Entity
Rho family
--
MO000000020
cso30:c:Protein
cso30:i:CC_CellComponent
--
--
csml-variable:Double
m72
10
infinite
0
TRANSPATH | MO000000020 |
--
Vav-1
--
MO000000044
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m74
10
infinite
0
InterPro | IPR001452 |
TRANSPATH | MO000000044 |
--
PLCgamma
--
MO000000102
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m90
10
infinite
0
TRANSPATH | MO000000102 |
--
Src family
--
MO000000136
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m122
10
infinite
0
TRANSPATH | MO000000136 |
--
Syk
--
MO000008301
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m1066
10
infinite
0
InterPro | IPR000719 |
TRANSPATH | MO000008301 |
--
beta1-integrin
--
MO000017377
cso30:c:Protein
cso30:i:CC_CellComponent
--
--
csml-variable:Double
m2211
10
infinite
0
InterPro | IPR006209 |
TRANSPATH | MO000017377 |
--
beta2-integrin
--
MO000017380
cso30:c:Protein
cso30:i:CC_CellComponent
--
--
csml-variable:Double
m2214
10
infinite
0
InterPro | IPR006209 |
TRANSPATH | MO000017380 |
--
beta3-integrin
--
MO000017383
cso30:c:Complex
cso30:i:CC_CellComponent
--
--
csml-variable:Double
m2217
10
infinite
0
InterPro | IPR006209 |
TRANSPATH | MO000017383 |
--
ZAP-70
--
MO000017772
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m2529
10
infinite
0
InterPro | IPR000719 |
TRANSPATH | MO000017772 |
--
SLP-76
--
MO000017773
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m2530
10
infinite
0
InterPro | IPR002965 |
TRANSPATH | MO000017773 |
--
SLP-65
--
MO000017796
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m2552
10
infinite
0
TRANSPATH | MO000017796 |
--
FcRgamma
--
MO000018210
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m2891
10
infinite
0
TRANSPATH | MO000018210 |
--
Vav family
--
MO000021167
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m5542
10
infinite
0
TRANSPATH | MO000021167 |
--
Vav-3
--
MO000031010
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m10568
10
infinite
0
TRANSPATH | MO000031010 |
--
Syk{pY}
--
MO000035462
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m13959
10
infinite
0
TRANSPATH | MO000035462 |
--
alpha IIb-integrin
--
MO000037486
cso30:c:Protein
cso30:i:CC_CellComponent
--
--
csml-variable:Double
m15748
10
infinite
0
InterPro | IPR000834 |
TRANSPATH | MO000037486 |
--
DAP12
--
MO000066771
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m41628
10
infinite
0
TRANSPATH | MO000066771 |
--
--
e1
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane
--
--
--
csml-variable:Double
m1
0
infinite
0
--
--
e10
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytosol
--
--
--
csml-variable:Double
m10
0
infinite
0
--
alpha IIb-integrin:beta3-integrin
--
e11
cso30:c:Protein
cso30:i:CC_CellComponent
--
--
csml-variable:Double
m11
10
infinite
0
TRANSPATH | MO000037488 |
--
alpha V-integrin:beta3-integrin
--
e12
cso30:c:Protein
cso30:i:CC_CellComponent
--
--
csml-variable:Double
m12
10
infinite
0
TRANSPATH | MO000117932 |
--
beta2 integrin ligand : beta2-integrin
--
e13
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m13
0
infinite
0
--
beta3-integrin ligand : beta3-integrin
--
e14
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m14
0
infinite
0
--
immunoreceptor ligand: immunoreceptor {pY}2
--
e15
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m15
0
infinite
0
--
alpha IIb-integrin:beta3-integrin ligand: alpha IIb-integrin:beta3-integrin
--
e16
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m16
0
infinite
0
--
alpha V-integrin:beta3-integrin ligand
--
e17
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m17
0
infinite
0
--
alpha V-integrin:beta3-integrin ligand: alpha V-integrin:beta3-integrin
--
e18
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m18
0
infinite
0
--
alpha IIb-integrin:beta3-integrin ligand
--
e19
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m19
0
infinite
0
--
--
e2
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m2
0
infinite
0
--
beta1-integrin ligand: beta1-integrin
--
e20
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m20
0
infinite
0
--
beta3 integrin ligand : beta3-integrin {p}: DAP12: FcRgamma
--
e21
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m21
0
infinite
0
--
beta1-integrin ligand
--
e22
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m22
0
infinite
0
--
beta2 integrin ligand
--
e23
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m23
0
infinite
0
--
alpha IIb-integrin ligand: alpha IIb-integrin
--
e24
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m24
0
infinite
0
--
alpha IIb-integrin ligand
--
e25
