Entity
IKK{active}
--
MO000000248
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m207
10
infinite
0
TRANSPATH | MO000000248 |
--
IRF-8
--
MO000007185
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m769
10
infinite
0
InterPro | IPR008984 |
TRANSPATH | MO000007185 |
--
IRF-1
--
MO000007685
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m970
10
infinite
0
InterPro | IPR001346 |
TRANSPATH | MO000007685 |
--
IRF-2
--
MO000007690
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m974
10
infinite
0
InterPro | IPR001346 |
TRANSPATH | MO000007690 |
--
IRF-3
--
MO000007694
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m977
10
infinite
0
InterPro | IPR008984 |
TRANSPATH | MO000007694 |
--
IRF-4
--
MO000007697
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m978
10
infinite
0
InterPro | IPR008984 |
TRANSPATH | MO000007697 |
--
IRF-7
--
MO000007702
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m980
10
infinite
0
TRANSPATH | MO000007702 |
--
IKK-i{active}
--
MO000016608
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m1599
10
infinite
0
InterPro | IPR000719 |
TRANSPATH | MO000016608 |
--
CBP
--
MO000017462
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m2282
10
infinite
0
InterPro | IPR000433 |
TRANSPATH | MO000017462 |
--
TBK1
--
MO000019331
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m3902
10
infinite
0
InterPro | IPR000719 |
TRANSPATH | MO000019331 |
--
protein remnants
--
MO000019479
cso30:c:Protein
cso30:i:CC_CellComponent
--
--
csml-variable:Double
m360980
10
infinite
0
TRANSPATH | MO000019479 |
--
p300
--
MO000019984
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m4512
10
infinite
0
InterPro | IPR000433 |
TRANSPATH | MO000019984 |
--
p/CAF
--
MO000023551
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m7326
10
infinite
0
InterPro | IPR001487 |
TRANSPATH | MO000023551 |
--
IRF-3{p}
--
MO000041456
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m19324
10
infinite
0
TRANSPATH | MO000041456 |
--
IRF-7{p}
--
MO000041457
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m19325
10
infinite
0
TRANSPATH | MO000041457 |
--
PML
--
MO000045015
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m22678
10
infinite
0
TRANSPATH | MO000045015 |
--
--
e1
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane
--
--
--
csml-variable:Double
m1
0
infinite
0
--
--
e10
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytosol
--
--
--
csml-variable:Double
m10
0
infinite
0
--
IFN
--
e11
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m11
0
infinite
0
--
csml-variable:Double
m12
0
infinite
0
--
IFN:IFNR:JAK
--
e15
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m15
0
infinite
0
--
IRF9
--
e16
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m16
0
infinite
0
--
Stat1:Stat2:IRF9
--
e17
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m17
0
infinite
0
--
csml-variable:Double
m18
0
infinite
0
--
csml-variable:Double
m19
0
infinite
0
--
--
e2
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m2
0
infinite
0
--
IFN stimulated genes
--
e20
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
--
csml-variable:Double
m20
0
infinite
0
--
PU.1:IRF-4
--
e21
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m21
0
infinite
0
--
csml-variable:Double
m22
0
infinite
0
--
csml-variable:Double
m23
0
infinite
0
--
PU.1:IRF-8
--
e24
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m24
0
infinite
0
--
csml-variable:Double
m25
0
infinite
0
--
lysosomal protease
--
e26
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
--
csml-variable:Double
m26
0
infinite
0
--
endosomal protease
--
e27
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
--
csml-variable:Double
m27
0
infinite
0
--
INK4
--
e28
cso30:c:mRNA
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m28
0
infinite
0
--
IRF-8
--
e29
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m29
0
infinite
0
--
--
e3
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
--
csml-variable:Double
m3
0
infinite
0
--
BCR/Abl protein
--
e30
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m30
0
infinite
0
--
type I interferons
--
e31
cso30:c:mRNA
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m31
0
infinite
0
--
IL-12p40
--
e32
cso30:c:mRNA
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m32
0
infinite
0
--
ligand:TLRs
--
e33
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m33
0
infinite
0
--
(IRF-3{p})2
--
e35
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m35
0
infinite
0
--
(IRF-3{p})2
--
e36
