Entity
--
e1
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane
--
--
--
csml-variable:Double
m1
0
infinite
0
--
--
e10
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytosol
--
--
--
csml-variable:Double
m10
0
infinite
0
--
--
e11
cso30:c:EntityBiologicalCompartment
cso30:i:CC_EndosomeLumen
--
--
--
csml-variable:Double
m11
0
infinite
0
--
TLR7
--
e12
cso30:c:Protein
cso30:i:CC_EndosomeLumen
--
--
csml-variable:Double
m12
0
infinite
0
--
TLR8
--
e13
cso30:c:Protein
cso30:i:CC_EndosomeLumen
--
--
csml-variable:Double
m13
0
infinite
0
--
TLR9
--
e14
cso30:c:Protein
cso30:i:CC_EndosomeLumen
--
--
csml-variable:Double
m14
0
infinite
0
--
csml-variable:Double
m15
0
infinite
0
--
csml-variable:Double
m16
0
infinite
0
--
CpG DNA: TLR9
--
e17
cso30:c:Complex
cso30:i:CC_EndosomeMembrane
--
csml-variable:Double
m17
0
infinite
0
--
ssRNA: TLR7: MyD88
--
e18
cso30:c:Complex
cso30:i:CC_EndosomeLumen
--
csml-variable:Double
m18
0
infinite
0
--
ssRNA: TLR8: MyD88
--
e19
cso30:c:Complex
cso30:i:CC_EndosomeMembrane
--
csml-variable:Double
m19
0
infinite
0
--
--
e2
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m2
0
infinite
0
--
CpG DNA: TLR9: MyD88
--
e20
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m20
0
infinite
0
--
MyD88
--
e21
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m21
0
infinite
0
--
ssRNA
--
e22
cso30:c:RnaOther
cso30:i:CC_Cytosol
--
csml-variable:Double
m22
0
infinite
0
--
csml-variable:Double
m23
0
infinite
0
--
dsRNA
--
e24
cso30:c:RnaOther
cso30:i:CC_Extracellular
--
csml-variable:Double
m24
0
infinite
0
--
TLR3
--
e25
cso30:c:Protein
cso30:i:CC_EndosomeLumen
--
--
csml-variable:Double
m25
0
infinite
0
--
dsRNA: TLR3
--
e26
cso30:c:Complex
cso30:i:CC_EndosomeLumen
--
csml-variable:Double
m26
0
infinite
0
--
TRIF
--
e27
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m27
0
infinite
0
--
dsRNA: TLR3: TRIF
--
e28
cso30:c:Complex
cso30:i:CC_EndosomeLumen
--
csml-variable:Double
m28
0
infinite
0
--
RIG-1
--
e29
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m29
0
infinite
0
--
--
e3
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
--
csml-variable:Double
m3
0
infinite
0
--
Mda-5
--
e30
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m30
0
infinite
0
--
csml-variable:Double
m31
0
infinite
0
--
csml-variable:Double
m32
0
infinite
0
--
--
e33
cso30:c:EntityBiologicalCompartment
cso30:i:CC_MitochondrialChromosome
--
--
--
csml-variable:Double
m33
0
infinite
0
--
--
e34
cso30:c:EntityBiologicalCompartment
cso30:i:CC_MitochondrialCentromere
--
--
--
csml-variable:Double
m34
0
infinite
0
--
--
e35
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Mitochondria
--
--
--
csml-variable:Double
m35
0
infinite
0
--
--
e36
cso30:c:EntityBiologicalCompartment
cso30:i:CC_MitochondrialIntermembraneSpace
--
--
--
csml-variable:Double
m36
0
infinite
0
--
--
e37
cso30:c:EntityBiologicalCompartment
cso30:i:CC_MitochondrialEnvelope
--
--
--
csml-variable:Double
m37
0
infinite
0
--
--
e38
cso30:c:EntityBiologicalCompartment
cso30:i:CC_MitochondrialInnerMembrane
--
--
--
csml-variable:Double
m38
0
infinite
0
--
--
e39
cso30:c:EntityBiologicalCompartment
cso30:i:CC_MitochondrialOuterMembrane
--
--
--
csml-variable:Double
m39
0
infinite
0
--
--
e4
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m4
0
infinite
0
--
--
e40
cso30:c:EntityBiologicalCompartment
cso30:i:CC_MitochondrialLumen
--
--
--
csml-variable:Double
m40
0
infinite
0
--
--
e41
cso30:c:EntityBiologicalCompartment
cso30:i:CC_MitochondrialMatrix
--
--
--
csml-variable:Double
m41
0
infinite
0
--
IPS-1
--
e42
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m42
0
infinite
0
--
dsRNA: RIG-1: IPS-1
--
e43
cso30:c:Complex
cso30:i:CC_MitochondrialIntermembraneSpace
--
csml-variable:Double
m43
0
infinite
0
--
dsRNA: Mda-5: IPS-1
--
e44
cso30:c:Complex
cso30:i:CC_MitochondrialIntermembraneSpace
--
csml-variable:Double
m44
0
infinite
0
--
TRAF3
--
e45
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m45
0
infinite
0
--
TRAF3{activated}
--
e46
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m46
0
infinite
0
--
TBK-1: IKK-i
--
e47
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m47
0
infinite
