majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:17082566.csml convertedTime:2009.07.01.10:58

Entity

G010227:IFNalpha G010262:IL-6 G010329:TNF-alpha MO000000212:TRAF6 MO000000213:IRAK1 MO000000289:TNF-alpha MO000007384:IL-6 MO000007702:IRF-7 MO000016573:MyD88 MO000016659:IFNalpha MO000019395:TLRs MO000019398:TLR3 MO000022224:dsRNA MO000041125:TRIF MO000041446:dsRNA:TLR3 MO000042007:TLR8 MO000042012:TLR9 MO000042126:TLR7 MO000103999:MDA5 e1: e10: e11: e12:poly I: C e13:poly I: C: TLR3 e14:imidazoquinilones e15:TLR ligand: TLR: MyD88 e16:ssRNA e17:imidazoquinilones : TLR8 e18:imidazoquinilones: TLR7 e19:ssRNA: TLR8 e2: e20:ssRNA: TLR7 e21:dsDNA e22:dsDNA: TLR9 e23:TLR ligand: TLR: TRIF e24:TLR ligand e25:TLR ligand: TLR e26:TLR ligand: TLR: MyD88: IRAK1 e27:TRAF6 {activated} e28:IRF-7 {activated} e29:small RNP e3: e30:small RNP: TLR7 e31:RIG-I e32:ssRNA: RIG-I e33:ssRNA: MDA5 e4: e5: e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6: e60: e61: e62: e7: e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p3 p4 p5 p6 p7 p8 p9
592.0, 1052.0
32.0, 32.0

IFNalpha

--

G010227

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p16 p17 p18 p19 p20

true true true true

csml-variable:Double

m93216

10

false

infinite

0

unit false false false
TRANSFACG010227

--

Go back
662.0, 930.0
28.0, 28.0

IL-6

--

G010262

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p14

true true true true

csml-variable:Double

m93248

10

false

infinite

0

unit false false false
TRANSFACG010262

--

Go back
620.0, 876.0
31.0, 31.0

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p12

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
608.0, 236.0
32.0, 32.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
552.0, 184.0
32.0, 32.0

IRAK1

--

MO000000213

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11

true true true true

csml-variable:Double

m184

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000213

--

Go back
816.0, 876.0
32.0, 32.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

p12

--

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
824.0, 928.0
32.0, 32.0

IL-6

--

MO000007384

cso30:c:Protein

cso30:i:CC_CellComponent

--

p14

--

true true true true

csml-variable:Double

m871

10

false

infinite

0

unit false false false
InterProIPR003573
TRANSPATHMO000007384

--

Go back
759.0, 231.0
34.0, 34.0

IRF-7

--

MO000007702

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15

true true true true

csml-variable:Double

m980

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
639.0, 183.0
34.0, 34.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
865.0, 1105.0
30.0, 30.0

IFNalpha

--

MO000016659

cso30:c:Protein

cso30:i:CC_CellComponent

--

p16 p17 p18 p19 p20

--

true true true true

csml-variable:Double

m1635

10

false

infinite

0

unit false false false
InterProIPR000471
TRANSPATHMO000016659

--

Go back
746.0, 126.0
28.0, 28.0

TLRs

--

MO000019395

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10

true true true true

csml-variable:Double

m3962

10

false

infinite

0

unit false false false
TRANSPATHMO000019395

--

Go back
304.0, 121.0
29.0, 29.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p2

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
382.0, 35.0
34.0, 34.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
777.0, 185.0
29.0, 29.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
377.0, 114.0
36.0, 36.0

dsRNA:TLR3

--

MO000041446

cso30:c:Protein

cso30:i:CC_CellComponent

--

p1

--

true true true true

csml-variable:Double

m19314

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
230.0, 494.0
28.0, 28.0

TLR8

--

MO000042007

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3 p4

true true true true

csml-variable:Double

m19823

10

false

infinite

0

unit false false false
TRANSPATHMO000042007

--

Go back
227.0, 723.0
26.0, 26.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
231.0, 595.0
25.0, 25.0

