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PMID:17114416,9596579
As shown for DUSP6, binding to the substrate ERK2 MAPK then strongly increases the catalytic activity
PMID: 17114416
In contrast to DUSP6, the catalytic activity of DUSP10 is not increased by binding to p38 or JNK
PMID: 17114416
In contrast to DUSP6, the catalytic activity of DUSP10 is not increased by binding to p38 or JNK
indirect
PMID: 17114416,15980098,12435740
Kovanen et al. analyzed T cell transcriptional responses to cytokine signaling through the common {gamma}-chain and identified DUSP5/VH3 and DUSP6/MKP-3 as up-regulated by IL-2, IL-7, and IL-15.
indirect
PMID: 17114416,15980098,12435740
Kovanen et al. analyzed T cell transcriptional responses to cytokine signaling through the common {gamma}-chain and identified DUSP5/VH3 and DUSP6/MKP-3 as up-regulated by IL-2, IL-7, and IL-15.
indirect
PMID: 17114416,15980098,12435740
Kovanen et al. analyzed T cell transcriptional responses to cytokine signaling through the common {gamma}-chain and identified DUSP5/VH3 and DUSP6/MKP-3 as up-regulated by IL-2, IL-7, and IL-15.
indirect
PMID: 17114416,15980098,12435740
Kovanen et al. analyzed T cell transcriptional responses to cytokine signaling through the common {gamma}-chain and identified DUSP5/VH3 and DUSP6/MKP-3 as up-regulated by IL-2, IL-7, and IL-15.
indirect
PMID: 17114416,15980098,12435740
Kovanen et al. analyzed T cell transcriptional responses to cytokine signaling through the common {gamma}-chain and identified DUSP5/VH3 and DUSP6/MKP-3 as up-regulated by IL-2, IL-7, and IL-15.
indirect
PMID: 17114416,15980098,12435740
Kovanen et al. analyzed T cell transcriptional responses to cytokine signaling through the common {gamma}-chain and identified DUSP5/VH3 and DUSP6/MKP-3 as up-regulated by IL-2, IL-7, and IL-15.
indirect
indirect
PMID: 17114416,16184516,12193690
Mining of transcriptome datasets from primary mouse macrophages stimulated with LPS or the RAW 264.7 macrophage cell line after activation with a set of TLR ligands, our laboratory identified DUSP1, DUSP2, and DUSP16 as the most strongly induced MKP; thus, there is substantial overlap between these studies in the human and mouse system
PMID: 17114416,12444149
However, the role of ERK signaling in DUSP1 mRNA expression is not entirely clear, because the MEK-1 inhibitor U0126 was reported to block LPS-induced increases of DUSP1 at the mRNA and protein level
PMID: 17114416,10604989,10452980
Celada and colleagues then showed that DUSP1 is induced by signaling through the M-CSF receptor as well as in response to LPS, and additionally demonstrated the involvement of PKC in this process.
indirect
PMID: 17114416,16184516,12193690
Mining of transcriptome datasets from primary mouse macrophages stimulated with LPS or the RAW 264.7 macrophage cell line after activation with a set of TLR ligands, our laboratory identified DUSP1, DUSP2, and DUSP16 as the most strongly induced MKP; thus, there is substantial overlap between these studies in the human and mouse system
indirect
PMID: 17114416,16184516,12193690
Mining of transcriptome datasets from primary mouse macrophages stimulated with LPS or the RAW 264.7 macrophage cell line after activation with a set of TLR ligands, our laboratory identified DUSP1, DUSP2, and DUSP16 as the most strongly induced MKP; thus, there is substantial overlap between these studies in the human and mouse system
indirect
PMID: 17114416,16184516,12193690
Mining of transcriptome datasets from primary mouse macrophages stimulated with LPS or the RAW 264.7 macrophage cell line after activation with a set of TLR ligands, our laboratory identified DUSP1, DUSP2, and DUSP16 as the most strongly induced MKP; thus, there is substantial overlap between these studies in the human and mouse system
indirect
PMID: 17114416,16184516,12193690
Mining of transcriptome datasets from primary mouse macrophages stimulated with LPS or the RAW 264.7 macrophage cell line after activation with a set of TLR ligands, our laboratory identified DUSP1, DUSP2, and DUSP16 as the most strongly induced MKP; thus, there is substantial overlap between these studies in the human and mouse system
indirect
PMID: 17114416,16184516,12193690
Mining of transcriptome datasets from primary mouse macrophages stimulated with LPS or the RAW 264.7 macrophage cell line after activation with a set of TLR ligands, our laboratory identified DUSP1, DUSP2, and DUSP16 as the most strongly induced MKP; thus, there is substantial overlap between these studies in the human and mouse system
indirect
indirect
PMID: 17114416,10604989,10452980
Celada and colleagues then showed that DUSP1 is induced by signaling through the M-CSF receptor as well as in response to LPS, and additionally demonstrated the involvement of PKC in this process.
indirect
PMID: 17114416,12444149
However, the role of ERK signaling in DUSP1 mRNA expression is not entirely clear, because the MEK-1 inhibitor U0126 was reported to block LPS-induced increases of DUSP1 at the mRNA and protein level
PMID: 17114416,10604989,10452980
Celada and colleagues then showed that DUSP1 is induced by signaling through the M-CSF receptor as well as in response to LPS, and additionally demonstrated the involvement of PKC in this process.
