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PMID: 18022390
Here, we are focusing on PPAR-gamma and liver X receptor (LXR) since they have been shown to play a substantial role in lesion macrophages during atherosclerosis. Both of them form heterodimer with a common partner, retinoid X receptor (RXR).</csml:comment>
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PMID: 18022390
Here, we are focusing on PPAR-gamma and liver X receptor (LXR) since they have been shown to play a substantial role in lesion macrophages during atherosclerosis. Both of them form heterodimer with a common partner, retinoid X receptor (RXR).</csml:comment>
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PMID: 18022390, 9568716
Oxidized but not native LDL promotes its own uptake via scavenger receptor CD36 by PPAR-gamma.</csml:comment>
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PMID: 18022390, 9568716
Oxidized but not native LDL promotes its own uptake via scavenger receptor CD36 by PPAR-gamma.

PMID: 18022390, 9568715
Two components from oxLDL, 9-hydroxy octadecadienoic acid (9-HODE) and 13-HODE were identified as endogenous activators and bona fide ligands for PPAR-gamma.</csml:comment>
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PMID: 18022390
the consequence of oxLDL internalization is the activation of PPAR-gamma that enhances further expression of CD36.

PMID: 18022390
There is no change in the mRNA level of CD36 when PPAR-gamma-deficient macrophages are treated with synthetic agonists such as thiazolidinediones (TZDs).</csml:comment>
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Indirect</csml:comment>
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PMID: 18022390, 11172721
As detailed above, PPAR-gamma enhances uptake of its own ligand via oxLDL but it can also induce cholesterol efflux from macrophages via several mechanisms. An important one is the induction of another nuclear receptor, LXR-alpha, which in turn activates expression of a set of genes involved in cholesterol efflux and transport.

PMID: 18022390, 16461908
AEBP1 overexpression in macrophages is accompanied by decreased expression of PPAR-gamma, LXR-greek small letter alpha and their target genes with concomitant elevation of pro-inflammatory cytokines.</csml:comment>
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</csml:comment>
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<csml:comment type="text">


PMID: 18022390, 11504730, 9794827, 8878485
A number of oxysterols were identified as potential endogenous ligands for LXR.</csml:comment>
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Indirect</csml:comment>
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</csml:comment>
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<csml:comment type="text">


PMID: 18022390, 11035776
Among LXR target genes there are lipid transporters, such as ABCA1 and ABCG1, members of the ATP-binding cassette family of transporter proteins that are likely to be responsible for cholesterol efflux.</csml:comment>
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PMID: 18022390, 11035776
Among LXR target genes there are lipid transporters, such as ABCA1 and ABCG1, members of the ATP-binding cassette family of transporter proteins that are likely to be responsible for cholesterol efflux.</csml:comment>
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PMID: 18022390, 10968783, 10858438 , 10799558
Several studies reported that LXRs mediate cholesterol efflux by inducing cholesterol transporters ABCA1, ABCG1 and later ABCG5 and ABCG8.</csml:comment>
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PMID: 18022390, 10968783, 10858438 , 10799558
Several studies reported that LXRs mediate cholesterol efflux by inducing cholesterol transporters ABCA1, ABCG1 and later ABCG5 and ABCG8.</csml:comment>
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PMID: 18022390, 2722778, 9660774
One of these, 27-hydroxycholesterol is produced by a p450 enzyme CYP27, which is a mitochondrial enzyme involved in alternative bile acid synthesis.</csml:comment>
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PMID: 18022390
A number of oxysterols were identified as potential endogenous ligands for LXR. One of these, 27-hydroxycholesterol is produced by a p450 enzyme CYP27.</csml:comment>
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PMID: 18022390, 15340076
We found that retinoid receptors and PPAR-gamma induce the expression of CYP27 resulting in increased production 27-hydroxycholesterol in macrophages which activates LXR and enhances cholesterol efflux from macrophages through ABC transporters.

