Entity
Process
NF-kappaB
--
MO000000058
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m41
10
infinite
0
TRANSPATH | MO000000058 |
--
STAT1
--
MO000013119
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m1357
10
infinite
0
InterPro | IPR008967 |
TRANSPATH | MO000013119 |
--
MyD88
--
MO000016573
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m1572
10
infinite
0
InterPro | IPR000157 |
TRANSPATH | MO000016573 |
--
protein remnants
--
MO000019479
cso30:c:Protein
cso30:i:CC_CellComponent
--
--
csml-variable:Double
m360980
10
infinite
0
TRANSPATH | MO000019479 |
--
STAT1{p}
--
MO000019704
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m4238
10
infinite
0
TRANSPATH | MO000019704 |
--
dsRNA
--
MO000022224
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m119368
10
infinite
0
TRANSPATH | MO000022224 |
--
dsRNA:TLR3:TRIF
--
MO000041437
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m19305
10
infinite
0
TRANSPATH | MO000041437 |
--
dsRNA:TLR3
--
MO000041446
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m19314
10
infinite
0
TRANSPATH | MO000041446 |
--
IRF-3{p}
--
MO000041456
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m19324
10
infinite
0
TRANSPATH | MO000041456 |
--
IRF-7{p}
--
MO000041457
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m19325
10
infinite
0
TRANSPATH | MO000041457 |
--
TLR7
--
MO000042126
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m19940
10
infinite
0
TRANSPATH | MO000042126 |
--
ATF-2:c-Jun
--
MO000055971
cso30:c:Protein
cso30:i:CC_CellComponent
--
--
csml-variable:Double
m31298
10
infinite
0
TRANSPATH | MO000055971 |
--
--
e1
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane
--
--
--
csml-variable:Double
m1
0
infinite
0
--
--
e10
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytosol
--
--
--
csml-variable:Double
m10
0
infinite
0
--
CXCL11
--
e100
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m101
0
infinite
0
--
IL-12
--
e101
cso30:c:mRNA
cso30:i:CC_Cytosol
--
csml-variable:Double
m102
0
infinite
0
--
IL-12
--
e102
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m103
0
infinite
0
--
CD40
--
e103
cso30:c:Protein
cso30:i:CC_Extracellular
--
csml-variable:Double
m104
0
infinite
0
--
Stat1
--
e104
cso30:c:mRNA
cso30:i:CC_Cytosol
--
csml-variable:Double
m105
0
infinite
0
--
target genes
--
e106
cso30:c:mRNA
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m107
0
infinite
0
--
IL-1beta
--
e107
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m108
0
infinite
0
--
CD40L
--
e108
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m109
0
infinite
0
--
peptidoglycan:TLR2
--
e11
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m11
0
infinite
0
--
peptidoglycan
--
e12
cso30:c:SmallMolecule
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m12
0
infinite
0
--
lipopolypeptides
--
e13
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m13
0
infinite
0
--
lipopolypeptides:TLR2
--
e14
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m14
0
infinite
0
--
--
e15
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Endosome
--
--
--
csml-variable:Double
m15
0
infinite
0
--
--
e16
cso30:c:EntityBiologicalCompartment
cso30:i:CC_EndosomeLumen
--
--
--
csml-variable:Double
m16
0
infinite
0
--
--
e17
cso30:c:EntityBiologicalCompartment
cso30:i:CC_EndosomeMembrane
--
--
--
csml-variable:Double
m17
0
infinite
0
--
flagellin:TLR5
--
e18
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m18
0
infinite
0
--
ssRNA:TLR7
--
e19
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m19
0
infinite
0
--
--
e2
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m2
0
infinite
0
--
ssRNA
--
e20
cso30:c:Rna
cso30:i:CC_Cytosol
--
csml-variable:Double
m20
0
infinite
0
--
ssRNA:TLR8
--
e21
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m21
0
infinite
0
--
csml-variable:Double
m22
0
infinite
0
--
CpG DNA:TLR9
--
e23
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m23
0
infinite
0
--
LPS:TLR4:MD2:TRAM
--
e24
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m24
0
infinite
0
--
LPS:TLR4:MD2:TRAM:TRIF
--
e25
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m25
0
infinite
0
--
imiquimod
--
e26
cso30:c:SmallMolecule
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m26
0
infinite
0
--
imiquimod:TLR7
--
e27
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m27
0
infinite
0
--
R-848
--
e28
cso30:c:SmallMolecule
cso30:i:CC_Cytosol
--
csml-variable:Double
m28
0
infinite
0
--
R-848:TLR8
--
e29
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m29
0
infinite
0
--
--
e3
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
--
csml-variable:Double
m3
0
infinite
0
--
R-848:TLR7
--
e30
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m30
0
infinite
0
--
LPS:TLR4:MD2:MYD88
--
e31
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m31
0
infinite
0
--
flagellin:TLR5:MYD88
--
e32
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m32
0
infinite
0
--
peptidoglycan:TLR2:MYD88
--
e33
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m33
0
infinite
0
--
ssRNA:TLR7:MYD88
--
e34
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m34
0
infinite
0
--
ssRNA:TLR8:MYD88
--
e35
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m35
0
infinite
0
--
CpG DNA:TLR9:MYD88
--
e36
cso30:c:Complex
cso30:i:CC_EndosomeLumen
--
csml-variable:Double
m36
0
infinite
0
--
IKK-i:TBK1
--
e37
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m37
0
infinite
0
--
IKK-i:TBK1{active}
--
e38
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m38
0
infinite
0
--
IRF-3{p}
--
e39
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m39
10
infinite
0
TRANSPATH | MO000041456 |
--
--
e4
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m4
0
infinite
0
--
enhanceosome complex
--
e41
cso30:c:Complex
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m42
0
infinite
0
--
IFN-beta
--
e42
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m43
0
infinite
0
--
NF-kappaB{active}
--
e43
