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indirect</csml:comment>
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PMID: 17669557, 15240011, 15991247, 16935468, 10501190
In astrocytes, BK induced expression of matrix metalloproteinase-9, phospholipase A2 and COX-2 and increased expression and secretion of IL-6</csml:comment>
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PMID: 17669557
Bradykinin binds to receptor BDKRB1.</csml:comment>
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PMID: 17669557, 15240011, 15991247, 16935468, 10501190
In astrocytes, BK induced expression of matrix metalloproteinase-9, phospholipase A2 and COX-2 and increased expression and secretion of IL-6</csml:comment>
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PMID: 17669557, 15240011, 15991247, 16935468, 10501190
In astrocytes, BK induced expression of matrix metalloproteinase-9, phospholipase A2 and COX-2 and increased expression and secretion of IL-6</csml:comment>
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PMID: 17669557, 15240011, 15991247, 16935468, 10501190
In astrocytes, BK induced expression of matrix metalloproteinase-9, phospholipase A2 and COX-2 and increased expression and secretion of IL-6.</csml:comment>
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PMID: 17669557, 15240011, 15991247, 16935468, 10501190
In astrocytes, BK induced expression of matrix metalloproteinase-9, phospholipase A2 and COX-2 and increased expression and secretion of IL-6.</csml:comment>
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PMID: 17669557
LPS binds TLR4.</csml:comment>
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PMID: 17669557, 17402969
BK receptors in microglia mediate anti-inflammatory or neuroprotective effects, namely the inhibition of LPS-induced release of TNF-&#945; and IL-1&#946;.</csml:comment>
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PMID: 17669557, 17402969
BK receptors in microglia mediate anti-inflammatory or neuroprotective effects, namely the inhibition of LPS-induced release of TNF-&#945; and IL-1&#946;.

PMID: 17669557
BK-induced attenuation of LPS-induced TNF-&#945; formation was suppressed by 10 &#956;M NS398, a cyclooxygenase-2 (COX-2) inhibitor, and 50 &#956;M RpcAMP, a membrane-permeable cAMP inhibitor.</csml:comment>
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PMID: 17669557, 17402969
BK receptors in microglia mediate anti-inflammatory or neuroprotective effects, namely the inhibition of LPS-induced release of TNF-&#945; and IL-1&#946;.</csml:comment>
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PMID: 17669557, 17402969
BK receptors in microglia mediate anti-inflammatory or neuroprotective effects, namely the inhibition of LPS-induced release of TNF-&#945; and IL-1&#946;.</csml:comment>
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PMID: 17669557
BK-induced Ca2+ rises in primary cultured microglia were observed. </csml:comment>
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PMID: 17669557
ATP binds to receptor P2X and P2Y.</csml:comment>
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PMID: 17669557
ATP evoked an increase of [Ca2+] even in cells which did not respond to BK, suggesting that the majority of cultured microglial cells possess ATP receptors while only a minority have functional BK receptors.</csml:comment>
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PMID: 17669557
ATP evoked an increase of [Ca2+] even in cells which did not respond to BK, suggesting that the majority of cultured microglial cells possess ATP receptors while only a minority have functional BK receptors.
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PMID: 17669557
ATP binds to receptor P2X and P2Y.</csml:comment>
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PMID: 17669557
The immunocytochemical analysis using a specific antibody against iNOS showed stronger expression of iNOS in BK-treated microglia identified by isolectin B4-labeling.</csml:comment>
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PMID: 17669557
The immunocytochemical analysis using a specific antibody against iNOS showed stronger expression of iNOS in BK-treated microglia identified by isolectin B4-labeling.

PMID: 17669557
This increase was prevented by the treatment of the cells with 10 &#956;M BAPTA-AM, a membrane-permeable Ca2+ chelator, hinting to a link between BK induced Ca2+ signaling and iNOS expression.</csml:comment>
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PMID: 17669557, 12551746, 15145558
In microglia, the inducible expression of B1 was shown by application of LPS and BK.</csml:comment>
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<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
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<csml:comments>
<csml:comment type="text">

PMID: 17669557, 12551746, 15145558
In microglia, the inducible expression of B1 was shown by application of LPS and BK.</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p21" name="p21" type="cso30:c:ProcessBiological">
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<csml:comment type="text">

indirect</csml:comment>
</csml:comments>
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<csml:connector id="c56" name="c56" refID="MO000021939" type="cso30:c:OutputProcess">
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</csml:comment>
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</csml:processKinetic>
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<csml:comments>
<csml:comment type="text">

PMID: 17669557
PGE2 release was also increased in astrocytes after application of LPS or BK.
</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p22" name="p22" type="cso30:c:ProcessBiological">
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<csml:comments>
<csml:comment type="text">

indirect</csml:comment>
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<csml:comments>
<csml:comment type="text">

PMID: 17669557
PGE2 release was also increased in astrocytes after application of LPS or BK.</csml:comment>
</csml:comments>
</csml:process>
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<csml:comments>
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indirect</csml:comment>
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<csml:comments>
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</csml:comment>
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<csml:comments>
<csml:comment type="text">

PMID: 17669557
BK also up-regulated mRNA for neurotrophic factors such as nerve growth factor (NGF).</csml:comment>
</csml:comments>
</csml:process>
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<csml:comments>
<csml:comment type="text">

indirect</csml:comment>
</csml:comments>
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<csml:comments>
<csml:comment type="text">
</csml:comment>
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<csml:priority value="0"/>
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<csml:parameter key="coefficient1" value="0.1"/>
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</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
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<csml:shape shapeID="default" visible="true">
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<csml:comments>
<csml:comment type="text">

PMID: 17669557
BK and ET, but not substance P (SubP) at concentration of 100 nM increased the mRNA level for NGF.</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p25" name="p25" type="cso30:c:ProcessBiological">
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<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
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<figure>
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<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
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<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
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<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c65" name="c65" refID="e26" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
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</csml:connectorKinetic>
</csml:connectorSimulationProperty>
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<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="447.0" y="1377.0"/>
<csml:shape shapeID="default" visible="true">
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<csml:toolSpecificGraphics xmlns="http://www.csml.org/csml/cigraphics"/>
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<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_Binding" refCellComponentID="cso30:i:CC_Extracellular">
<csml:property key="relationType" value="Type 0"/>
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</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">

PMID: 17669557
Endothelin-1 binds to its receptor.</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p26" name="p26" type="cso30:c:ProcessBiological">
<csml:connector id="c68" name="c68" refID="e11" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
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</csml:connectorSimulationProperty>
<csml:viewProperty>
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<figure>
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indirect</csml:comment>
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PMID: 17669557
We also observed up-regulation of brain-derived neurotrophic factor (BDNF) mRNA level.</csml:comment>
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PMID: 17669557
The amount of NGF was significantly increased by 100 nM BK after 6 h, but not after 3 h of incubation in accordance with the time course of up-regulation of NGF mRNA level.</csml:comment>
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<csml:comment type="text">

</csml:comment>
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