Entity
Process
NF-kappaB
--
MO000000058
cso30:c:Protein
cso30:i:CC_CellComponent
--
--
csml-variable:Double
m69
10
infinite
0
TRANSPATH | MO000000058 |
--
IKK-alpha
--
MO000000210
cso30:c:Protein
cso30:i:CC_CellComponent
--
--
csml-variable:Double
m181
10
infinite
0
InterPro | IPR000719 |
TRANSPATH | MO000000210 |
--
TRAF6
--
MO000000212
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m183
10
infinite
0
InterPro | IPR001841 |
TRANSPATH | MO000000212 |
--
TNF-alpha
--
MO000000289
cso30:c:Protein
cso30:i:CC_CellComponent
--
--
csml-variable:Double
m230
10
infinite
0
InterPro | IPR003636 |
TRANSPATH | MO000000289 |
--
PIP2
--
MO000000331
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m290229
10
infinite
0
TRANSPATH | MO000000331 |
--
Btk
--
MO000001935
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m367
10
infinite
0
InterPro | IPR001452 |
TRANSPATH | MO000001935 |
--
IRF-3
--
MO000007694
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m977
10
infinite
0
InterPro | IPR008984 |
TRANSPATH | MO000007694 |
--
IRF-7
--
MO000007702
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m980
10
infinite
0
TRANSPATH | MO000007702 |
--
MyD88
--
MO000016573
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m1572
10
infinite
0
InterPro | IPR000157 |
TRANSPATH | MO000016573 |
--
IKK-gamma
--
MO000016599
cso30:c:Protein
cso30:i:CC_CellComponent
--
--
csml-variable:Double
m1593
10
infinite
0
InterPro | IPR007087 |
TRANSPATH | MO000016599 |
--
IKK-i
--
MO000016608
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m1599
10
infinite
0
InterPro | IPR000719 |
TRANSPATH | MO000016608 |
--
PKCepsilon
--
MO000016645
cso30:c:Protein
cso30:i:CC_CellComponent
--
--
csml-variable:Double
m1629
10
infinite
0
InterPro | IPR000719 |
TRANSPATH | MO000016645 |
--
IKK-alpha:IKK-beta:IKK-gamma
--
MO000016661
cso30:c:Protein
cso30:i:CC_CellComponent
--
--
csml-variable:Double
m1637
10
infinite
0
TRANSPATH | MO000016661 |
--
IFNgamma
--
MO000016665
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m1639
10
infinite
0
InterPro | IPR002069 |
TRANSPATH | MO000016665 |
--
Caspase-8
--
MO000016900
cso30:c:Protein
cso30:i:CC_CellComponent
--
--
csml-variable:Double
m1815
10
infinite
0
TRANSPATH | MO000016900 |
--
TRAF3
--
MO000016963
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m1872
10
infinite
0
InterPro | IPR001841 |
TRANSPATH | MO000016963 |
--
TRAF4
--
MO000016964
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m1873
10
infinite
0
InterPro | IPR001841 |
TRANSPATH | MO000016964 |
--
integrins
--
MO000017291
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m2142
10
infinite
0
TRANSPATH | MO000017291 |
--
TBK1
--
MO000019331
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m3902
10
infinite
0
InterPro | IPR000719 |
TRANSPATH | MO000019331 |
--
TLR2
--
MO000019397
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m3964
10
infinite
0
InterPro | IPR000157 |
TRANSPATH | MO000019397 |
--
TIRAP
--
MO000022528
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m6810
10
infinite
0
InterPro | IPR000157 |
TRANSPATH | MO000022528 |
--
TRIF
--
MO000041125
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m18998
10
infinite
0
TRANSPATH | MO000041125 |
--
dsRNA:TLR3
--
MO000041446
cso30:c:Complex
cso30:i:CC_CellComponent
--
csml-variable:Double
m19314
10
infinite
0
TRANSPATH | MO000041446 |
--
IRF-3{p}
--
MO000041456
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m19324
10
infinite
0
TRANSPATH | MO000041456 |
--
TLR9
--
MO000042012
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m19828
10
infinite
0
TRANSPATH | MO000042012 |
--
--
e1
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane
--
--
--
csml-variable:Double
m1
0
infinite
0
--
--
e10
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytosol
--
--
--
csml-variable:Double
m10
0
infinite
0
--
MyD88: TRAF6: IRF-5 {p}
--
e100
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m107
0
infinite
0
--
ligand: TLR: MyD88: IRAK-4: IRAK-1: TRAF6: IRF-7 {p}: OPN-i: IKK-alpha: TRAF3
--
e101
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m108
0
infinite
0
--
IRF-7 {nucleus}
--
e103
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m110
10
infinite
0
TRANSPATH | MO000007702 |
--
csml-variable:Double
m111
10
infinite
0
Ensembl | ENSG00000147877 |
HGNC | IFNA7 |
OMIM | 147567 |
Proteome | HumanPSD/IFNA7 |
RefSeq | NM_021057 |
TRANSFAC | G000306 |
Unigene | Hs.282274 |
--
IRF-7 {p}
--
e105
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m112
0
infinite
0
--
ARF6 GTPase
--
e106
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m113
0
infinite
0
--
--
e107
cso30:c:EntityBiologicalCompartment
cso30:i:CC_EndosomeLumen
--
--
--
csml-variable:Double
m114
0
infinite
0
--
--
e108
cso30:c:EntityBiologicalCompartment
cso30:i:CC_EndosomeMembrane
--
--
--
csml-variable:Double
m115
0
infinite
0
--
--
e109
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Endosome
--
--
--
csml-variable:Double
m116
0
infinite
0
--
csml-variable:Double
m117
0
infinite
0
--
ARF6 GTPase {activated}
--
e112
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m119
0
infinite
0
--
CD11b
--
e113
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m120
0
infinite
0
--
LPS: CD14: TLR4: MD-2: TIRAP: MyD88
--
e114
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m121
0
infinite
0
--
PI5K {activated}
--
e115
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m122
0
infinite
0
--
PI5K
--
e116
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m123
0
infinite
0
--
RP105:MD-1
--
e117
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
csml-variable:Double
m124
0
infinite
0
--
RP105: MD-1: MD-2: TLR4
--
e118
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m125
0
infinite
0
--
MD-2: TLR4
--
e119
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
csml-variable:Double
m126
0
infinite
0
--
csml-variable:Double
m12
0
infinite
0
--
csml-variable:Double
m127
0
infinite
0
--
csml-variable:Double
m128
0
infinite
0
--
TLR9: Triad3A
--
e122
cso30:c:Complex
cso30:i:CC_EndosomeLumen
--
csml-variable:Double
m129
0
infinite
0
--
csml-variable:Double
m130
0
infinite
0
--
TLR9 {degraded}
--
e124
cso30:c:EntityBiological
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m131
0
infinite
0
--
TLR4 {degraded}
--
e125
cso30:c:EntityBiological
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m132
0
infinite
0
--
MyD88s
--
e126
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m133
0
infinite
0
--
csml-variable:Double
m134
0
infinite
0
--
TIRAP {p}
--
e128
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m135
0
infinite
0
--
csml-variable:Double
m136
0
infinite
0
--
TLR1:TLR2: CD36
--
e13
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m13
0
infinite
0
--
TIRAP {ub}
--
e130
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m137
0
infinite
0
--
TIRAp {degraded}
--
e131
cso30:c:EntityBiological
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m138
0
infinite
0
--
csml-variable:Double
m139
0
infinite
0
--
TRAF1 {degraded}
--
e133
cso30:c:EntityBiological
cso30:i:CC_Cytosol
--
csml-variable:Double