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m44
10
infinite
0
TRANSPATH | MO000000058 |
--
IFN-alpha
--
e44
cso30:c:Protein
cso30:i:CC_Extracellular
--
csml-variable:Double
m45
0
infinite
0
--
ISGF3
--
e45
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m46
0
infinite
0
--
ISGF3{active}
--
e46
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m47
0
infinite
0
--
IFN-beta
--
e47
cso30:c:Protein
cso30:i:CC_Extracellular
--
csml-variable:Double
m48
0
infinite
0
--
IRF7
--
e48
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
--
csml-variable:Double
m49
0
infinite
0
--
IRF-3{p}:pin1
--
e49
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m63
0
infinite
0
--
TLR4:MD2
--
e5
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m5
0
infinite
0
--
--
e50
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelopeLumen
--
--
--
csml-variable:Double
m50
0
infinite
0
--
--
e51
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearPore
--
--
--
csml-variable:Double
m51
0
infinite
0
--
--
e52
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearInnerMembrane
--
--
--
csml-variable:Double
m52
0
infinite
0
--
--
e53
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearLumen
--
--
--
csml-variable:Double
m53
0
infinite
0
--
--
e54
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearOuterMembrane
--
--
--
csml-variable:Double
m54
0
infinite
0
--
--
e55
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleus
--
--
--
csml-variable:Double
m55
0
infinite
0
--
--
e56
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleoplasm
--
--
--
csml-variable:Double
m56
0
infinite
0
--
--
e57
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearBody
--
--
--
csml-variable:Double
m57
0
infinite
0
--
--
e58
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleolus
--
--
--
csml-variable:Double
m58
0
infinite
0
--
--
e59
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelope
--
--
--
csml-variable:Double
m59
0
infinite
0
--
LPS:TLR4:MD2
--
e6
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m6
0
infinite
0
--
--
e60
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Chromatin
--
--
--
csml-variable:Double
m60
0
infinite
0
--
--
e61
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearChromosome
--
--
--
csml-variable:Double
m61
0
infinite
0
--
--
e62
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearCentromere
--
--
--
csml-variable:Double
m62
0
infinite
0
--
IRF-3{p}{ub}:pin1
--
e63
cso30:c:Complex
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m64
0
infinite
0
--
SARM
--
e64
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m65
0
infinite
0
--
SIKE
--
e65
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m66
0
infinite
0
--
IKK-i:SIKE:TBK1
--
e66
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m67
0
infinite
0
--
JAK
--
e67
cso30:c:Protein
cso30:i:CC_Extracellular
--
csml-variable:Double
m68
0
infinite
0
--
JAK{active}
--
e68
cso30:c:Protein
cso30:i:CC_Extracellular
--
csml-variable:Double
m69
0
infinite
0
--
(stat1{p})2
--
e69
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m70
0
infinite
0
--
--
e7
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell
--
--
--
csml-variable:Double
m7
0
infinite
0
--
(stat1{p})2
--
e70
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m71
0
infinite
0
--
(stat1{p})2:IRF1SBE DNA
--
e71
cso30:c:Complex
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m72
0
infinite
0
--
IRF1SBE
--
e72
cso30:c:Dna
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m73
0
infinite
0
--
IRF7 ISRE:ISGF3{act}
--
e73
cso30:c:Complex
cso30:i:CC_Nucleolus
--
csml-variable:Double
m74
0
infinite
0
--
csml-variable:Double
m75
0
infinite
0
--
IRF1
--
e75
cso30:c:mRNA
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m76
0
infinite
0
--
IFN-alpha1
--
e76
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m77
0
infinite
0
--
IFN-alpha1
--
e77
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m78
0
infinite
0
--
dsRNA:DDX58
--
e78
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m79
0
infinite
0
--
dsRNA:IFIH1
--
e79
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m80
0
infinite
0
--
--
e8
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell_WithoutCellWall_
--
--
--
csml-variable:Double
m8
0
infinite
0
--
dsRNA:DDX58:MAVS
--
e80
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m81
0
infinite
0
--
dsRNA:DDX58:MAVS:IKK
--
e81
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m82
0
infinite
0
--
NF-kappaB
--
e82
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m83
10
infinite
0
TRANSPATH | MO000000058 |
--
IRF
--
e83
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m84
0
infinite
0
--
IRF{active}
--
e84
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m85
0
infinite
0
--
DAI
--
e85
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m86
0
infinite
0
--
DNA:DAI
--
e86
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m87
0
infinite
0
--
HLA-DR
--
e87
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m88
0
infinite
0
--
HLA-DR
--
e88
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m89
0
infinite
0
--
CD54
--
e89
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m90
0
infinite
0
--
--
e9
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytoplasm
--
--
--
csml-variable:Double
m9
0
infinite
0
--
CD54
--
e90
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m91
0
infinite
0
--
CD80
--
e91
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m92
0
infinite
0
--
CD80
--
e92
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m93
0
infinite
0
--
CD86
--
e93
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m94
0
infinite
0
--
CD86
--
e94
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m95
0
infinite
0
--
CXCL9
--
e95
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m96
0
infinite
0
--
CXCL9
--
e96
cso30:c:Protein
cso30:i:CC_Extracellular
--
csml-variable:Double
m97
0
infinite
0
--
CXCL10
--
e97
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m98
