_enti_e7
_enti_e86
_enti_e8
_enti_e85
_enti_e1
_enti_e9
_enti_e70
_enti_e88
_enti_e10
_enti_e87
_enti_e3
_enti_e4
_enti_e2
_enti_e71
_enti_e68
_enti_e69
_enti_e55
_enti_e79
_enti_e6
_enti_e138
_enti_e136
_enti_e139
_enti_e59
_enti_e53
_enti_e83
_enti_e81
_enti_e5
_enti_e11
_enti_e134
_enti_e135
_enti_e133
_enti_e137
_enti_e54
_enti_e52
_enti_e50
_enti_e56
_enti_e51
_enti_e76
_enti_e77
_enti_e80
_enti_e78
_enti_e82
_enti_e132
_enti_e61
_enti_e58
_enti_e57
_enti_e73
_enti_e84
_enti_e75
_enti_e131
_enti_e62
_enti_e60
_enti_e72
_enti_e74
g3_fact_g9
g1_fact_g11
g2_fact_g10
g2_fact_g2
g2_fact_g12
g2_fact_g13
g1_fact_g14
g1_fact_g1
g2_fact_g4
g1_fact_g8
g2_fact_g6
g2_fact_g7
g1_fact_g5
g1_fact_g3
p1_propro_p1
PMID: 18086372, 14976262, 11812998, 14976261
GU-rich ssRNA sequences of viral or host origin, poly-U RNA and specific siRNA sequences are ligands for both receptors, whereas synthetic imidazoquinoline derivatives have been designed to specifically activate TLR7 or TLR8 or both receptors.
c1 cso30:c:InputProcess connector
c2 cso30:c:InputProcess connector
c3 cso30:c:OutputProcess connector
p2_propro_p2
PMID: 18086372, 14976262, 11812998, 14976261
GU-rich ssRNA sequences of viral or host origin, poly-U RNA and specific siRNA sequences are ligands for both receptors, whereas synthetic imidazoquinoline derivatives have been designed to specifically activate TLR7 or TLR8 or both receptors.
c7 cso30:c:InputProcess connector
c8 cso30:c:InputProcess connector
c9 cso30:c:OutputProcess connector
p3_propro_p3
PMID: 18086372, 14976262, 11812998, 14976261
GU-rich ssRNA sequences of viral or host origin, poly-U RNA and specific siRNA sequences are ligands for both receptors, whereas synthetic imidazoquinoline derivatives have been designed to specifically activate TLR7 or TLR8 or both receptors.
c4 cso30:c:InputProcess connector
c5 cso30:c:InputProcess connector
c6 cso30:c:OutputProcess connector
p4_propro_p4
PMID: 18086372, 15558055, 16424225
TLR3 binds double-stranded (ds) RNA which is found in dsRNA viruses, such as reovirus, or is generated during replication of single-stranded (ss) RNA viruses such as West Nile virus or respiratory syncytial virus or as a by-product of symmetrical transcription of viral DNA, for example from herpes viruses.
PMID: 18086372, 15298172, 10933707
By binding to dsRNA NS1 disguises the viral dsRNA pattern from the cytoplasmic receptors and inhibits IFN-alpha/INF-beta induction via IRF3.
c10 cso30:c:InputProcess connector
c11 cso30:c:InputProcess connector
c281 cso30:c:InputInhibitor connector
c12 cso30:c:OutputProcess connector
p5_propro_p5
PMID: 18086372
TRIF is recruited to the cytoplasmatic TIR domain of TLR3 and interacts with a set of different signaling molecules and kinases which in turn initiate activation of NFkappaB or IRF3 and IRF7 leading to type I interferon induction.
c13 cso30:c:InputProcess connector
c15 cso30:c:InputProcess connector
c14 cso30:c:OutputProcess connector
p6_propro_p6
PMID: 18086372, 14976262, 11812998, 14976261
GU-rich ssRNA sequences of viral or host origin, poly-U RNA and specific siRNA sequences are ligands for both receptors, whereas synthetic imidazoquinoline derivatives have been designed to specifically activate TLR7 or TLR8 or both receptors.
c16 cso30:c:InputProcess connector
c17 cso30:c:InputProcess connector
c18 cso30:c:OutputProcess connector
p7_propro_p7
PMID: 18086372, 14976262, 11812998, 14976261
GU-rich ssRNA sequences of viral or host origin, poly-U RNA and specific siRNA sequences are ligands for both receptors, whereas synthetic imidazoquinoline derivatives have been designed to specifically activate TLR7 or TLR8 or both receptors.
c19 cso30:c:InputProcess connector
c20 cso30:c:InputProcess connector
c21 cso30:c:OutputProcess connector
p8_propro_p8
PMID: 18086372, 14976262, 11812998, 14976261
GU-rich ssRNA sequences of viral or host origin, poly-U RNA and specific siRNA sequences are ligands for both receptors, whereas synthetic imidazoquinoline derivatives have been designed to specifically activate TLR7 or TLR8 or both receptors.
c22 cso30:c:InputProcess connector
c23 cso30:c:InputProcess connector
c24 cso30:c:OutputProcess connector
p9_propro_p9
PMID: 18086372, 14976262, 11812998, 14976261
GU-rich ssRNA sequences of viral or host origin, poly-U RNA and specific siRNA sequences are ligands for both receptors, whereas synthetic imidazoquinoline derivatives have been designed to specifically activate TLR7 or TLR8 or both receptors.
c25 cso30:c:InputProcess connector
c26 cso30:c:InputProcess connector
c27 cso30:c:OutputProcess connector
p10_propro_p10
PMID: 18086372, 14976262, 11812998, 14976261
GU-rich ssRNA sequences of viral or host origin, poly-U RNA and specific siRNA sequences are ligands for both receptors, whereas synthetic imidazoquinoline derivatives have been designed to specifically activate TLR7 or TLR8 or both receptors.
c28 cso30:c:InputProcess connector
c30 cso30:c:InputProcess connector
c32 cso30:c:OutputProcess connector
p11_propro_p11
PMID: 18086372, 14976262, 11812998, 14976261
GU-rich ssRNA sequences of viral or host origin, poly-U RNA and specific siRNA sequences are ligands for both receptors, whereas synthetic imidazoquinoline derivatives have been designed to specifically activate TLR7 or TLR8 or both receptors.
c29 cso30:c:InputProcess connector
c31 cso30:c:InputProcess connector
c33 cso30:c:OutputProcess connector
p12_propro_p12
PMID: 18086372, 11607032
Another ligand for TLR3 is poly(I:C) which is a synthetic dsRNA mimicking viral infection.
c35 cso30:c:InputProcess connector
c34 cso30:c:InputProcess connector
c36 cso30:c:OutputProcess connector
p13_propro_p13
PMID: 18086372
Up-regulation of TLR3 expression by type I IFN amplifies the response to TLR3 ligands.
c37 cso30:c:InputAssociation connector
c38 cso30:c:OutputProcess connector
p14_propro_p14
PMID: 18086372, 12692549, 12702806, 12855817
Interaction of TRIF with TRAF3 allows complex formation with the non-canonical IKKs-TBK1 and IKK-epsilon leading to the activation of IRF3 and IRF7, which form homo- or heterodimers upon phosphorylation and are then translocated to the nucleus to induce type I IFN and IFN inducible gene expression.
