Entity
TRAF6
--
MO000000212
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m183
10
infinite
0
InterPro | IPR001841 |
TRANSPATH | MO000000212 |
--
MyD88
--
MO000016573
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m1572
10
infinite
0
InterPro | IPR000157 |
TRANSPATH | MO000016573 |
--
IFN Type I
--
MO000016658
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m1634
10
infinite
0
TRANSPATH | MO000016658 |
--
beta-arrestin
--
MO000017072
cso30:c:Protein
cso30:i:CC_CellComponent
--
--
csml-variable:Double
m1964
10
infinite
0
TRANSPATH | MO000017072 |
--
protein remnants
--
MO000019479
cso30:c:Protein
cso30:i:CC_CellComponent
--
--
csml-variable:Double
m360980
10
infinite
0
TRANSPATH | MO000019479 |
--
flagellin
--
MO000022185
cso30:c:Protein
cso30:i:CC_CellComponent
--
--
csml-variable:Double
m6485
10
infinite
0
TRANSPATH | MO000022185 |
--
TRIAD3
--
MO000061958
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m36851
10
infinite
0
TRANSPATH | MO000061958 |
--
SIGIRR
--
MO000066718
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m41575
10
infinite
0
TRANSPATH | MO000066718 |
--
--
e1
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane
--
--
--
csml-variable:Double
m1
0
infinite
0
--
--
e10
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytosol
--
--
--
csml-variable:Double
m10
0
infinite
0
--
TLR ligand: TLR: MAL
--
e11
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m11
0
infinite
0
--
TLR ligand: TLR: MAL: MyD88
--
e12
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m12
0
infinite
0
--
TLR ligand: TLR: MyD88: MAL: IRAK-4
--
e13
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m13
0
infinite
0
--
IRAK1 {p}
--
e14
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m14
0
infinite
0
--
IRAK1 {p}: TRAF6
--
e15
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m15
0
infinite
0
--
csml-variable:Double
m16
0
infinite
0
--
TAk1: TAB2 (activated}
--
e17
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m17
0
infinite
0
--
NF-kappaB {activated}
--
e19
cso30:c:Protein
cso30:i:CC_CellComponent
--
--
csml-variable:Double
m20
10
infinite
0
TRANSPATH | MO000000058 |
--
--
e2
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m2
0
infinite
0
--
TLR7 ligand: TLR7: MyD88
--
e21
cso30:c:Complex
cso30:i:CC_EndosomeLumen
--
csml-variable:Double
m22
0
infinite
0
--
TLR3 ligand
--
e22
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m23
0
infinite
0
--
LPS: TLR4
--
e23
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m24
0
infinite
0
--
TLR3 ligand: TLR3
--
e24
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m25
0
infinite
0
--
LPS: TLR4: TRAM
--
e25
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m26
0
infinite
0
--
LPS: TLR4: TRAM: TRIF
--
e26
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
csml-variable:Double
m27
0
infinite
0
--
TLR3 ligand: TLR3: TRIF
--
e27
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m28
0
infinite
0
--
--
e29
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Endosome
--
--
--
csml-variable:Double
m30
0
infinite
0
--
--
e3
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
--
csml-variable:Double
m3
0
infinite
0
--
--
e30
cso30:c:EntityBiologicalCompartment
cso30:i:CC_EndosomeMembrane
--
--
--
csml-variable:Double
m31
0
infinite
0
--
--
e31
cso30:c:EntityBiologicalCompartment
cso30:i:CC_EndosomeLumen
--
--
--
csml-variable:Double
m32
0
infinite
0
--
TLR7 ligand: TLR7
--
e32
cso30:c:Complex
cso30:i:CC_EndosomeLumen
--
csml-variable:Double
m33
0
infinite
0
--
TLR8 ligand: TLR8
--
e33
cso30:c:Complex
cso30:i:CC_EndosomeLumen
--
csml-variable:Double
m34
0
infinite
0
--
TLR9 ligand: TLR9
--
e34
cso30:c:Complex
cso30:i:CC_EndosomeLumen
--
csml-variable:Double
m35
0
infinite
0
--
TLR7 ligand
--
e35
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m36
0
infinite
0
--
TLR8 ligand
--
e36
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m37
0
infinite
0
--
TLR9 ligand
--
e37
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m38
0
infinite
0
--
csml-variable:Double
m39
0
infinite
0
--
TLR8 ligand: TLR8: MyD88
--
e39
cso30:c:Complex
cso30:i:CC_EndosomeLumen
--
csml-variable:Double
m40
0
infinite
0
--
--
e4
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m4
0
infinite
0
--
TLR9 ligand: TLR9: MyD88
--
e40
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m41
