Entity
--
e1
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane
--
--
--
csml-variable:Double
m1
0
infinite
0
--
--
e10
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytosol
--
--
--
csml-variable:Double
m10
0
infinite
0
--
csml-variable:Double
m11
0
infinite
0
--
LPS:LBP
--
e12
cso30:c:Complex
cso30:i:CC_Extracellular
--
csml-variable:Double
m12
0
infinite
0
--
csml-variable:Double
m13
0
infinite
0
--
CD14
--
e14
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
csml-variable:Double
m14
0
infinite
0
--
LPS:LBP:CD14:TLR4
--
e15
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m15
0
infinite
0
--
csml-variable:Double
m16
0
infinite
0
--
LPS:LBP:CD14:TLR4:MD2
--
e17
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m17
0
infinite
0
--
LPS:LBP:CD14:TLR4:MD2:MyD88
--
e18
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m18
0
infinite
0
--
csml-variable:Double
m19
0
infinite
0
--
--
e2
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m2
0
infinite
0
--
csml-variable:Double
m20
0
infinite
0
--
LPS:LBP:CD14:TLR4:MD2:MyD88:IRAK1
--
e21
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m21
0
infinite
0
--
csml-variable:Double
m22
0
infinite
0
--
LPS:LBP:TLR4:MD2:MyD88:IRAK1:IRAK4
--
e23
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m23
0
infinite
0
--
csml-variable:Double
m24
0
infinite
0
--
csml-variable:Double
m25
0
infinite
0
--
IRAK1{p}:TRAF6
--
e26
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m26
0
infinite
0
--
csml-variable:Double
m27
0
infinite
0
--
csml-variable:Double
m28
0
infinite
0
--
csml-variable:Double
m29
0
infinite
0
--
--
e3
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
--
csml-variable:Double
m3
0
infinite
0
--
TAK1{activated}
--
e30
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m30
0
infinite
0
--
csml-variable:Double
m31
0
infinite
0
--
ASK1{activated}
--
e32
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m32
0
infinite
0
--
csml-variable:Double
m33
0
infinite
0
--
MEKK3{activated}
--
e34
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m34
0
infinite
0
--
csml-variable:Double
m35
0
infinite
0
--
JNK{activated}
--
e36
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m36
0
infinite
0
--
IKK{activated}
--
e37
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m37
0
infinite
0
--
p38{activated}
--
e38
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m38
0
infinite
0
--
csml-variable:Double
m39
0
infinite
0
--
--
e4
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m4
0
infinite
0
--
csml-variable:Double
m40
0
infinite
0
--
csml-variable:Double
m41
0
infinite
0
--
csml-variable:Double
m42
0
infinite
0
--
csml-variable:Double
m43
0
infinite
0
--
csml-variable:Double
m44
0
infinite
0
--
csml-variable:Double
m45
0
infinite
0
--
csml-variable:Double
m46
0
infinite
0
--
TRAM
--
e47
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m47
0
infinite
0
--
IkappaB{degraded}
--
e48
cso30:c:EntityBiological
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m48
0
infinite
0
--
NADPH oxidase 4
--
e49
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
csml-variable:Double
m49
0
infinite
0
--
csml-variable:Double
m5
0
infinite
0
--
--
e50
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelopeLumen
--
--
--
csml-variable:Double
m50
0
infinite
0
--
--
e51
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearPore
--
--
--
csml-variable:Double
m51
0
infinite
0
--
--
e52
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearInnerMembrane
--
--
--
csml-variable:Double
m52
0
infinite
0
--
--
e53
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearLumen
--
--
--
csml-variable:Double
m53
0
infinite
0
--
--
e54
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearOuterMembrane
--
--
--
csml-variable:Double
m54
0
infinite
0
--
--
e55
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleus
--
--
--
csml-variable:Double
m55
0
infinite
0
--
--
e56
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleoplasm
--
--
--
csml-variable:Double
m56
0
infinite
0
--
--
e57
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearBody
--
--
--
csml-variable:Double
m57
0
infinite
0
--
--
e58
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleolus
--
--
--
csml-variable:Double
m58
0
infinite
0
--
--
e59
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelope
--
--
--
csml-variable:Double
m59
0
infinite
0
--
LPS:LBP:CD14
--
e6
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
csml-variable:Double
m6
0
infinite
0
--
--
e60
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Chromatin
--
--
--
csml-variable:Double
m60
0
infinite
0
--
--
e61
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearChromosome
--
--
--
csml-variable:Double
m61
0
infinite
0
--
--
e62
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearCentromere
--
--
--
csml-variable:Double
m62
0
infinite
0
--
csml-variable:Double
m63
0
infinite
0
--
NADPH oxidase 4:TLR4
--
e64
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m64
0
infinite
0
--
NADPH oxidase 4{activated}
--
e65
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m65
0
infinite
0
--
csml-variable:Double
m66
0
infinite
0
--
csml-variable:Double
m67
0
infinite
0
--
csml-variable:Double
m68
0
infinite
0
--
csml-variable:Double
m69
0
infinite
0
--
--
e7
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell
--
--
--
csml-variable:Double
m7
0
infinite
0
--
TIRAP
--
e71
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m71
0
infinite
0
--
TRIAP:TLR4
--
e72
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m72
0
infinite
0
--
csml-variable:Double
m73
0
infinite
0
--
csml-variable:Double
m74
0
infinite
0
--
TRIF
--
e75
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m75
0
infinite
0
--
TRAM:TRIF:TLR4
--
e76
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m76
0
infinite
0
--
csml-variable:Double
m77
0
infinite
0
--
csml-variable:Double
m78
0
infinite
0
--
csml-variable:Double
m79
0
infinite
0
--
--
e8
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell_WithoutCellWall_
--
--
--
csml-variable:Double
m8
0
infinite
0
--
csml-variable:Double
m80
0
infinite
0
--
CD11b/CD18
--
e81
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m81
0
infinite
0
--
LPS:LBP:CD11b/CD18
--
e82
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
csml-variable:Double
m82
0
infinite
0
--
MSR
--
e83
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m83
0
infinite
0
--
LPS:LBP:MSR
--
e84
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m84
0
infinite
0
--
LPS{degraded}
--
e85
cso30:c:EntityBiological
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m85
0
infinite
0
--
NOD-1/NOD-2
--
e86
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m86
0
infinite
0
--
LPS:LBP:NOD-1/NOD-2
--
e87
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m87
0
infinite
0
--
CAP37
--
e88
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
csml-variable:Double
m88
0
infinite
0
--
LPS:CAP37
--
e89
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
csml-variable:Double
m89
0
infinite
0
--
--
e9
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytoplasm
--
--
--
csml-variable:Double
m9
0
infinite
0
--
Heparin:ATIII:thrombin
--
e90
cso30:c:Complex
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m90
0
infinite
0
--
Heparin:ATIII:thrombin:LPS:LBP
--
e91
cso30:c:Complex
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m91
0
infinite
0
--
csml-variable:Double
m92
0
infinite
0
--
csml-variable:Double
m93
0
infinite
0
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c6 : 1
m5*m11*0.1
nodelay
--
0
PMID: 17405910 association of single LPS molecules with plasmaderived LPS-binding protein (LBP)
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c41 : 1
stoichiometry:c49 : 1
stoichiometry:c42 : 1
m35*m30*0.1
nodelay
--
0
PMID: 17405910 MAP3K family (T1, TAK1; M3, MEKK3; A1, ASK1) which, in turn, activate Jnk (J), IKK (I), and p38 (p).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c34 : 1
stoichiometry:c32 : 1
m29*m26*0.1
nodelay
--
0
PMID: 17405910 TRAF6, a RING domain-containing E3 ubiquitin ligase, activates mitogen-activated protein kinase kinase kinases (MAP3K), transforming growth factor beta (TGF-beta)-activating kinase 1 (TAK1), mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase (MEKK3, and apoptosis signal-regulating kinase 1 (ASK1).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c33 : 1
stoichiometry:c36 : 1
stoichiometry:c35 : 1
m31*m26*0.1
nodelay
--
0
