majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:17967718.csml convertedTime:2009.07.01.11:09

Entity

MO000000214:IL-1 MO000016596:IL-1RII MO000016601:sIL-1RII e1: e10: e11:IL-1R e12:IL-1:IL-1R e13:AcP complex e14:ILR-II:AcP complex e15:D6 e16:D6 ligand: D6 receptor e17:D6 ligand e18:MYD88 e19:IL-1:IL-1R:MYD88 e2: e20:IRAK1 e21:IRAK4 e22:IL-1:IL-1R:MYD88:IRAK1:IRAK4 e23:IRAK-M e24:MYD88s e3: e4: e5:sIL-RII:IL-1 e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:IL-1:IL-1RII e60: e61: e62: e7: e8: e9:

Process

p1 p2 p3 p4 p5 p6 p7 p8 p9
983.0, 111.0
26.0, 26.0

IL-1

--

MO000000214

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p2 p3

true true true true

csml-variable:Double

m185

10

false

infinite

0

unit false false false
TRANSPATHMO000000214

--

Go back
919.0, 219.0
26.0, 26.0

IL-1RII

--

MO000016596

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2 p4

true true true true

csml-variable:Double

m1590

10

false

infinite

0

unit false false false

--

Go back
1061.0, 97.0
22.0, 22.0

sIL-1RII

--

MO000016601

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m1595

10

false

infinite

0

unit false false false

--

Go back
250.12607698033156, 134.59354153591914
709.4323791374874, 1030.0958145076304

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
256.9614085571677, 150.3380790805013
687.6572223651093, 967.3403532673711

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
861.5, 147.34622144112473
21.224956063268888, 32.65377855887522

IL-1R

--

e11

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p3

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
795.5, 142.28392896294667
17.936636702477525, 34.716071037053275

IL-1:IL-1R

--

e12

cso30:c:Complex

cso30:i:CC_Cytosol

--

p3

--

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
668.5, 216.81629656817762
22.34832079280603, 31.183703431822366

AcP complex

--

e13

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p4

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
716.0, 143.55882352941182
24.26470588235294, 40.44117647058824

ILR-II:AcP complex

--

e14

cso30:c:Complex

cso30:i:CC_Cytosol

--

p4

--

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
572.5, 145.23374340949033
23.89806678383128, 36.76625659050966

D6

--

e15

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p5

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
491.5, 146.37601403201054
17.889059416794563, 34.623985967989476

D6 ligand: D6 receptor

--

e16

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p5

--

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
558.0, 26.636647212718863
28.967599114509966, 17.863352787281144

D6 ligand

--

e17

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p5

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
675.0, 321.3454417387804
34.30468907224794, 21.154558261219563

MYD88

--

e18

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p6

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
923.5, 382.75518443751145
24.542117819783453, 34.24481556248854

IL-1:IL-1R:MYD88

--

e19

cso30:c:Complex

cso30:i:CC_Cytosol

--

p6 p8 p9

p7

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
250.12607698033156, 134.59354153591914
709.4323791374874, 1030.0958145076304

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
619.0, 438.58
34.559999999999995, 25.92

IRAK1

--

e20

cso30:c:Protein

cso30:i:CC_Cytosol

--

p8 p9

p7

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
644.5, 521.7007446166231
23.001207486415773, 37.29925538337694

IRAK4

--

e21

cso30:c:Protein

cso30:i:CC_Cytosol

--

p8 p9

p7

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
925.0, 693.8235294117646
21.705882352941178, 36.1764705882353

IL-1:IL-1R:MYD88:IRAK1:IRAK4

--

e22

cso30:c:Complex

cso30:i:CC_Cytosol

--

p7

p8 p9

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
752.0, 600.3564078578111
16.74555659494855, 38.643592142188965

IRAK-M

--

e23

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p8

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
514.0, 574.6783054940634
32.14328838800563, 19.821694505936808

MYD88s

--

e24

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p9

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
264.31472456308126, 148.7821891186689
681.0550839719878, 1001.7185193421312

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
290.5637225911684, 173.61232238848083
628.557087915814, 952.0582528025069

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
1059.5, 237.13497750374938
24.389768371938008, 29.865022496250614

sIL-RII:IL-1

--

e5

cso30:c:Complex

cso30:i:CC_Cytosol

--

p1

p3

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
400.29624041082525, 728.6485567328303
385.80274350190166, 349.8807003453004

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
441.9658104724831, 736.9402206844818
225.59043102345845, 339.10408739831985

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
405.32532645274955, 733.3184223431884
375.74457141805345, 340.54096912458385

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
406.0437673158815, 734.0368632063207
374.3076896917892, 339.10408739831985

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
400.29624041082525, 728.6485567328303
385.80274350190166, 349.8807003453004

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
400.29624041082525, 728.6485567328303
385.80274350190166, 349.8807003453004

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
406.0437673158815, 734.0368632063207
374.3076896917892, 339.10408739831985

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
681.9250587585818, 872.3367293592372
24.102835619252946, 21.81940908690269

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
618.7022628029633, 972.9184501977219
68.25188199754312, 61.78591422935495

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
400.29624041082525, 728.6485567328303
385.80274350190166, 349.8807003453004

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
924.0, 283.3646408839779
23.071823204419893, 25.635359116022105

IL-1:IL-1RII

--

e6

cso30:c:Complex

cso30:i:CC_Cytosol

--

p2

p3 p6

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
491.2277762916027, 884.1326488782543
12.217806009120668, 5.882647337724771

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
490.8197891654613, 866.5892024541806
41.81868042947776, 75.27362477305998

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
508.3632355895353, 915.5476575911305
6.527794018259936, 6.52779401825994

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
259.44698367601734, 138.73872852587002
695.7321412192787, 985.8344731668011

