<?xml version="1.0" encoding="UTF-8" standalone="yes"?>
<csml:project majorVersion="3" minorVersion="0" projectID="local" projectVersionID="undef" xmlns:csml="http://www.csml.org/csml/version3" xmlns:xlink="http://www.w3.org/1999/xlink">
<csml:model modelID="undef" modelVersionID="undef">
<csml:entitySet>
<csml:entity id="e10" name="" type="cso30:c:EntityBiologicalCompartment">
<csml:entitySimulationProperty>
<csml:variable variableID="m10" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="true"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="169.30729458223453" y="133.68602759414952"/>
<csml:shape shapeID="default" depth="72" visible="true">
<csml:image width="821.6703035400759" height="1155.8590760699524" filePath="" fileType="internal" fileFormat="svg" resourceID="20045" outlineColor="0 0 0 0">&lt;svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" style="overflow:visible;enable-background:new 0 0 431.413 43.583" viewBox="0 0 428.047 656.027" preserveAspectRatio="xMidYMid meet" zoomAndPan="magnify" width="428.047" height="656.027" contentScriptType="text/ecmascript" contentStyleType="text/css" version="1.0"&gt;&lt;defs&gt;&lt;linearGradient xmlns:xlink="http://www.w3.org/1999/xlink" id="color2" gradientUnits="objectBoundingBox" gradientTransform="" x1="0%" y1="0%" x2="100%" y2="0%" spreadMethod="pad"&gt;&lt;stop style="stop-color:#000000;stop-opacity:1;" offset="0%"&gt;&lt;/stop&gt;&lt;/linearGradient&gt;&lt;linearGradient xmlns:xlink="http://www.w3.org/1999/xlink" id="color3" gradientUnits="objectBoundingBox" gradientTransform="" x1="0%" y1="0%" x2="100%" y2="0%" spreadMethod="pad"&gt;&lt;stop style="stop-color:#0000ff;stop-opacity:1;" offset="0%"&gt;&lt;/stop&gt;&lt;/linearGradient&gt;&lt;linearGradient xmlns:xlink="http://www.w3.org/1999/xlink" id="stroke1" gradientUnits="objectBoundingBox" gradientTransform="" x1="0%" y1="0%" x2="100%" y2="0%" spreadMethod="pad"&gt;&lt;stop style="stop-color:#808080;stop-opacity:1;" offset="0%"&gt;&lt;/stop&gt;&lt;/linearGradient&gt;&lt;linearGradient xmlns:xlink="http://www.w3.org/1999/xlink" id="stroke2" gradientUnits="objectBoundingBox" gradientTransform="" x1="0%" y1="0%" x2="100%" y2="0%" spreadMethod="pad"&gt;&lt;stop style="stop-color:#008000;stop-opacity:1;" offset="0%"&gt;&lt;/stop&gt;&lt;/linearGradient&gt;&lt;linearGradient xmlns:xlink="http://www.w3.org/1999/xlink" id="stroke3" gradientUnits="objectBoundingBox" gradientTransform="" x1="0%" y1="0%" x2="100%" y2="0%" spreadMethod="pad"&gt;&lt;stop style="stop-color:#00ff00;stop-opacity:1;" offset="0%"&gt;&lt;/stop&gt;&lt;/linearGradient&gt;&lt;linearGradient xmlns:xlink="http://www.w3.org/1999/xlink" id="color1" gradientUnits="objectBoundingBox" gradientTransform="" x1="0%" y1="0%" x2="100%" y2="0%" spreadMethod="pad"&gt;&lt;stop style="stop-color:#E6F6F9;stop-opacity:1;" offset="0%"&gt;&lt;/stop&gt;&lt;/linearGradient&gt;&lt;/defs&gt;&lt;path style="fill:url(#color1);stroke:none;" d="M11.134,0C4.995,0,0,5.273,0,11.754v632.517c0,6.48,4.995,11.756,11.134,11.756h405.778 c6.141,0,11.135-5.273,11.135-11.756V11.754C428.047,5.273,423.053,0,416.912,0H11.134z"&gt;&lt;/path&gt;&lt;/svg&gt;</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
indirect</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e9" name="" type="cso30:c:EntityBiologicalCompartment">
<csml:entitySimulationProperty>
<csml:variable variableID="m9" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="true"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="177.0" y="131.0"/>
<csml:shape shapeID="default" depth="81" visible="true">
<csml:image width="801.8791759029863" height="1154.3288303559784" filePath="system" fileType="resourceFile" fileFormat="svg" resourceID="20046" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Cytoplasm">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e7" name="" type="cso30:c:EntityBiologicalCompartment">
<csml:entitySimulationProperty>
<csml:variable variableID="m7" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="true"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="166.0" y="89.0"/>
<csml:shape shapeID="default" depth="100" visible="true">
<csml:image width="839.7237354966342" height="1189.8668429177399" filePath="system" fileType="resourceFile" fileFormat="svg" resourceID="20004" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Cell">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e8" name="" type="cso30:c:EntityBiologicalCompartment">
<csml:entitySimulationProperty>
<csml:variable variableID="m8" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="true"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="169.0" y="110.0"/>
<csml:shape shapeID="default" depth="90" visible="true">
<csml:image width="805.5569854171277" height="1169.6687428256696" filePath="system" fileType="resourceFile" fileFormat="svg" resourceID="20068" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Cell_WithoutCellWall_">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="MO000008179" name="PKR" refUnificationXrefID="ref0;ref1;ref2;ref3;ref4;" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable variableID="m1055" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="338.0" y="194.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="20.0" height="20.0" filePath="" fileType="internal" fileFormat="svg" outlineColor="0 0 0 0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" viewBox="0 0 60.0 60.0" height="60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;
&lt;radialGradient id="MO_cf8fbc" gradientUnits="objectBoundingBox" spreadMethod="pad" xlink:show="other" xlink:type="simple" r="50%" cx="50%" fx="50%" cy="50%" fy="50%" xlink:actuate="onLoad"&gt;
&lt;stop style="stop-color:white;stop-opacity:1;" offset="0%"/&gt;
&lt;stop style="stop-color:#cf8fbc;stop-opacity:1;" offset="0%"/&gt;
&lt;/radialGradient&gt;
&lt;/defs&gt;
&lt;path d="M 60 48.5409 c 4.9597 -5.4931 13.9817 -9.4903 -14.709 -11.4335 l 14.709 -25.6484 c -3.9607 -6.1835 -5.1697 -15.5791 -15.9786 9.7711 l -21.1031 -21.2302 c -7.4073 1.6713 -17.1768 -0.1382 4.8333 17.4724 l -27.7516 12.5276 c -0.6176 7.2162 -5.4462 15.4933 18.9664 1.0276 l 3.9519 28.9724 c 7.0259 2.7885 13.8109 9.7142 6.8879 -16.8376 l 30.1938 5.3786 z" style="fill:url(#MO_cf8fbc);stroke:none;"/&gt;
&lt;/svg&gt;
</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="MO000022225" name="dsRNA:PKR" refUnificationXrefID="ref5;" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable variableID="m6524" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="442.0" y="198.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="20.0" height="20.0" filePath="" fileType="internal" fileFormat="svg" outlineColor="0 0 0 0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" height="60.0" viewBox="0 0 60.0 60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;
&lt;radialGradient id="MO_691efd" gradientUnits="objectBoundingBox" spreadMethod="pad" xlink:show="other" xlink:type="simple" r="50%" cx="50%" fx="50%" fy="50%" cy="50%" xlink:actuate="onLoad"&gt;
&lt;stop offset="0%" style="stop-color:white;stop-opacity:1;"/&gt;
&lt;stop offset="100%" style="stop-color:#691efd;stop-opacity:1;"/&gt;
&lt;/radialGradient&gt;
&lt;/defs&gt;
&lt;path style="fill:url(#MO_691efd);stroke:none;" d="M 49.9997 25.0002 l -12.8898 -3.128 c -7.7419 0.4334 -2.5399 -5.5634 -5.8173 -5.7503 l -26.7073 -4.8992 c -7.4971 1.6382 1.3038 -5.4518 -4.5852 -11.2225 l 3.3172 11.2316 c 4.3044 5.5897 -4.2933 4.6867 -2.8418 7.2381 l 8.4543 22.4801 c 5.3869 4.8036 -6.1039 1.7481 -8.9298 9.0503 l 9.573 -8.1035 c 3.4375 -6.0231 6.8332 0.8768 8.6588 -1.4878 l 18.253 -17.5811 c 2.1102 -6.4418 4.8 3.7038 13.5152 2.1722 z" /&gt;
&lt;defs&gt;
&lt;radialGradient id="MO_cf8fbc" gradientUnits="objectBoundingBox" spreadMethod="pad" xlink:show="other" xlink:type="simple" r="50%" cx="50%" fx="50%" fy="50%" cy="50%" xlink:actuate="onLoad"&gt;
&lt;stop offset="0%" style="stop-color:white;stop-opacity:1;"/&gt;
&lt;stop offset="100%" style="stop-color:#cf8fbc;stop-opacity:1;"/&gt;
&lt;/radialGradient&gt;
&lt;/defs&gt;
&lt;path style="fill:url(#MO_cf8fbc);stroke:none;" d="M 60 50.4508 c 4.1331 -4.5776 11.6514 -7.9086 -12.2575 -9.5279 l 12.2575 -21.3737 c -3.3006 -5.1529 -4.3081 -12.9826 -13.3155 8.1426 l -17.5859 -17.6918 c -6.1728 1.3928 -14.314 -0.1152 4.0278 14.5603 l -23.1263 10.4397 c -0.5147 6.0135 -4.5385 12.9111 15.8053 0.8563 l 3.2933 24.1437 c 5.8549 2.3238 11.5091 8.0952 5.7399 -14.0313 l 25.1615 4.4822 z" /&gt;
&lt;/svg&gt;</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="MO000022224" name="dsRNA" refUnificationXrefID="ref6;" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable variableID="m119368" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="342.0" y="50.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="20.0" height="20.0" filePath="" fileType="internal" fileFormat="svg" outlineColor="0 0 0 0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" height="60.0" viewBox="0 0 60.0 60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;
&lt;radialGradient id="MO_691efd" gradientUnits="objectBoundingBox" spreadMethod="pad" xlink:show="other" xlink:type="simple" r="50%" cx="50%" fx="50%" fy="50%" cy="50%" xlink:actuate="onLoad"&gt;
&lt;stop offset="0%" style="stop-color:white;stop-opacity:1;"/&gt;
&lt;stop offset="100%" style="stop-color:#691efd;stop-opacity:1;"/&gt;
&lt;/radialGradient&gt;
&lt;/defs&gt;
&lt;path style="fill:url(#MO_691efd);stroke:none;" d="M 59.9996 30.0002 l -15.4678 -3.7536 c -9.2903 0.5201 -3.0479 -6.6761 -6.9808 -6.9004 l -32.0488 -5.8791 c -8.9965 1.9659 1.5646 -6.5422 -5.5022 -13.467 l 3.9806 13.4779 c 5.1653 6.7076 -5.152 5.624 -3.4102 8.6857 l 10.1452 26.9761 c 6.4643 5.7643 -7.3247 2.0977 -10.7157 10.8604 l 11.4876 -9.7242 c 4.125 -7.2277 8.1999 1.0521 10.3905 -1.7853 l 21.9036 -21.0973 c 2.5322 -7.7302 5.76 4.4445 16.2183 2.6067 z" /&gt;
&lt;/svg&gt;</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e5" name="Poly(I:C)" type="cso30:c:SmallMolecule">
<csml:entitySimulationProperty>
<csml:variable variableID="m5" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="415.0" y="34.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="49.478553406223725" height="28.037846930193446" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="65" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e6" name="PKR:Poly(I:C)" type="cso30:c:Complex">
<csml:entitySimulationProperty>
<csml:variable variableID="m6" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="526.5" y="188.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="19.253791034827533" height="23.576070654890856" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="12" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e11" name="eIF2alpha" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable variableID="m11" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="397.0" y="259.5"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="21.6" height="16.2" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="34" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e12" name="eIF2alpha{p}" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable variableID="m12" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="445.0" y="387.5"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="21.6" height="16.2" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="34" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="MO000019398" name="TLR3" refUnificationXrefID="ref7;ref8;ref9;ref10;ref11;ref12;" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable variableID="m3965" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="699.0" y="211.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="18.0" height="18.0" filePath="" fileType="internal" fileFormat="svg" outlineColor="0 0 0 0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" height="60.0" viewBox="0 0 60.0 60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;
&lt;radialGradient id="MO_933f3f" gradientUnits="objectBoundingBox" spreadMethod="pad" xlink:show="other" xlink:type="simple" r="50%" cx="50%" fx="50%" fy="50%" cy="50%" xlink:actuate="onLoad"&gt;
&lt;stop offset="0%" style="stop-color:white;stop-opacity:1;"/&gt;
&lt;stop offset="100%" style="stop-color:#933f3f;stop-opacity:1;"/&gt;
&lt;/radialGradient&gt;
&lt;/defs&gt;
&lt;path style="fill:url(#MO_933f3f);stroke:none;" d="M 60 48.54 l -0.3772 -11.808 c 13.6534 -12.4868 26.6272 14.8035 0.3772 -25.2737 l -11.9246 -3.3074 c -8.2669 -16.2079 23.0311 -19.5108 -25.1571 -8.1508 l -6.993 9.7635 c -18.7631 2.4691 -12.3928 -26.8612 -15.9253 20.2365 l 7.6025 9.3425 c -3.3288 17.7341 -30.6905 2.909 15.3149 20.6575 l 11.6914 -3.9898 c 16.7054 8.4916 -6.575 28.6596 25.3903 -7.4684 z" /&gt;
&lt;/svg&gt;</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e16" name="TLR3:Poly(I:C)" type="cso30:c:Complex">
<csml:entitySimulationProperty>
<csml:variable variableID="m16" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="660.5" y="258.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="22.238982679237008" height="43.04319228239421" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="6" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e17" name="Viral Glycoproteins" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable variableID="m17" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="102.0" y="103.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="11.540692235734328" height="26.63236669784845" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="36" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="MO000019397" name="TLR2" refUnificationXrefID="ref13;ref14;ref15;ref16;ref17;ref18;ref19;" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable variableID="m3964" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="186.0" y="118.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="20.0" height="20.0" filePath="" fileType="internal" fileFormat="svg" outlineColor="0 0 0 0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" height="60.0" viewBox="0 0 60.0 60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;
&lt;radialGradient id="MO_930942" gradientUnits="objectBoundingBox" spreadMethod="pad" xlink:show="other" xlink:type="simple" r="50%" cx="50%" fx="50%" fy="50%" cy="50%" xlink:actuate="onLoad"&gt;
&lt;stop offset="0%" style="stop-color:white;stop-opacity:1;"/&gt;
&lt;stop offset="100%" style="stop-color:#930942;stop-opacity:1;"/&gt;
&lt;/radialGradient&gt;
&lt;/defs&gt;
&lt;path style="fill:url(#MO_930942);stroke:none;" d="M 60 48.54 l -0.3772 -11.808 c 13.6534 -12.4868 26.6272 14.8035 0.3772 -25.2737 l -11.9246 -3.3074 c -8.2669 -16.2079 23.0311 -19.5108 -25.1571 -8.1508 l -6.993 9.7635 c -18.7631 2.4691 -12.3928 -26.8612 -15.9253 20.2365 l 7.6025 9.3425 c -3.3288 17.7341 -30.6905 2.909 15.3149 20.6575 l 11.6914 -3.9898 c 16.7054 8.4916 -6.575 28.6596 25.3903 -7.4684 z" /&gt;
&lt;/svg&gt;</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e18" name="Viral Glycoproteins:TLR2" type="cso30:c:Complex">
<csml:entitySimulationProperty>
<csml:variable variableID="m18" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="178.5" y="214.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="18.249287436965577" height="35.32120149090112" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="6" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e19" name="CpG dinucleotides" type="cso30:c:Dna">
<csml:entitySimulationProperty>
<csml:variable variableID="m19" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="1062.0" y="253.5"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="60.0" height="13.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="3" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="MO000042012" name="TLR9" refUnificationXrefID="ref20;" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable variableID="m19828" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="834.0" y="270.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="20.0" height="20.0" filePath="" fileType="internal" fileFormat="svg" outlineColor="0 0 0 0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" height="60.0" viewBox="0 0 60.0 60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;
&lt;radialGradient id="MO_933448" gradientUnits="objectBoundingBox" spreadMethod="pad" xlink:show="other" xlink:type="simple" r="50%" cx="50%" fx="50%" fy="50%" cy="50%" xlink:actuate="onLoad"&gt;
&lt;stop offset="0%" style="stop-color:white;stop-opacity:1;"/&gt;
&lt;stop offset="100%" style="stop-color:#933448;stop-opacity:1;"/&gt;
&lt;/radialGradient&gt;
&lt;/defs&gt;
&lt;path style="fill:url(#MO_933448);stroke:none;" d="M 60 48.54 l -0.3772 -11.808 c 13.6534 -12.4868 26.6272 14.8035 0.3772 -25.2737 l -11.9246 -3.3074 c -8.2669 -16.2079 23.0311 -19.5108 -25.1571 -8.1508 l -6.993 9.7635 c -18.7631 2.4691 -12.3928 -26.8612 -15.9253 20.2365 l 7.6025 9.3425 c -3.3288 17.7341 -30.6905 2.909 15.3149 20.6575 l 11.6914 -3.9898 c 16.7054 8.4916 -6.575 28.6596 25.3903 -7.4684 z" /&gt;
&lt;/svg&gt;</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e20" name="TLR9:CpG dinucleotides" type="cso30:c:Complex">
<csml:entitySimulationProperty>
<csml:variable variableID="m20" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="858.5" y="317.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="19.234816926112696" height="37.22867792150845" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="6" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_EndosomeLumen">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e21" name="ssRNA" type="cso30:c:Dna">
<csml:entitySimulationProperty>
<csml:variable variableID="m21" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="1070.0" y="394.5"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="60.0" height="19.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="45" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Extracellular">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="MO000042126" name="TLR7" refUnificationXrefID="ref21;" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable variableID="m19940" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="870.0" y="382.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="20.0" height="20.0" filePath="" fileType="internal" fileFormat="svg" outlineColor="0 0 0 0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" height="60.0" viewBox="0 0 60.0 60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;
&lt;radialGradient id="MO_bc3b31" gradientUnits="objectBoundingBox" spreadMethod="pad" xlink:show="other" xlink:type="simple" r="50%" cx="50%" fx="50%" fy="50%" cy="50%" xlink:actuate="onLoad"&gt;
&lt;stop offset="0%" style="stop-color:white;stop-opacity:1;"/&gt;
&lt;stop offset="100%" style="stop-color:#bc3b31;stop-opacity:1;"/&gt;
&lt;/radialGradient&gt;
&lt;/defs&gt;
&lt;path style="fill:url(#MO_bc3b31);stroke:none;" d="M 60 48.54 l -0.3772 -11.808 c 13.6534 -12.4868 26.6272 14.8035 0.3772 -25.2737 l -11.9246 -3.3074 c -8.2669 -16.2079 23.0311 -19.5108 -25.1571 -8.1508 l -6.993 9.7635 c -18.7631 2.4691 -12.3928 -26.8612 -15.9253 20.2365 l 7.6025 9.3425 c -3.3288 17.7341 -30.6905 2.909 15.3149 20.6575 l 11.6914 -3.9898 c 16.7054 8.4916 -6.575 28.6596 25.3903 -7.4684 z" /&gt;
&lt;/svg&gt;</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e22" name="TLR7:ssRNA" type="cso30:c:Complex">
<csml:entitySimulationProperty>
<csml:variable variableID="m22" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="858.5" y="422.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="18.636702477526857" height="36.07103705327779" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="6" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_EndosomeLumen">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="MO000042007" name="TLR8" refUnificationXrefID="ref22;" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable variableID="m19823" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="862.0" y="470.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="20.0" height="20.0" filePath="" fileType="internal" fileFormat="svg" outlineColor="0 0 0 0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" height="60.0" viewBox="0 0 60.0 60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;
&lt;radialGradient id="MO_ac3e3e" gradientUnits="objectBoundingBox" spreadMethod="pad" xlink:show="other" xlink:type="simple" r="50%" cx="50%" fx="50%" fy="50%" cy="50%" xlink:actuate="onLoad"&gt;
&lt;stop offset="0%" style="stop-color:white;stop-opacity:1;"/&gt;
&lt;stop offset="100%" style="stop-color:#ac3e3e;stop-opacity:1;"/&gt;
&lt;/radialGradient&gt;
&lt;/defs&gt;
&lt;path style="fill:url(#MO_ac3e3e);stroke:none;" d="M 60 48.54 l -0.3772 -11.808 c 13.6534 -12.4868 26.6272 14.8035 0.3772 -25.2737 l -11.9246 -3.3074 c -8.2669 -16.2079 23.0311 -19.5108 -25.1571 -8.1508 l -6.993 9.7635 c -18.7631 2.4691 -12.3928 -26.8612 -15.9253 20.2365 l 7.6025 9.3425 c -3.3288 17.7341 -30.6905 2.909 15.3149 20.6575 l 11.6914 -3.9898 c 16.7054 8.4916 -6.575 28.6596 25.3903 -7.4684 z" /&gt;
&lt;/svg&gt;</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e23" name="TLR8:ssRNA" type="cso30:c:Complex">
<csml:entitySimulationProperty>
<csml:variable variableID="m23" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="839.5" y="519.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="17.59000219250164" height="34.045165533874155" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="6" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="MO000041125" name="TRIF" refUnificationXrefID="ref23;" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable variableID="m18998" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="539.0" y="347.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="18.0" height="18.0" filePath="" fileType="internal" fileFormat="svg" outlineColor="0 0 0 0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" height="60.0" viewBox="0 0 60.0 60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;
&lt;radialGradient id="MO_59ab14" gradientUnits="objectBoundingBox" spreadMethod="pad" xlink:show="other" xlink:type="simple" r="50%" cx="50%" fx="50%" fy="50%" cy="50%" xlink:actuate="onLoad"&gt;
&lt;stop offset="0%" style="stop-color:white;stop-opacity:1;"/&gt;
&lt;stop offset="100%" style="stop-color:#59ab14;stop-opacity:1;"/&gt;
&lt;/radialGradient&gt;
&lt;/defs&gt;
&lt;path style="fill:url(#MO_59ab14);stroke:none;" d="M 60 48.5415 c 0.8103 -7.397 2.3214 -19.8066 -3.5398 -20.1631 c 9.5776 -10.3066 -2.5463 -7.5712 3.5398 -16.9193 c -7.1467 -3.0187 -19.0893 -8.2203 -21.2568 -3.0292 c -7.3468 -11.8479 -8.3579 -0.0366 -15.8253 -8.4299 c -5.2269 5.5315 -14.1193 14.7258 -9.5978 18.2907 c -14.118 2.984 -2.6193 7.5483 -13.3201 11.7096 c 3.9166 6.4373 10.3631 17.3217 15.3246 14.3334 c -1.3787 13.6923 6.7392 4.7019 7.5932 15.6663 c 7.6473 -1.5531 20.5241 -4.0206 19.0691 -9.4324 c 13.2666 5.4782 6.7842 -4.643 18.013 -2.0267 z" /&gt;
&lt;/svg&gt;</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e24" name="mRNA" type="cso30:c:mRNA">
<csml:entitySimulationProperty>
<csml:variable variableID="m24" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="364.0" y="769.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="39.653979238754324" height="21.148788927335644" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="9" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Nucleoplasm">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e25" name="protein" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable variableID="m25" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="319.0" y="720.5"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="25.622861742805394" height="15.800764741396659" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="11" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="MO000016573" name="MyD88" refUnificationXrefID="ref24;ref25;ref26;ref27;" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable variableID="m1572" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="265.0" y="165.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="22.0" height="22.0" filePath="" fileType="internal" fileFormat="svg" outlineColor="0 0 0 0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" viewBox="0 0 60.0 60.0" height="60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;
&lt;radialGradient id="MO_d14d35" gradientUnits="objectBoundingBox" spreadMethod="pad" xlink:show="other" xlink:type="simple" r="50%" cx="50%" fx="50%" cy="50%" fy="50%" xlink:actuate="onLoad"&gt;
&lt;stop style="stop-color:white;stop-opacity:1;" offset="0%"/&gt;
&lt;stop style="stop-color:#d14d35;stop-opacity:1;" offset="0%"/&gt;
&lt;/radialGradient&gt;
&lt;/defs&gt;
&lt;path d="M 45.6589 40.7351 c -12.8034 -17.2246 -3.4958 -15.396 14.3411 -6.9145 c -5.6247 -21.6076 15.286 -16.8559 -23.1584 -3.4266 l 8.8172 -14.5467 c -20.2529 6.9178 -15.6471 -1.4149 -2.1102 -15.8473 c -22.1809 -1.2997 -11.2242 -19.8223 -10.3989 21.0812 l -11.038 -12.9242 c 0.2862 21.4997 -6.1744 14.5214 -15.6455 -2.8798 c -8.0838 20.8041 -22.2224 4.6053 16.7319 16.4554 l -15.639 6.5589 c 20.4302 6.3701 11.8309 10.3902 -7.5593 14.0677 c 17.1848 14.1568 -2.5103 22.6686 20.7392 -10.9109 l 1.3726 16.9777 c 12.3399 -17.563 13.4865 -8.0998 10.9738 11.5738 c 18.7046 -12.0544 20.6709 9.4044 -3.9138 -23.1991 l 16.4871 3.9342 z" style="fill:url(#MO_d14d35);stroke:none;"/&gt;
&lt;/svg&gt;
</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="MO000022528" name="TIRAP" refUnificationXrefID="ref28;ref29;" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable variableID="m6810" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="235.0" y="295.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="18.0" height="18.0" filePath="" fileType="internal" fileFormat="svg" outlineColor="0 0 0 0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" height="60.0" viewBox="0 0 60.0 60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;
&lt;radialGradient id="MO_3ae13a" gradientUnits="objectBoundingBox" spreadMethod="pad" xlink:show="other" xlink:type="simple" r="50%" cx="50%" fx="50%" fy="50%" cy="50%" xlink:actuate="onLoad"&gt;
&lt;stop offset="0%" style="stop-color:white;stop-opacity:1;"/&gt;
&lt;stop offset="100%" style="stop-color:#3ae13a;stop-opacity:1;"/&gt;
&lt;/radialGradient&gt;
&lt;/defs&gt;
&lt;path style="fill:url(#MO_3ae13a);stroke:none;" d="M 60 48.5415 c 0.8103 -7.397 2.3214 -19.8066 -3.5398 -20.1631 c 9.5776 -10.3066 -2.5463 -7.5712 3.5398 -16.9193 c -7.1467 -3.0187 -19.0893 -8.2203 -21.2568 -3.0292 c -7.3468 -11.8479 -8.3579 -0.0366 -15.8253 -8.4299 c -5.2269 5.5315 -14.1193 14.7258 -9.5978 18.2907 c -14.118 2.984 -2.6193 7.5483 -13.3201 11.7096 c 3.9166 6.4373 10.3631 17.3217 15.3246 14.3334 c -1.3787 13.6923 6.7392 4.7019 7.5932 15.6663 c 7.6473 -1.5531 20.5241 -4.0206 19.0691 -9.4324 c 13.2666 5.4782 6.7842 -4.643 18.013 -2.0267 z" /&gt;
&lt;/svg&gt;</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e26" name="Viral Glycoproteins:TLR2:Mal:MyD88" type="cso30:c:Complex">
<csml:entitySimulationProperty>
<csml:variable variableID="m26" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="172.0" y="276.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="24.08823529411765" height="40.14705882352941" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="31" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="MO000000058" name="NF-kappaB{active}" refUnificationXrefID="ref30;" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable variableID="m27" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="403.0" y="567.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="26.0" height="26.0" filePath="" fileType="internal" fileFormat="svg" outlineColor="0 0 0 0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" viewBox="0 0 60.0 60.0" height="60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;
&lt;radialGradient id="MO_c0a85b" gradientUnits="objectBoundingBox" spreadMethod="pad" xlink:show="other" xlink:type="simple" r="50%" cx="50%" fx="50%" cy="50%" fy="50%" xlink:actuate="onLoad"&gt;
&lt;stop style="stop-color:white;stop-opacity:1;" offset="0%"/&gt;
&lt;stop style="stop-color:#c0a85b;stop-opacity:1;" offset="0%"/&gt;
&lt;/radialGradient&gt;
&lt;/defs&gt;
&lt;path d="M 59.9987 30 c -33.2435 0.7613 5.9036 22.2992 -25.8364 -16.4278 l -1.8953 25.5774 c -14.6426 13.9063 -31.9178 -9.3883 -29.5118 -39.1497 c 17.3491 25.7524 18.323 -15.7914 -2.7553 28.5239 l 25.3495 -11.2984 c 20.5888 4.5578 7.0015 29.7852 -22.5942 42.7745 c 15.8957 -26.5149 -24.2266 -6.5088 28.5917 -12.0961 l -23.4542 -14.2779 c -5.9449 -18.4641 24.9151 -20.397 52.1072 -3.6249 z" style="fill:url(#MO_c0a85b);stroke:none;"/&gt;
&lt;/svg&gt;
</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e27" name="NF-kappaB" refUnificationXrefID="ref31;" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable variableID="m28" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="359.0" y="499.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="26.0" height="26.0" filePath="" fileType="internal" fileFormat="svg" outlineColor="0 0 0 0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" viewBox="0 0 60.0 60.0" height="60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;
&lt;radialGradient id="MO_c0a85b" gradientUnits="objectBoundingBox" spreadMethod="pad" xlink:show="other" xlink:type="simple" r="50%" cx="50%" fx="50%" cy="50%" fy="50%" xlink:actuate="onLoad"&gt;
&lt;stop style="stop-color:white;stop-opacity:1;" offset="0%"/&gt;
&lt;stop style="stop-color:#c0a85b;stop-opacity:1;" offset="0%"/&gt;
&lt;/radialGradient&gt;
&lt;/defs&gt;
&lt;path d="M 59.9987 30 c -33.2435 0.7613 5.9036 22.2992 -25.8364 -16.4278 l -1.8953 25.5774 c -14.6426 13.9063 -31.9178 -9.3883 -29.5118 -39.1497 c 17.3491 25.7524 18.323 -15.7914 -2.7553 28.5239 l 25.3495 -11.2984 c 20.5888 4.5578 7.0015 29.7852 -22.5942 42.7745 c 15.8957 -26.5149 -24.2266 -6.5088 28.5917 -12.0961 l -23.4542 -14.2779 c -5.9449 -18.4641 24.9151 -20.397 52.1072 -3.6249 z" style="fill:url(#MO_c0a85b);stroke:none;"/&gt;
&lt;/svg&gt;
</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e28" name="TLR3:Poly(I:C):TRIF" type="cso30:c:Complex">
<csml:entitySimulationProperty>
<csml:variable variableID="m29" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="664.5" y="324.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="23.547806937052673" height="32.8574050284456" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="30" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_EndosomeLumen">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="MO000007694" name="IRF-3" refUnificationXrefID="ref32;ref33;ref34;" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable variableID="m977" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="456.0" y="424.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="23.0" height="23.0" filePath="" fileType="internal" fileFormat="svg" outlineColor="0 0 0 0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" viewBox="0 0 60.0 60.0" height="60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;
&lt;radialGradient id="MO_6ad24b" gradientUnits="objectBoundingBox" spreadMethod="pad" xlink:show="other" xlink:type="simple" r="50%" cx="50%" fx="50%" cy="50%" fy="50%" xlink:actuate="onLoad"&gt;
&lt;stop style="stop-color:white;stop-opacity:1;" offset="0%"/&gt;
&lt;stop style="stop-color:#6ad24b;stop-opacity:1;" offset="1%"/&gt;
&lt;/radialGradient&gt;
&lt;/defs&gt;
&lt;path d="M 60 48.5413 c -5.4791 -8.878 6.0417 -4.3573 -9.8171 -2.9348 l -4.5651 -27.6151 c -1.9754 -5.4859 12.2339 -9.9822 14.3816 -6.5322 c -10.571 2.2124 -2.4899 -6.8115 -5.9681 7.9727 l -29.0256 -4.4044 c -6.096 0.0919 -6.2013 -14.1503 -2.0879 -15.0274 c -1.0542 10.2454 -7.5808 0.1474 6.1282 7.8622 l -13.374 24.8929 c -1.7923 5.5423 -16.0665 1.2366 -15.6721 -2.7553 c 9.9194 4.1194 -2.1948 6.9024 9.7557 -3.1134 l 20.7599 19.7894 c 4.9886 3.3337 -3.7283 14.915 -7.5982 13.3243 c 7.1844 -7.6993 6.2238 4.1184 -0.0987 -9.7867 l 26.2042 -12.6627 c 4.875 -3.4821 13.7627 7.9809 10.9766 10.9902 z" style="fill:url(#MO_6ad24b);stroke:none;"/&gt;
&lt;/svg&gt;
</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e29" name="IRF-3{active}" refUnificationXrefID="ref35;ref36;ref37;" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable variableID="m30" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="516.0" y="476.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="23.0" height="23.0" filePath="" fileType="internal" fileFormat="svg" outlineColor="0 0 0 0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" viewBox="0 0 60.0 60.0" height="60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;
&lt;radialGradient id="MO_6ad24b" gradientUnits="objectBoundingBox" spreadMethod="pad" xlink:show="other" xlink:type="simple" r="50%" cx="50%" fx="50%" cy="50%" fy="50%" xlink:actuate="onLoad"&gt;
&lt;stop style="stop-color:white;stop-opacity:1;" offset="0%"/&gt;
&lt;stop style="stop-color:#6ad24b;stop-opacity:1;" offset="1%"/&gt;
&lt;/radialGradient&gt;
&lt;/defs&gt;
&lt;path d="M 60 48.5413 c -5.4791 -8.878 6.0417 -4.3573 -9.8171 -2.9348 l -4.5651 -27.6151 c -1.9754 -5.4859 12.2339 -9.9822 14.3816 -6.5322 c -10.571 2.2124 -2.4899 -6.8115 -5.9681 7.9727 l -29.0256 -4.4044 c -6.096 0.0919 -6.2013 -14.1503 -2.0879 -15.0274 c -1.0542 10.2454 -7.5808 0.1474 6.1282 7.8622 l -13.374 24.8929 c -1.7923 5.5423 -16.0665 1.2366 -15.6721 -2.7553 c 9.9194 4.1194 -2.1948 6.9024 9.7557 -3.1134 l 20.7599 19.7894 c 4.9886 3.3337 -3.7283 14.915 -7.5982 13.3243 c 7.1844 -7.6993 6.2238 4.1184 -0.0987 -9.7867 l 26.2042 -12.6627 c 4.875 -3.4821 13.7627 7.9809 10.9766 10.9902 z" style="fill:url(#MO_6ad24b);stroke:none;"/&gt;
&lt;/svg&gt;
</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="MO000007700" name="IRF-5" refUnificationXrefID="ref38;ref39;ref40;" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable variableID="m979" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="586.0" y="546.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="20.0" height="20.0" filePath="" fileType="internal" fileFormat="svg" outlineColor="0 0 0 0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" viewBox="0 0 60.0 60.0" height="60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;
&lt;radialGradient id="MO_6aed53" gradientUnits="objectBoundingBox" spreadMethod="pad" xlink:show="other" xlink:type="simple" r="50%" cx="50%" fx="50%" cy="50%" fy="50%" xlink:actuate="onLoad"&gt;
&lt;stop style="stop-color:white;stop-opacity:1;" offset="0%"/&gt;
&lt;stop style="stop-color:#6aed53;stop-opacity:1;" offset="0%"/&gt;
&lt;/radialGradient&gt;
&lt;/defs&gt;
&lt;path d="M 60 48.5413 c -5.4791 -8.878 6.0417 -4.3573 -9.8171 -2.9348 l -4.5651 -27.6151 c -1.9754 -5.4859 12.2339 -9.9822 14.3816 -6.5322 c -10.571 2.2124 -2.4899 -6.8115 -5.9681 7.9727 l -29.0256 -4.4044 c -6.096 0.0919 -6.2013 -14.1503 -2.0879 -15.0274 c -1.0542 10.2454 -7.5808 0.1474 6.1282 7.8622 l -13.374 24.8929 c -1.7923 5.5423 -16.0665 1.2366 -15.6721 -2.7553 c 9.9194 4.1194 -2.1948 6.9024 9.7557 -3.1134 l 20.7599 19.7894 c 4.9886 3.3337 -3.7283 14.915 -7.5982 13.3243 c 7.1844 -7.6993 6.2238 4.1184 -0.0987 -9.7867 l 26.2042 -12.6627 c 4.875 -3.4821 13.7627 7.9809 10.9766 10.9902 z" style="fill:url(#MO_6aed53);stroke:none;"/&gt;
&lt;/svg&gt;
</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e30" name="IRF-5{active}" refUnificationXrefID="ref41;ref42;ref43;" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable variableID="m31" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="706.0" y="670.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="20.0" height="20.0" filePath="" fileType="internal" fileFormat="svg" outlineColor="0 0 0 0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" viewBox="0 0 60.0 60.0" height="60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;
&lt;radialGradient id="MO_6aed53" gradientUnits="objectBoundingBox" spreadMethod="pad" xlink:show="other" xlink:type="simple" r="50%" cx="50%" fx="50%" cy="50%" fy="50%" xlink:actuate="onLoad"&gt;
&lt;stop style="stop-color:white;stop-opacity:1;" offset="0%"/&gt;
&lt;stop style="stop-color:#6aed53;stop-opacity:1;" offset="0%"/&gt;
&lt;/radialGradient&gt;
&lt;/defs&gt;
&lt;path d="M 60 48.5413 c -5.4791 -8.878 6.0417 -4.3573 -9.8171 -2.9348 l -4.5651 -27.6151 c -1.9754 -5.4859 12.2339 -9.9822 14.3816 -6.5322 c -10.571 2.2124 -2.4899 -6.8115 -5.9681 7.9727 l -29.0256 -4.4044 c -6.096 0.0919 -6.2013 -14.1503 -2.0879 -15.0274 c -1.0542 10.2454 -7.5808 0.1474 6.1282 7.8622 l -13.374 24.8929 c -1.7923 5.5423 -16.0665 1.2366 -15.6721 -2.7553 c 9.9194 4.1194 -2.1948 6.9024 9.7557 -3.1134 l 20.7599 19.7894 c 4.9886 3.3337 -3.7283 14.915 -7.5982 13.3243 c 7.1844 -7.6993 6.2238 4.1184 -0.0987 -9.7867 l 26.2042 -12.6627 c 4.875 -3.4821 13.7627 7.9809 10.9766 10.9902 z" style="fill:url(#MO_6aed53);stroke:none;"/&gt;
&lt;/svg&gt;
</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="MO000007702" name="IRF-7" refUnificationXrefID="ref44;" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable variableID="m980" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="505.0" y="645.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="22.0" height="22.0" filePath="" fileType="internal" fileFormat="svg" outlineColor="0 0 0 0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" viewBox="0 0 60.0 60.0" height="60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;
&lt;radialGradient id="MO_6aef48" gradientUnits="objectBoundingBox" spreadMethod="pad" xlink:show="other" xlink:type="simple" r="50%" cx="50%" fx="50%" cy="50%" fy="50%" xlink:actuate="onLoad"&gt;
&lt;stop style="stop-color:white;stop-opacity:1;" offset="0%"/&gt;
&lt;stop style="stop-color:#6aef48;stop-opacity:1;" offset="0%"/&gt;
&lt;/radialGradient&gt;
&lt;/defs&gt;
&lt;path d="M 60 48.5413 c -5.4791 -8.878 6.0417 -4.3573 -9.8171 -2.9348 l -4.5651 -27.6151 c -1.9754 -5.4859 12.2339 -9.9822 14.3816 -6.5322 c -10.571 2.2124 -2.4899 -6.8115 -5.9681 7.9727 l -29.0256 -4.4044 c -6.096 0.0919 -6.2013 -14.1503 -2.0879 -15.0274 c -1.0542 10.2454 -7.5808 0.1474 6.1282 7.8622 l -13.374 24.8929 c -1.7923 5.5423 -16.0665 1.2366 -15.6721 -2.7553 c 9.9194 4.1194 -2.1948 6.9024 9.7557 -3.1134 l 20.7599 19.7894 c 4.9886 3.3337 -3.7283 14.915 -7.5982 13.3243 c 7.1844 -7.6993 6.2238 4.1184 -0.0987 -9.7867 l 26.2042 -12.6627 c 4.875 -3.4821 13.7627 7.9809 10.9766 10.9902 z" style="fill:url(#MO_6aef48);stroke:none;"/&gt;
&lt;/svg&gt;
</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e31" name="IRF-7{active}" refUnificationXrefID="ref45;" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable variableID="m32" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="581.0" y="653.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="22.0" height="22.0" filePath="" fileType="internal" fileFormat="svg" outlineColor="0 0 0 0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" viewBox="0 0 60.0 60.0" height="60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;
&lt;radialGradient id="MO_6aef48" gradientUnits="objectBoundingBox" spreadMethod="pad" xlink:show="other" xlink:type="simple" r="50%" cx="50%" fx="50%" cy="50%" fy="50%" xlink:actuate="onLoad"&gt;
&lt;stop style="stop-color:white;stop-opacity:1;" offset="0%"/&gt;
&lt;stop style="stop-color:#6aef48;stop-opacity:1;" offset="0%"/&gt;
&lt;/radialGradient&gt;
&lt;/defs&gt;
&lt;path d="M 60 48.5413 c -5.4791 -8.878 6.0417 -4.3573 -9.8171 -2.9348 l -4.5651 -27.6151 c -1.9754 -5.4859 12.2339 -9.9822 14.3816 -6.5322 c -10.571 2.2124 -2.4899 -6.8115 -5.9681 7.9727 l -29.0256 -4.4044 c -6.096 0.0919 -6.2013 -14.1503 -2.0879 -15.0274 c -1.0542 10.2454 -7.5808 0.1474 6.1282 7.8622 l -13.374 24.8929 c -1.7923 5.5423 -16.0665 1.2366 -15.6721 -2.7553 c 9.9194 4.1194 -2.1948 6.9024 9.7557 -3.1134 l 20.7599 19.7894 c 4.9886 3.3337 -3.7283 14.915 -7.5982 13.3243 c 7.1844 -7.6993 6.2238 4.1184 -0.0987 -9.7867 l 26.2042 -12.6627 c 4.875 -3.4821 13.7627 7.9809 10.9766 10.9902 z" style="fill:url(#MO_6aef48);stroke:none;"/&gt;
&lt;/svg&gt;
</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="G010262" name="IL-6" refUnificationXrefID="ref46;ref47;" type="cso30:c:mRNA">
<csml:entitySimulationProperty>
<csml:variable variableID="m93248" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="439.0" y="919.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="26.0" height="26.0" filePath="" fileType="internal" fileFormat="svg" outlineColor="0 0 0 0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" height="60.0" viewBox="0 0 60.0 60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;&lt;linearGradient xmlns:xlink="http://www.w3.org/1999/xlink" gradientTransform="" gradientUnits="objectBoundingBox" id="id_#1429a2" spreadMethod="pad" x1="0%" x2="100%" y1="0%" y2="0%"&gt;&lt;stop offset="0%" style="stop-color:#1429a2;stop-opacity:1;"/&gt;&lt;stop offset="100%" style="stop-color:#1429a2;stop-opacity:1;"/&gt;&lt;/linearGradient&gt;&lt;linearGradient xmlns:xlink="http://www.w3.org/1999/xlink" gradientTransform="" gradientUnits="objectBoundingBox" id="id_#28163F" spreadMethod="pad" x1="0%" x2="100%" y1="0%" y2="0%"&gt;&lt;stop offset="0%" style="stop-color:#28163F;stop-opacity:1;"/&gt;&lt;stop offset="100%" style="stop-color:#28163F;stop-opacity:1;"/&gt;&lt;/linearGradient&gt;&lt;/defs&gt;&lt;polygon style="fill:url(#id_#28163F);stroke:none;" points="0,60 5.4121,55.4096 5.7389,55.06 6.0446,54.4747 6.3308,53.669 6.5988,52.6597 6.85,51.4625 7.086,50.0951 7.3084,48.5725 7.5185,46.9122 7.7176,45.1294 7.9075,43.2418 8.0893,41.2648 8.2647,39.2155 8.4352,37.1098 8.6021,34.9635 8.7669,32.7941 8.9312,30.6181 9.0962,28.4512 9.2635,26.3088 9.4348,24.2093 9.6113,22.1683 9.7943,20.2017 9.9856,18.3261 10.1866,16.5582 10.3987,14.9142 10.6231,13.4103 10.8617,12.0629 11.1155,10.8889 11.3866,9.9046 11.6759,9.1255 11.9852,8.5686 12.3157,8.2502 12.6689,8.1875 13.026,8.3869 13.3701,8.8365 13.702,9.519 10.3627,2.6373 9.9474,1.7838 9.5171,1.2214 9.0714,0.9722 8.6295,1.0511 8.2163,1.4488 7.8298,2.1448 7.4682,3.1188 7.1295,4.3492 6.812,5.8167 6.5139,7.5009 6.2331,9.3809 5.9681,11.4358 5.717,13.646 5.4777,15.9899 5.2488,18.4483 5.0285,20.9998 4.8145,23.6243 4.6051,26.3015 4.3989,29.0108 4.1935,31.7312 3.9875,34.443 3.7788,37.1246 3.5658,39.7578 3.3465,42.319 3.1191,44.7906 2.8818,47.1504 2.633,49.3783 2.3703,51.4539 2.0924,53.3568 1.7973,55.0662 1.4832,56.5624 1.1482,57.8244 0.7907,58.8315 0.4085,59.5636" /&gt;&lt;polygon style="fill:url(#id_#1429a2);stroke:none;" points="10.3627,2.6373 13.702,9.519 14.0227,10.4186 14.3318,11.5175 14.6304,12.7984 14.9186,14.2465 15.197,15.8431 15.4659,17.5716 15.726,19.4163 15.9776,21.3597 16.2211,23.3859 16.4571,25.4767 16.6861,27.6164 16.9084,29.7868 17.1245,31.9728 17.335,34.1571 17.5402,36.3224 17.7404,38.4523 17.9361,40.5304 18.1283,42.5388 18.3167,44.4618 18.5024,46.2823 18.6855,47.9831 18.8666,49.5479 19.0458,50.9596 19.2242,52.2015 19.4018,53.2575 19.579,54.1096 19.7564,54.7419 19.9346,55.1368 20.114,55.2787 20.3337,55.1534 20.5441,54.7661 18.9149,59.196 18.6519,59.6798 18.3775,59.8366 18.1532,59.6598 17.9304,59.1655 17.7086,58.3754 17.4871,57.3097 17.265,55.9903 17.0423,54.4377 16.818,52.6729 16.5919,50.717 16.3629,48.5909 16.1309,46.3156 15.8951,43.9118 15.6551,41.4012 15.4103,38.8036 15.1599,36.141 14.9033,33.4344 14.6407,30.7043 14.3704,27.9718 14.0925,25.258 13.8063,22.5839 13.5114,19.9701 13.2069,17.438 12.8924,15.009 12.5674,12.7032 12.2313,10.5418 11.883,8.5458 11.5229,6.7363 11.1497,5.1345 10.7633,3.7615" /&gt;&lt;polygon style="fill:url(#id_#1429a2);stroke:none;" points="56.1668,56.8968 50.3457,52.9266 50.4902,52.9972 50.63,53.0141 50.7648,52.982 50.8965,52.9024 51.0238,52.7798 51.1481,52.6161 51.2686,52.4147 51.3872,52.1783 51.5027,51.9101 51.6164,51.6134 51.7283,51.2895 51.8385,50.9434 51.9478,50.5768 52.0561,50.1937 52.1639,49.7964 52.2717,49.3876 52.3797,48.9706 52.4881,48.5483 52.5974,48.1236 52.7074,47.7 52.8194,47.2798 52.9331,46.8666 53.049,46.4623 53.1667,46.0709 53.2883,45.6943 53.4119,45.3375 60,47.4093 59.8448,47.8561 59.6937,48.3264 59.5458,48.8158 59.4014,49.3208 59.2591,49.8379 59.1195,50.3633 58.9816,50.8925 58.845,51.4238 58.7092,51.9512 58.5744,52.4725 58.4398,52.9833 58.305,53.4804 58.1698,53.9597 58.033,54.4173 57.8951,54.8499 57.7555,55.2542 57.6133,55.6255 57.4686,55.9613 57.3209,56.2565 57.1694,56.5081 57.0146,56.713 56.8554,56.8663 56.6913,56.9653 56.5224,57.0062 56.3475,56.984" /&gt;&lt;polygon style="fill:url(#id_#28163F);stroke:none;" points="51.4421,42.8884 46.5659,41.7203 46.7028,41.8023 46.8376,41.9525 46.9702,42.1664 47.1013,42.4378 47.231,42.761 47.3586,43.131 47.485,43.5425 47.6101,43.9887 47.7331,44.4656 47.8552,44.9675 47.9761,45.488 48.0958,46.0228 48.2148,46.5658 48.3322,47.1106 48.4494,47.6533 48.5655,48.188 48.6806,48.7082 48.795,49.2094 48.9091,49.6863 49.0228,50.1321 49.1361,50.5433 49.2485,50.9129 49.3616,51.2355 49.5412,51.6837 49.7141,52.0613 49.8808,52.3714 50.0415,52.6172 50.1962,52.8009 50.3457,52.9266 56.1668,56.8968 55.98,56.7393 55.7863,56.5095 55.5857,56.2025 55.3774,55.8145 55.1615,55.3428 54.9367,54.7828 54.796,54.3789 54.6547,53.9171 54.5133,53.4035 54.3712,52.8463 54.2288,52.2499 54.0854,51.6235 53.9414,50.9728 53.7963,50.3052 53.6505,49.6264 53.503,48.9453 53.3548,48.2666 53.2051,47.5986 53.0539,46.9476 52.9015,46.3204 52.7472,45.7241 52.5913,45.1661 52.4332,44.6518 52.2736,44.1894 52.1118,43.7852 51.9481,43.446 51.7817,43.1788 51.6129,42.9908" /&gt;&lt;polygon style="fill:url(#id_#1429a2);stroke:none;" points="46.5072,55.376 42.6178,51.7104 42.8505,51.8235 43.0946,51.7695 43.3515,51.5269 43.6224,51.0766 43.9089,50.3965 44.2118,49.4669 44.5328,48.2673 44.873,46.7766 45.2338,44.9751 45.3918,44.1922 45.5468,43.528 45.6996,42.976 45.85,42.5312 45.9977,42.1879 46.143,41.9407 46.2862,41.784 46.4271,41.7127 46.5659,41.7203 51.4421,42.8884 51.2686,42.8787 51.0923,42.968 50.9139,43.1639 50.7321,43.473 50.5475,43.9021 50.3595,44.4587 50.1684,45.1481 49.9745,45.9788 49.7769,46.9562 49.326,49.2087 48.9008,51.0721 48.4993,52.5718 48.1208,53.7337 47.7629,54.5837 47.4244,55.1469 47.103,55.4494 46.7979,55.5179" /&gt;&lt;polygon style="fill:url(#id_#28163F);stroke:none;" points="42.7693,45.6178 39.6278,43.9039 39.843,44.061 40.0506,44.359 40.2515,44.7778 40.4475,45.2963 40.6388,45.8933 40.828,46.5502 41.015,47.2449 41.2027,47.9575 41.3909,48.6667 41.5816,49.3527 41.7764,49.9943 41.9763,50.5717 42.182,51.0638 42.3954,51.4504 42.6178,51.7104 46.5072,55.376 46.2289,55.0506 45.9622,54.5678 45.7048,53.9528 45.4555,53.2308 45.2122,52.4285 44.9734,51.5712 44.7381,50.6848 44.5038,49.7943 44.2696,48.9259 44.0336,48.1049 43.7941,47.358 43.5493,46.7098 43.2981,46.1868 43.0389,45.814" /&gt;&lt;polygon style="fill:url(#id_#1429a2);stroke:none;" points="37.2968,58.9458 35.2497,54.5661 35.4034,54.8741 35.5619,55.0825 35.7257,55.1839 35.8945,55.1721 36.0692,55.0399 36.2492,54.781 36.4354,54.3885 36.6279,53.8562 36.8266,53.1772 37.0321,52.3448 37.2442,51.3518 37.4635,50.1923 37.789,48.4808 38.0959,47.0746 38.3862,45.9539 38.6604,45.0973 38.9205,44.4843 39.1677,44.0949 39.403,43.9084 39.6278,43.9039 42.7693,45.6178 42.4887,45.6233 42.1944,45.857 41.8857,46.3439 41.5604,47.1099 41.2175,48.1807 40.8548,49.5814 40.4708,51.339 40.0643,53.4783 39.7901,54.9278 39.5249,56.1689 39.2682,57.2097 39.0199,58.059 38.7793,58.7239 38.5464,59.214 38.3212,59.5379 38.103,59.7034 37.8918,59.7179 37.6872,59.5912 37.4889,59.331" /&gt;&lt;polygon style="fill:url(#id_#28163F);stroke:none;" points="18.9149,59.196 20.5441,54.7661 20.7465,54.1348 20.9416,53.2765 21.1309,52.2081 21.3148,50.9479 21.4944,49.5115 21.6709,47.9184 21.845,46.1844 22.0182,44.3275 22.1908,42.3647 22.3646,40.3133 22.5398,38.1907 22.7176,36.0147 22.8994,33.8023 23.0856,31.5706 23.2776,29.3372 23.4763,27.1193 23.6825,24.9344 23.8976,22.7999 24.122,20.7326 24.3571,18.7501 24.604,16.87 24.8633,15.1097 25.136,13.4858 25.4234,12.0162 25.7263,10.7186 26.0457,9.6097 26.3825,8.7074 26.7381,8.028 27.1129,7.5891 27.5082,7.4095 27.811,7.4389 28.1009,7.5919 28.3782,7.8622 28.6434,8.2436 28.897,8.7289 29.1391,9.3117 29.3705,9.9866 29.5914,10.746 29.8025,11.5843 30.0038,12.4942 30.1959,13.4695 30.3792,14.5047 30.554,15.5915 30.7211,16.7254 30.8809,17.8987 31.0334,19.1055 31.1792,20.3387 31.3186,21.5923 31.4523,22.8601 31.5807,24.1355 31.7039,25.4116 31.8227,26.6825 31.9373,27.9413 32.0481,29.1818 32.1555,30.3977 32.26,31.5821 32.3622,32.7287 32.4623,33.8314 32.5607,34.8832 32.6577,35.878 32.7541,36.809 32.8501,37.6701 32.9535,38.5773 33.0575,39.5183 33.162,40.4857 33.2674,41.4735 33.3736,42.4744 33.4814,43.4823 33.5907,44.4902 33.7016,45.4922 33.8144,46.48 33.9295,47.4484 34.0471,48.3901 34.1672,49.2987 34.2902,50.1671 34.4164,50.9887 34.5457,51.7574 34.6785,52.4656 34.8151,53.1072 34.9556,53.6756 35.1004,54.1643 35.2497,54.5661 37.2968,58.9458 37.1103,58.4435 36.9294,57.833 36.7537,57.1225 36.583,56.3202 36.4168,55.4348 36.2552,54.474 36.0976,53.4468 35.9439,52.3617 35.7939,51.2258 35.6469,50.049 35.5031,48.8383 35.3619,47.6034 35.2232,46.3512 35.0866,45.0914 34.952,43.8312 34.819,42.58 34.6873,41.3454 34.5565,40.1361 34.4267,38.9601 34.2976,37.8262 34.1775,36.7495 34.0572,35.5855 33.9356,34.3416 33.8127,33.0267 33.6876,31.6489 33.5602,30.2153 33.4294,28.735 33.295,27.2152 33.1565,25.665 33.0132,24.0912 32.8648,22.5026 32.7107,20.9077 32.5502,19.3136 32.3831,17.7291 32.2088,16.1615 32.0266,14.6203 31.836,13.1113 31.6365,11.6452 31.4275,10.2275 31.2089,8.869 30.9797,7.5753 30.7395,6.3559 30.4879,5.2186 30.2242,4.1706 29.9481,3.2212 29.6587,2.3781 29.356,1.6492 29.0392,1.0425 28.7077,0.5659 28.3609,0.2281 27.9986,0.0363 27.6202,0 27.1258,0.225 26.6575,0.7729 26.2132,1.6219 25.7921,2.7505 25.3928,4.1367 25.0141,5.7586 24.6548,7.5957 24.3139,9.6253 23.9898,11.8255 23.6812,14.1759 23.3874,16.6537 23.1069,19.2378 22.8382,21.9059 22.5802,24.6374 22.3321,27.4097 22.092,30.2018 21.8591,32.9911 21.6319,35.7565 21.4095,38.4765 21.1904,41.1298 20.9735,43.6941 20.7575,46.1473 20.5414,48.4687 20.3235,50.636 20.1028,52.6279 19.8782,54.4228 19.6482,55.9983 19.412,57.3339 19.168,58.4069" /&gt;
&lt;/svg&gt;</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Nucleoplasm">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="G010228" name="IFN-beta" refUnificationXrefID="ref48;ref49;" type="cso30:c:mRNA">
<csml:entitySimulationProperty>