0
infinite
0
--
CXCL11
--
e98
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m99
0
infinite
0
--
CXCL10
--
e99
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m100
0
infinite
0
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1
m5*m155666*0.1
nodelay
--
0
PMID: 18054516 TLR4 (together with its soluble coreceptor MD-2) binds Gram (¡Ý) bacteria-derived LPS
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c29 : 1
stoichiometry:c30 : 1
m6*m19005*0.1
nodelay
--
0
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1
stoichiometry:c33 : 1
m24*m18998*0.1
nodelay
--
0
PMID: 18054516, 16410796, 11544529 In the case of TLR4, another adaptor molecule, TRAM, is required to recruit TRIF to TLR4 and, in turn, to induce the pathway leading to the IFN-¦Â expression
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c35 : 1
stoichiometry:c36 : 1
m26*m19940*0.1
nodelay
--
0
PMID: 18054516, 11812998, 12032557, 15661881 In addition to ssRNA, the synthetic imidazoquinoline, imiquimod, a low molecular weight immune response modifier, activates TLR7 in both humans and mice while its derivative resiquimod (R-848) activates TLR7 and TLR8 in humans, but only TLR7 in mice
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c38 : 1
stoichiometry:c39 : 1
m28*m19823*0.1
nodelay
--
0
PMID: 18054516, 11812998, 12032557, 15661881 In addition to ssRNA, the synthetic imidazoquinoline, imiquimod, a low molecular weight immune response modifier, activates TLR7 in both humans and mice while its derivative resiquimod (R-848) activates TLR7 and TLR8 in humans, but only TLR7 in mice
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1
stoichiometry:c42 : 1
m19940*m28*0.1
nodelay
--
0
PMID: 18054516, 11812998, 12032557, 15661881 In addition to ssRNA, the synthetic imidazoquinoline, imiquimod, a low molecular weight immune response modifier, activates TLR7 in both humans and mice while its derivative resiquimod (R-848) activates TLR7 and TLR8 in humans, but only TLR7 in mice
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c44 : 1
stoichiometry:c45 : 1
m6*m1572*0.1
nodelay
--
0
PMID: 18054516, 11544529, 17048703 With the exception of TLR3, which signals solely by TRIF, all TLRs recruit MyD88, which triggers signalling pathways leading to nuclear translocation of NF-¦ÊB
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c47 : 1
stoichiometry:c48 : 1
m18*m1572*0.1
nodelay
--
0
PMID: 18054516, 11544529, 17048703 With the exception of TLR3, which signals solely by TRIF, all TLRs recruit MyD88, which triggers signalling pathways leading to nuclear translocation of NF-¦ÊB
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c50 : 1
stoichiometry:c51 : 1
m11*m1572*0.1
nodelay
--
0
PMID: 18054516, 11544529, 17048703 With the exception of TLR3, which signals solely by TRIF, all TLRs recruit MyD88, which triggers signalling pathways leading to nuclear translocation of NF-¦ÊB
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c53 : 1
stoichiometry:c54 : 1
m19*m1572*0.1
nodelay
--
0
PMID: 18054516, 11544529, 17048703 With the exception of TLR3, which signals solely by TRIF, all TLRs recruit MyD88, which triggers signalling pathways leading to nuclear translocation of NF-¦ÊB
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c56 : 1
stoichiometry:c57 : 1
m21*m1572*0.1
nodelay
--
0
PMID: 18054516, 11544529, 17048703 With the exception of TLR3, which signals solely by TRIF, all TLRs recruit MyD88, which triggers signalling pathways leading to nuclear translocation of NF-¦ÊB
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c6 : 1
stoichiometry:c5 : 1
m3964*m12*0.1
nodelay
--
0
PMID: 18054516 TLR2 recognizes peptidoglycan and lipopeptides
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c59 : 1
stoichiometry:c60 : 1
m23*m1572*0.1
nodelay
--
0
PMID: 18054516, 11544529, 17048703 With the exception of TLR3, which signals solely by TRIF, all TLRs recruit MyD88, which triggers signalling pathways leading to nuclear translocation of NF-¦ÊB
p21
p21
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c63 : 1
stoichiometry:c62 : 1
m37*m19305*0.1
nodelay
--
0
PMID: 18054516, 12702806, 14517278 This pathway mainly mediates the phosphorylation-induced activation of IRF-3 by two IkB kinase-related kinases, inhibitory protein kB kinase (IKK)-var epsilon and TANK binding kinase (TBK)1
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c64 : 1
stoichiometry:c66 : 1
stoichiometry:c65 : 1
m37*m25*0.1
nodelay
--
0
PMID: 18054516, 12702806, 14517278 This pathway mainly mediates the phosphorylation-induced activation of IRF-3 by two IkB kinase-related kinases, inhibitory protein kB kinase (IKK)-var epsilon and TANK binding kinase (TBK)1
p23
p23
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c69 : 1
stoichiometry:c68 : 1
m977*m38*0.1
nodelay
--
0
PMID: 18054516, 12702806, 14517278 This pathway mainly mediates the phosphorylation-induced activation of IRF-3 by two IkB kinase-related kinases, inhibitory protein kB kinase (IKK)-var epsilon and TANK binding kinase (TBK)1
p24
p24
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1
stoichiometry:c72 : 1
stoichiometry:c118 : 1
stoichiometry:c71 : 1
m980*m38*0.1
nodelay
--
0
PMID: 18054516, 16214811, 12821121 Recent reports have also shown that IRF-7 can be directly activated by TLR4 and TLR3 in IRF-3-deficient DC indicating that IRF-7 may potentiate the IRF-3-dependent induction of IFN-¦Â PMID: 18054516, 9786932, 9877175 Similar to IRF-3, IRF-7 undergoes serine phosphorylation by IKK-var epsilon and TBK1 followed by nuclear translocation PMID: 18054516, 16964262 Carty et al. recently demonstrated that a TIR adaptor SARM inhibits TRIF-induced IRF-7 activation in TLR3 or TLR4-stimulated cells
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c74 : 1
m19324*0.1
nodelay
--
0
PMID: 18054516, 9786932, 9877175 Similar to IRF-3, IRF-7 undergoes serine phosphorylation by IKK-var epsilon and TBK1 followed by nuclear translocation
