Entity
--
e1
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane
--
--
--
csml-variable:Double
m1
0
infinite
0
--
--
e10
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytosol
--
--
--
csml-variable:Double
m10
0
infinite
0
--
TLR ligand: TLR: MyD88
--
e11
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m11
0
infinite
0
--
csml-variable:Double
m12
0
infinite
0
--
IL-12: IL-12R
--
e13
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m13
0
infinite
0
--
DLL4: Notch
--
e14
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m14
0
infinite
0
--
DLL1
--
e15
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m15
0
infinite
0
--
DLL2
--
e16
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m16
0
infinite
0
--
--
e2
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m2
0
infinite
0
--
--
e3
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
--
csml-variable:Double
m3
0
infinite
0
--
--
e4
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m4
0
infinite
0
--
csml-variable:Double
m5
0
infinite
0
--
--
e50
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelopeLumen
--
--
--
csml-variable:Double
m50
0
infinite
0
--
--
e51
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearPore
--
--
--
csml-variable:Double
m51
0
infinite
0
--
--
e52
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearInnerMembrane
--
--
--
csml-variable:Double
m52
0
infinite
0
--
--
e53
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearLumen
--
--
--
csml-variable:Double
m53
0
infinite
0
--
--
e54
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearOuterMembrane
--
--
--
csml-variable:Double
m54
0
infinite
0
--
--
e55
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleus
--
--
--
csml-variable:Double
m55
0
infinite
0
--
--
e56
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleoplasm
--
--
--
csml-variable:Double
m56
0
infinite
0
--
--
e57
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearBody
--
--
--
csml-variable:Double
m57
0
infinite
0
--
--
e58
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleolus
--
--
--
csml-variable:Double
m58
0
infinite
0
--
--
e59
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelope
--
--
--
csml-variable:Double
m59
0
infinite
0
--
TLR ligand: TLR
--
e6
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m6
0
infinite
0
--
--
e60
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Chromatin
--
--
--
csml-variable:Double
m60
0
infinite
0
--
--
e61
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearChromosome
--
--
--
csml-variable:Double
m61
0
infinite
0
--
--
e62
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearCentromere
--
--
--
csml-variable:Double
m62
0
infinite
0
--
--
e7
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell
--
--
--
csml-variable:Double
m7
0
infinite
0
--
--
e8
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell_WithoutCellWall_
--
--
--
csml-variable:Double
m8
0
infinite
0
--
--
e9
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytoplasm
--
--
--
csml-variable:Double
m9
0
infinite
0
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1
m5*m3962*0.1
nodelay
--
0
PMID: 18073395 Data suggest that TLR activation via myeloid differentiation factor 88 adaptor protein leads to the induction of a Notch ligand known as Delta-like-4 on dendritic cells that activate the Notch receptor on T cells, promoting a helper T-cell type 1 cytokine response.
p10
p10
cso30:i:ME_Binding
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1
m2121*m12340*0.1
nodelay
--
0
PMID: 18073395 It is clear that the activation of TLRs on antigen-presenting cells can lead to the expression of IL-12 and subsequently activate the expression of IFN-gamma from Th1 cells.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
m13*0.1
nodelay
--
0
PMID: 18073395 It is clear that the activation of TLRs on antigen-presenting cells can lead to the expression of IL-12 and subsequently activate the expression of IFN-gamma from Th1 cells.
p12
p12
cso30:i:ME_Translation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c28 : 1
stoichiometry:c21 : 1
m93275*m14*0.1
nodelay
--
0
PMID: 18073395 This study showed that production of both IL-5 and IL-13 from antigen-challenged lymphocytes recovered from animals treated with antibody to DL4 was enhanced over control antibody-treated animals.
p13
p13
cso30:i:ME_Translation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c24 : 1
stoichiometry:c29 : 1
stoichiometry:c22 : 1
m93493*m14*0.1
nodelay
--
0
PMID: 18073395 This study showed that production of both IL-5 and IL-13 from antigen-challenged lymphocytes recovered from animals treated with antibody to DL4 was enhanced over control antibody-treated animals.
