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PMID: 17967718 IL-1RII, which lacks a signaling domain, both in membrane-bound or released form, binds IL-1 preventing its interaction with a signaling receptor complex

PMID: 17967718 IL-1RII, which lacks a signaling domain, both in membrane-bound or released form, binds IL-1 preventing its interaction with a signaling receptor complex

PMID: 17967718 IL-1RII, which lacks a signaling domain, both in membrane-bound or released form, binds IL-1 preventing its interaction with a signaling receptor complex

PMID: 17967718, 8332913, 7848516, 11377293 In addition, it forms a dominant negative non signaling complex with the accessory protein (AcP)

PMID: 17967718 D6 binds a broad range of ligands that includes most of the inflammatory CC chemokines

PMID: 17967718, 15308102, 12538665 A negative regulation of signal transduction is exerted by IRAK-M, one of the members of the IL-1 receptor associated kinase (IRAK) family, which lacks kinase activity and regulates the dissociation of IRAK-1 and IRAK-4 from the adaptor protein MyD88, and by MyD88s a spliced form of MyD88 which prevents IRAK-4 recruitment.

PMID: 17967718, 15308102, 12538665 A negative regulation of signal transduction is exerted by IRAK-M, one of the members of the IL-1 receptor associated kinase (IRAK) family, which lacks kinase activity and regulates the dissociation of IRAK-1 and IRAK-4 from the adaptor protein MyD88, and by MyD88s a spliced form of MyD88 which prevents IRAK-4 recruitment.

indirect

PMID: 17967718, 15308102, 12538665 A negative regulation of signal transduction is exerted by IRAK-M, one of the members of the IL-1 receptor associated kinase (IRAK) family, which lacks kinase activity and regulates the dissociation of IRAK-1 and IRAK-4 from the adaptor protein MyD88, and by MyD88s a spliced form of MyD88 which prevents IRAK-4 recruitment.

indirect

PMID: 17967718, 15308102, 12538665 A negative regulation of signal transduction is exerted by IRAK-M, one of the members of the IL-1 receptor associated kinase (IRAK) family, which lacks kinase activity and regulates the dissociation of IRAK-1 and IRAK-4 from the adaptor protein MyD88, and by MyD88s a spliced form of MyD88 which prevents IRAK-4 recruitment.