Entity
Process
IL-6
--
G010262
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m93248
10
infinite
0
TRANSFAC | G010262 |
--
IL-1beta
--
G010389
cso30:c:mRNA
cso30:i:CC_CellComponent
--
csml-variable:Double
m93364
10
infinite
0
TRANSFAC | G010389 |
--
ERK
--
MO000000011
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m179
10
infinite
0
--
p38{active}
--
MO000000022
cso30:c:Protein
cso30:i:CC_CellComponent
--
--
csml-variable:Double
m120
10
infinite
0
TRANSPATH | MO000000022 |
--
csml-variable:Double
m217
10
infinite
0
--
csml-variable:Double
m181
10
infinite
0
--
NF-kappaB
--
MO000000058
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m129
10
infinite
0
TRANSPATH | MO000000058 |
--
TNF
--
MO000000204
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m175
10
infinite
0
TRANSPATH | MO000000204 |
--
IL-1
--
MO000000214
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m185
10
infinite
0
TRANSPATH | MO000000214 |
--
Class A GPCR
--
MO000000314
cso30:c:Protein
cso30:i:CC_CellComponent
--
--
csml-variable:Double
m249
10
infinite
0
TRANSPATH | MO000000314 |
--
ERK1
--
MO000004670
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m549
10
infinite
0
InterPro | IPR000719 |
TRANSPATH | MO000004670 |
--
ERK2
--
MO000004676
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m554
10
infinite
0
InterPro | IPR000719 |
TRANSPATH | MO000004676 |
--
IL-6
--
MO000007384
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m871
10
infinite
0
InterPro | IPR003573 |
TRANSPATH | MO000007384 |
--
STAT1
--
MO000013119
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m1357
10
infinite
0
InterPro | IPR008967 |
TRANSPATH | MO000013119 |
--
PAR1 precursor
--
MO000013668
cso30:c:Protein
cso30:i:CC_CellComponent
--
--
csml-variable:Double
m1420
10
infinite
0
InterPro | IPR000276 |
TRANSPATH | MO000013668 |
--
IL-1alpha
--
MO000016589
cso30:c:Protein
cso30:i:CC_CellComponent
--
--
csml-variable:Double
m1584
10
infinite
0
InterPro | IPR008996 |
TRANSPATH | MO000016589 |
--
IL-1beta
--
MO000016597
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m1591
10
infinite
0
TRANSPATH | MO000016597 |
--
LPS
--
MO000016882
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m155666
10
infinite
0
TRANSPATH | MO000016882 |
--
thrombin
--
MO000017008
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m1909
10
infinite
0
InterPro | IPR009003 |
TRANSPATH | MO000017008 |
--
PAR2 precursor
--
MO000017020
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m1920
10
infinite
0
InterPro | IPR000276 |
TRANSPATH | MO000017020 |
--
GRK
--
MO000017069
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m1961
10
infinite
0
TRANSPATH | MO000017069 |
--
beta-arrestin
--
MO000017072
cso30:c:Protein
cso30:i:CC_CellComponent
--
--
csml-variable:Double
m1964
10
infinite
0
TRANSPATH | MO000017072 |
--
beta-arrestin1
--
MO000017073
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m1965
10
infinite
0
InterPro | IPR000698 |
TRANSPATH | MO000017073 |
--
beta-arrestin2
--
MO000017074
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m1966
10
infinite
0
InterPro | IPR000698 |
TRANSPATH | MO000017074 |
--
GRK2
--
MO000017093
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m1984
10
infinite
0
--
CXCR4
--
MO000017157
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m2033
10
infinite
0
InterPro | IPR000276 |
TRANSPATH | MO000017157 |
--
IL-10
--
MO000017247
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m2103
10
infinite
0
InterPro | IPR000098 |
TRANSPATH | MO000017247 |
--
IL-8
--
MO000017264
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m2120
10
infinite
0
InterPro | IPR002473 |
TRANSPATH | MO000017264 |
--
MCP-1
--
MO000017280
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m2133
10
infinite
0
InterPro | IPR008097 |
TRANSPATH | MO000017280 |
--
CCR5
--
MO000017281
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m2134
10
infinite
0
InterPro | IPR000276 |
TRANSPATH | MO000017281 |
--
PAR2{active}
--
MO000017394
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m2226
10
infinite
0
InterPro | IPR000276 |
TRANSPATH | MO000017394 |
--
JNK3
--
MO000017818
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m2570
10
infinite
0
--
PAR1{active}
--
MO000018417
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m3055
10
infinite
0
InterPro | IPR000276 |
TRANSPATH | MO000018417 |
--
NADPH oxidase
--
MO000021432
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m5783
10
infinite
0
TRANSPATH | MO000021432 |
--
FPRL1
--
MO000063316
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m38196
10
infinite
0
TRANSPATH | MO000063316 |
--
--
e1
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane
--
--
--
csml-variable:Double
m1
0
infinite
0
--
--
e10
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytosol
--
--
--
csml-variable:Double
m10
0
infinite
0
--
LTB4:LTB4R2
--
e100
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m101
0
infinite
0
--
NADPH oxidase{active}
--
e101
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m102
10
infinite
0
TRANSPATH | MO000021432 |
--
IL-12
--
e102
cso30:c:mRNA
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m103
0
infinite
0
--
IL-10
--
e103
cso30:c:mRNA
cso30:i:CC_Cytosol
--
csml-variable:Double
m104
0
infinite
0
--
IP-10
--
e104
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
--
csml-variable:Double
m105
0
infinite
0
--
CCL22
--
e105
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
--
csml-variable:Double
m106
0
infinite
0
--
CCL22
--
e106
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m107
0
infinite
0
--
CCR4:CCL22
--
e107
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m108
0
infinite
0
--
EMR2
--
e108
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m109
0
infinite
0
--
EMR1
--
e109
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m110
0
infinite
0
--
GDP: alpha Gprotein
--
e11
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m11
0
infinite
0
--
Chondroitin sulfate
--
e110
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m111
0
infinite
0
--
CD97:Chondroitin sulfate
--
e111
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m112
0
infinite
0
--
EMR2:Chondroitin sulfate
--
e112
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m113
0
infinite
0
--
proteoglycan
--
e113
cso30:c:SmallMolecule
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m114
0
infinite
0
--
EMR1:Proteoglycan
--
e114
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m115
0
infinite
0
--
PTx
--
e115
cso30:c:SmallMolecule
cso30:i:CC_Cytosol
--
csml-variable:Double
m116
0
infinite
0
--
Galpha i2
--
e116
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m117
0
infinite
0
--
Galpha i2{p}
--
e117
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m118
0
infinite
0
--
Beta-gamma: GDP:alpha Gprotein
--
e12
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m12
0
infinite
0
--
ERK1{active}
--
e120
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m122
10
infinite
0
InterPro | IPR000719 |
TRANSPATH | MO000004670 |
--
ERK2{active}
--
e121
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m123
10
infinite
0
InterPro | IPR000719 |
TRANSPATH | MO000004676 |
--
Galpha i1
--
e123
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m125
0
infinite
0
--
Galpha i3
--
e124
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m126
0
infinite
0
--
Thromnaxane B2 protein
--
e125
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m127
0
infinite
0
--
Thrombaxane B2
--
e126
cso30:c:mRNA
cso30:i:CC_Cytosol
--
csml-variable:Double
m128
0
infinite
0
--
NF-kappaB{active}
--
e127
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m130
10
infinite
0
TRANSPATH | MO000000058 |
--
C3a:C3aR
--
e128
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m131
0
infinite
0
--
Ligand:CXCR2
--
e129
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m132
0
infinite
0
--
Class A GPCR: Chemokine
--
e13
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m13
0
infinite
0
--
Ligand:FPR
--
e130
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m133
0
infinite
0
--
IL-8:IL-8R
--
e131
cso30:c:Complex
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m134
0
infinite
0
--
GBeta2L1
--
e132
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m135
0
infinite
0
--
IFN-alpha:receptor
--
e133
cso30:c:Complex
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m136
0
infinite
0
--
IFN-alpha:receptor:STAT1
--
e134
cso30:c:Complex
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m137
0
infinite
0
--
IFN-beta:receptor
--
e135
cso30:c:Complex
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m138
0
infinite
0
--
IFN-beta:receptor:STAT1
--
e136
cso30:c:Complex
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m139
0
infinite
0
--
IGF:IGFR-1
--
e137
cso30:c:Complex
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m140
0
infinite
0
--
IGF-IGFR1:STAT3
--
e138
cso30:c:Complex
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m141
0
infinite
0
--
RGS7
--
e139
cso30:c:mRNA
cso30:i:CC_Cytosol
--
csml-variable:Double
m142
0
infinite
0
--
Class A GPCR:Chemokine:Beta-gamma:GDP:alpha G protein
--
e14
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m14
0
infinite
0
--
GIPC
--
e140
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m143
0
infinite
0
--
RGS19:GIPC
--
e141
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m144
0
infinite
0
--
IGFR1
--
e142
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m145
0
infinite
0
--
IGFR1:RGS19:GIPC
--
e143
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m146
0
infinite
0
--
RGS19:GIPC:TrkA
--
e145
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m148
0
infinite
0
--
GRK2
--
e146
cso30:c:mRNA
cso30:i:CC_Cytosol
--
csml-variable:Double
m149
0
infinite
0
--
GRK5
--
e147
cso30:c:mRNA
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m150
0
infinite
0
--
--
e148
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearOuterMembrane
--
--
--
csml-variable:Double
m151
0
infinite
0
--
--
e149
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearLumen
--
--
--
csml-variable:Double
m152
0
infinite
0
--
Class A GPCR:Chemokine:Beta-gamma:GTP:alpha G protein
--
e15
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m15
0
infinite
0
--
--
e150
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleoplasm
--
--
--
csml-variable:Double
m153
0
infinite
0
--
--
e151
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleus
--
--
--
csml-variable:Double
m154
0
infinite
0
--
--
e152
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleolus
--
--
--
csml-variable:Double
m155
0
infinite
0
--
--
e153
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelope
--
--
--
csml-variable:Double
m156
0
infinite
0
--
--
e154
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelopeLumen
--
--
--
csml-variable:Double
m157
0
infinite
0
--
--
e155
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearPore
--
--
--
csml-variable:Double
m158
0
infinite
0
--
--
e156
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearBody
--
--
--
csml-variable:Double
m159
0
infinite
0
--
--
e157
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearChromosome
--
--
--
csml-variable:Double
m160
0
infinite
0
--
--
e158
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Chromatin
--
--
--
csml-variable:Double
m161
0
infinite
0
--
--
e159
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearCentromere
--
--
--
csml-variable:Double
m162
0
infinite
0
--
Chemokine:Class A GPCR:Beta-gamma G protein
--
e16
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m16
0
infinite
0
--
--
e160
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearInnerMembrane
--
--
--
csml-variable:Double
m163
0
infinite
0
--
GRK6
--
e161
cso30:c:mRNA
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m164
0
infinite
0
--
IFN
--
e162
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m165
0
infinite
0
--
Synucleins
--
e164
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m167
0
infinite
0
--
Synucleins{p}
--
e165
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m168
0
infinite
0
--
Phosducin
--
e166
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m169
0
infinite
0
--
Phosducin{p}
--
e167
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m170
0
infinite
0
--
csml-variable:Double
m171
0
infinite
0
--
GRK:PI3K
--
e169
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m172
0
infinite
0
--
GTP:alpha G protein
--
e17
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m17
0
infinite
0
--
GAP
--
e170
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m173
0
infinite
0
--
GRK:GAP
--
e171
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m174
0
infinite
0
--
Galphaq
--
e172
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m176
0
infinite
0
--
Galphaq:GRK
--
e173
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m177
0
infinite
0
--
Beta Gamma G protein:GRK
--
e174
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m178
0
infinite
0
--
GRK:ERK
--
e175
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m180
0
infinite
0
--
GRK:AKT
--
e176
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m182
0
infinite
0
--
GRK2:G beta Gamma
--
e177
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m183
0
infinite
0
--
GRK3
--
e178
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m184
0
infinite
0
--
GRK3:Beta Gamma G protein
--
e179
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m186
0
infinite
0
--
Chemokine:Class A GPCR{p}:Beta-gamma G protein
--
e18
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m18
0
infinite
0
--
Galphaq:GRK3
--
e180
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m187
0
infinite
0
--
Galphaq:GRK2
--
e181
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m188
0
infinite
0
--
p105
--
e182
cso30:c:Protein