PMID: 17114416,16184516,12356755,15590669,11742987
Consistent with a negative regulatory function for DUSP1 in macrophage activation, anti-inflammatory glucocorticoids increase DUSP1 expression in macrophages, and mast cells at the mRNA and protein level
indirect
PMID: 17114416,10570180,16375603
Serine phosphorylation of STAT1 mediated by p38 MAPK represents another example of cross-talk that may be indirectly controlled by DUSP proteins and contribute to the shaping of the transcriptional responses
indirect
PMID: 17114416,12459177,9804857
Curiously, there are reports from two different groups suggesting that DUSP1 dephosphorylates STAT1 at tyrosine residues in hepatocytes and vascular smooth muscle cells, which would imply a more direct interaction with the JAK-STAT pathway
indirect
PMID: 17114416,16461893
TLR stimuli increase DUSP1 expression through MyD88- or, in the case of poly(I:C), TRIF-dependent signaling
indirect
PMID: 17114416,16461893
TLR stimuli increase DUSP1 expression through MyD88- or, in the case of poly(I:C), TRIF-dependent signaling
PMID: 17114416,8557667
MAPK signaling controls DUSP1 expression at various levels. In fibroblasts, activation of the JNK pathway, but not of ERK, resulted in increased DUSP1 mRNA
indirect
PMID: 17114416,16184516,12356755,15590669,11742987
Consistent with a negative regulatory function for DUSP1 in macrophage activation, anti-inflammatory glucocorticoids increase DUSP1 expression in macrophages, and mast cells at the mRNA and protein level
indirect
indirect
indirect
PMID: 17114416,16184516
Recently, we found that the immunosuppressive cytokine IL-10 enhanced and prolonged DUSP1 expression in TLR-stimulated macrophages, acting in synergy with dexamethasone.
PMID: 17114416,16387640
Finally, the anti-inflammatory effects of the endocannabinoid anandamide on microglia have recently been correlated to up-regulation of DUSP1 protein levels, suggesting that signaling through the CB2 receptor is another pathway that leads to dampened MAPK activation through increased DUSP1 levels
indirect
PMID: 17114416,16387640
Finally, the anti-inflammatory effects of the endocannabinoid anandamide on microglia have recently been correlated to up-regulation of DUSP1 protein levels, suggesting that signaling through the CB2 receptor is another pathway that leads to dampened MAPK activation through increased DUSP1 levels
PMID: 17114416,12444149,15590669,15485842
A negative effect of DUSP1 on macrophage activation was suggested by overexpression of DUSP1, which was shown in a number of studies to inhibit phosphorylation of MAPK and the production of the cytokines TNF-{alpha} and IL-6 in response to diverse TLR stimuli
indirect
indirect
indirect
PMID: 17114416,8649402
In another study, DUSP2 expression was found to be controlled by ERK activation
indirect
PMID: 17114416,8649402
In another study, DUSP2 expression was found to be controlled by ERK activation
PMID: 17114416,
DUSP2 is induced in macrophages by TLR ligands and in mast cells by Fc{epsilon}RI ligation.
indirect
PMID: 17114416,
DUSP2 is induced in macrophages by TLR ligands and in mast cells by Fc{epsilon}RI ligation.