PMID: 18022390, 15340076
CYP27 can be induced by retinoids and PPAR-&#947; only in human macrophages</csml:comment>
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PMID: 18022390, 15340076
We found that retinoid receptors and PPAR-gamma induce the expression of CYP27 resulting in increased production 27-hydroxycholesterol in macrophages which activates LXR and enhances cholesterol efflux from macrophages through ABC transporters.</csml:comment>
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PMID: 18022390
PPAR-gamma can both directly and indirectly (through LXR) induce transcription of ABCG1.</csml:comment>
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PMID: 18022390, 15479645
AIM is regulated by LXR only in mice.</csml:comment>
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PMID: 18022390, 12540828
PPAR-beta/theta functions as a sensor for VLDL and promotes VLDL-derived fatty acid catabolism.</csml:comment>
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PMID: 18022390
Development of macrophages is driven by monocyte colony-stimulating factor (M-CSF). It also augments SR-A, cytokine and growth factor expression and serves as a survival stimulus.</csml:comment>
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PMID: 18022390
Development of macrophages is driven by monocyte colony-stimulating factor (M-CSF). It also augments SR-A, cytokine and growth factor expression and serves as a survival stimulus.

PMID: 18022390, 9422508
As detailed above, PPAR-gamma was reported to upregulate expression of scavenger receptor CD36 and downregulate SR-A in macrophages.</csml:comment>
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PMID: 18022390, 16873730
At the same time GM-CSF deficiency reduces PPAR-gamma expression and aggravates atherosclerosis in ApoE knockout mice.</csml:comment>
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Indirect</csml:comment>
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PMID: 18022390, 16873730
At the same time GM-CSF deficiency reduces PPAR-gamma expression and aggravates atherosclerosis in ApoE knockout mice.

PMID: 18022390, 16461908
AEBP1 overexpression in macrophages is accompanied by decreased expression of PPAR-gamma, LXR-greek small letter alpha and their target genes with concomitant elevation of pro-inflammatory cytokines.</csml:comment>
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PMID: 18022390, 17435771
MIF has been reported recently as a ligand for chemokine receptors CXCR2 and CXCR4 that control leukocyte recruitment during atherogenesis.</csml:comment>
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PMID: 18022390, 17435771
MIF has been reported recently as a ligand for chemokine receptors CXCR2 and CXCR4 that control leukocyte recruitment during atherogenesis.</csml:comment>
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PMID: 18022390, 15947238, 10995790, 15896316 
PPAR-gamma represses transcription of MCP-1 and its receptor CCR2 in macrophages regulating recruitment of these cells to inflammatory loci in the colon.</csml:comment>
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PMID: 18022390, 15947238, 10995790, 15896316 
PPAR-gamma represses transcription of MCP-1 and its receptor CCR2 in macrophages regulating recruitment of these cells to inflammatory loci in the colon.</csml:comment>
</csml:comments>
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<csml:comment type="text">


PMID: 18022390, 11861414, 14581413, 15331403
SR-B1 is expressed in the liver and also in macrophages. It binds HDL, LDL, modified LDL and if knocked out, atherosclerosis is increased in ApoE-deficient or LDLR-deficient mice.</csml:comment>
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PMID: 18022390
As a result macrophages take up oxLDL via scavenger receptors (SR) and start to produce metalloproteinases (MMPs), cytokines and reactive oxygen species (ROS).</csml:comment>
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PMID: 18022390
As a result macrophages take up oxLDL via scavenger receptors (SR) and start to produce metalloproteinases (MMPs), cytokines and reactive oxygen species (ROS).</csml:comment>
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PMID: 18022390
As a result macrophages take up oxLDL via scavenger receptors (SR) and start to produce metalloproteinases (MMPs), cytokines and reactive oxygen species (ROS).</csml:comment>
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PMID: 18022390
As a result macrophages take up oxLDL via scavenger receptors (SR) and start to produce metalloproteinases (MMPs), cytokines and reactive oxygen species (ROS).</csml:comment>
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PMID: 18022390
As a result macrophages take up oxLDL via scavenger receptors (SR) and start to produce metalloproteinases (MMPs), cytokines and reactive oxygen species (ROS).</csml:comment>
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PMID; 18022390, 16007265
PPAR-gamma was also reported to induce oxLDL receptor-1 in adipocytes resulting in increased uptake of the lipoprotein.</csml:comment>
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PMID: 18022390, 9244201, 9050882, 9671306
Binding of CD40 ligand to its receptor CD154 induces inflammatory response along with expression of pro-inflammatory cytokines, MMPs, adhesion molecules and tissue factor while inhibition of CD40 ligation reduces plaque size.</csml:comment>
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PMID: 18022390, 9244201, 9050882, 9671306
Binding of CD40 ligand to its receptor CD154 induces inflammatory response along with expression of pro-inflammatory cytokines, MMPs, adhesion molecules and tissue factor while inhibition of CD40 ligation reduces plaque size.</csml:comment>
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PMID: 18022390, 10432118
IL-4 induces expression of PPAR-gamma.</csml:comment>
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PMID: 18022390, 10432118
IL-4 induces expression of PPAR-gamma.