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m25
0
infinite
0
--
beta3-integrin ligand
--
e26
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m26
0
infinite
0
--
ERK {activated}
--
e27
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m28
10
infinite
0
TRANSPATH | MO000000011 |
--
csml-variable:Double
m29
0
infinite
0
--
immunoreceptor ligand
--
e29
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m30
0
infinite
0
--
--
e3
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
--
csml-variable:Double
m3
0
infinite
0
--
beta2 integrin ligand : beta2-integrin {pY}2: Syk
--
e30
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
csml-variable:Double
m31
0
infinite
0
--
beta3-integrin ligand : beta3-integrin [pY}2
--
e31
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m32
0
infinite
0
--
beta3-integrin ligand : beta3-integrin [pY}2: Syk
--
e32
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
csml-variable:Double
m33
0
infinite
0
--
beta3 integrin ligand : beta3-integrin {p}: DAP12: FcRgamma
--
e33
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m34
0
infinite
0
--
beta3 integrin ligand : beta3-integrin {p}: DAP12 {p}: FcRgamma {p}
--
e34
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m35
0
infinite
0
--
beta2 integrin ligand : beta2-integrin {p}: DAP12 {p}: FcRgamma {p}
--
e35
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m36
0
infinite
0
--
beta3 integrin ligand : beta3-integrin {p}: DAP12 {p}: FcRgamma {p}: Syk
--
e36
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m37
0
infinite
0
--
beta2 integrin ligand : beta2-integrin {p}: DAP12 {p}: FcRgamma {p}: Syk
--
e37
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m38
0
infinite
0
--
beta3 integrin ligand : beta3-integrin {p}: DAP12 {p}: FcRgamma {p}: Syk {p}
--
e38
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m39
0
infinite
0
--
beta2 integrin ligand : beta2-integrin {p}: DAP12 {p}: FcRgamma {p}: Syk {p}
--
e39
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m40
0
infinite
0
--
--
e4
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m4
0
infinite
0
--
beta3 integrin ligand : beta3-integrin {p}: DAP12 {p}: FcRgamma {p}: ZAP-70
--
e40
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m41
0
infinite
0
--
beta2 integrin ligand : beta2-integrin {p}: DAP12 {p}: FcRgamma {p}: ZAP-70
--
e41
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
csml-variable:Double
m42
0
infinite
0
--
beta3 integrin ligand : beta3-integrin {p}: DAP12 {p}: FcRgamma {p}: ZAP-70 [p}
--
e42
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m43
0
infinite
0
--
beta2 integrin ligand : beta2-integrin {p}: DAP12 {p}: FcRgamma {p}: ZAP-70 {p}
--
e43
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m44
0
infinite
0
--
SLP-65 {activated}
--
e44
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m46
10
infinite
0
TRANSPATH | MO000017796 |
--
SLP-76 {activated}
--
e45
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m47
10
infinite
0
InterPro | IPR002965 |
TRANSPATH | MO000017773 |
--
Vav family {activated}
--
e46
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m45
10
infinite
0
TRANSPATH | MO000021167 |
--
Vav-3 {activated}
--
e47
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m49
10
infinite
0
TRANSPATH | MO000031010 |
--
PLCgamma {activated}
--
e48
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m63
10
infinite
0
TRANSPATH | MO000000102 |
--
beta2 integrin ligand : beta2-integrin {pY}2: ZAP-70
--
e49
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m48
0
infinite
0
--
immunoreceptor ligand: immunoreceptor
--
e5
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
csml-variable:Double
m5
0
infinite
0
--
--
e50
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelopeLumen
--
--
--
csml-variable:Double
m50
0
infinite
0
--
--
e51
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearPore
--
--
--
csml-variable:Double
m51
0
infinite
0
--
--
e52
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearInnerMembrane
--
--
--
csml-variable:Double
m52
0
infinite
0
--
--
e53
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearLumen
--
--
--
csml-variable:Double
m53
0
infinite
0
--
--
e54
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearOuterMembrane
--
--
--
csml-variable:Double
m54
0
infinite
0
--
--
e55
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleus
--
--
--
csml-variable:Double
m55
0
infinite
0
--
--
e56
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleoplasm
--
--
--
csml-variable:Double
m56
0
infinite
0
--
--
e57
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearBody
--
--
--