0
infinite
0
--
LPS: TLR4: MyD88
--
e42
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m43
0
infinite
0
--
LPS: TLR4: MyD88: MAL
--
e43
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m44
0
infinite
0
--
MyD88s
--
e44
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m45
0
infinite
0
--
TLR ligand: TLR: MyD88: MAL: IRAK-4: IRAK1
--
e45
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m46
0
infinite
0
--
MyD88: IRAK: TRAF6
--
e46
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m47
0
infinite
0
--
MyD88: IRAK: TRAF6: IRF-4
--
e47
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m48
0
infinite
0
--
TLR ligand: TLR: MyD88: MAL: IRAK-4: IRAK1{p}
--
e48
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m49
0
infinite
0
--
Smad6: Pellino: IRAK1: TRAF6
--
e49
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m63
0
infinite
0
--
TLR ligand
--
e5
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m5
0
infinite
0
--
--
e50
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelopeLumen
--
--
--
csml-variable:Double
m50
0
infinite
0
--
--
e51
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearPore
--
--
--
csml-variable:Double
m51
0
infinite
0
--
--
e52
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearInnerMembrane
--
--
--
csml-variable:Double
m52
0
infinite
0
--
--
e53
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearLumen
--
--
--
csml-variable:Double
m53
0
infinite
0
--
--
e54
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearOuterMembrane
--
--
--
csml-variable:Double
m54
0
infinite
0
--
--
e55
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleus
--
--
--
csml-variable:Double
m55
0
infinite
0
--
--
e56
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleoplasm
--
--
--
csml-variable:Double
m56
0
infinite
0
--
--
e57
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearBody
--
--
--
csml-variable:Double
m57
0
infinite
0
--
--
e58
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleolus
--
--
--
csml-variable:Double
m58
0
infinite
0
--
--
e59
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelope
--
--
--
csml-variable:Double
m59
0
infinite
0
--
TLR ligand: TLR
--
e6
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m6
0
infinite
0
--
--
e60
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Chromatin
--
--
--
csml-variable:Double
m60
0
infinite
0
--
--
e61
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearChromosome
--
--
--
csml-variable:Double
m61
0
infinite
0
--
--
e62
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearCentromere
--
--
--
csml-variable:Double
m62
0
infinite
0
--
IRAK 1{p}: TRAF6 {ub}
--
e63
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m64
0
infinite
0
--
TRAF6: beta-arrestin
--
e64
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m65
0
infinite
0
--
flagellin: TLR5
--
e65
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m66
0
infinite
0
--
MCP-5
--
e66
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m67
0
infinite
0
--
MCP5
--
e67
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
--
csml-variable:Double
m68
0
infinite
0
--
MCP-1: CCr2
--
e68
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m70
0
infinite
0
--
MCP-5: CCR2
--
e69
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m71
0
infinite
0
--
--
e7
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell
--
--
--
csml-variable:Double
m7
0
infinite
0
--
SARM
--
e71
cso30:c:Protein
cso30:i:CC_Extracellular
--
csml-variable:Double
m73
0
infinite
0
--
--
e8
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell_WithoutCellWall_
--
--
--
csml-variable:Double
m8
0
infinite
0
--
--
e9
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytoplasm
--
--
--
csml-variable:Double
m9
0
infinite
0
--
p1
p1
cso30:i:ME_Binding
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1
m5*m3962*0.1
nodelay
--
0
PMID: 18086373, 9697844, 10435584 MyD88 is the central adapter protein for signal transduction of all TLRs, except TLR3, and the interleukin (IL)-1 receptor family.
p10
p10
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c30 : 1
stoichiometry:c29 : 1
m219*m18*0.1
nodelay
--
0
PMID: 18086373 Finally, nuclear factor kappaB (NF-kappaB) and activator protein 1 (AP-1) transcription factors are activated resulting in the transcription of inflammatory genes.
