Entity
LPS
--
MO000016882
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m155666
10
infinite
0
--
--
e1
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane
--
--
--
csml-variable:Double
m1
0
infinite
0
--
--
e10
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytosol
--
--
--
csml-variable:Double
m10
0
infinite
0
--
MARCO
--
e11
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m11
0
infinite
0
--
fascin
--
e12
cso30:c:mRNA
cso30:i:CC_Cytosol
--
csml-variable:Double
m12
0
infinite
0
--
fascin
--
e13
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m13
0
infinite
0
--
marco
--
e14
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m14
0
infinite
0
--
profilin:TLR11
--
e15
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m15
0
infinite
0
--
TLR11
--
e16
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m16
0
infinite
0
--
profilin
--
e17
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m17
0
infinite
0
--
--
e18
cso30:c:EntityBiologicalCompartment
cso30:i:CC_EndosomeMembrane
--
--
--
csml-variable:Double
m18
0
infinite
0
--
--
e19
cso30:c:EntityBiologicalCompartment
cso30:i:CC_EndosomeLumen
--
--
--
csml-variable:Double
m19
0
infinite
0
--
--
e2
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m2
0
infinite
0
--
--
e20
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Endosome
--
--
--
csml-variable:Double
m20
0
infinite
0
--
TLR9
--
e21
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m21
0
infinite
0
--
CpG-A:TLR9
--
e22
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m22
0
infinite
0
--
CpG-A
--
e23
cso30:c:Dna
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m23
0
infinite
0
--
type I interferon
--
e24
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m24
0
infinite
0
--
type I interferon
--
e25
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m25
0
infinite
0
--
IRF-7
--
e26
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m26
0
infinite
0
--
MYD88
--
e27
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m27
0
infinite
0
--
CpG-A:TLR9:MYD88:IRF-7
--
e28
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m28
0
infinite
0
--
MHC class II beta chain {ub}n
--
e29
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m29
0
infinite
0
--
--
e3
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
--
csml-variable:Double
m3
0
infinite
0
--
MHC class II beta chain
--
e30
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m30
0
infinite
0
--
cMIR
--
e31
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m31
0
infinite
0
--
MHC class II beta chain
--
e32
cso30:c:mRNA
cso30:i:CC_Cytosol
--
csml-variable:Double
m32
0
infinite
0
--
MHC class II beta chain
--
e33
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
csml-variable:Double
m33
0
infinite
0
--
MHC class I
--
e34
cso30:c:mRNA
cso30:i:CC_Nucleolus
--
csml-variable:Double
m34
0
infinite
0
--
MHC class I
--
e35
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m35
0
infinite
0
--
--
e4
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m4
0
infinite
0
--
csml-variable:Double
m5
0
infinite
0
--
--
e50
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelopeLumen
--
--
--
csml-variable:Double
m50
0
infinite
0
--
--
e51
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearPore
--
--
--
csml-variable:Double
m51
0
infinite
0
--
--
e52
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearInnerMembrane
--
--
--
csml-variable:Double
m52
0
infinite
0
--
--
e53
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearLumen
--
--
--
csml-variable:Double
m53
0
infinite
0
--
--
e54
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearOuterMembrane
--
--
--
csml-variable:Double
m54
0
infinite
0
--
--
e55
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleus
--
--
--
csml-variable:Double
m55
0
infinite
0
--
--
e56
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleoplasm
--
--
--
csml-variable:Double
m56
0
infinite
0
--
--
e57
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearBody
--
--
--
csml-variable:Double
m57
0
infinite
0
--
--
e58
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleolus
--
--
--
csml-variable:Double
m58
0
infinite
0
--
--
e59
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelope
--
--
--
csml-variable:Double
m59
0
infinite
0
--
TLR ligand:TLR
--
e6
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
csml-variable:Double
m6
0
infinite
0
--
--
e60
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Chromatin
--
--
--
csml-variable:Double
m60
0
infinite
0
--
--
e61
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearChromosome
--
--
--
csml-variable:Double
m61
0
infinite
0
--
--
e62
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearCentromere
--
--
--
csml-variable:Double
m62
0
infinite
0
--
--
e7
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell
--
--
--
csml-variable:Double
m7
0
infinite
0
--
--
e8
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell_WithoutCellWall_
--
--
--
csml-variable:Double
m8
0
infinite
0
--
--
e9
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytoplasm
--
--
--
csml-variable:Double
m9
0
infinite
0
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
m155666*0.1
nodelay
--
0
PMID: 17142025, 16849464 In human DCs, LPS-induced prostaglandin E2 (PGE2) production appeared to be crucial because podosome loss was blocked by indomethacin and triggered by addition of PGE2
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c24 : 1
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1
m22*m27*m26*0.1
nodelay
--
0