csml-variable:Double
m57
0
infinite
0
--
--
e58
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleolus
--
--
--
csml-variable:Double
m58
0
infinite
0
--
--
e59
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelope
--
--
--
csml-variable:Double
m59
0
infinite
0
--
beta2 integrin ligand : beta2-integrin {pY}2
--
e6
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m6
0
infinite
0
--
--
e60
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Chromatin
--
--
--
csml-variable:Double
m60
0
infinite
0
--
--
e61
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearChromosome
--
--
--
csml-variable:Double
m61
0
infinite
0
--
--
e62
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearCentromere
--
--
--
csml-variable:Double
m62
0
infinite
0
--
beta3-integrin ligand : beta3-integrin [pY}2: ZAP-70
--
e63
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m64
0
infinite
0
--
beta1-integrin ligand: beta1-integrin {p}
--
e64
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m65
0
infinite
0
--
beta1-integrin ligand: beta1-integrin {p}: ZAP-70
--
e65
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m66
0
infinite
0
--
alpha V-integrin:beta3-integrin ligand: beta3-integrin
--
e66
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m67
0
infinite
0
--
alpha V-integrin:beta3-integrin ligand: beta3-integrin: Syk
--
e67
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
csml-variable:Double
m68
0
infinite
0
--
alpha IIb-integrin:beta3-integrin ligand: alpha IIb-integrin:beta3-integrin {p}: Src
--
e68
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m69
0
infinite
0
--
alpha IIb-integrin:beta3-integrin ligand: alpha IIb-integrin:beta3-integrin {p}: Src: Syk
--
e69
cso30:c:Complex
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m70
0
infinite
0
--
--
e7
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell
--
--
--
csml-variable:Double
m7
0
infinite
0
--
alpha IIb-integrin:beta3-integrin ligand: alpha IIb-integrin:beta3-integrin: Src
--
e70
cso30:c:Complex
cso30:i:CC_Extracellular
--
csml-variable:Double
m71
0
infinite
0
--
Rho family {activated}
--
e71
cso30:c:Protein
cso30:i:CC_CellComponent
--
--
csml-variable:Double
m73
10
infinite
0
TRANSPATH | MO000000020 |
--
Vav-1 {activated}
--
e72
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m75
10
infinite
0
InterPro | IPR001452 |
TRANSPATH | MO000000044 |
--
TCR ligand : TCR
--
e73
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m76
0
infinite
0
--
SLP-76 {p}
--
e74
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m77
0
infinite
0
--
--
e8
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell_WithoutCellWall_
--
--
--
csml-variable:Double
m8
0
infinite
0
--
--
e9
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytoplasm
--
--
--
csml-variable:Double
m9
0
infinite
0
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1
m29*m30*0.1
nodelay
--
0
PMID: 17913496 Ligand binding and receptor clustering leads to phosphorylation of these tyrosines by Src-family tyrosine kinases.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c29 : 1
stoichiometry:c28 : 1
m2211*m22*0.1
nodelay
--
0
PMID: 17913496, 7541794, 17086186, 9351824 Similar results were later obtained using beta1 or beta2 integrin-mediated activation of human monocytic cell lines [11] or primary murine macrophages [8] and [12], and beta2 integrin-dependent activation of human neutrophils [13] as well as in CHO cells heterologously expressing the alphaIIb and beta3 integrin subunits and Syk.
p11
p11
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c33 : 1
stoichiometry:c34 : 1
m20*m1066*0.1
nodelay
--
0
PMID: 17913496, 7541794, 17086186, 9351824 Similar results were later obtained using beta1 or beta2 integrin-mediated activation of human monocytic cell lines [11] or primary murine macrophages [8] and [12], and beta2 integrin-dependent activation of human neutrophils [13] as well as in CHO cells heterologously expressing the alphaIIb and beta3 integrin subunits and Syk.
p12
p12
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c86 : 1
stoichiometry:c45 : 1
m37*m122*0.1
nodelay
--
0
PMID: 17913496, 10689303, 10781399 The phospho-ITAM then recruits the Syk or the related ZAP-70 tyrosine kinase through their dual phosphotyrosine-binding SH2 domains, leading to their phosphorylation and activation, which in turn initiates further downstream signaling. PMID: 17913496, 17086186, 10547366, 11940607 Src-family kinases are indeed involved in integrin-mediated responses, including Syk phosphorylation, in neutrophils [8], [20] and [28], macrophages [12] and [29] and platelets.