p11
p11
cso30:i:ME_Binding
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1
stoichiometry:c31 : 1
stoichiometry:c75 : 1
stoichiometry:c85 : 1
stoichiometry:c33 : 1
m3961*m155666*0.1
nodelay
--
0
PMID: 18086373, 12872135, 12471095, 14625548 Engagement of TLR4 and TLR3 induces the TRIF-dependent signaling pathway, which is essential for the production of interferon (IFN)-betaand contributes to the expression of cytokines and costimulatory molecules through both IFN-beta-dependent and -independent mechanisms. PMID: 18086373, 15852007 Radioprotective 105 (RP105) is a member of the TLR family and interferes with TLR4 signaling by inhibition of ligand binding. PMID: 18086373, 15866876 SIGIRR is not able to induce NF-¦ÊB signaling by itself, but inhibits LPS-induced signaling probably by interference with the TIR domain of TLR4 and TLR9.
p12
p12
cso30:i:ME_Binding
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c35 : 1
stoichiometry:c36 : 1
m3965*m23*0.1
nodelay
--
0
PMID: 18086373, 12872135, 12471095, 14625548 Engagement of TLR4 and TLR3 induces the TRIF-dependent signaling pathway, which is essential for the production of interferon (IFN)-betaand contributes to the expression of cytokines and costimulatory molecules through both IFN-beta-dependent and -independent mechanisms.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c38 : 1
stoichiometry:c39 : 1
m24*m19005*0.1
nodelay
--
0
PMID: 18086373, 14517278, 12539043, 12539043 TLR4-induced TRIF signaling involves the adapter Toll-receptor-associated molecule (TRAM), whereas the interaction of TLR3 with TRIF is TRAM-independent.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c43 : 1
stoichiometry:c146 : 1
stoichiometry:c44 : 1
m18998*m26*0.1
nodelay
--
0
PMID: 18086373, 12872135, 12471095, 14625548 Engagement of TLR4 and TLR3 induces the TRIF-dependent signaling pathway, which is essential for the production of interferon (IFN)-betaand contributes to the expression of cytokines and costimulatory molecules through both IFN-beta-dependent and -independent mechanisms. PMID: 18086373, 16964262 TRIF-induced signaling, however, is negatively regulated by the TIR adapter sterile a HEAT-Armadillo motif protein (SARM) in humans.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c41 : 1
stoichiometry:c42 : 1
stoichiometry:c147 : 1
stoichiometry:c45 : 1
m18998*m25*0.1
nodelay
--
0
PMID: 18086373, 12872135, 12471095, 14625548 Engagement of TLR4 and TLR3 induces the TRIF-dependent signaling pathway, which is essential for the production of interferon (IFN)-betaand contributes to the expression of cytokines and costimulatory molecules through both IFN-beta-dependent and -independent mechanisms. PMID: 18086373, 16964262 TRIF-induced signaling, however, is negatively regulated by the TIR adapter sterile a HEAT-Armadillo motif protein (SARM) in humans.
p16
p16
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c48 : 1
stoichiometry:c49 : 1
stoichiometry:c50 : 1
stoichiometry:c51 : 1
stoichiometry:c109 : 1
stoichiometry:c47 : 1
m977*m3902*m1599*m27*m28*0.1
nodelay
--
0
PMID: 18086373, 14530355, 14739303 TRIF-induced production of IFN-beta is critically regulated by the noncanonical inhibitory factor kappaB (IkappaB) kinases TRAF family member associated NF-kappaB activator (TANK)-binding kinase 1 (TBK1) and IkappaB kinase (IKK)epsilon followed by phosphorylation and nuclear translocation of interferon regulatory factor (IRF)3. PMID: 18086373, 17157040 Furthermore, the TRIF pathway is negatively regulated by Src homology 2(SH2)-domain-containing inositol-5-phosphatase (SHIP)-2 through interference with TANK-binding kinase 1 (TBK)1-induced signaling.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c53 : 1
m19324*0.1
nodelay
--
0
PMID: 18086373, 14530355, 14739303 TRIF-induced production of IFN-beta is critically regulated by the noncanonical inhibitory factor kappaB (IkappaB) kinases TRAF family member associated NF-kappaB activator (TANK)-binding kinase 1 (TBK1) and IkappaB kinase (IKK)epsilon followed by phosphorylation and nuclear translocation of interferon regulatory factor (IRF)3.