c39 cso30:c:InputProcess connector
c40 cso30:c:InputProcess connector
c41 cso30:c:OutputProcess connector
p15_propro_p15
PMID: 18086372, 12692549, 12702806, 12855817
Interaction of TRIF with TRAF3 allows complex formation with the non-canonical IKKs-TBK1 and IKK-epsilon leading to the activation of IRF3 and IRF7, which form homo- or heterodimers upon phosphorylation and are then translocated to the nucleus to induce type I IFN and IFN inducible gene expression.
c42 cso30:c:InputProcess connector
c43 cso30:c:InputProcess connector
c45 cso30:c:InputProcess connector
c44 cso30:c:OutputProcess connector
p16_propro_p16
PMID: 18086372, 12692549, 12702806, 12855817
Interaction of TRIF with TRAF3 allows complex formation with the non-canonical IKKs-TBK1 and IKK-epsilon leading to the activation of IRF3 and IRF7, which form homo- or heterodimers upon phosphorylation and are then translocated to the nucleus to induce type I IFN and IFN inducible gene expression.
c46 cso30:c:InputProcess connector
c50 cso30:c:InputAssociation connector
c47 cso30:c:OutputProcess connector
p17_propro_p17
PMID: 18086372, 12692549, 12702806, 12855817
Interaction of TRIF with TRAF3 allows complex formation with the non-canonical IKKs-TBK1 and IKK-epsilon leading to the activation of IRF3 and IRF7, which form homo- or heterodimers upon phosphorylation and are then translocated to the nucleus to induce type I IFN and IFN inducible gene expression.
PMID: 18086372, 12885884
Two viral proteins of RSV, NS1 and NS2, are involved in blocking the pathway leading to IRF3 phosphorylation, although the activation of NFkappaB and AP-1 is unaffected.
c48 cso30:c:InputProcess connector
c51 cso30:c:InputAssociation connector
c282 cso30:c:InputInhibitor connector
c285 cso30:c:InputInhibitor connector
c49 cso30:c:OutputProcess connector
p18_propro_p18
PMID: 18086372, 12692549, 12702806, 12855817
Interaction of TRIF with TRAF3 allows complex formation with the non-canonical IKKs-TBK1 and IKK-epsilon leading to the activation of IRF3 and IRF7, which form homo- or heterodimers upon phosphorylation and are then translocated to the nucleus to induce type I IFN and IFN inducible gene expression.
c52 cso30:c:InputProcess connector
c53 cso30:c:OutputProcess connector
p19_propro_p19
PMID: 18086372, 12692549, 12702806, 12855817
Interaction of TRIF with TRAF3 allows complex formation with the non-canonical IKKs-TBK1 and IKK-epsilon leading to the activation of IRF3 and IRF7, which form homo- or heterodimers upon phosphorylation and are then translocated to the nucleus to induce type I IFN and IFN inducible gene expression.
c54 cso30:c:InputProcess connector
c55 cso30:c:OutputProcess connector
p20_propro_p20
PMID: 18086372, 12692549, 12702806, 12855817
Interaction of TRIF with TRAF3 allows complex formation with the non-canonical IKKs-TBK1 and IKK-epsilon leading to the activation of IRF3 and IRF7, which form homo- or heterodimers upon phosphorylation and are then translocated to the nucleus to induce type I IFN and IFN inducible gene expression.
PMID: 18086372, 16127453
This receptoradapter interaction results in the activation of the noncanonical kinases TBK1/IKK-epsilon, which in turn induces dimerization of phosphorylated IRF3 and IRF7 and translocation to the nucleus where they activate the transcription of type I IFN genes.
c56 cso30:c:InputProcess connector
c57 cso30:c:InputProcess connector
c58 cso30:c:OutputProcess connector
p21_propro_p21
PMID: 18086372, 12692549, 12702806, 12855817
Interaction of TRIF with TRAF3 allows complex formation with the non-canonical IKKs-TBK1 and IKK-epsilon leading to the activation of IRF3 and IRF7, which form homo- or heterodimers upon phosphorylation and are then translocated to the nucleus to induce type I IFN and IFN inducible gene expression.
c59 cso30:c:InputProcess connector
c60 cso30:c:OutputProcess connector
p22_propro_p22
PMID: 18086372, 12692549, 12702806, 12855817
Interaction of TRIF with TRAF3 allows complex formation with the non-canonical IKKs-TBK1 and IKK-epsilon leading to the activation of IRF3 and IRF7, which form homo- or heterodimers upon phosphorylation and are then translocated to the nucleus to induce type I IFN and IFN inducible gene expression.
PMID: 18086372, 16127453
This receptoradapter interaction results in the activation of the noncanonical kinases TBK1/IKK-epsilon, which in turn induces dimerization of phosphorylated IRF3 and IRF7 and translocation to the nucleus where they activate the transcription of type I IFN genes.
c61 cso30:c:InputProcess connector
c62 cso30:c:OutputProcess connector
p23_propro_p23
PMID: 18086372, 12692549, 12702806, 12855817
Interaction of TRIF with TRAF3 allows complex formation with the non-canonical IKKs-TBK1 and IKK-epsilon leading to the activation of IRF3 and IRF7, which form homo- or heterodimers upon phosphorylation and are then translocated to the nucleus to induce type I IFN and IFN inducible gene expression.
c63 cso30:c:InputProcess connector
c64 cso30:c:OutputProcess connector
p24_propro_p24
PMID: 18086372
NFkappaB activation by TLR3 ligands is mediated in two ways via association of TRIF with RIP1 or via interaction of TRIF with TRAF6, which in turn activates TAK1.
c65 cso30:c:InputProcess connector
c66 cso30:c:InputProcess connector
c67 cso30:c:OutputProcess connector
p25_propro_p25
PMID: 18086372
NFkappaB activation by TLR3 ligands is mediated in two ways via association of TRIF with RIP1 or via interaction of TRIF with TRAF6, which in turn activates TAK1.
c68 cso30:c:InputProcess connector
c69 cso30:c:InputProcess connector
c70 cso30:c:OutputProcess connector
p26_propro_p26
PMID: 18086372
NFkappaB activation by TLR3 ligands is mediated in two ways via association of TRIF with RIP1 or via interaction of TRIF with TRAF6, which in turn activates TAK1.
c71 cso30:c:InputAssociation connector
c72 cso30:c:InputProcess connector
c73 cso30:c:OutputProcess connector
p27_propro_p27
PMID: 18086372, 15064760, 14530355
Both RIP1 and TAK1 mediate activation of canonical IKKs (IKKalpha, IKKbeta) resulting in IkappaB degradation and NFkappaB translocation to the nucleus.
c74 cso30:c:InputAssociation connector
c76 cso30:c:InputProcess connector
c77 cso30:c:OutputProcess connector
p28_propro_p28
PMID: 18086372, 15064760, 14530355
Both RIP1 and TAK1 mediate activation of canonical IKKs (IKKalpha, IKKbeta) resulting in IkappaB degradation and NFkappaB translocation to the nucleus.
c75 cso30:c:InputAssociation connector
c78 cso30:c:InputProcess connector
c79 cso30:c:OutputProcess connector
p29_propro_p29
PMID: 18086372, 15064760, 14530355
Both RIP1 and TAK1 mediate activation of canonical IKKs (IKKalpha, IKKbeta) resulting in IkappaB degradation and NFkappaB translocation to the nucleus.
PMID: 18086372
Another branch of IPS-1 signaling leads to the activation of the IKK complex resulting in activation of NFkappaB that controls the expression of genes encoding inflammatory responses, but also expression of IFN-beta.