p13
p13
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c42 : 1
stoichiometry:c43 : 1
m24*m1066*0.1
nodelay
--
0
PMID: 17913496, 7541794, 17086186, 9351824 Similar results were later obtained using beta1 or beta2 integrin-mediated activation of human monocytic cell lines [11] or primary murine macrophages [8] and [12], and beta2 integrin-dependent activation of human neutrophils [13] as well as in CHO cells heterologously expressing the alphaIIb and beta3 integrin subunits and Syk.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c37 : 1
stoichiometry:c38 : 1
m15748*m25*0.1
nodelay
--
0
PMID: 17913496, 7541794, 17086186, 9351824 Similar results were later obtained using beta1 or beta2 integrin-mediated activation of human monocytic cell lines [11] or primary murine macrophages [8] and [12], and beta2 integrin-dependent activation of human neutrophils [13] as well as in CHO cells heterologously expressing the alphaIIb and beta3 integrin subunits and Syk.
p15
p15
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c87 : 1
stoichiometry:c75 : 1
m38*m122*0.1
nodelay
--
0
PMID: 17913496, 10689303, 10781399 The phospho-ITAM then recruits the Syk or the related ZAP-70 tyrosine kinase through their dual phosphotyrosine-binding SH2 domains, leading to their phosphorylation and activation, which in turn initiates further downstream signaling. PMID: 17913496, 17086186, 10547366, 11940607 Src-family kinases are indeed involved in integrin-mediated responses, including Syk phosphorylation, in neutrophils [8], [20] and [28], macrophages [12] and [29] and platelets.
p16
p16
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c89 : 1
stoichiometry:c48 : 1
m27*m39*0.1
nodelay
--
0
PMID: 17913496, 17086186, 11672534 These studies revealed that Syk is required for beta2 integrin-mediated spreading and extracellular signal-regulated protein kinase (ERK) activation in macrophages [8] and [19] , various integrin-mediated functional and signaling responses of neutrophils [20], as well as alphaIIb/beta3 integrin-mediated spreading and concomitant downstream signaling in platelets. PMID: 17913496, 17086186 The two ITAM-bearing adapters are also required for beta2 integrin-induced activation of ERK in macrophages with a predominant role for DAP12 in these cells.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c53 : 1
stoichiometry:c54 : 1
m6*m1066*0.1
nodelay
--
0
PMID: 17913496 Later studies suggested that this ITAM-independent Syk activation occurs through the direct binding of Syk to integrin beta-chains.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c51 : 1
stoichiometry:c50 : 1
m13*m122*0.1
nodelay
--
0
PMID: 17913496, 16943434, 17086186, 17353363 Unexpectedly, three recent reports using genetically modified mice indicate that beta2 and beta3 integrins, which do not share structural similarity with classical immunoreceptors, also signal by an ITAM-based, immunoreceptor-like mechanism in several different primary cell types. PMID: 17913496, 16943434, 17086186 The ITAM-mediated signaling model proposes that integrins activate Syk through Src-family mediated phosphorylation of the ITAM tyrosines within transmembrane adapters (DAP12 and FcR¦Ã) possibly through association with yet unidentified immunoreceptor-like molecules, followed by recruitment of Syk via its tandem SH2 domains [7] and 8[8] PY, phosphotyrosine.
p19
p19
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c57 : 1
stoichiometry:c56 : 1
m14*m122*0.1
nodelay
--
0
PMID: 17913496, 16943434, 17086186, 17353363 Unexpectedly, three recent reports using genetically modified mice indicate that beta2 and beta3 integrins, which do not share structural similarity with classical immunoreceptors, also signal by an ITAM-based, immunoreceptor-like mechanism in several different primary cell types. PMID: 17913496, 16943434, 17086186 The ITAM-mediated signaling model proposes that integrins activate Syk through Src-family mediated phosphorylation of the ITAM tyrosines within transmembrane adapters (DAP12 and FcR¦Ã) possibly through association with yet unidentified immunoreceptor-like molecules, followed by recruitment of Syk via its tandem SH2 domains [7] and 8[8] PY, phosphotyrosine.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c5 : 1
stoichiometry:c30 : 1
stoichiometry:c6 : 1
m2214*m23*0.1
nodelay
--
0
PMID: 17913496, 7541794, 17086186, 9351824 Similar results were later obtained using beta1 or beta2 integrin-mediated activation of human monocytic cell lines [11] or primary murine macrophages [8] and [12], and beta2 integrin-dependent activation of human neutrophils [13] as well as in CHO cells heterologously expressing the alphaIIb and beta3 integrin subunits and Syk. PMID: 17913496, 16943434, 17086186, 17353363 Unexpectedly, three recent reports using genetically modified mice indicate that beta2 and beta3 integrins, which do not share structural similarity with classical immunoreceptors, also signal by an ITAM-based, immunoreceptor-like mechanism in several different primary cell types.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c59 : 1
stoichiometry:c60 : 1
m32*m1066*0.1
nodelay
--
0
PMID: 17913496 Later studies suggested that this ITAM-independent Syk activation occurs through the direct binding of Syk to integrin beta-chains.