p18
p18
cso30:i:ME_Translation
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c56 : 1
stoichiometry:c55 : 1
m93217*m29*0.1
nodelay
--
0
PMID: 18086373, 14530355, 14739303 TRIF-induced production of IFN-beta is critically regulated by the noncanonical inhibitory factor kappaB (IkappaB) kinases TRAF family member associated NF-kappaB activator (TANK)-binding kinase 1 (TBK1) and IkappaB kinase (IKK)epsilon followed by phosphorylation and nuclear translocation of interferon regulatory factor (IRF)3.
p19
p19
cso30:i:ME_Binding
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c57 : 1
stoichiometry:c58 : 1
stoichiometry:c59 : 1
m36*m19940*0.1
nodelay
--
0
PMID: 18086373, 12356687, 15361868 Type-I interferon production can also be triggered by TLR7, TLR8 and TLR9 in an MyD88-dependent fashion.
p2
p2
cso30:i:ME_Binding
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c5 : 1
stoichiometry:c7 : 1
stoichiometry:c9 : 1
m1572*m11*0.1
nodelay
--
0
PMID: 18086373, 9697844, 10435584 MyD88 is the central adapter protein for signal transduction of all TLRs, except TLR3, and the interleukin (IL)-1 receptor family.
p20
p20
cso30:i:ME_Binding
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c61 : 1
stoichiometry:c62 : 1
m37*m19823*0.1
nodelay
--
0
PMID: 18086373, 12356687, 15361868 Type-I interferon production can also be triggered by TLR7, TLR8 and TLR9 in an MyD88-dependent fashion.
p21
p21
cso30:i:ME_Binding
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c63 : 1
stoichiometry:c64 : 1
stoichiometry:c86 : 1
stoichiometry:c65 : 1
m38*m19828*0.1
nodelay
--
0
PMID: 18086373, 12356687, 15361868 Type-I interferon production can also be triggered by TLR7, TLR8 and TLR9 in an MyD88-dependent fashion.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c66 : 1
stoichiometry:c81 : 1
stoichiometry:c74 : 1
m39*m41*0.1
nodelay
--
0
PMID: 18086373, 12356687, 15361868 Type-I interferon production can also be triggered by TLR7, TLR8 and TLR9 in an MyD88-dependent fashion.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1
stoichiometry:c80 : 1
stoichiometry:c73 : 1
m39*m40*0.1
nodelay
--
0
PMID: 18086373, 12356687, 15361868 Type-I interferon production can also be triggered by TLR7, TLR8 and TLR9 in an MyD88-dependent fashion.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c71 : 1
stoichiometry:c79 : 1
stoichiometry:c72 : 1
m39*m22*0.1
nodelay
--
0
PMID: 18086373, 12356687, 15361868 Type-I interferon production can also be triggered by TLR7, TLR8 and TLR9 in an MyD88-dependent fashion.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c76 : 1
stoichiometry:c82 : 1
m33*m1572*0.1
nodelay
--
0
PMID: 18086373, 12356687, 15361868 Type-I interferon production can also be triggered by TLR7, TLR8 and TLR9 in an MyD88-dependent fashion.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1
stoichiometry:c77 : 1
stoichiometry:c83 : 1
m34*m1572*0.1
nodelay
--
0
PMID: 18086373, 12356687, 15361868 Type-I interferon production can also be triggered by TLR7, TLR8 and TLR9 in an MyD88-dependent fashion.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c78 : 1
stoichiometry:c84 : 1
m35*m1572*0.1
nodelay
--
0
PMID: 18086373, 12356687, 15361868 Type-I interferon production can also be triggered by TLR7, TLR8 and TLR9 in an MyD88-dependent fashion.
p28
p28
cso30:i:ME_ProteasomeDegradation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c91 : 1
stoichiometry:c89 : 1
m36851*m3961*0.1
nodelay
--
0
PMID: 18086373, 15107846 The E3-ubiqiutin ligase TLR-ubiquitinating enzyme 3A (Triad3A), however, inhibits TLR signaling by the promotion of proteolytic degradation of TLR4 and TLR9.
p29
p29
cso30:i:ME_ProteasomeDegradation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c88 : 1
stoichiometry:c92 : 1
stoichiometry:c90 : 1
m36851*m19828*0.1
nodelay
--
0
PMID: 18086373, 15107846 The E3-ubiqiutin ligase TLR-ubiquitinating enzyme 3A (Triad3A), however, inhibits TLR signaling by the promotion of proteolytic degradation of TLR4 and TLR9.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c8 : 1
stoichiometry:c4 : 1
stoichiometry:c6 : 1
m43675*m6*0.1
nodelay
--
0
PMID: 18086373 MyD88 needs the bridging adapter MyD88-adapter-like /TIR-associated protein (Mal/TIRAP) for signaling induced by TLR2 and TLR4.
