majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:17888644.csml convertedTime:2009.07.01.11:07

Entity

G011341:IL17 MO000007327:IL-17 MO000007384:IL-6 MO000016808:TGFbeta MO000017777:TCR MO000018458:IL-6R MO000019395:TLRs e1: e10: e11:poly I:C e12:CpG DNA: TLR e13:poly I: C: TLR e14:TCR liagnd: TCR e15:TGFbeta-receptor e16:e16 e17:e17 e2: e3: e4: e5:CpG DNA e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:TCR ligand e60: e61: e62: e7: e8: e9:

Process

p1 p2 p3 p4 p5 p6 p7 p8
550.0, 644.0
40.0, 40.0

IL17

--

G011341

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p8

true true true true

csml-variable:Double

m94226

10

false

infinite

0

unit false false false
TRANSFACG011341

--

Go back
546.0, 484.0
40.0, 40.0

IL-17

--

MO000007327

cso30:c:Protein

cso30:i:CC_CellComponent

--

p8

--

true true true true

csml-variable:Double

m840

10

false

infinite

0

unit false false false
TRANSPATHMO000007327

--

Go back
61.0, 615.0
41.5, 41.5

IL-6

--

MO000007384

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7

true true true true

csml-variable:Double

m871

10

false

infinite

0

unit false false false
InterProIPR003573
TRANSPATHMO000007384

--

Go back
66.0, 496.0
32.0, 32.0

TGFbeta

--

MO000016808

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6

true true true true

csml-variable:Double

m1746

10

false

infinite

0

unit false false false
TRANSPATHMO000016808

--

Go back
528.0, 150.0
44.0, 44.0

TCR

--

MO000017777

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m2534

10

false

infinite

0

unit false false false
TRANSPATHMO000017777

--

Go back
143.0, 621.0
38.0, 38.0

IL-6R

--

MO000018458

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7

true true true true

csml-variable:Double

m3096

10

false

infinite

0

unit false false false
InterProIPR003961
TRANSPATHMO000018458

--

Go back
286.0, 152.0
34.0, 34.0

TLRs

--

MO000019395

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p2

true true true true

csml-variable:Double

m3962

10

false

infinite

0

unit false false false
TRANSPATHMO000019395

--

Go back
130.75, 139.9969080091176
856.2594311764528, 1243.2886940682085

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
139.0, 159.0
829.9775981223105, 1167.545103664102

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
336.0, 27.0
60.0, 34.0

poly I:C

--

e11

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p2

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
222.5, 138.0
31.0, 60.0

CpG DNA: TLR

--

e12

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p1

p3 p8

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
350.5, 138.0
31.0, 60.0

poly I: C: TLR

--

e13

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p2

p4

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
447.5, 145.0
37.14397600399933, 45.482419596733884

TCR liagnd: TCR

--

e14

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p5

p3 p4

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
146.0, 488.0
40.0, 40.0

TGFbeta-receptor

--

e15

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6

true true true true

csml-variable:Double

m15

10

false

infinite

0

unit false false false
TRANSPATHMO000061699

--

Go back
146.5, 561.0
31.640559906682213, 38.74354274287619

e16

--

e16

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p6

p8

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
146.5, 684.0
31.91001499750042, 39.07348775204133

e17

--

e17

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p7

p8

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
130.75, 139.9969080091176
856.2594311764528, 1243.2886940682085

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
147.87518862352903, 157.12209663264667
822.0090539293948, 1209.0383168211513

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
179.55678757705792, 187.09117672382234
758.6458560223374, 1149.1001566387988

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
208.0, 29.5
60.0, 21.0

CpG DNA

--

e5

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p1

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
317.0, 593.0
465.6500709748862, 422.29345356567933

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
367.29367619468036, 603.0077409313898
272.27955732982184, 409.2864683429171

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
323.06992643728904, 598.6363602631969
453.51021810030846, 411.0207330392853

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
323.93705878547314, 599.503492611381
451.7759534039399, 409.2864683429171

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
317.0, 593.0
465.6500709748862, 422.29345356567933

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
317.0, 593.0
465.6500709748862, 422.29345356567933

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
323.93705878547314, 599.503492611381
451.7759534039399, 409.2864683429171

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
656.9158804881849, 766.4264696368291
29.091257918298922, 26.33524401024959

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
580.6082338479803, 887.8249983826097
82.37757307749382, 74.57338194383664

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
317.0, 593.0
465.6500709748862, 422.29345356567933

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
444.0, 21.5
44.88576449912126, 29.175746924428825

TCR ligand

--

e6

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p5

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
426.7511016961721, 780.6637213250547
14.746453546866459, 7.100144300343119

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
426.25867587120234, 759.4894108513561
50.4736470593979, 90.85256470691624