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m36
0
infinite
0
--
IFN-alpha
--
e37
cso30:c:mRNA
cso30:i:CC_Cytosol
--
csml-variable:Double
m37
0
infinite
0
--
IFN-beta
--
e38
cso30:c:mRNA
cso30:i:CC_Cytosol
--
csml-variable:Double
m38
0
infinite
0
--
(IRF-7{p})2
--
e39
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m39
0
infinite
0
--
--
e4
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m4
0
infinite
0
--
(IRF-7{p})2
--
e40
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m40
0
infinite
0
--
NSP1
--
e41
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m41
0
infinite
0
--
NSP1:IRF-3
--
e42
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m42
0
infinite
0
--
ICP0
--
e43
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m43
0
infinite
0
--
PML:ICP0
--
e44
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m44
0
infinite
0
--
SUMO
--
e45
cso30:c:SmallMolecule
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m45
0
infinite
0
--
PML{sumo}
--
e46
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m46
0
infinite
0
--
P protein
--
e47
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m47
0
infinite
0
--
PML:P protein
--
e48
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m48
0
infinite
0
--
INFR
--
e5
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m5
0
infinite
0
--
--
e50
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelopeLumen
--
--
--
csml-variable:Double
m50
0
infinite
0
--
--
e51
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearPore
--
--
--
csml-variable:Double
m51
0
infinite
0
--
--
e52
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearInnerMembrane
--
--
--
csml-variable:Double
m52
0
infinite
0
--
--
e53
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearLumen
--
--
--
csml-variable:Double
m53
0
infinite
0
--
--
e54
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearOuterMembrane
--
--
--
csml-variable:Double
m54
0
infinite
0
--
--
e55
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleus
--
--
--
csml-variable:Double
m55
0
infinite
0
--
--
e56
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleoplasm
--
--
--
csml-variable:Double
m56
0
infinite
0
--
--
e57
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearBody
--
--
--
csml-variable:Double
m57
0
infinite
0
--
--
e58
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleolus
--
--
--
csml-variable:Double
m58
0
infinite
0
--
--
e59
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelope
--
--
--
csml-variable:Double
m59
0
infinite
0
--
IFN:IFNR
--
e6
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m6
0
infinite
0
--
--
e60
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Chromatin
--
--
--
csml-variable:Double
m60
0
infinite
0
--
--
e61
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearChromosome
--
--
--
csml-variable:Double
m61
0
infinite
0
--
--
e62
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearCentromere
--
--
--
csml-variable:Double
m62
0
infinite
0
--
IRF-8{p}
--
e63
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m63
0
infinite
0
--
RIG-I:ligand
--
e65
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m65
0
infinite
0
--
IRF-1{ace}
--
e67
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m67
0
infinite
0
--
IRF-7{ace}
--
e68
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m68
0
infinite
0
--
IRF-2{ace}
--
e69
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m69
0
infinite
0
--
--
e7
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell
--
--
--
csml-variable:Double
m7
0
infinite
0
--
IRF-3:pin1
--
e70
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m70
0
infinite
0
--
IRF-8:TRAF6
--
e71
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m71
0
infinite
0
--
IRF-8{ub}:TRAF6
--
e72
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m72
0
infinite
0
--
IRF-7{ub}
--
e73
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m73
0
infinite
0
--
--
e8
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell_WithoutCellWall_
--
--
--
csml-variable:Double
m8
0
infinite
0
--
--
e9
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytoplasm
--
--
--
csml-variable:Double
m9
0
infinite
0
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1
m11*m5*0.1
nodelay
--
0
PMID: 17502370 Following IFN-receptor interaction, a latent cytoplasmic IRF-9 complexes with Stat1 and Stat2 through the activation of the JAK/STAT pathway, binds to the IFN-stimulated response element (ISRE), and stimulates transcription of a large set of IFN-stimulated genes.