cso30:i:CC_Nucleoplasm
--
--
csml-variable:Double
m189
0
infinite
0
--
GRK5:p105
--
e183
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m190
0
infinite
0
--
GRK5:p105{p}
--
e184
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m191
0
infinite
0
--
SRC
--
e185
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m192
0
infinite
0
--
RAF-1
--
e186
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m193
0
infinite
0
--
Beta arrestin2:RAF-1:SRC
--
e187
cso30:c:Complex
cso30:i:CC_Extracellular
--
csml-variable:Double
m194
0
infinite
0
--
Ligand:CXCR4
--
e188
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m195
0
infinite
0
--
ERK{active}
--
e189
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m196
10
infinite
0
--
second messenger dependent protein kinase
--
e19
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m19
0
infinite
0
--
Ligand:PAR-2
--
e190
cso30:c:Complex
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m197
0
infinite
0
--
Ligand:Beta 2 adrenergic receptor
--
e191
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m198
0
infinite
0
--
Ligand:Angiotensin II type IA
--
e192
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m199
0
infinite
0
--
beta-arrestin:ERK
--
e193
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m200
0
infinite
0
--
csml-variable:Double
m201
10
infinite
0
--
beta arrestin:ERK{p}
--
e195
cso30:c:Complex
cso30:i:CC_Extracellular
--
csml-variable:Double
m202
0
infinite
0
--
beta-arrestin
--
e196
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m203
10
infinite
0
TRANSPATH | MO000017072 |
--
csml-variable:Double
m204
10
infinite
0
--
CSF-1
--
e198
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m205
0
infinite
0
--
CSF-1{active}
--
e199
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m206
0
infinite
0
--
--
e2
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m2
0
infinite
0
--
beta-arrestin1
--
e20
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m20
10
infinite
0
InterPro | IPR000698 |
TRANSPATH | MO000017073 |
--
JNK3:beta arrestin2
--
e200
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m207
0
infinite
0
--
ASK1
--
e201
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m208
0
infinite
0
--
JNK3:beta arrestin 2: ASK1
--
e202
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m209
0
infinite
0
--
beta-arrestin:NF-kappaB
--
e203
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m210
0
infinite
0
--
IKappaB-alpha
--
e204
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m211
0
infinite
0
--
beta arrestin1:IKappaB-alpha
--
e205
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m212
0
infinite
0
--
beta arrestin2:IkkapB-alpha
--
e206
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m213
0
infinite
0
--
NF-kappaB{active}
--
e207
cso30:c:Protein
cso30:i:CC_CellComponent
--
--
csml-variable:Double
m214
10
infinite
0
TRANSPATH | MO000000058 |
--
csml-variable:Double
m215
0
infinite
0
--
NF-KappaB{active}:DNA
--
e209
cso30:c:Complex
cso30:i:CC_Nucleoplasm
--
--
csml-variable:Double
m216
0
infinite
0
--
beta-arrestin2
--
e21
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m21
10
infinite
0
InterPro | IPR000698 |
TRANSPATH | MO000017074 |
--
TRAF6
--
e210
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m218
0
infinite
0
--
TRAF6{ub}
--
e211
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m220
0
infinite
0
--
TRAF6{ub} oligomer
--
e212
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m221
0
infinite
0
--
csml-variable:Double
m222
10
infinite
0
--
IKK{active}
--
e214
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m223
0
infinite
0
--
IKK
--
e215
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m224
0
infinite
0
--
LPS:TLR4
--
e216
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
csml-variable:Double
m225
0
infinite
0
--
IL-1:IL-1R
--
e217
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m226
0
infinite
0
--
beta arrestin1:TRAF6
--
e218
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m227
0
infinite
0
--
beta arrestin2:TRAF6
--
e219
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m228
0
infinite
0
--
Class B GPCR: Chemokine
--
e23
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m23
0
infinite
0
--
Class B GPCR:Chemokine:Beta-gamma:GDP:alpha G protein
--
e24
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m24
0
infinite
0
--
Class B GPCR:Chemokine:Beta-gamma:GTP:alpha G protein
--
e25
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m25
0
infinite
0
--
Chemokine:Class B GPCR:Beta-gamma G protein
--
e26
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m26
0
infinite
0
--
Chemokine:Class B GPCR{p}:Beta-gamma G protein
--
e27
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m27
0
infinite
0
--
Chemokine: Calss A GPCR{p}:Beta-gamma G protein:Beta arrestin2
--
e28
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m28
0
infinite
0
--
Chemokine: Calss B GPCR{p}:Beta-gamma G protein:Beta arrestin1
--
e29
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m29
0
infinite
0
--
--
e3
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
--
csml-variable:Double
m3
0
infinite
0
--
Chemokine: Calss B GPCR{p}:Beta-gamma G protein:Beta arrestin2
--
e30
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m30
0
infinite
0
--
Chemokine: Calss A GPCR{p}:Beta-gamma G protein:Beta arrestin1
--
e31
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m31
0
infinite
0
--
Chemokine:Class A GPCR{p}:Beta-gamma G protein
--
e32
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m32
0
infinite
0
--
Chemokine: Calss B GPCR{p}:Beta-gamma G protein:Beta arrestin2
--
e33
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m33
0
infinite
0
--
Chemokine: Calss B GPCR{p}:Beta-gamma G protein:Beta arrestin1
--
e34
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m34
0
infinite
0
--
C5a:C5aR
--
e35
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m35
0
infinite
0
--
CD88
--
e36
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m36
0
infinite
0
--
C5a:CD88
--
e37
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m37
0
infinite
0
--
Superoxide anion
--
e38
cso30:c:SmallMolecule
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m38
0
infinite
0
--
PGE2
--
e39
cso30:c:SmallMolecule
cso30:i:CC_Cytosol
--
csml-variable:Double
m39
0
infinite
0
--
--
e4
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m4
0
infinite
0
--
IL-1
--
e40
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m40
0
infinite
0
--
TNF
--
e41
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m41
0
infinite
0
--
FPR1
--
e42
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m42
0
infinite
0
--
N-formylated methionine
--
e43
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m43
0
infinite
0
--
FPR1: N-formylated methionine
--
e44
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m44
0
infinite
0
--
fMLP
--
e45
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m45
0
infinite
0
--
FPR1: fMLP
--
e46
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m46
0
infinite
0
--
FPRL1:fMLP
--
e47
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m47
0
infinite
0
--
endogenous ligand
--
e48
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m48
0
infinite
0
--
FPRL2: endogenous ligand
--
e49
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m49
0
infinite
0
--
Beta Gamma Grotein
--
e5
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m5
0
infinite
0
--
--
e50
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelopeLumen
--
--
--
csml-variable:Double
m50
0
infinite
0
--
--
e51
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearPore
--
--
--
csml-variable:Double
m51
0
infinite
0
--
--
e52
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearInnerMembrane
--
--
--
csml-variable:Double
m52
0
infinite
0
--
--
e53
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearLumen
--
--
--
csml-variable:Double
m53
0
infinite
0
--
--
e54
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearOuterMembrane
--
--
--
csml-variable:Double
m54
0
infinite
0
--
--
e55
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleus
--
--
--
csml-variable:Double
m55
0
infinite
0
--
--
e56
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleoplasm
--
--
--
csml-variable:Double
m56
0
infinite
0
--
--
e57
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearBody
--
--
--
csml-variable:Double
m57
0
infinite
0
--
--
e58
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleolus
--
--
--
csml-variable:Double
m58
0
infinite
0
--
--
e59
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelope
--
--
--
csml-variable:Double
m59
0
infinite
0
--
Chemokine
--
e6
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m6
0
infinite
0
--
--
e60
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Chromatin
--
--
--
csml-variable:Double
m60
0
infinite
0
--
--
e61
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearChromosome
--
--
--
csml-variable:Double
m61
0
infinite
0
--
--
e62
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearCentromere
--
--
--
csml-variable:Double
m62
0
infinite
0
--
Nonformylated bacterial protein
--
e63
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m63
0
infinite
0
--
FPR1: Nonformylated bacterial protein
--
e64
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m64
0
infinite
0
--
FPRL1: Nonformylated bacterial protein
--
e65
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m65
0
infinite
0
--
annexin 1
--
e66
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m66
0
infinite
0
--
FPR1:aneexin1
--
e67
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m67
0
infinite
0
--
FPLR1:annexin 1
--
e68
cso30:c:Complex
cso30:i:CC_NuclearEnvelopeLumen
--
--
csml-variable:Double
m68
0
infinite
0
--
Serum amyloid A
--
e69
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m69
0
infinite
0
--
--
e7
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell
--
--
--
csml-variable:Double
m7
0
infinite
0
--
Serum amyloid A: FPR1
--
e70
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m70
0
infinite
0
--
Serum amyloid A: FPRL1
--
e71
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m71
0
infinite
0
--
amyloid beta peptide
--
e72
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m72
0
infinite
0
--
amyloid beta peptide: FPR1
--
e73
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m73
0
infinite
0
--
amyloid beta peptide: FPRL1
--
e74
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m74
0
infinite
0
--
NO
--
e75
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m75
0
infinite
0
--
PARs
--
e78
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m78
0
infinite
0
--
PARs{active}
--
e79
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m79
0
infinite
0
--
--
e8
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell_WithoutCellWall_
--
--
--
csml-variable:Double
m8
0
infinite
0
--
IL-1alpha
--
e80
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
--
csml-variable:Double
m80
0
infinite
0
--
PAR2 receptor activating peptides
--
e81
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m81
0
infinite
0
--
IL-8
--
e82
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m82
0
infinite
0
--
NK-1R
--
e83
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m83
0
infinite
0
--
SP
--
e84
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m84
0
infinite
0
--
NK-1R:SP
--
e85
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m85
0
infinite
0
--
ROS
--
e86
cso30:c:SmallMolecule
cso30:i:CC_Cytosol
--
csml-variable:Double
m86
0
infinite
0
--
PGD2
--
e87
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m87
0
infinite
0
--
SP
--
e88
cso30:c:mRNA
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m88
0
infinite
0
--
ET-1:receptor
--
e89
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m89
0
infinite
0
--
--
e9
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytoplasm
--
--
--
csml-variable:Double
m9
0
infinite
0
--
cox-2
--
e90
cso30:c:mRNA
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m90
0
infinite
0
--
GM-CSF
--
e91
cso30:c:mRNA
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m92
0
infinite
0
--
ET-1:ETAR
--
e92
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m93
0
infinite
0
--
ET-2:receptor
--
e93
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
csml-variable:Double
m94
0
infinite
0
--
MMp2
--
e94
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m95
0
infinite
0
--
MMp9
--
e95
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m96
0
infinite
0
--
superoxide
--
e96
cso30:c:SmallMolecule
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m97
0
infinite
0
--
02-
--
e97
cso30:c:SmallMolecule
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m98
0
infinite
0
--
PAF:PAFR
--
e98
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m99
0
infinite
0
--
LTB4:LTB4R1
--
e99
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m100
0
infinite
0
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1
m5*m11*0.1
nodelay
--
0
PMID: 17456803 In the absence of agonist, the Beta{gamma}-subunit associates with the GDP-bound {alpha}-subunit.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1
m22*m6*0.1
nodelay
--
0
PMID: 17456803 Figure 1
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c277 : 1
stoichiometry:c278 : 1
stoichiometry:c279 : 1
m111*m109*0.1
nodelay
--
0
PMID: 17456803,12829604 In humans, EMR2 and CD97 were identified as receptors for cell surface chondroitin sulfate , suggesting that the ligand for EMR1 may be a proteoglycan.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c280 : 1
stoichiometry:c281 : 1
stoichiometry:c282 : 1
m110*m114*0.1
nodelay
--
0
PMID: 17456803,12829604 In humans, EMR2 and CD97 were identified as receptors for cell surface chondroitin sulfate , suggesting that the ligand for EMR1 may be a proteoglycan.
