_enti_e7
_enti_e8
_enti_e9
_enti_e1
_enti_e3
_enti_e2
_enti_e4
_enti_e55
_enti_e53
_enti_e59
_enti_e56
_enti_e52
_enti_e54
_enti_e51
_enti_e50
_enti_e57
_enti_e61
_enti_e58
_enti_e60
_enti_e62
g1_fact_g1
g1_fact_g14
g2_fact_g12
g2_fact_g13
p1_propro_p1
PMID: 17981503,15629253,15860371
They form heterodimers with the retinoid X receptor (RXR) and activate transcription by binding to a specific DNA element termed the PPAR response element (PPRE)
c2 cso30:c:InputProcess connector
c1 cso30:c:InputProcess connector
c3 cso30:c:OutputProcess connector
p2_propro_p2
PMID: 17981503, 15629253, 15860371
They form heterodimers with the retinoid X receptor (RXR) and activate transcription by binding to a specific DNA element termed the PPAR response element (PPRE)
c4 cso30:c:InputProcess connector
c5 cso30:c:InputProcess connector
c6 cso30:c:OutputProcess connector
p3_propro_p3
PMID: 17981503,12110006,17631136
For example, the PPARγ ligand troglitazone increased expression of the chemokine MCP-1 (CCL2) and enhanced monocyte/macrophage infiltration in a rat model of glomerulonephritis, and the PPARδ ligand GW0742 worsened the course of colitis in IL-10-deficient mice
c7 cso30:c:InputProcess connector
c8 cso30:c:InputProcess connector
c9 cso30:c:OutputProcess connector
p4_propro_p4
PMID: 17981503,12110006,17631136
For example, the PPARgamma ligand troglitazone increased expression of the chemokine MCP-1 (CCL2) and enhanced monocyte/macrophage infiltration in a rat model of glomerulonephritis, and the PPARdelta ligand GW0742 worsened the course of colitis in IL-10-deficient mice
c10 cso30:c:InputAssociation connector
c11 cso30:c:OutputProcess connector
p5_propro_p5
PMID: 17981503,12110006,17631136
For example, the PPARgamma ligand troglitazone increased expression of the chemokine MCP-1 (CCL2) and enhanced monocyte/macrophage infiltration in a rat model of glomerulonephritis, and the PPARδ ligand GW0742 worsened the course of colitis in IL-10-deficient mice
c12 cso30:c:InputProcess connector
c13 cso30:c:InputProcess connector
p6_propro_p6
PMID:17981503,16127449
Repression of lipopolysaccharide (LPS)-induced iNOS (NOS2) gene expression in macrophages has been characterized in detail
c29 cso30:c:InputAssociation connector
c15 cso30:c:OutputProcess connector
p7_propro_p7
PMID: 17981503
In the “off” state, the iNOS gene is actively repressed by a multisubunit complex containing NCoR, histone deacetylase 3 (HDAC3), TBL1, and TBLR1.
c17 cso30:c:InputInhibitor connector
c18 cso30:c:InputProcess connector
c16 cso30:c:OutputProcess connector
p8_propro_p8
PMID: 17981503
When LPS binds to TLR4, the NF-KappaB signaling pathway is activated, IKappaB is degraded, and NF-KappaB p65-p50 heterodimers enter the nucleus.
c14 cso30:c:InputProcess connector
c19 cso30:c:InputProcess connector
c20 cso30:c:OutputProcess connector
p9_propro_p9
PMID: 17981503
When LPS binds to TLR4, the NF-KappaB signaling pathway is activated, IKappaB is degraded, and NF-KappaB p65-p50 heterodimers enter the nucleus.
c21 cso30:c:InputAssociation connector
c22 cso30:c:InputProcess connector
c23 cso30:c:OutputProcess connector
p10_propro_p10
PMID: 17981503
When LPS binds to TLR4, the NF-KappaB signaling pathway is activated, IKappaB is degraded, and NF-KappaB p65-p50 heterodimers enter the nucleus.
c24 cso30:c:InputProcess connector
c25 cso30:c:OutputProcess connector
c26 cso30:c:OutputProcess connector
p11_propro_p11
PMID: 17981503
When LPS binds to TLR4, the NF-KappaB signaling pathway is activated, IKappaB is degraded, and NF-KappaB p65-p50 heterodimers enter the nucleus.
