majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:17336545.csml convertedTime:2009.07.01.11:01

Entity

MO000000058:NF-kappaB MO000007694:IRF-3 MO000007702:IRF-7 MO000016573:MyD88 MO000019394:TLR4 MO000019397:TLR2 MO000019398:TLR3 MO000022224:dsRNA MO000041125:TRIF MO000041437:dsRNA:TLR3:TRIF MO000041446:dsRNA:TLR3 MO000042007:TLR8 MO000042012:TLR9 MO000042126:TLR7 e1: e10:ssRNA e11: e12:TLR7:ssRNA e13:TLR8:ssRNA e14:Viral protein e15:TLR4:viral protein e16:TLR2:viral protein e17:NF-kappaB{active} e18:IRF-3{active} e19:TLR7:ssRNA:MyD88 e2: e20:TLR8:ssRNA:MyD88 e21:TLR9:ssRNA:MyD88 e22:IRF-7{active} e23:Type I IFNs e3: e4: e5: e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6: e60: e61: e62: e7:CpG DNA e8: e9:TLR9:CpGDNA

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p3 p4 p5 p6 p7 p8 p9
293.0, 617.0
22.0, 22.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8 p13 p14 p15

true true true true

csml-variable:Double

m17

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
685.0, 697.0
22.0, 22.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
401.0, 841.0
22.0, 22.0

IRF-7

--

MO000007702

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16 p17 p18

true true true true

csml-variable:Double

m980

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
546.0, 194.0
20.0, 20.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10 p11 p12

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
313.0, 137.0
22.0, 22.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
213.0, 189.0
21.0, 21.0

TLR2

--

MO000019397

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6

true true true true

csml-variable:Double

m3964

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019397

--

Go back
827.0, 323.0
18.0, 18.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
1057.0, 237.0
22.0, 22.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
554.0, 562.0
20.0, 20.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
725.0, 517.0
22.0, 22.0

dsRNA:TLR3:TRIF

--

MO000041437

cso30:c:Protein

cso30:i:CC_CellComponent

--

p7

p8 p9

true true true true

csml-variable:Double

m19305

10

false

infinite

0

unit false false false
TRANSPATHMO000041437

--

Go back
738.0, 310.0
20.0, 20.0

dsRNA:TLR3

--

MO000041446

cso30:c:Protein

cso30:i:CC_CellComponent

--

p1

p7

true true true true

csml-variable:Double

m19314

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
861.0, 137.0
22.0, 22.0

TLR8

--

MO000042007

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4

true true true true

csml-variable:Double

m19823

10

false

infinite

0

unit false false false
TRANSPATHMO000042007

--

Go back
906.0, 458.0
20.0, 20.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
598.0, 138.0
20.0, 20.0

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
194.80718040271157, 114.07828493854828
850.9620492815882, 1235.5968955568644

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
678.0, 38.5
60.0, 19.0

ssRNA

--

e10

cso30:c:Dna

cso30:i:CC_Cell_WithoutCellWall_

--

--

p3 p4

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false false false

--

Go back
712.0, 298.0
223.22503934917393, 372.67231145582434

--

e11

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false true false

--

Go back
677.5, 123.0
21.844770883578164, 42.28020171015128

TLR7:ssRNA

--

e12

cso30:c:Complex

cso30:i:CC_Cell_WithoutCellWall_

--

p3

p10

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
769.5, 111.0
21.844770883578164, 42.28020171015128

TLR8:ssRNA

--

e13

cso30:c:Complex

cso30:i:CC_Cell_WithoutCellWall_

--

p4

p11

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
272.0, 72.5
23.485610786878645, 14.482793318575165

Viral protein

--

e14

cso30:c:Protein

cso30:i:CC_Cell_WithoutCellWall_

--

--

p5 p6

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
401.5, 116.0
21.165095373821533, 40.964700723525546

TLR4:viral protein

--

e15

cso30:c:Complex

cso30:i:CC_Cell_WithoutCellWall_

--

p5

--

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
253.5, 124.0
21.165095373821533, 40.964700723525546

TLR2:viral protein

--

e16

cso30:c:Complex

cso30:i:CC_Cell_WithoutCellWall_

--

p6

--

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
381.0, 761.0
22.0, 22.0

NF-kappaB{active}

--

e17

cso30:c:Protein

cso30:i:CC_CellComponent

--

p8 p13 p14 p15

p19

true true true true

csml-variable:Double

m18

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
593.0, 761.0
22.0, 22.0

IRF-3{active}

--

e18

cso30:c:Protein

cso30:i:CC_CellComponent

--

p9

p20

true true true true

csml-variable:Double

m19

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
549.5, 141.0
21.37768397871169, 29.82932648192328