PMID: 17405910 TRAF6, a RING domain-containing E3 ubiquitin ligase, activates mitogen-activated protein kinase kinase kinases (MAP3K), transforming growth factor beta (TGF-beta)-activating kinase 1 (TAK1), mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase (MEKK3, and apoptosis signal-regulating kinase 1 (ASK1).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c39 : 1
stoichiometry:c38 : 1
m33*m26*0.1
nodelay
--
0
PMID: 17405910 TRAF6, a RING domain-containing E3 ubiquitin ligase, activates mitogen-activated protein kinase kinase kinases (MAP3K), transforming growth factor beta (TGF-beta)-activating kinase 1 (TAK1), mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase (MEKK3, and apoptosis signal-regulating kinase 1 (ASK1).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c30 : 1
stoichiometry:c40 : 1
m30*m28*0.1
nodelay
--
0
PMID: 17405910 MAP3K family (T1, TAK1; M3, MEKK3; A1, ASK1) which, in turn, activate Jnk (J), IKK (I), and p38 (p).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c43 : 1
stoichiometry:c29 : 1
m27*m30*0.1
nodelay
--
0
PMID: 17405910 MAP3K family (T1, TAK1; M3, MEKK3; A1, ASK1) which, in turn, activate Jnk (J), IKK (I), and p38 (p).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c58 : 1
stoichiometry:c53 : 1
m43*m36*0.1
nodelay
--
0
PMID: 17405910 Subsequent activation of cJun N-terminal kinase (Jnk), I-kappaB kinase (IKK) complex (consisting of alpha, beta and gamma subunits), and p38, leads to phosphorylation of cJun, I-kappaB, and ATF2, respectively.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c139 : 1
stoichiometry:c55 : 1
m45*m38*0.1
nodelay
--
0
PMID: 17405910 Subsequent activation of cJun N-terminal kinase (Jnk), I-kappaB kinase (IKK) complex (consisting of alpha, beta and gamma subunits), and p38, leads to phosphorylation of cJun, I-kappaB, and ATF2, respectively.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c62 : 1
stoichiometry:c57 : 1
m42*m37*0.1
nodelay
--
0
PMID: 17405910 Subsequent activation of cJun N-terminal kinase (Jnk), I-kappaB kinase (IKK) complex (consisting of alpha, beta and gamma subunits), and p38, leads to phosphorylation of cJun, I-kappaB, and ATF2, respectively.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c60 : 1
m39*0.1
nodelay
--
0
PMID: 17405910 Phosphorylated I-kappaB is ubiquitinated and degraded by the 26S proteosome, leaving the p65-p50 dimer (NF-kappaB), which is now free to translocate to the nucleus.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c3 : 1
stoichiometry:c4 : 1
stoichiometry:c5 : 1
m12*m14*0.1
nodelay
--
0
PMID: 17405910 one LPS bound to one LBP, the so formed protein?glycolipid complex is recognized, with high specificity, by CD14
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c94 : 1
stoichiometry:c95 : 1
stoichiometry:c96 : 1
m40*0.1
nodelay
--
0
PMID: 17405910 Phosphorylated I-kappaB is ubiquitinated and degraded by the 26S proteosome, leaving the p65-p50 dimer (NF-kappaB), which is now free to translocate to the nucleus.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c68 : 1
m41*0.1
nodelay
--
0
PMID: 17405910 Phosphorylated I-kappaB is ubiquitinated and degraded by the 26S proteosome, leaving the p65-p50 dimer (NF-kappaB), which is now free to translocate to the nucleus.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c70 : 1
stoichiometry:c71 : 1
m49*m13*0.1
nodelay
--
0
PMID: 17405910, 15356101 The generation of ROS appears to result from a direct activation of membrane-bound NADPH oxidase 4 by TLR4.
p23
p23
cso30:i:ME_UnknownActivation
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c73 : 1
stoichiometry:c72 : 1
m64*0.1
nodelay
--
0
PMID: 17405910, 15356101 The generation of ROS appears to result from a direct activation of membrane-bound NADPH oxidase 4 by TLR4.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c75 : 1
stoichiometry:c141 : 1
stoichiometry:c76 : 1
m74*m72*0.1
nodelay
--
0
PMID: 17405910, 12062447, 12062447 TIRAP, another TLR4 adapter protein appears to be involved in the activation of interferon regulatory factor 3 (IRF3), a transcription factor, which induces the type I interferon gene, and further evidence suggests that this activation is mediated by a double-stranded RNA responsive protein kinase (PKR).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c78 : 1
stoichiometry:c79 : 1
m24*m68*0.1
nodelay
--
0
PMID: 17405910, 9564042 ASK1 can only be activated by TRAF6 if the associated thioredoxin (TrX) is displaced from TRAF6.
