Entity
proCaspase-9
--
MO000017811
cso30:c:Protein
cso30:i:CC_CellComponent
--
--
csml-variable:Double
m2563
10
infinite
0
InterPro | IPR001309 |
TRANSPATH | MO000017811 |
--
RIP2
--
MO000017949
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m2684
10
infinite
0
InterPro | IPR000719 |
TRANSPATH | MO000017949 |
--
proCaspase-1
--
MO000018229
cso30:c:Protein
cso30:i:CC_CellComponent
--
--
csml-variable:Double
m2906
10
infinite
0
InterPro | IPR001309 |
TRANSPATH | MO000018229 |
--
proIL-1beta
--
MO000019449
cso30:c:Protein
cso30:i:CC_CellComponent
--
--
csml-variable:Double
m4012
10
infinite
0
InterPro | IPR003297 |
TRANSPATH | MO000019449 |
--
Nod2
--
MO000020461
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m4947
10
infinite
0
TRANSPATH | MO000020461 |
--
--
e1
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane
--
--
--
csml-variable:Double
m1
0
infinite
0
--
--
e10
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytosol
--
--
--
csml-variable:Double
m10
0
infinite
0
--
muramyl dipeptide:Nod2
--
e11
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m11
0
infinite
0
--
diaminopimelic acid
--
e12
cso30:c:SmallMolecule
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m12
0
infinite
0
--
diaminopimelic acid:Nod1
--
e13
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m13
0
infinite
0
--
Mda5
--
e14
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m14
0
infinite
0
--
dsRNA:Mda5
--
e15
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m15
0
infinite
0
--
(diaminopimelic acid:Nod1)2
--
e16
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m16
0
infinite
0
--
(diaminopimelic acid:Nod1)2 :RIP2
--
e17
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m17
0
infinite
0
--
(muramyl dipeptide:Nod2)2
--
e18
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m18
0
infinite
0
--
(muramyl dipeptide:Nod2)2: RIP2
--
e19
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m19
0
infinite
0
--
--
e2
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m2
0
infinite
0
--
(diaminopimelic acid:Nod1)2 :RIP2:IKK
--
e20
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m20
0
infinite
0
--
IKK-gamma{ub}
--
e21
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m21
0
infinite
0
--
procaspase-9:Nod1
--
e22
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m22
0
infinite
0
--
inflammosome
--
e23
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m23
0
infinite
0
--
NALP
--
e24
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m24
0
infinite
0
--
DPA:Nod1:RIP2:procaspase-1
--
e25
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m25
0
infinite
0
--
Nalp3
--
e26
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m26
0
infinite
0
--
MDP:Nalp3
--
e27
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m27
0
infinite
0
--
inflammosome{active}
--
e28
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m28
0
infinite
0
--
Rip2:TRIP6
--
e29
cso30:c:Complex
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m29
0
infinite
0
--
--
e3
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
--
csml-variable:Double
m3
0
infinite
0
--
TAK1:Nod2
--
e30
cso30:c:Complex
cso30:i:CC_Extracellular
--
csml-variable:Double
m30
0
infinite
0
--
Nod2:Erbin
--
e32
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m33
0
infinite
0
--
--
e4
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m4
0
infinite
0
--
dsRNA:DDX58
--
e5
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m5
0
infinite
0
--
--
e50
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelopeLumen
--
--
--
csml-variable:Double
m50
0
infinite
0
--
--
e51
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearPore
--
--
--
csml-variable:Double
m51
0
infinite
0
--
--
e52
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearInnerMembrane
--
--
--
csml-variable:Double
m52
0
infinite
0
--
--
e53
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearLumen
--
--
--
csml-variable:Double
m53
0
infinite
0
--
--
e54
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearOuterMembrane
--
--
--
csml-variable:Double
m54
0
infinite
0
--
--
e55
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleus
--
--
--
csml-variable:Double
m55
0
infinite
0
--
--
e56
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleoplasm
--
--
--
csml-variable:Double
m56
0
infinite
0
--
--
e57
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearBody
--
--
--
csml-variable:Double
m57
0
infinite
0
--
--
e58
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleolus
--
--
--
csml-variable:Double
m58
0
infinite
0
--
--
e59
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelope
--
--
--
csml-variable:Double
m59
0
infinite
0
--
muramyl dipeptide
--
e6
cso30:c:SmallMolecule
cso30:i:CC_Cytosol
--
csml-variable:Double
m6
0
infinite
0
--
--
e60
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Chromatin
--
--
--
csml-variable:Double
m60
0
infinite
0
--
--
e61
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearChromosome
--
--
--
csml-variable:Double
m61
0
infinite
0
--
--
e62
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearCentromere
--
--
--
csml-variable:Double
m62
0
infinite
0
--
--
e7
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell
--
--
--
csml-variable:Double
m7
0
infinite
0
--
--
e8
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell_WithoutCellWall_
--
--
--
csml-variable:Double
m8
0
infinite
0
--
--
e9
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytoplasm
--
--
--
csml-variable:Double
m9
0
infinite
0
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c2 : 1
stoichiometry:c1 : 1
stoichiometry:c3 : 1
m6*m4947*0.1
nodelay
--
0
PMID: 17379560, 12527755, 12514169 Nod2 senses both Gram-negative and Gram-positive bacteria since it recognizes MDP.
p10
p10
cso30:i:ME_Ubiquitination
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c26 : 1
stoichiometry:c28 : 1
stoichiometry:c29 : 1
stoichiometry:c27 : 1
m1593*m19*m2684*0.1
nodelay
--
0
PMID: 17379560, 15620648 Activation of Nod2 has been shown to induce a RIP2-dependent ubiquitinylation of NEMO (IKK¦Ã), at a novel site, resulting in enhanced NF-¦ÊB signaling
p11
p11
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c30 : 1
stoichiometry:c31 : 1
stoichiometry:c32 : 1
m4923*m2563*0.1
nodelay
--
0
PMID: 17379560, 10329646 Nod1 has been shown to bind to pro-caspase 9, through homophilic CARD-CARD interactions and up-regulate caspase-9 induced apoptosis.
p12
p12
cso30:i:ME_Cleavage
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c33 : 1
stoichiometry:c45 : 1
stoichiometry:c51 : 1
stoichiometry:c34 : 1
m4012*m25*m28*0.1
nodelay
--
0
PMID: 17379560 pro-IL-1? processing and IL-1? secretion relies on cleavage of pro-IL-1? by caspase-1. This process takes place in a protein complex recently described as the ¡Èinflammasome¡É.
p13
p13
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c36 : 1
stoichiometry:c38 : 1
stoichiometry:c39 : 1
stoichiometry:c37 : 1
m1765*m2380*m21736*m24*0.1
nodelay
--
0
PMID: 17379560, 12191486 The ¡Èinflammasome¡É comprises of caspase-1 and -5, the adaptor protein ASC, which bears a CARD and a PYRIN domain, and several members from the Nalp family, which are NACHT proteins bearing both a PYRIN and a LRR domain.
p14
p14
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c41 : 1
stoichiometry:c42 : 1
stoichiometry:c43 : 1
stoichiometry:c44 : 1
m2684*m2906*m13*0.1
nodelay
--
0
PMID: 17379560, 12459189 Nod1 enhances pro-interleukin-1? processing through heterophilic CARD-CARD interactions between Nod1, RIP2 and pro-caspase-1.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c47 : 1
stoichiometry:c48 : 1
m26*m6*0.1
nodelay
--
0
PMID: 17379560, 15530394 It has also been published that MDP can activate the inflammasome through binding to Nalp3 (cryopyrin).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c50 : 1
stoichiometry:c49 : 1
m23*m27*0.1
nodelay
--
0
PMID: 17379560, 15530394 It has also been published that MDP can activate the inflammasome through binding to Nalp3 (cryopyrin).