TLR7:ssRNA:MyD88

--

e19

cso30:c:Complex

cso30:i:CC_Cell_WithoutCellWall_

--

p10

p13 p16

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
194.80718040271157, 114.07828493854828
850.9620492815882, 1235.5968955568644

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
997.5, 141.0
21.37768397871169, 29.82932648192328

TLR8:ssRNA:MyD88

--

e20

cso30:c:Complex

cso30:i:CC_Cell_WithoutCellWall_

--

p11

p14 p17

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
737.5, 369.0
21.37768397871169, 29.82932648192328

TLR9:ssRNA:MyD88

--

e21

cso30:c:Complex

cso30:i:CC_Cell_WithoutCellWall_

--

p12

p15 p18

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
695.0, 795.0
26.0, 26.0

IRF-7{active}

--

e22

cso30:c:Protein

cso30:i:CC_CellComponent

--

p16 p17 p18

p21

true true true true

csml-variable:Double

m23

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
598.0, 1046.0
51.90311418685121, 27.68166089965398

Type I IFNs

--

e23

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p19 p20 p21

--

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
211.82642138834325, 131.09752592418005
816.9235673103249, 1201.558413585603

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
243.31201721176214, 160.88119764903553
753.9523756634868, 1141.9910701358906

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
712.0, 298.0
223.22503934917393, 372.67231145582434

--

e5

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false true false

--

Go back
429.1193330143543, 878.2242233542319
374.23277178859917, 339.3880071900333

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
469.53925994869087, 886.2672257320801
218.82512167899472, 328.9345778104634

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
433.99760005815364, 882.754042752045
364.4762377010009, 330.32836839440597

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
434.6944953501249, 883.4509380440167
363.08244711705805, 328.9345778104634

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
429.1193330143543, 878.2242233542319
374.23277178859917, 339.3880071900333

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
429.1193330143543, 878.2242233542319
374.23277178859917, 339.3880071900333

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
434.6944953501249, 883.4509380440167
363.08244711705805, 328.9345778104634

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
702.3022874671117, 1017.6032817484966
23.380007357862496, 21.165059292380818

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
640.9755017736361, 1115.1686226244806
66.20505273727545, 59.93299510953357

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
429.1193330143543, 878.2242233542319
374.23277178859917, 339.3880071900333

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
712.0, 298.0
223.22503934917393, 372.67231145582434

--

e6

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false true false

--

Go back
517.323891662056, 1029.045449363291
11.851402005248033, 5.706230595119427

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
516.9281398027406, 1012.0281194127249
40.56456557984007, 73.01621804371213

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
533.9454697533079, 1059.518342530587
6.332029749048204, 6.332029749048199

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
1058.0, 445.5
60.0, 13.0

CpG DNA

--

e7

cso30:c:Dna

cso30:i:CC_Cell_WithoutCellWall_

--

--

p2

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false false false

--

Go back
203.96335359956785, 157.09330846202485
791.3467744400882, 1149.035516487007

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
721.5, 423.0
21.844770883578164, 42.28020171015128

TLR9:CpGDNA

--

e9

cso30:c:Complex

cso30:i:CC_Cell_WithoutCellWall_

--

p2

p12

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false false false

--

Go back
826.0, 238.0
19.0, 19.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cell_WithoutCellWall_

--

MO000019398 MO000022224

MO000041446

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m3965*m119368*0.1

nodelay

--

true

0

false

PMID: 17336545,11607032,11130078,14976261,14976262,15034168 TLR3 recognizes double-stranded RNA (dsRNA),TLR9 recognizes nonmethylated CpG motifs in DNA (CpG DNA), and TLR7 and TLR8 recognize single-stranded RNA (ssRNA)

Go back
618.0, 234.0
19.0, 19.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Cell_WithoutCellWall_

--

e12 MO000016573

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c29 : 1
stoichiometry:c30 : 1

m12*m1572*0.1

nodelay

--

true

0

false

PMID: 17336545 In contrast, TLR7, TLR8, and TLR9 signal through MyD88 and activate NF-KappaB and IRF7.

Go back
762.0, 194.0
19.0, 19.0

p10

p11

cso30:i:ME_Binding

cso30:i:CC_Cell_WithoutCellWall_

--

MO000016573 e13

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1
stoichiometry:c33 : 1

m1572*m13*0.1

nodelay

--

true

0

false

PMID: 17336545 In contrast, TLR7, TLR8, and TLR9 signal through MyD88 and activate NF-KappaB and IRF7.