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5 p6 p21

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
201.0, 285.0
30.0, 30.0

MDA5

--

MO000103999

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24

true true true true

csml-variable:Double

m76904

10

false

infinite

0

unit false false false
TRANSPATHMO000103999

--

Go back
119.75, 96.99690800911759
856.2594311764528, 1243.2886940682085

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
128.0, 116.0
829.9775981223105, 1167.545103664102

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
230.0, 374.2871257087593
275.52428270722294, 459.9854550281604

--

e11

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false true false

--

Go back
202.0, 40.0
42.91841883936081, 24.32043734230446

poly I: C

--

e12

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p2

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
219.625, 112.5
31.1894267622063, 38.19113481086486

poly I: C: TLR3

--

e13

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p2

--

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
49.5, 599.25
45.0, 25.5

imidazoquinilones

--

e14

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p3 p6

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
595.625, 103.5
33.418555240793204, 40.92067988668556

TLR ligand: TLR: MyD88

--

e15

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p8

p11

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
45.5, 543.625
45.0, 24.75

ssRNA

--

e16

cso30:c:Rna

cso30:i:CC_Extracellular

--

--

p4 p5 p23 p24

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
486.625, 635.5
27.580361606398938, 33.7718713547742

imidazoquinilones : TLR8

--

e17

cso30:c:Complex

cso30:i:CC_Cytosol

--

p3

p17

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
445.625, 730.5
29.131769705049155, 35.67155474087652

imidazoquinilones: TLR7

--

e18

cso30:c:Complex

cso30:i:CC_Cytosol

--

p6

p19

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
472.625, 680.5
31.09960839860024, 38.08115314114315

ssRNA: TLR8

--

e19

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p4

p18

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
119.75, 96.99690800911759
856.2594311764528, 1243.2886940682085

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
401.625, 774.5
28.160098316947177, 34.48175304115981

ssRNA: TLR7

--

e20

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p5

p20

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
41.5, 788.125
45.0, 15.75

dsDNA

--

e21

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p7

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
229.625, 766.5
28.151933011164804, 34.47175470754874

dsDNA: TLR9

--

e22

cso30:c:Complex

cso30:i:CC_Cytosol

--

p7

--

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
821.625, 106.5
28.42955340776537, 34.81169805032494

TLR ligand: TLR: TRIF

--

e23

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p9

p15

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
620.5, 15.375
39.37609841827767, 25.59446397188049

TLR ligand

--

e24

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p10

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
696.625, 117.5
30.209590068321948, 36.99133477753708

TLR ligand: TLR

--

e25

cso30:c:Complex

cso30:i:CC_Extracellular

--

p10

p8 p9 p22

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
515.875, 117.5
32.25, 45.0

TLR ligand: TLR: MyD88: IRAK1

--

e26

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p11

p13

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
612.0, 292.0
32.0, 32.0

TRAF6 {activated}

--

e27

cso30:c:Protein

cso30:i:CC_CellComponent

--

p13

p12 p14

true true true true

csml-variable:Double

m27

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
763.0, 279.0
34.0, 34.0

IRF-7 {activated}

--

e28

cso30:c:Protein

cso30:i:CC_CellComponent

--

p15

p16

true true true true

csml-variable:Double

m28

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
348.5, 321.625
38.35892514395392, 21.097408829174665

small RNP

--

e29

cso30:c:Rna

cso30:i:CC_Cytosol

--

--

p21

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
136.87518862352903, 114.12209663264667
822.0090539293948, 1209.0383168211513

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
221.625, 434.5
29.139935010831532, 35.68155307448758

small RNP: TLR7

--

e30

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p21

--

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
198.375, 186.5
27.445079086115992, 42.2231985940246

RIG-I

--

e31

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p23

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
257.375, 243.5
21.61877877658408, 41.84279763209822

ssRNA: RIG-I

--

e32

cso30:c:Complex

cso30:i:CC_Cytosol

--

p23

--

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
253.625, 322.5
29.00112481253124, 35.511581403099484

ssRNA: MDA5

--

e33

cso30:c:Complex

cso30:i:CC_Cytosol

--

p24

--

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
168.55678757705792, 144.09117672382234
758.6458560223374, 1149.1001566387988