p10
p10
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c29 : 1
stoichiometry:c30 : 1
m769*m15836*0.1
nodelay
--
0
PMID: 17502370, 15947094, 12453417, 11846986 They not only bind the ISRE, the binding site for all IRF factors, but also bind various Ets/IRF composite elements through their interaction with PU.1, an Ets family transcription factor
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c33 : 1
stoichiometry:c32 : 1
m24*m22*0.1
nodelay
--
0
PMID: 17502370, 15947094, 12453417, 11846986 They not only bind the ISRE, the binding site for all IRF factors, but also bind various Ets/IRF composite elements through their interaction with PU.1, an Ets family transcription factor
p12
p12
cso30:i:CE_CellDifferentiation
cso30:i:CC_Cytosol
--
--
PMID: 17502370, 11846985 IRF-8 coordinates myeloid cell growth and differentiation. PMID: 17502370 IRF-8 promotes macrophage differentiation while inhibiting granulocyte development.
PMID: 17502370, 11846985 IRF-8 coordinates myeloid cell growth and differentiation
p14
p14
cso30:i:ME_GeneExpression
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c36 : 1
stoichiometry:c37 : 1
m769*0.1
nodelay
--
0
PMID: 17502370, 15947094 It directly stimulates the expression of genes active in macrophages including those for lysosomal and endosomal proteases.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c39 : 1
stoichiometry:c38 : 1
m769*0.1
nodelay
--
0
PMID: 17502370, 15947094 It directly stimulates the expression of genes active in macrophages including those for lysosomal and endosomal proteases.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1
m769*0.1
nodelay
--
0
PMID: 17502370 In myeloid cells IRF-8 negatively regulates cell growth as it inhibits c-myc and stimulates expression of tumor suppressor/inhibitor of cyclin-dependent kinase (INK4).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c42 : 1
1.0*0.1
nodelay
--
0
PMID: 17502370, 11846985 This growth regulation is relevant to CML in humans, where IRF-8 expression is down-regulated by the Bcr/Abl oncoprotein resulting in abnormal growth promotion.
p18
p18
cso30:i:ME_GeneExpression
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c48 : 1
stoichiometry:c44 : 1
m769*0.1
nodelay
--
0
PMID: 17502370, 15728463, 10861061 IRF-8, but not IRF-4, is required for the expression of proinflammatory cytokines including type I IFN and IL-12p40, indicating that IRF-8 is critically required for cytokine gene expression. PMID: 17502370, 16236719 IRF-4, on the other hand, inhibits expression of proinflammatory cytokine genes.
p19
p19
cso30:i:ME_GeneExpression
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c49 : 1
stoichiometry:c46 : 1
m769*0.1
nodelay
--
0
PMID: 17502370, 15728463, 10861061 IRF-8, but not IRF-4, is required for the expression of proinflammatory cytokines including type I IFN and IL-12p40, indicating that IRF-8 is critically required for cytokine gene expression. PMID: 17502370, 16236719 IRF-4, on the other hand, inhibits expression of proinflammatory cytokine genes.
p2
p2
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c11 : 1
stoichiometry:c8 : 1
m1357*m15*0.1
nodelay
--
0
PMID: 17502370 Following IFN-receptor interaction, a latent cytoplasmic IRF-9 complexes with Stat1 and Stat2 through the activation of the JAK/STAT pathway, binds to the IFN-stimulated response element (ISRE), and stimulates transcription of a large set of IFN-stimulated genes.
p20
p20
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c54 : 1
stoichiometry:c51 : 1
m977*m207*0.1
nodelay
--
0
PMID: 17502370 Upon activation, IRF-3 and IRF-7 are phosphorylated through the I{kappa}B kinase (IKK) family of kinases, dimerized, and translocated into the nucleus to stimulate IFNbeta and IFN{alpha} transcription.