p21
p21
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c61 : 1
stoichiometry:c62 : 1
stoichiometry:c67 : 1
m6*m41628*m2891*0.1
nodelay
--
0
PMID: 17913496, 17086186 Integrin-mediated adhesion of neutrophils leads to phosphorylation of DAP12 and FcRgamma by Src-family kinases and their association with the Syk SH2 domains [8]. DAP12 and/or FcRgamma are also required for adhesion-induced Syk phosphorylation in neutrophils and macrophages. PMID: 17913496 DAP12, FcRgamma and all known DAP12- and FcRgamma-associated molecules contain a charged residue within their membrane-spanning region (Box 2). These residues probably form intramembrane salt bridges that stabilize the receptor?adapter complex.
p22
p22
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c63 : 1
stoichiometry:c36 : 1
stoichiometry:c66 : 1
m21*m122*0.1
nodelay
--
0
PMID: 17913496, 17086186 Integrin-mediated adhesion of neutrophils leads to phosphorylation of DAP12 and FcRgamma by Src-family kinases and their association with the Syk SH2 domains [8]. DAP12 and/or FcRgamma are also required for adhesion-induced Syk phosphorylation in neutrophils and macrophages.
p23
p23
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1
stoichiometry:c41 : 1
stoichiometry:c69 : 1
m34*m122*0.1
nodelay
--
0
PMID: 17913496, 17086186 Integrin-mediated adhesion of neutrophils leads to phosphorylation of DAP12 and FcRgamma by Src-family kinases and their association with the Syk SH2 domains [8]. DAP12 and/or FcRgamma are also required for adhesion-induced Syk phosphorylation in neutrophils and macrophages.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1
stoichiometry:c32 : 1
stoichiometry:c71 : 1
m35*m1066*0.1
nodelay
--
0
PMID: 17913496, 17086186 Integrin-mediated adhesion of neutrophils leads to phosphorylation of DAP12 and FcRgamma by Src-family kinases and their association with the Syk SH2 domains [8]. DAP12 and/or FcRgamma are also required for adhesion-induced Syk phosphorylation in neutrophils and macrophages.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c35 : 1
stoichiometry:c73 : 1
m36*m1066*0.1
nodelay
--
0
PMID: 17913496, 17086186 Integrin-mediated adhesion of neutrophils leads to phosphorylation of DAP12 and FcRgamma by Src-family kinases and their association with the Syk SH2 domains [8]. DAP12 and/or FcRgamma are also required for adhesion-induced Syk phosphorylation in neutrophils and macrophages.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c78 : 1
stoichiometry:c80 : 1
m35*m2529*0.1
nodelay
--
0
PMID: 17913496, 10689303, 10781399 The phospho-ITAM then recruits the Syk or the related ZAP-70 tyrosine kinase through their dual phosphotyrosine-binding SH2 domains, leading to their phosphorylation and activation, which in turn initiates further downstream signaling.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c79 : 1
stoichiometry:c81 : 1
m36*m2529*0.1
nodelay
--
0
PMID: 17913496, 10689303, 10781399 The phospho-ITAM then recruits the Syk or the related ZAP-70 tyrosine kinase through their dual phosphotyrosine-binding SH2 domains, leading to their phosphorylation and activation, which in turn initiates further downstream signaling.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c83 : 1
m41*0.1
nodelay
--
0
PMID: 17913496, 10689303, 10781399 The phospho-ITAM then recruits the Syk or the related ZAP-70 tyrosine kinase through their dual phosphotyrosine-binding SH2 domains, leading to their phosphorylation and activation, which in turn initiates further downstream signaling.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c85 : 1
m42*0.1
nodelay
--
0
PMID: 17913496, 10689303, 10781399 The phospho-ITAM then recruits the Syk or the related ZAP-70 tyrosine kinase through their dual phosphotyrosine-binding SH2 domains, leading to their phosphorylation and activation, which in turn initiates further downstream signaling.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c8 : 1
stoichiometry:c39 : 1
stoichiometry:c9 : 1
m2217*m26*0.1
nodelay
--
0
PMID: 17913496, 7541794, 17086186, 9351824 Similar results were later obtained using beta1 or beta2 integrin-mediated activation of human monocytic cell lines [11] or primary murine macrophages [8] and [12], and beta2 integrin-dependent activation of human neutrophils [13] as well as in CHO cells heterologously expressing the alphaIIb and beta3 integrin subunits and Syk. PMID: 17913496, 16943434, 17086186, 17353363 Unexpectedly, three recent reports using genetically modified mice indicate that beta2 and beta3 integrins, which do not share structural similarity with classical immunoreceptors, also signal by an ITAM-based, immunoreceptor-like mechanism in several different primary cell types.
