majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:18031244.csml convertedTime:2009.07.01.11:10

Entity

MO000016882:LPS MO000019394:TLR4 MO000019397:TLR2 MO000044940:HMGB1 e1: e10: e11:biglycan e12:serum amyloid A e13:HMGB1: TLR2 e14:biglycan: TLR2 e15:hyaluronic acid fragments: TLR2 e16:serum amyloid A: TLR2 e17:Pam3CSK4 e18:Pam3CSK4: TLR2 e2: e3: e4: e5:LPS: TLR4 e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:hyaluronic acid fragments e60: e61: e62: e7: e8: e9:

Process

p1 p2 p3 p4 p5 p6
334.0, 14.0
30.0, 30.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
336.0, 88.0
32.0, 32.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
817.0, 421.0
30.0, 30.0

TLR2

--

MO000019397

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2 p3 p4 p5 p6

true true true true

csml-variable:Double

m3964

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019397

--

Go back
956.0, 368.0
31.0, 31.0

HMGB1

--

MO000044940

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m22603

10

false

infinite

0

unit false false false
TRANSPATHMO000044940

--

Go back
7.75, 74.99690800911759
856.2594311764528, 1243.2886940682085

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
16.0, 94.0
829.9775981223105, 1167.545103664102

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
953.5, 303.25
45.0, 25.5

biglycan

--

e11

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p4

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
957.5, 543.25
45.0, 25.5

serum amyloid A

--

e12

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p5

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
815.875, 361.5
32.25, 45.0

HMGB1: TLR2

--

e13

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p2

--

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
815.875, 293.5
32.25, 45.0

biglycan: TLR2

--

e14

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p4

--

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
815.875, 481.5
32.25, 45.0

hyaluronic acid fragments: TLR2

--

e15

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p3

--

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
815.875, 533.5
32.25, 45.0

serum amyloid A: TLR2

--

e16

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p5

--

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
949.5, 627.25
45.0, 25.5

Pam3CSK4

--

e17

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p6

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
811.875, 617.5
32.25, 45.0

Pam3CSK4: TLR2

--

e18

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p6

--

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
7.75, 74.99690800911759
856.2594311764528, 1243.2886940682085

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
24.875188623529027, 92.12209663264667
822.0090539293948, 1209.0383168211513

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
56.55678757705792, 122.09117672382234
758.6458560223374, 1149.1001566387988

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
459.625, 87.5
32.97762872854524, 40.38076987168805

LPS: TLR4

--

e5

cso30:c:Complex

cso30:i:CC_Cytosol

--

p1

--

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
189.0, 792.0
465.6500709748862, 422.29345356567933

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
239.29367619468036, 802.0077409313898
272.27955732982184, 409.2864683429171

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
195.06992643728904, 797.6363602631969
453.51021810030846, 411.0207330392853

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
195.93705878547314, 798.503492611381
451.7759534039399, 409.2864683429171

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
189.0, 792.0
465.6500709748862, 422.29345356567933

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
189.0, 792.0
465.6500709748862, 422.29345356567933

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
195.93705878547314, 798.503492611381
451.7759534039399, 409.2864683429171

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
528.9158804881849, 965.4264696368292
29.091257918298922, 26.33524401024959

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
452.6082338479803, 1086.8249983826097
82.37757307749382, 74.57338194383664

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
189.0, 792.0
465.6500709748862, 422.29345356567933

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
949.5, 463.25
45.0, 25.5

hyaluronic acid fragments

--

e6

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p3

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
298.7511016961721, 979.6637213250546
14.746453546866459, 7.100144300343119

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
298.25867587120234, 958.4894108513561
50.4736470593979, 90.85256470691624

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
319.43298634490145, 1017.5805098477247
7.878813199515761, 7.8788131995157675

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
19.0, 80.0
839.7237354966342, 1189.8668429177399

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
22.0, 101.0
805.5569854171277, 1169.6687428256696

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
30.0, 122.0
801.8791759029863, 1154.3288303559784

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
409.0, 33.0
30.0, 30.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016882 MO000019394

e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m155666*m3961*0.1

nodelay

--

true

0

false

PMID: 18031244, 12816876 Others had shown that administration of LPS (lipopolysaccharide), an exogenous TLR4 agonist, promoted disease in rabbits and mice.

Go back
891.0, 371.0
25.0, 25.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019397 MO000044940

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m3964*m22603*0.1

nodelay

--

true

0

false

PMID: 18031244, 16267105, 16025156, 11781369 Other possibilities include HMGB1 (high-mobility group B1), biglycan, hyaluronic acid fragments, necrotic cells and SAA (serum amyloid A) [31?36]. All of these have been shown to be TLR2 agonists in vitro.

Go back
891.0, 463.0
25.0, 25.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019397 e6

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m3964*m6*0.1

nodelay

--

true

0

false

PMID: 18031244, 16267105, 16025156, 11781369 Other possibilities include HMGB1 (high-mobility group B1), biglycan, hyaluronic acid fragments, necrotic cells and SAA (serum amyloid A) [31?36]. All of these have been shown to be TLR2 agonists in vitro.

Go back
887.0, 303.0
25.0, 25.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019397 e11

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m3964*m11*0.1

nodelay

--

true

0

false

PMID: 18031244, 16267105, 16025156, 11781369 Other possibilities include HMGB1 (high-mobility group B1), biglycan, hyaluronic acid fragments, necrotic cells and SAA (serum amyloid A) [31?36]. All of these have been shown to be TLR2 agonists in vitro.

Go back
894.0, 542.0
27.0, 27.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019397 e12

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m3964*m12*0.1

nodelay

--

true

0

false

PMID: 18031244, 16267105, 16025156, 11781369 Other possibilities include HMGB1 (high-mobility group B1), biglycan, hyaluronic acid fragments, necrotic cells and SAA (serum amyloid A) [31?36]. All of these have been shown to be TLR2 agonists in vitro.

Go back
886.0, 626.0
27.0, 27.0

p5

p6

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e17 MO000019397

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m17*m3964*0.1

nodelay

--

true

0

false

PMID: 18031244 the proatherogenic TLR2 responses to the defined synthetic exogenous agonist Pam3 CSK4 are mediated at least in part by BMDC, which can include lymphocytes, monocytes/macrophages and dendritic cells.

Go back
364.0, 33.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
847.0, 444.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
924.0, 476.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
855.4396857613915, 481.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
841.0, 451.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
929.0, 556.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
856.0, 556.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
921.0, 640.0

c14

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
837.0, 451.0

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
852.0, 640.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
368.0, 64.92216684322386

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
437.0, 63.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
847.0, 397.70537358140035

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
924.0, 384.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
856.0, 384.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
840.0, 334.9505396729682

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
920.0, 316.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
856.0, 316.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back