Entity
TNF-alpha
--
G010329
cso30:c:mRNA
cso30:i:CC_CellComponent
--
csml-variable:Double
m93309
10
infinite
0
TRANSFAC | G010329 |
--
NF-kappaB
--
MO000000058
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m5
10
infinite
0
TRANSPATH | MO000000058 |
--
TNF-alpha
--
MO000000289
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m230
10
infinite
0
InterPro | IPR003636 |
TRANSPATH | MO000000289 |
--
calreticulin
--
MO000017520
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m2316
10
infinite
0
TRANSPATH | MO000017520 |
--
cytokines
--
MO000019387
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m3957
10
infinite
0
TRANSPATH | MO000019387 |
--
alpha2 beta1
--
MO000019699
cso30:c:Protein
cso30:i:CC_CellComponent
--
--
csml-variable:Double
m4234
10
infinite
0
TRANSPATH | MO000019699 |
--
CARD9 {activated}
--
MO000044196
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m21914
10
infinite
0
InterPro | IPR001315 |
TRANSPATH | MO000044196 |
--
MBL
--
MO000062069
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m36961
10
infinite
0
TRANSPATH | MO000062069 |
--
--
e1
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane
--
--
--
csml-variable:Double
m1
0
infinite
0
--
--
e10
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytosol
--
--
--
csml-variable:Double
m10
0
infinite
0
--
TLR ligand: TLR: TLR: MyD88
--
e11
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
csml-variable:Double
m12
0
infinite
0
--
TLR ligand: TLR: TLR: TRIF
--
e12
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m13
0
infinite
0
--
NF-kappaB {activated}
--
e13
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m14
10
infinite
0
TRANSPATH | MO000000058 |
--
mannose receptor
--
e15
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m16
0
infinite
0
--
csml-variable:Double
m17
0
infinite
0
--
csml-variable:Double
m18
0
infinite
0
--
N-acetyl glucosamine
--
e18
cso30:c:SmallMolecule
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m19
0
infinite
0
--
mannose: mannose receptor
--
e19
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m20
0
infinite
0
--
--
e2
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m2
0
infinite
0
--
fucose: mannose receptor
--
e20
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m21
0
infinite
0
--
N-acetyl glucosamine: mannose receptor
--
e21
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m22
0
infinite
0
--
csml-variable:Double
m23
0
infinite
0
--
mannan: DC-SIGN
--
e23
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
csml-variable:Double
m24
0
infinite
0
--
mannose receptor ligand
--
e24
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m25
0
infinite
0
--
mannose receptor ligand: mannose receptor
--
e25
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m26
0
infinite
0
--
csml-variable:Double
m27
10
infinite
0
Affymetrix | 1369_s_at |
Ensembl | ENSG00000169429 |
HGNC | IL8 |
OMIM | 146930 |
Proteome | HumanPSD/IL8 |
RefSeq | NM_000584 |
TRANSFAC | G000317 |
Unigene | Hs.551925 |
--
Dectin-1
--
e27
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m28
0
infinite
0
--
beta1, 3-glucans: Dectin-1
--
e28
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m29
0
infinite
0
--
beta1, 3-glucans
--
e29
cso30:c:SmallMolecule
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m30
0
infinite
0
--
--
e3
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
--
csml-variable:Double
m3
0
infinite
0
--
MIP-2
--
e30
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m31
0
infinite
0
--
csml-variable:Double
m32
0
infinite
0
--
csml-variable:Double
m33
0
infinite
0
--
csml-variable:Double
m34
0
infinite
0
--
Syk: beta1, 3-glucans: Dectin-1
--
e34
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m35
0
infinite
0
--
Dectin-2
--
e38
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m39
0
infinite
0
--
fucose: Dectin-2
--
e39
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m40
0
infinite
0
--
--
e4
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m4
0
infinite
0
--
mannose: Dectin-2
--
e40
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m41
0
infinite
0
--
Ca
--
e41
cso30:c:SmallMolecule
cso30:i:CC_Cytosol
--
csml-variable:Double
m42
0
infinite
0
--
mannan: DC-SIGN tetratmer
--
e42
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m43
0
infinite
0
--
DC-SIGN (murine)
--
e43
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m44
0
infinite
0
--
fungal particle
--
e44
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m45
0
infinite
0
--
fungal particle: DC-SIGN (murine)
--
e45
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
csml-variable:Double
m46
0
infinite
0
--
Raf kianse
--
e46
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m47
0
infinite
0
--
Raf kinase (activated}
--
e47