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
447.43298634490145, 818.5805098477247
7.878813199515761, 7.8788131995157675

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
142.0, 145.0
839.7237354966342, 1189.8668429177399

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
145.0, 166.0
805.5569854171277, 1169.6687428256696

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
153.0, 187.0
801.8791759029863, 1154.3288303559784

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
223.0, 81.0
30.0, 30.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e5 MO000019395

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c5 : 1
stoichiometry:c2 : 1

m5*m3962*0.1

nodelay

--

true

0

false

PMID: 17888644, 17339441, 15128790, 16761317 In the presence of TCR stimulation, TLR ligands including CpG and PolyI:C enhance proliferation and survival of T cells whilst lowering the threshold required for antigen-induced T cell activation.

Go back
351.0, 85.0
30.0, 30.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e11 MO000019395

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c3 : 1
stoichiometry:c6 : 1
stoichiometry:c4 : 1

m11*m3962*0.1

nodelay

--

true

0

false

PMID: 17888644, 17339441, 15128790, 16761317 In the presence of TCR stimulation, TLR ligands including CpG and PolyI:C enhance proliferation and survival of T cells whilst lowering the threshold required for antigen-induced T cell activation.

Go back
63.0, 213.0
30.0, 30.0

p3

p3

cso30:i:CE_CellProliferation

cso30:i:CC_Extracellular

--

e12 e14

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c12 : 1

m12*m14*0.1

nodelay

--

true

0

false

PMID: 17888644, 17339441, 15128790, 16761317 In the presence of TCR stimulation, TLR ligands including CpG and PolyI:C enhance proliferation and survival of T cells whilst lowering the threshold required for antigen-induced T cell activation.

Go back
67.0, 265.0
30.0, 30.0

p4

p4

cso30:i:CE_CellProliferation

cso30:i:CC_Extracellular

--

e13 e14

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c8 : 1
stoichiometry:c13 : 1

m13*m14*0.1

nodelay

--

true

0

false

PMID: 17888644, 17339441, 15128790, 16761317 In the presence of TCR stimulation, TLR ligands including CpG and PolyI:C enhance proliferation and survival of T cells whilst lowering the threshold required for antigen-induced T cell activation.

Go back
451.0, 77.0
30.0, 30.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e6 MO000017777

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c9 : 1
stoichiometry:c10 : 1
stoichiometry:c11 : 1

m6*m2534*0.1

nodelay

--

true

0

false

PMID: 17888644, 17339441, 15128790, 16761317 In the presence of TCR stimulation, TLR ligands including CpG and PolyI:C enhance proliferation and survival of T cells whilst lowering the threshold required for antigen-induced T cell activation.

Go back
67.0, 565.0
30.0, 30.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016808 e15

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c14 : 1
stoichiometry:c15 : 1
stoichiometry:c16 : 1

m1746*m15*0.1

nodelay

--

true

0

false

PMID: 17888644 Indeed, production of IL-17 required simultaneous exposure to CpG and the polarizing cytokines IL-6 and TGF-beta.

Go back
67.0, 689.0
30.0, 30.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000007384 MO000018458

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1

m871*m3096*0.1

nodelay

--

true

0

false

PMID: 17888644 Indeed, production of IL-17 required simultaneous exposure to CpG and the polarizing cytokines IL-6 and TGF-beta.

Go back
475.0, 541.0
30.0, 30.0

p8

p8

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G011341 e16 e17 e12

MO000007327

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c17 : 1
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1
stoichiometry:c18 : 1

m94226*m16*m17*m12*0.1

nodelay

--

true

0

false

PMID: 17888644 Indeed, production of IL-17 required simultaneous exposure to CpG and the polarizing cytokines IL-6 and TGF-beta.

Go back
238.0, 51.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
486.77846408158626, 111.5325719930081

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
466.0, 107.0

c11

c11

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
100.90568189827019, 171.0

c12

c12

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
104.67631553499534, 173.0

c13

c13

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
82.0, 528.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
103.07405281892237, 525.0

c15

c15

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
97.0, 580.0

c16

c16

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
505.757605382452, 577.4315776466481

c17

c17

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
505.0, 522.5116931692603

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
82.0, 657.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
238.0, 111.0

c2

c2

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
103.23370760249931, 655.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
97.0, 704.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
178.0, 557.5909734841225

c22

c22

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
178.0, 566.290062160352

c23

c23

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
254.0, 192.0

c24

c24

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
366.0, 61.0

c3

c3

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
366.0, 115.0

c4

c4

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
256.3597161657171, 116.93914494038921

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
318.0, 120.89062016604313

c6

c6

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
100.50477179311511, 174.0

c7

c7

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
104.44387268422457, 174.0

c8

c8

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
466.0, 51.0

c9

c9

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back