
c161 cso30:c:InputProcess connector
c162 cso30:c:OutputProcess connector
p61_propro_p61
c163 cso30:c:InputAssociation connector
c164 cso30:c:InputAssociation connector
c165 cso30:c:OutputProcess connector
p62_propro_p62
PMID: 18161744,11912201
Gp96-
induced production of pro-inflammatory cytokines
and other co-stimulation factors from bone marrowderived
DCs is also dependent on TLR4 but it may
also involve TLR2
c166 cso30:c:InputProcess connector
c167 cso30:c:InputProcess connector
c168 cso30:c:OutputProcess connector
p62_propro_p63
PMID: 18161744,11912201
Gp96-
induced production of pro-inflammatory cytokines
and other co-stimulation factors from bone marrowderived
DCs is also dependent on TLR4 but it may
also involve TLR2
c169 cso30:c:InputProcess connector
c170 cso30:c:InputProcess connector
c171 cso30:c:OutputProcess connector
p64_propro_p64
PMID: 18161744,11912201
Gp96-
induced production of pro-inflammatory cytokines
and other co-stimulation factors from bone marrowderived
DCs is also dependent on TLR4 but it may
also involve TLR2
PMID: 18161744,12401407
These monocytes express high levels
of formyl-peptide receptor 1 (FPR1), which, when ligated,
suppresses the production of pro-inflammatory
cytokines and removes damaged cells
c172 cso30:c:InputAssociation connector
c174 cso30:c:InputAssociation connector
c345 cso30:c:InputInhibitor connector
c173 cso30:c:OutputProcess connector
p64_propro_p65
PMID: 18161744,11912201
Gp96-
induced production of pro-inflammatory cytokines
and other co-stimulation factors from bone marrowderived
DCs is also dependent on TLR4 but it may
also involve TLR2
PMID: 18161744,12401407
These monocytes express high levels
of formyl-peptide receptor 1 (FPR1), which, when ligated,
suppresses the production of pro-inflammatory
cytokines and removes damaged cells
c175 cso30:c:InputAssociation connector
c176 cso30:c:InputAssociation connector
c346 cso30:c:InputInhibitor connector
c177 cso30:c:OutputProcess connector
p64_propro_p66
PMID: 18161744,11912201
Gp96-
induced production of pro-inflammatory cytokines
and other co-stimulation factors from bone marrowderived
DCs is also dependent on TLR4 but it may
also involve TLR2
c178 cso30:c:InputAssociation connector
c180 cso30:c:InputAssociation connector
c179 cso30:c:OutputProcess connector
p64_propro_p67
PMID: 18161744,11912201
Gp96-
induced production of pro-inflammatory cytokines
and other co-stimulation factors from bone marrowderived
DCs is also dependent on TLR4 but it may
also involve TLR2
c181 cso30:c:InputAssociation connector
c183 cso30:c:InputAssociation connector
c182 cso30:c:OutputProcess connector
p68_propro_p68
PMID: 18161744
CD44 is the major
cell surface receptor for hyaluronan, but recent evidence
indicates that hyaluronan can also bind to
and signal through TLR2 and TLR4.
c184 cso30:c:InputProcess connector
c185 cso30:c:OutputProcess connector
c186 cso30:c:OutputProcess connector
p68_propro_p69
PMID: 18161744
CD44 is the major
cell surface receptor for hyaluronan, but recent evidence
indicates that hyaluronan can also bind to
and signal through TLR2 and TLR4.
c187 cso30:c:InputProcess connector
c188 cso30:c:InputProcess connector
c189 cso30:c:OutputProcess connector
p68_propro_p70
PMID: 18161744
CD44 is the major
cell surface receptor for hyaluronan, but recent evidence
indicates that hyaluronan can also bind to
and signal through TLR2 and TLR4.
c190 cso30:c:InputProcess connector
c191 cso30:c:InputProcess connector
c192 cso30:c:OutputProcess connector
p71_propro_p71
PMID: 18161744
During tissue injury and/or
inflammation, however, hyaluronan is progressively
cleaved by a series of enzymatic reactions that yield
hyaluronic acids of smaller sizes.