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m48
0
infinite
0
--
C1qRp: SP-D
--
e49
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m63
0
infinite
0
--
TLR liagnd
--
e5
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m6
0
infinite
0
--
--
e50
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelopeLumen
--
--
--
csml-variable:Double
m50
0
infinite
0
--
--
e51
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearPore
--
--
--
csml-variable:Double
m51
0
infinite
0
--
--
e52
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearInnerMembrane
--
--
--
csml-variable:Double
m52
0
infinite
0
--
--
e53
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearLumen
--
--
--
csml-variable:Double
m53
0
infinite
0
--
--
e54
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearOuterMembrane
--
--
--
csml-variable:Double
m54
0
infinite
0
--
--
e55
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleus
--
--
--
csml-variable:Double
m55
0
infinite
0
--
--
e56
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleoplasm
--
--
--
csml-variable:Double
m56
0
infinite
0
--
--
e57
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearBody
--
--
--
csml-variable:Double
m57
0
infinite
0
--
--
e58
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleolus
--
--
--
csml-variable:Double
m58
0
infinite
0
--
--
e59
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelope
--
--
--
csml-variable:Double
m59
0
infinite
0
--
TLR ligand: TLR: TLR
--
e6
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m11
0
infinite
0
--
--
e60
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Chromatin
--
--
--
csml-variable:Double
m60
0
infinite
0
--
--
e61
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearChromosome
--
--
--
csml-variable:Double
m61
0
infinite
0
--
--
e62
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearCentromere
--
--
--
csml-variable:Double
m62
0
infinite
0
--
C1qRp
--
e63
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m64
0
infinite
0
--
C1qRp: SP-A
--
e64
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m65
0
infinite
0
--
SIRPalpha: SP-A
--
e65
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m66
0
infinite
0
--
calreticulin: SP-A
--
e66
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m67
0
infinite
0
--
CD14: SP-A
--
e67
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m68
0
infinite
0
--
csml-variable:Double
m69
0
infinite
0
--
SP-A
--
e69
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m70
10
infinite
0
TRANSPATH | MO000071032 |
--
--
e7
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell
--
--
--
csml-variable:Double
m7
0
infinite
0
--
SP-D
--
e70
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m71
10
infinite
0
TRANSPATH | MO000066990 |
--
mannose receptor
--
e71
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m72
0
infinite
0
--
SIRPalpha: SP-D
--
e72
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m73
0
infinite
0
--
calreticulin: SP-D
--
e73
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m74
0
infinite
0
--
CD14: SP-D
--
e74
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m75
0
infinite
0
--
MBL: alpha2 beta1
--
e75
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m76
0
infinite
0
--
MBL: CR1
--
e76
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
csml-variable:Double
m77
0
infinite
0
--
MBL: calreticulin
--
e77
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m78
0
infinite
0
--
--
e8
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell_WithoutCellWall_
--
--
--
csml-variable:Double
m8
0
infinite
0
--
--
e9
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytoplasm
--
--
--
csml-variable:Double
m9
0
infinite
0
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1
m3962*m6*0.1
nodelay
--
0
PMID:18160296 Ligand recognition, by TLR homo- or hetero-dimers, induces signalling cascades mediated through intracellular adaptors, including myeloid differentiation primary response gene 88 (MyD88) and TIR-domain-containing adaptor-inducing interferon-beta (TRIF), which result in the activation of several transcription factors, such as NF-kappaB and interferon-regulatory factor 3 (IRF3).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c28 : 1
stoichiometry:c96 : 1
stoichiometry:c30 : 1
m25*m16*m42*0.1
nodelay
--
0
PMID: 18160296,15668126, 15155616, 17020928 In response to fungi, the MR can induce NF-kappaB activation and the production of several cytokines, including IL-12, IL-8, IL-1beta, IL-6 and granulocyte?macrophage colony-stimulating factor (GM-CSF), and can also enhance MR shedding. PMID: 18160296 A variety of endogenous and exogenous ligands have been described for the various domains of the MR, including the Ca2+-dependent recognition of carbohydrates.