0
--
TBK-1: IKK-i{activated}
--
e48
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m48
0
infinite
0
--
IRF-3
--
e49
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m49
0
infinite
0
--
--
e5
cso30:c:EntityBiologicalCompartment
cso30:i:CC_EndosomeMembrane
--
--
--
csml-variable:Double
m5
0
infinite
0
--
--
e50
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelopeLumen
--
--
--
csml-variable:Double
m50
0
infinite
0
--
--
e51
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearPore
--
--
--
csml-variable:Double
m51
0
infinite
0
--
--
e52
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearInnerMembrane
--
--
--
csml-variable:Double
m52
0
infinite
0
--
--
e53
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearLumen
--
--
--
csml-variable:Double
m53
0
infinite
0
--
--
e54
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearOuterMembrane
--
--
--
csml-variable:Double
m54
0
infinite
0
--
--
e55
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleus
--
--
--
csml-variable:Double
m55
0
infinite
0
--
--
e56
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleoplasm
--
--
--
csml-variable:Double
m56
0
infinite
0
--
--
e57
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearBody
--
--
--
csml-variable:Double
m57
0
infinite
0
--
--
e58
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleolus
--
--
--
csml-variable:Double
m58
0
infinite
0
--
--
e59
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelope
--
--
--
csml-variable:Double
m59
0
infinite
0
--
--
e6
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Endosome
--
--
--
csml-variable:Double
m6
0
infinite
0
--
--
e60
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Chromatin
--
--
--
csml-variable:Double
m60
0
infinite
0
--
--
e61
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearChromosome
--
--
--
csml-variable:Double
m61
0
infinite
0
--
--
e62
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearCentromere
--
--
--
csml-variable:Double
m62
0
infinite
0
--
IRF-3{activated}
--
e63
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m63
0
infinite
0
--
IRF-7
--
e64
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m64
0
infinite
0
--
IRF-7{activated}
--
e65
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m65
0
infinite
0
--
IKK-alpha: IKK-beta: IKK-gamma
--
e66
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m66
0
infinite
0
--
IKK-alpha: IKK-beta: IKK-gamma{activated}
--
e67
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m67
0
infinite
0
--
NF-kappaB
--
e68
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m68
0
infinite
0
--
NF-kappaB{activated}
--
e69
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m69
0
infinite
0
--
--
e7
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell
--
--
--
csml-variable:Double
m7
0
infinite
0
--
IRAK1: IRAK4
--
e70
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m70
0
infinite
0
--
IRAK1: IRAK4{activated}
--
e71
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m71
0
infinite
0
--
TRAF6
--
e72
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m72
0
infinite
0
--
TRAF6{activated}
--
e73
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m73
0
infinite
0
--
IRF-3: IRF-7 {activated}
--
e74
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m74
0
infinite
0
--
IRF-3: IRF-7 {nuclear}
--
e75
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m75
0
infinite
0
--
IFN-beta
--
e76
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m76
0
infinite
0
--
NF-kappaB{nucleus}
--
e77
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m77
0
infinite
0
--
IFN-alpha4
--
e78
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m78
0
infinite
0
--
--
e8
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell_WithoutCellWall_
--
--
--
csml-variable:Double
m8
0
infinite
0
--
--
e9
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytoplasm
--
--
--
csml-variable:Double
m9
0
infinite
0
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c17 : 1
stoichiometry:c5 : 1
m12*m22*0.1
nodelay
--
0
PMID: 17395579 TLR7 and -8 (when activated by ssRNA) and TLR9 (when activated by CpG-rich DNA) mediate MyD88-dependent adaptor signaling.
