_enti_e7
_enti_e8
_enti_e1
_enti_e9
_enti_e10
_enti_e3
_enti_e2
_enti_e4
_enti_e55
_enti_e6
_enti_e35
_enti_e59
_enti_e53
_enti_e11
_enti_e5
_enti_e40
_enti_e37
_enti_e52
_enti_e50
_enti_e51
_enti_e54
_enti_e56
_enti_e41
_enti_e39
_enti_e38
_enti_e36
_enti_e61
_enti_e57
_enti_e58
_enti_e33
_enti_e62
_enti_e60
_enti_e34
g2_fact_g2
g1_fact_g14
g1_fact_g1
g2_fact_g12
g2_fact_g13
g1_fact_g3
g3_fact_g4
g1_fact_g6
g2_fact_g5
p1_propro_p1
PMID: 17395579
TLR7 and -8 (when activated by ssRNA) and TLR9 (when activated by CpG-rich DNA) mediate MyD88-dependent adaptor signaling.
c4 cso30:c:InputProcess connector
c17 cso30:c:InputProcess connector
c5 cso30:c:OutputProcess connector
p2_propro_p2
PMID: 17395579
TLR7 and -8 (when activated by ssRNA) and TLR9 (when activated by CpG-rich DNA) mediate MyD88-dependent adaptor signaling.
c1 cso30:c:InputProcess connector
c6 cso30:c:InputProcess connector
c7 cso30:c:OutputProcess connector
p3_propro_p3
PMID: 17395579
TLR7 and -8 (when activated by ssRNA) and TLR9 (when activated by CpG-rich DNA) mediate MyD88-dependent adaptor signaling.
c8 cso30:c:InputProcess connector
c16 cso30:c:InputProcess connector
c9 cso30:c:OutputProcess connector
p4_propro_p4
PMID: 17395579
TLR7 and -8 (when activated by ssRNA) and TLR9 (when activated by CpG-rich DNA) mediate MyD88-dependent adaptor signaling.
c12 cso30:c:InputProcess connector
c18 cso30:c:InputProcess connector
c13 cso30:c:OutputProcess connector
p5_propro_p5
PMID: 17395579
TLR7 and -8 (when activated by ssRNA) and TLR9 (when activated by CpG-rich DNA) mediate MyD88-dependent adaptor signaling.
c2 cso30:c:InputProcess connector
c10 cso30:c:InputProcess connector
c11 cso30:c:OutputProcess connector
p6_propro_p6
PMID: 17395579
TLR7 and -8 (when activated by ssRNA) and TLR9 (when activated by CpG-rich DNA) mediate MyD88-dependent adaptor signaling.
c3 cso30:c:InputProcess connector
c14 cso30:c:InputProcess connector
c15 cso30:c:OutputProcess connector
p7_propro_p7
PMID: 17395579
TLR3 when activated by dsRNA mediates MyD88-independent signaling via the TRIF adaptor protein.
c19 cso30:c:InputProcess connector
c20 cso30:c:InputProcess connector
c21 cso30:c:OutputProcess connector
p8_propro_p8
PMID: 17395579
TLR3 when activated by dsRNA mediates MyD88-independent signaling via the TRIF adaptor protein.
c22 cso30:c:InputProcess connector
c23 cso30:c:InputProcess connector
c24 cso30:c:OutputProcess connector
p9_propro_p9
PMID: 17395579
The interaction of RNA with the RIG-I or MDA5 cytosolic cellular helicase mediates signaling via CARD domain interactions between the helicase sensor and a mitochondrial membrane-associated adaptor protein known variously as IPS-1, CARDIF, MAVS, and VISA.
c26 cso30:c:InputProcess connector
c29 cso30:c:InputProcess connector
c30 cso30:c:OutputProcess connector
p10_propro_p10
PMID: 17395579
The interaction of RNA with the RIG-I or MDA5 cytosolic cellular helicase mediates signaling via CARD domain interactions between the helicase sensor and a mitochondrial membrane-associated adaptor protein known variously as IPS-1, CARDIF, MAVS, and VISA.
c25 cso30:c:InputProcess connector
c27 cso30:c:InputProcess connector
c28 cso30:c:OutputProcess connector
p11_propro_p11
PMID: 17395579
The interaction of RNA with the RIG-I or MDA5 cytosolic cellular helicase mediates signaling via CARD domain interactions between the helicase sensor and a mitochondrial membrane-associated adaptor protein known variously as IPS-1, CARDIF, MAVS, and VISA.