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c75 : 1
stoichiometry:c76 : 1
m19325*0.1
nodelay
--
0
PMID: 18054516, 9786932, 9877175 Similar to IRF-3, IRF-7 undergoes serine phosphorylation by IKK-var epsilon and TBK1 followed by nuclear translocation
p27
p27
cso30:i:ME_Binding
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c78 : 1
stoichiometry:c79 : 1
stoichiometry:c80 : 1
stoichiometry:c81 : 1
m39*m40*m41*m31298*0.1
nodelay
--
0
PMID: 18054516, 3329166, 16932750, 16979567 These events result in the assembly of the enhanceosome, a multiprotein complex consisting of ATF2/c-Jun, IRF-3/IRF-7, and NF-¦ÊB, all of which are required for the transcription of the IFN-¦Â gene
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c83 : 1
m42*0.1
nodelay
--
0
PMID: 18054516, 3329166, 16932750, 16979567 These events result in the assembly of the enhanceosome, a multiprotein complex consisting of ATF2/c-Jun, IRF-3/IRF-7, and NF-¦ÊB, all of which are required for the transcription of the IFN-¦Â gene PMID: 18054516, 12077266, 14991609 In particular, the stimulation of TLR3 and TLR4 is associated mainly with the release of IFN-¦Â and a poor production of IFN-¦Á1 from human myeloid DC PMID: 18054516, 12077266, 14991609, 16846591 In myeloid DC the activation of IRF-3 following TLR3 or TLR4 triggering is responsible for the selective expression of IFN-¦Â and IFN-¦Á1 which contain in their promoter specific sequences recognizing this transcription factor
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c86 : 1
stoichiometry:c85 : 1
m44*m31*0.1
nodelay
--
0
PMID: 18054516, 11544529, 17048703 With the exception of TLR3, which signals solely by TRIF, all TLRs recruit MyD88, which triggers signalling pathways leading to nuclear translocation of NF-¦ÊB
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1
m13*m3964*0.1
nodelay
--
0
PMID: 18054516 TLR2 recognizes peptidoglycan and lipopeptides
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c89 : 1
stoichiometry:c88 : 1
m44*m34*0.1
nodelay
--
0
PMID: 18054516, 11544529, 17048703 With the exception of TLR3, which signals solely by TRIF, all TLRs recruit MyD88, which triggers signalling pathways leading to nuclear translocation of NF-¦ÊB
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c90 : 1
stoichiometry:c92 : 1
stoichiometry:c91 : 1
m44*m35*0.1
nodelay
--
0
PMID: 18054516, 11544529, 17048703 With the exception of TLR3, which signals solely by TRIF, all TLRs recruit MyD88, which triggers signalling pathways leading to nuclear translocation of NF-¦ÊB
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c95 : 1
stoichiometry:c94 : 1
m44*m36*0.1
nodelay
--
0
PMID: 18054516, 11544529, 17048703 With the exception of TLR3, which signals solely by TRIF, all TLRs recruit MyD88, which triggers signalling pathways leading to nuclear translocation of NF-¦ÊB
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c96 : 1
stoichiometry:c98 : 1
stoichiometry:c97 : 1
m44*m32*0.1
nodelay
--
0
PMID: 18054516, 11544529, 17048703 With the exception of TLR3, which signals solely by TRIF, all TLRs recruit MyD88, which triggers signalling pathways leading to nuclear translocation of NF-¦ÊB
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c101 : 1
stoichiometry:c100 : 1
m44*m33*0.1
nodelay
--
0
PMID: 18054516, 11544529, 17048703 With the exception of TLR3, which signals solely by TRIF, all TLRs recruit MyD88, which triggers signalling pathways leading to nuclear translocation of NF-¦ÊB
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c107 : 1
stoichiometry:c102 : 1
stoichiometry:c103 : 1
m48*m46*0.1
nodelay
--
0
PMID: 18054516, 9822609 While IRF-3 is constitutively expressed, IRF-7 expression is induced by IFN-¦Á/¦Â through the activation of IFN-stimulated gene factor (ISGF)-3
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c104 : 1
stoichiometry:c105 : 1
m45*m46*0.1
nodelay
--
0
PMID: 18054516, 9822609 While IRF-3 is constitutively expressed, IRF-7 expression is induced by IFN-¦Á/¦Â through the activation of IFN-stimulated gene factor (ISGF)-3
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c108 : 1
stoichiometry:c146 : 1
m72*0.1
nodelay
--
0
PMID: 18054516 Among these, IRF-1 and IRF-7 are transcriptionally regulated by SBE and ISRE sites present within their respective promoters.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c110 : 1
stoichiometry:c111 : 1
stoichiometry:c112 : 1
m39*m2065*0.1
nodelay
--
0
PMID: 18054516, 16699525 The peptidyl prolyl isomerase Pin1 interacts with IRF-3 in the nucleus and facilitates the conjugation of polyubiquitin and the proteasome-dependent degradation of IRF-3, thereby blocking the IFN-¦Â production downstream of TLR3, TLR4 and RIG-I pathways
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c113 : 1
stoichiometry:c114 : 1
m63*0.1
nodelay
--
0
PMID: 18054516, 16699525 The peptidyl prolyl isomerase Pin1 interacts with IRF-3 in the nucleus and facilitates the conjugation of polyubiquitin and the proteasome-dependent degradation of IRF-3, thereby blocking the IFN-¦Â production downstream of TLR3, TLR4 and RIG-I pathways
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c12 : 1
stoichiometry:c11 : 1
m3966*m6485*0.1
nodelay
--
0
PMID: 18054516 TLR5 recognizes flagellin
p40
p40
cso30:i:ME_ProteasomeDegradation
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c115 : 1
stoichiometry:c116 : 1
stoichiometry:c117 : 1
m64*0.1
nodelay
--
0
PMID: 18054516, 16699525 The peptidyl prolyl isomerase Pin1 interacts with IRF-3 in the nucleus and facilitates the conjugation of polyubiquitin and the proteasome-dependent degradation of IRF-3, thereby blocking the IFN-¦Â production downstream of TLR3, TLR4 and RIG-I pathways
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c119 : 1
stoichiometry:c120 : 1
stoichiometry:c121 : 1
m37*m66*0.1
nodelay
--
0
PMID: 18054516 Suppressor IKKvar epsilon (SIKE) is a suppressor that interacts with both TBK1 and IKKvar epsilon and sequester them in inactive complex.