m140
0
infinite
0
--
TRAF4: TRAF6: TRIF
--
e134
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m141
0
infinite
0
--
ligand: TLR: MyD88: IRAK-4: IRAK-1: TRAF6: OPN-i: IKK-alpha: TRAF3
--
e135
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m142
0
infinite
0
--
T-bet {activated}
--
e136
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m143
10
infinite
0
InterPro | IPR008967 |
TRANSPATH | MO000090987 |
--
IRF-5 {nucleus}
--
e137
cso30:c:Protein
cso30:i:CC_CellComponent
--
--
csml-variable:Double
m144
10
infinite
0
InterPro | IPR008984 |
TRANSPATH | MO000007700 |
--
MyD88: TRAF6
--
e138
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m145
0
infinite
0
--
Pin1: IRF-3 {p339}
--
e139
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m146
0
infinite
0
--
TLR6: TLR2
--
e14
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m14
0
infinite
0
--
IRF-3 {p339}
--
e140
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m147
0
infinite
0
--
csml-variable:Double
m148
0
infinite
0
--
IRF-3 {degraded}
--
e142
cso30:c:EntityBiological
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m149
0
infinite
0
--
MyD88: IRF-4
--
e143
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m150
0
infinite
0
--
TLR6: TLR2: CD36
--
e15
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m15
0
infinite
0
--
triacyl-lipopeptide: TLR1:TLR2: CD36
--
e16
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m16
0
infinite
0
--
triacyl-lipopeptide
--
e17
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m17
0
infinite
0
--
diacyl-lipopeptide
--
e18
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m18
0
infinite
0
--
diacyl-lipopeptide: TLR6: TLR2: CD36
--
e19
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m19
0
infinite
0
--
--
e2
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m2
0
infinite
0
--
TLR1: TLR10
--
e20
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m20
0
infinite
0
--
TLR2: TLR10
--
e21
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m21
0
infinite
0
--
flagellin: TLR5
--
e22
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m22
0
infinite
0
--
profilin-like molecule
--
e23
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m23
0
infinite
0
--
profilin-like molecule: TLR11
--
e24
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m24
0
infinite
0
--
loxoribidine
--
e25
cso30:c:SmallMolecule
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m25
0
infinite
0
--
loxoribidine: TLR7
--
e26
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m26
0
infinite
0
--
csml-variable:Double
m27
0
infinite
0
--
ssRNA: TLR7
--
e28
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m28
0
infinite
0
--
imidazoquinolines
--
e29
cso30:c:SmallMolecule
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m29
0
infinite
0
--
--
e3
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
--
csml-variable:Double
m3
0
infinite
0
--
ssRNA: TLR8
--
e30
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m30
0
infinite
0
--
imidazoquinolines: TLR8
--
e31
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m31
0
infinite
0
--
csml-variable:Double
m32
0
infinite
0
--
CpG DNA: TLR9
--
e33
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m33
0
infinite
0
--
csml-variable:Double
m34
0
infinite
0
--
hemozoin: TLR9
--
e35
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m35
0
infinite
0
--
TLR
--
e37
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m37
0
infinite
0
--
ligand
--
e38
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m38
0
infinite
0
--
ligand: TLR
--
e39
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m39
0
infinite
0
--
--
e4
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m4
0
infinite
0
--
ligand: TLR: MyD88
--
e40
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m40
0
infinite
0
--
ligand: TLR: MyD88: IRAK-4
--
e41
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m41
0
infinite
0
--
ligand: TLR: MyD88: IRAK1
--
e42
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m42
0
infinite
0
--
ligand: TLR: MyD88: IRAK-M
--
e43
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m43
0
infinite
0
--
ligand: TLR: MyD88: IRAK-2
--
e44
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m44
0
infinite
0
--
csml-variable:Double
m45
0
infinite
0
--
ligand: TLR: MyD88: IRAK
--
e46
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m46
0
infinite
0
--
ligand: TLR: MyD88: IRAK {p}
--
e47
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m47
0
infinite
0
--
csml-variable:Double
m48
10
infinite
0
HGNC | UBE2V1 |
OMIM | 602995 |
Proteome | HumanPSD/UBE2V1 |
RefSeq | NM_001032288 |
TRANSPATH | MO000087842 |
Unigene | Hs.420529 |
UniProt | Q13404-1 |
--
csml-variable:Double
m49
0
infinite
0
--
CD14: TLR4: MD-2
--
e5
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m5
0
infinite
0
--
--
e50
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelopeLumen
--
--
--
csml-variable:Double
m50
0
infinite
0
--
--
e51
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearPore
--
--
--
csml-variable:Double
m51
0
infinite
0
--
--
e52
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearInnerMembrane
--
--
--
csml-variable:Double
m52
0
infinite
0
--
--
e53
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearLumen
--
--
--
csml-variable:Double
m53
0
infinite
0
--
--
e54
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearOuterMembrane
--
--
--
csml-variable:Double
m54
0
infinite
0
--
--
e55
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleus
--
--
--
csml-variable:Double
m55
0
infinite
0
--
--
e56
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleoplasm
--
--
--
csml-variable:Double
m56
0
infinite
0
--
--
e57
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearBody
--
--
--
csml-variable:Double
m57
0
infinite
0
--
--
e58
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleolus
--
--
--
csml-variable:Double
m58
0
infinite
0
--
--
e59
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelope
--
--
--
csml-variable:Double
m59
0
infinite
0
--
LPS: CD14: TLR4: MD-2
--
e6
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m6
0
infinite
0
--
--
e60
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Chromatin
--
--
--
csml-variable:Double
m60
0
infinite
0
--
--
e61
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearChromosome
--
--
--
csml-variable:Double
m61
0
infinite
0
--
--
e62
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearCentromere
--
--
--
csml-variable:Double
m62
0
infinite
0
--
IRAK: TRAF6: Ubc13: Uev1A
--
e63
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m63
0
infinite
0
--
IRAK: TRAF6 {ub}: Ubc13: Uev1A: TAK1: TAB1: TAB2: TAB3
--
e64
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m64
0
infinite
0
--
IRAK: TRAF6: Ubc13: Uev1A: TAK1: TAB1: TAB2: TAB3
--
e65
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m65
0
infinite
0
--
IKK-alpha:IKK-beta:IKK-gamma {activated}
--
e66
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m66
10
infinite
0
TRANSPATH | MO000016661 |
--
degraded IkappaB
--
e67
cso30:c:EntityBiological