p30
p30
cso30:i:ME_Binding
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c94 : 1
stoichiometry:c99 : 1
stoichiometry:c95 : 1
m24*m1572*0.1
nodelay
--
0
PMID: 18086373, 15004556 ST2L inhibits signaling induced by TLR4 and IL1-R but not by TLR3, probably by sequestering MyD88 and Mal.
p31
p31
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c96 : 1
stoichiometry:c97 : 1
stoichiometry:c100 : 1
stoichiometry:c98 : 1
m43*m43675*0.1
nodelay
--
0
PMID: 18086373, 15004556 ST2L inhibits signaling induced by TLR4 and IL1-R but not by TLR3, probably by sequestering MyD88 and Mal.
p32
p32
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c15 : 1
stoichiometry:c104 : 1
stoichiometry:c118 : 1
stoichiometry:c101 : 1
m13*m184*0.1
nodelay
--
0
PMID: 18086373, 12538665 MyD88-signaling is inhibited by a splice variant of MyD88, MyD88s, which lacks the intermediate domain of MyD88 and acts as dominant negative inhibitor of the MyD88/IRAK complex by preventing the phosphorylation of IRAK-1. PMID: 18086373, 16951688 Recently, Smad6 was identified to abrogate TLR signaling by complex formation with Pelle-interacting protein (Pellino), IRAK-1 and TRAF6.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c107 : 1
stoichiometry:c108 : 1
m47*m978*0.1
nodelay
--
0
PMID: 18086373, 16243976, 16236719 In addition, IRF-4 interacts with the IRAK-1/MyD88/TRAF-6 complex and selectively inhibits IRF-5-dependent TLR signaling.
p34
p34
cso30:i:ME_Dissociation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c103 : 1
stoichiometry:c112 : 1
stoichiometry:c110 : 1
stoichiometry:c111 : 1
m49*0.1
nodelay
--
0
PMID: 18086373 IRAK-M inhibits the dissociation of IRAK-1 and IRAK-4 from the TLR/MyD88/IRAK signaling complex.
p35
p35
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c114 : 1
stoichiometry:c115 : 1
stoichiometry:c116 : 1
stoichiometry:c117 : 1
stoichiometry:c120 : 1
m184*m2522*m183*m19288*0.1
nodelay
--
0
PMID: 18086373, 16951688 Recently, Smad6 was identified to abrogate TLR signaling by complex formation with Pelle-interacting protein (Pellino), IRAK-1 and TRAF6.
p36
p36
cso30:i:ME_Ubiquitination
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c123 : 1
stoichiometry:c127 : 1
stoichiometry:c121 : 1
m15*0.1
nodelay
--
0
PMID: 18086373 Moreover, A20 removes K63-linked ubiquitin residues from TRAF6 and therefore inhibits TRAF6 dependent NF-kappaB activation, while beta-arrestin complexes with TRAF6 and averts autoubiqitination and NF-kappaB activation by TRAF6.
p37
p37
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c124 : 1
stoichiometry:c125 : 1
stoichiometry:c126 : 1
m1964*m183*0.1
nodelay
--
0
PMID: 18086373 Moreover, A20 removes K63-linked ubiquitin residues from TRAF6 and therefore inhibits TRAF6 dependent NF-kappaB activation, while beta-arrestin complexes with TRAF6 and averts autoubiqitination and NF-kappaB activation by TRAF6.
p38
p38
cso30:i:ME_Binding
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c128 : 1
stoichiometry:c129 : 1
stoichiometry:c130 : 1
m3966*m6485*0.1
nodelay
--
0
PMID: 18086373 Bacterial flagellin is recognized by TLR5.
p39
p39
cso30:i:ME_Binding
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c137 : 1
stoichiometry:c138 : 1
stoichiometry:c141 : 1
m4436*m2133*0.1
nodelay
--
0
PMID: 18086373, 15517610 Antibody blockade of CCR2, which functions as a receptor for MCP-1 and MCP-5, demonstrated that this pathway is essential for neutrophil recruitment, bacterial clearance and prevention of kidney injury in septic peritonitis.
