Entity
IFNalpha
--
G010227
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m93216
10
infinite
0
TRANSFAC | G010227 |
--
IFNalpha
--
MO000016659
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m1635
10
infinite
0
InterPro | IPR000471 |
TRANSPATH | MO000016659 |
--
TLR7
--
MO000042126
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m19940
10
infinite
0
TRANSPATH | MO000042126 |
--
--
e1
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane
--
--
--
csml-variable:Double
m1
0
infinite
0
--
--
e10
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytosol
--
--
--
csml-variable:Double
m10
0
infinite
0
--
--
e11
cso30:c:EntityBiologicalCompartment
cso30:i:CC_EndosomeMembrane
--
--
--
csml-variable:Double
m11
0
infinite
0
--
poly I: C
--
e12
cso30:c:SmallMolecule
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m12
0
infinite
0
--
poly I: C: TLR3
--
e13
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m13
0
infinite
0
--
imidazoquinilones
--
e14
cso30:c:SmallMolecule
cso30:i:CC_Extracellular
--
csml-variable:Double
m14
0
infinite
0
--
TLR ligand: TLR: MyD88
--
e15
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m15
0
infinite
0
--
csml-variable:Double
m16
0
infinite
0
--
imidazoquinilones : TLR8
--
e17
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m17
0
infinite
0
--
imidazoquinilones: TLR7
--
e18
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m18
0
infinite
0
--
ssRNA: TLR8
--
e19
cso30:c:Complex
cso30:i:CC_EndosomeLumen
--
csml-variable:Double
m19
0
infinite
0
--
--
e2
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m2
0
infinite
0
--
ssRNA: TLR7
--
e20
cso30:c:Complex
cso30:i:CC_EndosomeLumen
--
csml-variable:Double
m20
0
infinite
0
--
csml-variable:Double
m21
0
infinite
0
--
dsDNA: TLR9
--
e22
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m22
0
infinite
0
--
TLR ligand: TLR: TRIF
--
e23
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m23
0
infinite
0
--
TLR ligand
--
e24
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m24
0
infinite
0
--
TLR ligand: TLR
--
e25
cso30:c:Complex
cso30:i:CC_Extracellular
--
csml-variable:Double
m25
0
infinite
0
--
TLR ligand: TLR: MyD88: IRAK1
--
e26
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m26
0
infinite
0
--
TRAF6 {activated}
--
e27
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m27
10
infinite
0
InterPro | IPR001841 |
TRANSPATH | MO000000212 |
--
IRF-7 {activated}
--
e28
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m28
10
infinite
0
TRANSPATH | MO000007702 |
--
small RNP
--
e29
cso30:c:Rna
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m29
0
infinite
0
--
--
e3
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
--
csml-variable:Double
m3
0
infinite
0
--
small RNP: TLR7
--
e30
cso30:c:Complex
cso30:i:CC_EndosomeMembrane
--
--
csml-variable:Double
m30
0
infinite
0
--
RIG-I
--
e31
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m31
0
infinite
0
--
ssRNA: RIG-I
--
e32
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m32
0
infinite
0
--
ssRNA: MDA5
--
e33
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m33
0
infinite
0
--
--
e4
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m4
0
infinite
0
--
--
e5
cso30:c:EntityBiologicalCompartment
cso30:i:CC_EndosomeLumen
--
--
--
csml-variable:Double
m5
0
infinite
0
--
--
e50
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelopeLumen
--
--
--
csml-variable:Double
m50
0
infinite
0
--
--
e51
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearPore
--
--
--
csml-variable:Double
m51
0
infinite
0
--
--
e52
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearInnerMembrane
--
--
--
csml-variable:Double
m52
0
infinite
0
--
--
e53
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearLumen
--
--
--
csml-variable:Double
m53
0
infinite
0
--
--
e54
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearOuterMembrane
--
--
--
csml-variable:Double
m54
0
infinite
0
--
--
e55
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleus
--
--
--
csml-variable:Double
m55
0
infinite
0
--
--
e56
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleoplasm
--
--
--
csml-variable:Double
m56
0
infinite
0
--
--
e57
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearBody
--
--
--
csml-variable:Double
m57
0
infinite
0
--
--
e58
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleolus
--
--
--
csml-variable:Double
m58
0
infinite
0
--
--
e59
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelope
--
--
--
csml-variable:Double
m59
0
infinite
0
--
--
e6
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Endosome
--
--
--
csml-variable:Double
m6
0
infinite
0
--
--
e60
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Chromatin
--
--
--
csml-variable:Double
m60
0
infinite
0
--
--
e61
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearChromosome
--
--
--
csml-variable:Double
m61
0
infinite
0
--
--
e62
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearCentromere
--
--
--
csml-variable:Double
m62
0
infinite
0
--
--
e7
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell
--
--
--
csml-variable:Double
m7
0
infinite
0
--
--
e8
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell_WithoutCellWall_
--
--
--
csml-variable:Double
m8
0
infinite
0
--
--
e9
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytoplasm
--
--
--
csml-variable:Double
m9
0
infinite
0
--
p1
p1
cso30:i:ME_Binding
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1
m3965*m119368*0.1
nodelay
--
0
PMID: 17082566 For the purposes of this review, it is important to highlight the four nucleic acid-sensing TLRs: TLR3 shows specificity for poly(I:C) compounds and dsRNA, while TLRs 7 and 8 recognize imidazoquinilones and ssRNA, and TLR9 binds dsDNA.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c26 : 1
stoichiometry:c28 : 1
m24*m3962*0.1
nodelay
--
0
PMID: 17082566, 16410796, 15492225, 15361868 While some TLRs seem to rely mainly on MyD88 to produce cytokines like IL-6 and TNF-alpha, others also recruit adaptor molecules and transcription factors such as Toll/IL-1R-domain-containing adapter-inducing IFN-beta, TNFR-associated factor 6, IL-1R-associated kinase-1, and IFN regulatory factor-7 to potently stimulate the transcription of IFN-alpha.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1
stoichiometry:c33 : 1
m15*m184*0.1
nodelay
--
0
PMID: 17082566, 16410796, 15492225, 15361868 While some TLRs seem to rely mainly on MyD88 to produce cytokines like IL-6 and TNF-alpha, others also recruit adaptor molecules and transcription factors such as Toll/IL-1R-domain-containing adapter-inducing IFN-beta, TNFR-associated factor 6, IL-1R-associated kinase-1, and IFN regulatory factor-7 to potently stimulate the transcription of IFN-alpha.
