Entity
Caspase-1
--
MO000016828
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m1765
10
infinite
0
TRANSPATH | MO000016828 |
--
dsRNA
--
MO000022224
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m119368
10
infinite
0
TRANSPATH | MO000022224 |
--
--
e1
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane
--
--
--
csml-variable:Double
m1
0
infinite
0
--
--
e10
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytosol
--
--
--
csml-variable:Double
m10
0
infinite
0
--
ssRNA
--
e11
cso30:c:RnaOther
cso30:i:CC_Cytosol
--
csml-variable:Double
m11
0
infinite
0
--
ssRNA:TLR7
--
e12
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m12
0
infinite
0
--
ssRNA:TLR8
--
e13
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m13
0
infinite
0
--
DDX58:ssRNA
--
e14
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m14
0
infinite
0
--
DDX58{active}:ssRNA
--
e15
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m15
0
infinite
0
--
V proteins
--
e16
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m16
0
infinite
0
--
MDA5:V proteins
--
e17
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m17
0
infinite
0
--
IAV NS1
--
e18
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m18
0
infinite
0
--
DDX58:IAV NS1
--
e19
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m19
0
infinite
0
--
--
e2
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m2
0
infinite
0
--
IFN
--
e20
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
--
csml-variable:Double
m20
0
infinite
0
--
IFN
--
e21
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m21
0
infinite
0
--
IFN-alpha
--
e23
cso30:c:Protein
cso30:i:CC_Nucleoplasm
--
--
csml-variable:Double
m23
0
infinite
0
--
IFN alpha
--
e24
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
--
csml-variable:Double
m24
0
infinite
0
--
Nalp3
--
e26
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m26
0
infinite
0
--
Caspase-1{active}
--
e27
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m27
10
infinite
0
TRANSPATH | MO000016828 |
--
Poly I:C
--
e28
cso30:c:SmallMolecule
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m28
0
infinite
0
--
--
e3
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
--
csml-variable:Double
m3
0
infinite
0
--
--
e4
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m4
0
infinite
0
--
--
e5
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Endosome
--
--
--
csml-variable:Double
m5
0
infinite
0
--
--
e50
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelopeLumen
--
--
--
csml-variable:Double
m50
0
infinite
0
--
--
e51
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearPore
--
--
--
csml-variable:Double
m51
0
infinite
0
--
--
e52
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearInnerMembrane
--
--
--
csml-variable:Double
m52
0
infinite
0
--
--
e53
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearLumen
--
--
--
csml-variable:Double
m53
0
infinite
0
--
--
e54
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearOuterMembrane
--
--
--
csml-variable:Double
m54
0
infinite
0
--
--
e55
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleus
--
--
--
csml-variable:Double
m55
0
infinite
0
--
--
e56
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleoplasm
--
--
--
csml-variable:Double
m56
0
infinite
0
--
--
e57
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearBody
--
--
--
csml-variable:Double
m57
0
infinite
0
--
--
e58
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleolus
--
--
--
csml-variable:Double
m58
0
infinite
0
--
--
e59
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelope
--
--
--
csml-variable:Double
m59
0
infinite
0
--
--
e6
cso30:c:EntityBiologicalCompartment
cso30:i:CC_EndosomeMembrane
--
--
--
csml-variable:Double
m6
0
infinite
0
--
--
e60
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Chromatin
--
--
--
csml-variable:Double
m60
0
infinite
0
--
--
e61
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearChromosome
--
--
--
csml-variable:Double
m61
0
infinite
0
--
--
e62
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearCentromere
--
--
--
csml-variable:Double
m62
0
infinite
0
--
--
e7
cso30:c:EntityBiologicalCompartment
cso30:i:CC_EndosomeLumen
--
--
--
csml-variable:Double
m7
0
infinite
0
--
eIF-2alpha{p}
--
e8
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m8
0
infinite
0
--
p1
p1
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1
m119368*m1055*0.1
nodelay
--
0
PMID: 17307033,11752661 The first dsRNA-binding protein to be described was PKR (Table 1), a key mediator of the antiviral action of type I interferon (IFN) PMID: 17307033 A pair of dsRNA-binding domains in the N-terminal portion of PKR binds to dsRNA.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c30 : 1
stoichiometry:c29 : 1
m20*0.1
nodelay
--
0
PMID: 17307033,17038589 The Pichlmair study also demonstrated that the IAV NS1 protein, which was thought to block IFN induction by sequestering dsRNA, instead blocks by forming a complex with RIG-I to abrogate RIG-I signaling