p14
p14
cso30:i:ME_Binding
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1
m43386*m222*0.1
nodelay
--
0
PMID: 18073395 This study showed that production of both IL-5 and IL-13 from antigen-challenged lymphocytes recovered from animals treated with antibody to DL4 was enhanced over control antibody-treated animals.
p15
p15
cso30:i:CE_CellDifferentiation
cso30:i:CC_Extracellular
--
--
PMID: 18073395, 15886115 Studies suggest that the Notch ligands Delta-like-1?4 and Jagged, expressed on dendritic cells, can provide novel activation signals for the development of either Th1 and Th2 cells, respectively (67).
p16
p16
cso30:i:CE_CellDifferentiation
cso30:i:CC_Extracellular
--
--
PMID: 18073395, 15886115 Studies suggest that the Notch ligands Delta-like-1?4 and Jagged, expressed on dendritic cells, can provide novel activation signals for the development of either Th1 and Th2 cells, respectively (67).
PMID: 18073395, 15886115 Studies suggest that the Notch ligands Delta-like-1?4 and Jagged, expressed on dendritic cells, can provide novel activation signals for the development of either Th1 and Th2 cells, respectively (67).
PMID: 18073395, 15886115 Studies suggest that the Notch ligands Delta-like-1?4 and Jagged, expressed on dendritic cells, can provide novel activation signals for the development of either Th1 and Th2 cells, respectively (67).
p19
p19
cso30:i:CE_CellDifferentiation
cso30:i:CC_Extracellular
--
--
PMID: 18073395, 15886115 Studies suggest that the Notch ligands Delta-like-1?4 and Jagged, expressed on dendritic cells, can provide novel activation signals for the development of either Th1 and Th2 cells, respectively (67).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1
m6*m1572*0.1
nodelay
--
0
PMID: 18073395 Data suggest that TLR activation via myeloid differentiation factor 88 adaptor protein leads to the induction of a Notch ligand known as Delta-like-4 on dendritic cells that activate the Notch receptor on T cells, promoting a helper T-cell type 1 cytokine response.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
m11*0.1
nodelay
--
0
PMID: 18073395 Data suggest that TLR activation via myeloid differentiation factor 88 adaptor protein leads to the induction of a Notch ligand known as Delta-like-4 on dendritic cells that activate the Notch receptor on T cells, promoting a helper T-cell type 1 cytokine response.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c30 : 1
stoichiometry:c9 : 1
m6*0.1
nodelay
--
0
PMID: 18073395 For example, a pivotal role for TLR molecules in aiding the evolution of a type 1?polarized acquire immune response has been identified via the induction of IL-12 and IL-23, and the expression of both MHC class II:peptide and costimulatory molecules (CD80 and CD86).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c10 : 1
m6*0.1
nodelay
--
0
PMID: 18073395 For example, a pivotal role for TLR molecules in aiding the evolution of a type 1?polarized acquire immune response has been identified via the induction of IL-12 and IL-23, and the expression of both MHC class II:peptide and costimulatory molecules (CD80 and CD86).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c33 : 1
stoichiometry:c12 : 1
m6*0.1
nodelay
--
0
PMID: 18073395 For example, a pivotal role for TLR molecules in aiding the evolution of a type 1?polarized acquire immune response has been identified via the induction of IL-12 and IL-23, and the expression of both MHC class II:peptide and costimulatory molecules (CD80 and CD86).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1
stoichiometry:c11 : 1
m6*0.1
nodelay
--
0
PMID: 18073395 For example, a pivotal role for TLR molecules in aiding the evolution of a type 1?polarized acquire immune response has been identified via the induction of IL-12 and IL-23, and the expression of both MHC class II:peptide and costimulatory molecules (CD80 and CD86).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c13 : 1
m6*0.1
nodelay
--
0
PMID: 18073395 For example, a pivotal role for TLR molecules in aiding the evolution of a type 1?polarized acquire immune response has been identified via the induction of IL-12 and IL-23, and the expression of both MHC class II:peptide and costimulatory molecules (CD80 and CD86).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c14 : 1
m93589*0.1
nodelay
--
0
PMID: 18073395 It is clear that the activation of TLRs on antigen-presenting cells can lead to the expression of IL-12 and subsequently activate the expression of IFN-gamma from Th1 cells.
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--