c193 cso30:c:InputProcess connector
c194 cso30:c:OutputProcess connector
p72_propro_p72
PMID: 18161744,16025156
Biglycan acts on macrophages to
produce TNFalpha and MIP-2 in a TLR2- and TLR4-
dependent manner
PMID: 18161744,17321471,16339566
Treatment
of macrophages with an agonist of the adenosine
A2A receptor (A2AR) inhibits TNF production, whereas agonists of A2BR increase IL-10 production
by a post-translational mechanism
c195 cso30:c:InputAssociation connector
c197 cso30:c:InputAssociation connector
c199 cso30:c:InputAssociation connector
c329 cso30:c:InputInhibitor connector
c196 cso30:c:OutputProcess connector
p72_propro_p73
PMID: 18161744,16025156
Biglycan acts on macrophages to
produce TNFalpha and MIP-2 in a TLR2- and TLR4-
dependent manner
PMID: 18161744,17321471,16339566
Treatment
of macrophages with an agonist of the adenosine
A2A receptor (A2AR) inhibits TNF production, whereas agonists of A2BR increase IL-10 production
by a post-translational mechanism
c198 cso30:c:InputAssociation connector
c200 cso30:c:InputAssociation connector
c202 cso30:c:InputAssociation connector
c328 cso30:c:InputInhibitor connector
c201 cso30:c:OutputProcess connector
p74_propro_p74
PMID: 18161744
These proteins bind to the minor groove
of DNA with little sequence specificity and regulate
many transcriptional events, primarily by increasing
the binding affinity of transcription factors to their
corresponding DNA binding sites via bending or
distortion of the double helix.
c203 cso30:c:InputProcess connector
c204 cso30:c:InputProcess connector
c205 cso30:c:InputProcess connector
p75_propro_p75
PMID: 18161744,16267105
In fact FNEDA,
as an endogenous ligand for TLR4, has been
investigated as a potential adjuvant
c206 cso30:c:InputProcess connector
c244 cso30:c:InputProcess connector
c208 cso30:c:OutputProcess connector
p76_propro_p76
PMID: 18161744,10521347
Beta-Defensins interact with
CCR6 on the cell surface of both dendritic and T cells
to bridge innate and adaptive immunity
c209 cso30:c:InputProcess connector
c210 cso30:c:InputProcess connector
c211 cso30:c:OutputProcess connector
p77_propro_p77
PMID: 18161744,16513653
For example, human Beta-defensin 2
expression is dependent on NOD1, whereas Beta-defensin
3 expression is NOD1-independent but dependent on
EGFR and the ERK pathway
c212 cso30:c:InputAssociation connector
c213 cso30:c:OutputProcess connector
p77_propro_p78
PMID: 18161744,16513653
For example, human Beta-defensin 2
expression is dependent on NOD1, whereas Beta-defensin
3 expression is NOD1-independent but dependent on
EGFR and the ERK pathway
c214 cso30:c:InputAssociation connector
c215 cso30:c:OutputProcess connector
p77_propro_p79
PMID: 18161744,16513653
For example, human Beta-defensin 2
expression is dependent on NOD1, whereas Beta-defensin
3 expression is NOD1-independent but dependent on
EGFR and the ERK pathway
c217 cso30:c:InputAssociation connector
c216 cso30:c:OutputProcess connector
p80_propro_p80
PMID: 18161744,16473764
The receptors for Ox-LDL are
in the scavenger receptor family, and include CD36
and a newly described family member termed lectinlike
oxidized lipoprotein scavenger receptor (LOX-
1)
c218 cso30:c:InputProcess connector
c219 cso30:c:InputProcess connector
c250 cso30:c:OutputProcess connector
p81_propro_p81
PMID: 18161744,16244651
Hyaluronan fragments isolated
from individuals with acute lung injuries can activate
macrophages to produce chemokines in a TLR2- and
TLR4-dependent fashion
c220 cso30:c:InputAssociation connector
c222 cso30:c:InputAssociation connector
c221 cso30:c:OutputProcess connector
p81_propro_p82
PMID: 18161744,16244651
Hyaluronan fragments isolated
from individuals with acute lung injuries can activate