c31 cso30:c:InputProcess connector
c32 cso30:c:InputProcess connector
c33 cso30:c:OutputProcess connector
p12_propro_p12
PMID: 17395579
The interaction of RNA with the RIG-I or MDA5 cytosolic cellular helicase mediates signaling via CARD domain interactions between the helicase sensor and a mitochondrial membrane-associated adaptor protein known variously as IPS-1, CARDIF, MAVS, and VISA.
c34 cso30:c:InputProcess connector
c35 cso30:c:InputProcess connector
c36 cso30:c:OutputProcess connector
p14_propro_p14
PMID: 17395579
The IPS-1, TRIF, and MyD88 adaptors then lead to IRF and NF-kappaB activation via IKK (inhibitor of nuclear factor-{kappa}B kinase), IRAK (interleukin 1 receptor-associated kinase), TBK (TANK-binding kinase), and TRAF (tumor necrosis factor receptor-associated factor) proteins.
c40 cso30:c:InputProcess connector
c42 cso30:c:InputAssociation connector
c41 cso30:c:OutputProcess connector
p15_propro_p15
PMID: 17395579
The IPS-1, TRIF, and MyD88 adaptors then lead to IRF and NF-kappaB activation via IKK (inhibitor of nuclear factor-{kappa}B kinase), IRAK (interleukin 1 receptor-associated kinase), TBK (TANK-binding kinase), and TRAF (tumor necrosis factor receptor-associated factor) proteins.
c43 cso30:c:InputProcess connector
c47 cso30:c:InputAssociation connector
c44 cso30:c:OutputProcess connector
p16_propro_p16
PMID: 17395579
The IPS-1, TRIF, and MyD88 adaptors then lead to IRF and NF-kappaB activation via IKK (inhibitor of nuclear factor-{kappa}B kinase), IRAK (interleukin 1 receptor-associated kinase), TBK (TANK-binding kinase), and TRAF (tumor necrosis factor receptor-associated factor) proteins.
c45 cso30:c:InputProcess connector
c48 cso30:c:InputAssociation connector
c46 cso30:c:OutputProcess connector
p17_propro_p17
PMID: 17395579
The IPS-1, TRIF, and MyD88 adaptors then lead to IRF and NF-kappaB activation via IKK (inhibitor of nuclear factor-{kappa}B kinase), IRAK (interleukin 1 receptor-associated kinase), TBK (TANK-binding kinase), and TRAF (tumor necrosis factor receptor-associated factor) proteins.
c49 cso30:c:InputAssociation connector
c50 cso30:c:InputProcess connector
c51 cso30:c:OutputProcess connector
p18_propro_p18
PMID: 17395579
The IPS-1, TRIF, and MyD88 adaptors then lead to IRF and NF-kappaB activation via IKK (inhibitor of nuclear factor-{kappa}B kinase), IRAK (interleukin 1 receptor-associated kinase), TBK (TANK-binding kinase), and TRAF (tumor necrosis factor receptor-associated factor) proteins.
c52 cso30:c:InputProcess connector
c54 cso30:c:InputAssociation connector
c53 cso30:c:OutputProcess connector
p19_propro_p19
PMID: 17395579
The IPS-1, TRIF, and MyD88 adaptors then lead to IRF and NF-kappaB activation via IKK (inhibitor of nuclear factor-{kappa}B kinase), IRAK (interleukin 1 receptor-associated kinase), TBK (TANK-binding kinase), and TRAF (tumor necrosis factor receptor-associated factor) proteins.
c55 cso30:c:InputProcess connector
c61 cso30:c:InputAssociation connector
c56 cso30:c:OutputProcess connector
p20_propro_p20
PMID: 17395579
The IPS-1, TRIF, and MyD88 adaptors then lead to IRF and NF-kappaB activation via IKK (inhibitor of nuclear factor-{kappa}B kinase), IRAK (interleukin 1 receptor-associated kinase), TBK (TANK-binding kinase), and TRAF (tumor necrosis factor receptor-associated factor) proteins.