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
261.93255879486685, 156.1377543578169
667.4241332560883, 969.0998414878402

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
268.56075911179903, 173.53678018976376
664.3769759826822, 956.3903399011755

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
1062.0, 178.0
19.0, 19.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000214 MO000016601

e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m185*m1595*0.1

nodelay

--

true

0

false

PMID: 17967718 IL-1RII, which lacks a signaling domain, both in membrane-bound or released form, binds IL-1 preventing its interaction with a signaling receptor complex

Go back
987.0, 199.0
17.0, 17.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000214 MO000016596

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m185*m1590*0.1

nodelay

--

true

0

false

PMID: 17967718 IL-1RII, which lacks a signaling domain, both in membrane-bound or released form, binds IL-1 preventing its interaction with a signaling receptor complex

Go back
870.0, 66.0
19.0, 19.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000214 e11 e6 e5

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c9 : 1

m185*m11*0.1

nodelay

--

true

0

false

PMID: 17967718 IL-1RII, which lacks a signaling domain, both in membrane-bound or released form, binds IL-1 preventing its interaction with a signaling receptor complex

Go back
830.0, 222.0
19.0, 19.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e13 MO000016596

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c12 : 1
stoichiometry:c13 : 1
stoichiometry:c14 : 1

m13*m1590*0.1

nodelay

--

true

0

false

PMID: 17967718, 8332913, 7848516, 11377293 In addition, it forms a dominant negative non signaling complex with the accessory protein (AcP)

Go back
518.0, 94.0
19.0, 19.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e15 e17

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c17 : 1
stoichiometry:c16 : 1

m15*m17*0.1

nodelay

--

true

0

false

PMID: 17967718 D6 binds a broad range of ligands that includes most of the inflammatory CC chemokines

Go back
990.0, 322.0
19.0, 19.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e6 e18

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c18 : 1
stoichiometry:c19 : 1
stoichiometry:c20 : 1

m6*m18*0.1

nodelay

--

true

0

false

PMID: 17967718, 15308102, 12538665 A negative regulation of signal transduction is exerted by IRAK-M, one of the members of the IL-1 receptor associated kinase (IRAK) family, which lacks kinase activity and regulates the dissociation of IRAK-1 and IRAK-4 from the adaptor protein MyD88, and by MyD88s a spliced form of MyD88 which prevents IRAK-4 recruitment.

Go back
1043.0, 443.0
17.0, 17.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e19 e20 e21

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c21 : 1
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1

m19*m20*m21*0.1

nodelay

--

true

0

false

PMID: 17967718, 15308102, 12538665 A negative regulation of signal transduction is exerted by IRAK-M, one of the members of the IL-1 receptor associated kinase (IRAK) family, which lacks kinase activity and regulates the dissociation of IRAK-1 and IRAK-4 from the adaptor protein MyD88, and by MyD88s a spliced form of MyD88 which prevents IRAK-4 recruitment.

Go back
1097.0, 609.0
21.0, 21.0

p8

p8

cso30:i:ME_Dissociation

cso30:i:CC_Cytosol

--

e22 e23

e19 e21 e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c29 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1
stoichiometry:c28 : 1

m22*m23*0.1

nodelay

--

true

0

false

PMID: 17967718, 15308102, 12538665 A negative regulation of signal transduction is exerted by IRAK-M, one of the members of the IL-1 receptor associated kinase (IRAK) family, which lacks kinase activity and regulates the dissociation of IRAK-1 and IRAK-4 from the adaptor protein MyD88, and by MyD88s a spliced form of MyD88 which prevents IRAK-4 recruitment.

Go back
1034.0, 702.0
19.0, 19.0

p9

p9

cso30:i:ME_Dissociation

cso30:i:CC_Cytosol

--

e22 e24

e19 e21 e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c30 : 1
stoichiometry:c34 : 1
stoichiometry:c31 : 1
stoichiometry:c32 : 1
stoichiometry:c33 : 1

m22*m24*0.1

nodelay

--

true

0

false

PMID: 17967718, 15308102, 12538665 A negative regulation of signal transduction is exerted by IRAK-M, one of the members of the IL-1 receptor associated kinase (IRAK) family, which lacks kinase activity and regulates the dissociation of IRAK-1 and IRAK-4 from the adaptor protein MyD88, and by MyD88s a spliced form of MyD88 which prevents IRAK-4 recruitment.

Go back
1009.0, 135.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
882.997736944133, 88.87356695957513

c10

c10

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
891.9464699071453, 86.70523845275918

c11

c11

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
691.0, 232.0

c12

c12

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
857.0, 232.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
746.8262546692157, 175.1716000756318

c14

c14

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
541.506083455352, 118.80370958807373

c15

c15

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
511.49018805215496, 113.0

c16

c16

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
538.3743112075098, 45.0

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
947.0, 302.0

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
709.0, 332.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1072.0, 119.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
953.4630710245168, 341.0

c20

c20

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
948.0, 405.0

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
654.0, 452.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
668.0, 455.7288266937595

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
947.2491077284276, 460.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
947.0, 629.7647058823529

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
952.9137774736627, 421.313065098613

c26

c26

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
675.8773424626189, 543.3955198768276

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
661.5350890719349, 460.68745840488873

c28

c28

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
769.0, 620.0

c29

c29

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1072.0, 197.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
947.0, 712.0

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
944.6250794501946, 424.5570469020753

c31

c31

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
675.30802009874, 548.2546646887831

c32

c32

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
660.7397812930657, 467.3099127742499

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
546.0, 589.0

c34

c34

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
996.0, 137.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
945.0, 213.8479626207359

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
949.5280520215392, 216.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
896.3892583745637, 83.0657561341275

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
873.0, 92.9628001084424

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
818.3768447422535, 85.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back