p102
p102
cso30:i:ME_Translation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c283 : 1
stoichiometry:c285 : 1
stoichiometry:c286 : 1
stoichiometry:c284 : 1
m40*m155666*0.1
nodelay
--
0
PMID: 17456803,3095921 Jakway and DeFranco first showed that pretreatment of the macrophage cell line P388D1 with PTx reduced the production of IL-1 in response to LPS.
p103
p103
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c287 : 1
stoichiometry:c288 : 1
stoichiometry:c289 : 1
m155666*m117*0.1
nodelay
--
0
PMID: 17456803,2511200 Further, LPS stimulation caused G{alpha}i2 phosphorylation in these cells, implicating this G-protein as a player in LPS signaling
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c290 : 1
stoichiometry:c292 : 1
stoichiometry:c291 : 1
m155666*0.1
nodelay
--
0
PMID: 17456803,8423328,2844658 In mouse peritoneal macrophages, PTx inhibited LPS-dependent NO production but amplified TNF protein production, although others reported no effect of this inhibitor on TNF secretion
p105
p105
cso30:i:ME_Translation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c293 : 1
stoichiometry:c295 : 1
stoichiometry:c296 : 1
stoichiometry:c294 : 1
m41*m155666*m116*0.1
nodelay
--
0
p106
p106
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c297 : 1
stoichiometry:c299 : 1
stoichiometry:c300 : 1
stoichiometry:c298 : 1
m121*m155666*0.1
nodelay
--
0
PMID: 17456803,15201703,12701623,11303728 At the level of signaling, PTx reduced LPS-mediated activation of p38, ERK1/2 and AP-1, without affecting NF-{kappa}B activation
p106
p107
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c301 : 1
stoichiometry:c304 : 1
stoichiometry:c308 : 1
stoichiometry:c441 : 1
stoichiometry:c305 : 1
m155666*m549*0.1
nodelay
--
0
PMID: 17456803,15201703,12701623,11303728 At the level of signaling, PTx reduced LPS-mediated activation of p38, ERK1/2 and AP-1, without affecting NF-{kappa}B activation
p106
p108
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c302 : 1
stoichiometry:c306 : 1
stoichiometry:c309 : 1
stoichiometry:c442 : 1
stoichiometry:c307 : 1
m155666*m554*0.1
nodelay
--
0
PMID: 17456803,15201703,12701623,11303728 At the level of signaling, PTx reduced LPS-mediated activation of p38, ERK1/2 and AP-1, without affecting NF-{kappa}B activation
p106
p109
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c303 : 1
stoichiometry:c310 : 1
stoichiometry:c311 : 1
stoichiometry:c312 : 1
m155666*m219*0.1
nodelay
--
0
PMID: 17456803,15201703,12701623,11303728 At the level of signaling, PTx reduced LPS-mediated activation of p38, ERK1/2 and AP-1, without affecting NF-{kappa}B activation
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c29 : 1
stoichiometry:c30 : 1
m23*m12*0.1
nodelay
--
0
PMID: 17456803 Agonist occupation of GPCRs stimulates a change in conformation of the receptor, which couples the receptor to the G-protein and promotes the exchange of GDP for GTP on the {alpha}-subunit.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c313 : 1
stoichiometry:c315 : 1
stoichiometry:c314 : 1
m41*m126*0.1
nodelay
--
0
PMID: 17456803,15788486 For example, LPS-induced TNF, IL-10 and thrombaxane B2 protein production was reduced in peritoneal macrophages derived from mice lacking G{alpha}i2 or G{alpha}i1/3
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c316 : 1
stoichiometry:c318 : 1
stoichiometry:c317 : 1
m41*m117*0.1
nodelay
--
0
PMID: 17456803,15788486 For example, LPS-induced TNF, IL-10 and thrombaxane B2 protein production was reduced in peritoneal macrophages derived from mice lacking G{alpha}i2 or G{alpha}i1/3
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c319 : 1
stoichiometry:c320 : 1
stoichiometry:c321 : 1
m125*m41*0.1
nodelay
--
0
PMID: 17456803,15788486 For example, LPS-induced TNF, IL-10 and thrombaxane B2 protein production was reduced in peritoneal macrophages derived from mice lacking G{alpha}i2 or G{alpha}i1/3
p110
p113
cso30:i:ME_Translation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c322 : 1
stoichiometry:c323 : 1
stoichiometry:c324 : 1
m104*m125*0.1
nodelay
--
0
PMID: 17456803,15788486 For example, LPS-induced TNF, IL-10 and thrombaxane B2 protein production was reduced in peritoneal macrophages derived from mice lacking G{alpha}i2 or G{alpha}i1/3
p110
p114
cso30:i:ME_Translation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c325 : 1
stoichiometry:c326 : 1
stoichiometry:c327 : 1
m104*m117*0.1
nodelay
--
0
PMID: 17456803,15788486 For example, LPS-induced TNF, IL-10 and thrombaxane B2 protein production was reduced in peritoneal macrophages derived from mice lacking G{alpha}i2 or G{alpha}i1/3
p110
p115
cso30:i:ME_Translation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c328 : 1
stoichiometry:c329 : 1
stoichiometry:c330 : 1
m104*m126*0.1
nodelay
--
0
PMID: 17456803,15788486 For example, LPS-induced TNF, IL-10 and thrombaxane B2 protein production was reduced in peritoneal macrophages derived from mice lacking G{alpha}i2 or G{alpha}i1/3
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c331 : 1
stoichiometry:c333 : 1
stoichiometry:c332 : 1
m128*m126*0.1
nodelay
--
0
PMID: 17456803,15788486 For example, LPS-induced TNF, IL-10 and thrombaxane B2 protein production was reduced in peritoneal macrophages derived from mice lacking G{alpha}i2 or G{alpha}i1/3
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c334 : 1
stoichiometry:c335 : 1
stoichiometry:c336 : 1
m128*m125*0.1
nodelay
--
0
PMID: 17456803,15788486 For example, LPS-induced TNF, IL-10 and thrombaxane B2 protein production was reduced in peritoneal macrophages derived from mice lacking G{alpha}i2 or G{alpha}i1/3
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c337 : 1
stoichiometry:c338 : 1
m128*m117*0.1
nodelay
--
0
PMID: 17456803,15788486 For example, LPS-induced TNF, IL-10 and thrombaxane B2 protein production was reduced in peritoneal macrophages derived from mice lacking G{alpha}i2 or G{alpha}i1/3
p119
p119
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c339 : 1
stoichiometry:c340 : 1
stoichiometry:c341 : 1
m35*m129*0.1
nodelay
--
0
PMID: 17456803,10233875,8316840,8486684,11359849 While PTx-sensitive G-proteins can regulate GPCR and TLR signaling in macrophages, PTx-insensitive G-proteins appear to occupy a more conventional signaling role by coupling several chemotactic GPCRs [e.g., CXCR2, C5aR, C3aR, FPR and the IL-8 receptor (IL-8R)] to activation of NF-{kappa}B
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1
m24*0.1
nodelay
--
0
PMID: 17456803 Agonist occupation of GPCRs stimulates a change in conformation of the receptor, which couples the receptor to the G-protein and promotes the exchange of GDP for GTP on the {alpha}-subunit.