macrophages to produce chemokines in a TLR2- and
TLR4-dependent fashion
c223 cso30:c:InputAssociation connector
c225 cso30:c:InputAssociation connector
c224 cso30:c:OutputProcess connector
p83_propro_p83
PMID: 18161744,16267105
HMGB1 may either signal through multiple receptors
or associate with multiple ligands to signal through
different receptors. TLR4, TLR2 and TLR9 have
all been reported to respond to HMGB1
c226 cso30:c:InputProcess connector
c227 cso30:c:InputProcess connector
c228 cso30:c:OutputProcess connector
p83_propro_p84
PMID: 18161744,16267105
HMGB1 may either signal through multiple receptors
or associate with multiple ligands to signal through
different receptors. TLR4, TLR2 and TLR9 have
all been reported to respond to HMGB1
c229 cso30:c:InputProcess connector
c230 cso30:c:InputProcess connector
c231 cso30:c:OutputProcess connector
p83_propro_p85
PMID: 18161744,16267105
HMGB1 may either signal through multiple receptors
or associate with multiple ligands to signal through
different receptors. TLR4, TLR2 and TLR9 have
all been reported to respond to HMGB1
c232 cso30:c:InputProcess connector
c233 cso30:c:InputProcess connector
c234 cso30:c:OutputProcess connector
p86_propro_p86
PMID: 18161744,15978523
The immunoglobulin ‘superfamily’ member RAGE has
also been reported to be a receptor for HMGB1
c235 cso30:c:InputProcess connector
c236 cso30:c:InputProcess connector
c237 cso30:c:OutputProcess connector
p87_propro_p87
PMID: 18161744
Recently, Coyle and colleagues showed that class A
CpG-containing oligodeoxynucleotides (ODNs) and
HMGB1 can form a complex.
c238 cso30:c:InputProcess connector
c239 cso30:c:InputProcess connector
c240 cso30:c:OutputProcess connector
p88_propro_p88
PMID: 18161744
The resultant complex
induced association of TLR9 and RAGE to activate
plasmacytoid DCs to produce IFNalpha
c241 cso30:c:InputProcess connector
c242 cso30:c:InputProcess connector
c243 cso30:c:OutputProcess connector
p89_propro_p89
PMID: 18161744
Recombinant
Fn-EDA, but not other domains of fibronectin,
was demonstrated to induce MMP-9 expression from
human macrophages via TLR4.
c245 cso30:c:InputAssociation connector
c246 cso30:c:InputAssociation connector
c207 cso30:c:OutputProcess connector
p90_propro_p90
PMID: 18161744
Fn-
EDA also activates NF-KappaB in macrophages.
c247 cso30:c:InputAssociation connector
c248 cso30:c:InputProcess connector
c249 cso30:c:OutputProcess connector
p80_propro_p91
PMID: 18161744,16473764
The receptors for Ox-LDL are
in the scavenger receptor family, and include CD36
and a newly described family member termed lectinlike
oxidized lipoprotein scavenger receptor (LOX-
1)
c251 cso30:c:InputProcess connector
c252 cso30:c:InputProcess connector
c253 cso30:c:OutputProcess connector
p92_propro_p92
PMID: 18161744
Extracellular ATP appears to be required
for LPS-induced production of IL-1beta and IL-18 from
macrophages.
c254 cso30:c:InputAssociation connector
c256 cso30:c:InputAssociation connector
c257 cso30:c:InputAssociation connector
c255 cso30:c:OutputProcess connector
p92_propro_p93
PMID: 18161744
Extracellular ATP appears to be required
for LPS-induced production of IL-1beta and IL-18 from
macrophages.
c258 cso30:c:InputAssociation connector
c260 cso30:c:InputAssociation connector
c261 cso30:c:InputAssociation connector
c259 cso30:c:OutputProcess connector
p94_propro_p94
PMID: 18161744
It has been reported that NALP3 gene expression
in primary human monocytes is induced by
TNFα and TLR ligands.
c263 cso30:c:InputAssociation connector
c262 cso30:c:OutputProcess connector
p94_propro_p95
PMID: 18161744
It has been reported that NALP3 gene expression
in primary human monocytes is induced by
TNFα and TLR ligands.