PMID: 18086372
Like RIG-I, MDA5 interacts with the adapter protein IPS-1 upon ligand binding leading to activation of protein kinases that subsequently activate transcription factors IRF3, IRF7 and NFkappaB, respectively.
c80 cso30:c:InputAssociation connector
c83 cso30:c:InputProcess connector
c81 cso30:c:OutputProcess connector
c82 cso30:c:OutputProcess connector
p30_propro_p30
PMID: 18086372, 15064760, 14530355
Both RIP1 and TAK1 mediate activation of canonical IKKs (IKKalpha, IKKbeta) resulting in IkappaB degradation and NFkappaB translocation to the nucleus.
PMID: 18086372
Another branch of IPS-1 signaling leads to the activation of the IKK complex resulting in activation of NFkappaB that controls the expression of genes encoding inflammatory responses, but also expression of IFN-beta.
c84 cso30:c:InputProcess connector
c85 cso30:c:OutputProcess connector
p31_propro_p31
PMID: 18086372, 12692549, 12702806, 12855817
Interaction of TRIF with TRAF3 allows complex formation with the non-canonical IKKs-TBK1 and IKK-epsilon leading to the activation of IRF3 and IRF7, which form homo- or heterodimers upon phosphorylation and are then translocated to the nucleus to induce type I IFN and IFN inducible gene expression.
c86 cso30:c:InputProcess connector
c89 cso30:c:OutputProcess connector
p32_propro_p32
PMID: 18086372, 12692549, 12702806, 12855817
Interaction of TRIF with TRAF3 allows complex formation with the non-canonical IKKs-TBK1 and IKK-epsilon leading to the activation of IRF3 and IRF7, which form homo- or heterodimers upon phosphorylation and are then translocated to the nucleus to induce type I IFN and IFN inducible gene expression.
PMID: 18086372, 16127453
This receptoradapter interaction results in the activation of the noncanonical kinases TBK1/IKK-epsilon, which in turn induces dimerization of phosphorylated IRF3 and IRF7 and translocation to the nucleus where they activate the transcription of type I IFN genes.
c87 cso30:c:InputProcess connector
c90 cso30:c:OutputProcess connector
p33_propro_p33
PMID: 18086372, 12692549, 12702806, 12855817
Interaction of TRIF with TRAF3 allows complex formation with the non-canonical IKKs-TBK1 and IKK-epsilon leading to the activation of IRF3 and IRF7, which form homo- or heterodimers upon phosphorylation and are then translocated to the nucleus to induce type I IFN and IFN inducible gene expression.
c88 cso30:c:InputProcess connector
c91 cso30:c:OutputProcess connector
p34_propro_p34
PMID: 18086372, 12692549, 12702806, 12855817
Interaction of TRIF with TRAF3 allows complex formation with the non-canonical IKKs-TBK1 and IKK-epsilon leading to the activation of IRF3 and IRF7, which form homo- or heterodimers upon phosphorylation and are then translocated to the nucleus to induce type I IFN and IFN inducible gene expression.
c92 cso30:c:InputAssociation connector
c95 cso30:c:OutputProcess connector
p35_propro_p35
PMID: 18086372, 12692549, 12702806, 12855817
Interaction of TRIF with TRAF3 allows complex formation with the non-canonical IKKs-TBK1 and IKK-epsilon leading to the activation of IRF3 and IRF7, which form homo- or heterodimers upon phosphorylation and are then translocated to the nucleus to induce type I IFN and IFN inducible gene expression.
c93 cso30:c:InputAssociation connector
c96 cso30:c:OutputProcess connector
p36_propro_p36
PMID: 18086372, 12692549, 12702806, 12855817
Interaction of TRIF with TRAF3 allows complex formation with the non-canonical IKKs-TBK1 and IKK-epsilon leading to the activation of IRF3 and IRF7, which form homo- or heterodimers upon phosphorylation and are then translocated to the nucleus to induce type I IFN and IFN inducible gene expression.
c94 cso30:c:InputAssociation connector
c97 cso30:c:OutputProcess connector
p37_propro_p37
PMID: 18086372, 17339430
Interestingly, human lung epithelial cells express proinflammatory cytokines including IL-6 and IL-8 upon infection with influenza A virus in a TLR3-dependent manner , suggesting that TLR3-mediated inflammatory responses may also contribute to influenza virus-induced lung pathology in humans.
c98 cso30:c:InputAssociation connector
c100 cso30:c:OutputProcess connector
p38_propro_p38
PMID: 18086372, 17339430
Interestingly, human lung epithelial cells express proinflammatory cytokines including IL-6 and IL-8 upon infection with influenza A virus in a TLR3-dependent manner , suggesting that TLR3-mediated inflammatory responses may also contribute to influenza virus-induced lung pathology in humans.
c99 cso30:c:InputAssociation connector
c101 cso30:c:OutputProcess connector
p39_propro_p39
PMID: 18086372
TLR9 has been described to recognize bacterial DNA or synthetic oligodesoxyribonucleotides (ODN) containing specific unmethylated CpG sequence motifs. These can also be found in the genome of DNA viruses.
c102 cso30:c:InputProcess connector
c103 cso30:c:InputProcess connector
c104 cso30:c:OutputProcess connector
p40_propro_p40
PMID: 18086372, 15492225, 15361868
Upon ligand binding the TIR domain of TLR9 recruits MyD88 which forms a supramolecular complex with TRAF6, IRAK1, IRAK4 and IRF7.
c105 cso30:c:InputProcess connector
c106 cso30:c:InputProcess connector
c107 cso30:c:OutputProcess connector
p41_propro_p41
PMID: 18086372, 15492225, 15361868
Upon ligand binding the TIR domain of TLR9 recruits MyD88 which forms a supramolecular complex with TRAF6, IRAK1, IRAK4 and IRF7.
c108 cso30:c:InputProcess connector
c109 cso30:c:InputProcess connector
c110 cso30:c:InputProcess connector
c111 cso30:c:InputProcess connector
c112 cso30:c:InputProcess connector
c113 cso30:c:OutputProcess connector
p42_propro_p42
PMID: 18086372, 15492225, 15361868
Upon ligand binding the TIR domain of TLR9 recruits MyD88 which forms a supramolecular complex with TRAF6, IRAK1, IRAK4 and IRF7.
c114 cso30:c:InputProcess connector
c116 cso30:c:OutputProcess connector
c115 cso30:c:OutputProcess connector
p43_propro_p43
PMID: 18086372
CpG ODN class A, B and C have been designed to trigger primarily type I IFN response (A) or costimulatory molecule expression and inflammatory cytokine production (B) or both (C) in pDCs.
PMID: 18086372, 16864658
Induction of type I IFNs by TLR9 ligands in pDCs depends on retention of the ligandreceptor complex within early endosomes at a pH value between 6.2 and 5.5.
c118 cso30:c:InputAssociation connector
c117 cso30:c:OutputProcess connector
p44_propro_p44
PMID: 18086372
CpG ODN class A, B and C have been designed to trigger primarily type I IFN response (A) or costimulatory molecule expression and inflammatory cytokine production (B) or both (C) in pDCs.
PMID: 18086372, 16864658
Delivery of TLR9 ligands to late endosome with lower pH values (<4.5) impairs the induction of type I IFNs and promotes inflammatory cytokine and costimulatory molecule expression in pDCs.
c121 cso30:c:InputAssociation connector
c119 cso30:c:OutputProcess connector
p45_propro_p45
PMID: 18086372
CpG ODN class A, B and C have been designed to trigger primarily type I IFN response (A) or costimulatory molecule expression and inflammatory cytokine production (B) or both (C) in pDCs.