p26
p26
cso30:i:ME_Dissociation
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c80 : 1
stoichiometry:c83 : 1
stoichiometry:c81 : 1
stoichiometry:c82 : 1
m67*m69*0.1
nodelay
--
0
PMID: 17405910, 15864310 This dissociation depends on the formation of ROS.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c143 : 1
stoichiometry:c101 : 1
m77*m76*0.1
nodelay
--
0
PMID: 17405910, 12062447, 15029200, 16006187 TIR domain-containing adapter inducing interferon (TRIF) and TRIF-related adapter molecule (TRAM), both involved in the activation of IRF3 and IRF7.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c92 : 1
stoichiometry:c88 : 1
m78*0.1
nodelay
--
0
PMID: 17405910, 12062447, 12062447 TIRAP, another TLR4 adapter protein appears to be involved in the activation of interferon regulatory factor 3 (IRF3), a transcription factor, which induces the type I interferon gene, and further evidence suggests that this activation is mediated by a double-stranded RNA responsive protein kinase (PKR).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c89 : 1
stoichiometry:c90 : 1
stoichiometry:c91 : 1
m13*m71*0.1
nodelay
--
0
PMID: 17405910, 12062447, 12062447 TIRAP, another TLR4 adapter protein appears to be involved in the activation of interferon regulatory factor 3 (IRF3), a transcription factor, which induces the type I interferon gene, and further evidence suggests that this activation is mediated by a double-stranded RNA responsive protein kinase (PKR).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1
m6*m13*0.1
nodelay
--
0
PMID: 17405910, 11034352 activation of TLR4, which is thought to initiate intracellular signaling upon association with a CD14 molecule that is occupied by an LPS?LBP complex.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c63 : 1
stoichiometry:c64 : 1
stoichiometry:c65 : 1
m47*m75*m13*0.1
nodelay
--
0
PMID: 17405910 Apart from MyD88 and TIRAP, additional TLR4 adapter proteins have been identified.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c97 : 1
stoichiometry:c142 : 1
stoichiometry:c98 : 1
m77*m66*0.1
nodelay
--
0
PMID: 17405910, 12062447, 15029200, 16006187 TIRAP, another TLR4 adapter protein appears to be involved in the activation of interferon regulatory factor 3 (IRF3), a transcription factor, which induces the type I interferon gene, and further evidence suggests that this activation is mediated by a double-stranded RNA responsive protein kinase (PKR).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c105 : 1
stoichiometry:c100 : 1
m79*m76*0.1
nodelay
--
0
PMID: 17405910, 16006187 TIR domain-containing adapter inducing interferon (TRIF) and TRIF-related adapter molecule (TRAM), both involved in the activation of IRF3 and IRF7.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c103 : 1
stoichiometry:c104 : 1
stoichiometry:c106 : 1
m12*m81*0.1
nodelay
--
0
PMID: 17405910, 9820516 macrophages express several other LPS receptors, for example, CD11b/CD18
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c107 : 1
stoichiometry:c108 : 1
stoichiometry:c109 : 1
m12*m83*0.1
nodelay
--
0
PMID: 17405910, 1852209 macrophages express several other LPS receptors, for example, CD11b/CD18, class A macrophage scavenger receptor (MSR)
p35
p35
cso30:i:ME_UnknownDegradation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c110 : 1
stoichiometry:c111 : 1
stoichiometry:c85 : 1
stoichiometry:c86 : 1
m84*0.1
nodelay
--
0
PMID: 17405910, 1852209 MSR acts as a scavenger for LPS, that is, rather than eliciting a proinflammatory response, the MSR?LPS complex is internalized and LPS is partially degraded.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c112 : 1
stoichiometry:c113 : 1
stoichiometry:c114 : 1
m12*m86*0.1
nodelay
--
0
PMID: 17405910, 16021602 NOD-1 and -2 agonists also act in synergy with LPS to stimulate cytokine production.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c115 : 1