p17
p17
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c53 : 1
stoichiometry:c54 : 1
m36881*m2684*0.1
nodelay
--
0
PMID: 17379560, 15657077 TRIP-6, a LIM-domain containing protein, can potentiate Nod1 activation, most likely through its interaction with RIP2.
p18
p18
cso30:i:ME_Binding
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c56 : 1
stoichiometry:c57 : 1
m4947*m1573*0.1
nodelay
--
0
PMID: 17379560, 15075345 TAK1 and Nod2 have been shown to interact through the LRR domain of Nod2 and to reciprocally negatively regulate NF-¦ÊB activation.
p19
p19
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c60 : 1
stoichiometry:c64 : 1
stoichiometry:c65 : 1
stoichiometry:c59 : 1
m31*m21*0.1
nodelay
--
0
PMID: 17379560, 15075345 TAK1 and Nod2 have been shown to interact through the LRR domain of Nod2 and to reciprocally negatively regulate NF-¦ÊB activation. PMID: 17379560, 16714539, 16203728 ERBIN appears to be a negative regulator of Nod2 dependent NF-¦ÊB and MAP kinases signaling PMID: 17379560, 15620648 More recently, activation of Nod2 has been shown to induce a RIP2-dependent ubiquitinylation of NEMO (IKKg), at a novel site, resulting in enhanced NFkB signaling
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1
m4923*m12*0.1
nodelay
--
0
PMID: 17379560, 12791997 Nod1, in contrast, has a narrow specificity and recognizes only diaminopimelic acid (DAP) type PG.
p20
p20
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c62 : 1
stoichiometry:c63 : 1
m4947*m12851*0.1
nodelay
--
0
PMID: 17379560 ERBIN, a member of the LAP (LRR and PDZ domain) protein family involved in cell polarity, as a new binding partner of Nod2.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1
m41844*m119368*0.1
nodelay
--
0
PMID: 17379560 Very recently RIG-I and MDA-5 helicases have been shown to be intracellular sensors of viral double strand RNA.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1
m119368*m14*0.1
nodelay
--
0
PMID: 17379560 Very recently RIG-I and MDA-5 helicases have been shown to be intracellular sensors of viral double strand RNA.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
m13*0.1
nodelay
--
0
PMID: 17379560, 10880512 Ligand recognition by the LRR domain of Nod1 or Nod2 is thought to induce a conformational change, allowing for the oligomerization of the molecule via the NACHT domain, and subsequent recruitment of the CARD domain adaptor RIP2 (RICK).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c16 : 1
stoichiometry:c17 : 1
m2684*m16*0.1
nodelay
--
0
PMID: 17379560, 10880512 Ligand recognition by the LRR domain of Nod1 or Nod2 is thought to induce a conformational change, allowing for the oligomerization of the molecule via the NACHT domain, and subsequent recruitment of the CARD domain adaptor RIP2 (RICK).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c18 : 1
stoichiometry:c19 : 1
m11*0.1
nodelay
--
0
PMID: 17379560, 10880512 Ligand recognition by the LRR domain of Nod1 or Nod2 is thought to induce a conformational change, allowing for the oligomerization of the molecule via the NACHT domain, and subsequent recruitment of the CARD domain adaptor RIP2 (RICK).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c20 : 1
stoichiometry:c21 : 1
stoichiometry:c22 : 1
m18*m2684*0.1
nodelay
--
0
PMID: 17379560, 10880512 Ligand recognition by the LRR domain of Nod1 or Nod2 is thought to induce a conformational change, allowing for the oligomerization of the molecule via the NACHT domain, and subsequent recruitment of the CARD domain adaptor RIP2 (RICK).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c24 : 1
stoichiometry:c25 : 1
m17*m207*0.1
nodelay
--
0
PMID: 17379560, 11463746 Upon Nod1 activation, a transient interaction between Nod1, RIP2 and IKKs occurs, which is suggestive of a mechanism of down-regulation.
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--