p30
p30
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c90 : 1
stoichiometry:c88 : 1
m27*m40*0.1
nodelay
--
0
PMID: 17913496, 17086186, 11672534 These studies revealed that Syk is required for beta2 integrin-mediated spreading and extracellular signal-regulated protein kinase (ERK) activation in macrophages [8] and [19] , various integrin-mediated functional and signaling responses of neutrophils [20], as well as alphaIIb/beta3 integrin-mediated spreading and concomitant downstream signaling in platelets. PMID: 17913496, 17086186 The two ITAM-bearing adapters are also required for beta2 integrin-induced activation of ERK in macrophages with a predominant role for DAP12 in these cells.
p31
p31
cso30:i:CE_CellDifferentiation
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c91 : 1
stoichiometry:c92 : 1
stoichiometry:c93 : 1
m18*m41628*m2891*0.1
nodelay
--
0
PMID: 17913496 Hence, DAP12 and FcRgamma are required for osteoclast development and function, possibly as a result of their role in alphaV/beta3 integrin signal transduction.
p32
p32
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c94 : 1
stoichiometry:c122 : 1
stoichiometry:c95 : 1
m2552*m43*0.1
nodelay
--
0
PMID: 17913496 Activation of these kinases leads to downstream signaling, such as phosphorylation of SLP-76/SLP-65, Vav family members and PLCgamma isoforms.
p33
p33
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c96 : 1
stoichiometry:c124 : 1
stoichiometry:c97 : 1
m2530*m39*0.1
nodelay
--
0
PMID: 17913496 Activation of these kinases leads to downstream signaling, such as phosphorylation of SLP-76/SLP-65, Vav family members and PLCgamma isoforms.
p34
p34
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c128 : 1
stoichiometry:c98 : 1
stoichiometry:c99 : 1
m39*m5542*0.1
nodelay
--
0
PMID: 17913496 Activation of these kinases leads to downstream signaling, such as phosphorylation of SLP-76/SLP-65, Vav family members and PLCgamma isoforms.
p35
p35
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c100 : 1
stoichiometry:c173 : 1
stoichiometry:c101 : 1
m10568*m44*0.1
nodelay
--
0
PMID: 17913496, 15249579 Later studies, however, revealed that Vav1 and Vav3 have a critical but overlapping role in neutrophil activation by beta2-integrins.
p36
p36
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c102 : 1
stoichiometry:c132 : 1
stoichiometry:c103 : 1
m90*m39*0.1
nodelay
--
0
PMID: 17913496 Activation of these kinases leads to downstream signaling, such as phosphorylation of SLP-76/SLP-65, Vav family members and PLCgamma isoforms.
p37
p37
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c121 : 1
stoichiometry:c107 : 1
m2552*m40*0.1
nodelay
--
0
PMID: 17913496 Activation of these kinases leads to downstream signaling, such as phosphorylation of SLP-76/SLP-65, Vav family members and PLCgamma isoforms.
p38
p38
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c104 : 1
stoichiometry:c120 : 1
stoichiometry:c105 : 1
m2552*m39*0.1
nodelay
--
0
PMID: 17913496 Activation of these kinases leads to downstream signaling, such as phosphorylation of SLP-76/SLP-65, Vav family members and PLCgamma isoforms.
p39
p39
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c109 : 1
stoichiometry:c125 : 1
stoichiometry:c110 : 1
m2530*m40*0.1
nodelay
--
0
PMID: 17913496 Activation of these kinases leads to downstream signaling, such as phosphorylation of SLP-76/SLP-65, Vav family members and PLCgamma isoforms.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c12 : 1
stoichiometry:c10 : 1
stoichiometry:c11 : 1
m122*m5*0.1
nodelay
--
0
PMID: 17913496 Ligand binding and receptor clustering leads to phosphorylation of these tyrosines by Src-family tyrosine kinases.