p42
p42
cso30:i:ME_Dissociation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c122 : 1
stoichiometry:c125 : 1
stoichiometry:c123 : 1
stoichiometry:c124 : 1
m67*m19314*0.1
nodelay
--
0
PMID: 18054516 Upon viral infection or TLR3 triggering, SIKE dissociates from TBK1 and IKKvar epsilon allowing type I IFN gene expression.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c126 : 1
stoichiometry:c130 : 1
stoichiometry:c131 : 1
m45*m68*0.1
nodelay
--
0
PMID: 18054516, 10817963 Once secreted from infected cells, IFNs induce in an autocrine and paracrine fashion the activation of Janus kinases (JAKs) and STAT transcription factors, leading to expression of IFN-stimulated genes (ISGs)
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c127 : 1
stoichiometry:c128 : 1
stoichiometry:c129 : 1
m48*m68*0.1
nodelay
--
0
PMID: 18054516, 10817963 Once secreted from infected cells, IFNs induce in an autocrine and paracrine fashion the activation of Janus kinases (JAKs) and STAT transcription factors, leading to expression of IFN-stimulated genes (ISGs)
p45
p45
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c132 : 1
stoichiometry:c134 : 1
stoichiometry:c133 : 1
m1357*m69*0.1
nodelay
--
0
PMID: 18054516, 10817963 Once secreted from infected cells, IFNs induce in an autocrine and paracrine fashion the activation of Janus kinases (JAKs) and STAT transcription factors, leading to expression of IFN-stimulated genes (ISGs) PMID: 18054516 Upon phosphorylation and translocation into the nucleus, STAT bind as STAT-1 homodimer (GAF, IFN-¦Ã activated factor) to STAT binding element (SBE) or as heterotrimeric ISGF-3 complex (consisting of IRF-9, STAT-1 and STAT-2) to the IFN-stimulated response element (ISRE) in the promoter of target genes.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c135 : 1
stoichiometry:c136 : 1
m4238*0.1
nodelay
--
0
PMID: 18054516 Upon phosphorylation and translocation into the nucleus, STAT bind as STAT-1 homodimer (GAF, IFN-¦Ã activated factor) to STAT binding element (SBE) or as heterotrimeric ISGF-3 complex (consisting of IRF-9, STAT-1 and STAT-2) to the IFN-stimulated response element (ISRE) in the promoter of target genes.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c137 : 1
stoichiometry:c138 : 1
m70*0.1
nodelay
--
0
PMID: 18054516 Upon phosphorylation and translocation into the nucleus, STAT bind as STAT-1 homodimer (GAF, IFN-¦Ã activated factor) to STAT binding element (SBE) or as heterotrimeric ISGF-3 complex (consisting of IRF-9, STAT-1 and STAT-2) to the IFN-stimulated response element (ISRE) in the promoter of target genes.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c139 : 1
stoichiometry:c141 : 1
stoichiometry:c140 : 1
m71*m73*0.1
nodelay
--
0
PMID: 18054516 Upon phosphorylation and translocation into the nucleus, STAT bind as STAT-1 homodimer (GAF, IFN-¦Ã activated factor) to STAT binding element (SBE) or as heterotrimeric ISGF-3 complex (consisting of IRF-9, STAT-1 and STAT-2) to the IFN-stimulated response element (ISRE) in the promoter of target genes.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c142 : 1
stoichiometry:c144 : 1
stoichiometry:c143 : 1
m47*m75*0.1
nodelay
--
0
PMID: 18054516 Upon phosphorylation and translocation into the nucleus, STAT bind as STAT-1 homodimer (GAF, IFN-¦Ã activated factor) to STAT binding element (SBE) or as heterotrimeric ISGF-3 complex (consisting of IRF-9, STAT-1 and STAT-2) to the IFN-stimulated response element (ISRE) in the promoter of target genes.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c15 : 1
stoichiometry:c14 : 1
m19940*m20*0.1
nodelay
--
0
PMID: 18054516, 14976261, 14976262 TLR7 and TLR8 recognize single-strand (ss)RNA and are also activated by infections with ssRNA viruses, including influenza virus and vesicular stomatitis virus
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c109 : 1
stoichiometry:c145 : 1
m74*0.1
nodelay
--
0
PMID: 18054516, 9822609 While IRF-3 is constitutively expressed, IRF-7 expression is induced by IFN-¦Á/¦Â through the activation of IFN-stimulated gene factor (ISGF)-3 PMID: 18054516 Among these, IRF-1 and IRF-7 are transcriptionally regulated by SBE and ISRE sites present within their respective promoters
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c147 : 1
stoichiometry:c148 : 1
m43*0.1
nodelay
--
0
PMID: 18054516, 12077266, 14991609 In particular, the stimulation of TLR3 and TLR4 is associated mainly with the release of IFN-¦Â and a poor production of IFN-¦Á1 from human myeloid DC PMID: 18054516, 12077266, 14991609, 16846591 In myeloid DC the activation of IRF-3 following TLR3 or TLR4 triggering is responsible for the selective expression of IFN-¦Â and IFN-¦Á1 which contain in their promoter specific sequences recognizing this transcription factor
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c150 : 1
stoichiometry:c149 : 1
m39*0.1
nodelay
--
0
PMID: 18054516, 12077266, 14991609 In particular, the stimulation of TLR3 and TLR4 is associated mainly with the release of IFN-¦Â and a poor production of IFN-¦Á1 from human myeloid DC PMID: 18054516, 12077266, 14991609, 16846591 In myeloid DC the activation of IRF-3 following TLR3 or TLR4 triggering is responsible for the selective expression of IFN-¦Â and IFN-¦Á1 which contain in their promoter specific sequences recognizing this transcription factor
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c151 : 1
stoichiometry:c152 : 1
m77*0.1
nodelay
--
0
PMID: 18054516, 12077266, 14991609 In particular, the stimulation of TLR3 and TLR4 is associated mainly with the release of IFN-¦Â and a poor production of IFN-¦Á1 from human myeloid DC PMID: 18054516, 12077266, 14991609, 16846591 In myeloid DC the activation of IRF-3 following TLR3 or TLR4 triggering is responsible for the selective expression of IFN-¦Â and IFN-¦Á1 which contain in their promoter specific sequences recognizing this transcription factor
p54
p54
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c153 : 1
stoichiometry:c154 : 1
stoichiometry:c155 : 1
m119368*m41844*0.1
nodelay
--
0
PMID: 18054516 During a viral infection, RIG-1 and MDA5 are activated upon detection of dsRNA by the RNA helicase domain, and trigger the activation of NF-¦ÊB and IRF3/7, which cooperate in the induction of type I IFNs
p55
p55
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c156 : 1
stoichiometry:c157 : 1
stoichiometry:c158 : 1
m119368*m76904*0.1
nodelay
--
0