p10
p10
cso30:i:ME_Binding
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c27 : 1
stoichiometry:c28 : 1
m24*m29*0.1
nodelay
--
0
PMID: 17395579 The interaction of RNA with the RIG-I or MDA5 cytosolic cellular helicase mediates signaling via CARD domain interactions between the helicase sensor and a mitochondrial membrane-associated adaptor protein known variously as IPS-1, CARDIF, MAVS, and VISA.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1
stoichiometry:c33 : 1
m31*m42*0.1
nodelay
--
0
PMID: 17395579 The interaction of RNA with the RIG-I or MDA5 cytosolic cellular helicase mediates signaling via CARD domain interactions between the helicase sensor and a mitochondrial membrane-associated adaptor protein known variously as IPS-1, CARDIF, MAVS, and VISA.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c35 : 1
stoichiometry:c36 : 1
m42*m32*0.1
nodelay
--
0
PMID: 17395579 The interaction of RNA with the RIG-I or MDA5 cytosolic cellular helicase mediates signaling via CARD domain interactions between the helicase sensor and a mitochondrial membrane-associated adaptor protein known variously as IPS-1, CARDIF, MAVS, and VISA.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c39 : 1
stoichiometry:c38 : 1
m45*m28*0.1
nodelay
--
0
PMID: 17395579 The IPS-1, TRIF, and MyD88 adaptors then lead to IRF and NF-kappaB activation via IKK (inhibitor of nuclear factor-{kappa}B kinase), IRAK (interleukin 1 receptor-associated kinase), TBK (TANK-binding kinase), and TRAF (tumor necrosis factor receptor-associated factor) proteins.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c42 : 1
stoichiometry:c41 : 1
m47*m46*0.1
nodelay
--
0
PMID: 17395579 The IPS-1, TRIF, and MyD88 adaptors then lead to IRF and NF-kappaB activation via IKK (inhibitor of nuclear factor-{kappa}B kinase), IRAK (interleukin 1 receptor-associated kinase), TBK (TANK-binding kinase), and TRAF (tumor necrosis factor receptor-associated factor) proteins.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c47 : 1
stoichiometry:c44 : 1
m49*m48*0.1
nodelay
--
0
PMID: 17395579 The IPS-1, TRIF, and MyD88 adaptors then lead to IRF and NF-kappaB activation via IKK (inhibitor of nuclear factor-{kappa}B kinase), IRAK (interleukin 1 receptor-associated kinase), TBK (TANK-binding kinase), and TRAF (tumor necrosis factor receptor-associated factor) proteins.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c48 : 1
stoichiometry:c46 : 1
m64*m48*0.1
nodelay
--
0
PMID: 17395579 The IPS-1, TRIF, and MyD88 adaptors then lead to IRF and NF-kappaB activation via IKK (inhibitor of nuclear factor-{kappa}B kinase), IRAK (interleukin 1 receptor-associated kinase), TBK (TANK-binding kinase), and TRAF (tumor necrosis factor receptor-associated factor) proteins.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c50 : 1
stoichiometry:c51 : 1
m28*m66*0.1
nodelay
--
0
PMID: 17395579 The IPS-1, TRIF, and MyD88 adaptors then lead to IRF and NF-kappaB activation via IKK (inhibitor of nuclear factor-{kappa}B kinase), IRAK (interleukin 1 receptor-associated kinase), TBK (TANK-binding kinase), and TRAF (tumor necrosis factor receptor-associated factor) proteins.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c54 : 1
stoichiometry:c53 : 1
m68*m67*0.1
nodelay
--
0
PMID: 17395579 The IPS-1, TRIF, and MyD88 adaptors then lead to IRF and NF-kappaB activation via IKK (inhibitor of nuclear factor-{kappa}B kinase), IRAK (interleukin 1 receptor-associated kinase), TBK (TANK-binding kinase), and TRAF (tumor necrosis factor receptor-associated factor) proteins.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c61 : 1