p11
p11
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1
stoichiometry:c33 : 1
m26*m5*0.1
nodelay
--
0
PMID: 18160296, 15668126, 15155616, 17020928 In response to fungi, the MR can induce NF-kappaB activation and the production of several cytokines, including IL-12, IL-8, IL-1beta, IL-6 and granulocyte?macrophage colony-stimulating factor (GM-CSF), and can also enhance MR shedding.
p12
p12
cso30:i:ME_Translation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c46 : 1
stoichiometry:c34 : 1
m93589*m26*0.1
nodelay
--
0
PMID: 18160296,15668126, 15155616, 17020928 In response to fungi, the MR can induce NF-kappaB activation and the production of several cytokines, including IL-12, IL-8, IL-1beta, IL-6 and granulocyte?macrophage colony-stimulating factor (GM-CSF), and can also enhance MR shedding.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c41 : 1
stoichiometry:c47 : 1
stoichiometry:c35 : 1
m27*m26*0.1
nodelay
--
0
PMID: 18160296,15668126, 15155616, 17020928 In response to fungi, the MR can induce NF-kappaB activation and the production of several cytokines, including IL-12, IL-8, IL-1beta, IL-6 and granulocyte?macrophage colony-stimulating factor (GM-CSF), and can also enhance MR shedding.
p14
p14
cso30:i:ME_Translation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c42 : 1
stoichiometry:c48 : 1
stoichiometry:c36 : 1
m93364*m26*0.1
nodelay
--
0
PMID: 18160296,15668126, 15155616, 17020928 In response to fungi, the MR can induce NF-kappaB activation and the production of several cytokines, including IL-12, IL-8, IL-1beta, IL-6 and granulocyte?macrophage colony-stimulating factor (GM-CSF), and can also enhance MR shedding.
p15
p15
cso30:i:ME_Translation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c49 : 1
stoichiometry:c37 : 1
m93248*m26*0.1
nodelay
--
0
PMID: 18160296,15668126, 15155616, 17020928 In response to fungi, the MR can induce NF-kappaB activation and the production of several cytokines, including IL-12, IL-8, IL-1beta, IL-6 and granulocyte?macrophage colony-stimulating factor (GM-CSF), and can also enhance MR shedding.
p16
p16
cso30:i:ME_Translation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c50 : 1
stoichiometry:c38 : 1
m93209*m26*0.1
nodelay
--
0
PMID: 18160296,15668126, 15155616, 17020928 In response to fungi, the MR can induce NF-kappaB activation and the production of several cytokines, including IL-12, IL-8, IL-1beta, IL-6 and granulocyte?macrophage colony-stimulating factor (GM-CSF), and can also enhance MR shedding.
p17
p17
cso30:i:ME_Translation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c51 : 1
stoichiometry:c39 : 1
m93309*0.1
nodelay
--
0
PMID: 18160296,16000387 However, with certain fungi, such as Pneumocystis, the MR might have an immunosuppressive role, inhibiting the production inflammatory cytokines, such as tumour necrosis factor (TNF).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c53 : 1
stoichiometry:c54 : 1
m28*m30*0.1
nodelay
--
0
PMID: 18160296, 16341139, 16371356 Although most similar to CLRs with proteinaceous ligands, Dectin-1 recognises beta-1,3-glucans in a calcium-independent fashion through an unknown mechanism and is the major receptor for these carbohydrates on leukocytes.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c144 : 1
stoichiometry:c55 : 1
m32*m29*0.1
nodelay
--
0
PMID: 18160296, 16341139, 17450144 This induces a variety of cellular responses, including the respiratory burst, activation and regulation of phospholipase A2 (PLA2) and cyclooxygenase 2 (COX2), ligand uptake by endocytosis and phagocytosis and the production of several cytokines and chemokines, including TNF, macrophage inflammatory protein 2 (MIP-2), IL-2, IL-10, IL-6 and IL-23.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1
m11*m1572*0.1
nodelay
--
0
PMID:18160296 Ligand recognition, by TLR homo- or hetero-dimers, induces signalling cascades mediated through intracellular adaptors, including myeloid differentiation primary response gene 88 (MyD88) and TIR-domain-containing adaptor-inducing interferon-beta (TRIF), which result in the activation of several transcription factors, such as NF-kappaB and interferon-regulatory factor 3 (IRF3).