p119
p120
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c342 : 1
stoichiometry:c343 : 1
stoichiometry:c344 : 1
m131*m129*0.1
nodelay
--
0
PMID: 17456803,10233875,8316840,8486684,11359849 While PTx-sensitive G-proteins can regulate GPCR and TLR signaling in macrophages, PTx-insensitive G-proteins appear to occupy a more conventional signaling role by coupling several chemotactic GPCRs [e.g., CXCR2, C5aR, C3aR, FPR and the IL-8 receptor (IL-8R)] to activation of NF-{kappa}B
p119
p121
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c345 : 1
stoichiometry:c346 : 1
stoichiometry:c347 : 1
m132*m129*0.1
nodelay
--
0
PMID: 17456803,10233875,8316840,8486684,11359849 While PTx-sensitive G-proteins can regulate GPCR and TLR signaling in macrophages, PTx-insensitive G-proteins appear to occupy a more conventional signaling role by coupling several chemotactic GPCRs [e.g., CXCR2, C5aR, C3aR, FPR and the IL-8 receptor (IL-8R)] to activation of NF-{kappa}B
p119
p122
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c348 : 1
stoichiometry:c349 : 1
stoichiometry:c350 : 1
m133*m129*0.1
nodelay
--
0
PMID: 17456803,10233875,8316840,8486684,11359849 While PTx-sensitive G-proteins can regulate GPCR and TLR signaling in macrophages, PTx-insensitive G-proteins appear to occupy a more conventional signaling role by coupling several chemotactic GPCRs [e.g., CXCR2, C5aR, C3aR, FPR and the IL-8 receptor (IL-8R)] to activation of NF-{kappa}B
p119
p123
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c351 : 1
stoichiometry:c352 : 1
stoichiometry:c353 : 1
m134*m129*0.1
nodelay
--
0
PMID: 17456803,10233875,8316840,8486684,11359849 While PTx-sensitive G-proteins can regulate GPCR and TLR signaling in macrophages, PTx-insensitive G-proteins appear to occupy a more conventional signaling role by coupling several chemotactic GPCRs [e.g., CXCR2, C5aR, C3aR, FPR and the IL-8 receptor (IL-8R)] to activation of NF-{kappa}B
p124
p124
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c354 : 1
stoichiometry:c355 : 1
stoichiometry:c359 : 1
stoichiometry:c356 : 1
m135*m136*m1357*0.1
nodelay
--
0
PMID: 17456803,11046044,11301323,16382134 Gbeta2L1 also has roles beyond regulation of GPCR signaling; it mediated the recruitment of STAT1 and STAT3 to the IFN-{alpha}/beta and the tyrosine kinase insulin-like growth factor receptor 1 (IGFR-1) receptors, respectively
p124
p125
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c357 : 1
stoichiometry:c358 : 1
stoichiometry:c360 : 1
stoichiometry:c361 : 1
m138*m135*m1357*0.1
nodelay
--
0
PMID: 17456803,11046044,11301323,16382134 Gbeta2L1 also has roles beyond regulation of GPCR signaling; it mediated the recruitment of STAT1 and STAT3 to the IFN-{alpha}/beta and the tyrosine kinase insulin-like growth factor receptor 1 (IGFR-1) receptors, respectively
p124
p126
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c362 : 1
stoichiometry:c363 : 1
stoichiometry:c365 : 1
stoichiometry:c364 : 1
m140*m135*m1360*0.1
nodelay
--
0
PMID: 17456803,11046044,11301323,16382134 Gbeta2L1 also has roles beyond regulation of GPCR signaling; it mediated the recruitment of STAT1 and STAT3 to the IFN-{alpha}/beta and the tyrosine kinase insulin-like growth factor receptor 1 (IGFR-1) receptors, respectively
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c366 : 1
stoichiometry:c367 : 1
m155666*0.1
nodelay
--
0
PMID: 17456803,11886441 In addition, Hausmann et al. showed that LPS and TNF increased RGS7 mRNA levels markedly in the macrophage-like cell line RAW264.7
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c368 : 1
stoichiometry:c369 : 1
m175*0.1
nodelay
--
0
PMID: 17456803,11886441 In addition, Hausmann et al. showed that LPS and TNF increased RGS7 mRNA levels markedly in the macrophage-like cell line RAW264.7
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c370 : 1
stoichiometry:c371 : 1
stoichiometry:c372 : 1
m44517*m143*0.1
nodelay
--
0
PMID: 17456803, 9770488 RGS19 [also known as Galpha-interacting protein (GAIP) interacts specifically with the PDZ-containing protein, GAIP-interacting protein, C-terminus (GIPC)
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c33 : 1
stoichiometry:c34 : 1
stoichiometry:c35 : 1
m25*0.1
nodelay
--
0
PMID: 17456803 The GTP-bound {alpha}-subunit dissociates from the beta{gamma}-subunit; the free subunits then regulate effector enzymes positively or negatively, ultimately leading to a biological response.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c373 : 1
stoichiometry:c374 : 1
stoichiometry:c375 : 1
m144*m145*0.1
nodelay
--
0
PMID: 17456803, 11751850 Interaction of the RGS19/GIPC heterodimer with the IGFR-1 consolidates IGF-1 signaling to MAPK activation
p131
p131
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c376 : 1
stoichiometry:c377 : 1
stoichiometry:c378 : 1
m146*m1812*0.1
nodelay
--
0
PMID: 17456803, 11751850 Interaction of the RGS19/GIPC heterodimer with the IGFR-1 consolidates IGF-1 signaling to MAPK activation
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c379 : 1
stoichiometry:c380 : 1
stoichiometry:c381 : 1
m144*m1922*0.1
nodelay
--
0
PMID: 17456803, 11251075 RGS19 and GAIC can also form a complex with the nerve growth factor receptor, TrkA, , although it remains unclear how this complex affects signaling through these receptors.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c382 : 1
stoichiometry:c383 : 1
1.0*0.1
nodelay
--
0
PMID: 17456803 Array data suggest that GRK2 and -6 mRNA expression is down-regulated by LPS in bone marrow-derived macrophages
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c385 : 1
stoichiometry:c384 : 1
1.0*0.1
nodelay
--
0
PMID: 17456803 Array data suggest that GRK2 and -6 mRNA expression is down-regulated by LPS in bone marrow-derived macrophages
p135
p135
cso30:i:ME_Translation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c386 : 1
stoichiometry:c391 : 1
stoichiometry:c396 : 1
stoichiometry:c387 : 1
m150*m1591*0.1
nodelay
--
0
PMID: 17456803, 11861327, 12130691, 10094932 Protein expression of GRK2 and -5 was elevated in the lungs of IL-1beta-treated rats while oxygen radicals and the inflammatory cytokines, IL-6 and IFN, reduced GRK2 protein in human T lymphocytes and human PBMC, respectively PMID: 17456803, 12592402 Furthermore, GRK2 and -5 protein expression was down-regulated by LPS in polymorphonuclear neutrophils, thereby augmenting chemokine responsiveness
p135
p136
cso30:i:ME_Translation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c389 : 1
stoichiometry:c392 : 1
stoichiometry:c393 : 1
stoichiometry:c388 : 1
stoichiometry:c394 : 1
stoichiometry:c395 : 1
stoichiometry:c390 : 1
m149*m1591*0.1
nodelay
--
0
PMID: 17456803, 11861327, 12130691, 10094932 Protein expression of GRK2 and -5 was elevated in the lungs of IL-1beta-treated rats while oxygen radicals and the inflammatory cytokines, IL-6 and IFN, reduced GRK2 protein in human T lymphocytes and human PBMC, respectively PMID: 17456803, 11861327, 12130691, 10094932 Protein expression of GRK2 and -5 was elevated in the lungs of IL-1beta-treated rats while oxygen radicals and the inflammatory cytokines, IL-6 and IFN, reduced GRK2 protein in human T lymphocytes and human PBMC, respectively PMID: 17456803, 12592402 Furthermore, GRK2 and -5 protein expression was down-regulated by LPS in polymorphonuclear neutrophils, thereby augmenting chemokine responsiveness
p137
p137
cso30:i:ME_Phosphorylation
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c397 : 1
stoichiometry:c398 : 1
stoichiometry:c399 : 1
m1961*m1967*0.1
nodelay
--
0
PMID: 17456803, 9575184, 10852916, 10884381 First, GRKs are able to phosphorylate nonreceptor substrates such as tubulin, synucleins and phosducin
p137
p138
cso30:i:ME_Phosphorylation
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c400 : 1
stoichiometry:c401 : 1
stoichiometry:c402 : 1
m1961*m167*0.1
nodelay
--
0
PMID: 17456803, 9575184, 10852916, 10884381 First, GRKs are able to phosphorylate nonreceptor substrates such as tubulin, synucleins and phosducin
p137
p139
cso30:i:ME_Phosphorylation
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c403 : 1
stoichiometry:c404 : 1
stoichiometry:c405 : 1
m1961*m169*0.1
nodelay
--
0
PMID: 17456803, 9575184, 10852916, 10884381 First, GRKs are able to phosphorylate nonreceptor substrates such as tubulin, synucleins and phosducin
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c36 : 1
stoichiometry:c37 : 1
stoichiometry:c38 : 1
m1961*m26*0.1
nodelay
--
0
PMID: 17456803,2836733,7876239,10090766 Desensitization is initiated by phosphorylation of activated GPCRs within the third intracellular loop or the carboxyl-terminal tail by GRKs and/or second messenger-dependent protein kinases
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c406 : 1
stoichiometry:c407 : 1
stoichiometry:c408 : 1
m1961*m171*0.1
nodelay
--
0
PMID: 17456803, 12163475, 12885252, 9826657, 10727532, 16221891, 16142243 In addition, GRKs modulate signaling in a phosphorylation-independent manner by interacting with proteins involved in signaling and trafficking, including PI-3Ks, guanosinetriphosphatase-activating protein, Galphaq and Gbetagamma, ERK and AKT
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c409 : 1
stoichiometry:c410 : 1
stoichiometry:c411 : 1
m173*m1961*0.1
nodelay
--
0
PMID: 17456803, 12163475, 12885252, 9826657, 10727532, 16221891, 16142243 In addition, GRKs modulate signaling in a phosphorylation-independent manner by interacting with proteins involved in signaling and trafficking, including PI-3Ks, guanosinetriphosphatase-activating protein, Galphaq and Gbetagamma, ERK and AKT
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c412 : 1
stoichiometry:c413 : 1
stoichiometry:c414 : 1
m1961*m176*0.1
nodelay
--
0
PMID: 17456803, 12163475, 12885252, 9826657, 10727532, 16221891, 16142243 In addition, GRKs modulate signaling in a phosphorylation-independent manner by interacting with proteins involved in signaling and trafficking, including PI-3Ks, guanosinetriphosphatase-activating protein, Galphaq and Gbetagamma, ERK and AKT
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c415 : 1
stoichiometry:c416 : 1
stoichiometry:c417 : 1
m5*m1961*0.1
nodelay
--
0
PMID: 17456803, 12163475, 12885252, 9826657, 10727532, 16221891, 16142243 In addition, GRKs modulate signaling in a phosphorylation-independent manner by interacting with proteins involved in signaling and trafficking, including PI-3Ks, guanosinetriphosphatase-activating protein, Galphaq and Gbetagamma, ERK and AKT
p140
p144
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c418 : 1
stoichiometry:c419 : 1
stoichiometry:c420 : 1
m179*m1961*0.1
nodelay
--
0
PMID: 17456803, 12163475, 12885252, 9826657, 10727532, 16221891, 16142243 In addition, GRKs modulate signaling in a phosphorylation-independent manner by interacting with proteins involved in signaling and trafficking, including PI-3Ks, guanosinetriphosphatase-activating protein, Galphaq and Gbetagamma, ERK and AKT
p140
p145
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c421 : 1
stoichiometry:c422 : 1
stoichiometry:c423 : 1
m181*m1961*0.1
nodelay
--
0
PMID: 17456803, 12163475, 12885252, 9826657, 10727532, 16221891, 16142243 In addition, GRKs modulate signaling in a phosphorylation-independent manner by interacting with proteins involved in signaling and trafficking, including PI-3Ks, guanosinetriphosphatase-activating protein, Galphaq and Gbetagamma, ERK and AKT
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c424 : 1
stoichiometry:c425 : 1
stoichiometry:c426 : 1
m1984*m5*0.1
nodelay
--
0
PMID: 17456803, 10727532, 10567430, 16339447, 10719047 Binding of GRK2 or -3 to the Gbetagamma complex induces activation of these GRKs while selective binding of GRK2 and -3 to activated Galphaq selectively inhibits Galphaq signaling
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c427 : 1
stoichiometry:c428 : 1
stoichiometry:c429 : 1
m5*m184*0.1
nodelay
--
0
PMID: 17456803, 10727532, 10567430, 16339447, 10719047 Binding of GRK2 or -3 to the Gbetagamma complex induces activation of these GRKs while selective binding of GRK2 and -3 to activated Galphaq selectively inhibits Galphaq signaling
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c430 : 1