PMID: 18054516 During a viral infection, RIG-1 and MDA5 are activated upon detection of dsRNA by the RNA helicase domain, and trigger the activation of NF-¦ÊB and IRF3/7, which cooperate in the induction of type I IFNs
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c159 : 1
stoichiometry:c161 : 1
stoichiometry:c160 : 1
m79*m68199*0.1
nodelay
--
0
PMID: 18054516, 16177806, 16125763, 16127453, 16039576 It has been proposed that once activated by dsRNA, RIG-I interacts with IPS-1 via their respective CARD domains, resulting in the recruitment of appropriate signalling intermediates, such as IKKs for NF-¦ÊB and IRF activation
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c162 : 1
stoichiometry:c163 : 1
stoichiometry:c164 : 1
m81*m207*0.1
nodelay
--
0
PMID: 18054516, 16177806, 16125763, 16127453, 16039576 It has been proposed that once activated by dsRNA, RIG-I interacts with IPS-1 via their respective CARD domains, resulting in the recruitment of appropriate signalling intermediates, such as IKKs for NF-¦ÊB and IRF activation
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c165 : 1
stoichiometry:c167 : 1
stoichiometry:c166 : 1
m83*m82*0.1
nodelay
--
0
PMID: 18054516, 16177806, 16125763, 16127453, 16039576 It has been proposed that once activated by dsRNA, RIG-I interacts with IPS-1 via their respective CARD domains, resulting in the recruitment of appropriate signalling intermediates, such as IKKs for NF-¦ÊB and IRF activation
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c168 : 1
stoichiometry:c170 : 1
stoichiometry:c169 : 1
m84*m82*0.1
nodelay
--
0
PMID: 18054516, 16177806, 16125763, 16127453, 16039576 It has been proposed that once activated by dsRNA, RIG-I interacts with IPS-1 via their respective CARD domains, resulting in the recruitment of appropriate signalling intermediates, such as IKKs for NF-¦ÊB and IRF activation
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1
m19823*m20*0.1
nodelay
--
0
PMID: 18054516, 14976261, 14976262 TLR7 and TLR8 recognize single-strand (ss)RNA and are also activated by infections with ssRNA viruses, including influenza virus and vesicular stomatitis virus
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c171 : 1
stoichiometry:c172 : 1
stoichiometry:c173 : 1
m22*m86*0.1
nodelay
--
0
PMID: 18054516, 17618271 The very recent identification of DNA-dependent activator of IRF (DAI) as a cytosolic DNA sensor able to induce type I IFN expression following the recognition of different sources of microbial DNA, provides an explanation of how different pathogens may induce type I IFN genes through a unique pathway
PMID: 18054516, 15101709, 16769767, 12513906 type I IFNs promote the differentiation of human blood monocytes into DC and contribute to their maturation
PMID: 18054516, 15101709, 16769767, 12513906 type I IFNs promote the differentiation of human blood monocytes into DC and contribute to their maturation
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c179 : 1
stoichiometry:c178 : 1
m45*0.1
nodelay
--
0
PMID: 18054516, 15101709, 16769767, 12513906 In particular, it was reported that blood monocytes maintained in culture for 3 days with IFN-¦Á express high levels of HLA-DR, of costimulatory molecules CD80, CD86 and of adhesion molecule CD54
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c177 : 1
stoichiometry:c180 : 1
stoichiometry:c176 : 1
m88*m45*0.1
nodelay
--
0
PMID: 18054516, 15101709, 16769767, 12513906 In particular, it was reported that blood monocytes maintained in culture for 3 days with IFN-¦Á express high levels of HLA-DR, of costimulatory molecules CD80, CD86 and of adhesion molecule CD54
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c184 : 1
stoichiometry:c183 : 1
m45*0.1
nodelay
--
0
PMID: 18054516, 15101709, 16769767, 12513906 In particular, it was reported that blood monocytes maintained in culture for 3 days with IFN-¦Á express high levels of HLA-DR, of costimulatory molecules CD80, CD86 and of adhesion molecule CD54
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c182 : 1
stoichiometry:c185 : 1
stoichiometry:c181 : 1
m90*m45*0.1
nodelay
--
0
PMID: 18054516, 15101709, 16769767, 12513906 In particular, it was reported that blood monocytes maintained in culture for 3 days with IFN-¦Á express high levels of HLA-DR, of costimulatory molecules CD80, CD86 and of adhesion molecule CD54
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c187 : 1
stoichiometry:c186 : 1
m45*0.1
nodelay
--
0
PMID: 18054516, 15101709, 16769767, 12513906 In particular, it was reported that blood monocytes maintained in culture for 3 days with IFN-¦Á express high levels of HLA-DR, of costimulatory molecules CD80, CD86 and of adhesion molecule CD54
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c189 : 1
stoichiometry:c190 : 1
stoichiometry:c188 : 1
m92*m45*0.1
nodelay
--
0
PMID: 18054516, 15101709, 16769767, 12513906 In particular, it was reported that blood monocytes maintained in culture for 3 days with IFN-¦Á express high levels of HLA-DR, of costimulatory molecules CD80, CD86 and of adhesion molecule CD54
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c191 : 1
stoichiometry:c193 : 1
stoichiometry:c192 : 1
m94*m45*0.1
nodelay
--
0
PMID: 18054516, 15101709, 16769767, 12513906 In particular, it was reported that blood monocytes maintained in culture for 3 days with IFN-¦Á express high levels of HLA-DR, of costimulatory molecules CD80, CD86 and of adhesion molecule CD54
p7
p7
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1
m119368*m3965*0.1
nodelay
--
0
PMID: 18054516 TLR3 is triggered by double-strand (ds)RNA.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c195 : 1
stoichiometry:c194 : 1
m45*0.1
nodelay
--
0
PMID: 18054516, 15101709, 16769767, 12513906 In particular, it was reported that blood monocytes maintained in culture for 3 days with IFN-¦Á express high levels of HLA-DR, of costimulatory molecules CD80, CD86 and of adhesion molecule CD54
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c196 : 1
stoichiometry:c197 : 1
m45*0.1
nodelay
--
0
PMID: 18054516 In particular, the expression of CXCR3 binding chemokines, CXCL9, CXCL10 and CXCL11, is dependent on type I IFNs.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c198 : 1
stoichiometry:c199 : 1
m48*0.1
nodelay
--
0
PMID: 18054516 In particular, the expression of CXCR3 binding chemokines, CXCL9, CXCL10 and CXCL11, is dependent on type I IFNs.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c202 : 1
stoichiometry:c204 : 1
stoichiometry:c200 : 1
m96*m45*0.1
nodelay
--
0