p20
p20
cso30:i:ME_Translation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c145 : 1
stoichiometry:c56 : 1
m93218*m29*0.1
nodelay
--
0
PMID: 18160296, 16341139, 17450144 This induces a variety of cellular responses, including the respiratory burst, activation and regulation of phospholipase A2 (PLA2) and cyclooxygenase 2 (COX2), ligand uptake by endocytosis and phagocytosis and the production of several cytokines and chemokines, including TNF, macrophage inflammatory protein 2 (MIP-2), IL-2, IL-10, IL-6 and IL-23.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c146 : 1
stoichiometry:c57 : 1
m33*m29*0.1
nodelay
--
0
PMID: 18160296, 16341139, 17450144 This induces a variety of cellular responses, including the respiratory burst, activation and regulation of phospholipase A2 (PLA2) and cyclooxygenase 2 (COX2), ligand uptake by endocytosis and phagocytosis and the production of several cytokines and chemokines, including TNF, macrophage inflammatory protein 2 (MIP-2), IL-2, IL-10, IL-6 and IL-23.
p22
p22
cso30:i:ME_Translation
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c81 : 1
stoichiometry:c73 : 1
m93248*m29*0.1
nodelay
--
0
PMID: 18160296, 16341139, 17450144 This induces a variety of cellular responses, including the respiratory burst, activation and regulation of phospholipase A2 (PLA2) and cyclooxygenase 2 (COX2), ligand uptake by endocytosis and phagocytosis and the production of several cytokines and chemokines, including TNF, macrophage inflammatory protein 2 (MIP-2), IL-2, IL-10, IL-6 and IL-23.
p23
p23
cso30:i:ME_Translation
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c82 : 1
stoichiometry:c151 : 1
stoichiometry:c75 : 1
m93309*m29*0.1
nodelay
--
0
PMID: 18160296, 16341139, 17450144 This induces a variety of cellular responses, including the respiratory burst, activation and regulation of phospholipase A2 (PLA2) and cyclooxygenase 2 (COX2), ligand uptake by endocytosis and phagocytosis and the production of several cytokines and chemokines, including TNF, macrophage inflammatory protein 2 (MIP-2), IL-2, IL-10, IL-6 and IL-23. PMID: 18160296,16000387 However, with certain fungi, such as Pneumocystis, the MR might have an immunosuppressive role, inhibiting the production inflammatory cytokines, such as tumour necrosis factor (TNF).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c62 : 1
stoichiometry:c63 : 1
m29*m1066*0.1
nodelay
--
0
PMID: 18160296, 16341139, 16862125 Signalling from Dectin-1 is mediated through novel pathways, including an unusual interaction with spleen tyrosine kinase (Syk), which triggers downstream signalling through caspase-recruitment domain 9 (CARD9).
p25
p25
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c64 : 1
stoichiometry:c66 : 1
stoichiometry:c65 : 1
m36*m35*0.1
nodelay
--
0
PMID: 18160296, 16341139, 16862125 Signalling from Dectin-1 is mediated through novel pathways, including an unusual interaction with spleen tyrosine kinase (Syk), which triggers downstream signalling through caspase-recruitment domain 9 (CARD9).
p26
p26
cso30:i:CE_CellDifferentiation
cso30:i:CC_Extracellular
--
--
PMID: 18160296, 17450144 The CARD9 pathway has been shown recently to induce DC maturation and direct T helper 17 (Th17)-cell responses independently of the TLRs, demonstrating that signalling through Dectin-1 can couple to adaptive immunity directly.