<csml:variable variableID="m93217" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="538.0" y="850.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="28.0" height="28.0" filePath="" fileType="internal" fileFormat="svg" outlineColor="0 0 0 0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" height="60.0" viewBox="0 0 60.0 60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;&lt;linearGradient xmlns:xlink="http://www.w3.org/1999/xlink" gradientTransform="" gradientUnits="objectBoundingBox" id="id_#ffd30f" spreadMethod="pad" x1="0%" x2="100%" y1="0%" y2="0%"&gt;&lt;stop offset="0%" style="stop-color:#ffd30f;stop-opacity:1;"/&gt;&lt;stop offset="100%" style="stop-color:#ffd30f;stop-opacity:1;"/&gt;&lt;/linearGradient&gt;&lt;linearGradient xmlns:xlink="http://www.w3.org/1999/xlink" gradientTransform="" gradientUnits="objectBoundingBox" id="id_#28163F" spreadMethod="pad" x1="0%" x2="100%" y1="0%" y2="0%"&gt;&lt;stop offset="0%" style="stop-color:#28163F;stop-opacity:1;"/&gt;&lt;stop offset="100%" style="stop-color:#28163F;stop-opacity:1;"/&gt;&lt;/linearGradient&gt;&lt;/defs&gt;&lt;polygon style="fill:url(#id_#28163F);stroke:none;" points="0,60 5.4121,55.4096 5.7389,55.06 6.0446,54.4747 6.3308,53.669 6.5988,52.6597 6.85,51.4625 7.086,50.0951 7.3084,48.5725 7.5185,46.9122 7.7176,45.1294 7.9075,43.2418 8.0893,41.2648 8.2647,39.2155 8.4352,37.1098 8.6021,34.9635 8.7669,32.7941 8.9312,30.6181 9.0962,28.4512 9.2635,26.3088 9.4348,24.2093 9.6113,22.1683 9.7943,20.2017 9.9856,18.3261 10.1866,16.5582 10.3987,14.9142 10.6231,13.4103 10.8617,12.0629 11.1155,10.8889 11.3866,9.9046 11.6759,9.1255 11.9852,8.5686 12.3157,8.2502 12.6689,8.1875 13.026,8.3869 13.3701,8.8365 13.702,9.519 10.3627,2.6373 9.9474,1.7838 9.5171,1.2214 9.0714,0.9722 8.6295,1.0511 8.2163,1.4488 7.8298,2.1448 7.4682,3.1188 7.1295,4.3492 6.812,5.8167 6.5139,7.5009 6.2331,9.3809 5.9681,11.4358 5.717,13.646 5.4777,15.9899 5.2488,18.4483 5.0285,20.9998 4.8145,23.6243 4.6051,26.3015 4.3989,29.0108 4.1935,31.7312 3.9875,34.443 3.7788,37.1246 3.5658,39.7578 3.3465,42.319 3.1191,44.7906 2.8818,47.1504 2.633,49.3783 2.3703,51.4539 2.0924,53.3568 1.7973,55.0662 1.4832,56.5624 1.1482,57.8244 0.7907,58.8315 0.4085,59.5636" /&gt;&lt;polygon style="fill:url(#id_#ffd30f);stroke:none;" points="10.3627,2.6373 13.702,9.519 14.0227,10.4186 14.3318,11.5175 14.6304,12.7984 14.9186,14.2465 15.197,15.8431 15.4659,17.5716 15.726,19.4163 15.9776,21.3597 16.2211,23.3859 16.4571,25.4767 16.6861,27.6164 16.9084,29.7868 17.1245,31.9728 17.335,34.1571 17.5402,36.3224 17.7404,38.4523 17.9361,40.5304 18.1283,42.5388 18.3167,44.4618 18.5024,46.2823 18.6855,47.9831 18.8666,49.5479 19.0458,50.9596 19.2242,52.2015 19.4018,53.2575 19.579,54.1096 19.7564,54.7419 19.9346,55.1368 20.114,55.2787 20.3337,55.1534 20.5441,54.7661 18.9149,59.196 18.6519,59.6798 18.3775,59.8366 18.1532,59.6598 17.9304,59.1655 17.7086,58.3754 17.4871,57.3097 17.265,55.9903 17.0423,54.4377 16.818,52.6729 16.5919,50.717 16.3629,48.5909 16.1309,46.3156 15.8951,43.9118 15.6551,41.4012 15.4103,38.8036 15.1599,36.141 14.9033,33.4344 14.6407,30.7043 14.3704,27.9718 14.0925,25.258 13.8063,22.5839 13.5114,19.9701 13.2069,17.438 12.8924,15.009 12.5674,12.7032 12.2313,10.5418 11.883,8.5458 11.5229,6.7363 11.1497,5.1345 10.7633,3.7615" /&gt;&lt;polygon style="fill:url(#id_#ffd30f);stroke:none;" points="56.1668,56.8968 50.3457,52.9266 50.4902,52.9972 50.63,53.0141 50.7648,52.982 50.8965,52.9024 51.0238,52.7798 51.1481,52.6161 51.2686,52.4147 51.3872,52.1783 51.5027,51.9101 51.6164,51.6134 51.7283,51.2895 51.8385,50.9434 51.9478,50.5768 52.0561,50.1937 52.1639,49.7964 52.2717,49.3876 52.3797,48.9706 52.4881,48.5483 52.5974,48.1236 52.7074,47.7 52.8194,47.2798 52.9331,46.8666 53.049,46.4623 53.1667,46.0709 53.2883,45.6943 53.4119,45.3375 60,47.4093 59.8448,47.8561 59.6937,48.3264 59.5458,48.8158 59.4014,49.3208 59.2591,49.8379 59.1195,50.3633 58.9816,50.8925 58.845,51.4238 58.7092,51.9512 58.5744,52.4725 58.4398,52.9833 58.305,53.4804 58.1698,53.9597 58.033,54.4173 57.8951,54.8499 57.7555,55.2542 57.6133,55.6255 57.4686,55.9613 57.3209,56.2565 57.1694,56.5081 57.0146,56.713 56.8554,56.8663 56.6913,56.9653 56.5224,57.0062 56.3475,56.984" /&gt;&lt;polygon style="fill:url(#id_#28163F);stroke:none;" points="51.4421,42.8884 46.5659,41.7203 46.7028,41.8023 46.8376,41.9525 46.9702,42.1664 47.1013,42.4378 47.231,42.761 47.3586,43.131 47.485,43.5425 47.6101,43.9887 47.7331,44.4656 47.8552,44.9675 47.9761,45.488 48.0958,46.0228 48.2148,46.5658 48.3322,47.1106 48.4494,47.6533 48.5655,48.188 48.6806,48.7082 48.795,49.2094 48.9091,49.6863 49.0228,50.1321 49.1361,50.5433 49.2485,50.9129 49.3616,51.2355 49.5412,51.6837 49.7141,52.0613 49.8808,52.3714 50.0415,52.6172 50.1962,52.8009 50.3457,52.9266 56.1668,56.8968 55.98,56.7393 55.7863,56.5095 55.5857,56.2025 55.3774,55.8145 55.1615,55.3428 54.9367,54.7828 54.796,54.3789 54.6547,53.9171 54.5133,53.4035 54.3712,52.8463 54.2288,52.2499 54.0854,51.6235 53.9414,50.9728 53.7963,50.3052 53.6505,49.6264 53.503,48.9453 53.3548,48.2666 53.2051,47.5986 53.0539,46.9476 52.9015,46.3204 52.7472,45.7241 52.5913,45.1661 52.4332,44.6518 52.2736,44.1894 52.1118,43.7852 51.9481,43.446 51.7817,43.1788 51.6129,42.9908" /&gt;&lt;polygon style="fill:url(#id_#ffd30f);stroke:none;" points="46.5072,55.376 42.6178,51.7104 42.8505,51.8235 43.0946,51.7695 43.3515,51.5269 43.6224,51.0766 43.9089,50.3965 44.2118,49.4669 44.5328,48.2673 44.873,46.7766 45.2338,44.9751 45.3918,44.1922 45.5468,43.528 45.6996,42.976 45.85,42.5312 45.9977,42.1879 46.143,41.9407 46.2862,41.784 46.4271,41.7127 46.5659,41.7203 51.4421,42.8884 51.2686,42.8787 51.0923,42.968 50.9139,43.1639 50.7321,43.473 50.5475,43.9021 50.3595,44.4587 50.1684,45.1481 49.9745,45.9788 49.7769,46.9562 49.326,49.2087 48.9008,51.0721 48.4993,52.5718 48.1208,53.7337 47.7629,54.5837 47.4244,55.1469 47.103,55.4494 46.7979,55.5179" /&gt;&lt;polygon style="fill:url(#id_#28163F);stroke:none;" points="42.7693,45.6178 39.6278,43.9039 39.843,44.061 40.0506,44.359 40.2515,44.7778 40.4475,45.2963 40.6388,45.8933 40.828,46.5502 41.015,47.2449 41.2027,47.9575 41.3909,48.6667 41.5816,49.3527 41.7764,49.9943 41.9763,50.5717 42.182,51.0638 42.3954,51.4504 42.6178,51.7104 46.5072,55.376 46.2289,55.0506 45.9622,54.5678 45.7048,53.9528 45.4555,53.2308 45.2122,52.4285 44.9734,51.5712 44.7381,50.6848 44.5038,49.7943 44.2696,48.9259 44.0336,48.1049 43.7941,47.358 43.5493,46.7098 43.2981,46.1868 43.0389,45.814" /&gt;&lt;polygon style="fill:url(#id_#ffd30f);stroke:none;" points="37.2968,58.9458 35.2497,54.5661 35.4034,54.8741 35.5619,55.0825 35.7257,55.1839 35.8945,55.1721 36.0692,55.0399 36.2492,54.781 36.4354,54.3885 36.6279,53.8562 36.8266,53.1772 37.0321,52.3448 37.2442,51.3518 37.4635,50.1923 37.789,48.4808 38.0959,47.0746 38.3862,45.9539 38.6604,45.0973 38.9205,44.4843 39.1677,44.0949 39.403,43.9084 39.6278,43.9039 42.7693,45.6178 42.4887,45.6233 42.1944,45.857 41.8857,46.3439 41.5604,47.1099 41.2175,48.1807 40.8548,49.5814 40.4708,51.339 40.0643,53.4783 39.7901,54.9278 39.5249,56.1689 39.2682,57.2097 39.0199,58.059 38.7793,58.7239 38.5464,59.214 38.3212,59.5379 38.103,59.7034 37.8918,59.7179 37.6872,59.5912 37.4889,59.331" /&gt;&lt;polygon style="fill:url(#id_#28163F);stroke:none;" points="18.9149,59.196 20.5441,54.7661 20.7465,54.1348 20.9416,53.2765 21.1309,52.2081 21.3148,50.9479 21.4944,49.5115 21.6709,47.9184 21.845,46.1844 22.0182,44.3275 22.1908,42.3647 22.3646,40.3133 22.5398,38.1907 22.7176,36.0147 22.8994,33.8023 23.0856,31.5706 23.2776,29.3372 23.4763,27.1193 23.6825,24.9344 23.8976,22.7999 24.122,20.7326 24.3571,18.7501 24.604,16.87 24.8633,15.1097 25.136,13.4858 25.4234,12.0162 25.7263,10.7186 26.0457,9.6097 26.3825,8.7074 26.7381,8.028 27.1129,7.5891 27.5082,7.4095 27.811,7.4389 28.1009,7.5919 28.3782,7.8622 28.6434,8.2436 28.897,8.7289 29.1391,9.3117 29.3705,9.9866 29.5914,10.746 29.8025,11.5843 30.0038,12.4942 30.1959,13.4695 30.3792,14.5047 30.554,15.5915 30.7211,16.7254 30.8809,17.8987 31.0334,19.1055 31.1792,20.3387 31.3186,21.5923 31.4523,22.8601 31.5807,24.1355 31.7039,25.4116 31.8227,26.6825 31.9373,27.9413 32.0481,29.1818 32.1555,30.3977 32.26,31.5821 32.3622,32.7287 32.4623,33.8314 32.5607,34.8832 32.6577,35.878 32.7541,36.809 32.8501,37.6701 32.9535,38.5773 33.0575,39.5183 33.162,40.4857 33.2674,41.4735 33.3736,42.4744 33.4814,43.4823 33.5907,44.4902 33.7016,45.4922 33.8144,46.48 33.9295,47.4484 34.0471,48.3901 34.1672,49.2987 34.2902,50.1671 34.4164,50.9887 34.5457,51.7574 34.6785,52.4656 34.8151,53.1072 34.9556,53.6756 35.1004,54.1643 35.2497,54.5661 37.2968,58.9458 37.1103,58.4435 36.9294,57.833 36.7537,57.1225 36.583,56.3202 36.4168,55.4348 36.2552,54.474 36.0976,53.4468 35.9439,52.3617 35.7939,51.2258 35.6469,50.049 35.5031,48.8383 35.3619,47.6034 35.2232,46.3512 35.0866,45.0914 34.952,43.8312 34.819,42.58 34.6873,41.3454 34.5565,40.1361 34.4267,38.9601 34.2976,37.8262 34.1775,36.7495 34.0572,35.5855 33.9356,34.3416 33.8127,33.0267 33.6876,31.6489 33.5602,30.2153 33.4294,28.735 33.295,27.2152 33.1565,25.665 33.0132,24.0912 32.8648,22.5026 32.7107,20.9077 32.5502,19.3136 32.3831,17.7291 32.2088,16.1615 32.0266,14.6203 31.836,13.1113 31.6365,11.6452 31.4275,10.2275 31.2089,8.869 30.9797,7.5753 30.7395,6.3559 30.4879,5.2186 30.2242,4.1706 29.9481,3.2212 29.6587,2.3781 29.356,1.6492 29.0392,1.0425 28.7077,0.5659 28.3609,0.2281 27.9986,0.0363 27.6202,0 27.1258,0.225 26.6575,0.7729 26.2132,1.6219 25.7921,2.7505 25.3928,4.1367 25.0141,5.7586 24.6548,7.5957 24.3139,9.6253 23.9898,11.8255 23.6812,14.1759 23.3874,16.6537 23.1069,19.2378 22.8382,21.9059 22.5802,24.6374 22.3321,27.4097 22.092,30.2018 21.8591,32.9911 21.6319,35.7565 21.4095,38.4765 21.1904,41.1298 20.9735,43.6941 20.7575,46.1473 20.5414,48.4687 20.3235,50.636 20.1028,52.6279 19.8782,54.4228 19.6482,55.9983 19.412,57.3339 19.168,58.4069" /&gt;
&lt;/svg&gt;</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Nucleoplasm">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="G010657" name="IL-12 p40" refUnificationXrefID="ref50;ref51;" type="cso30:c:mRNA">
<csml:entitySimulationProperty>
<csml:variable variableID="m93589" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="401.0" y="829.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="22.0" height="22.0" filePath="" fileType="internal" fileFormat="svg" outlineColor="0 0 0 0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" height="60.0" viewBox="0 0 60.0 60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;&lt;linearGradient xmlns:xlink="http://www.w3.org/1999/xlink" gradientTransform="" gradientUnits="objectBoundingBox" id="id_#ffd30f" spreadMethod="pad" x1="0%" x2="100%" y1="0%" y2="0%"&gt;&lt;stop offset="0%" style="stop-color:#ffd30f;stop-opacity:1;"/&gt;&lt;stop offset="100%" style="stop-color:#ffd30f;stop-opacity:1;"/&gt;&lt;/linearGradient&gt;&lt;linearGradient xmlns:xlink="http://www.w3.org/1999/xlink" gradientTransform="" gradientUnits="objectBoundingBox" id="id_#28163F" spreadMethod="pad" x1="0%" x2="100%" y1="0%" y2="0%"&gt;&lt;stop offset="0%" style="stop-color:#28163F;stop-opacity:1;"/&gt;&lt;stop offset="100%" style="stop-color:#28163F;stop-opacity:1;"/&gt;&lt;/linearGradient&gt;&lt;/defs&gt;&lt;polygon style="fill:url(#id_#28163F);stroke:none;" points="0,60 5.4121,55.4096 5.7389,55.06 6.0446,54.4747 6.3308,53.669 6.5988,52.6597 6.85,51.4625 7.086,50.0951 7.3084,48.5725 7.5185,46.9122 7.7176,45.1294 7.9075,43.2418 8.0893,41.2648 8.2647,39.2155 8.4352,37.1098 8.6021,34.9635 8.7669,32.7941 8.9312,30.6181 9.0962,28.4512 9.2635,26.3088 9.4348,24.2093 9.6113,22.1683 9.7943,20.2017 9.9856,18.3261 10.1866,16.5582 10.3987,14.9142 10.6231,13.4103 10.8617,12.0629 11.1155,10.8889 11.3866,9.9046 11.6759,9.1255 11.9852,8.5686 12.3157,8.2502 12.6689,8.1875 13.026,8.3869 13.3701,8.8365 13.702,9.519 10.3627,2.6373 9.9474,1.7838 9.5171,1.2214 9.0714,0.9722 8.6295,1.0511 8.2163,1.4488 7.8298,2.1448 7.4682,3.1188 7.1295,4.3492 6.812,5.8167 6.5139,7.5009 6.2331,9.3809 5.9681,11.4358 5.717,13.646 5.4777,15.9899 5.2488,18.4483 5.0285,20.9998 4.8145,23.6243 4.6051,26.3015 4.3989,29.0108 4.1935,31.7312 3.9875,34.443 3.7788,37.1246 3.5658,39.7578 3.3465,42.319 3.1191,44.7906 2.8818,47.1504 2.633,49.3783 2.3703,51.4539 2.0924,53.3568 1.7973,55.0662 1.4832,56.5624 1.1482,57.8244 0.7907,58.8315 0.4085,59.5636" /&gt;&lt;polygon style="fill:url(#id_#ffd30f);stroke:none;" points="10.3627,2.6373 13.702,9.519 14.0227,10.4186 14.3318,11.5175 14.6304,12.7984 14.9186,14.2465 15.197,15.8431 15.4659,17.5716 15.726,19.4163 15.9776,21.3597 16.2211,23.3859 16.4571,25.4767 16.6861,27.6164 16.9084,29.7868 17.1245,31.9728 17.335,34.1571 17.5402,36.3224 17.7404,38.4523 17.9361,40.5304 18.1283,42.5388 18.3167,44.4618 18.5024,46.2823 18.6855,47.9831 18.8666,49.5479 19.0458,50.9596 19.2242,52.2015 19.4018,53.2575 19.579,54.1096 19.7564,54.7419 19.9346,55.1368 20.114,55.2787 20.3337,55.1534 20.5441,54.7661 18.9149,59.196 18.6519,59.6798 18.3775,59.8366 18.1532,59.6598 17.9304,59.1655 17.7086,58.3754 17.4871,57.3097 17.265,55.9903 17.0423,54.4377 16.818,52.6729 16.5919,50.717 16.3629,48.5909 16.1309,46.3156 15.8951,43.9118 15.6551,41.4012 15.4103,38.8036 15.1599,36.141 14.9033,33.4344 14.6407,30.7043 14.3704,27.9718 14.0925,25.258 13.8063,22.5839 13.5114,19.9701 13.2069,17.438 12.8924,15.009 12.5674,12.7032 12.2313,10.5418 11.883,8.5458 11.5229,6.7363 11.1497,5.1345 10.7633,3.7615" /&gt;&lt;polygon style="fill:url(#id_#ffd30f);stroke:none;" points="56.1668,56.8968 50.3457,52.9266 50.4902,52.9972 50.63,53.0141 50.7648,52.982 50.8965,52.9024 51.0238,52.7798 51.1481,52.6161 51.2686,52.4147 51.3872,52.1783 51.5027,51.9101 51.6164,51.6134 51.7283,51.2895 51.8385,50.9434 51.9478,50.5768 52.0561,50.1937 52.1639,49.7964 52.2717,49.3876 52.3797,48.9706 52.4881,48.5483 52.5974,48.1236 52.7074,47.7 52.8194,47.2798 52.9331,46.8666 53.049,46.4623 53.1667,46.0709 53.2883,45.6943 53.4119,45.3375 60,47.4093 59.8448,47.8561 59.6937,48.3264 59.5458,48.8158 59.4014,49.3208 59.2591,49.8379 59.1195,50.3633 58.9816,50.8925 58.845,51.4238 58.7092,51.9512 58.5744,52.4725 58.4398,52.9833 58.305,53.4804 58.1698,53.9597 58.033,54.4173 57.8951,54.8499 57.7555,55.2542 57.6133,55.6255 57.4686,55.9613 57.3209,56.2565 57.1694,56.5081 57.0146,56.713 56.8554,56.8663 56.6913,56.9653 56.5224,57.0062 56.3475,56.984" /&gt;&lt;polygon style="fill:url(#id_#28163F);stroke:none;" points="51.4421,42.8884 46.5659,41.7203 46.7028,41.8023 46.8376,41.9525 46.9702,42.1664 47.1013,42.4378 47.231,42.761 47.3586,43.131 47.485,43.5425 47.6101,43.9887 47.7331,44.4656 47.8552,44.9675 47.9761,45.488 48.0958,46.0228 48.2148,46.5658 48.3322,47.1106 48.4494,47.6533 48.5655,48.188 48.6806,48.7082 48.795,49.2094 48.9091,49.6863 49.0228,50.1321 49.1361,50.5433 49.2485,50.9129 49.3616,51.2355 49.5412,51.6837 49.7141,52.0613 49.8808,52.3714 50.0415,52.6172 50.1962,52.8009 50.3457,52.9266 56.1668,56.8968 55.98,56.7393 55.7863,56.5095 55.5857,56.2025 55.3774,55.8145 55.1615,55.3428 54.9367,54.7828 54.796,54.3789 54.6547,53.9171 54.5133,53.4035 54.3712,52.8463 54.2288,52.2499 54.0854,51.6235 53.9414,50.9728 53.7963,50.3052 53.6505,49.6264 53.503,48.9453 53.3548,48.2666 53.2051,47.5986 53.0539,46.9476 52.9015,46.3204 52.7472,45.7241 52.5913,45.1661 52.4332,44.6518 52.2736,44.1894 52.1118,43.7852 51.9481,43.446 51.7817,43.1788 51.6129,42.9908" /&gt;&lt;polygon style="fill:url(#id_#ffd30f);stroke:none;" points="46.5072,55.376 42.6178,51.7104 42.8505,51.8235 43.0946,51.7695 43.3515,51.5269 43.6224,51.0766 43.9089,50.3965 44.2118,49.4669 44.5328,48.2673 44.873,46.7766 45.2338,44.9751 45.3918,44.1922 45.5468,43.528 45.6996,42.976 45.85,42.5312 45.9977,42.1879 46.143,41.9407 46.2862,41.784 46.4271,41.7127 46.5659,41.7203 51.4421,42.8884 51.2686,42.8787 51.0923,42.968 50.9139,43.1639 50.7321,43.473 50.5475,43.9021 50.3595,44.4587 50.1684,45.1481 49.9745,45.9788 49.7769,46.9562 49.326,49.2087 48.9008,51.0721 48.4993,52.5718 48.1208,53.7337 47.7629,54.5837 47.4244,55.1469 47.103,55.4494 46.7979,55.5179" /&gt;&lt;polygon style="fill:url(#id_#28163F);stroke:none;" points="42.7693,45.6178 39.6278,43.9039 39.843,44.061 40.0506,44.359 40.2515,44.7778 40.4475,45.2963 40.6388,45.8933 40.828,46.5502 41.015,47.2449 41.2027,47.9575 41.3909,48.6667 41.5816,49.3527 41.7764,49.9943 41.9763,50.5717 42.182,51.0638 42.3954,51.4504 42.6178,51.7104 46.5072,55.376 46.2289,55.0506 45.9622,54.5678 45.7048,53.9528 45.4555,53.2308 45.2122,52.4285 44.9734,51.5712 44.7381,50.6848 44.5038,49.7943 44.2696,48.9259 44.0336,48.1049 43.7941,47.358 43.5493,46.7098 43.2981,46.1868 43.0389,45.814" /&gt;&lt;polygon style="fill:url(#id_#ffd30f);stroke:none;" points="37.2968,58.9458 35.2497,54.5661 35.4034,54.8741 35.5619,55.0825 35.7257,55.1839 35.8945,55.1721 36.0692,55.0399 36.2492,54.781 36.4354,54.3885 36.6279,53.8562 36.8266,53.1772 37.0321,52.3448 37.2442,51.3518 37.4635,50.1923 37.789,48.4808 38.0959,47.0746 38.3862,45.9539 38.6604,45.0973 38.9205,44.4843 39.1677,44.0949 39.403,43.9084 39.6278,43.9039 42.7693,45.6178 42.4887,45.6233 42.1944,45.857 41.8857,46.3439 41.5604,47.1099 41.2175,48.1807 40.8548,49.5814 40.4708,51.339 40.0643,53.4783 39.7901,54.9278 39.5249,56.1689 39.2682,57.2097 39.0199,58.059 38.7793,58.7239 38.5464,59.214 38.3212,59.5379 38.103,59.7034 37.8918,59.7179 37.6872,59.5912 37.4889,59.331" /&gt;&lt;polygon style="fill:url(#id_#28163F);stroke:none;" points="18.9149,59.196 20.5441,54.7661 20.7465,54.1348 20.9416,53.2765 21.1309,52.2081 21.3148,50.9479 21.4944,49.5115 21.6709,47.9184 21.845,46.1844 22.0182,44.3275 22.1908,42.3647 22.3646,40.3133 22.5398,38.1907 22.7176,36.0147 22.8994,33.8023 23.0856,31.5706 23.2776,29.3372 23.4763,27.1193 23.6825,24.9344 23.8976,22.7999 24.122,20.7326 24.3571,18.7501 24.604,16.87 24.8633,15.1097 25.136,13.4858 25.4234,12.0162 25.7263,10.7186 26.0457,9.6097 26.3825,8.7074 26.7381,8.028 27.1129,7.5891 27.5082,7.4095 27.811,7.4389 28.1009,7.5919 28.3782,7.8622 28.6434,8.2436 28.897,8.7289 29.1391,9.3117 29.3705,9.9866 29.5914,10.746 29.8025,11.5843 30.0038,12.4942 30.1959,13.4695 30.3792,14.5047 30.554,15.5915 30.7211,16.7254 30.8809,17.8987 31.0334,19.1055 31.1792,20.3387 31.3186,21.5923 31.4523,22.8601 31.5807,24.1355 31.7039,25.4116 31.8227,26.6825 31.9373,27.9413 32.0481,29.1818 32.1555,30.3977 32.26,31.5821 32.3622,32.7287 32.4623,33.8314 32.5607,34.8832 32.6577,35.878 32.7541,36.809 32.8501,37.6701 32.9535,38.5773 33.0575,39.5183 33.162,40.4857 33.2674,41.4735 33.3736,42.4744 33.4814,43.4823 33.5907,44.4902 33.7016,45.4922 33.8144,46.48 33.9295,47.4484 34.0471,48.3901 34.1672,49.2987 34.2902,50.1671 34.4164,50.9887 34.5457,51.7574 34.6785,52.4656 34.8151,53.1072 34.9556,53.6756 35.1004,54.1643 35.2497,54.5661 37.2968,58.9458 37.1103,58.4435 36.9294,57.833 36.7537,57.1225 36.583,56.3202 36.4168,55.4348 36.2552,54.474 36.0976,53.4468 35.9439,52.3617 35.7939,51.2258 35.6469,50.049 35.5031,48.8383 35.3619,47.6034 35.2232,46.3512 35.0866,45.0914 34.952,43.8312 34.819,42.58 34.6873,41.3454 34.5565,40.1361 34.4267,38.9601 34.2976,37.8262 34.1775,36.7495 34.0572,35.5855 33.9356,34.3416 33.8127,33.0267 33.6876,31.6489 33.5602,30.2153 33.4294,28.735 33.295,27.2152 33.1565,25.665 33.0132,24.0912 32.8648,22.5026 32.7107,20.9077 32.5502,19.3136 32.3831,17.7291 32.2088,16.1615 32.0266,14.6203 31.836,13.1113 31.6365,11.6452 31.4275,10.2275 31.2089,8.869 30.9797,7.5753 30.7395,6.3559 30.4879,5.2186 30.2242,4.1706 29.9481,3.2212 29.6587,2.3781 29.356,1.6492 29.0392,1.0425 28.7077,0.5659 28.3609,0.2281 27.9986,0.0363 27.6202,0 27.1258,0.225 26.6575,0.7729 26.2132,1.6219 25.7921,2.7505 25.3928,4.1367 25.0141,5.7586 24.6548,7.5957 24.3139,9.6253 23.9898,11.8255 23.6812,14.1759 23.3874,16.6537 23.1069,19.2378 22.8382,21.9059 22.5802,24.6374 22.3321,27.4097 22.092,30.2018 21.8591,32.9911 21.6319,35.7565 21.4095,38.4765 21.1904,41.1298 20.9735,43.6941 20.7575,46.1473 20.5414,48.4687 20.3235,50.636 20.1028,52.6279 19.8782,54.4228 19.6482,55.9983 19.412,57.3339 19.168,58.4069" /&gt;
&lt;/svg&gt;</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="G010329" name="TNF-alpha" refUnificationXrefID="ref52;ref53;" type="cso30:c:mRNA">
<csml:entitySimulationProperty>
<csml:variable variableID="m93309" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="414.0" y="958.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="28.0" height="28.0" filePath="" fileType="internal" fileFormat="svg" outlineColor="0 0 0 0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" height="60.0" viewBox="0 0 60.0 60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;&lt;linearGradient xmlns:xlink="http://www.w3.org/1999/xlink" gradientTransform="" gradientUnits="objectBoundingBox" id="id_#31861c" spreadMethod="pad" x1="0%" x2="100%" y1="0%" y2="0%"&gt;&lt;stop offset="0%" style="stop-color:#31861c;stop-opacity:1;"/&gt;&lt;stop offset="100%" style="stop-color:#31861c;stop-opacity:1;"/&gt;&lt;/linearGradient&gt;&lt;linearGradient xmlns:xlink="http://www.w3.org/1999/xlink" gradientTransform="" gradientUnits="objectBoundingBox" id="id_#28163F" spreadMethod="pad" x1="0%" x2="100%" y1="0%" y2="0%"&gt;&lt;stop offset="0%" style="stop-color:#28163F;stop-opacity:1;"/&gt;&lt;stop offset="100%" style="stop-color:#28163F;stop-opacity:1;"/&gt;&lt;/linearGradient&gt;&lt;/defs&gt;&lt;polygon style="fill:url(#id_#28163F);stroke:none;" points="0,60 5.4121,55.4096 5.7389,55.06 6.0446,54.4747 6.3308,53.669 6.5988,52.6597 6.85,51.4625 7.086,50.0951 7.3084,48.5725 7.5185,46.9122 7.7176,45.1294 7.9075,43.2418 8.0893,41.2648 8.2647,39.2155 8.4352,37.1098 8.6021,34.9635 8.7669,32.7941 8.9312,30.6181 9.0962,28.4512 9.2635,26.3088 9.4348,24.2093 9.6113,22.1683 9.7943,20.2017 9.9856,18.3261 10.1866,16.5582 10.3987,14.9142 10.6231,13.4103 10.8617,12.0629 11.1155,10.8889 11.3866,9.9046 11.6759,9.1255 11.9852,8.5686 12.3157,8.2502 12.6689,8.1875 13.026,8.3869 13.3701,8.8365 13.702,9.519 10.3627,2.6373 9.9474,1.7838 9.5171,1.2214 9.0714,0.9722 8.6295,1.0511 8.2163,1.4488 7.8298,2.1448 7.4682,3.1188 7.1295,4.3492 6.812,5.8167 6.5139,7.5009 6.2331,9.3809 5.9681,11.4358 5.717,13.646 5.4777,15.9899 5.2488,18.4483 5.0285,20.9998 4.8145,23.6243 4.6051,26.3015 4.3989,29.0108 4.1935,31.7312 3.9875,34.443 3.7788,37.1246 3.5658,39.7578 3.3465,42.319 3.1191,44.7906 2.8818,47.1504 2.633,49.3783 2.3703,51.4539 2.0924,53.3568 1.7973,55.0662 1.4832,56.5624 1.1482,57.8244 0.7907,58.8315 0.4085,59.5636" /&gt;&lt;polygon style="fill:url(#id_#31861c);stroke:none;" points="10.3627,2.6373 13.702,9.519 14.0227,10.4186 14.3318,11.5175 14.6304,12.7984 14.9186,14.2465 15.197,15.8431 15.4659,17.5716 15.726,19.4163 15.9776,21.3597 16.2211,23.3859 16.4571,25.4767 16.6861,27.6164 16.9084,29.7868 17.1245,31.9728 17.335,34.1571 17.5402,36.3224 17.7404,38.4523 17.9361,40.5304 18.1283,42.5388 18.3167,44.4618 18.5024,46.2823 18.6855,47.9831 18.8666,49.5479 19.0458,50.9596 19.2242,52.2015 19.4018,53.2575 19.579,54.1096 19.7564,54.7419 19.9346,55.1368 20.114,55.2787 20.3337,55.1534 20.5441,54.7661 18.9149,59.196 18.6519,59.6798 18.3775,59.8366 18.1532,59.6598 17.9304,59.1655 17.7086,58.3754 17.4871,57.3097 17.265,55.9903 17.0423,54.4377 16.818,52.6729 16.5919,50.717 16.3629,48.5909 16.1309,46.3156 15.8951,43.9118 15.6551,41.4012 15.4103,38.8036 15.1599,36.141 14.9033,33.4344 14.6407,30.7043 14.3704,27.9718 14.0925,25.258 13.8063,22.5839 13.5114,19.9701 13.2069,17.438 12.8924,15.009 12.5674,12.7032 12.2313,10.5418 11.883,8.5458 11.5229,6.7363 11.1497,5.1345 10.7633,3.7615" /&gt;&lt;polygon style="fill:url(#id_#31861c);stroke:none;" points="56.1668,56.8968 50.3457,52.9266 50.4902,52.9972 50.63,53.0141 50.7648,52.982 50.8965,52.9024 51.0238,52.7798 51.1481,52.6161 51.2686,52.4147 51.3872,52.1783 51.5027,51.9101 51.6164,51.6134 51.7283,51.2895 51.8385,50.9434 51.9478,50.5768 52.0561,50.1937 52.1639,49.7964 52.2717,49.3876 52.3797,48.9706 52.4881,48.5483 52.5974,48.1236 52.7074,47.7 52.8194,47.2798 52.9331,46.8666 53.049,46.4623 53.1667,46.0709 53.2883,45.6943 53.4119,45.3375 60,47.4093 59.8448,47.8561 59.6937,48.3264 59.5458,48.8158 59.4014,49.3208 59.2591,49.8379 59.1195,50.3633 58.9816,50.8925 58.845,51.4238 58.7092,51.9512 58.5744,52.4725 58.4398,52.9833 58.305,53.4804 58.1698,53.9597 58.033,54.4173 57.8951,54.8499 57.7555,55.2542 57.6133,55.6255 57.4686,55.9613 57.3209,56.2565 57.1694,56.5081 57.0146,56.713 56.8554,56.8663 56.6913,56.9653 56.5224,57.0062 56.3475,56.984" /&gt;&lt;polygon style="fill:url(#id_#28163F);stroke:none;" points="51.4421,42.8884 46.5659,41.7203 46.7028,41.8023 46.8376,41.9525 46.9702,42.1664 47.1013,42.4378 47.231,42.761 47.3586,43.131 47.485,43.5425 47.6101,43.9887 47.7331,44.4656 47.8552,44.9675 47.9761,45.488 48.0958,46.0228 48.2148,46.5658 48.3322,47.1106 48.4494,47.6533 48.5655,48.188 48.6806,48.7082 48.795,49.2094 48.9091,49.6863 49.0228,50.1321 49.1361,50.5433 49.2485,50.9129 49.3616,51.2355 49.5412,51.6837 49.7141,52.0613 49.8808,52.3714 50.0415,52.6172 50.1962,52.8009 50.3457,52.9266 56.1668,56.8968 55.98,56.7393 55.7863,56.5095 55.5857,56.2025 55.3774,55.8145 55.1615,55.3428 54.9367,54.7828 54.796,54.3789 54.6547,53.9171 54.5133,53.4035 54.3712,52.8463 54.2288,52.2499 54.0854,51.6235 53.9414,50.9728 53.7963,50.3052 53.6505,49.6264 53.503,48.9453 53.3548,48.2666 53.2051,47.5986 53.0539,46.9476 52.9015,46.3204 52.7472,45.7241 52.5913,45.1661 52.4332,44.6518 52.2736,44.1894 52.1118,43.7852 51.9481,43.446 51.7817,43.1788 51.6129,42.9908" /&gt;&lt;polygon style="fill:url(#id_#31861c);stroke:none;" points="46.5072,55.376 42.6178,51.7104 42.8505,51.8235 43.0946,51.7695 43.3515,51.5269 43.6224,51.0766 43.9089,50.3965 44.2118,49.4669 44.5328,48.2673 44.873,46.7766 45.2338,44.9751 45.3918,44.1922 45.5468,43.528 45.6996,42.976 45.85,42.5312 45.9977,42.1879 46.143,41.9407 46.2862,41.784 46.4271,41.7127 46.5659,41.7203 51.4421,42.8884 51.2686,42.8787 51.0923,42.968 50.9139,43.1639 50.7321,43.473 50.5475,43.9021 50.3595,44.4587 50.1684,45.1481 49.9745,45.9788 49.7769,46.9562 49.326,49.2087 48.9008,51.0721 48.4993,52.5718 48.1208,53.7337 47.7629,54.5837 47.4244,55.1469 47.103,55.4494 46.7979,55.5179" /&gt;&lt;polygon style="fill:url(#id_#28163F);stroke:none;" points="42.7693,45.6178 39.6278,43.9039 39.843,44.061 40.0506,44.359 40.2515,44.7778 40.4475,45.2963 40.6388,45.8933 40.828,46.5502 41.015,47.2449 41.2027,47.9575 41.3909,48.6667 41.5816,49.3527 41.7764,49.9943 41.9763,50.5717 42.182,51.0638 42.3954,51.4504 42.6178,51.7104 46.5072,55.376 46.2289,55.0506 45.9622,54.5678 45.7048,53.9528 45.4555,53.2308 45.2122,52.4285 44.9734,51.5712 44.7381,50.6848 44.5038,49.7943 44.2696,48.9259 44.0336,48.1049 43.7941,47.358 43.5493,46.7098 43.2981,46.1868 43.0389,45.814" /&gt;&lt;polygon style="fill:url(#id_#31861c);stroke:none;" points="37.2968,58.9458 35.2497,54.5661 35.4034,54.8741 35.5619,55.0825 35.7257,55.1839 35.8945,55.1721 36.0692,55.0399 36.2492,54.781 36.4354,54.3885 36.6279,53.8562 36.8266,53.1772 37.0321,52.3448 37.2442,51.3518 37.4635,50.1923 37.789,48.4808 38.0959,47.0746 38.3862,45.9539 38.6604,45.0973 38.9205,44.4843 39.1677,44.0949 39.403,43.9084 39.6278,43.9039 42.7693,45.6178 42.4887,45.6233 42.1944,45.857 41.8857,46.3439 41.5604,47.1099 41.2175,48.1807 40.8548,49.5814 40.4708,51.339 40.0643,53.4783 39.7901,54.9278 39.5249,56.1689 39.2682,57.2097 39.0199,58.059 38.7793,58.7239 38.5464,59.214 38.3212,59.5379 38.103,59.7034 37.8918,59.7179 37.6872,59.5912 37.4889,59.331" /&gt;&lt;polygon style="fill:url(#id_#28163F);stroke:none;" points="18.9149,59.196 20.5441,54.7661 20.7465,54.1348 20.9416,53.2765 21.1309,52.2081 21.3148,50.9479 21.4944,49.5115 21.6709,47.9184 21.845,46.1844 22.0182,44.3275 22.1908,42.3647 22.3646,40.3133 22.5398,38.1907 22.7176,36.0147 22.8994,33.8023 23.0856,31.5706 23.2776,29.3372 23.4763,27.1193 23.6825,24.9344 23.8976,22.7999 24.122,20.7326 24.3571,18.7501 24.604,16.87 24.8633,15.1097 25.136,13.4858 25.4234,12.0162 25.7263,10.7186 26.0457,9.6097 26.3825,8.7074 26.7381,8.028 27.1129,7.5891 27.5082,7.4095 27.811,7.4389 28.1009,7.5919 28.3782,7.8622 28.6434,8.2436 28.897,8.7289 29.1391,9.3117 29.3705,9.9866 29.5914,10.746 29.8025,11.5843 30.0038,12.4942 30.1959,13.4695 30.3792,14.5047 30.554,15.5915 30.7211,16.7254 30.8809,17.8987 31.0334,19.1055 31.1792,20.3387 31.3186,21.5923 31.4523,22.8601 31.5807,24.1355 31.7039,25.4116 31.8227,26.6825 31.9373,27.9413 32.0481,29.1818 32.1555,30.3977 32.26,31.5821 32.3622,32.7287 32.4623,33.8314 32.5607,34.8832 32.6577,35.878 32.7541,36.809 32.8501,37.6701 32.9535,38.5773 33.0575,39.5183 33.162,40.4857 33.2674,41.4735 33.3736,42.4744 33.4814,43.4823 33.5907,44.4902 33.7016,45.4922 33.8144,46.48 33.9295,47.4484 34.0471,48.3901 34.1672,49.2987 34.2902,50.1671 34.4164,50.9887 34.5457,51.7574 34.6785,52.4656 34.8151,53.1072 34.9556,53.6756 35.1004,54.1643 35.2497,54.5661 37.2968,58.9458 37.1103,58.4435 36.9294,57.833 36.7537,57.1225 36.583,56.3202 36.4168,55.4348 36.2552,54.474 36.0976,53.4468 35.9439,52.3617 35.7939,51.2258 35.6469,50.049 35.5031,48.8383 35.3619,47.6034 35.2232,46.3512 35.0866,45.0914 34.952,43.8312 34.819,42.58 34.6873,41.3454 34.5565,40.1361 34.4267,38.9601 34.2976,37.8262 34.1775,36.7495 34.0572,35.5855 33.9356,34.3416 33.8127,33.0267 33.6876,31.6489 33.5602,30.2153 33.4294,28.735 33.295,27.2152 33.1565,25.665 33.0132,24.0912 32.8648,22.5026 32.7107,20.9077 32.5502,19.3136 32.3831,17.7291 32.2088,16.1615 32.0266,14.6203 31.836,13.1113 31.6365,11.6452 31.4275,10.2275 31.2089,8.869 30.9797,7.5753 30.7395,6.3559 30.4879,5.2186 30.2242,4.1706 29.9481,3.2212 29.6587,2.3781 29.356,1.6492 29.0392,1.0425 28.7077,0.5659 28.3609,0.2281 27.9986,0.0363 27.6202,0 27.1258,0.225 26.6575,0.7729 26.2132,1.6219 25.7921,2.7505 25.3928,4.1367 25.0141,5.7586 24.6548,7.5957 24.3139,9.6253 23.9898,11.8255 23.6812,14.1759 23.3874,16.6537 23.1069,19.2378 22.8382,21.9059 22.5802,24.6374 22.3321,27.4097 22.092,30.2018 21.8591,32.9911 21.6319,35.7565 21.4095,38.4765 21.1904,41.1298 20.9735,43.6941 20.7575,46.1473 20.5414,48.4687 20.3235,50.636 20.1028,52.6279 19.8782,54.4228 19.6482,55.9983 19.412,57.3339 19.168,58.4069" /&gt;
&lt;/svg&gt;</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="G010522" name="RANTES" refUnificationXrefID="ref54;ref55;" type="cso30:c:mRNA">
<csml:entitySimulationProperty>
<csml:variable variableID="m93487" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="495.0" y="767.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="26.0" height="26.0" filePath="" fileType="internal" fileFormat="svg" outlineColor="0 0 0 0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" height="60.0" viewBox="0 0 60.0 60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;&lt;linearGradient xmlns:xlink="http://www.w3.org/1999/xlink" gradientTransform="" gradientUnits="objectBoundingBox" id="id_#d28e80" spreadMethod="pad" x1="0%" x2="100%" y1="0%" y2="0%"&gt;&lt;stop offset="0%" style="stop-color:#d28e80;stop-opacity:1;"/&gt;&lt;stop offset="100%" style="stop-color:#d28e80;stop-opacity:1;"/&gt;&lt;/linearGradient&gt;&lt;linearGradient xmlns:xlink="http://www.w3.org/1999/xlink" gradientTransform="" gradientUnits="objectBoundingBox" id="id_#28163F" spreadMethod="pad" x1="0%" x2="100%" y1="0%" y2="0%"&gt;&lt;stop offset="0%" style="stop-color:#28163F;stop-opacity:1;"/&gt;&lt;stop offset="100%" style="stop-color:#28163F;stop-opacity:1;"/&gt;&lt;/linearGradient&gt;&lt;/defs&gt;&lt;polygon style="fill:url(#id_#28163F);stroke:none;" points="0,60 5.4121,55.4096 5.7389,55.06 6.0446,54.4747 6.3308,53.669 6.5988,52.6597 6.85,51.4625 7.086,50.0951 7.3084,48.5725 7.5185,46.9122 7.7176,45.1294 7.9075,43.2418 8.0893,41.2648 8.2647,39.2155 8.4352,37.1098 8.6021,34.9635 8.7669,32.7941 8.9312,30.6181 9.0962,28.4512 9.2635,26.3088 9.4348,24.2093 9.6113,22.1683 9.7943,20.2017 9.9856,18.3261 10.1866,16.5582 10.3987,14.9142 10.6231,13.4103 10.8617,12.0629 11.1155,10.8889 11.3866,9.9046 11.6759,9.1255 11.9852,8.5686 12.3157,8.2502 12.6689,8.1875 13.026,8.3869 13.3701,8.8365 13.702,9.519 10.3627,2.6373 9.9474,1.7838 9.5171,1.2214 9.0714,0.9722 8.6295,1.0511 8.2163,1.4488 7.8298,2.1448 7.4682,3.1188 7.1295,4.3492 6.812,5.8167 6.5139,7.5009 6.2331,9.3809 5.9681,11.4358 5.717,13.646 5.4777,15.9899 5.2488,18.4483 5.0285,20.9998 4.8145,23.6243 4.6051,26.3015 4.3989,29.0108 4.1935,31.7312 3.9875,34.443 3.7788,37.1246 3.5658,39.7578 3.3465,42.319 3.1191,44.7906 2.8818,47.1504 2.633,49.3783 2.3703,51.4539 2.0924,53.3568 1.7973,55.0662 1.4832,56.5624 1.1482,57.8244 0.7907,58.8315 0.4085,59.5636" /&gt;&lt;polygon style="fill:url(#id_#d28e80);stroke:none;" points="10.3627,2.6373 13.702,9.519 14.0227,10.4186 14.3318,11.5175 14.6304,12.7984 14.9186,14.2465 15.197,15.8431 15.4659,17.5716 15.726,19.4163 15.9776,21.3597 16.2211,23.3859 16.4571,25.4767 16.6861,27.6164 16.9084,29.7868 17.1245,31.9728 17.335,34.1571 17.5402,36.3224 17.7404,38.4523 17.9361,40.5304 18.1283,42.5388 18.3167,44.4618 18.5024,46.2823 18.6855,47.9831 18.8666,49.5479 19.0458,50.9596 19.2242,52.2015 19.4018,53.2575 19.579,54.1096 19.7564,54.7419 19.9346,55.1368 20.114,55.2787 20.3337,55.1534 20.5441,54.7661 18.9149,59.196 18.6519,59.6798 18.3775,59.8366 18.1532,59.6598 17.9304,59.1655 17.7086,58.3754 17.4871,57.3097 17.265,55.9903 17.0423,54.4377 16.818,52.6729 16.5919,50.717 16.3629,48.5909 16.1309,46.3156 15.8951,43.9118 15.6551,41.4012 15.4103,38.8036 15.1599,36.141 14.9033,33.4344 14.6407,30.7043 14.3704,27.9718 14.0925,25.258 13.8063,22.5839 13.5114,19.9701 13.2069,17.438 12.8924,15.009 12.5674,12.7032 12.2313,10.5418 11.883,8.5458 11.5229,6.7363 11.1497,5.1345 10.7633,3.7615" /&gt;&lt;polygon style="fill:url(#id_#d28e80);stroke:none;" points="56.1668,56.8968 50.3457,52.9266 50.4902,52.9972 50.63,53.0141 50.7648,52.982 50.8965,52.9024 51.0238,52.7798 51.1481,52.6161 51.2686,52.4147 51.3872,52.1783 51.5027,51.9101 51.6164,51.6134 51.7283,51.2895 51.8385,50.9434 51.9478,50.5768 52.0561,50.1937 52.1639,49.7964 52.2717,49.3876 52.3797,48.9706 52.4881,48.5483 52.5974,48.1236 52.7074,47.7 52.8194,47.2798 52.9331,46.8666 53.049,46.4623 53.1667,46.0709 53.2883,45.6943 53.4119,45.3375 60,47.4093 59.8448,47.8561 59.6937,48.3264 59.5458,48.8158 59.4014,49.3208 59.2591,49.8379 59.1195,50.3633 58.9816,50.8925 58.845,51.4238 58.7092,51.9512 58.5744,52.4725 58.4398,52.9833 58.305,53.4804 58.1698,53.9597 58.033,54.4173 57.8951,54.8499 57.7555,55.2542 57.6133,55.6255 57.4686,55.9613 57.3209,56.2565 57.1694,56.5081 57.0146,56.713 56.8554,56.8663 56.6913,56.9653 56.5224,57.0062 56.3475,56.984" /&gt;&lt;polygon style="fill:url(#id_#28163F);stroke:none;" points="51.4421,42.8884 46.5659,41.7203 46.7028,41.8023 46.8376,41.9525 46.9702,42.1664 47.1013,42.4378 47.231,42.761 47.3586,43.131 47.485,43.5425 47.6101,43.9887 47.7331,44.4656 47.8552,44.9675 47.9761,45.488 48.0958,46.0228 48.2148,46.5658 48.3322,47.1106 48.4494,47.6533 48.5655,48.188 48.6806,48.7082 48.795,49.2094 48.9091,49.6863 49.0228,50.1321 49.1361,50.5433 49.2485,50.9129 49.3616,51.2355 49.5412,51.6837 49.7141,52.0613 49.8808,52.3714 50.0415,52.6172 50.1962,52.8009 50.3457,52.9266 56.1668,56.8968 55.98,56.7393 55.7863,56.5095 55.5857,56.2025 55.3774,55.8145 55.1615,55.3428 54.9367,54.7828 54.796,54.3789 54.6547,53.9171 54.5133,53.4035 54.3712,52.8463 54.2288,52.2499 54.0854,51.6235 53.9414,50.9728 53.7963,50.3052 53.6505,49.6264 53.503,48.9453 53.3548,48.2666 53.2051,47.5986 53.0539,46.9476 52.9015,46.3204 52.7472,45.7241 52.5913,45.1661 52.4332,44.6518 52.2736,44.1894 52.1118,43.7852 51.9481,43.446 51.7817,43.1788 51.6129,42.9908" /&gt;&lt;polygon style="fill:url(#id_#d28e80);stroke:none;" points="46.5072,55.376 42.6178,51.7104 42.8505,51.8235 43.0946,51.7695 43.3515,51.5269 43.6224,51.0766 43.9089,50.3965 44.2118,49.4669 44.5328,48.2673 44.873,46.7766 45.2338,44.9751 45.3918,44.1922 45.5468,43.528 45.6996,42.976 45.85,42.5312 45.9977,42.1879 46.143,41.9407 46.2862,41.784 46.4271,41.7127 46.5659,41.7203 51.4421,42.8884 51.2686,42.8787 51.0923,42.968 50.9139,43.1639 50.7321,43.473 50.5475,43.9021 50.3595,44.4587 50.1684,45.1481 49.9745,45.9788 49.7769,46.9562 49.326,49.2087 48.9008,51.0721 48.4993,52.5718 48.1208,53.7337 47.7629,54.5837 47.4244,55.1469 47.103,55.4494 46.7979,55.5179" /&gt;&lt;polygon style="fill:url(#id_#28163F);stroke:none;" points="42.7693,45.6178 39.6278,43.9039 39.843,44.061 40.0506,44.359 40.2515,44.7778 40.4475,45.2963 40.6388,45.8933 40.828,46.5502 41.015,47.2449 41.2027,47.9575 41.3909,48.6667 41.5816,49.3527 41.7764,49.9943 41.9763,50.5717 42.182,51.0638 42.3954,51.4504 42.6178,51.7104 46.5072,55.376 46.2289,55.0506 45.9622,54.5678 45.7048,53.9528 45.4555,53.2308 45.2122,52.4285 44.9734,51.5712 44.7381,50.6848 44.5038,49.7943 44.2696,48.9259 44.0336,48.1049 43.7941,47.358 43.5493,46.7098 43.2981,46.1868 43.0389,45.814" /&gt;&lt;polygon style="fill:url(#id_#d28e80);stroke:none;" points="37.2968,58.9458 35.2497,54.5661 35.4034,54.8741 35.5619,55.0825 35.7257,55.1839 35.8945,55.1721 36.0692,55.0399 36.2492,54.781 36.4354,54.3885 36.6279,53.8562 36.8266,53.1772 37.0321,52.3448 37.2442,51.3518 37.4635,50.1923 37.789,48.4808 38.0959,47.0746 38.3862,45.9539 38.6604,45.0973 38.9205,44.4843 39.1677,44.0949 39.403,43.9084 39.6278,43.9039 42.7693,45.6178 42.4887,45.6233 42.1944,45.857 41.8857,46.3439 41.5604,47.1099 41.2175,48.1807 40.8548,49.5814 40.4708,51.339 40.0643,53.4783 39.7901,54.9278 39.5249,56.1689 39.2682,57.2097 39.0199,58.059 38.7793,58.7239 38.5464,59.214 38.3212,59.5379 38.103,59.7034 37.8918,59.7179 37.6872,59.5912 37.4889,59.331" /&gt;&lt;polygon style="fill:url(#id_#28163F);stroke:none;" points="18.9149,59.196 20.5441,54.7661 20.7465,54.1348 20.9416,53.2765 21.1309,52.2081 21.3148,50.9479 21.4944,49.5115 21.6709,47.9184 21.845,46.1844 22.0182,44.3275 22.1908,42.3647 22.3646,40.3133 22.5398,38.1907 22.7176,36.0147 22.8994,33.8023 23.0856,31.5706 23.2776,29.3372 23.4763,27.1193 23.6825,24.9344 23.8976,22.7999 24.122,20.7326 24.3571,18.7501 24.604,16.87 24.8633,15.1097 25.136,13.4858 25.4234,12.0162 25.7263,10.7186 26.0457,9.6097 26.3825,8.7074 26.7381,8.028 27.1129,7.5891 27.5082,7.4095 27.811,7.4389 28.1009,7.5919 28.3782,7.8622 28.6434,8.2436 28.897,8.7289 29.1391,9.3117 29.3705,9.9866 29.5914,10.746 29.8025,11.5843 30.0038,12.4942 30.1959,13.4695 30.3792,14.5047 30.554,15.5915 30.7211,16.7254 30.8809,17.8987 31.0334,19.1055 31.1792,20.3387 31.3186,21.5923 31.4523,22.8601 31.5807,24.1355 31.7039,25.4116 31.8227,26.6825 31.9373,27.9413 32.0481,29.1818 32.1555,30.3977 32.26,31.5821 32.3622,32.7287 32.4623,33.8314 32.5607,34.8832 32.6577,35.878 32.7541,36.809 32.8501,37.6701 32.9535,38.5773 33.0575,39.5183 33.162,40.4857 33.2674,41.4735 33.3736,42.4744 33.4814,43.4823 33.5907,44.4902 33.7016,45.4922 33.8144,46.48 33.9295,47.4484 34.0471,48.3901 34.1672,49.2987 34.2902,50.1671 34.4164,50.9887 34.5457,51.7574 34.6785,52.4656 34.8151,53.1072 34.9556,53.6756 35.1004,54.1643 35.2497,54.5661 37.2968,58.9458 37.1103,58.4435 36.9294,57.833 36.7537,57.1225 36.583,56.3202 36.4168,55.4348 36.2552,54.474 36.0976,53.4468 35.9439,52.3617 35.7939,51.2258 35.6469,50.049 35.5031,48.8383 35.3619,47.6034 35.2232,46.3512 35.0866,45.0914 34.952,43.8312 34.819,42.58 34.6873,41.3454 34.5565,40.1361 34.4267,38.9601 34.2976,37.8262 34.1775,36.7495 34.0572,35.5855 33.9356,34.3416 33.8127,33.0267 33.6876,31.6489 33.5602,30.2153 33.4294,28.735 33.295,27.2152 33.1565,25.665 33.0132,24.0912 32.8648,22.5026 32.7107,20.9077 32.5502,19.3136 32.3831,17.7291 32.2088,16.1615 32.0266,14.6203 31.836,13.1113 31.6365,11.6452 31.4275,10.2275 31.2089,8.869 30.9797,7.5753 30.7395,6.3559 30.4879,5.2186 30.2242,4.1706 29.9481,3.2212 29.6587,2.3781 29.356,1.6492 29.0392,1.0425 28.7077,0.5659 28.3609,0.2281 27.9986,0.0363 27.6202,0 27.1258,0.225 26.6575,0.7729 26.2132,1.6219 25.7921,2.7505 25.3928,4.1367 25.0141,5.7586 24.6548,7.5957 24.3139,9.6253 23.9898,11.8255 23.6812,14.1759 23.3874,16.6537 23.1069,19.2378 22.8382,21.9059 22.5802,24.6374 22.3321,27.4097 22.092,30.2018 21.8591,32.9911 21.6319,35.7565 21.4095,38.4765 21.1904,41.1298 20.9735,43.6941 20.7575,46.1473 20.5414,48.4687 20.3235,50.636 20.1028,52.6279 19.8782,54.4228 19.6482,55.9983 19.412,57.3339 19.168,58.4069" /&gt;
&lt;/svg&gt;</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e32" name="TLR9:CpG dinucleotides:MyD88" type="cso30:c:Complex">
<csml:entitySimulationProperty>
<csml:variable variableID="m33" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="757.5" y="533.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="21.11726922371077" height="29.465957056340606" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="30" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="MO000007685" name="IRF-1" refUnificationXrefID="ref56;ref57;" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable variableID="m970" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="808.0" y="684.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="24.0" height="24.0" filePath="" fileType="internal" fileFormat="svg" outlineColor="0 0 0 0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" viewBox="0 0 60.0 60.0" height="60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;
&lt;radialGradient id="MO_6df154" gradientUnits="objectBoundingBox" spreadMethod="pad" xlink:show="other" xlink:type="simple" r="50%" cx="50%" fx="50%" cy="50%" fy="50%" xlink:actuate="onLoad"&gt;
&lt;stop style="stop-color:white;stop-opacity:1;" offset="0%"/&gt;
&lt;stop style="stop-color:#6df154;stop-opacity:1;" offset="0%"/&gt;
&lt;/radialGradient&gt;
&lt;/defs&gt;
&lt;path d="M 60 48.5413 c -5.4791 -8.878 6.0417 -4.3573 -9.8171 -2.9348 l -4.5651 -27.6151 c -1.9754 -5.4859 12.2339 -9.9822 14.3816 -6.5322 c -10.571 2.2124 -2.4899 -6.8115 -5.9681 7.9727 l -29.0256 -4.4044 c -6.096 0.0919 -6.2013 -14.1503 -2.0879 -15.0274 c -1.0542 10.2454 -7.5808 0.1474 6.1282 7.8622 l -13.374 24.8929 c -1.7923 5.5423 -16.0665 1.2366 -15.6721 -2.7553 c 9.9194 4.1194 -2.1948 6.9024 9.7557 -3.1134 l 20.7599 19.7894 c 4.9886 3.3337 -3.7283 14.915 -7.5982 13.3243 c 7.1844 -7.6993 6.2238 4.1184 -0.0987 -9.7867 l 26.2042 -12.6627 c 4.875 -3.4821 13.7627 7.9809 10.9766 10.9902 z" style="fill:url(#MO_6df154);stroke:none;"/&gt;
&lt;/svg&gt;
</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e33" name="IRF-1{active}" refUnificationXrefID="ref58;ref59;" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable variableID="m34" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="792.0" y="756.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="24.0" height="24.0" filePath="" fileType="internal" fileFormat="svg" outlineColor="0 0 0 0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" viewBox="0 0 60.0 60.0" height="60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;
&lt;radialGradient id="MO_6df154" gradientUnits="objectBoundingBox" spreadMethod="pad" xlink:show="other" xlink:type="simple" r="50%" cx="50%" fx="50%" cy="50%" fy="50%" xlink:actuate="onLoad"&gt;
&lt;stop style="stop-color:white;stop-opacity:1;" offset="0%"/&gt;
&lt;stop style="stop-color:#6df154;stop-opacity:1;" offset="0%"/&gt;
&lt;/radialGradient&gt;
&lt;/defs&gt;
&lt;path d="M 60 48.5413 c -5.4791 -8.878 6.0417 -4.3573 -9.8171 -2.9348 l -4.5651 -27.6151 c -1.9754 -5.4859 12.2339 -9.9822 14.3816 -6.5322 c -10.571 2.2124 -2.4899 -6.8115 -5.9681 7.9727 l -29.0256 -4.4044 c -6.096 0.0919 -6.2013 -14.1503 -2.0879 -15.0274 c -1.0542 10.2454 -7.5808 0.1474 6.1282 7.8622 l -13.374 24.8929 c -1.7923 5.5423 -16.0665 1.2366 -15.6721 -2.7553 c 9.9194 4.1194 -2.1948 6.9024 9.7557 -3.1134 l 20.7599 19.7894 c 4.9886 3.3337 -3.7283 14.915 -7.5982 13.3243 c 7.1844 -7.6993 6.2238 4.1184 -0.0987 -9.7867 l 26.2042 -12.6627 c 4.875 -3.4821 13.7627 7.9809 10.9766 10.9902 z" style="fill:url(#MO_6df154);stroke:none;"/&gt;
&lt;/svg&gt;
</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="G010514" name="iNOS" refUnificationXrefID="ref60;ref61;" type="cso30:c:mRNA">
<csml:entitySimulationProperty>
<csml:variable variableID="m93479" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="600.0" y="984.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="24.0" height="24.0" filePath="" fileType="internal" fileFormat="svg" outlineColor="0 0 0 0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" height="60.0" viewBox="0 0 60.0 60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;&lt;linearGradient xmlns:xlink="http://www.w3.org/1999/xlink" gradientTransform="" gradientUnits="objectBoundingBox" id="id_#2ff5d8" spreadMethod="pad" x1="0%" x2="100%" y1="0%" y2="0%"&gt;&lt;stop offset="0%" style="stop-color:#2ff5d8;stop-opacity:1;"/&gt;&lt;stop offset="100%" style="stop-color:#2ff5d8;stop-opacity:1;"/&gt;&lt;/linearGradient&gt;&lt;linearGradient xmlns:xlink="http://www.w3.org/1999/xlink" gradientTransform="" gradientUnits="objectBoundingBox" id="id_#28163F" spreadMethod="pad" x1="0%" x2="100%" y1="0%" y2="0%"&gt;&lt;stop offset="0%" style="stop-color:#28163F;stop-opacity:1;"/&gt;&lt;stop offset="100%" style="stop-color:#28163F;stop-opacity:1;"/&gt;&lt;/linearGradient&gt;&lt;/defs&gt;&lt;polygon style="fill:url(#id_#28163F);stroke:none;" points="0,60 5.4121,55.4096 5.7389,55.06 6.0446,54.4747 6.3308,53.669 6.5988,52.6597 6.85,51.4625 7.086,50.0951 7.3084,48.5725 7.5185,46.9122 7.7176,45.1294 7.9075,43.2418 8.0893,41.2648 8.2647,39.2155 8.4352,37.1098 8.6021,34.9635 8.7669,32.7941 8.9312,30.6181 9.0962,28.4512 9.2635,26.3088 9.4348,24.2093 9.6113,22.1683 9.7943,20.2017 9.9856,18.3261 10.1866,16.5582 10.3987,14.9142 10.6231,13.4103 10.8617,12.0629 11.1155,10.8889 11.3866,9.9046 11.6759,9.1255 11.9852,8.5686 12.3157,8.2502 12.6689,8.1875 13.026,8.3869 13.3701,8.8365 13.702,9.519 10.3627,2.6373 9.9474,1.7838 9.5171,1.2214 9.0714,0.9722 8.6295,1.0511 8.2163,1.4488 7.8298,2.1448 7.4682,3.1188 7.1295,4.3492 6.812,5.8167 6.5139,7.5009 6.2331,9.3809 5.9681,11.4358 5.717,13.646 5.4777,15.9899 5.2488,18.4483 5.0285,20.9998 4.8145,23.6243 4.6051,26.3015 4.3989,29.0108 4.1935,31.7312 3.9875,34.443 3.7788,37.1246 3.5658,39.7578 3.3465,42.319 3.1191,44.7906 2.8818,47.1504 2.633,49.3783 2.3703,51.4539 2.0924,53.3568 1.7973,55.0662 1.4832,56.5624 1.1482,57.8244 0.7907,58.8315 0.4085,59.5636" /&gt;&lt;polygon style="fill:url(#id_#2ff5d8);stroke:none;" points="10.3627,2.6373 13.702,9.519 14.0227,10.4186 14.3318,11.5175 14.6304,12.7984 14.9186,14.2465 15.197,15.8431 15.4659,17.5716 15.726,19.4163 15.9776,21.3597 16.2211,23.3859 16.4571,25.4767 16.6861,27.6164 16.9084,29.7868 17.1245,31.9728 17.335,34.1571 17.5402,36.3224 17.7404,38.4523 17.9361,40.5304 18.1283,42.5388 18.3167,44.4618 18.5024,46.2823 18.6855,47.9831 18.8666,49.5479 19.0458,50.9596 19.2242,52.2015 19.4018,53.2575 19.579,54.1096 19.7564,54.7419 19.9346,55.1368 20.114,55.2787 20.3337,55.1534 20.5441,54.7661 18.9149,59.196 18.6519,59.6798 18.3775,59.8366 18.1532,59.6598 17.9304,59.1655 17.7086,58.3754 17.4871,57.3097 17.265,55.9903 17.0423,54.4377 16.818,52.6729 16.5919,50.717 16.3629,48.5909 16.1309,46.3156 15.8951,43.9118 15.6551,41.4012 15.4103,38.8036 15.1599,36.141 14.9033,33.4344 14.6407,30.7043 14.3704,27.9718 14.0925,25.258 13.8063,22.5839 13.5114,19.9701 13.2069,17.438 12.8924,15.009 12.5674,12.7032 12.2313,10.5418 11.883,8.5458 11.5229,6.7363 11.1497,5.1345 10.7633,3.7615" /&gt;&lt;polygon style="fill:url(#id_#2ff5d8);stroke:none;" points="56.1668,56.8968 50.3457,52.9266 50.4902,52.9972 50.63,53.0141 50.7648,52.982 50.8965,52.9024 51.0238,52.7798 51.1481,52.6161 51.2686,52.4147 51.3872,52.1783 51.5027,51.9101 51.6164,51.6134 51.7283,51.2895 51.8385,50.9434 51.9478,50.5768 52.0561,50.1937 52.1639,49.7964 52.2717,49.3876 52.3797,48.9706 52.4881,48.5483 52.5974,48.1236 52.7074,47.7 52.8194,47.2798 52.9331,46.8666 53.049,46.4623 53.1667,46.0709 53.2883,45.6943 53.4119,45.3375 60,47.4093 59.8448,47.8561 59.6937,48.3264 59.5458,48.8158 59.4014,49.3208 59.2591,49.8379 59.1195,50.3633 58.9816,50.8925 58.845,51.4238 58.7092,51.9512 58.5744,52.4725 58.4398,52.9833 58.305,53.4804 58.1698,53.9597 58.033,54.4173 57.8951,54.8499 57.7555,55.2542 57.6133,55.6255 57.4686,55.9613 57.3209,56.2565 57.1694,56.5081 57.0146,56.713 56.8554,56.8663 56.6913,56.9653 56.5224,57.0062 56.3475,56.984" /&gt;&lt;polygon style="fill:url(#id_#28163F);stroke:none;" points="51.4421,42.8884 46.5659,41.7203 46.7028,41.8023 46.8376,41.9525 46.9702,42.1664 47.1013,42.4378 47.231,42.761 47.3586,43.131 47.485,43.5425 47.6101,43.9887 47.7331,44.4656 47.8552,44.9675 47.9761,45.488 48.0958,46.0228 48.2148,46.5658 48.3322,47.1106 48.4494,47.6533 48.5655,48.188 48.6806,48.7082 48.795,49.2094 48.9091,49.6863 49.0228,50.1321 49.1361,50.5433 49.2485,50.9129 49.3616,51.2355 49.5412,51.6837 49.7141,52.0613 49.8808,52.3714 50.0415,52.6172 50.1962,52.8009 50.3457,52.9266 56.1668,56.8968 55.98,56.7393 55.7863,56.5095 55.5857,56.2025 55.3774,55.8145 55.1615,55.3428 54.9367,54.7828 54.796,54.3789 54.6547,53.9171 54.5133,53.4035 54.3712,52.8463 54.2288,52.2499 54.0854,51.6235 53.9414,50.9728 53.7963,50.3052 53.6505,49.6264 53.503,48.9453 53.3548,48.2666 53.2051,47.5986 53.0539,46.9476 52.9015,46.3204 52.7472,45.7241 52.5913,45.1661 52.4332,44.6518 52.2736,44.1894 52.1118,43.7852 51.9481,43.446 51.7817,43.1788 51.6129,42.9908" /&gt;&lt;polygon style="fill:url(#id_#2ff5d8);stroke:none;" points="46.5072,55.376 42.6178,51.7104 42.8505,51.8235 43.0946,51.7695 43.3515,51.5269 43.6224,51.0766 43.9089,50.3965 44.2118,49.4669 44.5328,48.2673 44.873,46.7766 45.2338,44.9751 45.3918,44.1922 45.5468,43.528 45.6996,42.976 45.85,42.5312 45.9977,42.1879 46.143,41.9407 46.2862,41.784 46.4271,41.7127 46.5659,41.7203 51.4421,42.8884 51.2686,42.8787 51.0923,42.968 50.9139,43.1639 50.7321,43.473 50.5475,43.9021 50.3595,44.4587 50.1684,45.1481 49.9745,45.9788 49.7769,46.9562 49.326,49.2087 48.9008,51.0721 48.4993,52.5718 48.1208,53.7337 47.7629,54.5837 47.4244,55.1469 47.103,55.4494 46.7979,55.5179" /&gt;&lt;polygon style="fill:url(#id_#28163F);stroke:none;" points="42.7693,45.6178 39.6278,43.9039 39.843,44.061 40.0506,44.359 40.2515,44.7778 40.4475,45.2963 40.6388,45.8933 40.828,46.5502 41.015,47.2449 41.2027,47.9575 41.3909,48.6667 41.5816,49.3527 41.7764,49.9943 41.9763,50.5717 42.182,51.0638 42.3954,51.4504 42.6178,51.7104 46.5072,55.376 46.2289,55.0506 45.9622,54.5678 45.7048,53.9528 45.4555,53.2308 45.2122,52.4285 44.9734,51.5712 44.7381,50.6848 44.5038,49.7943 44.2696,48.9259 44.0336,48.1049 43.7941,47.358 43.5493,46.7098 43.2981,46.1868 43.0389,45.814" /&gt;&lt;polygon style="fill:url(#id_#2ff5d8);stroke:none;" points="37.2968,58.9458 35.2497,54.5661 35.4034,54.8741 35.5619,55.0825 35.7257,55.1839 35.8945,55.1721 36.0692,55.0399 36.2492,54.781 36.4354,54.3885 36.6279,53.8562 36.8266,53.1772 37.0321,52.3448 37.2442,51.3518 37.4635,50.1923 37.789,48.4808 38.0959,47.0746 38.3862,45.9539 38.6604,45.0973 38.9205,44.4843 39.1677,44.0949 39.403,43.9084 39.6278,43.9039 42.7693,45.6178 42.4887,45.6233 42.1944,45.857 41.8857,46.3439 41.5604,47.1099 41.2175,48.1807 40.8548,49.5814 40.4708,51.339 40.0643,53.4783 39.7901,54.9278 39.5249,56.1689 39.2682,57.2097 39.0199,58.059 38.7793,58.7239 38.5464,59.214 38.3212,59.5379 38.103,59.7034 37.8918,59.7179 37.6872,59.5912 37.4889,59.331" /&gt;&lt;polygon style="fill:url(#id_#28163F);stroke:none;" points="18.9149,59.196 20.5441,54.7661 20.7465,54.1348 20.9416,53.2765 21.1309,52.2081 21.3148,50.9479 21.4944,49.5115 21.6709,47.9184 21.845,46.1844 22.0182,44.3275 22.1908,42.3647 22.3646,40.3133 22.5398,38.1907 22.7176,36.0147 22.8994,33.8023 23.0856,31.5706 23.2776,29.3372 23.4763,27.1193 23.6825,24.9344 23.8976,22.7999 24.122,20.7326 24.3571,18.7501 24.604,16.87 24.8633,15.1097 25.136,13.4858 25.4234,12.0162 25.7263,10.7186 26.0457,9.6097 26.3825,8.7074 26.7381,8.028 27.1129,7.5891 27.5082,7.4095 27.811,7.4389 28.1009,7.5919 28.3782,7.8622 28.6434,8.2436 28.897,8.7289 29.1391,9.3117 29.3705,9.9866 29.5914,10.746 29.8025,11.5843 30.0038,12.4942 30.1959,13.4695 30.3792,14.5047 30.554,15.5915 30.7211,16.7254 30.8809,17.8987 31.0334,19.1055 31.1792,20.3387 31.3186,21.5923 31.4523,22.8601 31.5807,24.1355 31.7039,25.4116 31.8227,26.6825 31.9373,27.9413 32.0481,29.1818 32.1555,30.3977 32.26,31.5821 32.3622,32.7287 32.4623,33.8314 32.5607,34.8832 32.6577,35.878 32.7541,36.809 32.8501,37.6701 32.9535,38.5773 33.0575,39.5183 33.162,40.4857 33.2674,41.4735 33.3736,42.4744 33.4814,43.4823 33.5907,44.4902 33.7016,45.4922 33.8144,46.48 33.9295,47.4484 34.0471,48.3901 34.1672,49.2987 34.2902,50.1671 34.4164,50.9887 34.5457,51.7574 34.6785,52.4656 34.8151,53.1072 34.9556,53.6756 35.1004,54.1643 35.2497,54.5661 37.2968,58.9458 37.1103,58.4435 36.9294,57.833 36.7537,57.1225 36.583,56.3202 36.4168,55.4348 36.2552,54.474 36.0976,53.4468 35.9439,52.3617 35.7939,51.2258 35.6469,50.049 35.5031,48.8383 35.3619,47.6034 35.2232,46.3512 35.0866,45.0914 34.952,43.8312 34.819,42.58 34.6873,41.3454 34.5565,40.1361 34.4267,38.9601 34.2976,37.8262 34.1775,36.7495 34.0572,35.5855 33.9356,34.3416 33.8127,33.0267 33.6876,31.6489 33.5602,30.2153 33.4294,28.735 33.295,27.2152 33.1565,25.665 33.0132,24.0912 32.8648,22.5026 32.7107,20.9077 32.5502,19.3136 32.3831,17.7291 32.2088,16.1615 32.0266,14.6203 31.836,13.1113 31.6365,11.6452 31.4275,10.2275 31.2089,8.869 30.9797,7.5753 30.7395,6.3559 30.4879,5.2186 30.2242,4.1706 29.9481,3.2212 29.6587,2.3781 29.356,1.6492 29.0392,1.0425 28.7077,0.5659 28.3609,0.2281 27.9986,0.0363 27.6202,0 27.1258,0.225 26.6575,0.7729 26.2132,1.6219 25.7921,2.7505 25.3928,4.1367 25.0141,5.7586 24.6548,7.5957 24.3139,9.6253 23.9898,11.8255 23.6812,14.1759 23.3874,16.6537 23.1069,19.2378 22.8382,21.9059 22.5802,24.6374 22.3321,27.4097 22.092,30.2018 21.8591,32.9911 21.6319,35.7565 21.4095,38.4765 21.1904,41.1298 20.9735,43.6941 20.7575,46.1473 20.5414,48.4687 20.3235,50.636 20.1028,52.6279 19.8782,54.4228 19.6482,55.9983 19.412,57.3339 19.168,58.4069" /&gt;