c27 cso30:c:InputProcess connector
c28 cso30:c:OutputProcess connector
p12_propro_p12
PMID: 17981503
Concomitant with these events, the corepressor complex is ubiquitinated and degraded by the 19 S proteasome.
c30 cso30:c:InputProcess connector
c31 cso30:c:InputAssociation connector
c32 cso30:c:OutputProcess connector
p13_propro_p13
PMID: 17981503
Concomitant with these events, the corepressor complex is ubiquitinated and degraded by the 19 S proteasome.
c33 cso30:c:InputProcess connector
c34 cso30:c:OutputProcess connector
p14_propro_p14
PMID: 17981503
NF-KappaB p65-p50 heterodimers bind to the KappaB element located in the iNOS promoter, facilitating the recruitment of coactivator complexes and activation of iNOS gene transcription.
c35 cso30:c:InputProcess connector
c36 cso30:c:InputProcess connector
c37 cso30:c:OutputProcess connector
p15_propro_p15
PMID: 17981503
NF-KappaB p65-p50 heterodimers bind to the KappaB element located in the iNOS promoter, facilitating the recruitment of coactivator complexes and activation of iNOS gene transcription.
c38 cso30:c:InputProcess connector
c39 cso30:c:InputProcess connector
c40 cso30:c:OutputProcess connector
p16_propro_p16
PMID: 17981503
NF-KappaB p65-p50 heterodimers bind to the KappaB element located in the iNOS promoter, facilitating the recruitment of coactivator complexes and activation of iNOS gene transcription.
c41 cso30:c:InputAssociation connector
c42 cso30:c:OutputProcess connector
p18_propro_p18
PMID: 17981503
In cells treated with PPARgamma ligand plus LPS, ligand binding triggers conjugation of a small fraction of cellular PPARgamma with SUMO1 (small ubiquitin-like modifier) on lysine 365 (K365), mediated by the SUMOylation pathway E2 ligase Ubc9 and E3 ligase PIAS1
PMID: 17981503
Figure 2
c43 cso30:c:InputProcess connector
c44 cso30:c:InputProcess connector
c46 cso30:c:InputAssociation connector
c47 cso30:c:InputAssociation connector
c48 cso30:c:InputAssociation connector
c45 cso30:c:OutputProcess connector
p17_propro_p17
PMID: 17981503,16127449
The SUMOylated PPARgamma binds to NCoR and interferes with clearance of the corepressor complex, thereby maintaining the promoter in the repressed state
c49 cso30:c:InputProcess connector
c50 cso30:c:InputProcess connector
c51 cso30:c:OutputProcess connector
p19_propro_p19
PMID: 17981503
SUMOylation of PPARgamma is predicted to prevent its heterodimerization with RXR, thereby dedicating this form of PPARgamma to a repressor function.
c52 cso30:c:InputProcess connector
c53 cso30:c:InputProcess connector
c55 cso30:c:InputInhibitor connector
c54 cso30:c:OutputProcess connector
p20_propro_p20
PMID: 17981503,12970571
Binding of ligand to PPARdelta releases BCL-6, which then represses inflammatory-response genes
PMID: 17981503,17218271
The liver X receptors (LXRalpha and -beta) repress a subset of inflammatory-response genes that overlaps with, yet is distinct from, the subset repressed by PPARgamma
c66 cso30:c:InputInhibitor connector
c68 cso30:c:InputInhibitor connector
c69 cso30:c:InputInhibitor connector
c67 cso30:c:OutputProcess connector
p21_propro_p21
PMID: 17981503,10542237
Direct binding of PPARalpha to NF-KappaB p65 was demonstrated by in vitro assays, suggesting that transrepression might involve direct interference with transcriptional activation by NF-KappaB
c56 cso30:c:InputProcess connector
c57 cso30:c:InputProcess connector
c58 cso30:c:OutputProcess connector
p22_propro_p22
PMID: 17981503
For PPARdelta, a novel mechanism for transrepression was identified that involves binding and sequestration of the transcriptional repressor BCL-6 by unliganded PPARdelta.