p27
p27
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c143 : 1
stoichiometry:c78 : 1
m1675*m29*0.1
nodelay
--
0
PMID: 18160296, 16341139, 17450144 This induces a variety of cellular responses, including the respiratory burst, activation and regulation of phospholipase A2 (PLA2) and cyclooxygenase 2 (COX2), ligand uptake by endocytosis and phagocytosis and the production of several cytokines and chemokines, including TNF, macrophage inflammatory protein 2 (MIP-2), IL-2, IL-10, IL-6 and IL-23.
p28
p28
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c142 : 1
stoichiometry:c80 : 1
m44388*m29*0.1
nodelay
--
0
PMID: 18160296, 16341139, 17450144 This induces a variety of cellular responses, including the respiratory burst, activation and regulation of phospholipase A2 (PLA2) and cyclooxygenase 2 (COX2), ligand uptake by endocytosis and phagocytosis and the production of several cytokines and chemokines, including TNF, macrophage inflammatory protein 2 (MIP-2), IL-2, IL-10, IL-6 and IL-23.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c97 : 1
stoichiometry:c85 : 1
m18*m39*0.1
nodelay
--
0
PMID: 18160296, 16423983 Dectin-2 possesses cation-dependent mannose and fucose lectin activity with specificity for high mannose structures.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1
m11*m18998*0.1
nodelay
--
0
PMID:18160296 Ligand recognition, by TLR homo- or hetero-dimers, induces signalling cascades mediated through intracellular adaptors, including myeloid differentiation primary response gene 88 (MyD88) and TIR-domain-containing adaptor-inducing interferon-beta (TRIF), which result in the activation of several transcription factors, such as NF-kappaB and interferon-regulatory factor 3 (IRF3).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c98 : 1
stoichiometry:c86 : 1
m17*m39*0.1
nodelay
--
0
PMID: 18160296, 16423983 Dectin-2 possesses cation-dependent mannose and fucose lectin activity with specificity for high mannose structures.
p31
p31
cso30:i:ME_Translation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c89 : 1
stoichiometry:c92 : 1
stoichiometry:c152 : 1
stoichiometry:c87 : 1
m93309*m41*0.1
nodelay
--
0
PMID: 18160296, 17050534 The cytoplasmic tail of Dectin-2 appears to associate through a novel interaction with the Fc¦Ã chain, a signalling adaptor associated with several other transmembrane receptors, and can induce TNF and IL-1R antagonist in response to hyphal forms of C. albicans. PMID: 18160296,16000387 However, with certain fungi, such as Pneumocystis, the MR might have an immunosuppressive role, inhibiting the production inflammatory cytokines, such as tumour necrosis factor (TNF).
p32
p32
cso30:i:ME_Translation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c90 : 1
stoichiometry:c91 : 1
stoichiometry:c153 : 1
stoichiometry:c88 : 1
m93309*m40*0.1
nodelay
--
0
PMID: 18160296, 17050534 The cytoplasmic tail of Dectin-2 appears to associate through a novel interaction with the Fc¦Ã chain, a signalling adaptor associated with several other transmembrane receptors, and can induce TNF and IL-1R antagonist in response to hyphal forms of C. albicans. PMID: 18160296,16000387 However, with certain fungi, such as Pneumocystis, the MR might have an immunosuppressive role, inhibiting the production inflammatory cytokines, such as tumour necrosis factor (TNF).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c100 : 1
stoichiometry:c101 : 1
m24*0.1
nodelay
--
0
PMID: 18160296, 15659060 DC-SIGN recognises carbohydrates, such as high-mannose structures, in a Ca2+-dependent fashion with specificity being achieved through unique interactions with its ligands and tetramerisation of the receptor.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c102 : 1
stoichiometry:c103 : 1
stoichiometry:c104 : 1
m44*m45*0.1
nodelay
--
0
PMID: 18160296, 15096474, 14707091 Of the murine homologues, only SIGNR1 (also termed murine DC-SIGN) and SIGNR3 recognise fungal particles.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c105 : 1
stoichiometry:c109 : 1
stoichiometry:c106 : 1
m47*m43*0.1
nodelay
--
0
PMID: 18160296, 17462920, 17496896 DC-SIGN can induce intracellular signalling through the Raf-kinase pathway, modulating TLR-mediated responses and inducing higher levels of the immunosuppressive cytokine IL-10.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c108 : 1
stoichiometry:c107 : 1
m48*0.1
nodelay
--
0