&lt;/svg&gt;</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Nucleoplasm">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e34" name="TLR7:ssRNA:MyD88" type="cso30:c:Complex">
<csml:entitySimulationProperty>
<csml:variable variableID="m35" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="682.5" y="479.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="18.552578454762344" height="25.887318774086992" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="30" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="MO000066987" name="DDX58" refUnificationXrefID="ref62;" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable variableID="m41844" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="806.0" y="846.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="20.0" height="20.0" filePath="" fileType="internal" fileFormat="svg" outlineColor="0 0 0 0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" height="60.0" viewBox="0 0 60.0 60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;
&lt;radialGradient id="MO_75175a" gradientUnits="objectBoundingBox" spreadMethod="pad" xlink:show="other" xlink:type="simple" r="50%" cx="50%" fx="50%" fy="50%" cy="50%" xlink:actuate="onLoad"&gt;
&lt;stop offset="0%" style="stop-color:white;stop-opacity:1;"/&gt;
&lt;stop offset="100%" style="stop-color:#75175a;stop-opacity:1;"/&gt;
&lt;/radialGradient&gt;
&lt;/defs&gt;
&lt;path style="fill:url(#MO_75175a);stroke:none;" d="M 55.1649 47.5686 c 0.5601 -7.2179 4.714 10.4493 -1.2168 -14.4358 c 2.6176 -7.4525 9.2483 -0.5606 -1.731 -25.2694 c 2.8438 -1.6074 6.452 -2.3695 7.7829 16.8886 c 2.2607 -1.648 3.0198 0.1667 -4.8357 -13.094 c -6.6798 -2.7638 11.3773 -1.2622 -14.0813 -3.302 c -6.2663 -4.7972 2.3258 -8.9846 -24.525 -6.1598 c -0.6471 -3.2063 -0.2561 -6.8791 18.4384 -2.1963 c -0.8663 -2.6634 1.0914 -2.8258 -13.9255 0.5606 c -4.6884 5.5095 2.3178 -11.2295 -7.4858 12.3956 c -6.4904 4.4877 -7.8112 -4.9922 -13.4267 21.4624 c -3.2439 -0.3741 -6.6099 -1.8821 3.6125 -18.246 c -2.7963 0.0021 -2.3455 -1.9131 -3.7709 13.4408 c 3.7821 6.1695 -9.9444 -5.6778 9.4547 10.9623 c 2.2549 7.5706 -7.1529 5.8991 16.2273 19.4243 c -1.3576 2.9749 -3.8296 5.7158 -16.206 -9.0802 c -0.862 2.6644 -2.5413 1.6432 11.5949 7.7464 c 7.026 -1.6967 -8.4636 7.7202 13.3291 -5.6201 c 7.8837 0.1913 3.39 8.6378 23.4555 -9.4575 c 2.4048 2.2129 4.243 5.4144 -13.6284 12.6339 c 2.2634 1.6448 0.7751 2.929 10.9372 -8.6533 z" /&gt;
&lt;/svg&gt;</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="MO000103999" name="IFIH1" refUnificationXrefID="ref63;" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable variableID="m76904" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="911.0" y="975.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="18.0" height="18.0" filePath="" fileType="internal" fileFormat="svg" outlineColor="0 0 0 0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" height="60.0" viewBox="0 0 60.0 60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;
&lt;radialGradient id="MO_1ec8f1" gradientUnits="objectBoundingBox" spreadMethod="pad" xlink:show="other" xlink:type="simple" r="50%" cx="50%" fx="50%" fy="50%" cy="50%" xlink:actuate="onLoad"&gt;
&lt;stop offset="0%" style="stop-color:white;stop-opacity:1;"/&gt;
&lt;stop offset="100%" style="stop-color:#1ec8f1;stop-opacity:1;"/&gt;
&lt;/radialGradient&gt;
&lt;/defs&gt;
&lt;path style="fill:url(#MO_1ec8f1);stroke:none;" d="M 60 48.5418 c -2.9644 -1.7553 -2.5903 -6.4943 -2.5531 -2.2866 c 4.9418 -1.2857 7.2631 -6.8443 -4.1717 -7.7833 l 6.3504 -2.0842 l 0.3744 -24.9285 c -2.6713 2.1389 -7.2945 0.3361 -3.0755 1.6028 c 0.2413 -4.8673 -4.5994 -8.6848 -9.0725 1.3684 l -0.1216 -6.3883 l -24.8123 -8.0421 c 1.3134 3.0773 -1.918 6.7021 0.6523 3.2769 c -4.7925 -1.7224 -10.1058 1.4769 -1.4353 8.6289 l -6.4257 -1.8641 l -15.7093 19.9582 c 3.4829 -0.2371 6.1091 3.8057 3.4785 0.4225 c -3.2035 3.8027 -1.6462 9.5975 8.1852 3.9646 l -3.8497 5.2361 l 15.1034 20.3768 c 0.8393 -3.2237 5.6937 -4.35 1.4976 -3.0159 c 2.8126 4.0727 9.0884 4.4548 6.494 -6.1787 l 4.0466 5.1002 l 25.0438 -7.3647 z" /&gt;
&lt;/svg&gt;</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e35" name="ssRNA" type="cso30:c:Dna">
<csml:entitySimulationProperty>
<csml:variable variableID="m36" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="862.0" y="830.5"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="60.0" height="19.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="45" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Extracellular">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e36" name="DDX58:ssRNA" type="cso30:c:Complex">
<csml:entitySimulationProperty>
<csml:variable variableID="m37" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="781.5" y="1007.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="21.54824195967339" height="26.385602399600067" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="12" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e37" name="IFIH1:ssRNA" type="cso30:c:Complex">
<csml:entitySimulationProperty>
<csml:variable variableID="m38" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="889.5" y="1035.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="21.54824195967339" height="26.385602399600067" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="12" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="MO000094908" name="MAVS" refUnificationXrefID="ref64;" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable variableID="m68199" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="718.0" y="1074.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="20.0" height="20.0" filePath="" fileType="internal" fileFormat="svg" outlineColor="0 0 0 0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" viewBox="0 0 60.0 60.0" height="60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;
&lt;radialGradient id="MO_27af0a" gradientUnits="objectBoundingBox" spreadMethod="pad" xlink:show="other" xlink:type="simple" r="50%" cx="50%" fx="50%" cy="50%" fy="50%" xlink:actuate="onLoad"&gt;
&lt;stop style="stop-color:white;stop-opacity:1;" offset="0%"/&gt;
&lt;stop style="stop-color:#27af0a;stop-opacity:1;" offset="4%"/&gt;
&lt;/radialGradient&gt;
&lt;/defs&gt;
&lt;path d="M 59.9992 48.5408 c -4.8875 -0.5772 -6.444 -4.509 -4.4684 -8.7121 l -5.1097 -15.2681 c -2.3994 -10.3754 10.5012 -2.7373 9.578 -13.1018 c -2.0877 4.2424 -6.5002 4.4351 -10.0928 1.3497 l -16.847 -0.0964 c -11.1166 -1.0359 0.5075 -10.3444 -10.1418 -12.7122 c 3.5976 3.1992 2.4265 7.2499 -1.7691 9.5461 l -5.3024 15.2088 c -4.4714 9.7352 -10.1876 -3.6557 -15.8461 5.2451 c 4.3108 -2.2652 8.0001 0.0455 8.9994 4.5501 l 13.5703 9.4959 c 8.3535 7.0524 -6.8039 8.085 0.3484 15.954 c -0.9331 -4.5992 2.5176 -7.2219 7.3313 -6.7338 l 13.6892 -9.3399 c 9.6339 -5.3764 5.9824 8.6524 16.0614 4.6148 z" style="fill:url(#MO_27af0a);stroke:none;"/&gt;
&lt;/svg&gt;
</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e38" name="DDX58:ssRNA:MAVS" type="cso30:c:Complex">
<csml:entitySimulationProperty>
<csml:variable variableID="m39" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="681.5" y="1166.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="20.16241512204074" height="28.133602495870804" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="30" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e39" name="IFIH1:ssRNA:MAVS" type="cso30:c:Complex">
<csml:entitySimulationProperty>
<csml:variable variableID="m40" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="889.5" y="1106.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="20.16241512204074" height="28.133602495870804" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="30" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e40" name="Serine protease" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable variableID="m41" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="921.5" y="697.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="13.8945461863554" height="22.531696518414158" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="35" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e41" name="protein remnants" type="cso30:c:EntityBiological">
<csml:entitySimulationProperty>
<csml:variable variableID="m42" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="849.0" y="722.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="21.711659965537052" height="20.987937966685816" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="70" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e42" name="HA" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable variableID="m43" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="317.0" y="783.5"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="22.88" height="17.160000000000004" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="34" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e43" name="CD150" type="cso30:c:mRNA">
<csml:entitySimulationProperty>
<csml:variable variableID="m44" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="367.0" y="1009.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="42.35294117647059" height="22.588235294117645" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="37" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Nucleoplasm">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e44" name="Cd150" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable variableID="m45" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="168.5" y="970.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="23.532513181019333" height="36.20386643233743" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="13" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="MO000000212" name="TRAF6" refUnificationXrefID="ref65;ref66;ref67;ref68;ref69;ref70;" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable variableID="m183" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="242.0" y="450.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="20.0" height="20.0" filePath="" fileType="internal" fileFormat="svg" outlineColor="0 0 0 0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" height="60.0" viewBox="0 0 60.0 60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;
&lt;radialGradient id="MO_8b1f27" gradientUnits="objectBoundingBox" spreadMethod="pad" xlink:show="other" xlink:type="simple" r="50%" cx="50%" fx="50%" fy="50%" cy="50%" xlink:actuate="onLoad"&gt;
&lt;stop offset="0%" style="stop-color:white;stop-opacity:1;"/&gt;
&lt;stop offset="100%" style="stop-color:#8b1f27;stop-opacity:1;"/&gt;
&lt;/radialGradient&gt;
&lt;/defs&gt;
&lt;path style="fill:url(#MO_8b1f27);stroke:none;" d="M 52.8059 47.4706 c -7.7431 -3.717 11.6089 -12.322 7.1941 -19.4363 l -0.9501 -11.2137 l -6.244 -1.3273 c -5.8784 6.3193 -7.9683 -15.0039 -16.0049 -12.9444 l -10.8101 -2.5489 l -3.1742 5.6121 c 4.11 7.6223 -16.5332 3.0487 -17.0856 11.4363 l -5.7311 9.6382 l 4.2819 4.7956 c 8.4188 -1.6086 -2.2498 16.888 5.4452 20.0122 l 7.2681 8.5056 l 5.8205 -2.6483 c 1.0928 -8.6166 15.143 7.3886 20.4506 0.9322 l 10.2227 -4.3818 l -0.6848 -6.4321 z" /&gt;
&lt;/svg&gt;</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e45" name="A52" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable variableID="m46" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="328.0" y="364.5"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="24.379150734554226" height="15.033809619641776" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="11" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="MO000016566" name="IRAK-2" refUnificationXrefID="ref71;ref72;ref73;" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable variableID="m1569" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="303.0" y="323.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="18.0" height="18.0" filePath="" fileType="internal" fileFormat="svg" outlineColor="0 0 0 0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" height="60.0" viewBox="0 0 60.0 60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;
&lt;radialGradient id="MO_6d6841" gradientUnits="objectBoundingBox" spreadMethod="pad" xlink:show="other" xlink:type="simple" r="50%" cx="50%" fx="50%" fy="50%" cy="50%" xlink:actuate="onLoad"&gt;
&lt;stop offset="0%" style="stop-color:white;stop-opacity:1;"/&gt;
&lt;stop offset="100%" style="stop-color:#6d6841;stop-opacity:1;"/&gt;
&lt;/radialGradient&gt;
&lt;/defs&gt;
&lt;path style="fill:url(#MO_6d6841);stroke:none;" d="M 53.1117 45.8329 c -1.171 -4.7103 0.7422 -4.435 6.8883 -9.5688 l -0.7383 -5.3439 l -1.9522 -9.4672 c -3.3869 -5.177 0.4165 -2.7857 -2.6392 -6.1659 l -1.5587 -3.7825 c -4.8658 -0.348 -4.0114 -2.0724 -7.0211 -9.4728 l -5.338 -0.953 l -9.6559 -1.0788 c -5.9968 1.6041 -2.5349 -1.2548 -6.7114 0.5909 l -4.0985 0.3055 c -1.8364 4.4953 -3.2214 3.1542 -11.2276 3.7144 l -2.5607 4.7549 l -4.0154 8.8004 c -0.3192 6.1685 -1.9833 2.0101 -1.5088 6.5312 l -0.9744 3.9714 c 3.731 3.1263 2.0205 4.022 0.0822 11.7684 l 3.7554 3.8917 l 7.1741 6.5178 c 5.7995 2.2082 1.3091 2.4973 5.7788 3.4456 l 3.4963 2.1488 c 4.1421 -2.5631 4.4699 -0.6685 11.2784 3.559 l 4.8816 -2.3497 l 8.4493 -4.7722 c 3.9035 -4.8036 2.7924 -0.4669 5.0805 -4.4018 l 3.135 -2.6432 z" /&gt;
&lt;/svg&gt;</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e46" name="A52:TRAF6:IRAK-2" type="cso30:c:Complex">
<csml:entitySimulationProperty>
<csml:variable variableID="m47" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="314.5" y="430.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="19.452193062947334" height="27.14259497155442" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="30" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Extracellular">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="MO000019394" name="TLR4" refUnificationXrefID="ref74;ref75;ref76;ref77;ref78;ref79;" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable variableID="m3961" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="175.0" y="459.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="18.0" height="18.0" filePath="" fileType="internal" fileFormat="svg" outlineColor="0 0 0 0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" height="60.0" viewBox="0 0 60.0 60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;
&lt;radialGradient id="MO_932e3f" gradientUnits="objectBoundingBox" spreadMethod="pad" xlink:show="other" xlink:type="simple" r="50%" cx="50%" fx="50%" fy="50%" cy="50%" xlink:actuate="onLoad"&gt;
&lt;stop offset="0%" style="stop-color:white;stop-opacity:1;"/&gt;
&lt;stop offset="100%" style="stop-color:#932e3f;stop-opacity:1;"/&gt;
&lt;/radialGradient&gt;
&lt;/defs&gt;
&lt;path style="fill:url(#MO_932e3f);stroke:none;" d="M 60 48.54 l -0.3772 -11.808 c 13.6534 -12.4868 26.6272 14.8035 0.3772 -25.2737 l -11.9246 -3.3074 c -8.2669 -16.2079 23.0311 -19.5108 -25.1571 -8.1508 l -6.993 9.7635 c -18.7631 2.4691 -12.3928 -26.8612 -15.9253 20.2365 l 7.6025 9.3425 c -3.3288 17.7341 -30.6905 2.909 15.3149 20.6575 l 11.6914 -3.9898 c 16.7054 8.4916 -6.575 28.6596 25.3903 -7.4684 z" /&gt;
&lt;/svg&gt;</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e47" name="F protein" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable variableID="m48" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="96.0" y="398.5"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="23.999999999999996" height="18.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="34" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Extracellular">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e48" name="TLR4:F protein" type="cso30:c:Complex">
<csml:entitySimulationProperty>
<csml:variable variableID="m49" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="178.5" y="518.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="18.684279763209823" height="36.16312212234159" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="6" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e49" name="TLR4:F protein:MyD88:TIRAP" type="cso30:c:Complex">
<csml:entitySimulationProperty>
<csml:variable variableID="m63" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="175.0" y="585.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="18.264705882352942" height="30.44117647058823" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="31" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="MO000041132" name="TRAM" refUnificationXrefID="ref80;" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable variableID="m19005" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="10"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="364.0" y="336.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="16.0" height="16.0" filePath="" fileType="internal" fileFormat="svg" outlineColor="0 0 0 0">&lt;svg contentScriptType="text/ecmascript" width="60.0" xmlns:xlink="http://www.w3.org/1999/xlink" zoomAndPan="magnify" style="overflow:visible;enable-background:new 0 0 60.0 60.0" contentStyleType="text/css" height="60.0" viewBox="0 0 60.0 60.0" preserveAspectRatio="xMidYMid meet" xmlns="http://www.w3.org/2000/svg" version="1.0"&gt;
&lt;defs&gt;
&lt;radialGradient id="MO_6bc249" gradientUnits="objectBoundingBox" spreadMethod="pad" xlink:show="other" xlink:type="simple" r="50%" cx="50%" fx="50%" fy="50%" cy="50%" xlink:actuate="onLoad"&gt;
&lt;stop offset="0%" style="stop-color:white;stop-opacity:1;"/&gt;
&lt;stop offset="100%" style="stop-color:#6bc249;stop-opacity:1;"/&gt;
&lt;/radialGradient&gt;
&lt;/defs&gt;
&lt;path style="fill:url(#MO_6bc249);stroke:none;" d="M 60 48.5415 c 0.8103 -7.397 2.3214 -19.8066 -3.5398 -20.1631 c 9.5776 -10.3066 -2.5463 -7.5712 3.5398 -16.9193 c -7.1467 -3.0187 -19.0893 -8.2203 -21.2568 -3.0292 c -7.3468 -11.8479 -8.3579 -0.0366 -15.8253 -8.4299 c -5.2269 5.5315 -14.1193 14.7258 -9.5978 18.2907 c -14.118 2.984 -2.6193 7.5483 -13.3201 11.7096 c 3.9166 6.4373 10.3631 17.3217 15.3246 14.3334 c -1.3787 13.6923 6.7392 4.7019 7.5932 15.6663 c 7.6473 -1.5531 20.5241 -4.0206 19.0691 -9.4324 c 13.2666 5.4782 6.7842 -4.643 18.013 -2.0267 z" /&gt;
&lt;/svg&gt;</csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_CellComponent">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e63" name="TLR4:F protein:TRIF:TRAM" type="cso30:c:Complex">
<csml:entitySimulationProperty>
<csml:variable variableID="m64" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="174.0" y="676.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="19.058823529411768" height="31.764705882352942" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="31" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e64" name="A46" type="cso30:c:Protein">
<csml:entitySimulationProperty>
<csml:variable variableID="m65" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="241.0" y="864.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="14.228250701590275" height="32.83442469597755" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="36" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e65" name="TLR4:F protein:TRIF:TRAM:A46" type="cso30:c:Complex">
<csml:entitySimulationProperty>
<csml:variable variableID="m66" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="174.0" y="740.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="19.058823529411768" height="31.764705882352942" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="31" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e66" name="TLR4:F protein:MyD88:TIRAP:A46" type="cso30:c:Complex">
<csml:entitySimulationProperty>
<csml:variable variableID="m67" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="false"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="175.0" y="637.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="18.264705882352942" height="30.44117647058823" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="31" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e13" name="" type="cso30:c:EntityBiologicalCompartment">
<csml:entitySimulationProperty>
<csml:variable variableID="m13" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="true"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="655.0" y="197.0"/>
<csml:shape shapeID="default" depth="60" visible="true">
<csml:image width="257.4482392429785" height="429.8076536514135" filePath="system" fileType="resourceFile" fileFormat="svg" resourceID="20048" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_EndosomeMembrane">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e14" name="" type="cso30:c:EntityBiologicalCompartment">
<csml:entitySimulationProperty>
<csml:variable variableID="m14" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="true"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="655.0" y="197.0"/>
<csml:shape shapeID="default" depth="70" visible="true">
<csml:image width="257.4482392429785" height="429.8076536514135" filePath="system" fileType="resourceFile" fileFormat="svg" resourceID="20010" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Endosome">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e15" name="" type="cso30:c:EntityBiologicalCompartment">
<csml:entitySimulationProperty>
<csml:variable variableID="m15" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="true"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="655.0" y="197.0"/>
<csml:shape shapeID="default" depth="60" visible="true">
<csml:image width="257.4482392429785" height="429.8076536514135" filePath="system" fileType="resourceFile" fileFormat="svg" resourceID="20090" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_EndosomeLumen">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e3" name="" type="cso30:c:EntityBiologicalCompartment">
<csml:entitySimulationProperty>
<csml:variable variableID="m3" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="true"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="170.87518862352903" y="103.12209663264667"/>
<csml:shape shapeID="default" depth="71" visible="true">
<csml:image width="822.0090539293948" height="1209.0383168211513" filePath="system" fileType="resourceFile" fileFormat="svg" resourceID="20065" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e4" name="" type="cso30:c:EntityBiologicalCompartment">
<csml:entitySimulationProperty>
<csml:variable variableID="m4" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="true"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="202.55678757705792" y="133.09117672382234"/>
<csml:shape shapeID="default" depth="71" visible="true">
<csml:image width="758.6458560223374" height="1149.1001566387988" filePath="system" fileType="resourceFile" fileFormat="svg" resourceID="20066" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e2" name="" type="cso30:c:EntityBiologicalCompartment">
<csml:entitySimulationProperty>
<csml:variable variableID="m2" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="true"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="153.75" y="85.99690800911759"/>
<csml:shape shapeID="default" depth="71" visible="true">
<csml:image width="856.2594311764528" height="1243.2886940682085" filePath="system" fileType="resourceFile" fileFormat="svg" resourceID="20064" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e1" name="" type="cso30:c:EntityBiologicalCompartment">
<csml:entitySimulationProperty>
<csml:variable variableID="m1" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="true"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="153.75" y="85.99690800911759"/>
<csml:shape shapeID="default" depth="81" visible="true">
<csml:image width="856.2594311764528" height="1243.2886940682085" filePath="system" fileType="resourceFile" fileFormat="svg" resourceID="20003" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_PlasmaMembrane">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e54" name="" type="cso30:c:EntityBiologicalCompartment">
<csml:entitySimulationProperty>
<csml:variable variableID="m54" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="true"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="311.0" y="689.0"/>
<csml:shape shapeID="default" depth="50" visible="true">
<csml:image width="465.6500709748862" height="422.29345356567933" filePath="system" fileType="resourceFile" fileFormat="svg" resourceID="20111" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_NuclearOuterMembrane">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e60" name="" type="cso30:c:EntityBiologicalCompartment">
<csml:entitySimulationProperty>
<csml:variable variableID="m60" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="true"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="420.7511016961721" y="876.6637213250546"/>
<csml:shape shapeID="default" depth="30" visible="true">
<csml:image width="14.746453546866459" height="7.100144300343119" filePath="system" fileType="resourceFile" fileFormat="svg" resourceID="20043" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Chromatin">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e62" name="" type="cso30:c:EntityBiologicalCompartment">
<csml:entitySimulationProperty>
<csml:variable variableID="m62" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="true"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="441.43298634490145" y="914.5805098477247"/>
<csml:shape shapeID="default" depth="30" visible="true">
<csml:image width="7.878813199515761" height="7.8788131995157675" filePath="system" fileType="resourceFile" fileFormat="svg" resourceID="20115" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_NuclearCentromere">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e61" name="" type="cso30:c:EntityBiologicalCompartment">
<csml:entitySimulationProperty>
<csml:variable variableID="m61" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="true"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="420.25867587120234" y="855.4894108513561"/>
<csml:shape shapeID="default" depth="40" visible="true">
<csml:image width="50.4736470593979" height="90.85256470691624" filePath="system" fileType="resourceFile" fileFormat="svg" resourceID="20114" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_NuclearChromosome">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e56" name="" type="cso30:c:EntityBiologicalCompartment">
<csml:entitySimulationProperty>
<csml:variable variableID="m56" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="true"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="317.93705878547314" y="695.503492611381"/>
<csml:shape shapeID="default" depth="50" visible="true">
<csml:image width="451.7759534039399" height="409.2864683429171" filePath="system" fileType="resourceFile" fileFormat="svg" resourceID="20063" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Nucleoplasm">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e58" name="" type="cso30:c:EntityBiologicalCompartment">
<csml:entitySimulationProperty>
<csml:variable variableID="m58" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="true"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="574.6082338479803" y="983.8249983826097"/>
<csml:shape shapeID="default" depth="40" visible="true">
<csml:image width="82.37757307749382" height="74.57338194383664" filePath="system" fileType="resourceFile" fileFormat="svg" resourceID="20062" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Nucleolus">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e55" name="" type="cso30:c:EntityBiologicalCompartment">
<csml:entitySimulationProperty>
<csml:variable variableID="m55" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="true"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="311.0" y="689.0"/>
<csml:shape shapeID="default" depth="70" visible="true">
<csml:image width="465.6500709748862" height="422.29345356567933" filePath="system" fileType="resourceFile" fileFormat="svg" resourceID="20025" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_Nucleus">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e53" name="" type="cso30:c:EntityBiologicalCompartment">
<csml:entitySimulationProperty>
<csml:variable variableID="m53" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="true"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="317.93705878547314" y="695.503492611381"/>
<csml:shape shapeID="default" depth="60" visible="true">
<csml:image width="451.7759534039399" height="409.2864683429171" filePath="system" fileType="resourceFile" fileFormat="svg" resourceID="20113" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_NuclearLumen">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e52" name="" type="cso30:c:EntityBiologicalCompartment">
<csml:entitySimulationProperty>
<csml:variable variableID="m52" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="true"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="317.06992643728904" y="694.6363602631969"/>
<csml:shape shapeID="default" depth="50" visible="true">
<csml:image width="453.51021810030846" height="411.0207330392853" filePath="system" fileType="resourceFile" fileFormat="svg" resourceID="20110" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_NuclearInnerMembrane">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e57" name="" type="cso30:c:EntityBiologicalCompartment">
<csml:entitySimulationProperty>
<csml:variable variableID="m57" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="true"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="650.9158804881849" y="862.4264696368292"/>
<csml:shape shapeID="default" depth="40" visible="true">
<csml:image width="29.091257918298922" height="26.33524401024959" filePath="system" fileType="resourceFile" fileFormat="svg" resourceID="20117" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_NuclearBody">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e59" name="" type="cso30:c:EntityBiologicalCompartment">
<csml:entitySimulationProperty>
<csml:variable variableID="m59" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="true"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="311.0" y="689.0"/>
<csml:shape shapeID="default" depth="60" visible="true">
<csml:image width="465.6500709748862" height="422.29345356567933" filePath="system" fileType="resourceFile" fileFormat="svg" resourceID="20022" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_NuclearEnvelope">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e51" name="" type="cso30:c:EntityBiologicalCompartment">
<csml:entitySimulationProperty>
<csml:variable variableID="m51" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="true"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="361.29367619468036" y="699.0077409313898"/>
<csml:shape shapeID="default" depth="50" visible="true">
<csml:image width="272.27955732982184" height="409.2864683429171" filePath="system" fileType="resourceFile" fileFormat="svg" resourceID="20021" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_NuclearPore">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
<csml:entity id="e50" name="" type="cso30:c:EntityBiologicalCompartment">
<csml:entitySimulationProperty>
<csml:variable variableID="m50" type="csml-variable:Double">
<csml:parameter key="csml-variable:parameter:initialValue" value="0"/>
<csml:parameter key="csml-variable:parameter:maximumValue" value="infinite"/>
<csml:parameter key="csml-variable:parameter:minimumValue" value="0"/>
<csml:parameter key="csml-variable:parameter:global" value="true"/>
</csml:variable>
</csml:entitySimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="311.0" y="689.0"/>
<csml:shape shapeID="default" depth="50" visible="true">
<csml:image width="465.6500709748862" height="422.29345356567933" filePath="system" fileType="resourceFile" fileFormat="svg" resourceID="20112" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refCellComponentID="cso30:i:CC_NuclearEnvelopeLumen">
<csml:property key="probeID" value=""/>
<csml:property key="extension" value=""/>
<csml:property key="accession" value=""/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:entity>
</csml:entitySet>
<csml:processSet>
<csml:process id="p1" name="p1" type="cso30:c:ProcessBiological">
<csml:connector id="c1" name="c1" refID="MO000022224" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="357.0" y="70.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="357.0 70.0 372.63631189772843 103.74151514772976" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="375.3582437173298 102.48013210937792 369.9143800781271 105.00289818608161 376.00000000000006 111.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c2" name="c2" refID="MO000008179" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="352.0" y="135.48127556231887"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="352.0 194.0 374.16618349912164 135.48127556231887" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="371.3607051632521 134.4185943744895 376.9716618349912 136.54395675014825 377.0 128.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c3" name="c3" refID="MO000022225" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="387.0" y="128.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="387.0 128.0 438.94858925432345 191.7965131193446" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="441.27489683456923 189.9022340897159 436.62228167407767 193.69079214897332 444.0 198.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="371.0" y="111.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="17.0" height="17.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="10005" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_Binding" refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="edgeScore" value="1.0"/>
<csml:property key="relationType" value="Type 0"/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
PMID: 17223961
The first viral PRR to be proposed was PKR, an intracellular detector of dsRNA and polyinosinic&#8211;polycytdylic acid (poly(I:C) (a synthetic dsRNA widely used to mimic viral infection).</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p2" name="p1" type="cso30:c:ProcessBiological">
<csml:connector id="c4" name="c4" refID="e5" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="442.0" y="62.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="442.0 62.0 446.1165477914012 99.04893012261105" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="449.0981989954221 98.71763554438651 443.13489658738035 99.38022470083558 447.0 107.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c5" name="c5" refID="MO000008179" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="358.0" y="129.27329302959447"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="358.0 195.0 432.98398964229364 129.27329302959447" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="431.0065047561957 127.01728914545458 434.96147452839153 131.52929691373436 439.0 124.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c6" name="c6" refID="e6" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="456.0" y="124.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="456.0 124.0 521.1816226303969 185.50941853854349" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="523.240590678443 183.3275270249423 519.1226545823506 187.69131005214467 527.0 191.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="439.0" y="107.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="17.0" height="17.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="10005" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_Binding" refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="edgeScore" value="1.0"/>
<csml:property key="relationType" value="Type 0"/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
PMID: 17223961
The first viral PRR to be proposed was PKR, an intracellular detector of dsRNA and polyinosinic&#8211;polycytdylic acid (poly(I:C) (a synthetic dsRNA widely used to mimic viral infection).</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p3" name="p3" type="cso30:c:ProcessBiological">
<csml:connector id="c7" name="c7" refID="e11" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="419.0" y="275.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="419.0 275.0 459.32181856674134 301.5952420333826" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="460.9736028042229 299.0909239959106 457.6700343292598 304.0995600708546 466.0 306.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c9" name="c9" refID="MO000022225" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="454.0" y="218.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:associationConnector name="default" depth="0" points="454.0 218.0 472.14703578155166 294.21755028251704" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="475.06545442560775 293.5226887005989 469.2286171374956 294.91241186443517 474.0 301.99999999999994"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
indirect</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c8" name="c8" refID="e12" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="459.85819745644653" y="321.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="474.0 321.0 459.85819745644653 380.21879815113016" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="462.7761481497727 380.91562219729764 456.94024676312034 379.52197410496274 458.0 388.00000000000006"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="466.0" y="302.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="19.0" height="19.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="10001" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_Phosphorylation" refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="edgeScore" value="1.0"/>
<csml:property key="relationType" value="Type 0"/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
PMID: 17223961
A key function of PKR is to inhibit translation of host cell mRNA under conditions of viral invasion by phosphorylating the translation initiation factor eIF2alpha</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p4" name="p3" type="cso30:c:ProcessBiological">
<csml:connector id="c10" name="c10" refID="e6" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="536.0" y="212.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:associationConnector name="default" depth="0" points="536.0 212.0 536.0 250.0" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="539.0 250.0 533.0 250.0 536.0 258.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
indirect</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c11" name="c11" refID="e11" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="419.0" y="268.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="419.0 268.0 518.0 268.0" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="518.0 265.0 518.0 271.0 526.0 268.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c12" name="c12" refID="e12" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="465.223472969005" y="277.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="530.0 277.0 465.223472969005 381.20571739768764" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="467.77132894487215 382.7895197610645 462.6756169931379 379.6219150343108 461.00000000000006 388.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="526.0" y="258.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="19.0" height="19.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="10001" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_Phosphorylation" refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="edgeScore" value="1.0"/>
<csml:property key="relationType" value="Type 0"/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
PMID: 17223961
A key function of PKR is to inhibit translation of host cell mRNA under conditions of viral invasion by phosphorylating the translation initiation factor eIF2alpha</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p5" name="p5" type="cso30:c:ProcessBiological">
<csml:connector id="c13" name="c13" refID="e5" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="458.0" y="62.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="458.0 62.0 578.6664311212271 155.11267913291545" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="580.4991764463838 152.73759080337564 576.8336857960703 157.48776746245528 584.9999999999999 160.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c14" name="c14" refID="MO000019398" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="613.2613881364466" y="176.35741602007747"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="699.0 216.0 613.2613881364466 176.35741602007747" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="612.0023571289175 179.08043657124495 614.5204191439756 173.63439546891001 606.0 173.00000000000003"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c15" name="c15" refID="e16" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="603.0" y="178.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="603.0 178.0 656.490893360564 256.3918264766886" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="658.9689584318057 254.7009114869001 654.0128282893222 258.0827414664771 661.0 263.00000000000006"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="585.0" y="157.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="21.0" height="21.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="10005" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_Binding" refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="edgeScore" value="1.0"/>
<csml:property key="relationType" value="Type 0"/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
PMID: 17223961,15961631,16043704
Although there is still no direct evidence of viral dsRNA binding to TLR3, both Choe et al. and Bell et al. showed that synthetic dsRNA [including poly(I:C)] could indeed bind to the ectodomain. </csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p6" name="p6" type="cso30:c:ProcessBiological">
<csml:connector id="c16" name="c16" refID="e17" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="111.0" y="130.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="111.0 130.0 120.05971499970934 166.23885999883734" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="122.97014250014534 165.51125312372835 117.14928749927336 166.96646687394636 122.00000000000001 174.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c17" name="c17" refID="MO000019397" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="139.32765345276295" y="136.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="186.0 136.0 139.32765345276295 172.1050228006928" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="141.16326990250315 174.47789284547892 137.49203700302274 169.73215275590672 133.0 177.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c18" name="c18" refID="e18" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="133.0" y="191.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="133.0 191.0 172.5665908682694 220.24487151132956" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="174.34976405152082 217.8323430869306 170.78341768501798 222.65739993572853 179.0 225.00000000000003"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="114.0" y="174.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="19.0" height="19.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="10005" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_Binding" refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="edgeScore" value="1.0"/>
<csml:property key="relationType" value="Type 0"/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
PMID: 17223961
Similarly, TLR2 has been shown to mediate cellular responses to viral glycoproteins.</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p7" name="p7" type="cso30:c:ProcessBiological">
<csml:connector id="c19" name="c19" refID="MO000042012" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="854.0" y="280.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="854.0 280.0 962.0 280.0" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="962.0 277.0 962.0 283.0 970.0 280.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c20" name="c20" refID="e19" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="996.876086539512" y="265.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="1062.0 265.0 996.876086539512 276.5974092463883" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="997.4020580721165 279.5509416987053 996.3501150069077 273.6438767940713 989.0 278.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c21" name="c21" refID="e20" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="885.1554175279994" y="285.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="970.0 285.0 885.1554175279994 327.4222912360003" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="886.4970583144992 330.1055728090001 883.8137767414995 324.73900966300056 878.0 331.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="970.0" y="270.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="19.0" height="19.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="10005" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_Binding" refCellComponentID="cso30:i:CC_Extracellular">
<csml:property key="edgeScore" value="1.0"/>
<csml:property key="relationType" value="Type 0"/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
PMID: 17223961,11130078
TLR9 was shown originally to be activated by bacterial DNA sequences containing unmethylated CpG dinucleotides </csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p8" name="p8" type="cso30:c:ProcessBiological">
<csml:connector id="c22" name="c22" refID="MO000042126" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="890.0" y="393.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="890.0 393.0 950.0851269170812 401.8360480760413" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="950.5216088885657 398.86797066994677 949.6486449455966 404.8041254821359 958.0 403.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c23" name="c23" refID="e21" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="985.0" y="404.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="1070.0 404.0 985.0 404.0" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="985.0 407.0 985.0 401.0 977.0 404.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c24" name="c24" refID="e22" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="884.5318292445987" y="408.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="958.0 408.0 884.5318292445987 434.3034191593412" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="885.5430470598458 437.1278551260657 883.5206114293517 431.4789831926167 877.0 437.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="958.0" y="394.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="19.0" height="19.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="10005" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_Binding" refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="edgeScore" value="1.0"/>
<csml:property key="relationType" value="Type 0"/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
PMID: 17223961
TLR7 and TLR8, which are related more closely to TLR9 than to other TLRs in terms of sequence similarity, also act in endosomes where they have been shown to trigger gene induction in response to viral ssRNA.</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p9" name="p8" type="cso30:c:ProcessBiological">
<csml:connector id="c25" name="c25" refID="MO000042007" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="882.0" y="480.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="882.0 480.0 946.0 480.0" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="946.0 477.0 946.0 483.0 954.0 480.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c26" name="c26" refID="e21" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="979.9962562338314" y="414.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="1083.0 414.0 979.9962562338314 471.1202579066935" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="981.4511595188214 473.7438539943803 978.5413529488416 468.4966618190067 973.0 475.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c27" name="c27" refID="e23" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="864.1993955485456" y="485.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="954.0 485.0 864.1993955485456 528.5116330847253" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="865.5075331417736 531.2114064154299 862.8912579553177 525.8118597540207 857.0000000000001 532.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="954.0" y="470.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="19.0" height="19.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="10005" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_Binding" refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="edgeScore" value="1.0"/>
<csml:property key="relationType" value="Type 0"/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
PMID: 17223961
TLR7 and TLR8, which are related more closely to TLR9 than to other TLRs in terms of sequence similarity, also act in endosomes where they have been shown to trigger gene induction in response to viral ssRNA.</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p10" name="p10" type="cso30:c:ProcessBiological">
<csml:connector id="c28" name="c28" refID="e24" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="380.5838051064926" y="735.9786697887325"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:associationConnector name="default" depth="0" points="383.0 769.0 380.5838051064926 735.9786697887325" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="377.5918039357179 736.1975967036673 383.5758062772673 735.7597428737978 380.0 728.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
indirect</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c30" name="c30" refID="e12" type="cso30:c:InputInhibitor">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="382.913328934415" y="404.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:inhibitoryConnector name="default" depth="0" points="454.0 404.0 382.913328934415 707.1056669046471" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<bioInhibitoryConnectorArrow size="4.0 14.0" pointsInAbsoluteCoordinate="389.7284118512825 708.7039925398734 376.0982460175476 705.507341269421 375.1849170831326 709.4016743647737 388.8150829168675 712.5983256352263"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c29" name="c29" refID="e25" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="352.90697358120497" y="722.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="371.0 722.0 352.90697358120497 724.7835425259685" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="353.3631451339668 727.7486576189203 352.45080202844315 721.8184274330166 345.0 726.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="371.0" y="711.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="17.0" height="17.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="10031" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_Translation" refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="edgeScore" value="1.0"/>
<csml:property key="relationType" value="Type 0"/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
PMID: 17223961
A key function of PKR is to inhibit translation of host cell mRNA under conditions of viral invasion by phosphorylating the translation initiation factor eIF2alpha