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m67
0
infinite
0
--
csml-variable:Double
m68
0
infinite
0
--
NF-kappaB {nucleus}
--
e69
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m70
10
infinite
0
TRANSPATH | MO000000058 |
--
--
e7
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell
--
--
--
csml-variable:Double
m7
0
infinite
0
--
MAPKs {activated}
--
e70
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m72
10
infinite
0
TRANSPATH | MO000000077 |
--
IRAK: TRAF6: Ubc13: Uev1A: TAK1{ub}: TAB1: TAB2: TAB3
--
e72
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m74
0
infinite
0
--
IKK-gamma(m.s.){ub}
--
e73
cso30:c:Protein
cso30:i:CC_CellComponent
--
--
csml-variable:Double
m75
10
infinite
0
TRANSPATH | MO000048690 |
--
ABIN2
--
e77
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m83
0
infinite
0
--
diacyl-lipopeptide: TLR6: TLR2: CD36: TIRAP
--
e79
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m85
0
infinite
0
--
--
e8
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell_WithoutCellWall_
--
--
--
csml-variable:Double
m8
0
infinite
0
--
triacyl-lipopeptide: TLR1:TLR2: CD36: TIRAP
--
e80
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m86
0
infinite
0
--
LPS: CD14: TLR4: MD-2: TIRAP
--
e81
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m87
0
infinite
0
--
dsRNA:TLR3: TRIF
--
e82
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
csml-variable:Double
m88
0
infinite
0
--
LPS: CD14: TLR4: MD-2: TRIF
--
e83
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m89
0
infinite
0
--
dsRNA:TLR3: TRIF: TBK1: IKK-i
--
e84
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m90
0
infinite
0
--
LPS: CD14: TLR4: MD-2: TRIF: TBK1: IKK-i
--
e85
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m91
0
infinite
0
--
IRF-3{p}: IRF-3
--
e86
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m92
0
infinite
0
--
IRF-3{p}: IRF-3 {nucleus}
--
e87
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m93
0
infinite
0
--
csml-variable:Double
m94
0
infinite
0
--
csml-variable:Double
m95
0
infinite
0
--
--
e9
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytoplasm
--
--
--
csml-variable:Double
m9
0
infinite
0
--
NF-kappaB {activated}
--
e90
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m96
10
infinite
0
TRANSPATH | MO000000058 |
--
TRIF: TRAF6: RIP1
--
e91
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m98
0
infinite
0
--
ligand: TLR: MyD88: IRAK-4: IRAK-1: TRAF6: IRF-7
--
e92
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m99
0
infinite
0
--
ligand: TLR: MyD88: IRAK-4: IRAK-1: TRAF6: IRF-7 {p}
--
e93
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m100
0
infinite
0
--
OPN-i
--
e94
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m101
0
infinite
0
--
IL-12 p35
--
e95
cso30:c:mRNA
cso30:i:CC_Nucleolus
--
--
csml-variable:Double
m102
0
infinite
0
--
NOS
--
e96
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
--
csml-variable:Double
m103
0
infinite
0
--
MyD88: IRF1
--
e97
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m104
0
infinite
0
--
IRF-1 {nucleus}
--
e98
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m105
10
infinite
0
InterPro | IPR001346 |
TRANSPATH | MO000007685 |
--
csml-variable:Double
m106
0
infinite
0
--
p1
p1
cso30:i:ME_Binding
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1
stoichiometry:c4 : 1
m2828*m6438*m3961*0.1
nodelay
--
0
PMID: 17275323, 16497588 TLR4, together with its extracellular components such as MD-2 and CD14, recognizes lipopolysaccharide (LPS) from Gram-negative bacteria, which causes septic shock.
p10
p10
cso30:i:ME_Binding
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c30 : 1
stoichiometry:c31 : 1
m3964*m19942*0.1
nodelay
--
0
PMID: 17275323, 16497588 In addition, human TLR10 is thought to heterodimerize with TLR2 and TLR1, although a ligand for these heterodimers remains unknown.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c293 : 1
stoichiometry:c294 : 1
stoichiometry:c295 : 1
m1572*m133*0.1
nodelay
--
0
PMID: 17275323 MyD88s forms a heterodimer with MyD88.
p101
p101
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c296 : 1
stoichiometry:c297 : 1
stoichiometry:c300 : 1
stoichiometry:c298 : 1
m6810*m367*m19*0.1
nodelay
--
0
PMID: 17275323, 16415872 TIRAP is phosphorylated by a tyrosine kinase, Btk, in response to TLR2 and TLR4 ligands, and interacts with SOCS1, which subsequently targets TIRAP for ubiquitination and degradation.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c302 : 1
stoichiometry:c303 : 1
stoichiometry:c304 : 1
m135*m1906*0.1
nodelay
--
0
PMID: 17275323, 16415872 TIRAP is phosphorylated by a tyrosine kinase, Btk, in response to TLR2 and TLR4 ligands, and interacts with SOCS1, which subsequently targets TIRAP for ubiquitination and degradation.
p103
p103
cso30:i:ME_Ubiquitination
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c305 : 1
stoichiometry:c306 : 1
stoichiometry:c307 : 1
m136*0.1
nodelay
--
0
PMID: 17275323, 16415872 TIRAP is phosphorylated by a tyrosine kinase, Btk, in response to TLR2 and TLR4 ligands, and interacts with SOCS1, which subsequently targets TIRAP for ubiquitination and degradation.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c308 : 1
stoichiometry:c309 : 1
m137*0.1
nodelay
--
0
PMID: 17275323, 16415872 TIRAP is phosphorylated by a tyrosine kinase, Btk, in response to TLR2 and TLR4 ligands, and interacts with SOCS1, which subsequently targets TIRAP for ubiquitination and degradation.
p105
p105
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c310 : 1
stoichiometry:c311 : 1
stoichiometry:c312 : 1
m18998*m1871*0.1
nodelay
--
0
PMID: 17275323, 16323247 TRAF1 interacts with TRIF and overexpression of TRIF causes Caspase 8-dependent cleavage of TRAF1.
p106
p106
cso30:i:ME_UnknownDegradation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c313 : 1
stoichiometry:c316 : 1
stoichiometry:c314 : 1
stoichiometry:c315 : 1
m139*m1815*0.1
nodelay
--
0
PMID: 17275323, 16323247 TRAF1 interacts with TRIF and overexpression of TRIF causes Caspase 8-dependent cleavage of TRAF1.
p107
p107
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c319 : 1
stoichiometry:c320 : 1
stoichiometry:c321 : 1
stoichiometry:c322 : 1
m1873*m183*m18998*0.1
nodelay
--
0
PMID: 17275323, 16052631 TRAF4 interacts with TRIF and TRAF6, and its overexpression results in inhibition of NF-kappaB activation induced by TRIF and TRAF6.
p108
p108
cso30:i:ME_Translocation
cso30:i:CC_NuclearEnvelopeLumen
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c324 : 1
stoichiometry:c325 : 1
stoichiometry:c326 : 1
m108*0.1
nodelay
--
0
PMID: 17275323 In this complex, IRF7 is directly phosphorylated by IRAK1, and then translocated to the nucleus to induce expression of type I IFN and IFN-inducible genes.
p109
p109
cso30:i:ME_UnknownActivation
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c327 : 1
stoichiometry:c331 : 1
stoichiometry:c328 : 1
m64461*m33*0.1
nodelay
--
0
PMID: 17275323 In pDC, OPN expression is upregulated by TLR9 ligand through T-bet, a master transcription factor driving Th1 differentiation.