PMID: 18160296, 17462920, 17496896 DC-SIGN can induce intracellular signalling through the Raf-kinase pathway, modulating TLR-mediated responses and inducing higher levels of the immunosuppressive cytokine IL-10.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c116 : 1
stoichiometry:c110 : 1
stoichiometry:c118 : 1
m70*m64*0.1
nodelay
--
0
PMID: 18160296, 16213021 Similar to MBP, these collectins have been proposed to bind directly to cellular receptors, including C1q receptor (C1qRp), signal-regulating protein alpha (SIRPalpha), calreticulin and CD14.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c111 : 1
stoichiometry:c117 : 1
stoichiometry:c119 : 1
m49*m70*0.1
nodelay
--
0
PMID: 18160296, 16213021 Similar to MBP, these collectins have been proposed to bind directly to cellular receptors, including C1q receptor (C1qRp), signal-regulating protein alpha (SIRPalpha), calreticulin and CD14.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c112 : 1
stoichiometry:c130 : 1
stoichiometry:c120 : 1
m2316*m70*0.1
nodelay
--
0
PMID: 18160296, 16213021 Similar to MBP, these collectins have been proposed to bind directly to cellular receptors, including C1q receptor (C1qRp), signal-regulating protein alpha (SIRPalpha), calreticulin and CD14.
p4
p4
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c14 : 1
stoichiometry:c11 : 1
m5*m12*0.1
nodelay
--
0
PMID:18160296 Ligand recognition, by TLR homo- or hetero-dimers, induces signalling cascades mediated through intracellular adaptors, including myeloid differentiation primary response gene 88 (MyD88) and TIR-domain-containing adaptor-inducing interferon-beta (TRIF), which result in the activation of several transcription factors, such as NF-kappaB and interferon-regulatory factor 3 (IRF3).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c113 : 1
stoichiometry:c131 : 1
stoichiometry:c121 : 1
m2828*m70*0.1
nodelay
--
0
PMID: 18160296, 16213021 Similar to MBP, these collectins have been proposed to bind directly to cellular receptors, including C1q receptor (C1qRp), signal-regulating protein alpha (SIRPalpha), calreticulin and CD14.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c124 : 1
stoichiometry:c127 : 1
stoichiometry:c122 : 1
m69*m70*0.1
nodelay
--
0
PMID: 18160296, 11181966 Through unknown mechanisms, SP-A and SP-D can also modulate a variety of host cell functions, such as phagocytosis, cytokine production and the respiratory burst.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c125 : 1
stoichiometry:c126 : 1
stoichiometry:c123 : 1
m69*m71*0.1
nodelay
--
0
PMID: 18160296, 11181966 Through unknown mechanisms, SP-A and SP-D can also modulate a variety of host cell functions, such as phagocytosis, cytokine production and the respiratory burst.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c128 : 1
stoichiometry:c129 : 1
m16*0.1
nodelay
--
0
PMID: 18160296 A soluble form of the MR is shed into the serum, which is generated through proteolytic cleavage of the membrane-bound receptor.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c114 : 1
stoichiometry:c132 : 1
stoichiometry:c136 : 1
m64*m71*0.1
nodelay
--
0
PMID: 18160296, 16213021 Similar to MBP, these collectins have been proposed to bind directly to cellular receptors, including C1q receptor (C1qRp), signal-regulating protein alpha (SIRPalpha), calreticulin and CD14.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c115 : 1
stoichiometry:c133 : 1
stoichiometry:c137 : 1
m49*m71*0.1
nodelay
--
0
PMID: 18160296, 16213021 Similar to MBP, these collectins have been proposed to bind directly to cellular receptors, including C1q receptor (C1qRp), signal-regulating protein alpha (SIRPalpha), calreticulin and CD14.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c134 : 1
stoichiometry:c140 : 1
stoichiometry:c138 : 1
m71*m2316*0.1
nodelay
--
0
PMID: 18160296, 16213021 Similar to MBP, these collectins have been proposed to bind directly to cellular receptors, including C1q receptor (C1qRp), signal-regulating protein alpha (SIRPalpha), calreticulin and CD14.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c135 : 1
stoichiometry:c141 : 1
stoichiometry:c139 : 1
m71*m2828*0.1
nodelay
--
0
PMID: 18160296, 16213021 Similar to MBP, these collectins have been proposed to bind directly to cellular receptors, including C1q receptor (C1qRp), signal-regulating protein alpha (SIRPalpha), calreticulin and CD14.