c59 cso30:c:InputProcess connector
c60 cso30:c:InputProcess connector
c61 cso30:c:OutputProcess connector
p23_propro_p23
PMID: 17981503,12970571
Binding of ligand to PPARdelta releases BCL-6, which then represses inflammatory-response genes
c62 cso30:c:InputProcess connector
c63 cso30:c:InputProcess connector
c64 cso30:c:OutputProcess connector
c65 cso30:c:OutputProcess connector
p24_propro_p24
PMID: 17981503
Binding of ligand to the LXRs triggers covalent conjugation with SUMO2 and -3.
c70 cso30:c:InputProcess connector
c71 cso30:c:InputProcess connector
c72 cso30:c:OutputProcess connector
p24_propro_p25
PMID: 17981503
Binding of ligand to the LXRs triggers covalent conjugation with SUMO2 and -3.
c73 cso30:c:InputProcess connector
c74 cso30:c:InputProcess connector
c75 cso30:c:OutputProcess connector
p26_propro_p26
PMID: 17981503
Binding of ligand to the LXRs triggers covalent conjugation with SUMO2 and -3
PMID: 17981503
Here, the E3 ligase is HDAC4 rather than PIAS1.
c76 cso30:c:InputProcess connector
c77 cso30:c:InputProcess connector
c78 cso30:c:InputProcess connector
c79 cso30:c:InputAssociation connector
c80 cso30:c:InputAssociation connector
c81 cso30:c:OutputProcess connector
p27_propro_p27
PMID: 17981503
As with PPARgamma, SUMOylated LXR interferes with clearance of NCoR-containing corepressor complexes from the promoters of target genes.
c82 cso30:c:InputProcess connector
c83 cso30:c:InputProcess connector
c84 cso30:c:OutputProcess connector
p26_propro_p28
PMID: 17981503
Binding of ligand to the LXRs triggers covalent conjugation with SUMO2 and -3
PMID: 17981503
Here, the E3 ligase is HDAC4 rather than PIAS1.
c85 cso30:c:InputProcess connector
c86 cso30:c:InputProcess connector
c87 cso30:c:InputProcess connector
c88 cso30:c:InputAssociation connector
c89 cso30:c:InputAssociation connector
c90 cso30:c:OutputProcess connector
p27_propro_p29
PMID: 17981503
As with PPARgamma, SUMOylated LXR interferes with clearance of NCoR-containing corepressor complexes from the promoters of target genes.
c91 cso30:c:InputProcess connector
c92 cso30:c:InputProcess connector
c93 cso30:c:OutputProcess connector
p30_propro_p30
PMID: 17981503,16127449,17072333
Ligand-bound GR interacts strongly with the p65 subunit of NF-KappaB, in contrast to ligand-bound PPARgamma, which interacts very weakly with p65
c94 cso30:c:InputProcess connector
c95 cso30:c:InputProcess connector
c96 cso30:c:OutputProcess connector
c99 cso30:c:OutputProcess connector
p30_propro_p31
PMID: 17981503,16127449,17072333
Ligand-bound GR interacts strongly with the p65 subunit of NF-KappaB, in contrast to ligand-bound PPARgamma, which interacts very weakly with p65
c97 cso30:c:InputProcess connector
c98 cso30:c:InputProcess connector
p32_propro_p32
PMID: 17981503,15879558
Interestingly, repression by GR of tumor necrosis factor (TNF)-stimulated gene transcription in A549 lung adenocarcinoma cells is also target-gene specific: some NF-KappaB-dependent genes such as IL-8 (CXCL8) are repressed, whereas others, such as IKappaBalpha, are not
c100 cso30:c:InputAssociation connector
c102 cso30:c:InputAssociation connector
c103 cso30:c:InputInhibitor connector
c101 cso30:c:OutputProcess connector
p33_propro_p33
PMID: 17981503,10542237,14609950
In the case of AP-1, several mechanisms for transrepression by nuclear receptors have been identified, including inhibition of c-Jun N-terminal kinase (JNK) signaling by GR, and direct interaction of PPARalpha with c-Jun, resulting in interference with transcriptional activation
c104 cso30:c:InputProcess connector