PMID: 18054516 In particular, the expression of CXCR3 binding chemokines, CXCL9, CXCL10 and CXCL11, is dependent on type I IFNs.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c203 : 1
stoichiometry:c205 : 1
stoichiometry:c201 : 1
m96*m48*0.1
nodelay
--
0
PMID: 18054516 In particular, the expression of CXCR3 binding chemokines, CXCL9, CXCL10 and CXCL11, is dependent on type I IFNs.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c218 : 1
stoichiometry:c206 : 1
m45*0.1
nodelay
--
0
PMID: 18054516 In particular, the expression of CXCR3 binding chemokines, CXCL9, CXCL10 and CXCL11, is dependent on type I IFNs.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c222 : 1
stoichiometry:c207 : 1
m48*0.1
nodelay
--
0
PMID: 18054516 In particular, the expression of CXCR3 binding chemokines, CXCL9, CXCL10 and CXCL11, is dependent on type I IFNs.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c210 : 1
stoichiometry:c220 : 1
stoichiometry:c208 : 1
m99*m45*0.1
nodelay
--
0
PMID: 18054516 In particular, the expression of CXCR3 binding chemokines, CXCL9, CXCL10 and CXCL11, is dependent on type I IFNs.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c211 : 1
stoichiometry:c224 : 1
stoichiometry:c209 : 1
m99*m48*0.1
nodelay
--
0
PMID: 18054516 In particular, the expression of CXCR3 binding chemokines, CXCL9, CXCL10 and CXCL11, is dependent on type I IFNs.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c214 : 1
stoichiometry:c221 : 1
stoichiometry:c212 : 1
m98*m45*0.1
nodelay
--
0
PMID: 18054516 In particular, the expression of CXCR3 binding chemokines, CXCL9, CXCL10 and CXCL11, is dependent on type I IFNs.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1
m19828*m22*0.1
nodelay
--
0
PMID: 18054516 TLR9 is known to bind unmethylated bacterial and viral dsDNA
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c215 : 1
stoichiometry:c225 : 1
stoichiometry:c213 : 1
m98*m48*0.1
nodelay
--
0
PMID: 18054516 In particular, the expression of CXCR3 binding chemokines, CXCL9, CXCL10 and CXCL11, is dependent on type I IFNs.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c219 : 1
stoichiometry:c216 : 1
m45*0.1
nodelay
--
0
PMID: 18054516 In particular, the expression of CXCR3 binding chemokines, CXCL9, CXCL10 and CXCL11, is dependent on type I IFNs.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c223 : 1
stoichiometry:c217 : 1
m48*0.1
nodelay
--
0
PMID: 18054516 In particular, the expression of CXCR3 binding chemokines, CXCL9, CXCL10 and CXCL11, is dependent on type I IFNs.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c230 : 1
stoichiometry:c231 : 1
stoichiometry:c226 : 1
m104*0.1
nodelay
--
0
PMID: 18054516, 10604988 On the other hand, CD40-dependent IL-12 production from monocyte-derived DC was shown to be impaired by IFN-¦Â
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c227 : 1
stoichiometry:c229 : 1
stoichiometry:c232 : 1
stoichiometry:c228 : 1
m102*m104*0.1
nodelay
--
0
PMID: 18054516, 10604988 On the other hand, CD40-dependent IL-12 production from monocyte-derived DC was shown to be impaired by IFN-¦Â
p85
p85
cso30:i:ME_Translation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c236 : 1
stoichiometry:c238 : 1
stoichiometry:c234 : 1
m105*m19314*0.1
nodelay
--
0
PMID: 18054516, 16624932 Among the STAT transcription factors involved in type I IFN signalling, STAT-1 and -2 contents are increased in DC stimulated with LPS or poly I:C
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c235 : 1
stoichiometry:c237 : 1
stoichiometry:c233 : 1
m105*m6*0.1
nodelay
--
0
PMID: 18054516, 16624932 Among the STAT transcription factors involved in type I IFN signalling, STAT-1 and -2 contents are increased in DC stimulated with LPS or poly I:C
p87
p87
cso30:i:ME_Translation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c240 : 1
stoichiometry:c244 : 1
stoichiometry:c241 : 1
m94507*m19314*0.1
nodelay
--
0
PMID: 18054516, 16624932 Among the STAT transcription factors involved in type I IFN signalling, STAT-1 and -2 contents are increased in DC stimulated with LPS or poly I:C
p88
p88
cso30:i:ME_Translation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c239 : 1
stoichiometry:c243 : 1
stoichiometry:c242 : 1
m94507*m6*0.1
nodelay
--
0
PMID: 18054516, 16624932 Among the STAT transcription factors involved in type I IFN signalling, STAT-1 and -2 contents are increased in DC stimulated with LPS or poly I:C
p89
p89
cso30:i:ME_GeneExpression
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c245 : 1
stoichiometry:c246 : 1
m41*0.1
nodelay
--
0
PMID: 18054516 Thus, under inflammatory conditions, NF-¦ÊB is activated and, in turn, induces STAT-4 whose activation by type I IFNs may regulate the transcription of specific target genes in mature DC.
p9
p9
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1
m19314*m18998*0.1
nodelay
--
0
PMID: 18054516, 11544529, 16410796 With the exception of TLR3, which signals solely by TRIF, all TLRs recruit MyD88, which triggers signalling pathways leading to nuclear translocation of NF-¦ÊB
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c247 : 1
stoichiometry:c248 : 1
m94523*0.1
nodelay
--
0
PMID: 18054516 Thus, under inflammatory conditions, NF-¦ÊB is activated and, in turn, induces STAT-4 whose activation by type I IFNs may regulate the transcription of specific target genes in mature DC.
p91
p91
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c249 : 1
stoichiometry:c251 : 1
stoichiometry:c250 : 1
m2053*m45*0.1
nodelay
--
0
PMID: 18054516 Thus, under inflammatory conditions, NF-¦ÊB is activated and, in turn, induces STAT-4 whose activation by type I IFNs may regulate the transcription of specific target genes in mature DC.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c252 : 1
stoichiometry:c253 : 1
m106*0.1
nodelay
--
0
PMID: 18054516 Thus, under inflammatory conditions, NF-¦ÊB is activated and, in turn, induces STAT-4 whose activation by type I IFNs may regulate the transcription of specific target genes in mature DC.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c254 : 1
stoichiometry:c256 : 1
stoichiometry:c255 : 1
m83*m11*0.1
nodelay
--
0
PMID: 18054516 STAT-4 expression can be induced in human primary DC by multiple stimuli activating NF-¦ÊB transcription factors, such as the ligands for TLR4, TLR2 and TLR3, various pathogens, CD40L and the pro-inflammatory cytokines TNF-¦Á and IL-1¦Â. PMID: 18054516 Thus, under inflammatory conditions, NF-¦ÊB is activated and, in turn, induces STAT-4 whose activation by type I IFNs may regulate the transcription of specific target genes in mature DC.