c264 cso30:c:InputAssociation connector
c265 cso30:c:OutputProcess connector
p96_propro_p96
PMID: 18161744,16407890
In addition to ATP, other
molecules have the potential to interact with NALP3,
including nigericin, maitotoxin, Staphylococcus aureus
and Listeria monocytogenes, and RNA released from
dying cells
c266 cso30:c:InputProcess connector
c267 cso30:c:InputProcess connector
c268 cso30:c:OutputProcess connector
p96_propro_p97
PMID: 18161744,16407890
In addition to ATP, other
molecules have the potential to interact with NALP3,
including nigericin, maitotoxin, Staphylococcus aureus
and Listeria monocytogenes, and RNA released from
dying cells
c269 cso30:c:InputProcess connector
c270 cso30:c:InputProcess connector
c271 cso30:c:OutputProcess connector
p96_propro_p98
PMID: 18161744,16407890
In addition to ATP, other
molecules have the potential to interact with NALP3,
including nigericin, maitotoxin, Staphylococcus aureus
and Listeria monocytogenes, and RNA released from
dying cells
c272 cso30:c:InputProcess connector
c273 cso30:c:InputProcess connector
c274 cso30:c:OutputProcess connector
p96_propro_p99
PMID: 18161744,16407890
In addition to ATP, other
molecules have the potential to interact with NALP3,
including nigericin, maitotoxin, Staphylococcus aureus
and Listeria monocytogenes, and RNA released from
dying cells
c275 cso30:c:InputProcess connector
c276 cso30:c:InputProcess connector
c277 cso30:c:OutputProcess connector
p100_propro_p100
PMID: 18161744
Upon interaction with its ligands,
NALP3 recruits ASC via PYDPYD interactions, and
CARDINAL via NACHTFIIND interactions, respectively.
c278 cso30:c:InputProcess connector
c279 cso30:c:InputProcess connector
c280 cso30:c:InputProcess connector
c281 cso30:c:OutputProcess connector
p101_propro_p101
PMID: 18161744
By interaction with ASC, NALP3 triggers the
activation of caspase-1 and subsequent release of the
proinflammatory cytokines IL-1beta and IL-18.
c282 cso30:c:InputAssociation connector
c283 cso30:c:InputProcess connector
c284 cso30:c:OutputProcess connector
p102_propro_p102
PMID: 18161744
By interaction with ASC, NALP3 triggers the
activation of caspase-1 and subsequent release of the
proinflammatory cytokines IL-1beta and IL-18
c285 cso30:c:InputAssociation connector
c286 cso30:c:InputAssociation connector
c287 cso30:c:OutputProcess connector
p102_propro_p103
PMID: 18161744
By interaction with ASC, NALP3 triggers the
activation of caspase-1 and subsequent release of the
proinflammatory cytokines IL-1beta and IL-18
c288 cso30:c:InputAssociation connector
c289 cso30:c:InputAssociation connector
c290 cso30:c:OutputProcess connector
p104_propro_p104
PMID: 18161744,17767165
Recently,
Vogl et al demonstrated a pivotal role of these proteins
in enhancing LPS-induced phagocyte activation
via their interaction with TLR4 in models of LPSinduced
shock and Escherichia coli-induced abdominal
sepsis
c291 cso30:c:InputProcess connector
c292 cso30:c:InputProcess connector
c293 cso30:c:OutputProcess connector
p104_propro_p105
PMID: 18161744,17767165
Recently,
Vogl et al demonstrated a pivotal role of these proteins
in enhancing LPS-induced phagocyte activation
via their interaction with TLR4 in models of LPSinduced
shock and Escherichia coli-induced abdominal
sepsis
c294 cso30:c:InputProcess connector
c295 cso30:c:InputProcess connector
c296 cso30:c:OutputProcess connector
p106_propro_p106
PMID: 18161744
Mrp8 specifically interacts with the
TLR4MD2 complex to induce intracellular translocation
of MyD88 and activation of IRAK-1 and NF-κB,
leading to transcriptional up-regulation of TNF gene
expression.
c297 cso30:c:InputProcess connector
c299 cso30:c:InputAssociation connector
c298 cso30:c:OutputProcess connector
p107_propro_p107
PMID: 18161744
Mrp8 specifically interacts with the
TLR4MD2 complex to induce intracellular translocation
of MyD88 and activation of IRAK-1 and NF-κB,
leading to transcriptional up-regulation of TNF gene
expression.
c300 cso30:c:InputProcess connector
c301 cso30:c:InputAssociation connector
c302 cso30:c:OutputProcess connector
p107_propro_p108
PMID: 18161744
Mrp8 specifically interacts with the
TLR4MD2 complex to induce intracellular translocation
of MyD88 and activation of IRAK-1 and NF-κB,
leading to transcriptional up-regulation of TNF gene
expression.