p40
p40
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c111 : 1
stoichiometry:c126 : 1
stoichiometry:c112 : 1
m2530*m43*0.1
nodelay
--
0
PMID: 17913496 Activation of these kinases leads to downstream signaling, such as phosphorylation of SLP-76/SLP-65, Vav family members and PLCgamma isoforms.
p41
p41
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c129 : 1
stoichiometry:c108 : 1
stoichiometry:c113 : 1
m40*m5542*0.1
nodelay
--
0
PMID: 17913496 Activation of these kinases leads to downstream signaling, such as phosphorylation of SLP-76/SLP-65, Vav family members and PLCgamma isoforms.
p42
p42
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c130 : 1
stoichiometry:c114 : 1
stoichiometry:c115 : 1
m43*m5542*0.1
nodelay
--
0
PMID: 17913496 Activation of these kinases leads to downstream signaling, such as phosphorylation of SLP-76/SLP-65, Vav family members and PLCgamma isoforms.
p43
p43
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c116 : 1
stoichiometry:c133 : 1
stoichiometry:c117 : 1
m90*m40*0.1
nodelay
--
0
PMID: 17913496 Activation of these kinases leads to downstream signaling, such as phosphorylation of SLP-76/SLP-65, Vav family members and PLCgamma isoforms.
p44
p44
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c118 : 1
stoichiometry:c134 : 1
stoichiometry:c119 : 1
m90*m43*0.1
nodelay
--
0
PMID: 17913496 Activation of these kinases leads to downstream signaling, such as phosphorylation of SLP-76/SLP-65, Vav family members and PLCgamma isoforms.
p45
p45
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c123 : 1
stoichiometry:c136 : 1
stoichiometry:c137 : 1
m44*m2552*0.1
nodelay
--
0
PMID: 17913496 Activation of these kinases leads to downstream signaling, such as phosphorylation of SLP-76/SLP-65, Vav family members and PLCgamma isoforms.
p46
p46
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c127 : 1
stoichiometry:c138 : 1
stoichiometry:c139 : 1
m44*m2530*0.1
nodelay
--
0
PMID: 17913496 Activation of these kinases leads to downstream signaling, such as phosphorylation of SLP-76/SLP-65, Vav family members and PLCgamma isoforms.
p47
p47
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c131 : 1
stoichiometry:c140 : 1
stoichiometry:c141 : 1
m44*m5542*0.1
nodelay
--
0
PMID: 17913496 Activation of these kinases leads to downstream signaling, such as phosphorylation of SLP-76/SLP-65, Vav family members and PLCgamma isoforms.
p48
p48
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c135 : 1
stoichiometry:c142 : 1
stoichiometry:c143 : 1
m44*m90*0.1
nodelay
--
0
PMID: 17913496 Activation of these kinases leads to downstream signaling, such as phosphorylation of SLP-76/SLP-65, Vav family members and PLCgamma isoforms.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c144 : 1
stoichiometry:c149 : 1
stoichiometry:c145 : 1
m6*m2529*0.1
nodelay
--
0
PMID: 17913496, 11719224 The beta1 and beta2 integrin chains and the Syk-related ZAP-70 can also participate in such complexes.
p5
p5
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c25 : 1
stoichiometry:c23 : 1
m1066*m18*0.1
nodelay
--
0
PMID: 17013496, 17353363, 14624447, 15073337 Plating preosteoclasts on alphaVbeta3-integrin-ligands also leads to Syk phosphorylation.
p50
p50
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c153 : 1
stoichiometry:c155 : 1
stoichiometry:c154 : 1
m20*m122*0.1
nodelay
--
0
PMID: 17913496, 11719224 The beta1 and beta2 integrin chains and the Syk-related ZAP-70 can also participate in such complexes.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c146 : 1
stoichiometry:c148 : 1
stoichiometry:c147 : 1
m32*m2529*0.1
nodelay
--
0
PMID: 17913496, 11719224 The beta1 and beta2 integrin chains and the Syk-related ZAP-70 can also participate in such complexes.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c150 : 1
stoichiometry:c152 : 1
stoichiometry:c151 : 1
m2529*m65*0.1
nodelay
--
0
PMID: 17913496, 11719224 The beta1 and beta2 integrin chains and the Syk-related ZAP-70 can also participate in such complexes.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c156 : 1
stoichiometry:c157 : 1
stoichiometry:c158 : 1
m67*m1066*0.1
nodelay
--
0
PMID: 17913496, 17353363 Beta3 integrins and Syk can also be co-precipitated from primary murine preosteoclasts following adhesion to alphaV/beta3 integrin-ligands.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c165 : 1
stoichiometry:c160 : 1
m71*0.1
nodelay
--
0
PMID: 17913496, 17353363 However, in contrast to the case of alphaIIb/beta3, this association does not depend on the last amino acids of the beta3 integrin tail.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c161 : 1
stoichiometry:c163 : 1
stoichiometry:c162 : 1
m69*m1066*0.1
nodelay
--
0
PMID: 17913496, 17353363 However, in contrast to the case of alphaIIb/beta3, this association does not depend on the last amino acids of the beta3 integrin tail.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c159 : 1
stoichiometry:c166 : 1
stoichiometry:c164 : 1
m16*m122*0.1
nodelay
--
0
PMID: 17913496, 17353363, 14593208, 15937333 The interpretation of these findings is further complicated by the binding of c-Src to the same amino acids in the beta3 cytoplasmic tail.