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
230.0, 374.2871257087593
275.52428270722294, 459.9854550281604

--

e5

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false true false

--

Go back
301.0, 814.0
465.6500709748862, 422.29345356567933

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
351.29367619468036, 824.0077409313898
272.27955732982184, 409.2864683429171

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
307.06992643728904, 819.6363602631969
453.51021810030846, 411.0207330392853

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
307.93705878547314, 820.503492611381
451.7759534039399, 409.2864683429171

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
301.0, 814.0
465.6500709748862, 422.29345356567933

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
301.0, 814.0
465.6500709748862, 422.29345356567933

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
307.93705878547314, 820.503492611381
451.7759534039399, 409.2864683429171

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
640.9158804881849, 987.4264696368292
29.091257918298922, 26.33524401024959

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
564.6082338479803, 1108.8249983826097
82.37757307749382, 74.57338194383664

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
301.0, 814.0
465.6500709748862, 422.29345356567933

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
230.0, 374.2871257087593
275.52428270722294, 459.9854550281604

--

e6

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false true false

--

Go back
410.7511016961721, 1001.6637213250546
14.746453546866459, 7.100144300343119

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
410.25867587120234, 980.4894108513561
50.4736470593979, 90.85256470691624

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
431.43298634490145, 1039.5805098477247
7.878813199515761, 7.8788131995157675

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
131.0, 102.0
839.7237354966342, 1189.8668429177399

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
134.0, 123.0
805.5569854171277, 1169.6687428256696

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
142.0, 144.0
801.8791759029863, 1154.3288303559784

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
329.0, 62.0
27.0, 27.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019398 MO000022224

MO000041446

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m3965*m119368*0.1

nodelay

--

true

0

false

PMID: 17082566 For the purposes of this review, it is important to highlight the four nucleic acid-sensing TLRs: TLR3 shows specificity for poly(I:C) compounds and dsRNA, while TLRs 7 and 8 recognize imidazoquinilones and ssRNA, and TLR9 binds dsDNA.

Go back
700.0, 16.0
23.0, 23.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e24 MO000019395

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c26 : 1
stoichiometry:c28 : 1

m24*m3962*0.1

nodelay

--

true

0

false

PMID: 17082566, 16410796, 15492225, 15361868 While some TLRs seem to rely mainly on MyD88 to produce cytokines like IL-6 and TNF-alpha, others also recruit adaptor molecules and transcription factors such as Toll/IL-1R-domain-containing adapter-inducing IFN-beta, TNFR-associated factor 6, IL-1R-associated kinase-1, and IFN regulatory factor-7 to potently stimulate the transcription of IFN-alpha.

Go back
555.0, 67.0
25.0, 25.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e15 MO000000213

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1
stoichiometry:c33 : 1

m15*m184*0.1

nodelay

--

true

0

false

PMID: 17082566, 16410796, 15492225, 15361868 While some TLRs seem to rely mainly on MyD88 to produce cytokines like IL-6 and TNF-alpha, others also recruit adaptor molecules and transcription factors such as Toll/IL-1R-domain-containing adapter-inducing IFN-beta, TNFR-associated factor 6, IL-1R-associated kinase-1, and IFN regulatory factor-7 to potently stimulate the transcription of IFN-alpha.

Go back
739.0, 879.0
25.0, 25.0

p12

p12

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010329 e27

MO000000289

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c39 : 1
stoichiometry:c41 : 1
stoichiometry:c37 : 1

m93309*m27*0.1

nodelay

--

true

0

false

PMID: 17082566, 16410796, 15492225, 15361868 While some TLRs seem to rely mainly on MyD88 to produce cytokines like IL-6 and TNF-alpha, others also recruit adaptor molecules and transcription factors such as Toll/IL-1R-domain-containing adapter-inducing IFN-beta, TNFR-associated factor 6, IL-1R-associated kinase-1, and IFN regulatory factor-7 to potently stimulate the transcription of IFN-alpha.