c303 cso30:c:InputAssociation connector
c304 cso30:c:InputProcess connector
c305 cso30:c:OutputProcess connector
p109_propro_p109
PMID: 18161744
Mrp8 specifically interacts with the
TLR4MD2 complex to induce intracellular translocation
of MyD88 and activation of IRAK-1 and NF-κB,
leading to transcriptional up-regulation of TNF gene
expression.
c306 cso30:c:InputAssociation connector
c307 cso30:c:OutputProcess connector
p110_propro_p110
PMID: 18161744,16606666
IL-10 not only
subverts the development of classical macrophage activation
responses but also stimulates macrophages to
express B7-H4, a novel member of the B7 family of T
cell co-stimulator molecules
c308 cso30:c:InputAssociation connector
c309 cso30:c:OutputProcess connector
p111_propro_p111
PMID: 18161744
RegIIIgamma can bind to a carbohydrate component
of PGN to kill the bacteria.
c310 cso30:c:InputProcess connector
c311 cso30:c:InputProcess connector
c312 cso30:c:OutputProcess connector
p112_propro_p112
PMID: 18161744
The metabolism of the C20 fatty acid eicosapentaenoic
acid by COX2 can result in the formation of so-called resolvins, which were named because
of their ability to contribute to the resolution of
inflammation.
c313 cso30:c:InputAssociation connector
c314 cso30:c:InputProcess connector
c315 cso30:c:OutputProcess connector
p113_propro_p113
PMID: 18161744
It can also be generated
locally from extracellular ATP by the ectoenzymes
ATPaseADPase/5prime nucleotidase system expressed
on leukocytes and endothelial cells
c317 cso30:c:InputAssociation connector
c316 cso30:c:OutputProcess connector
p114_propro_p114
PMID: 18161744,17321471,16339566
Treatment
of macrophages with an agonist of the adenosine
A2A receptor (A2AR) inhibits TNF production, whereas agonists of A2BR increase IL-10 production
by a post-translational mechanism
c318 cso30:c:InputProcess connector
c319 cso30:c:InputProcess connector
c320 cso30:c:OutputProcess connector
p114_propro_p115
PMID: 18161744,17321471,16339566
Treatment
of macrophages with an agonist of the adenosine
A2A receptor (A2AR) inhibits TNF production, whereas agonists of A2BR increase IL-10 production
by a post-translational mechanism
c321 cso30:c:InputProcess connector
c322 cso30:c:InputProcess connector
c323 cso30:c:OutputProcess connector
p114_propro_p116
PMID: 18161744,17321471,16339566
Treatment
of macrophages with an agonist of the adenosine
A2A receptor (A2AR) inhibits TNF production, whereas agonists of A2BR increase IL-10 production
by a post-translational mechanism
c324 cso30:c:InputProcess connector
c325 cso30:c:InputProcess connector
c326 cso30:c:OutputProcess connector
p114_propro_p117
PMID: 18161744,17321471,16339566
Treatment
of macrophages with an agonist of the adenosine
A2A receptor (A2AR) inhibits TNF production, whereas agonists of A2BR increase IL-10 production
by a post-translational mechanism