PMID: 18086372, 16864658
Delivery of TLR9 ligands to late endosome with lower pH values (<4.5) impairs the induction of type I IFNs and promotes inflammatory cytokine and costimulatory molecule expression in pDCs.
c122 cso30:c:InputAssociation connector
c120 cso30:c:OutputProcess connector
p46_propro_p46
PMID: 18086372
During the second phase secreted type I IFNs signal via type I IFN receptor in an autocrine and paracrine manner.
c124 cso30:c:InputAssociation connector
c123 cso30:c:OutputProcess connector
p47_propro_p47
PMID: 18086372
During the second phase secreted type I IFNs signal via type I IFN receptor in an autocrine and paracrine manner.
c125 cso30:c:InputProcess connector
c126 cso30:c:InputProcess connector
c127 cso30:c:OutputProcess connector
p48_propro_p48
PMID: 18086372
Downstream signaling of the type I IFN receptor induces a strong up-regulation of IRF7 production leading to full expression of type I IFN genes (positive feedback loop).
c128 cso30:c:InputAssociation connector
c129 cso30:c:InputAssociation connector
c130 cso30:c:OutputProcess connector
p49_propro_p49
PMID: 18086372, 17018642, 17273999
In myeloid DCs IRF1 plays a crucial role in the downstream signaling of TLR9. IRF1/ mice show an impaired induction of IFN-beta, iNOS and IL-12p35 upon stimulation with TLR9 ligand CpG-B, whereas type I interferon response of pDCs is not affected by lack of IRF1.
c132 cso30:c:InputProcess connector
c131 cso30:c:InputAssociation connector
c133 cso30:c:OutputProcess connector
p50_propro_p50
PMID: 18086372, 17018642, 17273999
In myeloid DCs IRF1 plays a crucial role in the downstream signaling of TLR9. IRF1/ mice show an impaired induction of IFN-beta, iNOS and IL-12p35 upon stimulation with TLR9 ligand CpG-B, whereas type I interferon response of pDCs is not affected by lack of IRF1.
c137 cso30:c:InputAssociation connector
c134 cso30:c:OutputProcess connector
p51_propro_p51
PMID: 18086372, 17018642, 17273999
In myeloid DCs IRF1 plays a crucial role in the downstream signaling of TLR9. IRF1/ mice show an impaired induction of IFN-beta, iNOS and IL-12p35 upon stimulation with TLR9 ligand CpG-B, whereas type I interferon response of pDCs is not affected by lack of IRF1.
c138 cso30:c:InputAssociation connector
c135 cso30:c:OutputProcess connector
p52_propro_p52
PMID: 18086372, 17018642, 17273999
In myeloid DCs IRF1 plays a crucial role in the downstream signaling of TLR9. IRF1/ mice show an impaired induction of IFN-beta, iNOS and IL-12p35 upon stimulation with TLR9 ligand CpG-B, whereas type I interferon response of pDCs is not affected by lack of IRF1.
c139 cso30:c:InputAssociation connector
c136 cso30:c:OutputProcess connector
p53_propro_p53
PMID: 18086372
In the very early phase of systemic MCMV infection pDCs and conventional DCs release the first wave of type I interferons and inflammatory cytokines including IL-12.
c141 cso30:c:InputAssociation connector
c142 cso30:c:InputAssociation connector
c140 cso30:c:OutputProcess connector
p54_propro_p54
PMID: 18086372, 8557990
Control of viral replication and clearance of the virus from infected organs during the first week of MCMV infection relies mostly on NK cells, which produce IFN-gamma (mediated by IL-12 and IL-18) and kill infected cells.
c143 cso30:c:InputProcess connector
c144 cso30:c:InputProcess connector
c145 cso30:c:OutputProcess connector
p55_propro_p55
PMID: 18086372, 8557990
Control of viral replication and clearance of the virus from infected organs during the first week of MCMV infection relies mostly on NK cells, which produce IFN-gamma (mediated by IL-12 and IL-18) and kill infected cells.
c150 cso30:c:InputAssociation connector
c146 cso30:c:OutputProcess connector
p56_propro_p56
PMID: 18086372, 8557990
Control of viral replication and clearance of the virus from infected organs during the first week of MCMV infection relies mostly on NK cells, which produce IFN-gamma (mediated by IL-12 and IL-18) and kill infected cells.
c151 cso30:c:InputAssociation connector
c154 cso30:c:InputAssociation connector
c155 cso30:c:OutputProcess connector
p57_propro_p57
PMID: 18086372, 8557990
Control of viral replication and clearance of the virus from infected organs during the first week of MCMV infection relies mostly on NK cells, which produce IFN-gamma (mediated by IL-12 and IL-18) and kill infected cells.
c147 cso30:c:InputProcess connector
c148 cso30:c:InputProcess connector
c149 cso30:c:OutputProcess connector
p58_propro_p58
PMID: 18086372, 8557990
Control of viral replication and clearance of the virus from infected organs during the first week of MCMV infection relies mostly on NK cells, which produce IFN-gamma (mediated by IL-12 and IL-18) and kill infected cells.
c152 cso30:c:InputAssociation connector
c153 cso30:c:InputAssociation connector
c156 cso30:c:OutputProcess connector
p59_propro_p59
PMID: 18086372, 8557990
Control of viral replication and clearance of the virus from infected organs during the first week of MCMV infection relies mostly on NK cells, which produce IFN-gamma (mediated by IL-12 and IL-18) and kill infected cells.
c157 cso30:c:InputAssociation connector
p60_propro_p60
PMID: 18086372
The MyD88-dependent signal transduction pathway downstream of TLR7 and 8 is very similar to TLR9-mediated signaling.
c158 cso30:c:InputProcess connector
c159 cso30:c:InputProcess connector
c160 cso30:c:OutputProcess connector
p61_propro_p61
PMID: 18086372
The MyD88-dependent signal transduction pathway downstream of TLR7 and 8 is very similar to TLR9-mediated signaling.
c161 cso30:c:InputProcess connector
c162 cso30:c:InputProcess connector
c163 cso30:c:InputProcess connector
c164 cso30:c:InputProcess connector
c165 cso30:c:OutputProcess connector
p62_propro_p62
PMID: 18086372
The MyD88-dependent signal transduction pathway downstream of TLR7 and 8 is very similar to TLR9-mediated signaling.
c166 cso30:c:InputProcess connector
c167 cso30:c:OutputProcess connector
c168 cso30:c:OutputProcess connector
p63_propro_p63
PMID: 18086372
The MyD88-dependent signal transduction pathway downstream of TLR7 and 8 is very similar to TLR9-mediated signaling.
c169 cso30:c:InputProcess connector
c170 cso30:c:InputProcess connector
c171 cso30:c:OutputProcess connector
p64_propro_p64
PMID: 18086372
The MyD88-dependent signal transduction pathway downstream of TLR7 and 8 is very similar to TLR9-mediated signaling.
c172 cso30:c:InputProcess connector
c173 cso30:c:InputProcess connector
c174 cso30:c:InputProcess connector
c175 cso30:c:InputProcess connector
c176 cso30:c:InputProcess connector
c177 cso30:c:OutputProcess connector
p65_propro_p65
PMID: 18086372
The MyD88-dependent signal transduction pathway downstream of TLR7 and 8 is very similar to TLR9-mediated signaling.
c178 cso30:c:InputProcess connector
c179 cso30:c:OutputProcess connector
c180 cso30:c:OutputProcess connector
p66_propro_p66
PMID: 18086372
In addition to the TLRs, a new family of viral pattern recognition receptors consisting of RNA helicases retinoic acid inducible gene I (RIG-I), melanoma differentiation antigen 5 (MDA5) and laboratory of genetics and physiology 2 (LGP2) was discovered and characterized in the last 3 years.