p21
p21
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c59 : 1
stoichiometry:c53 : 1
m34*m33*0.1
nodelay
--
0
PMID: 17502370 RF-3 and IRF-7 are early IRFs activated by Toll-like receptor (TLR)and other types of signaling that play a pivotal role in the initial induction of type I IFNs. PMID: 17502370 Upon activation, IRF-3 and IRF-7 are phosphorylated through the I{kappa}B kinase (IKK) family of kinases, dimerized, and translocated into the nucleus to stimulate IFNbeta and IFN{alpha} transcription.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c56 : 1
m19324*0.1
nodelay
--
0
PMID: 17502370 Upon activation, IRF-3 and IRF-7 are phosphorylated through the I{kappa}B kinase (IKK) family of kinases, dimerized, and translocated into the nucleus to stimulate IFNbeta and IFN{alpha} transcription.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c57 : 1
stoichiometry:c58 : 1
m35*0.1
nodelay
--
0
PMID: 17502370 Upon activation, IRF-3 and IRF-7 are phosphorylated through the I{kappa}B kinase (IKK) family of kinases, dimerized, and translocated into the nucleus to stimulate IFNbeta and IFN{alpha} transcription.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c61 : 1
m36*0.1
nodelay
--
0
PMID: 17502370 Upon activation, IRF-3 and IRF-7 are phosphorylated through the I{kappa}B kinase (IKK) family of kinases, dimerized, and translocated into the nucleus to stimulate IFNbeta and IFN{alpha} transcription.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c63 : 1
stoichiometry:c62 : 1
m36*0.1
nodelay
--
0
PMID: 17502370 Upon activation, IRF-3 and IRF-7 are phosphorylated through the I{kappa}B kinase (IKK) family of kinases, dimerized, and translocated into the nucleus to stimulate IFNbeta and IFN{alpha} transcription.
p26
p26
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c64 : 1
stoichiometry:c66 : 1
stoichiometry:c65 : 1
m980*m207*0.1
nodelay
--
0
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c68 : 1
m19325*0.1
nodelay
--
0
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c70 : 1
m39*0.1
nodelay
--
0
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c71 : 1
stoichiometry:c72 : 1
m40*0.1
nodelay
--
0
PMID: 17502370 Upon activation, IRF-3 and IRF-7 are phosphorylated through the I{kappa}B kinase (IKK) family of kinases, dimerized, and translocated into the nucleus to stimulate IFNbeta and IFN{alpha} transcription.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1
m6*m12*0.1
nodelay
--
0
PMID: 17502370 Following IFN-receptor interaction, a latent cytoplasmic IRF-9 complexes with Stat1 and Stat2 through the activation of the JAK/STAT pathway, binds to the IFN-stimulated response element (ISRE), and stimulates transcription of a large set of IFN-stimulated genes.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c73 : 1
m40*0.1
nodelay
--
0
PMID: 17502370 Upon activation, IRF-3 and IRF-7 are phosphorylated through the I{kappa}B kinase (IKK) family of kinases, dimerized, and translocated into the nucleus to stimulate IFNbeta and IFN{alpha} transcription.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c75 : 1
stoichiometry:c76 : 1
stoichiometry:c77 : 1
m977*m41*0.1
nodelay
--
0
PMID: 17502370, 15741273 the rotavirus regulatory protein NSP1 binds to and degrades IRF-3 to disable IFN induction.
p32
p32
cso30:i:ME_UnknownDegradation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c78 : 1
stoichiometry:c79 : 1
stoichiometry:c80 : 1
m42*0.1
nodelay
--
0
PMID: 17502370, 15741273 the rotavirus regulatory protein NSP1 binds to and degrades IRF-3 to disable IFN induction.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c81 : 1
stoichiometry:c82 : 1
stoichiometry:c83 : 1
m22678*m43*0.1
nodelay
--
0
PMID: 17502370 ICP0 interacts with PML and affects SUMO (small ubiquitin-related modifier) modification of PML, thereby counteracting PML inhibition of viral replication.