c105 cso30:c:InputProcess connector
c106 cso30:c:OutputProcess connector
p34_propro_p34
PMID: 17981503,12133943,17475839,17277116
PPARgamma ligands inhibit DC maturation and repress the expression by DC of CD1a, CD40, CD83, CCR7, and the costimulatory molecule CD80 (B7.1)
c107 cso30:c:InputInhibitor connector
c108 cso30:c:OutputProcess connector
p34_propro_p35
PMID: 17981503,12133943,17475839,17277116
PPARgamma ligands inhibit DC maturation and repress the expression by DC of CD1a, CD40, CD83, CCR7, and the costimulatory molecule CD80 (B7.1)
c109 cso30:c:InputInhibitor connector
c110 cso30:c:OutputProcess connector
p34_propro_p36
PMID: 17981503,12133943,17475839,17277116
PPARgamma ligands inhibit DC maturation and repress the expression by DC of CD1a, CD40, CD83, CCR7, and the costimulatory molecule CD80 (B7.1)
c111 cso30:c:InputInhibitor connector
c112 cso30:c:OutputProcess connector
p34_propro_p37
PMID: 17981503,12133943,17475839,17277116
PPARgamma ligands inhibit DC maturation and repress the expression by DC of CD1a, CD40, CD83, CCR7, and the costimulatory molecule CD80 (B7.1)
c113 cso30:c:InputInhibitor connector
c114 cso30:c:OutputProcess connector
p38_propro_p38
PMID: 17981503,12133943,17192567
PPARgamma ligands also repress DC production of IL-12 and several chemokines, including CXCL10 and RANTES
c115 cso30:c:InputAssociation connector
c119 cso30:c:InputInhibitor connector
c116 cso30:c:OutputProcess connector
p38_propro_p39
PMID: 17981503,12133943,17192567
PPARgamma ligands also repress DC production of IL-12 and several chemokines, including CXCL10 and RANTES
c117 cso30:c:InputAssociation connector
c120 cso30:c:InputInhibitor connector
c118 cso30:c:OutputProcess connector
p38_propro_p40
PMID: 17981503,12133943,17192567
PPARgamma ligands also repress DC production of IL-12 and several chemokines, including CXCL10 and RANTES
c121 cso30:c:InputAssociation connector
c123 cso30:c:InputInhibitor connector
c122 cso30:c:OutputProcess connector
p41_propro_p41
PMID: 17981503,11934839
The PPARalpha ligand fenofibrate represses IFNgamma expression in anti-CD3-treated cultured human CD4+ lymphocytes
c124 cso30:c:InputProcess connector
c125 cso30:c:InputProcess connector
c126 cso30:c:OutputProcess connector
p42_propro_p42
c127 cso30:c:InputInhibitor connector
c132 cso30:c:InputInhibitor connector
c128 cso30:c:OutputProcess connector
p43_propro_p43
PMID: 17981503,11884448
Similarly, another PPARalpha ligand, Wy14643, represses IFNgamma in activated mouse splenocytes
c129 cso30:c:InputProcess connector
c130 cso30:c:InputProcess connector
c131 cso30:c:OutputProcess connector
p44_propro_p44
PMID: 17981503,17631136
More recently, fenofibrate has been shown to repress IL-17 expression in cultured splenocytes activated by PMA plus ionomycin and by Th17 cells in a pathogenic CD4+ T-cell line cultured from C3H Bir mice treated with cecal bacterial antigens
c133 cso30:c:InputInhibitor connector
c134 cso30:c:OutputProcess connector
p45_propro_p45
PMID: 17981503
Expression of the adhesion molecules ICAM-1, and -2, and VCAM-1 is induced by proinflammatory cytokines, including TNFalpha.
PMID: 17981503,10377075,16115476,16439686
PPARalpha is expressed in vascular endothelial cells, and PPARalpha ligands repress TNFalpha-elicited expression of VCAM-1 by these cells
c139 cso30:c:InputAssociation connector
c136 cso30:c:OutputProcess connector
p45_propro_p46
PMID: 17981503
Expression of the adhesion molecules ICAM-1, and -2, and VCAM-1 is induced by proinflammatory cytokines, including TNFalpha.