indirect
PMID: 17114416, 8626452
Cloned in 1993 as an immediate early gene from TCR-activated T cells, DUSP2/PAC-1 localizes to the nucleus and primarily inactivates p38 MAPK and ERK in vitro
PMID: 17114416, 8626452
From overexpression studies in vitro, DUSP2 appeared to dephosphorylate p38 and ERK
indirect
PMID: 17114416, 8626452
Cloned in 1993 as an immediate early gene from TCR-activated T cells, DUSP2/PAC-1 localizes to the nucleus and primarily inactivates p38 MAPK and ERK in vitro
PMID: 17114416, 8626452
From overexpression studies in vitro, DUSP2 appeared to dephosphorylate p38 and ERK
PMID: 17114416
Figure 1
PMID: 17114416
Finally, the authors also showed that DUSP2 physically interacts with p38, JNK, and ERK, providing a basis for the cross-talk between MAPK that is suggested by the data
PMID: 17114416
Figure 1
PMID: 17114416
Finally, the authors also showed that DUSP2 physically interacts with p38, JNK, and ERK, providing a basis for the cross-talk between MAPK that is suggested by the data
PMID: 17114416
Figure 1
PMID: 17114416
Finally, the authors also showed that DUSP2 physically interacts with p38, JNK, and ERK, providing a basis for the cross-talk between MAPK that is suggested by the data
indirect
PMID: 17114416,11971021,16713974,15107845
For example, IL-10 production was inhibited by the Map2k1/MEK1 inhibitor U0126, whereas IL-12 expression was suppressed by inhibition of p38 with SB203580
indirect
PMID: 17114416,15067049,14607893
High levels of IL-10 along with low IL-12 production in response to TLR2 stimulation were shown to correlate with strong ERK activation, whereas TLR4, TLR5, or TLR9 ligands preferentially activated p38 and induced more IL-12
indirect
PMID: 17114416,15067049,14607893
High levels of IL-10 along with low IL-12 production in response to TLR2 stimulation were shown to correlate with strong ERK activation, whereas TLR4, TLR5, or TLR9 ligands preferentially activated p38 and induced more IL-12
indirect
PMID: 17114416,15067049,14607893
High levels of IL-10 along with low IL-12 production in response to TLR2 stimulation were shown to correlate with strong ERK activation, whereas TLR4, TLR5, or TLR9 ligands preferentially activated p38 and induced more IL-12
PMID: 17114416,15067049,14607893
High levels of IL-10 along with low IL-12 production in response to TLR2 stimulation were shown to correlate with strong ERK activation, whereas TLR4, TLR5, or TLR9 ligands preferentially activated p38 and induced more IL-12
indirect
PMID: 17114416,15067049,14607893
High levels of IL-10 along with low IL-12 production in response to TLR2 stimulation were shown to correlate with strong ERK activation, whereas TLR4, TLR5, or TLR9 ligands preferentially activated p38 and induced more IL-12
indirect
PMID: 17114416,15067049,14607893
High levels of IL-10 along with low IL-12 production in response to TLR2 stimulation were shown to correlate with strong ERK activation, whereas TLR4, TLR5, or TLR9 ligands preferentially activated p38 and induced more IL-12
indirect
PMID: 17114416,15067049,14607893
High levels of IL-10 along with low IL-12 production in response to TLR2 stimulation were shown to correlate with strong ERK activation, whereas TLR4, TLR5, or TLR9 ligands preferentially activated p38 and induced more IL-12PMID: 17114416,11861597,7914033,9799232,9794373
All three MAPK are phosphorylated on the threonine and tyrosine residues of the shared TxY motif within minutes after TLR stimulation of macrophages and dendritic cells (DC) , as shown early on for the TLR4 ligand LPSPMID: 17114416,11861597,7914033,9799232,9794373
All three MAPK are phosphorylated on the threonine and tyrosine residues of the shared TxY motif within minutes after TLR stimulation of macrophages and dendritic cells (DC) , as shown early on for the TLR4 ligand LPSindirectPMID: 17114416,11861597,7914033,9799232,9794373
All three MAPK are phosphorylated on the threonine and tyrosine residues of the shared TxY motif within minutes after TLR stimulation of macrophages and dendritic cells (DC) , as shown early on for the TLR4 ligand LPSindirectPMID: 17114416,11861597,7914033,9799232,9794373
All three MAPK are phosphorylated on the threonine and tyrosine residues of the shared TxY motif within minutes after TLR stimulation of macrophages and dendritic cells (DC) , as shown early on for the TLR4 ligand LPSindirectPMID: 17114416,11861597,7914033,9799232,9794373
All three MAPK are phosphorylated on the threonine and tyrosine residues of the shared TxY motif within minutes after TLR stimulation of macrophages and dendritic cells (DC) , as shown early on for the TLR4 ligand LPSindirectPMID: 17114416,11861597,7914033,9799232,9794373
All three MAPK are phosphorylated on the threonine and tyrosine residues of the shared TxY motif within minutes after TLR stimulation of macrophages and dendritic cells (DC) , as shown early on for the TLR4 ligand LPSindirectPMID: 17114416,11861597,7914033,9799232,9794373
All three MAPK are phosphorylated on the threonine and tyrosine residues of the shared TxY motif within minutes after TLR stimulation of macrophages and dendritic cells (DC) , as shown early on for the TLR4 ligand LPSindirectPMID: 17114416,11861597,7914033,9799232,9794373
All three MAPK are phosphorylated on the threonine and tyrosine residues of the shared TxY motif within minutes after TLR stimulation of macrophages and dendritic cells (DC) , as shown early on for the TLR4 ligand LPSindirectPMID: 17114416,11861597
Rapid transduction of the signal from TNFR-associated factor 6 to the MAPK is achieved through the sequential activation of upstream MAP3K and MAPK kinasesindirectPMID: 17114416,11861597
Rapid transduction of the signal from TNFR-associated factor 6 to the MAPK is achieved through the sequential activation of upstream MAP3K and MAPK kinasesPMID: 17114416
In CD4+ T cells, DUSP10 is constitutively expressed but down-regulated 24 h after TCR activation. indirectPMID: 17114416
In CD4+ T cells, DUSP10 is constitutively expressed but down-regulated 24 h after TCR activation.