c330 cso30:c:InputProcess connector
c331 cso30:c:InputProcess connector
c332 cso30:c:OutputProcess connector
p118_propro_p118
PMID: 18161744,17321471,16339566
Treatment
of macrophages with an agonist of the adenosine
A2A receptor (A2AR) inhibits TNF production, whereas agonists of A2BR increase IL-10 production
by a post-translational mechanism
c333 cso30:c:InputAssociation connector
c335 cso30:c:InputAssociation connector
c334 cso30:c:OutputProcess connector
p119_propro_p119
PMID: 18161744,17065555
Furthermore,
the co-stimulation of macrophages with agonists of
TLRs and A2AR results in an increase in VEGF
production by macrophages
c336 cso30:c:InputAssociation connector
c338 cso30:c:InputAssociation connector
c337 cso30:c:OutputProcess connector
p119_propro_p120
PMID: 18161744,17065555
Furthermore,
the co-stimulation of macrophages with agonists of
TLRs and A2AR results in an increase in VEGF
production by macrophages
c339 cso30:c:InputAssociation connector
c341 cso30:c:InputAssociation connector
c340 cso30:c:OutputProcess connector
p121_propro_p121
PMID: 18161744,12401407
These monocytes express high levels
of formyl-peptide receptor 1 (FPR1), which, when ligated,
suppresses the production of pro-inflammatory
cytokines and removes damaged cells
c342 cso30:c:InputProcess connector
c343 cso30:c:InputProcess connector
c344 cso30:c:OutputProcess connector
LPS_enti_MO000016882
LPS
TLR4:MD-2_enti_MO000038320
TLR4:MD-2
LPS:TLR4:MD-2_enti_MO000038315
LPS:TLR4:MD-2
LIpid A_enti_e5
LIpid A
Monophosphoryl Lipid A_enti_e6
Monophosphoryl Lipid A
Lipid IVa_enti_e11
Lipid IVa
LPS:TLR4:MD-2:Lipid A_enti_e12
LPS:TLR4:MD-2:Lipid A
MyD88_enti_MO000016573
MyD88
LPS:TLR4:MD-2:Lipid molecules:MyD88_enti_e13
LPS:TLR4:MD-2:Lipid molecules:MyD88
TRIF_enti_MO000041125
TRIF
LPS:TLR4:MD-2:Lipid A:TRIF_enti_e14
LPS:TLR4:MD-2:Lipid A:TRIF
LPS:TLR4:MD-2:Monophosphoryl Lipid A_enti_e15
LPS:TLR4:MD-2:Monophosphoryl Lipid A
LPS:TLR4:MD-2:Monophosphoryl Lipid A:TRIF_enti_e16
LPS:TLR4:MD-2:Monophosphoryl Lipid A:TRIF
LPS:TLR4:MD-2: Lipid IVA_enti_e17
LPS:TLR4:MD-2: Lipid IVA
Nod1_enti_MO000020434
Nod1
CARD4_enti_e18
CARD4
NOD1_enti_G011266
NOD1
CARD15 _enti_e19
CARD15
NOD2_enti_G011270
NOD2
Nod2_enti_MO000020461
Nod2
Bacteria_enti_e20
Bacteria
Bacterial products_enti_e21
Bacterial products
Nod2:Bacteria_enti_e22
Nod2:Bacteria
Nod1:Bacterial products_enti_e23
Nod1:Bacterial products
Nod2 oligomer:bacteria_enti_e24
Nod2 oligomer:bacteria
Nod1 oligomer:bacterial products_enti_e25
Nod1 oligomer:bacterial products
RIP2_enti_MO000017949
RIP2
Nod2 oligomer:Bacteria:RIP2_enti_e26
Nod2 oligomer:Bacteria:RIP2
Nod1 oligomer:Bacterial products:RIP2_enti_e27
Nod1 oligomer:Bacterial products:RIP2
IKK-gamma:IKK-beta:IKK-alpha_enti_MO000016599
IKK-gamma:IKK-beta:IKK-alpha
IKK-gamma{ub}:IKK-beta:IKK-alpha_enti_e28
IKK-gamma{ub}:IKK-beta:IKK-alpha