Go back
522.0, 294.0
27.0, 27.0

p13

p13

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000212 e26

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c36 : 1
stoichiometry:c35 : 1

m183*m26*0.1

nodelay

--

true

0

false

PMID: 17082566, 16410796, 15492225, 15361868 While some TLRs seem to rely mainly on MyD88 to produce cytokines like IL-6 and TNF-alpha, others also recruit adaptor molecules and transcription factors such as Toll/IL-1R-domain-containing adapter-inducing IFN-beta, TNFR-associated factor 6, IL-1R-associated kinase-1, and IFN regulatory factor-7 to potently stimulate the transcription of IFN-alpha.

Go back
775.0, 931.0
25.0, 25.0

p14

p14

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010262 e27

MO000007384

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c42 : 1
stoichiometry:c38 : 1

m93248*m27*0.1

nodelay

--

true

0

false

PMID: 17082566, 16410796, 15492225, 15361868 While some TLRs seem to rely mainly on MyD88 to produce cytokines like IL-6 and TNF-alpha, others also recruit adaptor molecules and transcription factors such as Toll/IL-1R-domain-containing adapter-inducing IFN-beta, TNFR-associated factor 6, IL-1R-associated kinase-1, and IFN regulatory factor-7 to potently stimulate the transcription of IFN-alpha.

Go back
821.0, 249.0
30.0, 30.0

p15

p15

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e23 MO000007702

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c44 : 1
stoichiometry:c45 : 1

m23*m980*0.1

nodelay

--

true

0

false

PMID: 17082566, 16410796, 15492225, 15361868 While some TLRs seem to rely mainly on MyD88 to produce cytokines like IL-6 and TNF-alpha, others also recruit adaptor molecules and transcription factors such as Toll/IL-1R-domain-containing adapter-inducing IFN-beta, TNFR-associated factor 6, IL-1R-associated kinase-1, and IFN regulatory factor-7 to potently stimulate the transcription of IFN-alpha.

Go back
799.0, 987.0
25.0, 25.0

p16

p16

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010227 e28

MO000016659

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c48 : 1
stoichiometry:c46 : 1

m93216*m28*0.1

nodelay

--

true

0

false

PMID: 17082566, 16410796, 15492225, 15361868 While some TLRs seem to rely mainly on MyD88 to produce cytokines like IL-6 and TNF-alpha, others also recruit adaptor molecules and transcription factors such as Toll/IL-1R-domain-containing adapter-inducing IFN-beta, TNFR-associated factor 6, IL-1R-associated kinase-1, and IFN regulatory factor-7 to potently stimulate the transcription of IFN-alpha.

Go back
793.0, 1037.0
25.0, 25.0

p17

p17

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010227 e17

MO000016659

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c53 : 1
stoichiometry:c57 : 1

m93216*m17*0.1

nodelay

--

true

0

false

PMID: 17082566, 16330816 So far, human studies have shown that sera from lupus patients can stimulate IFN-alpha production in a TLR7/8-dependent manner.

Go back
792.0, 1080.0
26.0, 26.0

p18

p18

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010227 e19

MO000016659

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c54 : 1
stoichiometry:c58 : 1

m93216*m19*0.1

nodelay

--

true

0

false

PMID: 17082566, 16330816 So far, human studies have shown that sera from lupus patients can stimulate IFN-alpha production in a TLR7/8-dependent manner.

Go back
775.0, 1115.0
25.0, 25.0

p19

p19

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010227 e18

MO000016659

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c55 : 1
stoichiometry:c59 : 1

m93216*m18*0.1

nodelay

--

true

0

false

PMID: 17082566, 16330816 So far, human studies have shown that sera from lupus patients can stimulate IFN-alpha production in a TLR7/8-dependent manner.

Go back
269.0, 66.0
27.0, 27.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019398 e12

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m3965*m12*0.1

nodelay

--

true

0

false

PMID: 17082566 For the purposes of this review, it is important to highlight the four nucleic acid-sensing TLRs: TLR3 shows specificity for poly(I:C) compounds and dsRNA, while TLRs 7 and 8 recognize imidazoquinilones and ssRNA, and TLR9 binds dsDNA.