stoichiometry:c431 : 1
stoichiometry:c432 : 1
m184*m176*0.1
nodelay
--
0
PMID: 17456803, 10727532, 10567430, 16339447, 10719047 Binding of GRK2 or -3 to the Gbetagamma complex induces activation of these GRKs while selective binding of GRK2 and -3 to activated Galphaq selectively inhibits Galphaq signaling
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c433 : 1
stoichiometry:c434 : 1
stoichiometry:c435 : 1
m176*m1984*0.1
nodelay
--
0
PMID: 17456803, 10727532, 10567430, 16339447, 10719047 Binding of GRK2 or -3 to the Gbetagamma complex induces activation of these GRKs while selective binding of GRK2 and -3 to activated Galphaq selectively inhibits Galphaq signaling
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c39 : 1
stoichiometry:c40 : 1
stoichiometry:c41 : 1
m19*m26*0.1
nodelay
--
0
PMID: 17456803,2836733,7876239,10090766 Desensitization is initiated by phosphorylation of activated GPCRs within the third intracellular loop or the carboxyl-terminal tail by GRKs and/or second messenger-dependent protein kinases
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c436 : 1
stoichiometry:c437 : 1
stoichiometry:c438 : 1
m1999*m189*0.1
nodelay
--
0
PMID: 17456803, 16980301 GRK5 also bound to and phosphorylated p105, implying that p105 phosphorylation by GRK5 negatively regulates LPS-stimulated ERK activation
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c439 : 1
stoichiometry:c440 : 1
m190*0.1
nodelay
--
0
p152
p152
cso30:i:ME_Binding
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c443 : 1
stoichiometry:c444 : 1
stoichiometry:c445 : 1
stoichiometry:c446 : 1
m193*m192*m1966*0.1
nodelay
--
0
PMID: 17456803, 12370187, 12821670, 13679574, 11226259, 10725339, 14711824, 9924018 For example, ARRB2 was required for CXCR4, PAR-2, Beta2-adrenergic receptor, and angiotensin II Type 1A-mediated ERK activation via direct binding to components of the ERK pathway such as SRC and RAF-1
p153
p153
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c447 : 1
stoichiometry:c448 : 1
stoichiometry:c449 : 1
stoichiometry:c450 : 1
m195*m194*m179*0.1
nodelay
--
0
PMID: 17456803, 12370187, 12821670, 13679574, 11226259, 10725339, 14711824, 9924018 For example, ARRB2 was required for CXCR4, PAR-2, Beta2-adrenergic receptor, and angiotensin II Type 1A-mediated ERK activation via direct binding to components of the ERK pathway such as SRC and RAF-1
p153
p154
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c451 : 1
stoichiometry:c452 : 1
stoichiometry:c453 : 1
stoichiometry:c454 : 1
m197*m194*m179*0.1
nodelay
--
0
PMID: 17456803, 12370187, 12821670, 13679574, 11226259, 10725339, 14711824, 9924018 For example, ARRB2 was required for CXCR4, PAR-2, Beta2-adrenergic receptor, and angiotensin II Type 1A-mediated ERK activation via direct binding to components of the ERK pathway such as SRC and RAF-1
p153
p155
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c455 : 1
stoichiometry:c456 : 1
stoichiometry:c457 : 1
stoichiometry:c458 : 1
m198*m194*m179*0.1
nodelay
--
0
PMID: 17456803, 12370187, 12821670, 13679574, 11226259, 10725339, 14711824, 9924018 For example, ARRB2 was required for CXCR4, PAR-2, Beta2-adrenergic receptor, and angiotensin II Type 1A-mediated ERK activation via direct binding to components of the ERK pathway such as SRC and RAF-1
p153
p156
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c459 : 1
stoichiometry:c460 : 1
stoichiometry:c461 : 1
stoichiometry:c462 : 1
m199*m194*m179*0.1
nodelay
--
0
PMID: 17456803, 12370187, 12821670, 13679574, 11226259, 10725339, 14711824, 9924018 For example, ARRB2 was required for CXCR4, PAR-2, Beta2-adrenergic receptor, and angiotensin II Type 1A-mediated ERK activation via direct binding to components of the ERK pathway such as SRC and RAF-1
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c464 : 1
stoichiometry:c463 : 1
stoichiometry:c465 : 1
m1964*m201*0.1
nodelay
--
0
PMID: 17456803, 12821670, 10725339 Further, direct binding of ARRB to ERK enhanced ERK phosphorylation and targeted it to the cytosol
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c466 : 1
stoichiometry:c467 : 1
m200*0.1
nodelay
--
0
PMID: 17456803, 12821670, 10725339 Further, direct binding of ARRB to ERK enhanced ERK phosphorylation and targeted it to the cytosol
p159
p159
cso30:i:ME_Translocation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c468 : 1
stoichiometry:c469 : 1
stoichiometry:c470 : 1
m202*0.1
nodelay
--
0
PMID: 17456803, 12821670, 10725339 Further, direct binding of ARRB to ERK enhanced ERK phosphorylation and targeted it to the cytosol
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c42 : 1
stoichiometry:c43 : 1
stoichiometry:c44 : 1
m18*m21*0.1
nodelay
--
0
PMID: 17456803 Class A receptors bind ARRB2 with much higher affinity than ARRB1, and Class B receptors bind both ARRBs with equal affinities.
p160
p160
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c471 : 1
stoichiometry:c473 : 1
stoichiometry:c472 : 1
m2570*m1966*0.1
nodelay
--
0
PMID: 17456803, 11356842 ARRB2, but not ARRB1, activated JNK3 signaling through its ability to act as a scaffold
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c474 : 1
stoichiometry:c475 : 1
m205*0.1
nodelay
--
0
PMID: 17456803, 11756160, 9710599 Activation of a number of receptor tyrosine kinases, including the CSF-1 receptor, which is required for macrophage survival and proliferation , leads to activation of ERK1/2.
p161
p162
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c476 : 1
stoichiometry:c477 : 1
stoichiometry:c478 : 1
m206*m549*0.1
nodelay
--
0
PMID: 17456803, 11756160, 9710599 Activation of a number of receptor tyrosine kinases, including the CSF-1 receptor, which is required for macrophage survival and proliferation , leads to activation of ERK1/2.
p161
p163
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c479 : 1
stoichiometry:c481 : 1
stoichiometry:c480 : 1
m206*m554*0.1
nodelay
--
0
PMID: 17456803, 11756160, 9710599 Activation of a number of receptor tyrosine kinases, including the CSF-1 receptor, which is required for macrophage survival and proliferation , leads to activation of ERK1/2.
p164
p164
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c482 : 1
stoichiometry:c483 : 1
stoichiometry:c484 : 1
m2570*m1966*0.1
nodelay
--
0
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c485 : 1
stoichiometry:c486 : 1
stoichiometry:c487 : 1
m208*m207*0.1
nodelay
--
0
PMID: 17456803 The interaction among JNK3, ARRB2 and ASK1 resulted in the assembly of signaling complexes and enhanced phosphorylation of JNK3.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c488 : 1
stoichiometry:c489 : 1
stoichiometry:c490 : 1
m203*m129*0.1
nodelay
--
0
PMID: 17456803 ARRBs also regulate macrophage signaling through interaction with NF-{kappa}B, a family of proinflammatory transcription factors.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c491 : 1
stoichiometry:c492 : 1
stoichiometry:c493 : 1
m211*m1965*0.1
nodelay
--
0
PMID: 17456803,15125834,15173580 ARRB1 and -2 interacted with the I{kappa}B{alpha} component of the NF-{kappa}B signaling complex in a range of cell types including HEK293, HeLa, Jurkat, COS-7 and THP-1 cells
p168
p168
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c498 : 1
stoichiometry:c497 : 1
stoichiometry:c500 : 1
stoichiometry:c499 : 1
m129*m175*0.1
nodelay
--
0
PMID: 17456803, 15173580 Overexpression of ARRB1 or -2 in HeLa cells inhibited TNF-induced NF-{kappa}B activation
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c494 : 1
stoichiometry:c495 : 1
stoichiometry:c496 : 1
m1966*m211*0.1
nodelay
--
0
PMID: 17456803,15125834,15173580 ARRB1 and -2 interacted with the I{kappa}B{alpha} component of the NF-{kappa}B signaling complex in a range of cell types including HEK293, HeLa, Jurkat, COS-7 and THP-1 cells
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c46 : 1
stoichiometry:c47 : 1
m27*m20*0.1
nodelay
--
0
PMID: 17456803 Class A receptors bind ARRB2 with much higher affinity than ARRB1, and Class B receptors bind both ARRBs with equal affinities.
p168
p170
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c501 : 1
stoichiometry:c502 : 1
stoichiometry:c504 : 1
stoichiometry:c503 : 1
m175*m129*0.1
nodelay
--
0
PMID: 17456803, 15173580 Overexpression of ARRB1 or -2 in HeLa cells inhibited TNF-induced NF-{kappa}B activation
p171
p171
cso30:i:ME_DNABinding
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c505 : 1
stoichiometry:c506 : 1
stoichiometry:c508 : 1
stoichiometry:c507 : 1
m214*m215*0.1
nodelay
--
0
PMID: 17456803,15125834 Similarly, overexpression of ARRB2 in HEK293 cells inhibited TNF-induced NF-{kappa}B DNA binding, while RNA interference-mediated knockdown of ARRB2 had an opposing effect
p172
p172
cso30:i:ME_Ubiquitination
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c509 : 1
stoichiometry:c511 : 1
stoichiometry:c527 : 1
stoichiometry:c536 : 1
stoichiometry:c510 : 1
m218*m225*0.1
nodelay
--
0
PMID: 17456803,11057907,10215628 In response to TLR or IL-1 family ligands, TNF receptor-associated factor (TRAF)6 is auto-ubiquitinated, oligomerizes and subsequently initiates downstream signaling events, including activation of IKK and JNK PMID: 17456803,16378096 ARRB1 and -2 interacted with TRAF6 upon TLR4 or IL-1R activation and prevented TRAF6 auto-ubiquitination, oligomerization and IKK activation
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c512 : 1
stoichiometry:c513 : 1
m220*0.1
nodelay
--
0
PMID: 17456803,11057907,10215628 In response to TLR or IL-1 family ligands, TNF receptor-associated factor (TRAF)6 is auto-ubiquitinated, oligomerizes and subsequently initiates downstream signaling events, including activation of IKK and JNK
p174
p174
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c514 : 1
stoichiometry:c515 : 1
stoichiometry:c516 : 1
m221*m217*0.1
nodelay
--
0
PMID: 17456803,11057907,10215628 In response to TLR or IL-1 family ligands, TNF receptor-associated factor (TRAF)6 is auto-ubiquitinated, oligomerizes and subsequently initiates downstream signaling events, including activation of IKK and JNK
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c517 : 1
stoichiometry:c519 : 1
stoichiometry:c518 : 1
m218*m226*0.1
nodelay
--
0
PMID: 17456803,11057907,10215628 In response to TLR or IL-1 family ligands, TNF receptor-associated factor (TRAF)6 is auto-ubiquitinated, oligomerizes and subsequently initiates downstream signaling events, including activation of IKK and JNK
p174
p176
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c520 : 1
stoichiometry:c521 : 1
stoichiometry:c522 : 1
m221*m224*0.1
nodelay
--
0
PMID: 17456803,11057907,10215628 In response to TLR or IL-1 family ligands, TNF receptor-associated factor (TRAF)6 is auto-ubiquitinated, oligomerizes and subsequently initiates downstream signaling events, including activation of IKK and JNK
p177
p177
cso30:i:ME_Binding
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c523 : 1
stoichiometry:c524 : 1
stoichiometry:c525 : 1
stoichiometry:c526 : 1
m218*m226*m1965*0.1
nodelay
--
0
PMID: 17456803,16378096 ARRB1 and -2 interacted with TRAF6 upon TLR4 or IL-1R activation and prevented TRAF6 auto-ubiquitination, oligomerization and IKK activation
p177
p178
cso30:i:ME_Binding
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c528 : 1
stoichiometry:c529 : 1
stoichiometry:c530 : 1
stoichiometry:c531 : 1
m225*m1965*m218*0.1
nodelay
--
0
PMID: 17456803,16378096 ARRB1 and -2 interacted with TRAF6 upon TLR4 or IL-1R activation and prevented TRAF6 auto-ubiquitination, oligomerization and IKK activation
p177
p179
cso30:i:ME_Binding
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c532 : 1
stoichiometry:c533 : 1
stoichiometry:c534 : 1
stoichiometry:c535 : 1
m218*m226*m1966*0.1
nodelay
--
0
PMID: 17456803,16378096 ARRB1 and -2 interacted with TRAF6 upon TLR4 or IL-1R activation and prevented TRAF6 auto-ubiquitination, oligomerization and IKK activation
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c48 : 1
stoichiometry:c49 : 1
stoichiometry:c50 : 1
m27*m21*0.1
nodelay
--
0
PMID: 17456803 Class A receptors bind ARRB2 with much higher affinity than ARRB1, and Class B receptors bind both ARRBs with equal affinities.