NF-kappaB_enti_MO000000058
NF-kappaB
NF-kappaB{active}_enti_e29
NF-kappaB{active}
NF-kappaB{active}_enti_e30
NF-kappaB{active}
GRIM19_enti_e31
GRIM19
TLR2_enti_MO000019397
TLR2
PGN_enti_MO000042032
PGN
TLR2:PGN_enti_e32
TLR2:PGN
DDX58_enti_MO000066987
DDX58
IFIH1_enti_MO000103999
IFIH1
3pRNA_enti_e33
3pRNA
DDX58:3pRNA_enti_e34
DDX58:3pRNA
Poly I:C_enti_e35
Poly I:C
IFIH1:Poly I:C_enti_e36
IFIH1:Poly I:C
Viral RNA_enti_e37
Viral RNA
OAS_enti_e38
OAS
OAS{active}_enti_e39
OAS{active}
ATP_enti_e40
ATP
2-5A_enti_e41
2-5A
RNase L_enti_e42
RNase L
RNase L{active}_enti_e43
RNase L{active}
Cellular RNA_enti_e44
Cellular RNA
small self RNA_enti_e45
small self RNA
IFIH1:small self RNA_enti_e46
IFIH1:small self RNA
DDX58:small self RNA_enti_e47
DDX58:small self RNA
MAVS_enti_MO000094908
MAVS
DDX58:3pRNA:MAVS_enti_e48
DDX58:3pRNA:MAVS
IFIH1:Poly I:C:MAVS_enti_e49
IFIH1:Poly I:C:MAVS
FADD:RIP-1:TRAF2:TRAF6_enti_e63
FADD:RIP-1:TRAF2:TRAF6
FADD:RIP-1:TRAF2:TRAF6{active}_enti_e64
FADD:RIP-1:TRAF2:TRAF6{active}
IKK-gamma:IKK-beta:IKK-alpha{active_enti_e65
IKK-gamma:IKK-beta:IKK-alpha{active
p50:RelA-p65:IkappaB-alpha_enti_MO000038724
p50:RelA-p65:IkappaB-alpha
p50:RelA-p65_enti_MO000016632
p50:RelA-p65
degradants_enti_e66
p50:RelA-p65_enti_e67
p50:RelA-p65
IFN-alpha_enti_e68
IFN-alpha
IFN-beta_enti_G010228
IFN-beta
TRAF3:NAP1:TANK:NEMO_enti_e69
TRAF3:NAP1:TANK:NEMO
IFIH1:Poly I:C:MAVS:TRAF3:NAP1:TANK:NEMO_enti_e70
IFIH1:Poly I:C:MAVS:TRAF3:NAP1:TANK:NEMO
DDX58:3pRNA:MAVS:TRAF3:NAP1:TANK:NEMO_enti_e71
DDX58:3pRNA:MAVS:TRAF3:NAP1:TANK:NEMO
TBK1:IKK-i_enti_MO000041445
TBK1:IKK-i
TBK1:IKK-i{active}_enti_e72
TBK1:IKK-i{active}
IRF-3_enti_MO000007694
IRF-3
IRF-3{active}_enti_e73
IRF-3{active}
IRF-7_enti_MO000007702
IRF-7
IRF-7{active}_enti_e74
IRF-7{active}
IRF-3:IRF-3{active}_enti_e75
IRF-3:IRF-3{active}
IRF-3:IRF-7{active}_enti_e76
IRF-3:IRF-7{active}
IRF-7:IRF-7{active}_enti_e77
IRF-7:IRF-7{active}
IRF-3:IRF-3{active}_enti_e78
IRF-3:IRF-3{active}
IRF-3:IRF-7{active}_enti_e79
IRF-3:IRF-7{active}
IRF-3:IRF-7{active}_enti_e80
IRF-3:IRF-7{active}
Hsp60_enti_MO000020119
Hsp60
LPS:TLR4:MD-2:Hsp60_enti_e81
LPS:TLR4:MD-2:Hsp60
NO_enti_e82
NO
TNF-alpha_enti_G010329
TNF-alpha
TNF-alpha_enti_MO000000289
TNF-alpha
Hsp70_enti_MO000021614
Hsp70
LPS:TLR4:MD-2:Hsp70_enti_e83
LPS:TLR4:MD-2:Hsp70
IL-12_enti_MO000017265
IL-12
IL-12 p40_enti_G010657
IL-12 p40
Gp96_enti_e84
Gp96
LPS:TLR4:MD-2:Gp96_enti_e85
LPS:TLR4:MD-2:Gp96
TLR2:PGN:Gp96_enti_e86
TLR2:PGN:Gp96
Pro-inflammatory cytokines_enti_e87
Pro-inflammatory cytokines
pro-inflammatory cytokines_enti_e88
pro-inflammatory cytokines
Co-stimulation factors_enti_e89
Co-stimulation factors
Co-stimulation factors_enti_e90
Co-stimulation factors
Hyaluronan_enti_e91
Hyaluronan
CD44_enti_MO000002553
CD44
Hyaluronan:CD44_enti_e92
Hyaluronan:CD44
Hyaluronan:TLR2_enti_e93
Hyaluronan:TLR2