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c8 : 1
stoichiometry:c32 : 1
m24*m15*0.1
nodelay
--
0
PMID: 17303033 Therefore, during infection, RIG-I probably mediates local IFNa production, which is crucial for the initial antiviral response, whereas TLR7 controls systemic IFNa levels, as pDCs make a substantial contribution to the total IFNa produced during an infection.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c49 : 1
stoichiometry:c39 : 1
m25*m27*0.1
nodelay
--
0
PMID: 17303033,17008311 An additional antiviral effector mechanism involves the production of the inflammatory cytokines interleukin (IL)-1 and IL-18, which are generated by proteolytic processing of their pro-forms through the action of caspase-1
p13
p13
cso30:i:ME_Processing
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c48 : 1
stoichiometry:c36 : 1
m841*m27*0.1
nodelay
--
0
PMID: 17303033,17008311 An additional antiviral effector mechanism involves the production of the inflammatory cytokines interleukin (IL)-1 and IL-18, which are generated by proteolytic processing of their pro-forms through the action of caspase-1
p14
p14
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1
stoichiometry:c43 : 1
stoichiometry:c42 : 1
m26*m1765*m119368*0.1
nodelay
--
0
PMID: 17307033,17008311 Poly(I:C), viral dsRNA and Sendai virus (SeV) all activated caspase-1 through the nucleotide oligomerization domainlike receptor protein Nalp3 (also known as cryopyrin)
p14
p15
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c45 : 1
stoichiometry:c46 : 1
stoichiometry:c47 : 1
m26*m28*m1765*0.1
nodelay
--
0
PMID: 17307033,17008311 Poly(I:C), viral dsRNA and Sendai virus (SeV) all activated caspase-1 through the nucleotide oligomerization domainlike receptor protein Nalp3 (also known as cryopyrin)
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c21 : 1
stoichiometry:c37 : 1
m14*0.1
nodelay
--
0
PMID: 17307033 Moreover, they found that ssRNA such as that from the influenza virus genome, which is uncapped and has a 50-triphosphate moiety, associated with and activated RIG-I.
p2
p2
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c50 : 1
stoichiometry:c9 : 1
m6843*m6524*0.1
nodelay
--
0
PMID: 17307033 A pair of dsRNA-binding domains in the N-terminal portion of PKR binds to dsRNA. PKR functions to phosphorylate the a subunit of the translation initiation factor eIF2, thereby inhibiting protein synthesisA pair of dsRNA-binding domains in the N-terminal portion of PKR binds to dsRNA. PKR functions to phosphorylate the a subunit of the translation initiation factor eIF2, thereby inhibiting protein synthesis
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1
m119368*m9*0.1
nodelay
--
0
PMID: 17307033,15961631,16043704 The TLR3 ectodomain senses dsRNA both extracellularly and in endosomes, and its structure has been solved recently
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c17 : 1
m11*m19940*0.1
nodelay
--
0
PMID: 17307033 Single-stranded RNA of ssRNA viruses is detected through TLR7 and TLR8, which are located in the endosomal compartment
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c16 : 1
stoichiometry:c18 : 1
m11*m19823*0.1
nodelay
--
0
PMID: 17307033 Single-stranded RNA of ssRNA viruses is detected through TLR7 and TLR8, which are located in the endosomal compartment
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c34 : 1
stoichiometry:c20 : 1
m41844*m11*0.1
nodelay
--
0
PMID: 17307033,17038590 Artificial capping or base modification of this 50-triphosphate (as would occur in host RNA) abolished this response, which they showed was mediated by direct binding to RIG-I PMID: 17307033 Moreover, they found that ssRNA such as that from the influenza virus genome, which is uncapped and has a 50-triphosphate moiety, associated with and activated RIG-I.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1
m76904*m16*0.1
nodelay
--
0
PMID: 17307033,16672351,16625202,16714379 However, a current paradox is that, although negative-stranded paramyxoviruses do not produce detectable amounts of dsRNA, and are detected by RIG-I and not MDA5 their V proteins bind to Mda5 (and not RIG-I) and inhibit downstream signaling
p8
p8
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1
m3965*m119368*0.1
nodelay
--
0
PMID: 17307033,15961631,16043704 The TLR3 ectodomain senses dsRNA both extracellularly and in endosomes, and its structure has been solved recently
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1
m18*m41844*0.1
nodelay
--
0
PMID: 17307033,17038589 The Pichlmair study also demonstrated that the IAV NS1 protein, which was thought to block IFN induction by sequestering dsRNA, instead blocks by forming a complex with RIG-I to abrogate RIG-I signaling
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--