PMID: 18086372, 17190814
Saito et al. also identified an analogous RD within the C terminus of LGP2 suggesting that LGP2 might inhibit RIG-I through their RD interactions.
PMID: 18086372, 15298172, 10933707
By binding to dsRNA NS1 disguises the viral dsRNA pattern from the cytoplasmic receptors and inhibits IFN-alpha/INF-beta induction via IRF3.
c181 cso30:c:InputProcess connector
c183 cso30:c:InputProcess connector
c202 cso30:c:InputInhibitor connector
c278 cso30:c:InputInhibitor connector
c185 cso30:c:OutputProcess connector
p67_propro_p67
PMID: 18086372
In addition to the TLRs, a new family of viral pattern recognition receptors consisting of RNA helicases retinoic acid inducible gene I (RIG-I), melanoma differentiation antigen 5 (MDA5) and laboratory of genetics and physiology 2 (LGP2) was discovered and characterized in the last 3 years.
PMID: 18086372, 15298172, 10933707
By binding to dsRNA NS1 disguises the viral dsRNA pattern from the cytoplasmic receptors and inhibits IFN-alpha/INF-beta induction via IRF3.
PMID: 18086372, 15563593, 17049367
The V proteins of this diverse group of viruses bind MDA5 via their highly conserved cysteine-rich C-terminal domain.This suggests that paramyxoviruses use this interaction to reduce the amount of IFN released by infected cells.
c182 cso30:c:InputProcess connector
c184 cso30:c:InputProcess connector
c279 cso30:c:InputInhibitor connector
c293 cso30:c:InputInhibitor connector
c186 cso30:c:OutputProcess connector
p68_propro_p68
PMID: 18086372
In addition to the TLRs, a new family of viral pattern recognition receptors consisting of RNA helicases retinoic acid inducible gene I (RIG-I), melanoma differentiation antigen 5 (MDA5) and laboratory of genetics and physiology 2 (LGP2) was discovered and characterized in the last 3 years.
PMID: 18086372, 16116171
LGP2 is a close relative of RIG-I, which lacks the CARDs, but is capable of binding dsRNA.
PMID: 18086372, 15298172, 10933707
By binding to dsRNA NS1 disguises the viral dsRNA pattern from the cytoplasmic receptors and inhibits IFN-alpha/INF-beta induction via IRF3.
c187 cso30:c:InputProcess connector
c188 cso30:c:InputProcess connector
c280 cso30:c:InputInhibitor connector
c189 cso30:c:OutputProcess connector
p69_propro_p69
PMID: 18086372
The binding of dsRNA to the helicase domain of RIG-I likely induces a conformational change that exposes the N-terminal CARD domains to recruit its signaling adaptor IPS-1.
PMID: 18086372, 16301520, 16177806
Hepatitis C virus (HCV) encodes the protease NS3/4A which targets IPS-1 by cleaving it at position Cys-508, thereby dislocating it from the mitochondrial membrane and thus abrogating further downstream signaling to type I IFN and NFkappaB-dependent target gene expression.
c197 cso30:c:InputProcess connector
c196 cso30:c:InputProcess connector
c301 cso30:c:InputInhibitor connector
c198 cso30:c:OutputProcess connector
p70_propro_p70
PMID: 18086372
These molecules, which are localized in the cytosol, bind specific RNA molecules derived from the genome of different RNA viruses and, with the exception of LGP2 which does not signal itself, trigger a signaling cascade leading to the production of type I IFNs and of proinflammatory cytokines in response to viral infection.
c190 cso30:c:InputAssociation connector
c192 cso30:c:InputAssociation connector
c191 cso30:c:OutputProcess connector
p71_propro_p71
PMID: 18086372
These molecules, which are localized in the cytosol, bind specific RNA molecules derived from the genome of different RNA viruses and, with the exception of LGP2 which does not signal itself, trigger a signaling cascade leading to the production of type I IFNs and of proinflammatory cytokines in response to viral infection.
c193 cso30:c:InputAssociation connector
c195 cso30:c:InputAssociation connector
c194 cso30:c:OutputProcess connector
p72_propro_p72
PMID: 18086372, 17190814
Saito et al. also identified an analogous RD within the C terminus of LGP2 suggesting that LGP2 might inhibit RIG-I through their RD interactions.
c199 cso30:c:InputProcess connector
c200 cso30:c:InputProcess connector
c201 cso30:c:OutputProcess connector
p75_propro_p75
PMID: 18086372, 16153868
Coimmunoprecipitation experiments suggest that IPS-1 interacts with TBK1 and recruits endogenous IRF3 in a virus-inducible manner.
PMID: 18086372, 17079289
Furthermore, it was observed that NS1 colocalizes with RIG-I (Mibayashi et al., 2007), suggesting that NS1 forms a complex with RIG-I and IPS-1 during viral infection, resulting in inhibition of further downstream signaling.
c210 cso30:c:InputProcess connector
c211 cso30:c:InputProcess connector
c277 cso30:c:InputInhibitor connector
c212 cso30:c:OutputProcess connector
p73_propro_p73
PMID: 18086372, 16153868
Coimmunoprecipitation experiments suggest that IPS-1 interacts with TBK1 and recruits endogenous IRF3 in a virus-inducible manner.
c203 cso30:c:InputProcess connector
c204 cso30:c:InputProcess connector
c205 cso30:c:OutputProcess connector
p76_propro_p76
PMID: 18086372, 16127453
This receptoradapter interaction results in the activation of the noncanonical kinases TBK1/IKK-epsilon, which in turn induces dimerization of phosphorylated IRF3 and IRF7 and translocation to the nucleus where they activate the transcription of type I IFN genes.
PMID: 18086372, 12885884
Two viral proteins of RSV, NS1 and NS2, are involved in blocking the pathway leading to IRF3 phosphorylation, although the activation of NFkappaB and AP-1 is unaffected.