</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p11" name="p11" type="cso30:c:ProcessBiological">
<csml:connector id="c31" name="c31" refID="e18" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="197.0" y="232.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="197.0 232.0 226.0 232.0" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="226.0 229.0 226.0 235.0 234.0 232.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c32" name="c32" refID="MO000016573" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="253.96911150685466" y="187.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="270.0 187.0 253.96911150685466 215.05405486300432" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="256.57384093322804 216.54247167807483 251.36438208048128 213.56563804793382 250.0 222.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c33" name="c33" refID="MO000022528" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="244.0" y="249.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="244.0 295.0 244.0 249.0" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="241.0 249.0 247.0 249.0 244.0 241.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c34" name="c34" refID="e26" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="201.51724137931035" y="241.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="236.0 241.0 201.51724137931035 277.2068965517241" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="203.6896551724138 279.2758620689655 199.34482758620692 275.1379310344828 196.00000000000003 283.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="234.0" y="222.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="19.0" height="19.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="10005" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_Binding" refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="edgeScore" value="1.0"/>
<csml:property key="relationType" value="Type 0"/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
PMID: 17223961
The five TIR adaptors, MyD88, Mal, TRIF, TRAM and SARM, are differentially utiilized by TLRs leading to different signalling specificities, Table3

PMID: 17223961
TRAM is uniquely utilized by TLR4 for both NF-KappaB and IRF3 activation, while Mal has been shown to have a role in NF-KappaB activation for both TLR4 and TLR2.</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p12" name="p12" type="cso30:c:ProcessBiological">
<csml:connector id="c35" name="c35" refID="e26" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="196.0" y="305.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:associationConnector name="default" depth="0" points="196.0 305.0 427.6580176236985 483.1236017862892" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="429.4866669538401 480.74535839517614 425.829368293557 485.50184517740223 434.0 487.99999999999994"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
indirect</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c36" name="c36" refID="e27" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="385.0" y="499.75230673845374"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="385.0 509.0 426.19426998325144 499.75230673845374" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="425.5371549563313 496.82515798217304 426.8513850101716 502.67945549473444 434.0 498.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c182" name="c182" refID="e46" type="cso30:c:InputInhibitor">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="334.0" y="448.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:inhibitoryConnector depth="0" points="334.0 448.0 430.3387398703089 490.38904554293595" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<bioInhibitoryConnectorArrow size="4.0 14.0" pointsInAbsoluteCoordinate="433.157910170171 483.98184031597657 427.5195695704468 496.79625076989527 431.18082970013785 498.4072052269594 436.8191702998621 485.5927947730406"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:connector id="c37" name="c37" refID="MO000000058" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="422.5664562694431" y="505.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="441.0 505.0 422.5664562694431 559.4228433949775" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="425.40788999632656 560.3852644960186 419.72502254255966 558.4604222939363 420.0 567.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="434.0" y="486.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="19.0" height="19.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="10003" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_UnknownActivation" refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="edgeScore" value="1.0"/>
<csml:property key="relationType" value="Type 0"/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
PMID: 17223961
The five TIR adaptors, MyD88, Mal, TRIF, TRAM and SARM, are differentially utiilized by TLRs leading to different signalling specificities, Table3