p11
p11
cso30:i:ME_Binding
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1
stoichiometry:c33 : 1
stoichiometry:c34 : 1
m3966*m6485*0.1
nodelay
--
0
PMID: 17275323, 16497588, 16829963 TLR5 is expressed abundantly in intestinal CD11c-positive lamina propria cells where it senses bacterial flagellin.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c329 : 1
stoichiometry:c330 : 1
m143*0.1
nodelay
--
0
PMID: 17275323 In pDC, OPN expression is upregulated by TLR9 ligand through T-bet, a master transcription factor driving Th1 differentiation.
p111
p111
cso30:i:ME_Translocation
cso30:i:CC_NuclearOuterMembrane
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c332 : 1
stoichiometry:c333 : 1
stoichiometry:c334 : 1
m104*0.1
nodelay
--
0
PMID: 17275323 IRF1 is recruited to MyD88 when it is induced by IFNgamma stimulation, and translocates into the nucleus in response to TLR stimulation to induce a set of genes including IFNbeta in conventional DC.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c335 : 1
stoichiometry:c336 : 1
stoichiometry:c337 : 1
m107*0.1
nodelay
--
0
PMID: 17275323 IRF5 binds MyD88 and TRAF6 and moves to the nucleus after phosphorylation.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c341 : 1
stoichiometry:c343 : 1
stoichiometry:c344 : 1
m2065*m147*0.1
nodelay
--
0
PMID: 17275323 The cytoplasmic peptidyl-prolyl-isomerase Pin1, which catalyzes the cis-trans isomerization of peptide-bonds located N-terminal to proline to modulate substrate function, binds IRF3 when it is phosphorylated at Ser339, triggering ubiquitination and subsequent degradation of IRF3 by a proteasome-dependent pathway to terminate IFN responses.
p114
p114
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c340 : 1
stoichiometry:c342 : 1
m977*0.1
nodelay
--
0
PMID: 17275323 The cytoplasmic peptidyl-prolyl-isomerase Pin1, which catalyzes the cis-trans isomerization of peptide-bonds located N-terminal to proline to modulate substrate function, binds IRF3 when it is phosphorylated at Ser339, triggering ubiquitination and subsequent degradation of IRF3 by a proteasome-dependent pathway to terminate IFN responses.
p115
p115
cso30:i:ME_Ubiquitination
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c360 : 1
stoichiometry:c345 : 1
stoichiometry:c346 : 1
m146*0.1
nodelay
--
0
PMID: 17275323 The cytoplasmic peptidyl-prolyl-isomerase Pin1, which catalyzes the cis-trans isomerization of peptide-bonds located N-terminal to proline to modulate substrate function, binds IRF3 when it is phosphorylated at Ser339, triggering ubiquitination and subsequent degradation of IRF3 by a proteasome-dependent pathway to terminate IFN responses.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c347 : 1
stoichiometry:c348 : 1
m148*0.1
nodelay
--
0
PMID: 17275323 The cytoplasmic peptidyl-prolyl-isomerase Pin1, which catalyzes the cis-trans isomerization of peptide-bonds located N-terminal to proline to modulate substrate function, binds IRF3 when it is phosphorylated at Ser339, triggering ubiquitination and subsequent degradation of IRF3 by a proteasome-dependent pathway to terminate IFN responses.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c350 : 1
stoichiometry:c349 : 1
m6*0.1
nodelay
--
0
PMID: 17275323 LPS stimulation leads to the expression of ATF3, a member of the ATF/CREB family of transcription factors.
p118
p118
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c351 : 1
stoichiometry:c352 : 1
stoichiometry:c353 : 1
m1572*m978*0.1
nodelay
--
0
PMID: 17275323, 16236719 IRF4 is reported to bind MyD88.
p101
p119
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c356 : 1
stoichiometry:c357 : 1
stoichiometry:c299 : 1
stoichiometry:c301 : 1
m367*m86*m6810*0.1
nodelay
--
0
PMID: 17275323, 16415872 TIRAP is phosphorylated by a tyrosine kinase, Btk, in response to TLR2 and TLR4 ligands, and interacts with SOCS1, which subsequently targets TIRAP for ubiquitination and degradation.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c36 : 1
stoichiometry:c37 : 1
m23*m19944*0.1
nodelay
--
0
PMID: 17275323 Mouse TLR11 recognizes as yet unknown components of uropathogenic bacteria, and a profilin-like molecule of the protozoan parasite Toxoplasma gondii.
p101
p120
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c64 : 1
stoichiometry:c355 : 1
stoichiometry:c358 : 1
stoichiometry:c359 : 1
m367*m121*m6810*0.1
nodelay
--
0
PMID: 17275323, 16415872 TIRAP is phosphorylated by a tyrosine kinase, Btk, in response to TLR2 and TLR4 ligands, and interacts with SOCS1, which subsequently targets TIRAP for ubiquitination and degradation.
p87
p121
cso30:i:ME_UnknownProduction
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c362 : 1
stoichiometry:c363 : 1
m120*0.1
nodelay
--
0
PMID: 17275323 Integrin signaling regulates the production of PIP2 through the activation of ARF6 GTPase and PI5K.
p87
p122
cso30:i:ME_UnknownProduction
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c255 : 1
stoichiometry:c364 : 1
m119*0.1
nodelay
--
0
PMID: 17275323 Integrin signaling regulates the production of PIP2 through the activation of ARF6 GTPase and PI5K.