PMID: 18086372, 15919920
IRF3 phosphorylation by TBK1 was identified as target of the Rabies virus phosphoprotein P.
c209 cso30:c:InputProcess connector
c284 cso30:c:InputInhibitor connector
c287 cso30:c:InputInhibitor connector
c288 cso30:c:InputInhibitor connector
c213 cso30:c:OutputProcess connector
c214 cso30:c:OutputProcess connector
p74_propro_p74
PMID: 18086372, 16858409
Recently, TRAF3 was shown to be critically involved in IPS-1-mediated IFN-alpha production and antiviral responses through a direct interaction between the TRAF domain of TRAF3 and a TRAF interaction motif within IPS-1.
c206 cso30:c:InputProcess connector
c207 cso30:c:InputProcess connector
c208 cso30:c:OutputProcess connector
p77_propro_p77
PMID: 18086372, 16858409
Recently, TRAF3 was shown to be critically involved in IPS-1-mediated IFN-alpha production and antiviral responses through a direct interaction between the TRAF domain of TRAF3 and a TRAF interaction motif within IPS-1.
c216 cso30:c:InputAssociation connector
c217 cso30:c:InputAssociation connector
c215 cso30:c:OutputProcess connector
p78_propro_p78
PMID: 18086372, 15549108
RIP1 and FADD are additional molecules that have been reported to be required for type I IFN production in response to dsRNA.
c218 cso30:c:InputProcess connector
c219 cso30:c:InputProcess connector
c220 cso30:c:InputProcess connector
c221 cso30:c:OutputProcess connector
p79_propro_p79
PMID: 18086372, 15549108
RIP1 and FADD are additional molecules that have been reported to be required for type I IFN production in response to dsRNA.
c222 cso30:c:InputAssociation connector
c224 cso30:c:InputAssociation connector
c223 cso30:c:OutputProcess connector
p80_propro_p80
PMID: 18086372, 17327220
There is evidence that the TBK1/IKK-epsilon adaptor protein TANK plays a role in IPS-1-TRAF3-mediated activation of TBK1/IKK-epsilon.
c225 cso30:c:InputProcess connector
c227 cso30:c:InputAssociation connector
c228 cso30:c:InputAssociation connector
c226 cso30:c:OutputProcess connector
p81_propro_p81
PMID: 18086372, 16125763, 16153868
IPS-1 binds to TRAF6 upon overexpression in mammalian cells and in a yeast-two hybrid screen reported that endogenous IPS-1 also interacts with TRAF6.
c229 cso30:c:InputProcess connector
c230 cso30:c:InputProcess connector
c231 cso30:c:OutputProcess connector
p82_propro_p82
PMID: 18086372
Another branch of IPS-1 signaling leads to the activation of the IKK complex resulting in activation of NFkappaB that controls the expression of genes encoding inflammatory responses, but also expression of IFN-beta.
c232 cso30:c:InputProcess connector
c234 cso30:c:InputAssociation connector
c233 cso30:c:OutputProcess connector
p83_propro_p83
PMID: 18086372
Another branch of IPS-1 signaling leads to the activation of the IKK complex resulting in activation of NFkappaB that controls the expression of genes encoding inflammatory responses, but also expression of IFN-beta.
c236 cso30:c:InputAssociation connector
c235 cso30:c:OutputProcess connector
p84_propro_p84
PMID: 18086372, 17038590
Taken together, the results of Hornung et al.(2006) show that RIG-I directly recognizes 5′-triphosphate single stranded or double stranded RNA independently of viral replication.
c237 cso30:c:InputProcess connector
c238 cso30:c:InputProcess connector
c239 cso30:c:OutputProcess connector
p85_propro_p85
PMID: 18086372, 12015121
It was reported in a previous publication, that MDA5, which was then called Helicard, is cleaved by caspases upon induction of apoptosis, thereby separating the CARD domains from the C-terminal helicase domain, which localizes to the nucleus where it is involved in DNA degradation and nuclear remodelling during apoptotic cell death.
c240 cso30:c:InputProcess connector
c243 cso30:c:InputAssociation connector
c241 cso30:c:OutputProcess connector
c242 cso30:c:OutputProcess connector
p86_propro_p86
PMID: 18086372, 12015121
It was reported in a previous publication, that MDA5, which was then called Helicard, is cleaved by caspases upon induction of apoptosis, thereby separating the CARD domains from the C-terminal helicase domain, which localizes to the nucleus where it is involved in DNA degradation and nuclear remodelling during apoptotic cell death.
c244 cso30:c:InputProcess connector
c245 cso30:c:OutputProcess connector
p89_propro_p89
PMID: 18086372, 12015121
It was reported in a previous publication, that MDA5, which was then called Helicard, is cleaved by caspases upon induction of apoptosis, thereby separating the CARD domains from the C-terminal helicase domain, which localizes to the nucleus where it is involved in DNA degradation and nuclear remodelling during apoptotic cell death.
c246 cso30:c:InputAssociation connector
p87_propro_p87
PMID: 18086372
MDA5 is ubiquitously expressed in low abundance and similarly to RIG-I and LGP2 its expression is induced by type I IFN.
c250 cso30:c:InputAssociation connector
c247 cso30:c:OutputProcess connector
p88_propro_p88
PMID: 18086372
MDA5 is ubiquitously expressed in low abundance and similarly to RIG-I and LGP2 its expression is induced by type I IFN.
c251 cso30:c:InputAssociation connector
c248 cso30:c:OutputProcess connector
p90_propro_p90
PMID: 18086372
MDA5 is ubiquitously expressed in low abundance and similarly to RIG-I and LGP2 its expression is induced by type I IFN.
c252 cso30:c:InputAssociation connector
c249 cso30:c:OutputProcess connector
p91_propro_p91
PMID: 18086372
Like RIG-I, MDA5 interacts with the adapter protein IPS-1 upon ligand binding leading to activation of protein kinases that subsequently activate transcription factors IRF3, IRF7 and NFkappaB, respectively.
PMID: 18086372, 16301520, 16177806
Hepatitis C virus (HCV) encodes the protease NS3/4A which targets IPS-1 by cleaving it at position Cys-508, thereby dislocating it from the mitochondrial membrane and thus abrogating further downstream signaling to type I IFN and NFkappaB-dependent target gene expression.
c253 cso30:c:InputProcess connector
c254 cso30:c:InputProcess connector
c302 cso30:c:InputInhibitor connector
c255 cso30:c:OutputProcess connector
p94_propro_p94
PMID: 18086372
Like RIG-I, MDA5 interacts with the adapter protein IPS-1 upon ligand binding leading to activation of protein kinases that subsequently activate transcription factors IRF3, IRF7 and NFkappaB, respectively.
c262 cso30:c:InputProcess connector
c264 cso30:c:InputAssociation connector
c263 cso30:c:OutputProcess connector
p92_propro_p92
PMID: 18086372
Like RIG-I, MDA5 interacts with the adapter protein IPS-1 upon ligand binding leading to activation of protein kinases that subsequently activate transcription factors IRF3, IRF7 and NFkappaB, respectively.
c256 cso30:c:InputProcess connector
c257 cso30:c:InputProcess connector
c258 cso30:c:InputProcess connector
c259 cso30:c:OutputProcess connector
p93_propro_p93
PMID: 18086372
Like RIG-I, MDA5 interacts with the adapter protein IPS-1 upon ligand binding leading to activation of protein kinases that subsequently activate transcription factors IRF3, IRF7 and NFkappaB, respectively.
c260 cso30:c:InputProcess connector
c267 cso30:c:InputAssociation connector
c261 cso30:c:OutputProcess connector
p95_propro_p95
PMID: 18086372
Like RIG-I, MDA5 interacts with the adapter protein IPS-1 upon ligand binding leading to activation of protein kinases that subsequently activate transcription factors IRF3, IRF7 and NFkappaB, respectively.
PMID: 18086372, 12885884
Two viral proteins of RSV, NS1 and NS2, are involved in blocking the pathway leading to IRF3 phosphorylation, although the activation of NFkappaB and AP-1 is unaffected.