p94
p94
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c257 : 1
stoichiometry:c259 : 1
stoichiometry:c258 : 1
m83*m19314*0.1
nodelay
--
0
PMID: 18054516 STAT-4 expression can be induced in human primary DC by multiple stimuli activating NF-¦ÊB transcription factors, such as the ligands for TLR4, TLR2 and TLR3, various pathogens, CD40L and the pro-inflammatory cytokines TNF-¦Á and IL-1¦Â. PMID: 18054516 Thus, under inflammatory conditions, NF-¦ÊB is activated and, in turn, induces STAT-4 whose activation by type I IFNs may regulate the transcription of specific target genes in mature DC.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c260 : 1
stoichiometry:c262 : 1
stoichiometry:c261 : 1
m83*m6*0.1
nodelay
--
0
PMID: 18054516 STAT-4 expression can be induced in human primary DC by multiple stimuli activating NF-¦ÊB transcription factors, such as the ligands for TLR4, TLR2 and TLR3, various pathogens, CD40L and the pro-inflammatory cytokines TNF-¦Á and IL-1¦Â. PMID: 18054516 Thus, under inflammatory conditions, NF-¦ÊB is activated and, in turn, induces STAT-4 whose activation by type I IFNs may regulate the transcription of specific target genes in mature DC.
p96
p96
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c263 : 1
stoichiometry:c265 : 1
stoichiometry:c264 : 1
m83*m230*0.1
nodelay
--
0
PMID: 18054516 STAT-4 expression can be induced in human primary DC by multiple stimuli activating NF-¦ÊB transcription factors, such as the ligands for TLR4, TLR2 and TLR3, various pathogens, CD40L and the pro-inflammatory cytokines TNF-¦Á and IL-1¦Â. PMID: 18054516 Thus, under inflammatory conditions, NF-¦ÊB is activated and, in turn, induces STAT-4 whose activation by type I IFNs may regulate the transcription of specific target genes in mature DC.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c266 : 1
stoichiometry:c268 : 1
stoichiometry:c267 : 1
m83*m108*0.1
nodelay
--
0
PMID: 18054516 STAT-4 expression can be induced in human primary DC by multiple stimuli activating NF-¦ÊB transcription factors, such as the ligands for TLR4, TLR2 and TLR3, various pathogens, CD40L and the pro-inflammatory cytokines TNF-¦Á and IL-1¦Â. PMID: 18054516 Thus, under inflammatory conditions, NF-¦ÊB is activated and, in turn, induces STAT-4 whose activation by type I IFNs may regulate the transcription of specific target genes in mature DC.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c269 : 1
stoichiometry:c271 : 1
stoichiometry:c270 : 1
m83*m109*0.1
nodelay
--
0
PMID: 18054516 STAT-4 expression can be induced in human primary DC by multiple stimuli activating NF-¦ÊB transcription factors, such as the ligands for TLR4, TLR2 and TLR3, various pathogens, CD40L and the pro-inflammatory cytokines TNF-¦Á and IL-1¦Â. PMID: 18054516 Thus, under inflammatory conditions, NF-¦ÊB is activated and, in turn, induces STAT-4 whose activation by type I IFNs may regulate the transcription of specific target genes in mature DC.
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
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0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
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0
1,
--
cso30:c:OutputProcess
threshold
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0
1,
--
cso30:c:InputAssociation
threshold
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0
1,
--
cso30:c:InputAssociation
threshold
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0
1,
--
cso30:c:InputAssociation
threshold
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0
1,
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cso30:c:InputAssociation
threshold
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0
1,
--
cso30:c:InputProcess
threshold
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0
1,
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cso30:c:InputProcess
threshold
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0
1,
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cso30:c:OutputProcess
threshold
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0
1,
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cso30:c:InputAssociation
threshold
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0
1,
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cso30:c:InputAssociation
threshold
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0
1,
--
cso30:c:InputProcess
threshold
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0
1,
--
cso30:c:InputAssociation
threshold
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1,
--
cso30:c:InputProcess
threshold
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0
1,
--
cso30:c:InputAssociation
threshold
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0
1,
--
cso30:c:InputAssociation
threshold
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0
1,
--
cso30:c:InputAssociation
threshold
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0
1,
--
cso30:c:OutputProcess
threshold
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--
cso30:c:InputAssociation
threshold
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1,
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cso30:c:OutputProcess
threshold
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0
1,
--
cso30:c:OutputProcess
threshold
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1,
--
cso30:c:InputAssociation
threshold
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1,
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cso30:c:OutputProcess
threshold
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--
cso30:c:OutputProcess
threshold
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cso30:c:InputProcess
threshold
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cso30:c:InputProcess
threshold
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--
cso30:c:InputProcess
threshold
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cso30:c:InputProcess
threshold
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cso30:c:OutputProcess
threshold
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cso30:c:InputProcess
threshold
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1,
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cso30:c:InputProcess
threshold
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cso30:c:OutputProcess
threshold
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cso30:c:InputProcess
threshold
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cso30:c:InputProcess
threshold
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cso30:c:OutputProcess
threshold
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cso30:c:InputProcess
threshold
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cso30:c:OutputProcess
threshold
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--
cso30:c:InputProcess
threshold
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cso30:c:OutputProcess
threshold
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cso30:c:InputProcess
threshold
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--
cso30:c:OutputProcess
threshold
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--
cso30:c:InputProcess
threshold
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0
1,
--
cso30:c:OutputProcess
threshold
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0
1,
--
cso30:c:InputProcess
threshold
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0
1,
--
cso30:c:InputProcess
threshold
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0
1,
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cso30:c:InputAssociation
threshold
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0
1,
--
cso30:c:OutputProcess
threshold
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0
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cso30:c:InputAssociation
threshold
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cso30:c:InputAssociation
threshold
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cso30:c:InputAssociation
threshold
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0
1,
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cso30:c:InputProcess
threshold
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1,
--
cso30:c:OutputProcess
threshold
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1,
--
cso30:c:InputProcess
threshold
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1,
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cso30:c:OutputProcess
threshold
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1,
--
cso30:c:InputProcess
threshold
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1,
--
cso30:c:InputProcess
threshold
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0
1,
--
cso30:c:InputProcess
threshold
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0
1,
--
cso30:c:InputProcess
threshold
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0
1,
--
cso30:c:InputAssociation
threshold
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0
1,
--
cso30:c:InputAssociation
threshold
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0
1,
--
cso30:c:InputProcess
threshold
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0
1,
--
cso30:c:InputAssociation
threshold
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0
1,
--
cso30:c:OutputProcess
threshold
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0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--