p57
p57
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c167 : 1
stoichiometry:c169 : 1
stoichiometry:c168 : 1
m72*m45*0.1
nodelay
--
0
PMID: 17913496, 12094222 Members of the Vav family are guanine-nucleotide exchange factors that activate Rho-family small GTPases.
p58
p58
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c170 : 1
stoichiometry:c172 : 1
stoichiometry:c171 : 1
m74*m44*0.1
nodelay
--
0
PMID: 17913496, 15249579 Later studies, however, revealed that Vav1 and Vav3 have a critical but overlapping role in neutrophil activation by beta2-integrins.
p59
p59
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c174 : 1
stoichiometry:c178 : 1
stoichiometry:c175 : 1
m74*m40*0.1
nodelay
--
0
PMID: 17913496, 15249579 Later studies, however, revealed that Vav1 and Vav3 have a critical but overlapping role in neutrophil activation by beta2-integrins.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1
m11*m19*0.1
nodelay
--
0
PMID: 17913496, 7961845 Syk, a central component of immunoreceptor signaling, was shown in 1994 to be activated through alphaIIb/beta3 integrins in human platelets.
p60
p60
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c176 : 1
stoichiometry:c179 : 1
stoichiometry:c177 : 1
m10568*m40*0.1
nodelay
--
0
PMID: 17913496, 15249579 Later studies, however, revealed that Vav1 and Vav3 have a critical but overlapping role in neutrophil activation by beta2-integrins.
PMID: 17913496 Vav1¡Ý/¡Ý animals show a severe defect in B- and T-cell development and an impaired Fcvar epsilonRI-induced activation of mast cells.
p62
p62
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c181 : 1
stoichiometry:c183 : 1
stoichiometry:c182 : 1
m2530*m76*0.1
nodelay
--
0
PMID: 17913491, 16493428 The SLP-76 adapter protein is phosphorylated upon T-cell receptor (TCR) ligation and participates in TCR signaling and T-cell development.
PMID: 17913491, 16493428 The SLP-76 adapter protein is phosphorylated upon T-cell receptor (TCR) ligation and participates in TCR signaling and T-cell development.
PMID: 17913496, 16493428 The SLP-76-related SLP-65 adapter is required for B-cell development and B-cell receptor (BCR)-mediated signal transduction.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1
m12*m17*0.1
nodelay
--
0
PMID: 17013496, 17353363, 14624447, 15073337 Plating preosteoclasts on alphaVbeta3-integrin-ligands also leads to Syk phosphorylation.
p8
p8
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c21 : 1
stoichiometry:c64 : 1
stoichiometry:c20 : 1
stoichiometry:c65 : 1
m41628*m32*m2891*0.1
nodelay
--
0
PMID: 17913496, 17086186 Integrin-mediated adhesion of neutrophils leads to phosphorylation of DAP12 and FcRgamma by Src-family kinases and their association with the Syk SH2 domains [8]. DAP12 and/or FcRgamma are also required for adhesion-induced Syk phosphorylation in neutrophils and macrophages. PMID: 17913496 DAP12, FcRgamma and all known DAP12- and FcRgamma-associated molecules contain a charged residue within their membrane-spanning region (Box 2). These residues probably form intramembrane salt bridges that stabilize the receptor?adapter complex.
p9
p9
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c24 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1
m16*m1066*0.1
nodelay
--
0
PMID: 17913496, 7961845 Syk, a central component of immunoreceptor signaling, was shown in 1994 to be activated through alphaIIb/beta3 integrins in human platelets.
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--