majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:18031251.csml convertedTime:2009.07.01.11:10

Entity

G000317:IL8 G010389:IL-1beta G010430:VCAM-1 MO000000308:VCAM-1 MO000016597:IL-1beta MO000016882:LPS MO000017264:IL-8 MO000017793:Lp MO000022185:flagellin e1: e10: e11:Surfactant protein e12:LPS: Surfactant protein e13:Neutrophil protease e2: e3: e4: e5:Tissue factor e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:Tissue factor e60: e61: e62: e7: e8: e9:

Process

p1 p2 p3 p4 p5 p6 p7 p8
461.0, 1006.0
43.5, 43.5

IL8

--

G000317

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p1 p2 p3 p8

true true true true

csml-variable:Double

m87556

10

false

infinite

0

unit false false false
Affymetrix1369_s_at
EnsemblENSG00000169429
HGNCIL8
OMIM146930
ProteomeHumanPSD/IL8
RefSeqNM_000584
TRANSFACG000317
UnigeneHs.551925

--

Go back
426.0, 915.0
34.0, 34.0

IL-1beta

--

G010389

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p4

true true true true

csml-variable:Double

m93364

10

false

infinite

0

unit false false false
TRANSFACG010389

--

Go back
506.0, 786.0
36.0, 36.0

VCAM-1

--

G010430

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m93402

10

false

infinite

0

unit false false false
TRANSFACG010430

--

Go back
355.0, 724.0
32.0, 32.0

VCAM-1

--

MO000000308

cso30:c:Protein

cso30:i:CC_CellComponent

--

p5

--

true true true true

csml-variable:Double

m243

10

false

infinite

0

unit false false false
InterProIPR003987
TRANSPATHMO000000308

--

Go back
272.0, 889.0
38.0, 38.0

IL-1beta

--

MO000016597

cso30:c:Protein

cso30:i:CC_CellComponent

--

p4

--

true true true true

csml-variable:Double

m1591

10

false

infinite

0

unit false false false
TRANSPATHMO000016597

--

Go back
110.0, 888.0
39.0, 39.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p4 p6 p5 p7

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
265.0, 1037.0
29.0, 29.0

IL-8

--

MO000017264

cso30:c:Protein

cso30:i:CC_CellComponent

--

p1 p2 p3 p8

--

true true true true

csml-variable:Double

m2120

10

false

infinite

0

unit false false false
InterProIPR002473
TRANSPATHMO000017264

--

Go back
110.0, 997.0
41.0, 41.0

Lp

--

MO000017793

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m2549

10

false

infinite

0

unit false false false
TRANSPATHMO000017793

--

Go back
112.0, 1063.0
41.0, 41.0

flagellin

--

MO000022185

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m6485

10

false

infinite

0

unit false false false
TRANSPATHMO000022185

--

Go back
188.52277248073258, 46.011693197018275
813.4866586957203, 1201.2739088803078

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
196.36065979605104, 64.3726086510174
788.5176834328865, 1128.089941752253

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
109.5, 770.125
37.0, 27.749999999999996

Surfactant protein

--

e11

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p7

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
41.625, 821.5
36.75, 45.0

LPS: Surfactant protein

--

e12

cso30:c:Complex

cso30:i:CC_Extracellular

--

p7

--

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
272.125, 1108.5
23.520577581002208, 38.14147715838196

Neutrophil protease

--

e13

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p8

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
188.52277248073258, 46.011693197018275
813.4866586957203, 1201.2739088803078

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
204.792505654647, 62.55816577112725
780.9471923478917, 1168.1809637320905

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
234.89151202638874, 91.5144927758177
720.7491796044084, 1110.2683097227086

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
287.52757093982694, 844.125
37.97242906017308, 23.416331253773393

Tissue factor

--

e5

cso30:c:Protein

cso30:i:CC_Cytosol

--

p6

--

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
388.7187816809102, 739.7849091882362
442.38942844499235, 408.0227786834339

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
436.50013521873046, 749.4544558712146
258.6783622564761, 395.45534196833836

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
394.48549676306095, 745.2307984314442
430.85599828069115, 397.1310001970178

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
395.3093132033681, 746.0686275457838
429.2083654000764, 395.45534196833836

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
388.7187816809102, 739.7849091882362
442.38942844499235, 408.0227786834339

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
388.7187816809102, 739.7849091882362
442.38942844499235, 408.0227786834339

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
395.3093132033681, 746.0686275457838
429.2083654000764, 395.45534196833836

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
711.6548262813515, 907.3507320561762
27.638060778726306, 25.44529011197912

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
639.1589795343135, 1024.6468080637337
78.26256182918857, 72.05330383321423

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
388.7187816809102, 739.7849091882362
442.38942844499235, 408.0227786834339

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
444.5, 844.0
45.0, 24.0

Tissue factor

--

e6

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p6

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
492.9874808114133, 921.1068605151781
14.009823175868735, 6.860207237450749

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
492.51965315962343, 900.6480991414583
47.9523343084502, 87.78235984770473

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
512.6362421865833, 957.7423169285839
7.4852424286361225, 7.612562371616666

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
199.21080063798502, 50.845714370901305
797.7769714934396, 1149.6573565402728

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
202.06094147991897, 71.1360557910755
765.3169548808553, 1130.1418162113698

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
209.66131705840954, 91.42639721124974
761.8228631791528, 1115.3202894796739

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
333.0, 965.0
30.0, 30.0

p1

p1

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G000317 MO000016882

MO000017264

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c7 : 1
stoichiometry:c4 : 1

m87556*m155666*0.1

nodelay

--

true

0

false

PMID: 18031251 It has long been known that many cells respond to microbial stimuli such as LPS (lipopolysaccharide), lipoproteins and flagellin by the generation of neutrophil-recruiting chemokines such as IL-8 (interleukin-8).