PMID: 17981503,10377075,16115476,16439686
PPARalpha is expressed in vascular endothelial cells, and PPARalpha ligands repress TNFalpha-elicited expression of VCAM-1 by these cells
c140 cso30:c:InputAssociation connector
c138 cso30:c:OutputProcess connector
p45_propro_p47
PMID: 17981503
Expression of the adhesion molecules ICAM-1, and -2, and VCAM-1 is induced by proinflammatory cytokines, including TNFalpha.
PMID: 17981503,10377075,16115476,16439686
PPARalpha is expressed in vascular endothelial cells, and PPARalpha ligands repress TNFalpha-elicited expression of VCAM-1 by these cells
c135 cso30:c:InputInhibitor connector
c141 cso30:c:InputAssociation connector
c137 cso30:c:OutputProcess connector
p48_propro_p48
PMID: 17981503,16798734
Interestingly, the proinflammatory cytokine IL-17 induces CXCL8 gene transcription and also stabilizes CXCL8 mRNA via a p38 MAP kinase-dependent pathway
c142 cso30:c:InputAssociation connector
c143 cso30:c:OutputProcess connector
p50_propro_p50
PMID: 17981503,16143103
In a recent microarray survey of genes highly induced by LPS in mouse macrophages, the PPARgamma ligand GW7845 repressed expression of several chemokine genes, including those encoding CXCL1, -9, and -10 as well as CCL2, -4, -7, -12, -17, and -19, by >40%.
c145 cso30:c:InputProcess connector
c146 cso30:c:InputProcess connector
c147 cso30:c:OutputProcess connector
p51_propro_p51
PMID: 17981503,16143103
In a recent microarray survey of genes highly induced by LPS in mouse macrophages, the PPARgamma ligand GW7845 repressed expression of several chemokine genes, including those encoding CXCL1, -9, and -10 as well as CCL2, -4, -7, -12, -17, and -19, by >40%.
c148 cso30:c:InputInhibitor connector
c153 cso30:c:InputAssociation connector
c149 cso30:c:OutputProcess connector
p51_propro_p52
PMID: 17981503,16143103
In a recent microarray survey of genes highly induced by LPS in mouse macrophages, the PPARgamma ligand GW7845 repressed expression of several chemokine genes, including those encoding CXCL1, -9, and -10 as well as CCL2, -4, -7, -12, -17, and -19, by >40%.
c150 cso30:c:InputInhibitor connector
c152 cso30:c:InputAssociation connector
c151 cso30:c:OutputProcess connector
p51_propro_p49
PMID: 17981503,16143103
In a recent microarray survey of genes highly induced by LPS in mouse macrophages, the PPARgamma ligand GW7845 repressed expression of several chemokine genes, including those encoding CXCL1, -9, and -10 as well as CCL2, -4, -7, -12, -17, and -19, by >40%.
PMID: 17981503,17486092
For example, in chronic inflammatory diseases perpetuated by effector T cells, activated Th1 cells are attracted to the site of inflammation by chemokines that interact with the CXCR3 receptor, including CXCL9, -10, and -11
PMID: 17981503,11208713
Expression of these chemokines is highly induced by the combination of IFNgamma and TNFalpha
c144 cso30:c:InputAssociation connector
c155 cso30:c:InputInhibitor connector
c154 cso30:c:OutputProcess connector
p51_propro_p53
PMID: 17981503,16143103
In a recent microarray survey of genes highly induced by LPS in mouse macrophages, the PPARgamma ligand GW7845 repressed expression of several chemokine genes, including those encoding CXCL1, -9, and -10 as well as CCL2, -4, -7, -12, -17, and -19, by >40%.
c156 cso30:c:InputAssociation connector
c158 cso30:c:InputInhibitor connector
c157 cso30:c:OutputProcess connector
p51_propro_p54
PMID: 17981503,16143103
In a recent microarray survey of genes highly induced by LPS in mouse macrophages, the PPARgamma ligand GW7845 repressed expression of several chemokine genes, including those encoding CXCL1, -9, and -10 as well as CCL2, -4, -7, -12, -17, and -19, by >40%.
c160 cso30:c:InputAssociation connector
c161 cso30:c:InputInhibitor connector
c159 cso30:c:OutputProcess connector
p51_propro_p55
PMID: 17981503,16143103
In a recent microarray survey of genes highly induced by LPS in mouse macrophages, the PPARgamma ligand GW7845 repressed expression of several chemokine genes, including those encoding CXCL1, -9, and -10 as well as CCL2, -4, -7, -12, -17, and -19, by >40%.