p4
p4
cso30:i:ME_Binding
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c12 : 1
stoichiometry:c11 : 1
m17258*m12*0.1
nodelay
--
0
PMID: 18086373, 12885415 MyD88 recruits IL-1 receptor-associated kinase (IRAK)-4 which phosphorylates IRAK-1.
p40
p40
cso30:i:ME_Binding
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c139 : 1
stoichiometry:c140 : 1
stoichiometry:c142 : 1
m4436*m67*0.1
nodelay
--
0
PMID: 18086373, 15517610 Antibody blockade of CCR2, which functions as a receptor for MCP-1 and MCP-5, demonstrated that this pathway is essential for neutrophil recruitment, bacterial clearance and prevention of kidney injury in septic peritonitis.
p41
p41
cso30:i:ME_GeneExpression
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c133 : 1
stoichiometry:c135 : 1
stoichiometry:c132 : 1
m28*0.1
nodelay
--
0
PMID: 18086373, 15517610, 16714594 In the absence of MyD88, TRIF-regulated inflammatory genes including Monocyte chemoattractant protein-1 (MCP-1) and Monocyte chemoattractant protein-5 (MCP-5) were found to be induced during sepsis.
p42
p42
cso30:i:ME_GeneExpression
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c134 : 1
stoichiometry:c136 : 1
stoichiometry:c131 : 1
m28*0.1
nodelay
--
0
PMID: 18086373, 15517610, 16714594 In the absence of MyD88, TRIF-regulated inflammatory genes including Monocyte chemoattractant protein-1 (MCP-1) and Monocyte chemoattractant protein-5 (MCP-5) were found to be induced during sepsis.
p43
p43
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c143 : 1
stoichiometry:c145 : 1
stoichiometry:c144 : 1
m980*m27*0.1
nodelay
--
0
PMID: 18086373 TLR signaling procedes via the adapters TIRAP/MyD88 or TRAM/TRIF to activate NF-kappaB or IRF3 and IRF7 transcription factors.
p5
p5
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c105 : 1
stoichiometry:c14 : 1
stoichiometry:c113 : 1
stoichiometry:c102 : 1
m46*0.1
nodelay
--
0
PMID: 18086373, 12885415 MyD88 recruits IL-1 receptor-associated kinase (IRAK)-4 which phosphorylates IRAK-1. PMID: 18086373, 12538665 MyD88-signaling is inhibited by a splice variant of MyD88, MyD88s, which lacks the intermediate domain of MyD88 and acts as dominant negative inhibitor of the MyD88/IRAK complex by preventing the phosphorylation of IRAK-1. PMID: 18086373, 11751856 Toll-interacting protein (Tollip) was shown to inhibit phosphorylation and kinase activity of IRAK-1.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c119 : 1
stoichiometry:c18 : 1
m14*m183*0.1
nodelay
--
0
PMID: 18086373, 11960013, 9734363,10882101 Activated IRAK-1 further recruits TNF-receptor-associated factor (TRAF)-6, which activates the transforming growth factor -¦Â-activated kinase (TAK)-1/TAK1-binding protein (TAB)-2 complex as well as MAP-kinases. PMID: 18086373, 16951688 Recently, Smad6 was identified to abrogate TLR signaling by complex formation with Pelle-interacting protein (Pellino), IRAK-1 and TRAF6.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c20 : 1
stoichiometry:c122 : 1
stoichiometry:c21 : 1
m16*m64*0.1
nodelay
--
0
PMID: 18086373, 11960013, 9734363,10882101 Activated IRAK-1 further recruits TNF-receptor-associated factor (TRAF)-6, which activates the transforming growth factor -¦Â-activated kinase (TAK)-1/TAK1-binding protein (TAB)-2 complex as well as MAP-kinases.
p8
p8
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c24 : 1
stoichiometry:c23 : 1
m69*m17*0.1
nodelay
--
0
PMID: 18086373, 11960013, 9734363,10882101 Activated IRAK-1 further recruits TNF-receptor-associated factor (TRAF)-6, which activates the transforming growth factor -¦Â-activated kinase (TAK)-1/TAK1-binding protein (TAB)-2 complex as well as MAP-kinases.
p9
p9
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1
m17*m19*0.1
nodelay
--
0
PMID: 18086373 Finally, nuclear factor kappaB (NF-kappaB) and activator protein 1 (AP-1) transcription factors are activated resulting in the transcription of inflammatory genes.
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--