PMID: 17223961
TRAM is uniquely utilized by TLR4 for both NF-KappaB and IRF3 activation, while Mal has been shown to have a role in NF-KappaB activation for both TLR4 and TLR2.

PMID: 17223961,12566418,15767367
A52 can interact with both TRAF6 and IRAK2 and inhibit TLR-induced NFKappaB activation, especially for TLR3 , while A46 can interact with human MyD88, Mal, TRIF and TRAM and thus inhibit both TLR-induced NF&#954;B and IRF activation, although it has less of an effect on TLR3-induced NFKappaB activation than A52</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p13" name="p13" type="cso30:c:ProcessBiological">
<csml:connector id="c38" name="c38" refID="e16" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="602.0" y="280.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="661.0 280.0 602.0 280.0" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="602.0 283.0 602.0 277.0 594.0 280.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c39" name="c39" refID="MO000041125" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="552.0" y="297.2299027111483"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="552.0 347.0 575.5753092420877 297.2299027111483" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="572.8640957254071 295.9456436769312 578.2865227587683 298.51416174536547 579.0 290.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c40" name="c40" refID="e28" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="594.0" y="287.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="594.0 287.0 658.2859769622524 328.65006958117766" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="659.9172008693108 326.13231094202234 656.6547530551941 331.167828220333 665.0 333.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="573.0" y="269.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="21.0" height="21.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="10005" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_Binding" refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="edgeScore" value="1.0"/>
<csml:property key="relationType" value="Type 0"/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p14" name="p14" type="cso30:c:ProcessBiological">
<csml:connector id="c41" name="c41" refID="e28" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="571.2469504755443" y="349.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:associationConnector name="default" depth="0" points="665.0 349.0 571.2469504755443 424.0024396195646" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="573.1210356182075 426.3450460478937 569.372865332881 421.6598331912355 565.0 429.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
indirect</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c42" name="c42" refID="MO000007694" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="479.0" y="436.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="479.0 436.0 538.0 436.0" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="538.0 433.0 538.0 439.0 546.0 436.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c43" name="c43" refID="e29" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="537.8466608896548" y="445.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="551.0 445.0 537.8466608896548 468.98550073062944" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="540.4770981156688 470.42799856425 535.2162236636409 467.5430028970089 534.0 476.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="546.0" y="426.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="19.0" height="19.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="10003" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_UnknownActivation" refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="edgeScore" value="1.0"/>
<csml:property key="relationType" value="Type 0"/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
PMID: 17223961
The five TIR adaptors, MyD88, Mal, TRIF, TRAM and SARM, are differentially utiilized by TLRs leading to different signalling specificities, Table3