PMID: 18086372, 15919920
IRF3 phosphorylation by TBK1 was identified as target of the Rabies virus phosphoprotein P.
c265 cso30:c:InputProcess connector
c268 cso30:c:InputAssociation connector
c283 cso30:c:InputInhibitor connector
c286 cso30:c:InputInhibitor connector
c289 cso30:c:InputInhibitor connector
c266 cso30:c:OutputProcess connector
p96_propro_p96
PMID: 18086372
In addition, it was shown that MDA5 might also play a role in the measles virus (MV) induced activation of IFN-beta mRNA synthesis since A549 cells transfected with MDA5 showed a strong activation of the IFN-beta promoter upon infection with MV.
c270 cso30:c:InputAssociation connector
c269 cso30:c:OutputProcess connector
p97_propro_p97
PMID: 18086372, 15298172, 10933707
By binding to dsRNA NS1 disguises the viral dsRNA pattern from the cytoplasmic receptors and inhibits IFN-alpha/INF-beta induction via IRF3.
c271 cso30:c:InputProcess connector
c272 cso30:c:InputProcess connector
c273 cso30:c:OutputProcess connector
p98_propro_p98
PMID: 18086372, 17079289
Furthermore, it was observed that NS1 colocalizes with RIG-I (Mibayashi et al., 2007), suggesting that NS1 forms a complex with RIG-I and IPS-1 during viral infection, resulting in inhibition of further downstream signaling.
c274 cso30:c:InputProcess connector
c275 cso30:c:InputProcess connector
c276 cso30:c:OutputProcess connector
p99_propro_p99
PMID: 18086372, 15563593, 17049367
The V proteins of this diverse group of viruses bind MDA5 via their highly conserved cysteine-rich C-terminal domain.This suggests that paramyxoviruses use this interaction to reduce the amount of IFN released by infected cells.
c290 cso30:c:InputProcess connector
c291 cso30:c:InputProcess connector
c292 cso30:c:OutputProcess connector
p100_propro_p100
PMID: 18086372
Degradation of MDA5 in poliovirus-infected cells occurs in a proteasome- and caspase-dependent manner and correlates with the induction of apoptosis in poliovirus-infected cells.
c294 cso30:c:InputAssociation connector
c295 cso30:c:InputAssociation connector
c296 cso30:c:InputProcess connector
c297 cso30:c:OutputProcess connector
p101_propro_p101
PMID: 18086372, 16301520, 16177806
Hepatitis C virus (HCV) encodes the protease NS3/4A which targets IPS-1 by cleaving it at position Cys-508, thereby dislocating it from the mitochondrial membrane and thus abrogating further downstream signaling to type I IFN and NFkappaB-dependent target gene expression.
c298 cso30:c:InputProcess connector
c299 cso30:c:InputAssociation connector
c300 cso30:c:OutputProcess connector
p102_propro_p102
PMID: 18086372
Apart from activating the NFkappaB and MAPK signaling pathways leading to inflammatory cytokine and chemokine production as well as costimulatory molecule expression, the intracellularly localized nucleic acid recognition receptors TLR3, 7, 8 and 9 specifically trigger type I interferon production via MyD88- and TRIF-dependent signaling pathways.
c303 cso30:c:InputProcess connector
c305 cso30:c:InputAssociation connector
c304 cso30:c:OutputProcess connector
p103_propro_p103
PMID: 18086372
Apart from activating the NFkappaB and MAPK signaling pathways leading to inflammatory cytokine and chemokine production as well as costimulatory molecule expression, the intracellularly localized nucleic acid recognition receptors TLR3, 7, 8 and 9 specifically trigger type I interferon production via MyD88- and TRIF-dependent signaling pathways.
c306 cso30:c:InputAssociation connector
c307 cso30:c:InputProcess connector
c308 cso30:c:OutputProcess connector
p104_propro_p104
PMID: 18086372
Apart from activating the NFkappaB and MAPK signaling pathways leading to inflammatory cytokine and chemokine production as well as costimulatory molecule expression, the intracellularly localized nucleic acid recognition receptors TLR3, 7, 8 and 9 specifically trigger type I interferon production via MyD88- and TRIF-dependent signaling pathways.
c310 cso30:c:InputAssociation connector
c311 cso30:c:InputAssociation connector
c309 cso30:c:OutputProcess connector
p105_propro_p105
PMID: 18086372
Apart from activating the NFkappaB and MAPK signaling pathways leading to inflammatory cytokine and chemokine production as well as costimulatory molecule expression, the intracellularly localized nucleic acid recognition receptors TLR3, 7, 8 and 9 specifically trigger type I interferon production via MyD88- and TRIF-dependent signaling pathways.
c312 cso30:c:InputAssociation connector
c313 cso30:c:InputAssociation connector
c314 cso30:c:OutputProcess connector
TLR3_enti_MO000019398
TLR3
dsRNA:TLR3_enti_MO000041446
dsRNA:TLR3
TLR8_enti_MO000042007
TLR8
TLR9_enti_MO000042012
TLR9
TLR7_enti_MO000042126
TLR7
IRF-7_enti_MO000007702
IRF-7
IRF-7{p}_enti_MO000041457
IRF-7{p}
MyD88_enti_MO000016573
MyD88
TRAF6_enti_MO000000212
TRAF6
IRAK_enti_MO000000213
IRAK
IRAK-4_enti_MO000039077
IRAK-4
dsRNA_enti_MO000022224
dsRNA
ssRNA_enti_e12
ssRNA
CpG DNA_enti_e13
CpG DNA
dsRNA:TLR3:TRIF_enti_MO000041437
dsRNA:TLR3:TRIF
TRIF_enti_MO000041125
TRIF
ssRNA: TLR7_enti_e14
ssRNA: TLR7
ssRNA: TLR8_enti_e15
ssRNA: TLR8
CpG DNA: TLR9_enti_e16
CpG DNA: TLR9
