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PMID: 17681884,16902195,17038530
Synthetic CpG oligodeoxydinucleotide, a TLR9 ligand, can affect mesenchymal stem-cell proliferation and
Pam3Cys, a prototypic TLR2 ligand, inhibits adipogenic
differentiation of mesenchymal stem cells
PMID: 17681884,16902195,17038530
Synthetic CpG oligodeoxydinucleotide, a TLR9 ligand, can affect mesenchymal stem-cell proliferation and
Pam3Cys, a prototypic TLR2 ligand, inhibits adipogenic
differentiation of mesenchymal stem cells
indirect
PMID: 17681884,17525261
Interestingly,
leptin is capable of inducing TLR expression and
responsiveness in preadipocytes and mature adipocytes, indicating that this adipokine immunomodulates adipocyte
function. In this context, mature adipocytes seem to
be responsive to a broader spectrum of TLR ligands than
preadipocytes
indirect
PMID: 17681884
Preadipocytes can react rapidly (within 4 h) to the TLR4
ligand lipopolysaccharide (LPS) by secreting proinflammatory
mediators, such as IL-6 and the chemokines CCL2,
CCL5 and CCL11
PMID: 17681884
Preadipocytes can react rapidly (within 4 h) to the TLR4
ligand lipopolysaccharide (LPS) by secreting proinflammatory
mediators, such as IL-6 and the chemokines CCL2,
CCL5 and CCL11
PMID: 17681884,16873530,17090751
The
proinflammatory response capacity of adipose tissue to
LPS, such as the induction of IL-6, TNF, IL-1b, IL-8 and
CCL2 secretion, seems to be based mainly on preadipocytes
rather than on mature adipocytes
indirect
PMID: 17681884
Preadipocytes can react rapidly (within 4 h) to the TLR4
ligand lipopolysaccharide (LPS) by secreting proinflammatory
mediators, such as IL-6 and the chemokines CCL2,
CCL5 and CCL11
PMID: 17681884,16873530,17090751
The
proinflammatory response capacity of adipose tissue to
LPS, such as the induction of IL-6, TNF, IL-1b, IL-8 and
CCL2 secretion, seems to be based mainly on preadipocytes
rather than on mature adipocytes
indirect
indirect
PMID: 17681884
Preadipocytes can react rapidly (within 4 h) to the TLR4
ligand lipopolysaccharide (LPS) by secreting proinflammatory
mediators, such as IL-6 and the chemokines CCL2,
CCL5 and CCL11
indirect
indirect
PMID: 17681884
Preadipocytes can react rapidly (within 4 h) to the TLR4
ligand lipopolysaccharide (LPS) by secreting proinflammatory
mediators, such as IL-6 and the chemokines CCL2,
CCL5 and CCL11
indirect
indirect
PMID: 17681884,16873530,17090751
The
proinflammatory response capacity of adipose tissue to
LPS, such as the induction of IL-6, TNF, IL-1b, IL-8 and
CCL2 secretion, seems to be based mainly on preadipocytes
rather than on mature adipocytes
indirect
indirect
PMID: 17681884,16873530,17090751
The
proinflammatory response capacity of adipose tissue to
LPS, such as the induction of IL-6, TNF, IL-1b, IL-8 and
CCL2 secretion, seems to be based mainly on preadipocytes
rather than on mature adipocytes
PMID: 17681884,16873530,17090751
The
proinflammatory response capacity of adipose tissue to
LPS, such as the induction of IL-6, TNF, IL-1b, IL-8 and
CCL2 secretion, seems to be based mainly on preadipocytes
rather than on mature adipocytes
indirect
indirect
PMID: 17681884,17090751,10823826
Stimulation with bacterial LPS, yeast cell wall zymosan or
TNF of murine and human adipocytes leads to a dramatic
induction of TLR2 synthesis indicating that TLR4
signaling in adipocytes induces TLR2 production.
indirect
indirect
PMID: 17681884,17090751,10823826
Stimulation with bacterial LPS, yeast cell wall zymosan or
TNF of murine and human adipocytes leads to a dramatic
induction of TLR2 synthesis indicating that TLR4
signaling in adipocytes induces TLR2 production.
indirect
indirect
PMID: 17681884,17090751,10823826
Stimulation with bacterial LPS, yeast cell wall zymosan or
TNF of murine and human adipocytes leads to a dramatic
induction of TLR2 synthesis indicating that TLR4
signaling in adipocytes induces TLR2 production.
indirect
indirect
PMID: 17681884,17062773
Moreover, in human adipocytes, the proinflammatory
adipokine resistin induces TLR2 protein
expression
PMID: 17681884
Interestingly, there is also evidence for a dichotomy of the
gC1q–receptor interaction because there are two high- and
low-affinity receptors for gC1q and full-length adiponectin:
AdipoR1 and AdipoR2 (adiponectin receptors type 1 and
type 2).
PMID: 17681884
Interestingly, there is also evidence for a dichotomy of the
gC1q–receptor interaction because there are two high- and
low-affinity receptors for gC1q and full-length adiponectin:
AdipoR1 and AdipoR2 (adiponectin receptors type 1 and
type 2).