Go back
566.0, 374.0
19.0, 19.0

p10

p12

cso30:i:ME_Binding

cso30:i:CC_Cell_WithoutCellWall_

--

MO000016573 e9

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c35 : 1
stoichiometry:c36 : 1

m1572*m9*0.1

nodelay

--

true

0

false

PMID: 17336545 In contrast, TLR7, TLR8, and TLR9 signal through MyD88 and activate NF-KappaB and IRF7.

Go back
322.0, 446.0
19.0, 19.0

p13

p13

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell_WithoutCellWall_

--

e19 MO000000058

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c38 : 1
stoichiometry:c39 : 1

m20*m17*0.1

nodelay

--

true

0

false

PMID: 17336545 In contrast, TLR7, TLR8, and TLR9 signal through MyD88 and activate NF-KappaB and IRF7.

Go back
466.0, 370.0
19.0, 19.0

p13

p14

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell_WithoutCellWall_

--

e20 MO000000058

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1
stoichiometry:c42 : 1

m21*m17*0.1

nodelay

--

true

0

false

PMID: 17336545 In contrast, TLR7, TLR8, and TLR9 signal through MyD88 and activate NF-KappaB and IRF7.

Go back
478.0, 442.0
22.0, 22.0

p13

p15

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell_WithoutCellWall_

--

e21 MO000000058

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c44 : 1
stoichiometry:c45 : 1

m22*m17*0.1

nodelay

--

true

0

false

PMID: 17336545 In contrast, TLR7, TLR8, and TLR9 signal through MyD88 and activate NF-KappaB and IRF7.

Go back
486.0, 798.0
20.0, 20.0

p16

p16

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell_WithoutCellWall_

--

e19 MO000007702

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c47 : 1
stoichiometry:c48 : 1

m20*m980*0.1

nodelay

--

true

0

false

PMID: 17336545 In contrast, TLR7, TLR8, and TLR9 signal through MyD88 and activate NF-KappaB and IRF7.

Go back
550.0, 458.0
20.0, 20.0

p16

p17

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell_WithoutCellWall_

--

e20 MO000007702

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c50 : 1
stoichiometry:c51 : 1

m21*m980*0.1

nodelay

--

true

0

false

PMID: 17336545 In contrast, TLR7, TLR8, and TLR9 signal through MyD88 and activate NF-KappaB and IRF7.

Go back
630.0, 538.0
20.0, 20.0

p16

p18

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell_WithoutCellWall_

--

e21 MO000007702

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c53 : 1
stoichiometry:c54 : 1

m22*m980*0.1

nodelay

--

true

0

false

PMID: 17336545 In contrast, TLR7, TLR8, and TLR9 signal through MyD88 and activate NF-KappaB and IRF7.

Go back
525.0, 953.0
21.0, 21.0

p19

p19

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e17

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c56 : 1

m18*0.1

nodelay

--

true

0

false

PMID: 17334565 Both pathways are capable of inducing type I IFNs, but the MyD88-IRF7 pathway appears to function only in pDCs while the Trif pathway appears to function in all cell types.

Go back
930.0, 346.0
19.0, 19.0

p1

p2

cso30:i:ME_Binding

cso30:i:CC_Cell_WithoutCellWall_

--

e7 MO000042012

e9

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m7*m19828*0.1

nodelay

--

true

0

false

PMID: 17336545,11607032,11130078,14976261,14976262,15034168 TLR3 recognizes double-stranded RNA (dsRNA),TLR9 recognizes nonmethylated CpG motifs in DNA (CpG DNA), and TLR7 and TLR8 recognize single-stranded RNA (ssRNA)

Go back
601.0, 933.0
21.0, 21.0

p19

p20

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e18

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c57 : 1
stoichiometry:c58 : 1

m19*0.1

nodelay

--

true

0

false

PMID: 17334565 Both pathways are capable of inducing type I IFNs, but the MyD88-IRF7 pathway appears to function only in pDCs while the Trif pathway appears to function in all cell types.

Go back
673.0, 937.0
21.0, 21.0

p19

p21

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e22

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c60 : 1

m23*0.1

nodelay

--

true

0

false

PMID: 17334565 Both pathways are capable of inducing type I IFNs, but the MyD88-IRF7 pathway appears to function only in pDCs while the Trif pathway appears to function in all cell types.