c57 cso30:c:InputProcess connector
c62 cso30:c:InputAssociation connector
c58 cso30:c:OutputProcess connector
p21_propro_p21
PMID: 17395579
The IPS-1, TRIF, and MyD88 adaptors then lead to IRF and NF-kappaB activation via IKK (inhibitor of nuclear factor-{kappa}B kinase), IRAK (interleukin 1 receptor-associated kinase), TBK (TANK-binding kinase), and TRAF (tumor necrosis factor receptor-associated factor) proteins.
c59 cso30:c:InputProcess connector
c63 cso30:c:InputAssociation connector
c60 cso30:c:OutputProcess connector
p22_propro_p22
PMID: 17395579
The IPS-1, TRIF, and MyD88 adaptors then lead to IRF and NF-kappaB activation via IKK (inhibitor of nuclear factor-{kappa}B kinase), IRAK (interleukin 1 receptor-associated kinase), TBK (TANK-binding kinase), and TRAF (tumor necrosis factor receptor-associated factor) proteins.
c64 cso30:c:InputProcess connector
c66 cso30:c:InputAssociation connector
c65 cso30:c:OutputProcess connector
p23_propro_p23
PMID: 17395579
The IPS-1, TRIF, and MyD88 adaptors then lead to IRF and NF-kappaB activation via IKK (inhibitor of nuclear factor-{kappa}B kinase), IRAK (interleukin 1 receptor-associated kinase), TBK (TANK-binding kinase), and TRAF (tumor necrosis factor receptor-associated factor) proteins.
c67 cso30:c:InputProcess connector
c69 cso30:c:InputAssociation connector
c68 cso30:c:OutputProcess connector
p24_propro_p24
PMID: 17395579
The IPS-1, TRIF, and MyD88 adaptors then lead to IRF and NF-kappaB activation via IKK (inhibitor of nuclear factor-{kappa}B kinase), IRAK (interleukin 1 receptor-associated kinase), TBK (TANK-binding kinase), and TRAF (tumor necrosis factor receptor-associated factor) proteins.
c70 cso30:c:InputProcess connector
c71 cso30:c:InputProcess connector
c72 cso30:c:OutputProcess connector
p25_propro_p25
PMID: 17395579
Translocation into the nucleus of IRF dimers (IRF-3, IRF-7) and activated NF-kappaB lead to transcriptional activation of type I interferon gene expression (for example IFN-beta and IFN-alpha4).
c73 cso30:c:InputProcess connector
c74 cso30:c:OutputProcess connector
p26_propro_p26
PMID: 17395579
Translocation into the nucleus of IRF dimers (IRF-3, IRF-7) and activated NF-kappaB lead to transcriptional activation of type I interferon gene expression (for example IFN-beta and IFN-alpha4).
c75 cso30:c:InputAssociation connector
c76 cso30:c:OutputProcess connector
p13_propro_p13
PMID: 17395579
The IPS-1, TRIF, and MyD88 adaptors then lead to IRF and NF-kappaB activation via IKK (inhibitor of nuclear factor-{kappa}B kinase), IRAK (interleukin 1 receptor-associated kinase), TBK (TANK-binding kinase), and TRAF (tumor necrosis factor receptor-associated factor) proteins.
c37 cso30:c:InputProcess connector
c39 cso30:c:InputAssociation connector
c38 cso30:c:OutputProcess connector
p27_propro_p27
PMID: 17395579
The IPS-1, TRIF, and MyD88 adaptors then lead to IRF and NF-kappaB activation via IKK (inhibitor of nuclear factor-{kappa}B kinase), IRAK (interleukin 1 receptor-associated kinase), TBK (TANK-binding kinase), and TRAF (tumor necrosis factor receptor-associated factor) proteins.
c77 cso30:c:InputProcess connector
c82 cso30:c:InputAssociation connector
c78 cso30:c:OutputProcess connector
p28_propro_p28
PMID: 17395579
The IPS-1, TRIF, and MyD88 adaptors then lead to IRF and NF-kappaB activation via IKK (inhibitor of nuclear factor-{kappa}B kinase), IRAK (interleukin 1 receptor-associated kinase), TBK (TANK-binding kinase), and TRAF (tumor necrosis factor receptor-associated factor) proteins.
c79 cso30:c:InputProcess connector
c81 cso30:c:InputAssociation connector
c80 cso30:c:OutputProcess connector
p29_propro_p29
PMID: 17395579
Translocation into the nucleus of IRF dimers (IRF-3, IRF-7) and activated NF-kappaB lead to transcriptional activation of type I interferon gene expression (for example IFN-beta and IFN-alpha4).