p34
p34
cso30:i:ME_Sumoylation
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c85 : 1
stoichiometry:c87 : 1
stoichiometry:c86 : 1
m22678*m45*0.1
nodelay
--
0
PMID: 17502370 ICP0 interacts with PML and affects SUMO (small ubiquitin-related modifier) modification of PML, thereby counteracting PML inhibition of viral replication.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c88 : 1
stoichiometry:c89 : 1
stoichiometry:c90 : 1
m47*m22678*0.1
nodelay
--
0
PMID: 17502370, 16689655 Additionally, infection with rabies virus, an RNA virus, also alters PML distribution through the interaction of the viral P protein with PML
p36
p36
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c91 : 1
stoichiometry:c93 : 1
stoichiometry:c94 : 1
stoichiometry:c92 : 1
m49*0.1
nodelay
--
0
PMID: 17502370, 16914719 IRF-8 is phosphorylated at the tyrosine residues in the DBD, which is inhibited by the protein tyrosine phosphatases SHP1 and SHP2.
p37
p37
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c95 : 1
stoichiometry:c97 : 1
stoichiometry:c96 : 1
m977*m3902*0.1
nodelay
--
0
PMID: 17502370, 16979567, 16932750 TLR- and retinoic acid inducible gene-I (RIG-I)-mediated phosphorylation of IRF-3 and IRF-7 by IKKi/{epsilon} and Tank-binding kinase-1 (TBK-1) is a prerequisite of IFN induction.
p38
p38
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c98 : 1
stoichiometry:c100 : 1
stoichiometry:c99 : 1
m977*m1599*0.1
nodelay
--
0
PMID: 17502370, 16979567, 16932750 TLR- and retinoic acid inducible gene-I (RIG-I)-mediated phosphorylation of IRF-3 and IRF-7 by IKKi/{epsilon} and Tank-binding kinase-1 (TBK-1) is a prerequisite of IFN induction.
p39
p39
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c101 : 1
stoichiometry:c103 : 1
stoichiometry:c102 : 1
m64*m65*0.1
nodelay
--
0
PMID: 17502370, 16979567, 16932750 TLR- and retinoic acid inducible gene-I (RIG-I)-mediated phosphorylation of IRF-3 and IRF-7 by IKKi/{epsilon} and Tank-binding kinase-1 (TBK-1) is a prerequisite of IFN induction.
p4
p4
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c9 : 1
stoichiometry:c12 : 1
stoichiometry:c10 : 1
m1358*m15*0.1
nodelay
--
0
PMID: 17502370 Following IFN-receptor interaction, a latent cytoplasmic IRF-9 complexes with Stat1 and Stat2 through the activation of the JAK/STAT pathway, binds to the IFN-stimulated response element (ISRE), and stimulates transcription of a large set of IFN-stimulated genes.
p40
p40
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c104 : 1
stoichiometry:c106 : 1
stoichiometry:c105 : 1
m64*m33*0.1
nodelay
--
0
PMID: 17502370, 16979567, 16932750 TLR- and retinoic acid inducible gene-I (RIG-I)-mediated phosphorylation of IRF-3 and IRF-7 by IKKi/{epsilon} and Tank-binding kinase-1 (TBK-1) is a prerequisite of IFN induction.
p41
p41
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c107 : 1
stoichiometry:c109 : 1
stoichiometry:c108 : 1
m66*m65*0.1
nodelay
--
0
PMID: 17502370, 16979567, 16932750 TLR- and retinoic acid inducible gene-I (RIG-I)-mediated phosphorylation of IRF-3 and IRF-7 by IKKi/{epsilon} and Tank-binding kinase-1 (TBK-1) is a prerequisite of IFN induction.