p13
p13
cso30:i:ME_Binding
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c39 : 1
stoichiometry:c40 : 1
m3965*m119368*0.1
nodelay
--
0
PMID: 17275323 TLR3 was shown to recognize double stranded RNA (dsRNA), which is produced by many viruses during replication.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c41 : 1
stoichiometry:c42 : 1
stoichiometry:c43 : 1
m25*m19940*0.1
nodelay
--
0
PMID: 17275323, 16497588 TLR7 recognizes synthetic imidazoquinoline-like molecules, guanosine analogs such as loxoribine, single stranded RNA (ssRNA) derived from various viruses and small interfering RNA.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c45 : 1
stoichiometry:c46 : 1
m19940*m27*0.1
nodelay
--
0
PMID: 17275323, 16497588 TLR7 recognizes synthetic imidazoquinoline-like molecules, guanosine analogs such as loxoribine, single stranded RNA (ssRNA) derived from various viruses and small interfering RNA.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c48 : 1
stoichiometry:c49 : 1
m19823*m27*0.1
nodelay
--
0
PMID: 17275323 Human TLR8, which has the highest homology to TLR7, participates in the recognition of imidazoquinolines and ssRNA.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c51 : 1
stoichiometry:c52 : 1
m19823*m29*0.1
nodelay
--
0
PMID: 17275323 Human TLR8, which has the highest homology to TLR7, participates in the recognition of imidazoquinolines and ssRNA.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c53 : 1
stoichiometry:c54 : 1
stoichiometry:c55 : 1
m19828*m32*0.1
nodelay
--
0
PMID: 17275323, 16497588 TLR9 recognizes CpG DNA motifs present in bacterial and viral genomes as well as non-nucleic acids such as hemozoin from the malaria parasite.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c57 : 1
stoichiometry:c58 : 1
m19828*m34*0.1
nodelay
--
0
PMID: 17275323, 16497588 TLR9 recognizes CpG DNA motifs present in bacterial and viral genomes as well as non-nucleic acids such as hemozoin from the malaria parasite.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c5 : 1
stoichiometry:c6 : 1
stoichiometry:c274 : 1
stoichiometry:c7 : 1
m155666*m5*0.1
nodelay
--
0
PMID: 17275323, 16497588 TLR4, together with its extracellular components such as MD-2 and CD14, recognizes lipopolysaccharide (LPS) from Gram-negative bacteria, which causes septic shock. PMID: 17275323, 9686597 the RP105-MD-1 complex interacts with a TLR4-MD-2 complex to prevent LPS binding to TLR4-MD-2.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c60 : 1
stoichiometry:c61 : 1
m38*m37*0.1
nodelay
--
0
PMID: 17275323 Following stimulation, all TLRs except for TLR3 recruit MyD88, IRAKs and TRAF6 to activate the Ubc13/TAK1 pathway.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1
stoichiometry:c63 : 1
stoichiometry:c65 : 1
m39*m1572*0.1
nodelay
--
0
PMID: 17275323 Following stimulation, all TLRs except for TLR3 recruit MyD88, IRAKs and TRAF6 to activate the Ubc13/TAK1 pathway.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c66 : 1
stoichiometry:c78 : 1
stoichiometry:c68 : 1
m40*m17258*0.1
nodelay
--
0
PMID: 17275323 The association of TLRs and MyD88 stimulates the recruitment of members of the IRAK family, including IRAK1, IRAK2, IRAK4 and IRAK-M.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c70 : 1
stoichiometry:c71 : 1
m40*m36*0.1
nodelay
--
0
PMID: 17275323 The association of TLRs and MyD88 stimulates the recruitment of members of the IRAK family, including IRAK1, IRAK2, IRAK4 and IRAK-M.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c73 : 1
stoichiometry:c74 : 1
m40*m1571*0.1
nodelay
--
0
PMID: 17275323 The association of TLRs and MyD88 stimulates the recruitment of members of the IRAK family, including IRAK1, IRAK2, IRAK4 and IRAK-M.
p25
p25
cso30:i:ME_Binding
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c75 : 1
stoichiometry:c76 : 1
stoichiometry:c77 : 1
m40*m1569*0.1
nodelay
--
0
PMID: 17275323 The association of TLRs and MyD88 stimulates the recruitment of members of the IRAK family, including IRAK1, IRAK2, IRAK4 and IRAK-M.
p26
p26
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c88 : 1
stoichiometry:c338 : 1
stoichiometry:c84 : 1
m183*m49*0.1
nodelay
--
0
PMID: 17275323 Once phosphorylated, IRAKs dissociate from MyD88 and interact with TRAF6, a member of the TRAF family. PMID: 17275323 TRAF4 may serve to antagonize TRAF6 function by preventing recruitment of TRAF6 to the adapter complex.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c80 : 1
stoichiometry:c81 : 1
m40*m6176*0.1
nodelay
--
0
PMID: 17275323 Once phosphorylated, IRAKs dissociate from MyD88 and interact with TRAF6, a member of the TRAF family.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c82 : 1
m46*0.1
nodelay
--
0
PMID: 17275323 Once phosphorylated, IRAKs dissociate from MyD88 and interact with TRAF6, a member of the TRAF family.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c85 : 1
stoichiometry:c86 : 1
stoichiometry:c87 : 1
m47*0.1
nodelay
--
0
PMID: 17275323 Once phosphorylated, IRAKs dissociate from MyD88 and interact with TRAF6, a member of the TRAF family.
p3
p3
cso30:i:ME_Binding
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c8 : 1
stoichiometry:c9 : 1
stoichiometry:c10 : 1
m3963*m3964*0.1
nodelay
--
0
PMID: 17275323, 16497588 TLR2 forms heterodimers with TLR1, TLR6 and non-TLRs such as CD36 to discriminate a wide variety of PAMPs, including peptidoglycan, lipopeptides and lipoproteins of Gram-positive bacteria, mycoplasma lipopeptides and fungal zymosan.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c89 : 1
stoichiometry:c90 : 1
stoichiometry:c91 : 1
stoichiometry:c92 : 1
m6443*m48*m45*0.1
nodelay
--
0
PMID; 17275323, 16056267 TRAF6, an E3 ligase, forms a complex with Ubc13 and Uev1A to promote the synthesis of lysine 63-linked polyubiquitin chains, which in turn activate TAK1, a MAPKKK.
p31
p31
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c101 : 1
stoichiometry:c103 : 1
stoichiometry:c102 : 1
m1637*m74*0.1
nodelay
--
0
PMID: 17275323 TAK1, in combination with TAB1, TAB2 and TAB3, activates two downstream pathways involving the IKK complex and the MAPK family.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c339 : 1
stoichiometry:c100 : 1
m65*0.1
nodelay
--
0
PMID; 17275323, 16056267 TRAF6, an E3 ligase, forms a complex with Ubc13 and Uev1A to promote the synthesis of lysine 63-linked polyubiquitin chains, which in turn activate TAK1, a MAPKKK. PMID: 17275323, 16862162 Although in vitro analyses have implicated Ubc13 in the activation of NF-kappaB and MAPK, via ubiquitination of TAK1, studies on mice with a conditionally deleted Ubc13 gene in various tissues have shown that it has a dispensable role in NF-kappaB activation. PMID: 17275323, 15334086 A20, an inducible de-ubiqutination enzyme, removes ubiquitin moieties from TRAF6 to terminate TLR signaling.
p33
p33
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c97 : 1
stoichiometry:c94 : 1
stoichiometry:c95 : 1
stoichiometry:c96 : 1
stoichiometry:c98 : 1
m63*m1573*m1583*m6433*m19389*0.1
nodelay
--
0
PMID: 17275323 TAK1, in combination with TAB1, TAB2 and TAB3, activates two downstream pathways involving the IKK complex and the MAPK family.
p34
p34
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c104 : 1
stoichiometry:c105 : 1
stoichiometry:c106 : 1
m66*m186*0.1
nodelay
--
0
PMID: 17275323 The IKK complex, composed of the catalytic subunits IKKalpha and IKKbeta and a regulatory subunit IKKgamma/NEMO, catalyzes the phosphorylation of IkappaB proteins.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c107 : 1
stoichiometry:c108 : 1
stoichiometry:c109 : 1
m68*0.1
nodelay
--
0
PMID: 17275323 Phosphorylated IkappaB proteins are degraded by a proteasome-dependent pathway, allowing NF-kappaB to translocate to the nucleus.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c189 : 1
stoichiometry:c111 : 1
m96*0.1
nodelay
--
0
PMID: 17275323 Phosphorylated IkappaB proteins are degraded by a proteasome-dependent pathway, allowing NF-kappaB to translocate to the nucleus.
p37
p37
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c112 : 1
stoichiometry:c119 : 1
stoichiometry:c113 : 1
m71*m74*0.1
nodelay
--
0
PMID: 17275323 TAK1 also activates the MAPK pathway, which mediates AP-1 activation.