c162 cso30:c:InputInhibitor connector
c163 cso30:c:InputAssociation connector
c164 cso30:c:OutputProcess connector
p51_propro_p56
PMID: 17981503,16143103
In a recent microarray survey of genes highly induced by LPS in mouse macrophages, the PPARgamma ligand GW7845 repressed expression of several chemokine genes, including those encoding CXCL1, -9, and -10 as well as CCL2, -4, -7, -12, -17, and -19, by >40%.
c166 cso30:c:InputInhibitor connector
c167 cso30:c:InputAssociation connector
c165 cso30:c:OutputProcess connector
p51_propro_p57
PMID: 17981503,16143103
In a recent microarray survey of genes highly induced by LPS in mouse macrophages, the PPARgamma ligand GW7845 repressed expression of several chemokine genes, including those encoding CXCL1, -9, and -10 as well as CCL2, -4, -7, -12, -17, and -19, by >40%.
c168 cso30:c:InputAssociation connector
c170 cso30:c:InputInhibitor connector
c169 cso30:c:OutputProcess connector
p51_propro_p58
PMID: 17981503,16143103
In a recent microarray survey of genes highly induced by LPS in mouse macrophages, the PPARgamma ligand GW7845 repressed expression of several chemokine genes, including those encoding CXCL1, -9, and -10 as well as CCL2, -4, -7, -12, -17, and -19, by >40%.
c172 cso30:c:InputInhibitor connector
c173 cso30:c:InputAssociation connector
c171 cso30:c:OutputProcess connector
p59_propro_p59
PMID: 17981503,17631136
The PPARalpha ligands fenofibrate and GW7647 also repress CXCL10 mRNA expression and promoter activity in human HT-29 cells, a model for colonic epithelial cells
c174 cso30:c:InputInhibitor connector
c179 cso30:c:InputInhibitor connector
c175 cso30:c:OutputProcess connector
p60_propro_p60
PMID: 17981503,17631136
The PPARalpha ligands fenofibrate and GW7647 also repress CXCL10 mRNA expression and promoter activity in human HT-29 cells, a model for colonic epithelial cells
c176 cso30:c:InputProcess connector
c177 cso30:c:InputProcess connector
c178 cso30:c:OutputProcess connector
p61_propro_p61
PMID: 17981503,17486092
For example, in chronic inflammatory diseases perpetuated by effector T cells, activated Th1 cells are attracted to the site of inflammation by chemokines that interact with the CXCR3 receptor, including CXCL9, -10, and -11
c181 cso30:c:InputProcess connector
c182 cso30:c:InputProcess connector
c183 cso30:c:OutputProcess connector
p51_propro_p62
PMID: 17981503,17486092
For example, in chronic inflammatory diseases perpetuated by effector T cells, activated Th1 cells are attracted to the site of inflammation by chemokines that interact with the CXCR3 receptor, including CXCL9, -10, and -11
PMID: 17981503,11208713
Expression of these chemokines is highly induced by the combination of IFNgamma and TNFalpha
c180 cso30:c:InputAssociation connector
c184 cso30:c:InputAssociation connector
c185 cso30:c:OutputProcess connector
p51_propro_p63
PMID: 17981503,11208713
Expression of these chemokines is highly induced by the combination of IFNgamma and TNFalpha
c187 cso30:c:InputAssociation connector
c188 cso30:c:InputAssociation connector
c186 cso30:c:OutputProcess connector
p61_propro_p64
PMID: 17981503,17486092
For example, in chronic inflammatory diseases perpetuated by effector T cells, activated Th1 cells are attracted to the site of inflammation by chemokines that interact with the CXCR3 receptor, including CXCL9, -10, and -11
c189 cso30:c:InputProcess connector
c190 cso30:c:InputProcess connector
c191 cso30:c:OutputProcess connector
p51_propro_p65
PMID: 17981503,11208713
Expression of these chemokines is highly induced by the combination of IFNgamma and TNFalpha
c193 cso30:c:InputAssociation connector
c194 cso30:c:InputAssociation connector
c192 cso30:c:OutputProcess connector
p61_propro_p66
PMID: 17981503,17486092
For example, in chronic inflammatory diseases perpetuated by effector T cells, activated Th1 cells are attracted to the site of inflammation by chemokines that interact with the CXCR3 receptor, including CXCL9, -10, and -11
c195 cso30:c:InputProcess connector
c196 cso30:c:InputProcess connector
c197 cso30:c:OutputProcess connector
p67_propro_p67
PMID: 17981503
PPARgamma then represses expression of the inflammatory-response gene Egr-1.
