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Indirect
Indirect
PMID: 18031251
It has long been known that many cells respond to microbial stimuli such as LPS (lipopolysaccharide), lipoproteins and flagellin by the generation of neutrophil-recruiting chemokines such as IL-8 (interleukin-8).
Indirect
Indirect
PMID: 18031251
It has long been known that many cells respond to microbial stimuli such as LPS (lipopolysaccharide), lipoproteins and flagellin by the generation of neutrophil-recruiting chemokines such as IL-8 (interleukin-8).
Indirect
Indirect
PMID: 18031251
It has long been known that many cells respond to microbial stimuli such as LPS (lipopolysaccharide), lipoproteins and flagellin by the generation of neutrophil-recruiting chemokines such as IL-8 (interleukin-8).
Indirect
Indirect
PMID: 18031251, 9670975
Of these, LPS was thought to be a potent stimulator of neutrophil survival, acting again via IL-1beta [39], since it was apparent that LPS-activated neutrophils were themselves a source of IL-1beta, which was an effective stimulator of survival in an autocrine fashion.
Indirect
Indirect
PMID: 18031251, 1993838, 7504060
Such co-culture models have been employed previously to demonstrate that monocytes amplify prothrombotic responses to LPS {via production of TF (tissue factor) from endothelial cells [36]}, and can potentially enhance recruitment of other cells through the up-regulation of adhesion molecules such as VCAM (vascular cell adhesion molecule).
Indirect
Indirect
PMID: 18031251, 1993838, 7504060
Such co-culture models have been employed previously to demonstrate that monocytes amplify prothrombotic responses to LPS {via production of TF (tissue factor) from endothelial cells [36]}, and can potentially enhance recruitment of other cells through the up-regulation of adhesion molecules such as VCAM (vascular cell adhesion molecule).
PMID: 18031251, 17138954
In part, this is because of a variety of physical defence measures, including the trapping of particulate matter in larger airways by mucus and the ability of various airway-secreted molecules such as surfactant proteins to bind and neutralize LPS.
Indirect
Indirect
PMID: 18031251, 1569186
Neutrophil proteases have the ability to further modify local responses, since they can digest CD14 and decrease LPS responsiveness of some cells, but may also generate IL-8 production from epithelial cells [55] or signal via TLR4.