stoichiometry:c116 : 1
stoichiometry:c117 : 1
m5*m88*0.1
nodelay
--
0
PMID: 17405910, 15275964 Cationic proteins, e.g., protamines and CAP37, associate with LPS and bind to cellular surfaces.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c118 : 1
stoichiometry:c119 : 1
stoichiometry:c120 : 1
m90*m12*0.1
nodelay
--
0
PMID: 17405910 Heparin exerts its anticoagulant effect through binding to AT III and thrombin. Apart from its interaction with proteins of the coagulation pathway, heparin binds to LBP and displaces LPS
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c121 : 1
stoichiometry:c122 : 1
stoichiometry:c123 : 1
stoichiometry:c66 : 1
m12*m92*0.1
nodelay
--
0
PMID: 17405910, 14550561 LPS is bound and neutralized by poly-L-histidine.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1
m15*m16*0.1
nodelay
--
0
PMID: 17405910 TLR4 signaling depends on the presence of MD2, a secretory glycoprotein that associates with TLR4.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c125 : 1
stoichiometry:c127 : 1
stoichiometry:c126 : 1
m31*m24*0.1
nodelay
--
0
PMID: 17405910, 9564042 ASK1 can only be activated by TRAF6 if the associated thioredoxin (TrX) is displaced from TRAF6.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c84 : 1
stoichiometry:c128 : 1
m34*m27*0.1
nodelay
--
0
PMID: 17405910 MAP3K family (T1, TAK1; M3, MEKK3; A1, ASK1) which, in turn, activate Jnk (J), IKK (I), and p38 (p).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c129 : 1
stoichiometry:c130 : 1
m32*m27*0.1
nodelay
--
0
PMID: 17405910 MAP3K family (T1, TAK1; M3, MEKK3; A1, ASK1) which, in turn, activate Jnk (J), IKK (I), and p38 (p).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c131 : 1
stoichiometry:c132 : 1
m34*m28*0.1
nodelay
--
0
PMID: 17405910 MAP3K family (T1, TAK1; M3, MEKK3; A1, ASK1) which, in turn, activate Jnk (J), IKK (I), and p38 (p).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c48 : 1
stoichiometry:c133 : 1
stoichiometry:c134 : 1
m32*m28*0.1
nodelay
--
0
PMID: 17405910 MAP3K family (T1, TAK1; M3, MEKK3; A1, ASK1) which, in turn, activate Jnk (J), IKK (I), and p38 (p).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c135 : 1
stoichiometry:c136 : 1
m34*m35*0.1
nodelay
--
0
PMID: 17405910 MAP3K family (T1, TAK1; M3, MEKK3; A1, ASK1) which, in turn, activate Jnk (J), IKK (I), and p38 (p).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c137 : 1
stoichiometry:c138 : 1
m32*m35*0.1
nodelay
--
0
PMID: 17405910 MAP3K family (T1, TAK1; M3, MEKK3; A1, ASK1) which, in turn, activate Jnk (J), IKK (I), and p38 (p).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c140 : 1
m65*0.1
nodelay
--
0
PMID: 17405910, 15356101 The generation of ROS appears to result from a direct activation of membrane-bound NADPH oxidase 4 by TLR4.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1
m19*m17*0.1
nodelay
--
0
PMID: 17405910 Subsequent to the association of MyD88 with TLR4, MyD88 recruits the IL-1 receptor-associated kinase 1 (IRAK1).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1
m18*m20*0.1
nodelay
--
0
PMID: 17405910 Subsequent to the association of MyD88 with TLR4, MyD88 recruits the IL-1 receptor-associated kinase 1 (IRAK1).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1
stoichiometry:c124 : 1
m23*0.1
nodelay
--
0
PMID: 17405910 Phosphorylation of IRAK1 by IRAK4 and other kinases results in the dissociation of IRAK1 from TLR4.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1
m25*m24*0.1
nodelay
--
0
PMID: 17405910 Phosphorylated IRAK1 associates, in the cytosol, with tumor necrosis factor receptor (TNFR)-associated factor 6 (TRAF6).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1
m21*m22*0.1
nodelay
--
0
PMID: 17405910 Phosphorylation of IRAK1 by IRAK4 and other kinases results in the dissociation of IRAK1 from TLR4.
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--