p42
p42
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c110 : 1
stoichiometry:c112 : 1
stoichiometry:c111 : 1
m66*m33*0.1
nodelay
--
0
PMID: 17502370, 16979567, 16932750 TLR- and retinoic acid inducible gene-I (RIG-I)-mediated phosphorylation of IRF-3 and IRF-7 by IKKi/{epsilon} and Tank-binding kinase-1 (TBK-1) is a prerequisite of IFN induction.
p43
p43
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c113 : 1
stoichiometry:c115 : 1
stoichiometry:c114 : 1
m980*m3902*0.1
nodelay
--
0
PMID: 17502370, 16979567, 16932750 TLR- and retinoic acid inducible gene-I (RIG-I)-mediated phosphorylation of IRF-3 and IRF-7 by IKKi/{epsilon} and Tank-binding kinase-1 (TBK-1) is a prerequisite of IFN induction.
p44
p44
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c116 : 1
stoichiometry:c118 : 1
stoichiometry:c117 : 1
m980*m1599*0.1
nodelay
--
0
PMID: 17502370, 16979567, 16932750 TLR- and retinoic acid inducible gene-I (RIG-I)-mediated phosphorylation of IRF-3 and IRF-7 by IKKi/{epsilon} and Tank-binding kinase-1 (TBK-1) is a prerequisite of IFN induction.
p45
p45
cso30:i:ME_Acetylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c119 : 1
stoichiometry:c121 : 1
stoichiometry:c120 : 1
m970*m7326*0.1
nodelay
--
0
PMID: 17502370, 12374802, 12738767 IRF-1, -2, and -7 are acetylated by histone acetylases GCN/PCAF and CBP/p300.
p46
p46
cso30:i:ME_Acetylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c122 : 1
stoichiometry:c124 : 1
stoichiometry:c123 : 1
m970*m4512*0.1
nodelay
--
0
PMID: 17502370, 12374802, 12738767 IRF-1, -2, and -7 are acetylated by histone acetylases GCN/PCAF and CBP/p300.
p47
p47
cso30:i:ME_Acetylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c125 : 1
stoichiometry:c127 : 1
stoichiometry:c126 : 1
m970*m2282*0.1
nodelay
--
0
PMID: 17502370, 12374802, 12738767 IRF-1, -2, and -7 are acetylated by histone acetylases GCN/PCAF and CBP/p300.
p48
p48
cso30:i:ME_Acetylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c128 : 1
stoichiometry:c129 : 1
stoichiometry:c130 : 1
m980*m7326*0.1
nodelay
--
0
PMID: 17502370, 12374802, 12738767 IRF-1, -2, and -7 are acetylated by histone acetylases GCN/PCAF and CBP/p300.
p49
p49
cso30:i:ME_Acetylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c131 : 1
stoichiometry:c133 : 1
stoichiometry:c132 : 1
m980*m4512*0.1
nodelay
--
0
PMID: 17502370, 12374802, 12738767 IRF-1, -2, and -7 are acetylated by histone acetylases GCN/PCAF and CBP/p300.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1
stoichiometry:c16 : 1
m14*m13*m16*0.1
nodelay
--
0
PMID: 17502370 Following IFN-receptor interaction, a latent cytoplasmic IRF-9 complexes with Stat1 and Stat2 through the activation of the JAK/STAT pathway, binds to the IFN-stimulated response element (ISRE), and stimulates transcription of a large set of IFN-stimulated genes.
p50
p50
cso30:i:ME_Acetylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c134 : 1
stoichiometry:c136 : 1
stoichiometry:c135 : 1
m980*m2282*0.1
nodelay
--
0
PMID: 17502370, 12374802, 12738767 IRF-1, -2, and -7 are acetylated by histone acetylases GCN/PCAF and CBP/p300.
p51
p51
cso30:i:ME_Acetylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c137 : 1
stoichiometry:c139 : 1
stoichiometry:c138 : 1
m974*m4512*0.1
nodelay
--
0
PMID: 17502370, 12374802, 12738767 IRF-1, -2, and -7 are acetylated by histone acetylases GCN/PCAF and CBP/p300.