stoichiometry:c56 : 1
m70*m18*0.1
nodelay
--
0
PMID: 17395579 The IPS-1, TRIF, and MyD88 adaptors then lead to IRF and NF-kappaB activation via IKK (inhibitor of nuclear factor-{kappa}B kinase), IRAK (interleukin 1 receptor-associated kinase), TBK (TANK-binding kinase), and TRAF (tumor necrosis factor receptor-associated factor) proteins.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c6 : 1
stoichiometry:c7 : 1
m21*m15*0.1
nodelay
--
0
PMID: 17395579 TLR7 and -8 (when activated by ssRNA) and TLR9 (when activated by CpG-rich DNA) mediate MyD88-dependent adaptor signaling.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c57 : 1
stoichiometry:c62 : 1
stoichiometry:c58 : 1
m70*m19*0.1
nodelay
--
0
PMID: 17395579 The IPS-1, TRIF, and MyD88 adaptors then lead to IRF and NF-kappaB activation via IKK (inhibitor of nuclear factor-{kappa}B kinase), IRAK (interleukin 1 receptor-associated kinase), TBK (TANK-binding kinase), and TRAF (tumor necrosis factor receptor-associated factor) proteins.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c63 : 1
stoichiometry:c60 : 1
m70*m20*0.1
nodelay
--
0
PMID: 17395579 The IPS-1, TRIF, and MyD88 adaptors then lead to IRF and NF-kappaB activation via IKK (inhibitor of nuclear factor-{kappa}B kinase), IRAK (interleukin 1 receptor-associated kinase), TBK (TANK-binding kinase), and TRAF (tumor necrosis factor receptor-associated factor) proteins.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c64 : 1
stoichiometry:c66 : 1
stoichiometry:c65 : 1
m72*m71*0.1
nodelay
--
0
PMID: 17395579 The IPS-1, TRIF, and MyD88 adaptors then lead to IRF and NF-kappaB activation via IKK (inhibitor of nuclear factor-{kappa}B kinase), IRAK (interleukin 1 receptor-associated kinase), TBK (TANK-binding kinase), and TRAF (tumor necrosis factor receptor-associated factor) proteins.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c69 : 1
stoichiometry:c68 : 1
m64*m73*0.1
nodelay
--
0
PMID: 17395579 The IPS-1, TRIF, and MyD88 adaptors then lead to IRF and NF-kappaB activation via IKK (inhibitor of nuclear factor-{kappa}B kinase), IRAK (interleukin 1 receptor-associated kinase), TBK (TANK-binding kinase), and TRAF (tumor necrosis factor receptor-associated factor) proteins.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1
stoichiometry:c71 : 1
stoichiometry:c72 : 1
m63*m65*0.1
nodelay
--
0
PMID: 17395579 The IPS-1, TRIF, and MyD88 adaptors then lead to IRF and NF-kappaB activation via IKK (inhibitor of nuclear factor-{kappa}B kinase), IRAK (interleukin 1 receptor-associated kinase), TBK (TANK-binding kinase), and TRAF (tumor necrosis factor receptor-associated factor) proteins.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c74 : 1
m74*0.1
nodelay
--
0
PMID: 17395579 Translocation into the nucleus of IRF dimers (IRF-3, IRF-7) and activated NF-kappaB lead to transcriptional activation of type I interferon gene expression (for example IFN-beta and IFN-alpha4).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c75 : 1
stoichiometry:c76 : 1
m75*0.1
nodelay
--
0
PMID: 17395579 Translocation into the nucleus of IRF dimers (IRF-3, IRF-7) and activated NF-kappaB lead to transcriptional activation of type I interferon gene expression (for example IFN-beta and IFN-alpha4).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c82 : 1
stoichiometry:c78 : 1
m45*m44*0.1
nodelay
--
0
PMID: 17395579 The IPS-1, TRIF, and MyD88 adaptors then lead to IRF and NF-kappaB activation via IKK (inhibitor of nuclear factor-{kappa}B kinase), IRAK (interleukin 1 receptor-associated kinase), TBK (TANK-binding kinase), and TRAF (tumor necrosis factor receptor-associated factor) proteins.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c81 : 1