Go back
332.0, 1006.0
30.0, 30.0

p2

p2

cso30:i:ME_Translation

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

G000317 MO000017793

MO000017264

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c2 : 1
stoichiometry:c8 : 1
stoichiometry:c5 : 1

m87556*m2549*0.1

nodelay

--

true

0

false

PMID: 18031251 It has long been known that many cells respond to microbial stimuli such as LPS (lipopolysaccharide), lipoproteins and flagellin by the generation of neutrophil-recruiting chemokines such as IL-8 (interleukin-8).

Go back
333.0, 1069.0
30.0, 30.0

p3

p3

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G000317 MO000022185

MO000017264

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c3 : 1
stoichiometry:c9 : 1
stoichiometry:c6 : 1

m87556*m6485*0.1

nodelay

--

true

0

false

PMID: 18031251 It has long been known that many cells respond to microbial stimuli such as LPS (lipopolysaccharide), lipoproteins and flagellin by the generation of neutrophil-recruiting chemokines such as IL-8 (interleukin-8).

Go back
333.0, 918.0
30.0, 30.0

p4

p4

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010389 MO000016882

MO000016597

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c11 : 1
stoichiometry:c12 : 1
stoichiometry:c10 : 1

m93364*m155666*0.1

nodelay

--

true

0

false

PMID: 18031251, 9670975 Of these, LPS was thought to be a potent stimulator of neutrophil survival, acting again via IL-1beta [39], since it was apparent that LPS-activated neutrophils were themselves a source of IL-1beta, which was an effective stimulator of survival in an autocrine fashion.

Go back
356.0, 789.0
30.0, 30.0

p5

p5

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

MO000016882 G010430

MO000000308

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c18 : 1

m155666*m93402*0.1

nodelay

--

true

0

false

PMID: 18031251, 1993838, 7504060 Such co-culture models have been employed previously to demonstrate that monocytes amplify prothrombotic responses to LPS {via production of TF (tissue factor) from endothelial cells [36]}, and can potentially enhance recruitment of other cells through the up-regulation of adhesion molecules such as VCAM (vascular cell adhesion molecule).

Go back
352.0, 841.0
30.0, 30.0

p6

p6

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e6 MO000016882

e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c15 : 1

m6*m155666*0.1

nodelay

--

true

0

false

PMID: 18031251, 1993838, 7504060 Such co-culture models have been employed previously to demonstrate that monocytes amplify prothrombotic responses to LPS {via production of TF (tissue factor) from endothelial cells [36]}, and can potentially enhance recruitment of other cells through the up-regulation of adhesion molecules such as VCAM (vascular cell adhesion molecule).

Go back
116.0, 826.0
30.0, 30.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e11 MO000016882

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1

m11*m155666*0.1

nodelay

--

true

0

false

PMID: 18031251, 17138954 In part, this is because of a variety of physical defence measures, including the trapping of particulate matter in larger airways by mucus and the ability of various airway-secreted molecules such as surfactant proteins to bind and neutralize LPS.

Go back
334.0, 1114.0
30.0, 30.0

p8

p8

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G000317 e13

MO000017264

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c24 : 1
stoichiometry:c22 : 1

m87556*m13*0.1

nodelay

--

true

0

false

PMID: 18031251, 1569186 Neutrophil proteases have the ability to further modify local responses, since they can digest CD14 and decrease LPS responsiveness of some cells, but may also generate IL-8 production from epithelial cells [55] or signal via TLR4.

Go back
370.5339352927587, 987.6906911759852

c1

c1

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
317.3365604500259, 919.1898088913156

c10

c10

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
370.9989923798688, 932.0

c11

c11

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
149.0, 910.0

c12

c12

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
149.0, 813.1898088913156

c13

c13

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
394.0, 804.0

c14

c14

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
334.0, 856.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
390.0, 856.0

c16

c16

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
149.0, 860.7313696155672

c17

c17

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
371.0, 764.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
129.0, 798.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
369.9898164372275, 1022.4035260826882

c2

c2

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
130.0, 863.9960966086966

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
85.99723135482277, 842.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
297.3379865726819, 1071.9586826857844

c22

c22

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
370.39208358269497, 1045.0

c23

c23

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
296.0, 1128.0

c24

c24

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
370.38015156544446, 1037.0

c3

c3

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
299.51724137931035, 995.0

c4

c4

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
301.2299027111483, 1028.0

c5

c5

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
301.2636750760036, 1062.352465419694

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
149.0, 914.0

c7

c7

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
151.0, 1018.0

c8

c8

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
153.0, 1084.0

c9

c9

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

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