p177
p180
cso30:i:ME_Binding
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c537 : 1
stoichiometry:c538 : 1
stoichiometry:c539 : 1
stoichiometry:c540 : 1
m218*m225*m1966*0.1
nodelay
--
0
PMID: 17456803,16378096 ARRB1 and -2 interacted with TRAF6 upon TLR4 or IL-1R activation and prevented TRAF6 auto-ubiquitination, oligomerization and IKK activation
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c52 : 1
stoichiometry:c53 : 1
m18*m20*0.1
nodelay
--
0
PMID: 17456803 Class A receptors bind ARRB2 with much higher affinity than ARRB1, and Class B receptors bind both ARRBs with equal affinities.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1
m249*m6*0.1
nodelay
--
0
PMID: 17456803 Figure 1
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c55 : 1
stoichiometry:c56 : 1
m28*0.1
nodelay
--
0
PMID: 17456803 The classes are distinguished further on the basis of their association with ARRB during receptor internalization; ARRBs dissociate from Class A receptors prior to internalization, and ARRBs remain associated with Class B receptors throughout receptor internalization
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c57 : 1
stoichiometry:c58 : 1
stoichiometry:c59 : 1
m31*0.1
nodelay
--
0
PMID: 17456803 The classes are distinguished further on the basis of their association with ARRB during receptor internalization; ARRBs dissociate from Class A receptors prior to internalization, and ARRBs remain associated with Class B receptors throughout receptor internalization
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c61 : 1
m18*0.1
nodelay
--
0
PMID: 17456803 The classes are distinguished further on the basis of their association with ARRB during receptor internalization; ARRBs dissociate from Class A receptors prior to internalization, and ARRBs remain associated with Class B receptors throughout receptor internalization PMID: 17456803 Figure 1
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1
stoichiometry:c63 : 1
m30*0.1
nodelay
--
0
PMID: 17456803 The classes are distinguished further on the basis of their association with ARRB during receptor internalization; ARRBs dissociate from Class A receptors prior to internalization, and ARRBs remain associated with Class B receptors throughout receptor internalization PMID: 17456803 Figure 1
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c64 : 1
stoichiometry:c65 : 1
m29*0.1
nodelay
--
0
PMID: 17456803 The classes are distinguished further on the basis of their association with ARRB during receptor internalization; ARRBs dissociate from Class A receptors prior to internalization, and ARRBs remain associated with Class B receptors throughout receptor internalization PMID: 17456803 Figure 1
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c66 : 1
stoichiometry:c67 : 1
stoichiometry:c68 : 1
m12280*m6571*0.1
nodelay
--
0
PMID: 17456803,8011297 The complement component C5a acts as a potent neutrophil and monocyte chemoattractant via the GPCR C5aR/CD88
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c70 : 1
stoichiometry:c71 : 1
m12280*m36*0.1
nodelay
--
0
PMID: 17456803,8011297 The complement component C5a acts as a potent neutrophil and monocyte chemoattractant via the GPCR C5aR/CD88
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c73 : 1
m35*0.1
nodelay
--
0
PMID: 17456803,12176911 It also up-regulates the expression of other complement receptors such as CR1 and CR3 on leukocytes, thus enhancing phagocytic capacity and the respiratory burst
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c75 : 1
m35*0.1
nodelay
--
0
PMID: 17456803,12176911 It also up-regulates the expression of other complement receptors such as CR1 and CR3 on leukocytes, thus enhancing phagocytic capacity and the respiratory burst
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c77 : 1
m35*0.1
nodelay
--
0
PMID: 17456803,6300969,1690130,6809882 Further, C5a triggered the production of superoxide anion and PGE2 from resident and elicited mouse peritoneal macrophages, as well as TNF and IL-1 from human and mouse macrophage populations
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1
m13*m12*0.1
nodelay
--
0
PMID: 17456803 Agonist occupation of GPCRs stimulates a change in conformation of the receptor, which couples the receptor to the G-protein and promotes the exchange of GDP for GTP on the {alpha}-subunit.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c78 : 1
stoichiometry:c79 : 1
m35*0.1
nodelay
--
0
PMID: 17456803,6300969,1690130,6809882 Further, C5a triggered the production of superoxide anion and PGE2 from resident and elicited mouse peritoneal macrophages, as well as TNF and IL-1 from human and mouse macrophage populations
p31
p31
cso30:i:ME_Translation
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c80 : 1
stoichiometry:c82 : 1
stoichiometry:c81 : 1
m35*m40*0.1
nodelay
--
0
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c84 : 1
m41*0.1
nodelay
--
0
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c85 : 1
stoichiometry:c86 : 1
stoichiometry:c87 : 1
m43*m42*0.1
nodelay
--
0
PMID: 17456803 FPR1 triggers cellular locomotion upon recognition of N-formylated methionine from bacterial proteins.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c88 : 1
stoichiometry:c89 : 1
stoichiometry:c90 : 1
m45*m42*0.1
nodelay
--
0
PMID: 17456803,16684671,2161213,8198572 The classic FPR1 agonist, fMLP, has a much higher affinity for FPR1 than FPRL1, and ectopic expression studies suggest that FPRL2 does not recognize this ligand
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c91 : 1
stoichiometry:c92 : 1
stoichiometry:c93 : 1
m38196*m45*0.1
nodelay
--
0
PMID: 17456803,16684671,2161213,8198572 The classic FPR1 agonist, fMLP, has a much higher affinity for FPR1 than FPRL1, and ectopic expression studies suggest that FPRL2 does not recognize this ligand
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c94 : 1
stoichiometry:c95 : 1
stoichiometry:c96 : 1
m48*m12225*0.1
nodelay
--
0
PMID: 17456803,15623572,11602630,15187149,9892621,11160457 However, an endogenous peptide ligand for FPRL2 was identified recently , and it is now clear that FPR1 and FPRL1 can also detect nonformylated bacterial proteins , as well as endogenous ligands such as annexin 1 , serum amyloid A , and amyloid beta-peptide of 42 residues
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c97 : 1
stoichiometry:c98 : 1
stoichiometry:c99 : 1
m42*m63*0.1
nodelay
--
0
PMID: 17456803,15623572,11602630,15187149,9892621,11160457 However, an endogenous peptide ligand for FPRL2 was identified recently , and it is now clear that FPR1 and FPRL1 can also detect nonformylated bacterial proteins , as well as endogenous ligands such as annexin 1 , serum amyloid A , and amyloid beta-peptide of 42 residues
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c100 : 1
stoichiometry:c101 : 1
stoichiometry:c102 : 1
m63*m38196*0.1
nodelay
--
0
PMID: 17456803,15623572,11602630,15187149,9892621,11160457 However, an endogenous peptide ligand for FPRL2 was identified recently , and it is now clear that FPR1 and FPRL1 can also detect nonformylated bacterial proteins , as well as endogenous ligands such as annexin 1 , serum amyloid A , and amyloid beta-peptide of 42 residues
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c103 : 1
stoichiometry:c104 : 1
stoichiometry:c105 : 1
m66*m42*0.1
nodelay
--
0
PMID: 17456803,15623572,11602630,15187149,9892621,11160457 However, an endogenous peptide ligand for FPRL2 was identified recently , and it is now clear that FPR1 and FPRL1 can also detect nonformylated bacterial proteins , as well as endogenous ligands such as annexin 1 , serum amyloid A , and amyloid beta-peptide of 42 residues
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
m14*0.1
nodelay
--
0
PMID: 17456803 Agonist occupation of GPCRs stimulates a change in conformation of the receptor, which couples the receptor to the G-protein and promotes the exchange of GDP for GTP on the {alpha}-subunit.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c107 : 1
stoichiometry:c108 : 1
m38196*m66*0.1
nodelay
--
0
PMID: 17456803,15623572,11602630,15187149,9892621,11160457 However, an endogenous peptide ligand for FPRL2 was identified recently , and it is now clear that FPR1 and FPRL1 can also detect nonformylated bacterial proteins , as well as endogenous ligands such as annexin 1 , serum amyloid A , and amyloid beta-peptide of 42 residues
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c109 : 1
stoichiometry:c110 : 1
stoichiometry:c111 : 1
m42*m69*0.1
nodelay
--
0
PMID: 17456803,15623572,11602630,15187149,9892621,11160457 However, an endogenous peptide ligand for FPRL2 was identified recently , and it is now clear that FPR1 and FPRL1 can also detect nonformylated bacterial proteins , as well as endogenous ligands such as annexin 1 , serum amyloid A , and amyloid beta-peptide of 42 residues
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c112 : 1
stoichiometry:c113 : 1
stoichiometry:c114 : 1
m69*m38196*0.1
nodelay
--
0
PMID: 17456803,15623572,11602630,15187149,9892621,11160457 However, an endogenous peptide ligand for FPRL2 was identified recently , and it is now clear that FPR1 and FPRL1 can also detect nonformylated bacterial proteins , as well as endogenous ligands such as annexin 1 , serum amyloid A , and amyloid beta-peptide of 42 residues
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c115 : 1
stoichiometry:c116 : 1
stoichiometry:c117 : 1
m72*m42*0.1
nodelay
--
0
PMID: 17456803,15623572,11602630,15187149,9892621,11160457 However, an endogenous peptide ligand for FPRL2 was identified recently , and it is now clear that FPR1 and FPRL1 can also detect nonformylated bacterial proteins , as well as endogenous ligands such as annexin 1 , serum amyloid A , and amyloid beta-peptide of 42 residues
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c118 : 1
stoichiometry:c119 : 1
stoichiometry:c120 : 1
m72*m38196*0.1
nodelay
--
0
PMID: 17456803,15623572,11602630,15187149,9892621,11160457 However, an endogenous peptide ligand for FPRL2 was identified recently , and it is now clear that FPR1 and FPRL1 can also detect nonformylated bacterial proteins , as well as endogenous ligands such as annexin 1 , serum amyloid A , and amyloid beta-peptide of 42 residues
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c121 : 1
stoichiometry:c122 : 1
m46*0.1
nodelay
--
0
PMID: 17456803,11818447 FPRs also regulate the process of macrophage activation; fMLP induced the expression of inducible NO synthetase (iNOS) and production of NO in mouse peritoneal macrophages and the secretion of IL-1{alpha}, IL-1beta, and IL-6 in human PBMC
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c123 : 1
stoichiometry:c124 : 1
m93479*0.1
nodelay
--
0
PMID: 17456803,11818447 FPRs also regulate the process of macrophage activation; fMLP induced the expression of inducible NO synthetase (iNOS) and production of NO in mouse peritoneal macrophages and the secretion of IL-1{alpha}, IL-1beta, and IL-6 in human PBMC
p47
p47
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c125 : 1
stoichiometry:c126 : 1
stoichiometry:c127 : 1
m47*m2134*0.1
nodelay
--
0
PMID: 17456803,10872839,10611407 Activation of FPR or FPRL1 by fMLP in human monocytes/macrophages rapidly induced serine phosphorylation and heterologous desensitization of CCR5 and CXCR4
p47
p48
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c128 : 1
stoichiometry:c129 : 1
stoichiometry:c130 : 1
m46*m2134*0.1
nodelay
--
0
PMID: 17456803,10872839,10611407 Activation of FPR or FPRL1 by fMLP in human monocytes/macrophages rapidly induced serine phosphorylation and heterologous desensitization of CCR5 and CXCR4
p47
p49
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c131 : 1
stoichiometry:c132 : 1
stoichiometry:c133 : 1
m46*m2033*0.1
nodelay
--
0
PMID: 17456803,10872839,10611407 Activation of FPR or FPRL1 by fMLP in human monocytes/macrophages rapidly induced serine phosphorylation and heterologous desensitization of CCR5 and CXCR4
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c12 : 1
stoichiometry:c13 : 1
stoichiometry:c14 : 1
m15*0.1
nodelay
--
0
PMID: 17456803 The GTP-bound {alpha}-subunit dissociates from the beta{gamma}-subunit; the free subunits then regulate effector enzymes positively or negatively, ultimately leading to a biological response.