PMID: 17223961,16932750
Importantly, TRIF is also the sole adaptor used by TLR3, leading to activation of IRF3, IRF7 and NFKappaB </csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p15" name="p14" type="cso30:c:ProcessBiological">
<csml:connector id="c44" name="c44" refID="e28" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="645.6471701423768" y="357.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:associationConnector name="default" depth="0" points="670.0 357.0 645.6471701423768 426.45066292729564" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="648.478171544641 427.44335173068697 642.8161687401127 425.4579741239043 643.0 434.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
indirect</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c45" name="c45" refID="MO000007700" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="600.0" y="460.4605447861927"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="600.0 546.0 633.1120471795383 460.4605447861927" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="630.314342884716 459.37756247851956 635.9097514743605 461.54352709386586 636.0 453.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c46" name="c46" refID="e30" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="643.0" y="453.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="643.0 453.0 710.543977760618 662.3863310579156" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="713.3991036138996 661.4653227181474 707.6888519073362 663.3073393976839 713.0 670.0000000000001"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="630.0" y="434.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="19.0" height="19.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="10003" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_UnknownActivation" refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="edgeScore" value="1.0"/>
<csml:property key="relationType" value="Type 0"/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
PMID: 17223961
The five TIR adaptors, MyD88, Mal, TRIF, TRAM and SARM, are differentially utiilized by TLRs leading to different signalling specificities, Table3

PMID: 17223961,16932750
Importantly, TRIF is also the sole adaptor used by TLR3, leading to activation of IRF3, IRF7 and NFKappaB </csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p16" name="p14" type="cso30:c:ProcessBiological">
<csml:connector id="c47" name="c47" refID="e28" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="567.5816675103376" y="356.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:associationConnector name="default" depth="0" points="665.0 356.0 567.5816675103376 495.44192689696763" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="570.0409449239747 497.1600522133443 565.1223900967004 493.72380158059104 562.9999999999999 502.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
indirect</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c48" name="c48" refID="MO000007702" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="519.0" y="528.7152317131197"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="519.0 645.0 550.884533239951 528.7152317131197" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="547.9913213475311 527.9219316781014 553.7777451323709 529.5085317481381 552.9999999999999 521.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c49" name="c49" refID="e31" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="558.0" y="521.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="558.0 521.0 587.1709740647999 645.2118895662448" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="590.0915154774581 644.5260048405448 584.2504326521417 645.8977742919449 589.0 653.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="546.0" y="502.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="19.0" height="19.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="10003" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_UnknownActivation" refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="edgeScore" value="1.0"/>
<csml:property key="relationType" value="Type 0"/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
PMID: 17223961
The five TIR adaptors, MyD88, Mal, TRIF, TRAM and SARM, are differentially utiilized by TLRs leading to different signalling specificities, Table3

PMID: 17223961,16932750
Importantly, TRIF is also the sole adaptor used by TLR3, leading to activation of IRF3, IRF7 and NFKappaB </csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p17" name="p17" type="cso30:c:ProcessBiological">
<csml:connector id="c50" name="c50" refID="MO000000058" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="420.0" y="593.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:associationConnector name="default" depth="0" points="420.0 593.0 501.5405561353334 845.3874356569843" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="504.3952677639643 844.4651442077343 498.68584450670255 846.3097271062343 504.0 853.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
indirect</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c51" name="c51" refID="G010262" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="468.08084319674055" y="874.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="500.0 874.0 468.08084319674055 912.8205961120723" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="470.3981196547134 914.7259123108499 465.7635667387677 910.9152799132945 463.0 918.9999999999999"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="497.0" y="853.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="21.0" height="21.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="10068" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_GeneExpression" refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="edgeScore" value="1.0"/>
<csml:property key="relationType" value="Type 0"/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
PMID: 17223961
Table 3

</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p18" name="p17" type="cso30:c:ProcessBiological">
<csml:connector id="c52" name="c52" refID="e29" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="529.0" y="499.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:associationConnector name="default" depth="0" points="529.0 499.0 539.6321885264988 730.0084598030192" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="542.6290161003666 729.8705305004562 536.6353609526309 730.1463891055821 540.0 738.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
indirect</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c53" name="c53" refID="G010228" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="541.0" y="757.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="541.0 757.0 550.1447151510638 842.0458509048937" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="553.1275210617287 841.7251190865426 547.1619092403989 842.3665827232447 551.0 849.9999999999999"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="530.0" y="738.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="19.0" height="19.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="10068" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_GeneExpression" refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="edgeScore" value="1.0"/>
<csml:property key="relationType" value="Type 0"/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
PMID: 17223961
Table 3

</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p19" name="p17" type="cso30:c:ProcessBiological">
<csml:connector id="c54" name="c54" refID="e31" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="594.0" y="675.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:associationConnector name="default" depth="0" points="594.0 675.0 604.7985912732382 746.090725882152" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="607.7645690674312 745.6401976096164 601.8326134790452 746.5412541546876 606.0 754.0000000000001"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
indirect</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c55" name="c55" refID="G010228" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="563.9005376398869" y="773.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="603.0 773.0 563.9005376398869 843.0153163192722" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="566.5197940201598 844.4780179342298 561.2812812596139 841.5526147043146 559.9999999999999 850.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="598.0" y="754.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="19.0" height="19.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="10068" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_GeneExpression" refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="edgeScore" value="1.0"/>
<csml:property key="relationType" value="Type 0"/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
PMID: 17223961
Table 3

</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p20" name="p17" type="cso30:c:ProcessBiological">
<csml:connector id="c56" name="c56" refID="e30" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="624.9425724154552" y="690.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:associationConnector name="default" depth="0" points="708.0 690.0 624.9425724154552 795.7094532894206" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="627.3015274319224 797.5629179452163 622.5836173989878 793.8559886336249 619.9999999999999 802.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
indirect</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c57" name="c57" refID="G010228" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="572.0621504188273" y="821.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="602.0 821.0 572.0621504188273 846.779814917121" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="574.0197198249069 849.0531213241812 570.1045810127476 844.5065085100608 566.0 852.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="602.0" y="802.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="19.0" height="19.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="10068" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_GeneExpression" refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="edgeScore" value="1.0"/>
<csml:property key="relationType" value="Type 0"/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
PMID: 17223961
Table 3

</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p21" name="p17" type="cso30:c:ProcessBiological">
<csml:connector id="c58" name="c58" refID="MO000000058" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="416.0" y="593.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:associationConnector name="default" depth="0" points="416.0 593.0 416.0 774.0" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="419.0 774.0 413.0 774.0 416.0 782.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
indirect</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c59" name="c59" refID="G010657" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="413.5699763999033" y="801.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="415.0 801.0 413.5699763999033 821.0203304013542" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="416.5623524993955 821.2340715513179 410.57760030041106 820.8065892513905 413.0 829.0000000000001"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="406.0" y="782.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="19.0" height="19.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="10068" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_GeneExpression" refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="edgeScore" value="1.0"/>
<csml:property key="relationType" value="Type 0"/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
PMID: 17223961
Table 3

</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p22" name="p17" type="cso30:c:ProcessBiological">
<csml:connector id="c60" name="c60" refID="MO000000058" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="418.0" y="593.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:associationConnector name="default" depth="0" points="418.0 593.0 476.67405844466185 942.1106477457381" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="479.6325655400101 941.6134196624863 473.71555134931367 942.6078758289899 478.0 950.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
indirect</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c61" name="c61" refID="G010329" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="449.76114000116263" y="962.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="470.0 962.0 449.76114000116263 967.0597149997093" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="450.48874687627165 969.9701425001452 449.03353312605367 964.1492874992732 442.0 968.9999999999999"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="470.0" y="950.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="19.0" height="19.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="10068" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_GeneExpression" refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="edgeScore" value="1.0"/>
<csml:property key="relationType" value="Type 0"/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
PMID: 17223961
Table 3

</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p23" name="p17" type="cso30:c:ProcessBiological">
<csml:connector id="c62" name="c62" refID="MO000000058" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="422.0" y="593.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:associationConnector name="default" depth="0" points="422.0 593.0 483.4001554928838 714.855693208954" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="486.079270539526 713.5057515187855 480.72104044624155 716.2056348991226 486.99999999999994 722.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
indirect</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c63" name="c63" refID="G010522" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="495.0" y="741.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="495.0 741.0 501.38311548893466 759.4401114124779" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="504.21807370925546 758.4587797208284 498.5481572686139 760.4214431041273 504.0 766.9999999999999"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="482.0" y="722.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="19.0" height="19.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="10068" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_GeneExpression" refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="edgeScore" value="1.0"/>
<csml:property key="relationType" value="Type 0"/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
PMID: 17223961
Table 3

</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p24" name="p24" type="cso30:c:ProcessBiological">
<csml:connector id="c65" name="c65" refID="MO000016573" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="287.0" y="186.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="287.0 186.0 779.0048116683882 620.7030464539977" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="780.9911692481392 618.4548508296433 777.0184540886374 622.9512420783522 785.0 626.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c64" name="c64" refID="e20" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="800.8658978935465" y="354.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="864.0 354.0 800.8658978935465 617.2206410899831" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="803.7831574848028 617.920352800063 797.9486383022902 616.5209293799031 799.0 625.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c66" name="c66" refID="e32" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="775.4206330594147" y="569.6249941371564"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="793.0 625.0 775.4206330594147 569.6249941371564" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="772.5612602579811 570.5327315344368 778.2800058608483 568.7172567398758 773.0 562.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="785.0" y="625.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="21.0" height="21.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="10005" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_Binding" refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="edgeScore" value="1.0"/>
<csml:property key="relationType" value="Type 0"/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
PMID: 17223961
Table 3