PMID: 17681884
Interestingly, there is also evidence for a dichotomy of the
gC1q–receptor interaction because there are two high- and
low-affinity receptors for gC1q and full-length adiponectin:
AdipoR1 and AdipoR2 (adiponectin receptors type 1 and
type 2).
PMID: 17681884
Interestingly, there is also evidence for a dichotomy of the
gC1q–receptor interaction because there are two high- and
low-affinity receptors for gC1q and full-length adiponectin:
AdipoR1 and AdipoR2 (adiponectin receptors type 1 and
type 2).
indirect
PMID: 17681884,12802337
These receptors can mediate both adiponectin- and
gC1q-induced activation of adenosine monophosphateactivated
kinase (AMPK) and p38 mitogen-activated
protein kinase (p38 MAPK) and phosphorylation of ACC
(acetyl-CoA-carboxylase)
indirect
PMID: 17681884,12802337
These receptors can mediate both adiponectin- and
gC1q-induced activation of adenosine monophosphateactivated
kinase (AMPK) and p38 mitogen-activated
protein kinase (p38 MAPK) and phosphorylation of ACC
(acetyl-CoA-carboxylase)
indirect
PMID: 17681884,12802337
These receptors can mediate both adiponectin- and
gC1q-induced activation of adenosine monophosphateactivated
kinase (AMPK) and p38 mitogen-activated
protein kinase (p38 MAPK) and phosphorylation of ACC
(acetyl-CoA-carboxylase)
indirect
PMID: 17681884,12802337
These receptors can mediate both adiponectin- and
gC1q-induced activation of adenosine monophosphateactivated
kinase (AMPK) and p38 mitogen-activated
protein kinase (p38 MAPK) and phosphorylation of ACC
(acetyl-CoA-carboxylase)
indirect
PMID: 17681884,12802337
These receptors can mediate both adiponectin- and
gC1q-induced activation of adenosine monophosphateactivated
kinase (AMPK) and p38 mitogen-activated
protein kinase (p38 MAPK) and phosphorylation of ACC
(acetyl-CoA-carboxylase)
indirect
PMID: 17681884,12802337
These receptors can mediate both adiponectin- and
gC1q-induced activation of adenosine monophosphateactivated
kinase (AMPK) and p38 mitogen-activated
protein kinase (p38 MAPK) and phosphorylation of ACC
(acetyl-CoA-carboxylase)
indirect
PMID: 17681884,12802337
These receptors can mediate both adiponectin- and
gC1q-induced activation of adenosine monophosphateactivated
kinase (AMPK) and p38 mitogen-activated
protein kinase (p38 MAPK) and phosphorylation of ACC
(acetyl-CoA-carboxylase)
indirect
PMID: 17681884,12802337
These receptors can mediate both adiponectin- and
gC1q-induced activation of adenosine monophosphateactivated
kinase (AMPK) and p38 mitogen-activated
protein kinase (p38 MAPK) and phosphorylation of ACC
(acetyl-CoA-carboxylase)
indirect
indirect
indirect
indirect
indirect
indirect
PMID: 17681884,16806199
CTRP-1 is expressed in preadipocytes and
upregulated dramatically in rat adipose tissue on LPS
stimulation and in adipose tissue of murine models with
genetically determined obesity
PMID: 17681884,16806199
This LPS effect was
mediated by TNF and IL-1b and both of these proinflammatory
mediators can induce CTRP-1 expression
in adipocytes.
indirect
PMID: 17681884,16806199
CTRP-1 is expressed in preadipocytes and
upregulated dramatically in rat adipose tissue on LPS
stimulation and in adipose tissue of murine models with
genetically determined obesity
PMID: 17681884,16806199
This LPS effect was
mediated by TNF and IL-1b and both of these proinflammatory
mediators can induce CTRP-1 expression
in adipocytes.
indirect
PMID: 17681884,15231994
CTRP-2, the mouse paralog most
similar to adiponectin, enhances glycogen accumulation
and fatty acid oxidation in myotubes by activating the
AMPK signaling pathway
indirect
PMID: 17681884,15231994
CTRP-2, the mouse paralog most
similar to adiponectin, enhances glycogen accumulation
and fatty acid oxidation in myotubes by activating the
AMPK signaling pathway
indirect
PMID: 17681884,16650001
CTRP-3 stimulates
the proliferation of mesenchymal chondroprogenitor cells
through the activation of ERK1/2 and Akt
indirect
PMID: 17681884,16650001
CTRP-3 stimulates
the proliferation of mesenchymal chondroprogenitor cells
through the activation of ERK1/2 and Akt
indirect
PMID: 17681884,16650001
CTRP-3 stimulates
the proliferation of mesenchymal chondroprogenitor cells
through the activation of ERK1/2 and Akt
PMID: 17681884,17311679
CTRP-3 is a
secreted protein, can be detected in human serum and
forms stable trimers
PMID: 17681884,17299102
Moreover, PPARg activation
exerts anti-inflammatory effects and PPARg can bind
specifically to the CTRP-3 promoter and inhibit CTRP-3
gene expression when activated by troglitazone, an exogenous
PPARg activator
indirect
PMID: 17681884,17299102
Moreover, PPARg activation
exerts anti-inflammatory effects and PPARg can bind
specifically to the CTRP-3 promoter and inhibit CTRP-3
gene expression when activated by troglitazone, an exogenous
PPARg activator