p48
p48
cso30:i:ME_Binding
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c68 : 1
stoichiometry:c69 : 1
m4234*m36961*0.1
nodelay
--
0
PMID: 18160296, 12524383, 16166590 The identity of the MBL receptor(s) is controversial, although a number have been proposed, including calreticulin, complement receptor 1 and the integrin.
p49
p49
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1
stoichiometry:c150 : 1
stoichiometry:c71 : 1
m36961*m2316*0.1
nodelay
--
0
PMID: 18160296, 12524383, 16166590 The identity of the MBL receptor(s) is controversial, although a number have been proposed, including calreticulin, complement receptor 1 and the integrin.
p5
p5
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c12 : 1
stoichiometry:c15 : 1
stoichiometry:c13 : 1
m977*m13*0.1
nodelay
--
0
PMID:18160296 Ligand recognition, by TLR homo- or hetero-dimers, induces signalling cascades mediated through intracellular adaptors, including myeloid differentiation primary response gene 88 (MyD88) and TIR-domain-containing adaptor-inducing interferon-beta (TRIF), which result in the activation of several transcription factors, such as NF-kappaB and interferon-regulatory factor 3 (IRF3).
p50
p50
cso30:i:ME_Binding
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c147 : 1
stoichiometry:c148 : 1
stoichiometry:c149 : 1
m36961*m45367*0.1
nodelay
--
0
PMID: 18160296, 12524383, 16166590 The identity of the MBL receptor(s) is controversial, although a number have been proposed, including calreticulin, complement receptor 1 and the integrin.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c93 : 1
stoichiometry:c22 : 1
m16*m17*m42*0.1
nodelay
--
0
PMID: 18160296, 15668126 This activity is mediated by CTLD 4?8 of the receptor, which bind terminal mannose, fucose or N-acetyl glucosamine and is responsible for microbial recognition. PMID: 18160296 A variety of endogenous and exogenous ligands have been described for the various domains of the MR, including the Ca2+-dependent recognition of carbohydrates.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c18 : 1
stoichiometry:c20 : 1
stoichiometry:c94 : 1
stoichiometry:c23 : 1
m16*m18*m42*0.1
nodelay
--
0
PMID: 18160296, 15668126 This activity is mediated by CTLD 4?8 of the receptor, which bind terminal mannose, fucose or N-acetyl glucosamine and is responsible for microbial recognition. PMID: 18160296 A variety of endogenous and exogenous ligands have been described for the various domains of the MR, including the Ca2+-dependent recognition of carbohydrates.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c21 : 1
stoichiometry:c95 : 1
stoichiometry:c24 : 1
m16*m19*m42*0.1
nodelay
--
0
PMID: 18160296, 15668126 This activity is mediated by CTLD 4?8 of the receptor, which bind terminal mannose, fucose or N-acetyl glucosamine and is responsible for microbial recognition. PMID: 18160296 A variety of endogenous and exogenous ligands have been described for the various domains of the MR, including the Ca2+-dependent recognition of carbohydrates.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c99 : 1
stoichiometry:c27 : 1
m23*m20214*m42*0.1
nodelay
--
0
PMID: 18160296, 2828085 We now know that mannan can be recognised by several mannose-receptors, such as DC-SIGN, and is often contaminated with other carbohydrates involved in fungal recognition, such as beta-glucan. PMID: 18160296, 15659060 DC-SIGN recognises carbohydrates, such as high-mannose structures, in a Ca2+-dependent fashion with specificity being achieved through unique interactions with its ligands and tetramerisation of the receptor.
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--