PMID: 18022390, 16461908
AEBP1 overexpression in macrophages is accompanied by decreased expression of PPAR-gamma, LXR-greek small letter alpha and their target genes with concomitant elevation of pro-inflammatory cytokines.</csml:comment>
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PMID: 18022390, 12524534
It was shown recently, that activation of LXR inhibits secretion of pro-inflammatory molecules like inducible nitric oxide synthase, IL-6, IL-1beta, TNF-alpha.</csml:comment>
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PMID: 18022390, 12524534
It was shown recently, that activation of LXR inhibits secretion of pro-inflammatory molecules like inducible nitric oxide synthase, IL-6, IL-1beta, TNF-alpha.</csml:comment>
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PMID: 18022390, 12524534
It was shown recently, that activation of LXR inhibits secretion of pro-inflammatory molecules like inducible nitric oxide synthase, IL-6, IL-1beta, TNF-alpha.</csml:comment>
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PMID: 18022390, 16611854
PPAR-gamma can repress TGF-beta1 gene through induction of phosphatase and tensin homologue deleted on chromosome 10 (PTEN).</csml:comment>
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PMID: 18022390, 12588772
It inhibits expression of MMP-9.

PMID: 18022390, 12531895
Interestingly, LXR can also repress MMP-9 expression.</csml:comment>
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PMID: 18022390, 17255360
LXR also alters DC phenotype by decreasing IL-12, increasing IL-10 secretion and blocking its T-cell stimulatory ability.</csml:comment>
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PMID: 18022390, 17255360
LXR also alters DC phenotype by decreasing IL-12, increasing IL-10 secretion and blocking its T-cell stimulatory ability.</csml:comment>
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PMID: 18022390, 15345223, 16982809
PPAR-gamma via induction of retinoic acid synthesis induces CD1d expression in DCs resulting in NKT cell proliferation and possibly altered lipid presentation by CD1 molecules.</csml:comment>
</csml:comments>
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PMID: 18022390, 15345223, 16982809
PPAR-gamma via induction of retinoic acid synthesis induces CD1d expression in DCs resulting in NKT cell proliferation and possibly altered lipid presentation by CD1 molecules.</csml:comment>
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PMID: 18022390, 15345223, 16982809
PPAR-gamma via induction of retinoic acid synthesis induces CD1d expression in DCs resulting in NKT cell proliferation and possibly altered lipid presentation by CD1 molecules.</csml:comment>
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PMID: 18022390, 16611854
PPAR-gamma can repress TGF-beta1 gene through induction of phosphatase and tensin homologue deleted on chromosome 10 (PTEN).</csml:comment>
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Indirect</csml:comment>
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PMID: 18022390, 16611854
PPAR-gamma can repress TGF-beta1 gene through induction of phosphatase and tensin homologue deleted on chromosome 10 (PTEN).</csml:comment>
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PMID: 18022390
PPARs and LXRs are activated by fatty acids, oxLDL, arachidonic acid metabolites like eicosanoids, prostaglandins, leukotriens and oxidized cholesterol, respectively.</csml:comment>
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PMID: 18022390
PPARs and LXRs are activated by fatty acids, oxLDL, arachidonic acid metabolites like eicosanoids, prostaglandins, leukotriens and oxidized cholesterol, respectively.</csml:comment>
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PMID: 18022390
PPARs and LXRs are activated by fatty acids, oxLDL, arachidonic acid metabolites like eicosanoids, prostaglandins, leukotriens and oxidized cholesterol, respectively.</csml:comment>
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