p47
p50
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c134 : 1
stoichiometry:c135 : 1
stoichiometry:c136 : 1
m47*m2033*0.1
nodelay
--
0
PMID: 17456803,10872839,10611407 Activation of FPR or FPRL1 by fMLP in human monocytes/macrophages rapidly induced serine phosphorylation and heterologous desensitization of CCR5 and CXCR4
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c137 : 1
stoichiometry:c138 : 1
m78*0.1
nodelay
--
0
PMID: 17456803 The PARs are a family of GPCRs that are activated upon proteolytic cleavage of their amino terminal exodomain.
p52
p52
cso30:i:ME_Cleavage
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c139 : 1
stoichiometry:c140 : 1
stoichiometry:c141 : 1
m1909*m1420*0.1
nodelay
--
0
PMID: 17456803,12805069,16000389 Thrombin-induced activation of PAR-1 and -2 in human peripheral monocytes or macrophages induced the release of the proinflammatory mediators MCP-1 (CCL2) and IL-6, while stimulation of PAR-2 by PAR-2 receptor-activating peptides in human peripheral blood monocytes increased the production of IL-1beta, IL-6, and IL-8
p46
p53
cso30:i:ME_Translation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c142 : 1
stoichiometry:c144 : 1
stoichiometry:c143 : 1
m93364*m46*0.1
nodelay
--
0
PMID: 17456803,11818447 FPRs also regulate the process of macrophage activation; fMLP induced the expression of inducible NO synthetase (iNOS) and production of NO in mouse peritoneal macrophages and the secretion of IL-1{alpha}, IL-1beta, and IL-6 in human PBMC
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c145 : 1
stoichiometry:c147 : 1
stoichiometry:c146 : 1
m80*m46*0.1
nodelay
--
0
PMID: 17456803,11818447 FPRs also regulate the process of macrophage activation; fMLP induced the expression of inducible NO synthetase (iNOS) and production of NO in mouse peritoneal macrophages and the secretion of IL-1{alpha}, IL-1beta, and IL-6 in human PBMC
p46
p55
cso30:i:ME_Translation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c148 : 1
stoichiometry:c150 : 1
stoichiometry:c149 : 1
m93248*m46*0.1
nodelay
--
0
PMID: 17456803,11818447 FPRs also regulate the process of macrophage activation; fMLP induced the expression of inducible NO synthetase (iNOS) and production of NO in mouse peritoneal macrophages and the secretion of IL-1{alpha}, IL-1beta, and IL-6 in human PBMC
p52
p56
cso30:i:ME_Cleavage
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c151 : 1
stoichiometry:c152 : 1
stoichiometry:c153 : 1
m1909*m1920*0.1
nodelay
--
0
PMID: 17456803,12805069,16000389 Thrombin-induced activation of PAR-1 and -2 in human peripheral monocytes or macrophages induced the release of the proinflammatory mediators MCP-1 (CCL2) and IL-6, while stimulation of PAR-2 by PAR-2 receptor-activating peptides in human peripheral blood monocytes increased the production of IL-1beta, IL-6, and IL-8
p57
p57
cso30:i:ME_Translation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c154 : 1
stoichiometry:c156 : 1
stoichiometry:c155 : 1
m93248*m3055*0.1
nodelay
--
0
PMID: 17456803, 12805069, 16000389 Thrombin-induced activation of PAR-1 and -2 in human peripheral monocytes or macrophages induced the release of the proinflammatory mediators MCP-1 (CCL2) and IL-6, while stimulation of PAR-2 by PAR-2 receptor-activating peptides in human peripheral blood monocytes increased the production of IL-1beta, IL-6, and IL-8
p57
p58
cso30:i:ME_Translation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c157 : 1
stoichiometry:c159 : 1
stoichiometry:c158 : 1
m2226*m93248*0.1
nodelay
--
0
PMID: 17456803, 12805069, 16000389 Thrombin-induced activation of PAR-1 and -2 in human peripheral monocytes or macrophages induced the release of the proinflammatory mediators MCP-1 (CCL2) and IL-6, while stimulation of PAR-2 by PAR-2 receptor-activating peptides in human peripheral blood monocytes increased the production of IL-1beta, IL-6, and IL-8
p59
p59
cso30:i:ME_Translation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c160 : 1
stoichiometry:c162 : 1
stoichiometry:c161 : 1
m93710*m3055*0.1
nodelay
--
0
PMID: 17456803, 12805069, 16000389 Thrombin-induced activation of PAR-1 and -2 in human peripheral monocytes or macrophages induced the release of the proinflammatory mediators MCP-1 (CCL2) and IL-6, while stimulation of PAR-2 by PAR-2 receptor-activating peptides in human peripheral blood monocytes increased the production of IL-1beta, IL-6, and IL-8
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c17 : 1
stoichiometry:c16 : 1
m16*m1961*0.1
nodelay
--
0
PMID: 17456803,2836733,7876239,10090766 Desensitization is initiated by phosphorylation of activated GPCRs within the third intracellular loop or the carboxyl-terminal tail by GRKs and/or second messenger-dependent protein kinases
p59
p60
cso30:i:ME_Translation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c163 : 1
stoichiometry:c165 : 1
stoichiometry:c164 : 1
m2226*m93710*0.1
nodelay
--
0
PMID: 17456803, 12805069, 16000389 Thrombin-induced activation of PAR-1 and -2 in human peripheral monocytes or macrophages induced the release of the proinflammatory mediators MCP-1 (CCL2) and IL-6, while stimulation of PAR-2 by PAR-2 receptor-activating peptides in human peripheral blood monocytes increased the production of IL-1beta, IL-6, and IL-8
p61
p61
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c166 : 1
stoichiometry:c168 : 1
stoichiometry:c167 : 1
m1920*m81*0.1
nodelay
--
0
PMID: 17456803, 12805069, 16000389 Thrombin-induced activation of PAR-1 and -2 in human peripheral monocytes or macrophages induced the release of the proinflammatory mediators MCP-1 (CCL2) and IL-6, while stimulation of PAR-2 by PAR-2 receptor-activating peptides in human peripheral blood monocytes increased the production of IL-1beta, IL-6, and IL-8
p59
p62
cso30:i:ME_Translation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c169 : 1
stoichiometry:c170 : 1
stoichiometry:c171 : 1
m2226*m93364*0.1
nodelay
--
0
PMID: 17456803, 12805069, 16000389 Thrombin-induced activation of PAR-1 and -2 in human peripheral monocytes or macrophages induced the release of the proinflammatory mediators MCP-1 (CCL2) and IL-6, while stimulation of PAR-2 by PAR-2 receptor-activating peptides in human peripheral blood monocytes increased the production of IL-1beta, IL-6, and IL-8
p59
p63
cso30:i:ME_Translation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c172 : 1
stoichiometry:c174 : 1
stoichiometry:c173 : 1
m93248*m2226*0.1
nodelay
--
0
PMID: 17456803, 12805069, 16000389 Thrombin-induced activation of PAR-1 and -2 in human peripheral monocytes or macrophages induced the release of the proinflammatory mediators MCP-1 (CCL2) and IL-6, while stimulation of PAR-2 by PAR-2 receptor-activating peptides in human peripheral blood monocytes increased the production of IL-1beta, IL-6, and IL-8
p59
p64
cso30:i:ME_Translation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c175 : 1
stoichiometry:c177 : 1
stoichiometry:c176 : 1
m82*m2226*0.1
nodelay
--
0
PMID: 17456803, 12805069, 16000389 Thrombin-induced activation of PAR-1 and -2 in human peripheral monocytes or macrophages induced the release of the proinflammatory mediators MCP-1 (CCL2) and IL-6, while stimulation of PAR-2 by PAR-2 receptor-activating peptides in human peripheral blood monocytes increased the production of IL-1beta, IL-6, and IL-8
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c178 : 1
stoichiometry:c179 : 1
stoichiometry:c180 : 1
m84*m83*0.1
nodelay
--
0
PMID: 17456803,1380279,9548509 Rodent and human macrophages express the neurokinin-1 receptor (NK-1R or TACR1), which signals in response to neuropeptide substance P (SP)
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c181 : 1
stoichiometry:c182 : 1
stoichiometry:c183 : 1
m85*m41*0.1
nodelay
--
0
PMID: 17456803,8982105,2457950,7573817 SP induced the protein expression of IL-1, TNF, and IL-6 in human blood monocytes and human monocyte-derived macrophages and increased production of reactive oxygen species and PGD2 secretion from guinea pig alveolar macrophages
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c184 : 1
stoichiometry:c185 : 1
stoichiometry:c186 : 1
m40*m85*0.1
nodelay
--
0
PMID: 17456803,8982105,2457950,7573817 SP induced the protein expression of IL-1, TNF, and IL-6 in human blood monocytes and human monocyte-derived macrophages and increased production of reactive oxygen species and PGD2 secretion from guinea pig alveolar macrophages
p66
p68
cso30:i:ME_Translation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c187 : 1
stoichiometry:c188 : 1
stoichiometry:c189 : 1
m85*m93248*0.1
nodelay
--
0
PMID: 17456803,8982105,2457950,7573817 SP induced the protein expression of IL-1, TNF, and IL-6 in human blood monocytes and human monocyte-derived macrophages and increased production of reactive oxygen species and PGD2 secretion from guinea pig alveolar macrophages
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c190 : 1
stoichiometry:c191 : 1
m85*0.1
nodelay
--
0
PMID: 17456803,8982105,2457950,7573817 SP induced the protein expression of IL-1, TNF, and IL-6 in human blood monocytes and human monocyte-derived macrophages and increased production of reactive oxygen species and PGD2 secretion from guinea pig alveolar macrophages
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c18 : 1
stoichiometry:c20 : 1
stoichiometry:c19 : 1
m16*m19*0.1
nodelay
--
0
PMID: 17456803,2836733,7876239,10090766 Desensitization is initiated by phosphorylation of activated GPCRs within the third intracellular loop or the carboxyl-terminal tail by GRKs and/or second messenger-dependent protein kinases
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c192 : 1
stoichiometry:c193 : 1
m85*0.1
nodelay
--
0
PMID: 17456803,8982105,2457950,7573817 SP induced the protein expression of IL-1, TNF, and IL-6 in human blood monocytes and human monocyte-derived macrophages and increased production of reactive oxygen species and PGD2 secretion from guinea pig alveolar macrophages
p71
p71
cso30:i:ME_Translation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c194 : 1
stoichiometry:c195 : 1
stoichiometry:c196 : 1
m155666*m93961*0.1
nodelay
--
0
PMID: 17456803,1380279,9548509,10573219 Expression of NK-1R and SP protein was induced in rat and human macrophages in response to LPS , suggesting the existence of an autocrine pathway
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c197 : 1
stoichiometry:c198 : 1
stoichiometry:c199 : 1
m155666*m88*0.1
nodelay
--
0
PMID: 17456803,1380279,9548509,10573219 Expression of NK-1R and SP protein was induced in rat and human macrophages in response to LPS , suggesting the existence of an autocrine pathway
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c200 : 1
stoichiometry:c201 : 1
m89*0.1
nodelay
--
0
PMID: 17456803,9761426 In vitro stimulation of murine peritoneal macrophages with ET-1 induced cyclooxygenase 2 (COX-2) mRNA expression and PGE2 production
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c202 : 1
stoichiometry:c203 : 1
m89*0.1
nodelay
--
0
PMID: 17456803,9761426 In vitro stimulation of murine peritoneal macrophages with ET-1 induced cyclooxygenase 2 (COX-2) mRNA expression and PGE2 production
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c204 : 1
stoichiometry:c206 : 1
stoichiometry:c205 : 1