p38
p38
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c115 : 1
stoichiometry:c117 : 1
stoichiometry:c116 : 1
m219*m72*0.1
nodelay
--
0
PMID: 17275323 TAK1 also activates the MAPK pathway, which mediates AP-1 activation.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c114 : 1
stoichiometry:c118 : 1
m64*0.1
nodelay
--
0
PMID: 17275323, 16862162 Although in vitro analyses have implicated Ubc13 in the activation of NF-kappaB and MAPK, via ubiquitination of TAK1, studies on mice with a conditionally deleted Ubc13 gene in various tissues have shown that it has a dispensable role in NF-kappaB activation.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c11 : 1
stoichiometry:c12 : 1
stoichiometry:c13 : 1
m11*m12*0.1
nodelay
--
0
PMID: 17275323, 16497588 TLR2 forms heterodimers with TLR1, TLR6 and non-TLRs such as CD36 to discriminate a wide variety of PAMPs, including peptidoglycan, lipopeptides and lipoproteins of Gram-positive bacteria, mycoplasma lipopeptides and fungal zymosan.
p40
p40
cso30:i:ME_Ubiquitination
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c120 : 1
stoichiometry:c122 : 1
stoichiometry:c121 : 1
m1593*m6443*0.1
nodelay
--
0
PMID: 17275323, 16862162 Notably, in Ubc13-deficient cells, there is a reduction in the stimulus-dependent ubiquitination of IKKgamma/NEMO, suggesting a link between Ubc13-dependent IKKgamma/NEMO ubiquitination and MAPK activation.
p41
p41
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c123 : 1
stoichiometry:c125 : 1
stoichiometry:c137 : 1
stoichiometry:c138 : 1
stoichiometry:c124 : 1
m76*m6*m82*m83*0.1
nodelay
--
0
PMID: 17275323, 11163183 LPS-stimulated ERKactivation and TNFalpha production is severely impaired in Tpl2-deficient macrophages, whereas activation of JNK and p38 is normal. PMID: 17275323, 16633345 It has been reported that ABIN2 (A20-binding inhibitor of NF-kappaB 2) increases the stability of Tpl2 to facilitate ERK activation.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c126 : 1
stoichiometry:c128 : 1
m6*0.1
nodelay
--
0
PMID: 17275323, 11163183 LPS-stimulated ERKactivation and TNFalpha production is severely impaired in Tpl2-deficient macrophages, whereas activation of JNK and p38 is normal.
p43
p43
cso30:i:ME_Translation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c127 : 1
stoichiometry:c130 : 1
stoichiometry:c129 : 1
m6*m93309*0.1
nodelay
--
0
PMID: 17275323, 11163183 LPS-stimulated ERKactivation and TNFalpha production is severely impaired in Tpl2-deficient macrophages, whereas activation of JNK and p38 is normal.
p44
p44
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c131 : 1
stoichiometry:c133 : 1
stoichiometry:c132 : 1
m78*m6*0.1
nodelay
--
0
PMID: 17275323, 11163183 LPS-stimulated ERKactivation and TNFalpha production is severely impaired in Tpl2-deficient macrophages, whereas activation of JNK and p38 is normal.
p45
p45
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c134 : 1
stoichiometry:c135 : 1
stoichiometry:c136 : 1
m6*m80*0.1
nodelay
--
0
PMID: 17275323, 11163183 LPS-stimulated ERKactivation and TNFalpha production is severely impaired in Tpl2-deficient macrophages, whereas activation of JNK and p38 is normal.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c139 : 1
stoichiometry:c140 : 1
m6*0.1
nodelay
--
0
PMID: 17275323, 14661019 Macrophages deficient for MEKK3 show defective JNK and p38 activation and IL-6 production after LPS treatment.
p47
p47
cso30:i:ME_Translation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c142 : 1
stoichiometry:c143 : 1
stoichiometry:c141 : 1
m93248*m6*0.1
nodelay
--
0
PMID: 17275323, 14661019 Macrophages deficient for MEKK3 show defective JNK and p38 activation and IL-6 production after LPS treatment.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c144 : 1
stoichiometry:c146 : 1
m6*0.1
nodelay
--
0
PMID: 17275323 LPS-induced ROS production is implicated in facilitating the TRAF6-ASK1-p38 signaling axis.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c145 : 1
stoichiometry:c148 : 1
stoichiometry:c147 : 1
m6*m84*0.1
nodelay
--
0
p5
p5
cso30:i:ME_Binding
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c14 : 1
stoichiometry:c15 : 1
stoichiometry:c16 : 1
m3987*m3964*0.1
nodelay
--
0
PMID: 17275323, 16497588 TLR2 forms heterodimers with TLR1, TLR6 and non-TLRs such as CD36 to discriminate a wide variety of PAMPs, including peptidoglycan, lipopeptides and lipoproteins of Gram-positive bacteria, mycoplasma lipopeptides and fungal zymosan.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c151 : 1
stoichiometry:c152 : 1
stoichiometry:c154 : 1
m6810*m16*0.1
nodelay
--
0
PMID: 17275323 TIRAP is recruited to TLR4, TLR1/2 and TLR2/6, activating the MyD88-dependent pathway.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c149 : 1
stoichiometry:c150 : 1
stoichiometry:c153 : 1
m19*m6810*0.1
nodelay
--
0
PMID: 17275323 TIRAP is recruited to TLR4, TLR1/2 and TLR2/6, activating the MyD88-dependent pathway.
p52
p52
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c155 : 1
stoichiometry:c156 : 1
stoichiometry:c259 : 1
stoichiometry:c276 : 1
stoichiometry:c157 : 1
m6810*m6*m290229*0.1
nodelay
--
0
PMID: 17275323 TIRAP is recruited to TLR4, TLR1/2 and TLR2/6, activating the MyD88-dependent pathway. PMID: 17275323 These findings suggest that TLR4 recruits TIRAP to the plasma membrane as a result of CD11b-mediated production of PIP2, which subsequently recruits MyD88 after which the signaling complex is assembled to initiate the MyD88-dependent signaling. PMID: 17275323 ST2L sequesters MyD88 and TIRAP to inhibit the recruitment of these adapters to TLR4.
p53
p53
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c158 : 1
stoichiometry:c159 : 1
stoichiometry:c160 : 1
m19314*m18998*0.1
nodelay
--
0
PMID: 17275323 TRIF is recruited to TLR3 and TLR4, and interacts with TBK1 and IKKi, which mediate phosphorylation of IRF3.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c161 : 1
stoichiometry:c162 : 1
stoichiometry:c163 : 1
m6*m18998*0.1
nodelay
--
0
PMID: 17275323 TRIF is recruited to TLR3 and TLR4, and interacts with TBK1 and IKKi, which mediate phosphorylation of IRF3.
p55
p55
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c164 : 1
stoichiometry:c165 : 1
stoichiometry:c166 : 1
stoichiometry:c167 : 1
m3902*m1599*m88*0.1
nodelay
--
0
PMID: 17275323 TRIF is recruited to TLR3 and TLR4, and interacts with TBK1 and IKKi, which mediate phosphorylation of IRF3.