c199 cso30:c:InputInhibitor connector
c198 cso30:c:OutputProcess connector
p68_propro_p68
PMID: 17981503,16713977
Recently, suppression of the inflammatory response by CO in macrophages has been ascribed to a CO-mediated burst of reactive oxygen species, which induce the expression of PPARgamma
c201 cso30:c:InputAssociation connector
c200 cso30:c:OutputProcess connector
p69_propro_p69
PMID: 17981503,16713977
Recently, suppression of the inflammatory response by CO in macrophages has been ascribed to a CO-mediated burst of reactive oxygen species, which induce the expression of PPARgamma
c202 cso30:c:InputAssociation connector
c203 cso30:c:OutputProcess connector
p70_propro_p70
PMID: 17981503,16943204
Recent studies have demonstrated that PPARdelta binds to ERK5 and is required for ERK5-mediated repression of NF-KappaB
c204 cso30:c:InputProcess connector
c205 cso30:c:InputProcess connector
c206 cso30:c:OutputProcess connector
RXR_enti_MO000017464
RXR
PPAR-alpha_enti_e5
PPAR-alpha
PPAR-alpha:RXR_enti_e6
PPAR-alpha:RXR
PPRE_enti_e11
PPRE
PPAR-alpha:RXR:PPRE_enti_e12
PPAR-alpha:RXR:PPRE
Troglitazone_enti_e13
Troglitazone
PPAR-gamma_enti_e14
PPAR-gamma
PPAR-gamma:Troglitazone_enti_e15
PPAR-gamma:Troglitazone
MCP1_enti_G010815
MCP1
GW0742_enti_e16
GW0742
PPAR-delta_enti_e17
PPAR-delta
LPS_enti_MO000016882
LPS
iNOS_enti_G010514
iNOS
NCoR:HDAC3:TBL1:TBLR1_enti_e18
NCoR:HDAC3:TBL1:TBLR1
iNOS_enti_e19
iNOS
TLR4_enti_MO000019394
TLR4
LPS:TLR4_enti_e20
LPS:TLR4
p50:RelA-p65_enti_MO000016632
p50:RelA-p65
p50:RelA-p65:IkappaB_enti_e21
p50:RelA-p65:IkappaB
p50:RelA-p65:IkappaB{active}_enti_e22
p50:RelA-p65:IkappaB{active}
Degradants_enti_e23
p50:RelA-p65_enti_e24
p50:RelA-p65
19s proteosome_enti_e25
19s proteosome
NCoR:HDAC3:TBL1:TBLR1{ub}_enti_e26
NCoR:HDAC3:TBL1:TBLR1{ub}
proteosome degradants_enti_e27
p50:RelA-p65:iNOS_enti_e28
p50:RelA-p65:iNOS
Activator complex_enti_e29
Activator complex
p50:RelA-p65:iNOS:Activator complex_enti_e30
p50:RelA-p65:iNOS:Activator complex
SUMO-1_enti_MO000019971
SUMO-1
PPAR-gamma:troglitazone:SUMO-1_enti_e31
PPAR-gamma:troglitazone:SUMO-1
Ubc9_enti_MO000019972
Ubc9
PIAS1_enti_MO000017700
PIAS1
NCoR:HDAC3:TBL1:TBLR1:PPAR-gamma:Troglitazone:SUMO-1_enti_e32
NCoR:HDAC3:TBL1:TBLR1:PPAR-gamma:Troglitazone:SUMO-1
PPAR-gamma:RCXR_enti_e33
PPAR-gamma:RCXR
Inflammatory response gene mRNA_enti_e34
Inflammatory response gene mRNA