Go back
597.0, 65.0
21.0, 21.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Cell_WithoutCellWall_

--

e10 MO000042126

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m10*m19940*0.1

nodelay

--

true

0

false

PMID: 17336545, 11607032, 11130078,14976261,14976262,15034168 TLR3 recognizes double-stranded RNA (dsRNA), TLR9 recognizes nonmethylated CpG motifs in DNA (CpG DNA), and TLR7 and TLR8 recognize single-stranded RNA (ssRNA)

Go back
821.0, 73.0
21.0, 21.0

p3

p4

cso30:i:ME_Binding

cso30:i:CC_Cell_WithoutCellWall_

--

MO000042007 e10

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m19823*m10*0.1

nodelay

--

true

0

false

PMID: 17336545, 11607032, 11130078,14976261,14976262,15034168 TLR3 recognizes double-stranded RNA (dsRNA), TLR9 recognizes nonmethylated CpG motifs in DNA (CpG DNA), and TLR7 and TLR8 recognize single-stranded RNA (ssRNA)

Go back
350.0, 70.0
19.0, 19.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Cell_WithoutCellWall_

--

e14 MO000019394

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m14*m3961*0.1

nodelay

--

true

0

false

PMID: 17336545 Table 1

Go back
178.0, 70.0
19.0, 19.0

p5

p6

cso30:i:ME_Binding

cso30:i:CC_Cell_WithoutCellWall_

--

e14 MO000019397

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m14*m3964*0.1

nodelay

--

true

0

false

PMID: 17336545 Table 1

Go back
601.0, 485.0
21.0, 21.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Cell_WithoutCellWall_

--

MO000041446 MO000041125

MO000041437

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1

m19314*m18998*0.1

nodelay

--

true

0

false

PMID: 17336545 TLR3 uses the adaptor Trif to activate the transcription factors NF-kappaB and IRF3.

Go back
536.0, 644.0
23.0, 23.0

p8

p8

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell_WithoutCellWall_

--

MO000041437 MO000000058

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1

m19305*m17*0.1

nodelay

--

true

0

false

PMID: 17336545 TLR3 uses the adaptor Trif to activate the transcription factors NF-kappaB and IRF3.

Go back
592.0, 664.0
23.0, 23.0

p8

p9

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell_WithoutCellWall_

--

MO000041437 MO000007694

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1

m19305*m977*0.1

nodelay

--

true

0

false

PMID: 17336545 TLR3 uses the adaptor Trif to activate the transcription factors NF-kappaB and IRF3.

Go back
836.0, 265.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
842.2541450602852, 100.77511991082454

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
738.0, 57.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
796.9463531699773, 94.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
295.0, 80.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
330.0, 96.09531267333584

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
368.0, 89.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
205.0, 80.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
193.29878308453075, 96.66261028176922

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
197.0, 87.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
624.8973855439314, 330.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
853.0, 248.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
570.0, 512.7294278030124

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
622.0, 499.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
565.6131882737792, 535.0

c22

c22

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
315.0, 629.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
409.4173283056703, 665.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
620.3119397250665, 539.0

c25

c25

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
622.5675675675676, 682.5945945945946

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
604.0, 687.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
638.1716000756318, 162.0

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
566.0, 209.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
764.1754418849364, 256.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
575.8632840217354, 176.35204443655223

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
566.0, 204.0

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
773.9684350024883, 153.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
781.0, 159.58976840766354

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
557.0, 214.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
592.4611360597601, 389.8864248990313

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
585.0, 384.0

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
344.8441746598661, 170.0

c37

c37

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
306.0, 472.8939406483124

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
334.0, 465.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
955.7039846776598, 366.3653853714995

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
492.37308300110453, 160.0

c40

c40

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
312.0, 395.5754603881327

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
395.68197558932377, 389.0

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
507.7336418228921, 387.0

c43

c43

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
315.0, 468.51279923897675

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
397.34363635420743, 464.0

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
497.78722919489917, 171.0

c46

c46

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
423.0, 816.7120559573644

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
506.0, 808.0

c48

c48

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
576.5653651303617, 163.0

c49

c49

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
918.0, 372.8211864903555

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
416.0, 485.4641118913987

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
564.0, 478.0

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
651.381886291202, 399.0

c52

c52

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
420.0, 564.4027139079626

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
643.0, 558.0

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
400.0, 783.0

c55

c55

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
545.0, 974.0

c56

c56

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
604.0, 783.0

c57

c57

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
613.0, 954.0

c58

c58

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
687.3592553320611, 821.0

c59

c59

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
750.3693687140673, 360.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
635.7688672693959, 958.0

c60

c60

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
625.6970138105231, 56.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
608.0, 94.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
618.0, 84.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back