p56
p56
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c169 : 1
stoichiometry:c170 : 1
stoichiometry:c168 : 1
m3902*m1599*0.1
nodelay
--
0
PMID: 17275323 TRIF is recruited to TLR3 and TLR4, and interacts with TBK1 and IKKi, which mediate phosphorylation of IRF3.
p57
p57
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c171 : 1
stoichiometry:c174 : 1
stoichiometry:c172 : 1
m977*m91*0.1
nodelay
--
0
PMID: 17275323 TRIF is recruited to TLR3 and TLR4, and interacts with TBK1 and IKKi, which mediate phosphorylation of IRF3.
p58
p58
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c175 : 1
stoichiometry:c173 : 1
stoichiometry:c318 : 1
stoichiometry:c176 : 1
m977*m90*0.1
nodelay
--
0
PMID: 17275323 TRIF is recruited to TLR3 and TLR4, and interacts with TBK1 and IKKi, which mediate phosphorylation of IRF3. PMID: 17275323 The cleaved fragment of TRAF1 can inhibit TRIF-dependent activation of NF-kappaB and IRF3, suggesting that TRIF-induced cleavage of TRAF1 is responsible for shutdown of the TRIFdependent pathway.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c177 : 1
stoichiometry:c178 : 1
m19324*0.1
nodelay
--
0
PMID: 17275323 Phosphorylated IRF3 dimerizes and is translocated to the nucleus to induce expression of type I IFN and IFN-inducible genes.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c17 : 1
stoichiometry:c18 : 1
stoichiometry:c19 : 1
m12*m14*0.1
nodelay
--
0
PMID: 17275323, 16497588 TLR2 forms heterodimers with TLR1, TLR6 and non-TLRs such as CD36 to discriminate a wide variety of PAMPs, including peptidoglycan, lipopeptides and lipoproteins of Gram-positive bacteria, mycoplasma lipopeptides and fungal zymosan.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c179 : 1
stoichiometry:c180 : 1
m92*0.1
nodelay
--
0
PMID: 17275323 Phosphorylated IRF3 dimerizes and is translocated to the nucleus to induce expression of type I IFN and IFN-inducible genes.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c181 : 1
stoichiometry:c182 : 1
m93*0.1
nodelay
--
0
PMID: 17275323 Phosphorylated IRF3 dimerizes and is translocated to the nucleus to induce expression of type I IFN and IFN-inducible genes.
p62
p62
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c183 : 1
stoichiometry:c184 : 1
stoichiometry:c185 : 1
stoichiometry:c186 : 1
m1599*m3902*m1872*0.1
nodelay
--
0
PMID: 17275323 TRAF3 forms a complex with TBK1 and IKKi.
p63
p63
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c188 : 1
stoichiometry:c187 : 1
stoichiometry:c208 : 1
stoichiometry:c192 : 1
m183*m18998*m109*0.1
nodelay
--
0
PMID: 17275323, 16115877 RIP1 is reportedly polyubiquitinated and forms a complex with TRAF6 and TAK1.
p64
p64
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c110 : 1
stoichiometry:c193 : 1
stoichiometry:c317 : 1
stoichiometry:c323 : 1
stoichiometry:c190 : 1
m69*m98*0.1
nodelay
--
0
PMID: 17275323 TRIF interacts with TRAF6 and RIP1, which mediate NF-kappaB activation. PMID: 17275323 The cleaved fragment of TRAF1 can inhibit TRIF-dependent activation of NF-kappaB and IRF3, suggesting that TRIF-induced cleavage of TRAF1 is responsible for shutdown of the TRIFdependent pathway. PMID: 17275323, 16052631 TRAF4 interacts with TRIF and TRAF6, and its overexpression results in inhibition of NF-kappaB activation induced by TRIF and TRAF6.
p65
p65
cso30:i:ME_Binding
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c194 : 1
stoichiometry:c195 : 1
stoichiometry:c196 : 1
stoichiometry:c197 : 1
stoichiometry:c198 : 1
m41*m36*m183*m980*0.1
nodelay
--
0
PMID: 17275323 In pDC, a signaling complex consisting of MyD88-TRAF6-IRAK4-IRAK1-IRF7 is formed.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c199 : 1
stoichiometry:c200 : 1
m99*0.1
nodelay
--
0
PMID: 17275323 In this complex, IRF7 is directly phosphorylated by IRAK1, and then translocated to the nucleus to induce expression of type I IFN and IFN-inducible genes.
p67
p67
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c201 : 1
stoichiometry:c202 : 1
stoichiometry:c203 : 1
stoichiometry:c226 : 1
stoichiometry:c204 : 1
m1872*m101*m181*m100*0.1
nodelay
--
0
PMID: 17275323 OPN-i, TRAF3 and IKKalpha are also involved in this complex.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c205 : 1
stoichiometry:c206 : 1
m93*0.1
nodelay
--
0
PMID: 17275223 Phosphorylated IRF3 forms a dimer, which translocates from cytoplasm to the nucleus to induce expression of target genes including IFNbeta.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c191 : 1
stoichiometry:c207 : 1
m97*0.1
nodelay
--
0
PMID: 17275323, 16115877 RIP1 is reportedly polyubiquitinated and forms a complex with TRAF6 and TAK1.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c20 : 1
stoichiometry:c21 : 1
stoichiometry:c22 : 1
m13*m17*0.1
nodelay
--
0
PMID: 17275323, 16497588 In particular, TLR1/2 and TLR2/6 can discriminate triacyl- and diacyl-lipopeptide, respectively.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c209 : 1
stoichiometry:c210 : 1
m110*0.1
nodelay
--
0
PMID: 17275323 IRF7 potently activates the promoter of IFNbeta and various IFNalpha genes.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c212 : 1
stoichiometry:c211 : 1
m110*0.1
nodelay
--
0
PMID: 17275323 IRF7 potently activates the promoter of IFNbeta and various IFNalpha genes.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c214 : 1
stoichiometry:c213 : 1
m33*0.1
nodelay
--
0
PMID: 17275323, 12356687, 12626561 Notably, TLR7- and TLR9-mediated type I IFN induction is elicited by the MyD88-dependent pathway, but not by the TRIF-dependent pathway.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c215 : 1
stoichiometry:c216 : 1
m28*0.1
nodelay
--
0
PMID: 17275323, 12356687, 12626561 Notably, TLR7- and TLR9-mediated type I IFN induction is elicited by the MyD88-dependent pathway, but not by the TRIF-dependent pathway.
p74
p74
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c217 : 1
stoichiometry:c219 : 1
stoichiometry:c218 : 1
m980*m95*0.1
nodelay
--
0
PMID: 17275323 TRAF3 is also required for TBK1/IKKi-dependent IRF7 and IRF3 activation in TLR3 and RIG-I/Mda5-signaling.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c221 : 1
stoichiometry:c220 : 1
m112*0.1
nodelay
--
0
PMID: 17275323 IRF7 also participates in type I IFN induction activated by the cytosolic RNA helicases RIG-I and Mda5, which recognize viral dsRNA, in conventional DC, macrophages and fibroblast cells.