p52
p52
cso30:i:ME_Acetylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c140 : 1
stoichiometry:c142 : 1
stoichiometry:c141 : 1
m974*m7326*0.1
nodelay
--
0
PMID: 17502370, 12374802, 12738767 IRF-1, -2, and -7 are acetylated by histone acetylases GCN/PCAF and CBP/p300.
p53
p53
cso30:i:ME_Acetylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c143 : 1
stoichiometry:c145 : 1
stoichiometry:c144 : 1
m974*m2282*0.1
nodelay
--
0
PMID: 17502370, 12374802, 12738767 IRF-1, -2, and -7 are acetylated by histone acetylases GCN/PCAF and CBP/p300.
p54
p54
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c146 : 1
stoichiometry:c147 : 1
stoichiometry:c148 : 1
m2065*m19324*0.1
nodelay
--
0
PMID: 17502370, 16699525 The peptidylprolyl isomerase Pin1 interacts with IRF-3 and changes the isomerization status in a phosphorylation-dependent manner, leading to rapid destabilization of IRF-3.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c149 : 1
stoichiometry:c150 : 1
stoichiometry:c152 : 1
stoichiometry:c151 : 1
m183*m49*m33*0.1
nodelay
--
0
PMID: 17502370, 16484229 In a separate study, TRAF6 was shown to associate with IRF-8 in TLR-stimulated macrophages, consistent with the involvement of IRF-8 in ubiquitination-coupled transcription.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c153 : 1
stoichiometry:c154 : 1
m71*0.1
nodelay
--
0
PMID: 17502370, 16484229 In a separate study, TRAF6 was shown to associate with IRF-8 in TLR-stimulated macrophages, consistent with the involvement of IRF-8 in ubiquitination-coupled transcription.
p57
p57
cso30:i:ME_Ubiquitination
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c155 : 1
stoichiometry:c157 : 1
stoichiometry:c158 : 1
stoichiometry:c156 : 1
m980*m183*m33*0.1
nodelay
--
0
PMID: 17502370, 15361868 IRF-7 is ubiquitinated upon TLR stimulation through an E3 ubiquitin ligase, TRAF6.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c159 : 1
stoichiometry:c160 : 1
m29*0.1
nodelay
--
0
PMID: 17502370, 11846985 This growth regulation is relevant to CML in humans, where IRF-8 expression is down-regulated by the Bcr/Abl oncoprotein resulting in abnormal growth promotion.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c17 : 1
stoichiometry:c18 : 1
stoichiometry:c19 : 1
m18*m17*0.1
nodelay
--
0
PMID: 17502370 Following IFN-receptor interaction, a latent cytoplasmic IRF-9 complexes with Stat1 and Stat2 through the activation of the JAK/STAT pathway, binds to the IFN-stimulated response element (ISRE), and stimulates transcription of a large set of IFN-stimulated genes.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c20 : 1
stoichiometry:c21 : 1
m19*0.1
nodelay
--
0
PMID: 17502370 Following IFN-receptor interaction, a latent cytoplasmic IRF-9 complexes with Stat1 and Stat2 through the activation of the JAK/STAT pathway, binds to the IFN-stimulated response element (ISRE), and stimulates transcription of a large set of IFN-stimulated genes.
p8
p8
cso30:i:ME_Binding
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1
m978*m15836*0.1
nodelay
--
0
PMID: 17502370, 15947094, 12453417, 11846986 They not only bind the ISRE, the binding site for all IRF factors, but also bind various Ets/IRF composite elements through their interaction with PU.1, an Ets family transcription factor
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1
m21*m22*0.1
nodelay
--
0
PMID: 17502370, 15947094, 12453417, 11846986 They not only bind the ISRE, the binding site for all IRF factors, but also bind various Ets/IRF composite elements through their interaction with PU.1, an Ets family transcription factor
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--