TLR4:MD-2:Hyaluronan_enti_e94
TLR4:MD-2:Hyaluronan
Hyaluronic acid_enti_e95
Hyaluronic acid
Biglycan_enti_e96
Biglycan
HMGB1_enti_MO000044940
HMGB1
DNA_enti_e97
DNA
HMGB1:DNA_enti_e98
HMGB1:DNA
TLR4:MD-2:Fibronectin_enti_e100
TLR4:MD-2:Fibronectin
Beta-defensins_enti_e101
Beta-defensins
CCR6_enti_MO000019959
CCR6
Beta-defensins:CCR6_enti_e102
Beta-defensins:CCR6
Beta-defensin2_enti_e103
Beta-defensin2
Beta-defensin3_enti_e104
Beta-defensin3
EGFR_enti_MO000000108
EGFR
ERK_enti_MO000000011
ERK
Ox-LDL_enti_e105
Ox-LDL
CD36_enti_e106
CD36
Chemokines_enti_e107
Chemokines
chemokines_enti_e108
chemokines
TLR9_enti_MO000042012
TLR9
HMGB1_enti_e112
HMGB1
HMGB1:TLR9_enti_e113
HMGB1:TLR9
TLR4:MD2:HMGB1_enti_e114
TLR4:MD2:HMGB1
TLR2:HMGB1_enti_e115
TLR2:HMGB1
RAGE_enti_MO000069310
RAGE
HMGB1:RAGE_enti_e116
HMGB1:RAGE
CpG ODNs_enti_e117
CpG ODNs
HMGB1:RAGE:CpG ODNs_enti_e118
HMGB1:RAGE:CpG ODNs
HMGB1:RAGE:CpG ODNs:TLR9_enti_e119
HMGB1:RAGE:CpG ODNs:TLR9
fibronectin_enti_MO000017549
fibronectin
MMP-9_enti_G010279
MMP-9
Ox-LDL:CD36_enti_e99
Ox-LDL:CD36
Lox1_enti_e120
Lox1
Ox-LDL:Lox1_enti_e121
Ox-LDL:Lox1
ATP_enti_e122
ATP
IL-1beta_enti_G010389
IL-1beta
IL-1beta_enti_MO000016597
IL-1beta
IL-18_enti_MO000016625
IL-18
IL-18_enti_e123
IL-18
NALP3_enti_e124
NALP3
TLR ligands_enti_e125
TLR ligands
NALP3_enti_e126
NALP3
Nigericin_enti_e127
Nigericin
NALP3:Nigericin_enti_e128
NALP3:Nigericin
Maitotoxin_enti_e129
Maitotoxin
NALP3:Maitotoxin_enti_e130
NALP3:Maitotoxin
S.aureus_enti_e131
S.aureus
NALP3:s.aureus_enti_e132
NALP3:s.aureus
L.monocytogenes_enti_e133
L.monocytogenes
NALP3:L.monocytogenes_enti_e134
NALP3:L.monocytogenes
ASC_enti_MO000044014
ASC
Cardinal_enti_e135
Cardinal
NALP3:Maitotoxin:ASC:cardinal_enti_e136
NALP3:Maitotoxin:ASC:cardinal
Caspase-1_enti_e137
Caspase-1
proCaspase-1_enti_MO000018229
proCaspase-1
Mrp8_enti_e138
Mrp8
TLR4:MD-2:Mrp8_enti_e139
TLR4:MD-2:Mrp8
Mrp14_enti_e140
Mrp14
TLR4:MD-2:Mrp14_enti_e141
TLR4:MD-2:Mrp14
MyD88_enti_e142
MyD88
IRAK1_enti_e143
IRAK1
IRAK1_enti_e144
IRAK1
TNF_enti_e145
TNF
IL-10_enti_MO000017247
IL-10
B7-H4_enti_e146
B7-H4
Reg3g_enti_e147
Reg3g
Reg3g:PGN_enti_e148
Reg3g:PGN
COX-2_enti_MO000017266
COX-2
eicosapentaenoic acid_enti_e149
eicosapentaenoic acid
Resolvins_enti_e150
Resolvins
adenosine_enti_MO000017089
adenosine
ATPase-ADPase system_enti_e151
ATPase-ADPase system
A2AR_enti_e152
A2AR
A2AR:adenosine_enti_e153
A2AR:adenosine
A2BR_enti_e154
A2BR
A2BR:adenosine_enti_e155
A2BR:adenosine
A2AR agonist_enti_e156
A2AR agonist
A2AR:adenosine:A2AR agonist_enti_e157
A2AR:adenosine:A2AR agonist
A2BR agonist_enti_e158
A2BR agonist
A2BR:adenosine:A2BR agonist_enti_e159
A2BR:adenosine:A2BR agonist
IL-10_enti_e160
IL-10
VEGF_enti_G010711
VEGF
VEGF_enti_e161
VEGF
glucocorticoids_enti_MO000021732
glucocorticoids
FPR1_enti_e162
FPR1
FPR1:Glucocorticoids_enti_e163
FPR1:Glucocorticoids