IRF-3_enti_MO000007694
IRF-3
IRF-3{p}_enti_MO000041456
IRF-3{p}
NF-kappaB_enti_MO000000058
NF-kappaB
TRAF3_enti_MO000016963
TRAF3
TBK1_enti_MO000019331
TBK1
dsRNA:TLR3:TRIF:TBK1:IKK-i_enti_MO000041441
dsRNA:TLR3:TRIF:TBK1:IKK-i
poly U RNA_enti_e17
poly U RNA
Poly U RNA: TLR7_enti_e18
Poly U RNA: TLR7
Poly U RNA: TLR8_enti_e19
Poly U RNA: TLR8
IKK-i_enti_MO000016608
IKK-i
IL-12_enti_MO000017265
IL-12
siRNA_enti_e20
siRNA
siRNA: TLR8_enti_e21
siRNA: TLR8
siRNA: TLR7_enti_e22
siRNA: TLR7
imidazoquinoline_enti_e23
imidazoquinoline
imidazoquinoline: TLR7_enti_e24
imidazoquinoline: TLR7
imidazoquinoline: TLR8_enti_e25
imidazoquinoline: TLR8
poly I: C: TLR3_enti_e27
poly I: C: TLR3
IFN Type I_enti_MO000016658
IFN Type I
TLR3_enti_G010963
TLR3
dsRNA:TLR3:TRIF: TRAF3_enti_e28
dsRNA:TLR3:TRIF: TRAF3
IRF-7: IRF-7{p}_enti_e29
IRF-7: IRF-7{p}
IRF-3: IRF-3{p}_enti_e30
IRF-3: IRF-3{p}
IRF-3{p}: IRF-7{p}_enti_e31
IRF-3{p}: IRF-7{p}
IRF-7: IRF-7{p}_enti_e32
IRF-7: IRF-7{p}
IRF-3{p}: IRF-7{p}_enti_e33
IRF-3{p}: IRF-7{p}
IRF-3: IRF-3{p}_enti_e34
IRF-3: IRF-3{p}
RIP1_enti_MO000000065
RIP1
dsRNA:TLR3:TRIF: RIP1_enti_e35
dsRNA:TLR3:TRIF: RIP1
dsRNA:TLR3:TRIF: TRAF6_enti_e36
dsRNA:TLR3:TRIF: TRAF6
TAK1_enti_MO000016574
TAK1
TAK1{activated}_enti_e37
TAK1{activated}
IKK-alpha:IKK-beta:IKK-gamma_enti_MO000016661
IKK-alpha:IKK-beta:IKK-gamma
IKK-alpha:IKK-beta:IKK-gamma{activated}_enti_e38
IKK-alpha:IKK-beta:IKK-gamma{activated}
IkappaB: NF-kappaB_enti_e39
IkappaB: NF-kappaB
protein remnants_enti_MO000019479
protein remnants
NF-kappaB{nuclear}_enti_e40
NF-kappaB{nuclear}
IFN Type I_enti_e41
IFN Type I
IFN inducible genes_enti_e42
IFN inducible genes
IL-6_enti_G010262
IL-6
IL-8_enti_e43
IL-8
ODN_enti_e44
ODN
ODN: TLR9_enti_e45
ODN: TLR9
CpG DNA: TLR9: MyD88_enti_e46
CpG DNA: TLR9: MyD88
CpG DNA: TLR9: MyD88: IRAk-1: IRAK-4: TRAF6: IRF-7_enti_e47
CpG DNA: TLR9: MyD88: IRAk-1: IRAK-4: TRAF6: IRF-7
CpG DNA: TLR9: MyD88: IRAk-1: IRAK-4: TRAF6_enti_e48
CpG DNA: TLR9: MyD88: IRAk-1: IRAK-4: TRAF6
cytokine_enti_e49
cytokine
costimulatory molecule genes_enti_e63
costimulatory molecule genes
IFNRs_enti_MO000016834
IFNRs
IFN Type I: IFNRs_enti_e64
IFN Type I: IFNRs
IRF-7_enti_G010713
IRF-7
IRF-1_enti_MO000007685
IRF-1
IRF-1{activated}_enti_e65
IRF-1{activated}
IFN-beta_enti_G010228
IFN-beta
iNOS_enti_G010514
iNOS
IL-12p35_enti_e66
IL-12p35
CpG-B ODN_enti_e67
CpG-B ODN
IL-12 p40_enti_G010657
IL-12 p40
IL-12R_enti_MO000033676
IL-12R
IL-12: IL-12R_enti_e89
IL-12: IL-12R
IL-8_enti_MO000017264
IL-8
IL-8 receptor_enti_e90
IL-8 receptor
IL-8: IL-8 receptor_enti_e91
IL-8: IL-8 receptor
IFN-gamma_enti_G010453
IFN-gamma
IFNgamma_enti_MO000016665
IFNgamma
ssRNA: TLR7: MyD88_enti_e92
ssRNA: TLR7: MyD88
ssRNA: TLR7: MyD88: IRAK-1: IRAk-4: TRAF6: IRF-7_enti_e93
ssRNA: TLR7: MyD88: IRAK-1: IRAk-4: TRAF6: IRF-7
ssRNA: TLR7: MyD88: IRAK-1: IRAk-4: TRAF6_enti_e94
ssRNA: TLR7: MyD88: IRAK-1: IRAk-4: TRAF6
ssRNA: TLR8: MyD88_enti_e95
ssRNA: TLR8: MyD88
ssRNA: TLR8: MyD88: IRAK-1: IRAk-4: TRAF6: IRF-7_enti_e96
ssRNA: TLR8: MyD88: IRAK-1: IRAk-4: TRAF6: IRF-7
ssRNA: TLR8: MyD88: IRAK-1: IRAk-4: TRAF6_enti_e97
ssRNA: TLR8: MyD88: IRAK-1: IRAk-4: TRAF6
MDA-5_enti_MO000103999
MDA-5
RIG-1_enti_e98
RIG-1
dsRNA: RIG-1_enti_e99
dsRNA: RIG-1
dsRNA: MDA-5_enti_e100
dsRNA: MDA-5
IPS-1_enti_MO000094908
IPS-1
LGP2_enti_e101
LGP2
dsRNA: LGP2_enti_e102
dsRNA: LGP2
cytokines_enti_MO000019387
cytokines
dsRNA: RIG-1: IPS-1_enti_e103
dsRNA: RIG-1: IPS-1
TBK1: IKK-i_enti_e104
TBK1: IKK-i
LGP2: RIG-1_enti_e105
LGP2: RIG-1
dsRNA: RIG-1: IPS-1: TBK1: IKK-i_enti_e107
dsRNA: RIG-1: IPS-1: TBK1: IKK-i
dsRNA: RIG-1: IPS-1: TBK1: IKK-i: IRF-3_enti_e108
dsRNA: RIG-1: IPS-1: TBK1: IKK-i: IRF-3
dsRNA: RIG-1: IPS-1: TRAF3_enti_e106
dsRNA: RIG-1: IPS-1: TRAF3
IFN-alpha1_enti_G016992
IFN-alpha1
IFNalpha1_enti_MO000016659
IFNalpha1
dsRNA: RIG-1: IPS-1: RIP1: FADD_enti_e109
dsRNA: RIG-1: IPS-1: RIP1: FADD
FADD_enti_MO000016899
FADD
TBK1: IKK-i{activated}_enti_e110
TBK1: IKK-i{activated}
TANK_enti_MO000019326
TANK
dsRNA: RIG-1: IPS-1: TRAF6_enti_e111
dsRNA: RIG-1: IPS-1: TRAF6
5'-triphosphate ssRNA_enti_e112
5'-triphosphate ssRNA
5'-triphosphate ssRNA: RIG-1_enti_e113
5'-triphosphate ssRNA: RIG-1
Caspases_enti_MO000016907
Caspases
card domain_enti_e114
card domain
C-terminal helicase domain_enti_e115
C-terminal helicase domain
C-terminal helicase domain_enti_e116
C-terminal helicase domain
MDA-5_enti_e117
MDA-5
RIG-1_enti_e118
RIG-1
LGP2_enti_e119
LGP2
dsRNA: MDA-5: IPS-1_enti_e120
dsRNA: MDA-5: IPS-1
dsRNA: MDA-5: IPS-1: TBK1: IKK-i_enti_e121
dsRNA: MDA-5: IPS-1: TBK1: IKK-i
NS1_enti_e122
NS1
dsRNA: NS1_enti_e123
dsRNA: NS1
dsRNA: NS1: RIG-1: IPS-1_enti_e124
dsRNA: NS1: RIG-1: IPS-1
RSV NS1_enti_e125
RSV NS1
RSV NS2_enti_e126
RSV NS2
phosphoprotein P_enti_e127
phosphoprotein P
V protein_enti_e128
V protein
V rpotein: MDA-5_enti_e129
V rpotein: MDA-5
poliovirus protin_enti_e130
poliovirus protin
NS3/4A_enti_e140
NS3/4A
e141_enti_e141
e141
ligand: TLR_enti_e142
ligand: TLR
MAPKs_enti_MO000000077
MAPKs
MAPKs{activated}_enti_e143
MAPKs{activated}
chemokines_enti_MO000000265
chemokines
chemokine_enti_e144
chemokine
poly I: C_enti_e26
poly I: C