Go back
755.0, 1147.0
25.0, 25.0

p20

p20

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010227 e20

MO000016659

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c56 : 1
stoichiometry:c60 : 1

m93216*m20*0.1

nodelay

--

true

0

false

PMID: 17082566, 16330816 So far, human studies have shown that sera from lupus patients can stimulate IFN-alpha production in a TLR7/8-dependent manner.

Go back
308.0, 440.0
23.0, 23.0

p21

p21

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

e29 MO000042126

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c62 : 1
stoichiometry:c63 : 1

m29*m19940*0.1

nodelay

--

true

0

false

PMID: 17082566, 16230478, 16330816, 16368889 Additionally, several studies have shown that endogenous mammalian ligands of TLR7 such as small RNPs are capable of stimulating B cells and plasmacytoid dendritic cells.

Go back
1005.0, 293.0
30.0, 30.0

p22

p22

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

e25

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c64 : 1

m25*0.1

nodelay

--

true

0

false

PMID: 17082566 It is probable that both dendritic cell and B cell Ag presentation are enhanced upon signaling through TLRs, which could drive Th cell development and activation.

Go back
56.0, 252.0
23.0, 23.0

p23

p23

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e31 e16

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c66 : 1
stoichiometry:c67 : 1

m31*m16*0.1

nodelay

--

true

0

false

PMID: 17082566, 16625202, 16413926 For example, the RNA-sensing helicases RIG-I and MDA5 have been characterized recently and implicated in antiviral inflammatory responses in a TLR-independent manner.

Go back
82.0, 326.0
27.0, 27.0

p24

p24

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000103999 e16

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1
stoichiometry:c69 : 1
stoichiometry:c70 : 1

m76904*m16*0.1

nodelay

--

true

0

false

--

Go back
180.0, 496.0
23.0, 23.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000042007 e14

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c11 : 1
stoichiometry:c15 : 1

m19823*m14*0.1

nodelay

--

true

0

false

PMID: 17082566 For the purposes of this review, it is important to highlight the four nucleic acid-sensing TLRs: TLR3 shows specificity for poly(I:C) compounds and dsRNA, while TLRs 7 and 8 recognize imidazoquinilones and ssRNA, and TLR9 binds dsDNA.

Go back
184.0, 544.0
23.0, 23.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

MO000042007 e16

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c8 : 1
stoichiometry:c13 : 1
stoichiometry:c16 : 1

m19823*m16*0.1

nodelay

--

true

0

false

PMID: 17082566 For the purposes of this review, it is important to highlight the four nucleic acid-sensing TLRs: TLR3 shows specificity for poly(I:C) compounds and dsRNA, while TLRs 7 and 8 recognize imidazoquinilones and ssRNA, and TLR9 binds dsDNA.

Go back
184.0, 656.0
23.0, 23.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000042126 e16

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c9 : 1
stoichiometry:c14 : 1
stoichiometry:c18 : 1

m19940*m16*0.1

nodelay

--

true

0

false

PMID: 17082566 For the purposes of this review, it is important to highlight the four nucleic acid-sensing TLRs: TLR3 shows specificity for poly(I:C) compounds and dsRNA, while TLRs 7 and 8 recognize imidazoquinilones and ssRNA, and TLR9 binds dsDNA.

Go back
184.0, 600.0
23.0, 23.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000042126 e14

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c12 : 1
stoichiometry:c17 : 1

m19940*m14*0.1

nodelay

--

true

0

false

PMID: 17082566 For the purposes of this review, it is important to highlight the four nucleic acid-sensing TLRs: TLR3 shows specificity for poly(I:C) compounds and dsRNA, while TLRs 7 and 8 recognize imidazoquinilones and ssRNA, and TLR9 binds dsDNA.

Go back
52.0, 724.0
23.0, 23.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000042012 e21

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1

m19828*m21*0.1

nodelay

--

true

0

false

PMID: 17082566 For the purposes of this review, it is important to highlight the four nucleic acid-sensing TLRs: TLR3 shows specificity for poly(I:C) compounds and dsRNA, while TLRs 7 and 8 recognize imidazoquinilones and ssRNA, and TLR9 binds dsDNA.