stoichiometry:c80 : 1
m45*m43*0.1
nodelay
--
0
PMID: 17395579 The IPS-1, TRIF, and MyD88 adaptors then lead to IRF and NF-kappaB activation via IKK (inhibitor of nuclear factor-{kappa}B kinase), IRAK (interleukin 1 receptor-associated kinase), TBK (TANK-binding kinase), and TRAF (tumor necrosis factor receptor-associated factor) proteins.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c84 : 1
m69*0.1
nodelay
--
0
PMID: 17395579 Translocation into the nucleus of IRF dimers (IRF-3, IRF-7) and activated NF-kappaB lead to transcriptional activation of type I interferon gene expression (for example IFN-beta and IFN-alpha4).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c8 : 1
stoichiometry:c16 : 1
stoichiometry:c9 : 1
m13*m22*0.1
nodelay
--
0
PMID: 17395579 TLR7 and -8 (when activated by ssRNA) and TLR9 (when activated by CpG-rich DNA) mediate MyD88-dependent adaptor signaling.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c88 : 1
m77*0.1
nodelay
--
0
PMID: 17395579 Translocation into the nucleus of IRF dimers (IRF-3, IRF-7) and activated NF-kappaB lead to transcriptional activation of type I interferon gene expression (for example IFN-beta and IFN-alpha4).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c85 : 1
stoichiometry:c89 : 1
m75*0.1
nodelay
--
0
PMID: 17395579 Translocation into the nucleus of IRF dimers (IRF-3, IRF-7) and activated NF-kappaB lead to transcriptional activation of type I interferon gene expression (for example IFN-beta and IFN-alpha4).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c90 : 1
m77*0.1
nodelay
--
0
PMID: 17395579 Translocation into the nucleus of IRF dimers (IRF-3, IRF-7) and activated NF-kappaB lead to transcriptional activation of type I interferon gene expression (for example IFN-beta and IFN-alpha4).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c12 : 1
stoichiometry:c18 : 1
stoichiometry:c13 : 1
m14*m23*0.1
nodelay
--
0
PMID: 17395579 TLR7 and -8 (when activated by ssRNA) and TLR9 (when activated by CpG-rich DNA) mediate MyD88-dependent adaptor signaling.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c2 : 1
stoichiometry:c10 : 1
stoichiometry:c11 : 1
m21*m16*0.1
nodelay
--
0
PMID: 17395579 TLR7 and -8 (when activated by ssRNA) and TLR9 (when activated by CpG-rich DNA) mediate MyD88-dependent adaptor signaling.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c3 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1
m21*m17*0.1
nodelay
--
0
PMID: 17395579 TLR7 and -8 (when activated by ssRNA) and TLR9 (when activated by CpG-rich DNA) mediate MyD88-dependent adaptor signaling.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1
m25*m24*0.1
nodelay
--
0
PMID: 17395579 TLR3 when activated by dsRNA mediates MyD88-independent signaling via the TRIF adaptor protein.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1
m26*m27*0.1
nodelay
--
0
PMID: 17395579 TLR3 when activated by dsRNA mediates MyD88-independent signaling via the TRIF adaptor protein.
p9
p9
cso30:i:ME_Binding
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c26 : 1
stoichiometry:c29 : 1
stoichiometry:c30 : 1
m24*m30*0.1
nodelay
--
0
PMID: 17395579 The interaction of RNA with the RIG-I or MDA5 cytosolic cellular helicase mediates signaling via CARD domain interactions between the helicase sensor and a mitochondrial membrane-associated adaptor protein known variously as IPS-1, CARDIF, MAVS, and VISA.
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--