p76
p76
cso30:i:ME_GeneExpression
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c222 : 1
stoichiometry:c223 : 1
m1872*0.1
nodelay
--
0
PMID: 17275323 TRAF3 is also necessary for the induction of anti-inflammatory cytokine IL- 10, but not pro-inflammatory cytokines, in response to ligands specific for TLR3, 4, 7 and 9.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c225 : 1
stoichiometry:c224 : 1
m70*0.1
nodelay
--
0
PMID: 17275323, 16604075 pDC isolated from either T-bet- or OPN deficient mice have defects in the induction of type I IFN in response to TLR9-ligand, but they can produce NF-kappaB-driven IL-6 as usual.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c229 : 1
stoichiometry:c227 : 1
m33*0.1
nodelay
--
0
PMID: 17275323 Conventional DC derived from IRF1-deficient mice display impaired induction of IFNbeta, inducible nitric-oxide synthase and IL-12 p35, in response to a TLR9 ligand.
p79
p79
cso30:i:ME_GeneExpression
cso30:i:CC_NuclearOuterMembrane
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c230 : 1
stoichiometry:c228 : 1
m33*0.1
nodelay
--
0
PMID: 17275323 Conventional DC derived from IRF1-deficient mice display impaired induction of IFNbeta, inducible nitric-oxide synthase and IL-12 p35, in response to a TLR9 ligand.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c24 : 1
stoichiometry:c25 : 1
m15*m18*0.1
nodelay
--
0
PMID: 17275323, 16497588 In particular, TLR1/2 and TLR2/6 can discriminate triacyl- and diacyl-lipopeptide, respectively.
p80
p80
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c231 : 1
stoichiometry:c232 : 1
stoichiometry:c234 : 1
stoichiometry:c233 : 1
m1572*m970*m1639*0.1
nodelay
--
0
PMID: 17275323 IRF1 is recruited to MyD88 when it is induced by IFNgamma stimulation, and translocates into the nucleus in response to TLR stimulation to induce a set of genes including IFNbeta in conventional DC.
p81
p81
cso30:i:ME_GeneExpression
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c235 : 1
stoichiometry:c236 : 1
m1639*0.1
nodelay
--
0
PMID: 17275323 IFNgamma stimulation induces IRF1 expression.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c238 : 1
stoichiometry:c237 : 1
m105*0.1
nodelay
--
0
PMID: 17275323 IRF1 is recruited to MyD88 when it is induced by IFNgamma stimulation, and translocates into the nucleus in response to TLR stimulation to induce a set of genes including IFNbeta in conventional DC.
p83
p83
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c239 : 1
stoichiometry:c241 : 1
stoichiometry:c242 : 1
stoichiometry:c354 : 1
stoichiometry:c240 : 1
m1572*m979*m183*0.1
nodelay
--
0
PMID: 17275323 IRF5 binds MyD88 and TRAF6 and moves to the nucleus after phosphorylation. PMID: 17275323 As expression of the IRF4 gene is upregulated after exposure with TLR ligands, the induced IRF4 might associate with MyD88 to prevent recruitment of IRF5, thereby attenuating IRF5-dependent inflammatory responses.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c243 : 1
stoichiometry:c244 : 1
m106*0.1
nodelay
--
0
PMID: 17275323 IRF5 binds MyD88 and TRAF6 and moves to the nucleus after phosphorylation.
p85
p85
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c245 : 1
stoichiometry:c246 : 1
stoichiometry:c248 : 1
stoichiometry:c247 : 1
m6*m19005*m1629*0.1
nodelay
--
0
PMID: 17275323, 16757566 TRAM is phosphorylated at serine 16 by PKCepsilon in response to LPS.
p87
p87
cso30:i:ME_UnknownProduction
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c361 : 1
stoichiometry:c250 : 1
m122*0.1
nodelay
--
0
PMID: 17275323 Integrin signaling regulates the production of PIP2 through the activation of ARF6 GTPase and PI5K.
p88
p88
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c252 : 1
stoichiometry:c256 : 1
stoichiometry:c253 : 1
m113*m2142*0.1
nodelay
--
0
PMID: 17275323 Integrin signaling regulates the production of PIP2 through the activation of ARF6 GTPase and PI5K.
p9
p9
cso30:i:ME_Binding
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c26 : 1
stoichiometry:c27 : 1
stoichiometry:c28 : 1
m3963*m19942*0.1
nodelay
--
0
PMID: 17275323, 16497588 In addition, human TLR10 is thought to heterodimerize with TLR2 and TLR1, although a ligand for these heterodimers remains unknown.
p90
p90
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c260 : 1
stoichiometry:c261 : 1
stoichiometry:c275 : 1
stoichiometry:c262 : 1
m87*m1572*0.1
nodelay
--
0
PMID: 17275323 These findings suggest that TLR4 recruits TIRAP to the plasma membrane as a result of CD11b-mediated production of PIP2, which subsequently recruits MyD88 after which the signaling complex is assembled to initiate the MyD88-dependent signaling. PMID: 17275323 ST2L sequesters MyD88 and TIRAP to inhibit the recruitment of these adapters to TLR4.
p91
p91
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c263 : 1
stoichiometry:c265 : 1
stoichiometry:c264 : 1
m123*m2142*0.1
nodelay
--
0
p93
p93
cso30:i:ME_Binding
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c268 : 1
stoichiometry:c269 : 1
stoichiometry:c270 : 1
m1632*m6500*0.1
nodelay
--
0
PMID: 17275323 The LRR of RP105 associate with MD-1 to form a complex on the cell surface.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c271 : 1
stoichiometry:c273 : 1
stoichiometry:c272 : 1
m124*m126*0.1
nodelay
--
0
PMID: 17275323, 9686597 the RP105-MD-1 complex interacts with a TLR4-MD-2 complex to prevent LPS binding to TLR4-MD-2.
p95
p95
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c277 : 1
stoichiometry:c278 : 1
stoichiometry:c279 : 1
stoichiometry:c280 : 1
m41575*m6176*m183*0.1
nodelay
--
0
PMID: 17275323 SIGIRR interacts with IRAKs and TRAF6 to block TLR signaling.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c281 : 1
stoichiometry:c282 : 1
stoichiometry:c286 : 1
m128*m3961*0.1
nodelay
--
0
PMID: 17275323 Triad3A is an E3 ligase that binds the TIR domain of TLR4 and 9, but not that of TLR2.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c283 : 1
stoichiometry:c284 : 1
stoichiometry:c285 : 1
m19828*m128*0.1
nodelay
--
0
PMID: 17275323 Triad3A is an E3 ligase that binds the TIR domain of TLR4 and 9, but not that of TLR2.
p98
p98
cso30:i:ME_ProteasomeDegradation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c288 : 1
stoichiometry:c289 : 1
stoichiometry:c292 : 1
m129*0.1
nodelay
--
0
PMID: 17275323 Triad3 overexpression promotes degradation of TLR4 and 9 via a proteasome-dependent pathway.
p99
p99
cso30:i:ME_ProteasomeDegradation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c287 : 1
stoichiometry:c290 : 1
stoichiometry:c291 : 1
m130*0.1
nodelay
--
0
PMID: 17275323 Triad3 overexpression promotes degradation of TLR4 and 9 via a proteasome-dependent pathway.
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--