m89*m41*0.1
nodelay
--
0
PMID: 17456803,9201047 In human monocytes, ET-1 triggered TNF production, as well as other cytokines, including IL-8, GM-CSF, IL-1beta, and IL-6
p31
p76
cso30:i:ME_Translation
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c207 : 1
stoichiometry:c208 : 1
stoichiometry:c209 : 1
m89*m82*0.1
nodelay
--
0
PMID: 17456803,9201047 In human monocytes, ET-1 triggered TNF production, as well as other cytokines, including IL-8, GM-CSF, IL-1beta, and IL-6
p31
p77
cso30:i:ME_Translation
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c210 : 1
stoichiometry:c212 : 1
stoichiometry:c211 : 1
m93248*m89*0.1
nodelay
--
0
PMID: 17456803,9201047 In human monocytes, ET-1 triggered TNF production, as well as other cytokines, including IL-8, GM-CSF, IL-1beta, and IL-6
p31
p78
cso30:i:ME_Translation
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c213 : 1
stoichiometry:c214 : 1
stoichiometry:c215 : 1
m89*m93364*0.1
nodelay
--
0
PMID: 17456803,9201047 In human monocytes, ET-1 triggered TNF production, as well as other cytokines, including IL-8, GM-CSF, IL-1beta, and IL-6
p31
p79
cso30:i:ME_Translation
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c216 : 1
stoichiometry:c218 : 1
stoichiometry:c217 : 1
m92*m89*0.1
nodelay
--
0
PMID: 17456803,9201047 In human monocytes, ET-1 triggered TNF production, as well as other cytokines, including IL-8, GM-CSF, IL-1beta, and IL-6
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c21 : 1
stoichiometry:c22 : 1
m1965*0.1
nodelay
--
0
PMID: 17456803,11777907,10770944,15498833 This phosphorylation promotes translocation of the cytosolic adaptor arrestin proteins to the membrane, where they bind to the receptor and promote internalization through interaction with Beta2-adaptin and clathrin components of the endocytic machinery
p80
p80
cso30:i:ME_Translation
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c219 : 1
stoichiometry:c220 : 1
stoichiometry:c221 : 1
m93*m41*0.1
nodelay
--
0
PMID: 17456803,9444616 For example, ET-1 treatment of the macrophage cell line J774.2 increased TNF secretion via the ETAR
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c222 : 1
stoichiometry:c224 : 1
stoichiometry:c223 : 1
m95*m89*0.1
nodelay
--
0
PMID: 17456803,15059899 Finally, ET-1, as well as ET-2, elicited MMP-2 and -9 production from human monocyte-derived macrophages when cocultured with breast cancer cells
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c226 : 1
stoichiometry:c225 : 1
stoichiometry:c227 : 1
m95*m94*0.1
nodelay
--
0
PMID: 17456803,15059899 Finally, ET-1, as well as ET-2, elicited MMP-2 and -9 production from human monocyte-derived macrophages when cocultured with breast cancer cells
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c228 : 1
stoichiometry:c229 : 1
stoichiometry:c230 : 1
m89*m96*0.1
nodelay
--
0
PMID: 17456803,15059899 Finally, ET-1, as well as ET-2, elicited MMP-2 and -9 production from human monocyte-derived macrophages when cocultured with breast cancer cells
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c231 : 1
stoichiometry:c232 : 1
stoichiometry:c233 : 1
m94*m96*0.1
nodelay
--
0
PMID: 17456803,15059899 Finally, ET-1, as well as ET-2, elicited MMP-2 and -9 production from human monocyte-derived macrophages when cocultured with breast cancer cells
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c234 : 1
stoichiometry:c235 : 1
m89*0.1
nodelay
--
0
PMID: 17456803,8825394 ET-1 can also influence the production of superoxides by macrophages; ET-1 primed O2? production from rabbit alveolar macrophages
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c236 : 1
stoichiometry:c237 : 1
m89*0.1
nodelay
--
0
PMID: 17456803,8825394 ET-1 can also influence the production of superoxides by macrophages; ET-1 primed O2? production from rabbit alveolar macrophages
p87
p87
cso30:i:ME_GeneExpression
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c238 : 1
stoichiometry:c240 : 1
stoichiometry:c239 : 1
m155666*m99*0.1
nodelay
--
0
PMID: 17456803,10338485,10534342,7693362 PAF antagonists inhibited LPS-regulated iNOS mRNA expression and NO production in murine macrophages and rat Kupffer cells, implying an involvement of autocrine PAF in LPS responses
p88
p88
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c241 : 1
stoichiometry:c242 : 1
stoichiometry:c243 : 1
m100*m5783*0.1
nodelay
--
0
PMID: 17456803,15718414,12117933 Exogenous LTB4 activated the NADPH oxidase system in alveolar macrophages , as well as NO and TNF production and parasite killing in Trypanosoma cruzi-infected murine macrophages , as well as NO and TNF production and parasite killing in Trypanosoma cruzi-infected murine macrophages
p88
p89
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c244 : 1
stoichiometry:c245 : 1
stoichiometry:c246 : 1
m101*m5783*0.1
nodelay
--
0
PMID: 17456803,15718414,12117933 Exogenous LTB4 activated the NADPH oxidase system in alveolar macrophages , as well as NO and TNF production and parasite killing in Trypanosoma cruzi-infected murine macrophages , as well as NO and TNF production and parasite killing in Trypanosoma cruzi-infected murine macrophages
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c24 : 1
m1966*0.1
nodelay
--
0
PMID: 17456803,11777907,10770944,15498833 This phosphorylation promotes translocation of the cytosolic adaptor arrestin proteins to the membrane, where they bind to the receptor and promote internalization through interaction with Beta2-adaptin and clathrin components of the endocytic machinery
p90
p90
cso30:i:ME_Translation
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c247 : 1
stoichiometry:c248 : 1
stoichiometry:c249 : 1
m100*m41*0.1
nodelay
--
0
PMID: 17456803,15718414,12117933 Exogenous LTB4 activated the NADPH oxidase system in alveolar macrophages , as well as NO and TNF production and parasite killing in Trypanosoma cruzi-infected murine macrophages , as well as NO and TNF production and parasite killing in Trypanosoma cruzi-infected murine macrophages
p90
p91
cso30:i:ME_Translation
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c250 : 1
stoichiometry:c251 : 1
stoichiometry:c252 : 1
m101*m41*0.1
nodelay
--
0
PMID: 17456803,15718414,12117933 Exogenous LTB4 activated the NADPH oxidase system in alveolar macrophages , as well as NO and TNF production and parasite killing in Trypanosoma cruzi-infected murine macrophages , as well as NO and TNF production and parasite killing in Trypanosoma cruzi-infected murine macrophages
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c253 : 1
stoichiometry:c254 : 1
stoichiometry:c255 : 1
m93479*m100*0.1
nodelay
--
0
PMID: 17456803,15718414,12117933 Exogenous LTB4 activated the NADPH oxidase system in alveolar macrophages , as well as NO and TNF production and parasite killing in Trypanosoma cruzi-infected murine macrophages , as well as NO and TNF production and parasite killing in Trypanosoma cruzi-infected murine macrophages
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c256 : 1
stoichiometry:c258 : 1
stoichiometry:c257 : 1
m93479*m101*0.1
nodelay
--
0
PMID: 17456803,15718414,12117933 Exogenous LTB4 activated the NADPH oxidase system in alveolar macrophages , as well as NO and TNF production and parasite killing in Trypanosoma cruzi-infected murine macrophages , as well as NO and TNF production and parasite killing in Trypanosoma cruzi-infected murine macrophages
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c259 : 1
stoichiometry:c261 : 1
stoichiometry:c260 : 1
m103*0.1
nodelay
--
0
PMID: 17456803,7836930,11301049 In fact, the effects are selective; PGE2 inhibited the production of the Th1-promoting cytokine IL-12 but amplified IL-10 production from human and mouse macrophages respectively
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c262 : 1
stoichiometry:c264 : 1
stoichiometry:c263 : 1
m39*m104*0.1
nodelay
--
0
PMID: 17456803,7836930,11301049 In fact, the effects are selective; PGE2 inhibited the production of the Th1-promoting cytokine IL-12 but amplified IL-10 production from human and mouse macrophages respectively
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c265 : 1
stoichiometry:c267 : 1
stoichiometry:c266 : 1
m105*0.1
nodelay
--
0
PMID: 17456803,11160207 Similarly, Kuroda et al. showed that pretreatment of murine splenocytes with PGE2 suppressed the protein expression of the Th1-associated chemokine IFN-inducible protein-10 and enhanced production of macrophage-derived chemokine/CCL22, a ligand for the Th2 cell-expressed chemokine receptor CCR4.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c269 : 1
stoichiometry:c270 : 1
stoichiometry:c268 : 1
m106*m39*0.1
nodelay
--
0
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c271 : 1
stoichiometry:c272 : 1
stoichiometry:c273 : 1
m4465*m107*0.1
nodelay
--
0
PMID: 17456803,11160207 Similarly, Kuroda et al. showed that pretreatment of murine splenocytes with PGE2 suppressed the protein expression of the Th1-associated chemokine IFN-inducible protein-10 and enhanced production of macrophage-derived chemokine/CCL22, a ligand for the Th2 cell-expressed chemokine receptor CCR4.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c274 : 1
stoichiometry:c275 : 1
stoichiometry:c276 : 1
m38875*m111*0.1
nodelay
--
0
PMID: 17456803,12829604 In humans, EMR2 and CD97 were identified as receptors for cell surface chondroitin sulfate , suggesting that the ligand for EMR1 may be a proteoglycan.
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
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--
cso30:c:OutputProcess
threshold
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cso30:c:InputProcess
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cso30:c:OutputProcess
threshold
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cso30:c:OutputProcess
threshold
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cso30:c:InputProcess
threshold
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--
cso30:c:OutputProcess
threshold
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--
cso30:c:InputProcess
threshold
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--
cso30:c:OutputProcess
threshold
--
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--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
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cso30:c:OutputProcess
threshold
--
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cso30:c:InputAssociation
threshold
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cso30:c:InputAssociation
threshold
--
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cso30:c:OutputProcess
threshold
--
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cso30:c:InputAssociation
threshold
--
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cso30:c:InputProcess
threshold
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cso30:c:OutputProcess
threshold
--
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cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
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--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
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--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
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