RelA-p65_enti_MO000000193
RelA-p65
RelA-p65:PPAR-alpha_enti_e35
RelA-p65:PPAR-alpha
BCL-6_enti_MO000034742
BCL-6
PPARdelta:BCL-6_enti_e36
PPARdelta:BCL-6
PPARdelta:GW0742_enti_e37
PPARdelta:GW0742
LXRalpha_enti_e38
LXRalpha
LXRbeta_enti_e39
LXRbeta
Ligand_enti_e40
Ligand
LXRalpha:Ligand_enti_e41
LXRalpha:Ligand
LXRbeta:Ligand_enti_e42
LXRbeta:Ligand
SUMO-2_enti_e43
SUMO-2
SUMO-3_enti_e44
SUMO-3
LXRalpha:ligand:SUMO-2:SUMo-3_enti_e45
LXRalpha:ligand:SUMO-2:SUMo-3
HDAC4_enti_MO000042976
HDAC4
LXRalpha:ligand:SUMO-2:SUMo-3:NCor co-repressor complex_enti_e46
LXRalpha:ligand:SUMO-2:SUMo-3:NCor co-repressor complex
LXRbeta:ligand:SUMO-2:SUMo-3_enti_e47
LXRbeta:ligand:SUMO-2:SUMo-3
LXRbeta:ligand:SUMO-2:SUMo-3:NCor co-repressor complex_enti_e48
LXRbeta:ligand:SUMO-2:SUMo-3:NCor co-repressor complex
glucocorticoids_enti_MO000021732
glucocorticoids
GR ligand_enti_e49
GR ligand
Glucocorticoids:GR ligand_enti_e63
Glucocorticoids:GR ligand
Glucocorticoids:GRligand:RelA-p65_enti_e64
Glucocorticoids:GRligand:RelA-p65
TNF_enti_MO000000204
TNF
IL-8_enti_e65
IL-8
c-Jun_enti_MO000000049
c-Jun
c-Jun:PPAR-alpha_enti_e66
c-Jun:PPAR-alpha
CD1A_enti_G027553
CD1A
CD40_enti_G010691
CD40
CD83_enti_G027461
CD83
CCR7_enti_G011221
CCR7
IL-12_enti_MO000017265
IL-12
CXCL10_enti_G012252
CXCL10
IL-12_enti_e67
IL-12
CXCL10_enti_e68
CXCL10
RANTES_enti_G010522
RANTES
RANTES_enti_MO000019881
RANTES
Fenofibrate_enti_e69
Fenofibrate
PPAR-alpha:Fenofibrate_enti_e70
PPAR-alpha:Fenofibrate
IFN-gamma_enti_G010453
IFN-gamma
Wy14643_enti_e71
Wy14643
PPARalpha:Wy14643_enti_e72
PPARalpha:Wy14643
IL-17_enti_e73
IL-17
ICAM-1_enti_G010431
ICAM-1
ICAM-2_enti_e74
ICAM-2
VCAM-1_enti_G010430
VCAM-1
TNF-alpha_enti_MO000000289
TNF-alpha
IL-17_enti_MO000007327
IL-17
CXCL8_enti_e75
CXCL8
CXCL1_enti_e10
CXCL1
GW7647_enti_e76
GW7647
PPARgamma:GW7845_enti_e77
PPARgamma:GW7845
CXCL9_enti_e78
CXCL9
CCL2_enti_e79
CCL2
CCL4_enti_e80
CCL4
CCL7_enti_e81
CCL7
CCl12_enti_e82
CCl12
CCL17_enti_e83
CCL17
CCL19_enti_e84
CCL19
GW7647_enti_e85
GW7647
PPAR-alpha:GW7647_enti_e86
PPAR-alpha:GW7647
CXCR3_enti_MO000019843
CXCR3
CXCL10:CXCR3_enti_e87
CXCL10:CXCR3
CXCL9_enti_e88
CXCL9
CXCL9:CXCR3_enti_e89
CXCL9:CXCR3
CXCL11_enti_e90
CXCL11
CXCL11_enti_e91
CXCL11
CXCL11:CXCR3_enti_e92
CXCL11:CXCR3
Egr1_enti_G010625
Egr1
ROS_enti_e93
ROS
PPARgamma_enti_e94
PPARgamma
ERK5_enti_MO000004687
ERK5
PPAR-delta:ERK5_enti_e95
PPAR-delta:ERK5