PMID: 17223961,15665823,16006187
It was shown originally to be essential for signalling to TLR-induced NFKappaB activation, but was also shown subsequently to be required for TLR-induced IRF5 activation, and for TLR7- and TLR9-induced IRF7 activation</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p25" name="p25" type="cso30:c:ProcessBiological">
<csml:connector id="c67" name="c67" refID="e32" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="643.2931332664081" y="553.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:associationConnector name="default" depth="0" points="758.0 553.0 643.2931332664081 604.7121120520292" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="644.5260912468972 607.4470370269322 642.0601752859191 601.9771870771261 636.0 608.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
indirect</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c68" name="c68" refID="MO000007700" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="602.0" y="566.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="602.0 566.0 619.0511558443329 596.0425126781104" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="621.6602135900415 594.5616961197352 616.4420980986243 597.5233292364854 623.0 602.9999999999999"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c69" name="c69" refID="e30" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="636.0" y="618.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="636.0 618.0 699.6657419554922 667.1135723656654" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="701.4981523183676 664.738225598975 697.8333315926167 669.4889191323558 705.9999999999999 672.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="619.0" y="603.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="17.0" height="17.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="10003" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_UnknownActivation" refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="edgeScore" value="1.0"/>
<csml:property key="relationType" value="Type 0"/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
PMID: 17223961
Table 3 </csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p26" name="p25" type="cso30:c:ProcessBiological">
<csml:connector id="c70" name="c70" refID="e32" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="571.8351867815206" y="550.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:associationConnector name="default" depth="0" points="758.0 550.0 571.8351867815206 588.3844975708205" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="572.441000192463 591.3226926138907 571.2293733705784 585.4463025277503 564.0000000000001 590.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
indirect</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c71" name="c71" refID="MO000007702" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="523.0" y="606.7924528301887"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="523.0 645.0 546.7735849056604 606.7924528301887" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="544.2264150943397 605.2075471698114 549.3207547169812 608.377358490566 551.0000000000001 600.0000000000001"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c72" name="c72" refID="e31" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="560.0" y="600.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="560.0 600.0 583.3685937486489 645.8716840251257" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="586.0417122392267 644.509906680869 580.695475258071 647.2334613693823 586.9999999999999 653.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="547.0" y="583.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="17.0" height="17.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="10003" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_UnknownActivation" refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="edgeScore" value="1.0"/>
<csml:property key="relationType" value="Type 0"/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
PMID: 17223961
Table 3 </csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p27" name="p25" type="cso30:c:ProcessBiological">
<csml:connector id="c73" name="c73" refID="e32" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="503.9811865548803" y="529.5483257938467"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:associationConnector name="default" depth="0" points="758.0 547.0 503.9811865548803 529.5483257938467" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="503.7755643821878 532.5412707519268 504.18680872757284 526.5553808357666 496.0 529.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
indirect</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c74" name="c74" refID="e27" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="385.0" y="514.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="385.0 514.0 471.0754249637075 525.9040481332787" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="471.486406913728 522.932332494669 470.664443013687 528.8757637718884 479.0 527.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c183" name="c183" refID="e46" type="cso30:c:InputInhibitor">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="334.0" y="449.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:inhibitoryConnector depth="0" points="334.0 449.0 475.4371555452092 521.1817207610034" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<bioInhibitoryConnectorArrow size="4.0 14.0" pointsInAbsoluteCoordinate="478.6191442134534 514.9467429651195 472.255166876965 527.4166985568874 475.8180113317558 529.234977795884 482.18198866824423 516.7650222041161"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:connector id="c75" name="c75" refID="MO000000058" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="435.49227473161193" y="535.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="479.0 535.0 435.49227473161193 566.3255621932394" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="437.24518890914715 568.7601652175939 433.7393605540767 563.8909591688849 428.99999999999994 571.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="479.0" y="519.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="17.0" height="17.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="10003" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_UnknownActivation" refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="edgeScore" value="1.0"/>
<csml:property key="relationType" value="Type 0"/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
PMID: 17223961
Table 3 

PMID: 17223961,12566418,15767367
A52 can interact with both TRAF6 and IRAK2 and inhibit TLR-induced NFKappaB activation, especially for TLR3 , while A46 can interact with human MyD88, Mal, TRIF and TRAM and thus inhibit both TLR-induced NF&#954;B and IRF activation, although it has less of an effect on TLR3-induced NFKappaB activation than A52</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p28" name="p25" type="cso30:c:ProcessBiological">
<csml:connector id="c76" name="c76" refID="e32" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="757.7882251601028" y="562.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:associationConnector name="default" depth="0" points="767.0 562.0 757.7882251601028 655.0389258829615" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="760.7736279539922 655.3345103180001 754.8028223662133 654.743341447923 756.9999999999999 663.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
indirect</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c77" name="c77" refID="MO000007685" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="771.4623850752448" y="677.8831942336172"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="808.0 692.0 771.4623850752448 677.8831942336172" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="770.3811872376383 680.681588636834 772.5435829128513 675.0847998304005 764.0 674.9999999999999"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c78" name="c78" refID="e33" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="760.0" y="680.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="760.0 680.0 794.4222912360003 748.8445824720006" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="797.105572809 747.5029416855008 791.7390096630005 750.1862232585005 797.9999999999999 756.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="747.0" y="663.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="17.0" height="17.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="10003" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_UnknownActivation" refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="edgeScore" value="1.0"/>
<csml:property key="relationType" value="Type 0"/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
PMID: 17223961
Table 3 </csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p29" name="p29" type="cso30:c:ProcessBiological">
<csml:connector id="c79" name="c79" refID="e33" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="640.3722099360788" y="773.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:associationConnector name="default" depth="0" points="792.0 773.0 640.3722099360788 836.893471284797" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="641.5371582042799 839.6580500108265 639.2072616678776 834.1288925587675 632.9999999999999 840.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
indirect</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c80" name="c80" refID="G010228" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="573.7218109753595" y="847.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="614.0 847.0 573.7218109753595 857.9086761941735" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="574.5060574025445 860.8043553099333 572.9375645481746 855.0129970784136 566.0 860.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="614.0" y="834.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="19.0" height="19.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="10068" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_GeneExpression" refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="edgeScore" value="1.0"/>
<csml:property key="relationType" value="Type 0"/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
PMID: 17223961,17018642
Most recently it has been shown that in myeloid DCs, TLR9-induced IFN-&#946;, IL-12 and inducible macrophage type nitric oxide synthase (iNOS) is dependent on MyD88-mediated IRF1 activation</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p30" name="p29" type="cso30:c:ProcessBiological">
<csml:connector id="c81" name="c81" refID="e33" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="700.9425724154552" y="780.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:associationConnector name="default" depth="0" points="795.0 780.0 700.9425724154552 899.7094532894206" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="703.3015274319224 901.5629179452163 698.5836173989878 897.8559886336249 695.9999999999999 906.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
indirect</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c82" name="c82" refID="G010514" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="628.5074104802507" y="925.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="679.0 925.0 628.5074104802507 978.197549672593" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="630.6833293530283 980.262828602687 626.331491607473 976.132270742499 623.0 984.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="678.0" y="906.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="19.0" height="19.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="10068" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_GeneExpression" refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="edgeScore" value="1.0"/>
<csml:property key="relationType" value="Type 0"/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
PMID: 17223961,17018642
Most recently it has been shown that in myeloid DCs, TLR9-induced IFN-&#946;, IL-12 and inducible macrophage type nitric oxide synthase (iNOS) is dependent on MyD88-mediated IRF1 activation</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p31" name="p29" type="cso30:c:ProcessBiological">
<csml:connector id="c83" name="c83" refID="e33" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="532.0741663966368" y="774.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:associationConnector name="default" depth="0" points="792.0 774.0 532.0741663966368 911.2642042624502" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="533.4750897982179 913.917016661189 530.6732429950556 908.6113918637114 525.0 915.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
indirect</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c84" name="c84" refID="G010657" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="429.3353125974796" y="852.8850603161288"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="506.0 912.0 429.3353125974796 852.8850603161288" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="427.5034149789313 855.2608025401837 431.1672102160279 850.5093180920741 423.00000000000006 848.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="506.0" y="910.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="19.0" height="19.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="10068" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_GeneExpression" refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="edgeScore" value="1.0"/>
<csml:property key="relationType" value="Type 0"/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
PMID: 17223961,17018642
Most recently it has been shown that in myeloid DCs, TLR9-induced IFN-&#946;, IL-12 and inducible macrophage type nitric oxide synthase (iNOS) is dependent on MyD88-mediated IRF1 activation</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p32" name="p14" type="cso30:c:ProcessBiological">
<csml:connector id="c85" name="c85" refID="e28" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="552.4490260061301" y="345.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:associationConnector name="default" depth="0" points="665.0 345.0 552.4490260061301 389.08246481426573" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="553.5431017007804 391.8758495665645 551.3549503114797 386.28908006196696 545.0 392.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c86" name="c86" refID="e27" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="385.0" y="407.627990121045"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="385.0 503.0 519.4745339293265 407.627990121045" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="517.7390376339347 405.1809403445425 521.2100302247184 410.0750398975475 526.0 403.00000000000006"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c148" name="c148" refID="e46" type="cso30:c:InputInhibitor">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="334.0" y="398.8935046253176"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:inhibitoryConnector name="default" depth="0" points="334.0 442.0 522.1010707258869 398.8935046253176" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<bioInhibitoryConnectorArrow size="4.0 14.0" pointsInAbsoluteCoordinate="520.537437631581 392.0703783956196 523.6647038201926 405.71663085501547 527.5636330943057 404.8231262296979 524.4363669056942 391.17687377030205"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c87" name="c87" refID="MO000000058" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="428.38022138493056" y="405.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="530.0 405.0 428.38022138493056 560.3056993928419" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="430.8905841126148 561.9482824121909 425.86985865724625 558.6631163734929 423.99999999999994 567.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="526.0" y="386.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="19.0" height="19.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="10003" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_UnknownActivation" refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="edgeScore" value="1.0"/>
<csml:property key="relationType" value="Type 0"/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
PMID: 17223961
The five TIR adaptors, MyD88, Mal, TRIF, TRAM and SARM, are differentially utiilized by TLRs leading to different signalling specificities, Table3

PMID: 17223961,16932750
Importantly, TRIF is also the sole adaptor used by TLR3, leading to activation of IRF3, IRF7 and NFKappaB 

PMID: 17223961,12566418,15767367
A52 can interact with both TRAF6 and IRAK2 and inhibit TLR-induced NFKappaB activation, especially for TLR3 , while A46 can interact with human MyD88, Mal, TRIF and TRAM and thus inhibit both TLR-induced NF&#954;B and IRF activation, although it has less of an effect on TLR3-induced NFKappaB activation than A52</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p33" name="p24" type="cso30:c:ProcessBiological">
<csml:connector id="c88" name="c88" refID="e22" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="794.0" y="440.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="859.0 440.0 794.0 440.0" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="794.0 443.0 794.0 437.0 786.0 440.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c89" name="c89" refID="MO000016573" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="287.0" y="182.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="287.0 182.0 757.9232250958339 430.2691479584731" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="759.3222946114065 427.61535736941084 756.5241555802613 432.9229385475354 765.0 434.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c90" name="c90" refID="e34" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="707.831526369483" y="447.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="765.0 447.0 707.831526369483 481.8370386185963" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="709.3926368875093 484.3988610071524 706.2704158514565 479.27521623004014 700.9999999999999 485.99999999999994"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="765.0" y="429.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="21.0" height="21.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="10005" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_Binding" refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="edgeScore" value="1.0"/>
<csml:property key="relationType" value="Type 0"/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
PMID: 17223961
Table 3

PMID: 17223961,15665823,16006187
It was shown originally to be essential for signalling to TLR-induced NFKappaB activation, but was also shown subsequently to be required for TLR-induced IRF5 activation, and for TLR7- and TLR9-induced IRF7 activation</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p34" name="p25" type="cso30:c:ProcessBiological">
<csml:connector id="c91" name="c91" refID="e34" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="420.8556362301803" y="439.5129373480347"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:associationConnector name="default" depth="0" points="683.0 490.0 420.8556362301803 439.5129373480347" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="420.2882847246673 442.4588009343523 421.4229877356933 436.5670737617171 413.0 438.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
indirect</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c92" name="c92" refID="e27" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="377.0" y="452.36019183191667"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="377.0 499.0 396.8651034789985 452.36019183191667" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="394.10503154202974 451.1846056365411 399.6251754159672 453.5357780272923 400.0 445.00000000000006"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c93" name="c93" refID="MO000000058" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="405.0" y="445.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="405.0 445.0 414.3464540844378 559.0267398301415" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="417.33642664813476 558.7816601118058 411.3564815207409 559.2718195484774 415.0 567.0000000000001"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="394.0" y="426.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="19.0" height="19.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="10003" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_UnknownActivation" refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="edgeScore" value="1.0"/>
<csml:property key="relationType" value="Type 0"/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
PMID: 17223961
Table 3 </csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p35" name="p25" type="cso30:c:ProcessBiological">
<csml:connector id="c95" name="c95" refID="MO000007700" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="599.0" y="566.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="599.0 566.0 626.9301113182073 670.272415587974" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="629.827955472717 669.4962073323018 624.0322671636975 671.0486238436463 628.9999999999999 678.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c94" name="c94" refID="e34" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="637.3433641653008" y="505.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:associationConnector name="default" depth="0" points="688.0 505.0 637.3433641653008 670.3509056491122" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="640.2117745468838 671.2296672111 634.474953783718 669.4721440871243 635.0 678.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
indirect</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c96" name="c96" refID="e30" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="641.0" y="681.7353353937364"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="641.0 687.0 698.0338665678562 681.7353353937364" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="697.7581157952051 678.7480353566824 698.3096173405073 684.7226354307902 706.0 681.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="622.0" y="678.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="19.0" height="19.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="10003" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_UnknownActivation" refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="edgeScore" value="1.0"/>
<csml:property key="relationType" value="Type 0"/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
PMID: 17223961
Table 3 </csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p36" name="p25" type="cso30:c:ProcessBiological">
<csml:connector id="c97" name="c97" refID="e34" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="492.6344663941373" y="495.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:associationConnector name="default" depth="0" points="683.0 495.0 492.6344663941373 554.609409512947" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="493.5309378267822 557.4723344107484 491.73799496149235 551.7464846151455 485.0 557.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
indirect</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c98" name="c98" refID="MO000007702" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="483.0214708392368" y="576.4074768961935"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="511.0 645.0 483.0214708392368 576.4074768961935" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="480.24366700316426 577.5405284609074 485.79927467530945 575.2744253314797 480.0 569.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c99" name="c99" refID="e31" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="485.0" y="568.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="485.0 568.0 575.0413173142156 648.6620134273181" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="577.0430622789713 646.4275074201489 573.0395723494598 650.8965194344872 581.0000000000001 654.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="466.0" y="550.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="19.0" height="19.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="10003" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_UnknownActivation" refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="edgeScore" value="1.0"/>
<csml:property key="relationType" value="Type 0"/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
PMID: 17223961
Table 3 </csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p37" name="p37" type="cso30:c:ProcessBiological">
<csml:connector id="c100" name="c100" refID="MO000066987" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="819.0" y="866.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="819.0 866.0 836.0834583345294 935.2329627241454" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="838.9960973129748 934.514259599594 833.1708193560838 935.951665848697 838.0 943.0000000000001"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c101" name="c101" refID="e35" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="847.4213478575002" y="850.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="888.0 850.0 847.4213478575002 935.768514755738" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="850.1331548240985 937.0515202023006 844.7095408909021 934.4855093091754 844.0 942.9999999999999"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c102" name="c102" refID="e36" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="805.5970433718076" y="960.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="834.0 960.0 805.5970433718076 1000.4526958037892" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="808.0522824453866 1002.176587068217 803.1418042982285 998.7288045393614 800.9999999999999 1007.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="831.0" y="943.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="17.0" height="17.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="10005" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_Binding" refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="edgeScore" value="1.0"/>
<csml:property key="relationType" value="Type 0"/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
PMID: 17223961,17038589,17038590
These helicases were thought initially to detect viral dsRNA, although recently RIG-I has been shown to recognize uncapped 5&#8242;-triphosphate viral ssRNA
</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p38" name="p37" type="cso30:c:ProcessBiological">
<csml:connector id="c103" name="c103" refID="e35" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="892.0" y="850.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="892.0 850.0 892.0 903.0" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="895.0 903.0 889.0 903.0 892.0 911.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c104" name="c104" refID="MO000103999" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="898.2635204975204" y="935.3040696849266"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="916.0 975.0 898.2635204975204 935.3040696849266" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="895.5244943656729 936.5278898714968 901.0025466293679 934.0802494983565 895.0 928.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c105" name="c105" refID="e37" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="892.0" y="928.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="892.0 928.0 898.4777518925318 1027.0170646429872" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="901.4713526514116 1026.8212216026866 895.484151133652 1027.2129076832878 898.9999999999999 1035.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="883.0" y="911.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="17.0" height="17.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="10005" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_Binding" refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="edgeScore" value="1.0"/>
<csml:property key="relationType" value="Type 0"/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
PMID: 17223961,17038589,17038590
These helicases were thought initially to detect viral dsRNA, although recently RIG-I has been shown to recognize uncapped 5&#8242;-triphosphate viral ssRNA
</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p39" name="p39" type="cso30:c:ProcessBiological">
<csml:connector id="c106" name="c106" refID="e36" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="770.2121199501515" y="1033.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="790.0 1033.0 770.2121199501515 1162.0923603252018" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="773.1774848282009 1162.5469053065085 767.2467550721021 1161.6378153438948 769.0 1170.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c107" name="c107" refID="MO000094908" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="732.0" y="1094.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="732.0 1094.0 760.895543999535 1162.6269169988955" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="763.6604501249492 1161.4627459987212 758.1306378741208 1163.79108799907 764.0000000000001 1170.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c108" name="c108" refID="e38" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="710.0" y="1180.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="758.0 1180.0 710.0 1180.0" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="710.0 1183.0 710.0 1177.0 702.0 1180.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="758.0" y="1170.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="19.0" height="19.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="10005" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_Binding" refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="edgeScore" value="1.0"/>
<csml:property key="relationType" value="Type 0"/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
PMID: 17223961,16127453,16125763,16153868,16177806
RIG-I and Mda5 each contain two caspase-recruitment domains (CARDs) and signal through the same signalling adaptor molecule, IPS-1[also called mitochondrial anti-viral signalling protein (MAVS)], virus-induced signalling adapter (VISA)and CARD adapter inducing IFN-beta (CARDIF), leading to NFKappaB, IRF3 and IRF7 activation.</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p40" name="p39" type="cso30:c:ProcessBiological">
<csml:connector id="c109" name="c109" refID="e37" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="832.9243989341309" y="1050.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="890.0 1050.0 832.9243989341309 1057.9027755321972" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="833.3358581095569 1060.8744251324963 832.5129397587048 1054.9311259318981 824.9999999999999 1059.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c110" name="c110" refID="MO000094908" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="738.0" y="1065.0471404825303"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="738.0 1081.0 798.2663581771079 1065.0471404825303" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="797.4986804961591 1062.1470247989457 799.0340358580568 1067.9472561661148 806.0 1063.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c111" name="c111" refID="e39" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="825.0" y="1066.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="825.0 1066.0 883.4698303063608 1107.3786491398862" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="885.2028368789036 1104.9298355047715 881.7368237338181 1109.8274627750009 890.0000000000001 1112.0000000000002"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="806.0" y="1050.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="19.0" height="19.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="10005" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_Binding" refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="edgeScore" value="1.0"/>
<csml:property key="relationType" value="Type 0"/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
PMID: 17223961,16127453,16125763,16153868,16177806
RIG-I and Mda5 each contain two caspase-recruitment domains (CARDs) and signal through the same signalling adaptor molecule, IPS-1[also called mitochondrial anti-viral signalling protein (MAVS)], virus-induced signalling adapter (VISA)and CARD adapter inducing IFN-beta (CARDIF), leading to NFKappaB, IRF3 and IRF7 activation.</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p41" name="p41" type="cso30:c:ProcessBiological">
<csml:connector id="c112" name="c112" refID="e38" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="360.9880535311839" y="1181.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:associationConnector name="default" depth="0" points="682.0 1181.0 360.9880535311839 1198.5629636365918" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="361.151942167462 1201.5584837107858 360.8241648949058 1195.567443562398 353.00000000000006 1199.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
indirect</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c113" name="c113" refID="e27" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="344.3245446372141" y="525.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="371.0 525.0 344.3245446372141 1182.0065857871336" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="347.32207496703904 1182.128290026089 341.3270143073892 1181.8848815481783 344.0 1190.0000000000002"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c114" name="c114" refID="MO000000058" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="345.0" y="600.9470964439134"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="345.0 1190.0 413.08149136577885 600.9470964439134" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="410.1013301993113 600.6026557060806 416.06165253224634 601.2915371817464 413.99999999999994 593.0000000000001"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="334.0" y="1190.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="19.0" height="19.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="10003" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_UnknownActivation" refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="edgeScore" value="1.0"/>
<csml:property key="relationType" value="Type 0"/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
PMID: 17223961, 16127453,16125763,16153868,16177806
RIG-I and Mda5 each contain two caspase-recruitment domains (CARDs) and signal through the same signalling adaptor molecule, IPS-1[also called mitochondrial anti-viral signalling protein (MAVS)], virus-induced signalling adapter (VISA)and CARD adapter inducing IFN-beta (CARDIF), leading to NFKappaB, IRF3 and IRF7 activation.
</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p42" name="p41" type="cso30:c:ProcessBiological">
<csml:connector id="c115" name="c115" refID="e38" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="400.9931124357964" y="1168.3318939419707"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:associationConnector name="default" depth="0" points="682.0 1180.0 400.9931124357964 1168.3318939419707" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="400.8686522075573 1171.3293111053945 401.1175726640354 1165.3344767785472 392.99999999999994 1168.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
indirect</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c116" name="c116" refID="MO000007694" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="385.9165686008044" y="447.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="467.0 447.0 385.9165686008044 1150.0526795710743" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="388.8968137616515 1150.396392796376 382.9363234399573 1149.7089663457728 385.0 1158.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c117" name="c117" refID="e29" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="386.0" y="506.8253613331332"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="386.0 1158.0 524.3375560142053 506.8253613331332" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="521.4030455142804 506.2019448384602 527.2720665141303 507.4487778278061 525.9999999999999 499.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="374.0" y="1158.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="19.0" height="19.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="10003" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_UnknownActivation" refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="edgeScore" value="1.0"/>
<csml:property key="relationType" value="Type 0"/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
PMID: 17223961, 16127453,16125763,16153868,16177806
RIG-I and Mda5 each contain two caspase-recruitment domains (CARDs) and signal through the same signalling adaptor molecule, IPS-1[also called mitochondrial anti-viral signalling protein (MAVS)], virus-induced signalling adapter (VISA)and CARD adapter inducing IFN-beta (CARDIF), leading to NFKappaB, IRF3 and IRF7 activation.
</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p43" name="p41" type="cso30:c:ProcessBiological">
<csml:connector id="c118" name="c118" refID="e38" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="468.8720966352092" y="1139.4248138706262"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:associationConnector name="default" depth="0" points="682.0 1178.0 468.8720966352092 1139.4248138706262" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="468.33779143372436 1142.3768501088296 469.40640183669393 1136.4727776324228 461.0 1138.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
indirect</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c119" name="c119" refID="MO000007702" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="454.07088471832594" y="667.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="515.0 667.0 454.07088471832594 1118.0719986175545" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="457.04388523674294 1118.4735803869269 451.0978841999089 1117.6704168481824 452.99999999999994 1126.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c120" name="c120" refID="e31" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="455.0" y="682.6686673375549"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="455.0 1126.0 586.7215046048063 682.6686673375549" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="583.8457543532232 681.8142315643572 589.5972548563894 683.5231031107525 589.0 675.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="442.0" y="1126.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="19.0" height="19.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="10003" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_UnknownActivation" refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="edgeScore" value="1.0"/>
<csml:property key="relationType" value="Type 0"/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
PMID: 17223961, 16127453,16125763,16153868,16177806
RIG-I and Mda5 each contain two caspase-recruitment domains (CARDs) and signal through the same signalling adaptor molecule, IPS-1[also called mitochondrial anti-viral signalling protein (MAVS)], virus-induced signalling adapter (VISA)and CARD adapter inducing IFN-beta (CARDIF), leading to NFKappaB, IRF3 and IRF7 activation.
</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p44" name="p41" type="cso30:c:ProcessBiological">
<csml:connector id="c121" name="c121" refID="e39" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="572.9817337573485" y="1121.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:associationConnector name="default" depth="0" points="890.0 1121.0 572.9817337573485 1142.4596980225795" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="573.1843469988812 1145.452848181585 572.7791205158159 1139.4665478635739 565.0000000000001 1143.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
indirect</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c122" name="c122" refID="e27" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="376.0" y="525.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="376.0 525.0 550.767266845946 1126.3178842326618" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="553.6480602586979 1125.4806092998915 547.8864734331942 1127.155159165432 553.0 1134.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c123" name="c123" refID="MO000000058" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="420.9369089405902" y="600.7619832359946"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="554.0 1134.0 420.9369089405902 600.7619832359946" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="418.0261652270922 601.488324088716 423.84765265408817 600.0356423832734 419.0 593.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="546.0" y="1134.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="19.0" height="19.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="10003" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_UnknownActivation" refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="edgeScore" value="1.0"/>
<csml:property key="relationType" value="Type 0"/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
PMID: 17223961, 16127453,16125763,16153868,16177806
RIG-I and Mda5 each contain two caspase-recruitment domains (CARDs) and signal through the same signalling adaptor molecule, IPS-1[also called mitochondrial anti-viral signalling protein (MAVS)], virus-induced signalling adapter (VISA)and CARD adapter inducing IFN-beta (CARDIF), leading to NFKappaB, IRF3 and IRF7 activation.
</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p45" name="p41" type="cso30:c:ProcessBiological">
<csml:connector id="c124" name="c124" refID="e39" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="688.9985352344646" y="1116.1530820140567"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:associationConnector name="default" depth="0" points="890.0 1120.0 688.9985352344646 1116.1530820140567" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="688.9411294791934 1119.152532726981 689.055940989736 1113.1536313011325 681.0 1116.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
indirect</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c125" name="c125" refID="MO000007694" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="471.0" y="447.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="471.0 447.0 666.6980172510898 1098.338350345799" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="669.5711358714152 1097.4751068149576 663.8248986307644 1099.2015938766403 669.0 1106.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c126" name="c126" refID="e29" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="532.7857377678156" y="506.7981498206047"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="670.0 1106.0 532.7857377678156 506.7981498206047" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="529.8614315850888 507.46780148353554 535.7100439505423 506.12849815767385 531.0 499.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="662.0" y="1106.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="19.0" height="19.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="10003" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_UnknownActivation" refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="edgeScore" value="1.0"/>
<csml:property key="relationType" value="Type 0"/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
PMID: 17223961, 16127453,16125763,16153868,16177806
RIG-I and Mda5 each contain two caspase-recruitment domains (CARDs) and signal through the same signalling adaptor molecule, IPS-1[also called mitochondrial anti-viral signalling protein (MAVS)], virus-induced signalling adapter (VISA)and CARD adapter inducing IFN-beta (CARDIF), leading to NFKappaB, IRF3 and IRF7 activation.
</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p46" name="p41" type="cso30:c:ProcessBiological">
<csml:connector id="c127" name="c127" refID="e39" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="855.2926937794119" y="1020.2909647972695"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:associationConnector name="default" depth="0" points="894.0 1106.0 855.2926937794119 1020.2909647972695" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="852.5585819804359 1021.525724964549 858.0268055783879 1019.05620462999 851.9999999999999 1013.0000000000001"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
indirect</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c128" name="c128" refID="MO000007702" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="526.0" y="667.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="526.0 667.0 832.4774571096888 988.2119502399622" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="834.647975769703 986.1409966560955 830.3069384496747 990.2829038238289 838.0 993.9999999999999"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c129" name="c129" refID="e31" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="604.8096138059561" y="681.3927783504167"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="840.0 994.0 604.8096138059561 681.3927783504167" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="602.4123219245499 683.1963835276503 607.2069056873625 679.5891731731832 600.0000000000001 675.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="838.0" y="994.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="19.0" height="19.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="10003" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_UnknownActivation" refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="edgeScore" value="1.0"/>
<csml:property key="relationType" value="Type 0"/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
PMID: 17223961, 16127453,16125763,16153868,16177806
RIG-I and Mda5 each contain two caspase-recruitment domains (CARDs) and signal through the same signalling adaptor molecule, IPS-1[also called mitochondrial anti-viral signalling protein (MAVS)], virus-induced signalling adapter (VISA)and CARD adapter inducing IFN-beta (CARDIF), leading to NFKappaB, IRF3 and IRF7 activation.
</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p47" name="p47" type="cso30:c:ProcessBiological">
<csml:connector id="c130" name="c130" refID="e40" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="858.2034868806554" y="651.0514107456765"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:associationConnector name="default" depth="0" points="922.0 703.0 858.2034868806554 651.0514107456765" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="856.3092078510267 653.3777183259223 860.0977659102841 648.7251031654307 852.0 646.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
indirect</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c131" name="c131" refID="MO000041125" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="557.0" y="365.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="557.0 365.0 827.2188651428185 623.4702188322611" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="829.2925330807205 621.302293260818 825.1451972049164 625.6381444037042 833.0 629.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c132" name="c132" refID="e41" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="845.0" y="648.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="845.0 648.0 856.615791964109 714.1206619495433" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="859.5705437330303 713.6015839360841 853.6610401951878 714.6397399630024 858.0 722.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="833.0" y="629.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="19.0" height="19.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="10007" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_Cleavage" refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="edgeScore" value="1.0"/>
<csml:property key="relationType" value="Type 0"/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
PMID: 17223961,15710891
This virus has a serine protease which can cleave TRIF and thus prevent TLR3 signalling to NFKappaB and IRF3</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p48" name="p47" type="cso30:c:ProcessBiological">
<csml:connector id="c133" name="c133" refID="e40" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="889.9691115068547" y="719.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:associationConnector name="default" depth="0" points="922.0 719.0 889.9691115068547 775.0540548630044" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="892.5738409332281 776.5424716780749 887.3643820804814 773.5656380479339 886.0 782.0000000000001"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
indirect</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c134" name="c134" refID="MO000094908" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="733.0" y="808.0973087114396"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="733.0 1074.0 871.3083595713391 808.0973087114396" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="868.6468688045493 806.7129435506918 873.9698503381289 809.4816738721875 875.0 801.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c135" name="c135" refID="e41" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="866.5298221281347" y="750.5894663844041"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="877.0 782.0 866.5298221281347 750.5894663844041" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="863.6837722339832 751.5381496824546 869.3758720222862 749.6407830863535 864.0 742.9999999999999"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="870.0" y="782.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="19.0" height="19.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="10007" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_Cleavage" refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="edgeScore" value="1.0"/>
<csml:property key="relationType" value="Type 0"/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
PMID: 17223961,15710891
This virus has a serine protease which can cleave TRIF and thus prevent TLR3 signalling to NFKappaB and IRF3</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p49" name="p49" type="cso30:c:ProcessBiological">
<csml:connector id="c136" name="c136" refID="e26" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="191.0" y="316.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:associationConnector name="default" depth="0" points="191.0 316.0 377.42526659151014 864.4256519834902" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="380.26564709770133 863.4601269553065 374.58488608531894 865.3911770116739 380.0 872.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
indirect</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c138" name="c138" refID="e42" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="333.0" y="801.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:associationConnector name="default" depth="0" points="333.0 801.0 372.7858663793309 865.1999207484657" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="375.33589609865624 863.6196206407149 370.2358366600056 866.7802208562167 377.0 872.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
indirect</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c137" name="c137" refID="G010262" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="395.0" y="892.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="395.0 892.0 432.4601405349522 918.3923717405345" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="434.18800113225177 915.9399244411416 430.73227993765266 920.8448190399274 439.0 923.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="372.0" y="872.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="23.0" height="23.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="10068" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_GeneExpression" refCellComponentID="cso30:i:CC_Nucleoplasm">
<csml:property key="edgeScore" value="1.0"/>
<csml:property key="relationType" value="Type 0"/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
PMID: 17223961,12163593
For example, the haemagglutinin (HA) protein of wild-type, but not vaccine, strains of measles virus activates murine and human cells via TLR2, leading to induction of proinflammatory cytokines such as IL-6 in human monocytic cells, and up-regulation of surface expression of CD150, the receptor for measles virus</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p50" name="p50" type="cso30:c:ProcessBiological">
<csml:connector id="c139" name="c139" refID="e42" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="329.0" y="801.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:associationConnector name="default" depth="0" points="329.0 801.0 348.9051366093762 945.075274505961" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="351.87690866964084 944.6647007344772 345.9333645491116 945.485848277445 350.0 953.0000000000001"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
indirect</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c140" name="c140" refID="e26" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="189.0" y="316.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:associationConnector name="default" depth="0" points="189.0 316.0 347.0511181823298 945.2410142634005" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="349.9607378335546 944.5101835817742 344.141498531105 945.9718449450269 349.0 953.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
indirect</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c141" name="c141" refID="e43" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="358.0" y="974.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="358.0 974.0 376.6065769067133 1002.3143561623898" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="379.1136933458171 1000.6668225024073 374.0994604676095 1003.9618898223723 381.0 1009.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="341.0" y="953.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="21.0" height="21.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="10068" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_GeneExpression" refCellComponentID="cso30:i:CC_Extracellular">
<csml:property key="edgeScore" value="1.0"/>
<csml:property key="relationType" value="Type 0"/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
PMID: 17223961,12163593
For example, the haemagglutinin (HA) protein of wild-type, but not vaccine, strains of measles virus activates murine and human cells via TLR2, leading to induction of proinflammatory cytokines such as IL-6 in human monocytic cells, and up-regulation of surface expression of CD150, the receptor for measles virus</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p51" name="p51" type="cso30:c:ProcessBiological">
<csml:connector id="c142" name="c142" refID="e43" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="272.945204834583" y="1023.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:associationConnector name="default" depth="0" points="367.0 1023.0 272.945204834583 1034.0652700194607" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="273.2957285772852 1037.0447218324293 272.59468109188083 1031.0858182064921 265.0 1034.9999999999998"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
indirect</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c143" name="c143" refID="e44" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="198.769862720718" y="1000.2625061574892"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="246.0 1030.0 198.769862720718 1000.2625061574892" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="197.1714229116596 1002.8012046777584 200.36830252977643 997.7238076372199 192.0 996.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="246.0" y="1026.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="19.0" height="19.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="10031" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_Translation" refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="edgeScore" value="1.0"/>
<csml:property key="relationType" value="Type 0"/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
PMID: 17223961,12163593
For example, the haemagglutinin (HA) protein of wild-type, but not vaccine, strains of measles virus activates murine and human cells via TLR2, leading to induction of proinflammatory cytokines such as IL-6 in human monocytic cells, and up-regulation of surface expression of CD150, the receptor for measles virus</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p52" name="p52" type="cso30:c:ProcessBiological">
<csml:connector id="c144" name="c144" refID="MO000016566" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="251.08194780350578" y="337.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="303.0 337.0 251.08194780350578 364.278976577819" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="252.47733158682365 366.93470700413366 249.6865640201879 361.6232461515043 244.0 368.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c145" name="c145" refID="MO000000212" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="238.4607375507422" y="387.8655098886119"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="250.0 450.0 238.4607375507422 387.8655098886119" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="235.51117134251274 388.41328647014024 241.41030375897168 387.3177333070836 237.0 380.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c146" name="c146" refID="e45" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="252.0" y="372.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="328.0 372.0 252.0 372.0" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="252.0 375.0 252.0 369.0 244.0 372.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c147" name="c147" refID="e46" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="244.0" y="378.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="244.0 378.0 308.80445555502496 430.938851016781" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="310.7023864237321 428.61552184991535 306.9065246863178 433.26218018364665 315.0 436.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="227.0" y="363.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="17.0" height="17.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="10005" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_Binding" refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="edgeScore" value="1.0"/>
<csml:property key="relationType" value="Type 0"/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
PMID: 17223961,12566418,15767367
A52 can interact with both TRAF6 and IRAK2 and inhibit TLR-induced NFKappaB activation, especially for TLR3 , while A46 can interact with human MyD88, Mal, TRIF and TRAM and thus inhibit both TLR-induced NF&#954;B and IRF activation, although it has less of an effect on TLR3-induced NFKappaB activation than A52</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p53" name="p53" type="cso30:c:ProcessBiological">
<csml:connector id="c149" name="c149" refID="e47" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="105.53215208419019" y="417.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="108.0 417.0 105.53215208419019 454.0177187371471" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="108.52550755776001 454.2172757687184 102.53879661062035 453.8181617055758 104.99999999999999 462.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c150" name="c150" refID="MO000019394" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="120.990651168656" y="468.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="175.0 468.0 120.990651168656 470.61335558861344" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="121.13564282292597 473.60984977685945 120.84565951438604 467.61686140036744 113.0 471.00000000000006"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c151" name="c151" refID="e48" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="113.0" y="479.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="113.0 479.0 172.6232628147679 524.1691384960363" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="174.4348358787543 521.7778620515743 170.81168975078154 526.5604149404984 179.0 529.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="94.0" y="462.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="19.0" height="19.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="10005" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_Binding" refCellComponentID="cso30:i:CC_Extracellular">
<csml:property key="edgeScore" value="1.0"/>
<csml:property key="relationType" value="Type 0"/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
PMID: 17223961,11062499
The first indication that viral proteins could activate TLRs was the case of the fusion (F) protein of respiratory syncitial virus (RSV)and TLR4
</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p54" name="p11" type="cso30:c:ProcessBiological">
<csml:connector id="c152" name="c152" refID="MO000016573" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="276.0" y="187.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="276.0 187.0 283.78885246047935 482.00278694065526" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="286.78780735773364 481.923606613335 280.78989756322505 482.0819672679755 284.0 490.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c153" name="c153" refID="MO000022528" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="246.0" y="313.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="246.0 313.0 280.4055267868082 482.1605067018069" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="283.3453367736306 481.56257924685997 277.46571679998584 482.7584341567538 282.0 489.99999999999994"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c154" name="c154" refID="e48" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="197.0" y="506.819639919603"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="197.0 533.0 266.5133698686404 506.819639919603" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="265.4560048987893 504.01215362034316 267.5707348384915 509.6271262188628 274.0 504.00000000000006"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c155" name="c155" refID="e49" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="198.65685424949237" y="509.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="275.0 509.0 198.65685424949237 585.3431457505076" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="200.778174593052 587.4644660940672 196.5355339059327 583.2218254069479 192.99999999999997 591.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="274.0" y="490.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="19.0" height="19.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="10005" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_Binding" refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="edgeScore" value="1.0"/>
<csml:property key="relationType" value="Type 0"/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
PMID: 17223961
The five TIR adaptors, MyD88, Mal, TRIF, TRAM and SARM, are differentially utiilized by TLRs leading to different signalling specificities, Table3