PMID: 17142025, 15815647 Nonetheless, this compartmental specificity seems to control the immunological outcome, partly at least because a complex of the transcription factor IRF7 and the signalling adaptor MyD88, both of which are known to be needed for Type I interferon production, is recruited to early endosomes in pDC
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c30 : 1
stoichiometry:c29 : 1
m30*m31*0.1
nodelay
--
0
PMID: 17142025, 16785530 A clue as to how MHC class II traffic might be regulated in DCs came from a demonstration that transgenic or in vitro overexpression of the E3-ligase cMIR leads to down-regulation of MHC class II molecules through ubiquitination of lysine 225 in the ¦Â chain PMID: 17142025, 17174123, 17051151 Two new studies show that this residue is oligo-ubiquitinated in immature DCs but not in mature DCs
p12
p12
cso30:i:ME_GeneExpression
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c31 : 1
m155666*0.1
nodelay
--
0
PMID: 17142025, 9285592, 9285591 DC maturation, driven typically by LPS signalling, results in dramatically increased levels of cell surface MHC class I and class II molecules in human and murine DCs
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c33 : 1
stoichiometry:c39 : 1
stoichiometry:c32 : 1
m32*m155666*0.1
nodelay
--
0
PMID: 17142025, 9285592, 9285591 DC maturation, driven typically by LPS signalling, results in dramatically increased levels of cell surface MHC class I and class II molecules in human and murine DCs
p14
p14
cso30:i:ME_GeneExpression
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c36 : 1
m155666*0.1
nodelay
--
0
PMID: 17142025, 9285592, 9285591 DC maturation, driven typically by LPS signalling, results in dramatically increased levels of cell surface MHC class I and class II molecules in human and murine DCs
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c40 : 1
stoichiometry:c34 : 1
m34*m155666*0.1
nodelay
--
0
PMID: 17142025, 9285592, 9285591 DC maturation, driven typically by LPS signalling, results in dramatically increased levels of cell surface MHC class I and class II molecules in human and murine DCs
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c6 : 1
m6*0.1
nodelay
--
0
PMID: 17142025, 10998139, 11123310, 12842997 These include the scavenger receptor MARCO and the actin cross-linking protein fascin , which are expressed only in mature DCs and are in part responsible for their distinctive morphology and ability to interact with T cells.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c11 : 1
stoichiometry:c5 : 1
m6*0.1
nodelay
--
0
PMID: 17142025, 10998139, 11123310, 12842997 These include the scavenger receptor MARCO and the actin cross-linking protein fascin , which are expressed only in mature DCs and are in part responsible for their distinctive morphology and ability to interact with T cells.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c3 : 1
stoichiometry:c12 : 1
stoichiometry:c4 : 1
m12*m6*0.1
nodelay
--
0
PMID: 17142025, 10998139, 11123310, 12842997 These include the scavenger receptor MARCO and the actin cross-linking protein fascin , which are expressed only in mature DCs and are in part responsible for their distinctive morphology and ability to interact with T cells.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c9 : 1
stoichiometry:c8 : 1
m11*m6*0.1
nodelay
--
0
PMID: 17142025, 10998139, 11123310, 12842997 These include the scavenger receptor MARCO and the actin cross-linking protein fascin , which are expressed only in mature DCs and are in part responsible for their distinctive morphology and ability to interact with T cells.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1
m17*m16*0.1
nodelay
--
0
PMID: 17142025,15860593 A recent study on the Toxoplasma gondii parasite suggests that it can. T. gondii profilin, a ligand for TLR11 is immunodominant in the CD4 T-cell response
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1
m23*m21*0.1
nodelay
--
0
PMID: 17142025, 11861616 Upon recognition of different types of CpG-containing DNA sequences, TLR9 in pDCs either triggers production of type I interferon (CpG-A) or drives pDC maturation (CpG-B), as measured by elevated expression of costimulatory molecules
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c20 : 1
stoichiometry:c19 : 1
m28*0.1
nodelay
--
0
PMID: 17142025, 11861616 Upon recognition of different types of CpG-containing DNA sequences, TLR9 in pDCs either triggers production of type I interferon (CpG-A) or drives pDC maturation (CpG-B), as measured by elevated expression of costimulatory molecules PMID: 17142025, 15815647 Nonetheless, this compartmental specificity seems to control the immunological outcome, partly at least because a complex of the transcription factor IRF7 and the signalling adaptor MyD88, both of which are known to be needed for Type I interferon production, is recruited to early endosomes in pDC
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c21 : 1
m24*m28*0.1
nodelay
--
0
PMID: 17142025, 11861616 Upon recognition of different types of CpG-containing DNA sequences, TLR9 in pDCs either triggers production of type I interferon (CpG-A) or drives pDC maturation (CpG-B), as measured by elevated expression of costimulatory molecules PMID: 17142025, 15815647 Nonetheless, this compartmental specificity seems to control the immunological outcome, partly at least because a complex of the transcription factor IRF7 and the signalling adaptor MyD88, both of which are known to be needed for Type I interferon production, is recruited to early endosomes in pDC
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--