c83 cso30:c:InputProcess connector
c84 cso30:c:OutputProcess connector
p30_propro_p30
PMID: 17395579
Translocation into the nucleus of IRF dimers (IRF-3, IRF-7) and activated NF-kappaB lead to transcriptional activation of type I interferon gene expression (for example IFN-beta and IFN-alpha4).
c86 cso30:c:InputAssociation connector
c88 cso30:c:OutputProcess connector
p31_propro_p31
PMID: 17395579
Translocation into the nucleus of IRF dimers (IRF-3, IRF-7) and activated NF-kappaB lead to transcriptional activation of type I interferon gene expression (for example IFN-beta and IFN-alpha4).
c85 cso30:c:InputAssociation connector
c89 cso30:c:OutputProcess connector
p32_propro_p32
PMID: 17395579
Translocation into the nucleus of IRF dimers (IRF-3, IRF-7) and activated NF-kappaB lead to transcriptional activation of type I interferon gene expression (for example IFN-beta and IFN-alpha4).
c87 cso30:c:InputAssociation connector
c90 cso30:c:OutputProcess connector
TLR7_enti_e12
TLR7
TLR8_enti_e13
TLR8
TLR9_enti_e14
TLR9
ssRNA: TLR7_enti_e15
ssRNA: TLR7
ssRNA: TLR8_enti_e16
ssRNA: TLR8
CpG DNA: TLR9_enti_e17
CpG DNA: TLR9
ssRNA: TLR7: MyD88_enti_e18
ssRNA: TLR7: MyD88
ssRNA: TLR8: MyD88_enti_e19
ssRNA: TLR8: MyD88
CpG DNA: TLR9: MyD88_enti_e20
CpG DNA: TLR9: MyD88
MyD88_enti_e21
MyD88
ssRNA_enti_e22
ssRNA
CpG DNA_enti_e23
CpG DNA
dsRNA_enti_e24
dsRNA
TLR3_enti_e25
TLR3
dsRNA: TLR3_enti_e26
dsRNA: TLR3
TRIF_enti_e27
TRIF
dsRNA: TLR3: TRIF_enti_e28
dsRNA: TLR3: TRIF
RIG-1_enti_e29
RIG-1
Mda-5_enti_e30
Mda-5
dsRNA: RIG-1_enti_e31
dsRNA: RIG-1
dsRNA: Mda-5_enti_e32
dsRNA: Mda-5
IPS-1_enti_e42
IPS-1
dsRNA: RIG-1: IPS-1_enti_e43
dsRNA: RIG-1: IPS-1
dsRNA: Mda-5: IPS-1_enti_e44
dsRNA: Mda-5: IPS-1
TRAF3_enti_e45
TRAF3
TRAF3{activated}_enti_e46
TRAF3{activated}
TBK-1: IKK-i_enti_e47
TBK-1: IKK-i
TBK-1: IKK-i{activated}_enti_e48
TBK-1: IKK-i{activated}
IRF-3_enti_e49
IRF-3
IRF-3{activated}_enti_e63
IRF-3{activated}
IRF-7_enti_e64
IRF-7
IRF-7{activated}_enti_e65
IRF-7{activated}
IKK-alpha: IKK-beta: IKK-gamma_enti_e66
IKK-alpha: IKK-beta: IKK-gamma
IKK-alpha: IKK-beta: IKK-gamma{activated}_enti_e67
IKK-alpha: IKK-beta: IKK-gamma{activated}
NF-kappaB_enti_e68
NF-kappaB
NF-kappaB{activated}_enti_e69
NF-kappaB{activated}
IRAK1: IRAK4_enti_e70
IRAK1: IRAK4
IRAK1: IRAK4{activated}_enti_e71
IRAK1: IRAK4{activated}
TRAF6_enti_e72
TRAF6
TRAF6{activated}_enti_e73
TRAF6{activated}
IRF-3: IRF-7 {activated}_enti_e74
IRF-3: IRF-7 {activated}
IRF-3: IRF-7 {nuclear}_enti_e75
IRF-3: IRF-7 {nuclear}
IFN-beta_enti_e76
IFN-beta
NF-kappaB{nucleus}_enti_e77
NF-kappaB{nucleus}
IFN-alpha4_enti_e78
IFN-alpha4