PMID: 17223961
TRAM is uniquely utilized by TLR4 for both NF-KappaB and IRF3 activation, while Mal has been shown to have a role in NF-KappaB activation for both TLR4 and TLR2.</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p55" name="p11" type="cso30:c:ProcessBiological">
<csml:connector id="c156" name="c156" refID="MO000041132" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="267.1842634229863" y="352.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="369.0 352.0 267.1842634229863 586.6610309679744" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="269.9363768099959 587.8551297515943 264.4321500359767 585.4669321843545 264.0 594.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c157" name="c157" refID="MO000041125" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="275.06770299741044" y="364.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="539.0 364.0 275.06770299741044 590.7862700170399" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="277.0228517410205 593.0616586410688 273.11255425380045 588.510881393011 269.00000000000006 595.9999999999999"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c158" name="c158" refID="e48" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="197.0" y="545.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="197.0 545.0 244.1808507799243 589.5102365848343" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="246.23951206061145 587.3280556273058 242.12218949923712 591.6924175423626 250.0 595.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c159" name="c159" refID="e63" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="198.24282653774407" y="613.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="252.0 613.0 198.24282653774407 674.9574202615831" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="200.50879393965042 676.9234802132372 195.97685913583774 672.9913603099292 193.0 681.0000000000001"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="250.0" y="594.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="19.0" height="19.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="10005" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_Binding" refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="edgeScore" value="1.0"/>
<csml:property key="relationType" value="Type 0"/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
PMID: 17223961
The five TIR adaptors, MyD88, Mal, TRIF, TRAM and SARM, are differentially utiilized by TLRs leading to different signalling specificities, Table3

PMID: 17223961
TRAM is uniquely utilized by TLR4 for both NF-KappaB and IRF3 activation, while Mal has been shown to have a role in NF-KappaB activation for both TLR4 and TLR2.</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p56" name="p56" type="cso30:c:ProcessBiological">
<csml:connector id="c160" name="c160" refID="e63" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="193.0" y="693.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:associationConnector name="default" depth="0" points="193.0 693.0 294.03345615193984 702.2691244176092" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="294.3075344953364 699.2816704745867 293.7593778085433 705.2565783606318 302.0 703.0000000000001"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
indirect</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c161" name="c161" refID="e27" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="317.39391429035845" y="525.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="368.0 525.0 317.39391429035845 686.3665751873476" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="320.2564485951031 687.2642930462321 314.5313799856138 685.4688573284633 315.0 694.0000000000001"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c162" name="c162" refID="MO000000058" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="320.0" y="599.1208608422172"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="320.0 694.0 399.84878047932216 599.1208608422172" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="397.5534576634907 597.189153521963 402.14410329515357 601.0525681624714 404.99999999999994 593.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="302.0" y="694.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="19.0" height="19.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="10003" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_UnknownActivation" refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="edgeScore" value="1.0"/>
<csml:property key="relationType" value="Type 0"/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
PMID: 17223961
Table 3
</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p57" name="p56" type="cso30:c:ProcessBiological">
<csml:connector id="c163" name="c163" refID="e49" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="193.0" y="536.745877408417"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:associationConnector name="default" depth="0" points="193.0 595.0 302.93116682605176 536.745877408417" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="301.52646279789536 534.0950649681864 304.3358708542081 539.3966898486476 310.0 533.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
indirect</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c164" name="c164" refID="e27" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="336.6626102817692" y="516.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="359.0 516.0 336.6626102817692 522.7012169154692" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="337.52465393846825 525.5746957711327 335.8005666250702 519.8277380598058 329.0 525.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c165" name="c165" refID="MO000000058" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="329.0" y="533.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="329.0 533.0 395.962347891391 569.1958637250762" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="397.3888989944874 566.5567441843477 394.5357967882946 571.8349832658045 403.0 572.9999999999999"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="310.0" y="518.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="19.0" height="19.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="10003" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_UnknownActivation" refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="edgeScore" value="1.0"/>
<csml:property key="relationType" value="Type 0"/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
PMID: 17223961
Table 3
</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p58" name="p56" type="cso30:c:ProcessBiological">
<csml:connector id="c166" name="c166" refID="e49" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="193.0" y="602.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:associationConnector name="default" depth="0" points="193.0 602.0 362.19677764732387 640.2365599202992" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="362.8580676772117 637.3103515380457 361.53548761743605 643.1627683025528 370.00000000000006 642.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
indirect</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c167" name="c167" refID="MO000007700" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="396.4121425450471" y="560.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="586.0 560.0 396.4121425450471 636.9899928751078" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="397.5408952168817 639.7695463295005 395.2833898732125 634.2104394207151 389.0 640.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c168" name="c168" refID="e30" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="389.0" y="645.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector depth="0" points="389.0 645.0 698.0456217461401 678.1468490200907" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="698.3655533636061 675.1639571748932 697.7256901286742 681.1297408652881 706.0 678.9999999999999"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="370.0" y="634.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="19.0" height="19.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="10003" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_UnknownActivation" refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="edgeScore" value="1.0"/>
<csml:property key="relationType" value="Type 0"/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
PMID: 17223961
Table 3
</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p59" name="p56" type="cso30:c:ProcessBiological">
<csml:connector id="c169" name="c169" refID="e63" type="cso30:c:InputAssociation">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="193.0" y="612.7899007857226"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:associationConnector name="default" depth="0" points="193.0 687.0 330.95467161628505 612.7899007857226" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<associationConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="329.5334588216391 610.1479026418294 332.375884410931 615.4318989296156 338.0 609.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text">
indirect</csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c170" name="c170" refID="MO000007694" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="359.64990554975276" y="447.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="460.0 447.0 359.64990554975276 587.4901322303461" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="362.09110596337297 589.2338468115034 357.20870513613255 585.7464176491889 355.0 594.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c171" name="c171" refID="e29" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="357.0" y="500.31963755426915"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="357.0 598.0 509.2664473418746 500.31963755426915" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="507.64658325902366 497.79455530747214 510.88631142472553 502.8447198010662 516.0 496.00000000000006"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="338.0" y="594.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="19.0" height="19.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="10003" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_UnknownActivation" refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="edgeScore" value="1.0"/>
<csml:property key="relationType" value="Type 0"/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
PMID: 17223961
Table 3
</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p60" name="p60" type="cso30:c:ProcessBiological">
<csml:connector id="c172" name="c172" refID="e63" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="193.0" y="703.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="193.0 703.0 266.78823813401794 788.9306064345525" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="269.06426072106075 786.9761957348093 264.51221554697514 790.8850171342958 272.0 795.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c173" name="c173" refID="e64" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="255.0" y="819.3677380085485"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="255.0 864.0 273.8828800733064 819.3677380085485" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="271.11997832010076 818.1988180360383 276.6457818265121 820.5366579810585 277.0 812.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c174" name="c174" refID="e65" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="200.15541752799933" y="764.5777087639997"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="271.0 800.0 200.15541752799933 764.5777087639997" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="198.81377674149945 767.2609903369994 201.4970583144992 761.8944271909999 193.0 761.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="271.0" y="795.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="17.0" height="17.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="10005" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_Binding" refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="edgeScore" value="1.0"/>
<csml:property key="relationType" value="Type 0"/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
PMID: 17223961, 12566418, 15767367
A52 can interact with both TRAF6 and IRAK2 and inhibit TLR-induced NFKappaB activation, especially for TLR3 , while A46 can interact with human MyD88, Mal, TRIF and TRAM and thus inhibit both TLR-induced NF&#954;B and IRF activation, although it has less of an effect on TLR3-induced NFKappaB activation than A52
</csml:comment>
</csml:comments>
</csml:process>
<csml:process id="p61" name="p60" type="cso30:c:ProcessBiological">
<csml:connector id="c177" name="c177" refID="e64" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="249.0" y="687.9942170515637"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="249.0 864.0 255.69587217738615 687.9942170515637" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="252.69804078304975 687.8801691180836 258.69370357172255 688.108264985044 255.99999999999997 680.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c178" name="c178" refID="e49" type="cso30:c:InputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="193.0" y="609.0"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="193.0 609.0 241.34314575050763 657.3431457505076" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="243.46446609406726 655.2218254069479 239.22182540694797 659.4644660940672 247.0 662.9999999999999"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:connector id="c179" name="c179" refID="e66" type="cso30:c:OutputProcess">
<csml:connectorSimulationProperty>
<csml:connectorFiring connectorFiringStyle="csml-connectorFiringStyle:threshold" value="0"/>
<csml:connectorKinetic>
<csml:parameter key="stoichiometry" value="1"/>
</csml:connectorKinetic>
</csml:connectorSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="200.70814327703954" y="657.1411509102887"/>
<csml:shape shapeID="default" visible="true">
<csml:toolSpecificGraphics>
<fig:figure xmlns:fig="http://www.csml.org/csml/cigraphics">
<fig:processConnector name="default" depth="0" points="247.0 670.0 200.70814327703954 657.1411509102887" visible="true"/>
</fig:figure>
<targetArrow xmlns="http://www.csml.org/csml/cigraphics">
<processConnectorArrow size="8.0 6.0" points="0.0 0.0 0.0 6.0 8.0 3.0" pointsInAbsoluteCoordinate="199.90521168568125 660.0317046391785 201.51107486839783 654.2505971813989 193.0 655.0"/>
</targetArrow>
</csml:toolSpecificGraphics>
</csml:shape>
</csml:viewProperty>
<csml:comments>
<csml:comment type="text"></csml:comment>
</csml:comments>
</csml:connector>
<csml:processSimulationProperty>
<csml:priority value="0"/>
<csml:firing firingStyle="csml-firingStyle:and" firingOnce="false" type="csml-variable:Boolean" value="true"/>
<csml:delay delayStyle="nodelay" value="0.0"/>
<csml:processKinetic calcStyle="csml-calcStyle:speed" kineticStyle="csml-kineticStyle:mass" fast="false">
<csml:parameter key="coefficient1" value="0.1"/>
<csml:parameter key="coefficient2" value="1.0"/>
</csml:processKinetic>
</csml:processSimulationProperty>
<csml:viewProperty>
<csml:position positionID="default" position="auto" x="247.0" y="663.0"/>
<csml:shape shapeID="default" visible="true">
<csml:image width="17.0" height="17.0" filePath="" fileType="resourceFile" fileFormat="svg" resourceID="10005" outlineColor="0 0 0 0"></csml:image>
<csml:toolSpecificGraphics/>
</csml:shape>
</csml:viewProperty>
<csml:biologicalProperty refBiologicalEventID="cso30:i:ME_Binding" refCellComponentID="cso30:i:CC_Cytosol">
<csml:property key="edgeScore" value="1.0"/>
<csml:property key="relationType" value="Type 0"/>
</csml:biologicalProperty>
<csml:comments>
<csml:comment type="text">
PMID: 17223961, 12566418, 15767367
A52 can interact with both TRAF6 and IRAK2 and inhibit TLR-induced NFKappaB activation, especially for TLR3 , while A46 can interact with human MyD88, Mal, TRIF and TRAM and thus inhibit both TLR-induced NF&#954;B and IRF activation, although it has less of an effect on TLR3-induced NFKappaB activation than A52
</csml:comment>
</csml:comments>
</csml:process>
</csml:processSet>
<csml:factSet>
<csml:fact id="g2" name="g1" type="cso30:c:FactViewGroup">
<csml:participant id="participant-e13" name="participant-e13" refID="e13" type="csml-element:participant"/>
<csml:participant id="participant-e14" name="participant-e14" refID="e14" type="csml-element:participant"/>
<csml:participant id="participant-e15" name="participant-e15" refID="e15" type="csml-element:participant"/>
</csml:fact>
<csml:fact id="g1" name="g1" type="cso30:c:FactViewGroup">
<csml:participant id="participant-e3" name="participant-e3" refID="e3" type="csml-element:participant"/>
<csml:participant id="participant-e4" name="participant-e4" refID="e4" type="csml-element:participant"/>
<csml:participant id="participant-e2" name="participant-e2" refID="e2" type="csml-element:participant"/>
<csml:participant id="participant-e1" name="participant-e1" refID="e1" type="csml-element:participant"/>
</csml:fact>
<csml:fact id="g12" name="g2" type="cso30:c:FactViewGroup">
<csml:participant id="participant-e54" name="participant-e54" refID="e54" type="csml-element:participant"/>
<csml:participant id="participant-g13" name="participant-g13" refID="g13" type="csml-element:participant"/>
<csml:participant id="participant-e56" name="participant-e56" refID="e56" type="csml-element:participant"/>
<csml:participant id="participant-e58" name="participant-e58" refID="e58" type="csml-element:participant"/>
<csml:participant id="participant-e55" name="participant-e55" refID="e55" type="csml-element:participant"/>
<csml:participant id="participant-e53" name="participant-e53" refID="e53" type="csml-element:participant"/>
<csml:participant id="participant-e52" name="participant-e52" refID="e52" type="csml-element:participant"/>
<csml:participant id="participant-e57" name="participant-e57" refID="e57" type="csml-element:participant"/>
<csml:participant id="participant-e59" name="participant-e59" refID="e59" type="csml-element:participant"/>
<csml:participant id="participant-e51" name="participant-e51" refID="e51" type="csml-element:participant"/>
<csml:participant id="participant-e50" name="participant-e50" refID="e50" type="csml-element:participant"/>
</csml:fact>
<csml:fact id="g13" name="g2" type="cso30:c:FactViewGroup">
<csml:participant id="participant-e60" name="participant-e60" refID="e60" type="csml-element:participant"/>
<csml:participant id="participant-e62" name="participant-e62" refID="e62" type="csml-element:participant"/>
<csml:participant id="participant-e61" name="participant-e61" refID="e61" type="csml-element:participant"/>
</csml:fact>
<csml:fact id="g14" name="g1" type="cso30:c:FactViewGroup"/>
</csml:factSet>
<csml:modelSimulationProperty>
<csml:parameter key="enhancedFiring" value="true"/>
<csml:parameter key="discreteWeakFiring" value="false"/>
<csml:parameter key="continousWeakFiring" value="false"/>
<csml:parameter key="samplingInterval" value="0.1"/>
<csml:parameter key="plotUpdateInterval" value="1.0"/>
<csml:parameter key="logUpdateInterval" value="1.0"/>
<csml:parameter key="simulationTime" value="1000.0"/>
<csml:parameter key="firingAccuracy" value="1.0E-10"/>
</csml:modelSimulationProperty>
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:model>
<csml:subModelSet/>
<csml:viewSet>
<csml:view name="Default View" viewID="default" refModelID="undef" refShapeID="default" refPositionID="default" refAnimationID="default"/>
</csml:viewSet>
<csml:references>
<csml:unificationXref unificationXrefID="ref0" name="IPR000719" xlink:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR000719" db="INTERPRO">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref1" name="IPR008271" xlink:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR008271" db="INTERPRO">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref2" name="IPR001159" xlink:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR001159" db="INTERPRO">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref3" name="IPR001245" xlink:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR001245" db="INTERPRO">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref4" name="MO000008179" xlink:href="http://www.biobase.de/cgi-bin/biobase/transpath/8.4/bin/get.cgi?MO000008179" db="TRANSPATH">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref5" name="MO000022225" xlink:href="http://www.biobase.de/cgi-bin/biobase/transpath/8.4/bin/get.cgi?MO000022225" db="TRANSPATH">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref6" name="MO000022224" xlink:href="http://www.biobase.de/cgi-bin/biobase/transpath/8.4/bin/get.cgi?MO000022224" db="TRANSPATH">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref7" name="IPR000157" xlink:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR000157" db="INTERPRO">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref8" name="IPR003591" xlink:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR003591" db="INTERPRO">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref9" name="IPR000483" xlink:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR000483" db="INTERPRO">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref10" name="IPR001611" xlink:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR001611" db="INTERPRO">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref11" name="IPR000372" xlink:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR000372" db="INTERPRO">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref12" name="MO000019398" xlink:href="http://www.biobase.de/cgi-bin/biobase/transpath/8.4/bin/get.cgi?MO000019398" db="TRANSPATH">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref13" name="IPR000157" xlink:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR000157" db="INTERPRO">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref14" name="IPR002086" xlink:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR002086" db="INTERPRO">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref15" name="IPR003591" xlink:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR003591" db="INTERPRO">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref16" name="IPR000483" xlink:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR000483" db="INTERPRO">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref17" name="IPR004075" xlink:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR004075" db="INTERPRO">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref18" name="IPR001611" xlink:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR001611" db="INTERPRO">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref19" name="MO000019397" xlink:href="http://www.biobase.de/cgi-bin/biobase/transpath/8.4/bin/get.cgi?MO000019397" db="TRANSPATH">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref20" name="MO000042012" xlink:href="http://www.biobase.de/cgi-bin/biobase/transpath/8.4/bin/get.cgi?MO000042012" db="TRANSPATH">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref21" name="MO000042126" xlink:href="http://www.biobase.de/cgi-bin/biobase/transpath/8.4/bin/get.cgi?MO000042126" db="TRANSPATH">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref22" name="MO000042007" xlink:href="http://www.biobase.de/cgi-bin/biobase/transpath/8.4/bin/get.cgi?MO000042007" db="TRANSPATH">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref23" name="MO000041125" xlink:href="http://www.biobase.de/cgi-bin/biobase/transpath/8.4/bin/get.cgi?MO000041125" db="TRANSPATH">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref24" name="IPR000157" xlink:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR000157" db="INTERPRO">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref25" name="IPR004075" xlink:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR004075" db="INTERPRO">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref26" name="IPR000488" xlink:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR000488" db="INTERPRO">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref27" name="MO000016573" xlink:href="http://www.biobase.de/cgi-bin/biobase/transpath/8.4/bin/get.cgi?MO000016573" db="TRANSPATH">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref28" name="IPR000157" xlink:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR000157" db="INTERPRO">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref29" name="MO000022528" xlink:href="http://www.biobase.de/cgi-bin/biobase/transpath/8.4/bin/get.cgi?MO000022528" db="TRANSPATH">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref30" name="MO000000058" xlink:href="http://www.biobase.de/cgi-bin/biobase/transpath/8.4/bin/get.cgi?MO000000058" db="TRANSPATH">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref31" name="MO000000058" xlink:href="http://www.biobase.de/cgi-bin/biobase/transpath/8.4/bin/get.cgi?MO000000058" db="TRANSPATH">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref32" name="IPR008984" xlink:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR008984" db="INTERPRO">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref33" name="IPR001346" xlink:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR001346" db="INTERPRO">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref34" name="MO000007694" xlink:href="http://www.biobase.de/cgi-bin/biobase/transpath/8.4/bin/get.cgi?MO000007694" db="TRANSPATH">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref35" name="IPR008984" xlink:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR008984" db="INTERPRO">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref36" name="IPR001346" xlink:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR001346" db="INTERPRO">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref37" name="MO000007694" xlink:href="http://www.biobase.de/cgi-bin/biobase/transpath/8.4/bin/get.cgi?MO000007694" db="TRANSPATH">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref38" name="IPR008984" xlink:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR008984" db="INTERPRO">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref39" name="IPR001346" xlink:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR001346" db="INTERPRO">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref40" name="MO000007700" xlink:href="http://www.biobase.de/cgi-bin/biobase/transpath/8.4/bin/get.cgi?MO000007700" db="TRANSPATH">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref41" name="IPR008984" xlink:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR008984" db="INTERPRO">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref42" name="IPR001346" xlink:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR001346" db="INTERPRO">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref43" name="MO000007700" xlink:href="http://www.biobase.de/cgi-bin/biobase/transpath/8.4/bin/get.cgi?MO000007700" db="TRANSPATH">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref44" name="MO000007702" xlink:href="http://www.biobase.de/cgi-bin/biobase/transpath/8.4/bin/get.cgi?MO000007702" db="TRANSPATH">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref45" name="MO000007702" xlink:href="http://www.biobase.de/cgi-bin/biobase/transpath/8.4/bin/get.cgi?MO000007702" db="TRANSPATH">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref46" name="G010262" xlink:href="http://www.biobase.de/cgi-bin/biobase/transfac/10.4/bin/start.cgi?ac=TransFac:G010262" db="TRANSFAC">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref47" name="G010262" xlink:href="http://www.biobase.de/cgi-bin/biobase/transfac/10.4/bin/start.cgi?ac=TransFac:G010262" db="TRANSFAC">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref48" name="G010228" xlink:href="http://www.biobase.de/cgi-bin/biobase/transfac/10.4/bin/start.cgi?ac=TransFac:G010228" db="TRANSFAC">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref49" name="G010228" xlink:href="http://www.biobase.de/cgi-bin/biobase/transfac/10.4/bin/start.cgi?ac=TransFac:G010228" db="TRANSFAC">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref50" name="G010657" xlink:href="http://www.biobase.de/cgi-bin/biobase/transfac/10.4/bin/start.cgi?ac=TransFac:G010657" db="TRANSFAC">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref51" name="G010657" xlink:href="http://www.biobase.de/cgi-bin/biobase/transfac/10.4/bin/start.cgi?ac=TransFac:G010657" db="TRANSFAC">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref52" name="G010329" xlink:href="http://www.biobase.de/cgi-bin/biobase/transfac/10.4/bin/start.cgi?ac=TransFac:G010329" db="TRANSFAC">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref53" name="G010329" xlink:href="http://www.biobase.de/cgi-bin/biobase/transfac/10.4/bin/start.cgi?ac=TransFac:G010329" db="TRANSFAC">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref54" name="G010522" xlink:href="http://www.biobase.de/cgi-bin/biobase/transfac/10.4/bin/start.cgi?ac=TransFac:G010522" db="TRANSFAC">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref55" name="G010522" xlink:href="http://www.biobase.de/cgi-bin/biobase/transfac/10.4/bin/start.cgi?ac=TransFac:G010522" db="TRANSFAC">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref56" name="IPR001346" xlink:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR001346" db="INTERPRO">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref57" name="MO000007685" xlink:href="http://www.biobase.de/cgi-bin/biobase/transpath/8.4/bin/get.cgi?MO000007685" db="TRANSPATH">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref58" name="IPR001346" xlink:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR001346" db="INTERPRO">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref59" name="MO000007685" xlink:href="http://www.biobase.de/cgi-bin/biobase/transpath/8.4/bin/get.cgi?MO000007685" db="TRANSPATH">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref60" name="G010514" xlink:href="http://www.biobase.de/cgi-bin/biobase/transfac/10.4/bin/start.cgi?ac=TransFac:G010514" db="TRANSFAC">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref61" name="G010514" xlink:href="http://www.biobase.de/cgi-bin/biobase/transfac/10.4/bin/start.cgi?ac=TransFac:G010514" db="TRANSFAC">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref62" name="MO000066987" xlink:href="http://www.biobase.de/cgi-bin/biobase/transpath/8.4/bin/get.cgi?MO000066987" db="TRANSPATH">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref63" name="MO000103999" xlink:href="http://www.biobase.de/cgi-bin/biobase/transpath/8.4/bin/get.cgi?MO000103999" db="TRANSPATH">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref64" name="MO000094908" xlink:href="http://www.biobase.de/cgi-bin/biobase/transpath/8.4/bin/get.cgi?MO000094908" db="TRANSPATH">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref65" name="IPR001841" xlink:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR001841" db="INTERPRO">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref66" name="IPR002083" xlink:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR002083" db="INTERPRO">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref67" name="IPR000504" xlink:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR000504" db="INTERPRO">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref68" name="IPR001293" xlink:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR001293" db="INTERPRO">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref69" name="IPR008974" xlink:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR008974" db="INTERPRO">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref70" name="MO000000212" xlink:href="http://www.biobase.de/cgi-bin/biobase/transpath/8.4/bin/get.cgi?MO000000212" db="TRANSPATH">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref71" name="IPR000719" xlink:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR000719" db="INTERPRO">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref72" name="IPR000488" xlink:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR000488" db="INTERPRO">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref73" name="MO000016566" xlink:href="http://www.biobase.de/cgi-bin/biobase/transpath/8.4/bin/get.cgi?MO000016566" db="TRANSPATH">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref74" name="IPR000157" xlink:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR000157" db="INTERPRO">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref75" name="IPR003591" xlink:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR003591" db="INTERPRO">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref76" name="IPR000887" xlink:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR000887" db="INTERPRO">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref77" name="IPR000483" xlink:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR000483" db="INTERPRO">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref78" name="IPR001611" xlink:href="http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR001611" db="INTERPRO">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref79" name="MO000019394" xlink:href="http://www.biobase.de/cgi-bin/biobase/transpath/8.4/bin/get.cgi?MO000019394" db="TRANSPATH">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
<csml:unificationXref unificationXrefID="ref80" name="MO000041132" xlink:href="http://www.biobase.de/cgi-bin/biobase/transpath/8.4/bin/get.cgi?MO000041132" db="TRANSPATH">
<csml:comments>
<csml:comment type="text">
</csml:comment>
</csml:comments>
</csml:unificationXref>
</csml:references>
</csml:project>