Go back
643.0, 67.0
25.0, 25.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016573 e25

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c29 : 1
stoichiometry:c24 : 1

m1572*m25*0.1

nodelay

--

true

0

false

PMID: 17082566, 16410796, 15492225, 15361868 While some TLRs seem to rely mainly on MyD88 to produce cytokines like IL-6 and TNF-alpha, others also recruit adaptor molecules and transcription factors such as Toll/IL-1R-domain-containing adapter-inducing IFN-beta, TNFR-associated factor 6, IL-1R-associated kinase-1, and IFN regulatory factor-7 to potently stimulate the transcription of IFN-alpha.

Go back
780.0, 56.0
23.0, 23.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000041125 e25

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c30 : 1
stoichiometry:c27 : 1

m18998*m25*0.1

nodelay

--

true

0

false

PMID: 17082566, 16410796, 15492225, 15361868 While some TLRs seem to rely mainly on MyD88 to produce cytokines like IL-6 and TNF-alpha, others also recruit adaptor molecules and transcription factors such as Toll/IL-1R-domain-containing adapter-inducing IFN-beta, TNFR-associated factor 6, IL-1R-associated kinase-1, and IFN regulatory factor-7 to potently stimulate the transcription of IFN-alpha.

Go back
295.326060730508, 99.72942780301243

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
214.97236606595902, 609.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
87.0, 523.2542459584336

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
95.0, 612.0

c12

c12

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
91.0, 556.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
82.0, 568.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
203.0, 513.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
207.0, 561.0

c16

c16

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
207.0, 618.0

c17

c17

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
207.0, 674.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
83.0, 736.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
245.0, 63.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
64.0, 755.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
75.0, 739.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
660.0, 28.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
656.0, 100.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
634.6568542494924, 92.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
792.0, 87.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
720.1309168643905, 46.36188560005348

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
800.0, 79.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
712.0, 39.0

c28

c28

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
673.6568542494924, 97.65685424949238

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
256.3813823519705, 93.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
727.0, 83.17784657548758

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
585.6568542494924, 97.65685424949238

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
568.0, 100.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
549.9977796279167, 92.0

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
555.7257215188587, 262.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
549.0, 308.0

c35

c35

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
533.0, 163.0

c36

c36

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
764.0, 892.0

c37

c37

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
800.0, 944.0

c38

c38

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
651.0, 892.0

c39

c39

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
325.0, 96.41173261697847

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
690.0, 944.0

c40

c40

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
631.0, 324.0

c41

c41

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
632.0, 324.0

c42

c42

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
836.0, 141.0

c43

c43

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
793.0, 253.0

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
803.9102312071875, 272.0

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
819.0, 1012.0

c46

c46

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
624.0, 1006.5557984638539

c47

c47

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
781.0, 313.0

c48

c48

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
624.0, 1051.754024724077

c49

c49

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
363.3677380085485, 59.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
624.0, 1070.0

c50

c50

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
624.0, 1073.0

c51

c51

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
624.0, 1077.0

c52

c52

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
513.0, 669.0

c53

c53

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
503.0, 719.0

c54

c54

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
475.0, 765.0

c55

c55

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
430.0, 806.0

c56

c56

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
818.0, 1061.0

c57

c57

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
818.0, 1098.0

c58

c58

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
800.0, 1121.7353353937362

c59

c59

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
355.0, 89.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
780.0, 1127.7410427608056

c60

c60

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
327.9843139777272, 343.0

c61

c61

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
250.0, 470.1770339065574

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
259.0, 452.0

c63

c63

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
727.0, 144.0

c64

c64

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
86.44067968072669, 213.0

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
68.0, 283.0

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
79.0, 264.0

c67

c67

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
116.58118570263419, 305.0

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
70.0, 360.9375820117202

c69

c69

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
211.0, 508.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
109.0, 340.0

c70

c70

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
212.65685424949237, 522.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
210.91152490811936, 620.0

c9

c9

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back