p12
p12
cso30:i:ME_Translation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c39 : 1
stoichiometry:c41 : 1
stoichiometry:c37 : 1
m93309*m27*0.1
nodelay
--
0
PMID: 17082566, 16410796, 15492225, 15361868 While some TLRs seem to rely mainly on MyD88 to produce cytokines like IL-6 and TNF-alpha, others also recruit adaptor molecules and transcription factors such as Toll/IL-1R-domain-containing adapter-inducing IFN-beta, TNFR-associated factor 6, IL-1R-associated kinase-1, and IFN regulatory factor-7 to potently stimulate the transcription of IFN-alpha.
p13
p13
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c36 : 1
stoichiometry:c35 : 1
m183*m26*0.1
nodelay
--
0
PMID: 17082566, 16410796, 15492225, 15361868 While some TLRs seem to rely mainly on MyD88 to produce cytokines like IL-6 and TNF-alpha, others also recruit adaptor molecules and transcription factors such as Toll/IL-1R-domain-containing adapter-inducing IFN-beta, TNFR-associated factor 6, IL-1R-associated kinase-1, and IFN regulatory factor-7 to potently stimulate the transcription of IFN-alpha.
p14
p14
cso30:i:ME_Translation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c42 : 1
stoichiometry:c38 : 1
m93248*m27*0.1
nodelay
--
0
PMID: 17082566, 16410796, 15492225, 15361868 While some TLRs seem to rely mainly on MyD88 to produce cytokines like IL-6 and TNF-alpha, others also recruit adaptor molecules and transcription factors such as Toll/IL-1R-domain-containing adapter-inducing IFN-beta, TNFR-associated factor 6, IL-1R-associated kinase-1, and IFN regulatory factor-7 to potently stimulate the transcription of IFN-alpha.
p15
p15
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c44 : 1
stoichiometry:c45 : 1
m23*m980*0.1
nodelay
--
0
PMID: 17082566, 16410796, 15492225, 15361868 While some TLRs seem to rely mainly on MyD88 to produce cytokines like IL-6 and TNF-alpha, others also recruit adaptor molecules and transcription factors such as Toll/IL-1R-domain-containing adapter-inducing IFN-beta, TNFR-associated factor 6, IL-1R-associated kinase-1, and IFN regulatory factor-7 to potently stimulate the transcription of IFN-alpha.
p16
p16
cso30:i:ME_Translation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c48 : 1
stoichiometry:c46 : 1
m93216*m28*0.1
nodelay
--
0
PMID: 17082566, 16410796, 15492225, 15361868 While some TLRs seem to rely mainly on MyD88 to produce cytokines like IL-6 and TNF-alpha, others also recruit adaptor molecules and transcription factors such as Toll/IL-1R-domain-containing adapter-inducing IFN-beta, TNFR-associated factor 6, IL-1R-associated kinase-1, and IFN regulatory factor-7 to potently stimulate the transcription of IFN-alpha.
p17
p17
cso30:i:ME_Translation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c53 : 1
stoichiometry:c57 : 1
m93216*m17*0.1
nodelay
--
0
PMID: 17082566, 16330816 So far, human studies have shown that sera from lupus patients can stimulate IFN-alpha production in a TLR7/8-dependent manner.
p18
p18
cso30:i:ME_Translation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c54 : 1
stoichiometry:c58 : 1
m93216*m19*0.1
nodelay
--
0
PMID: 17082566, 16330816 So far, human studies have shown that sera from lupus patients can stimulate IFN-alpha production in a TLR7/8-dependent manner.
p19
p19
cso30:i:ME_Translation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c55 : 1
stoichiometry:c59 : 1
m93216*m18*0.1
nodelay
--
0
PMID: 17082566, 16330816 So far, human studies have shown that sera from lupus patients can stimulate IFN-alpha production in a TLR7/8-dependent manner.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1
m3965*m12*0.1
nodelay
--
0
PMID: 17082566 For the purposes of this review, it is important to highlight the four nucleic acid-sensing TLRs: TLR3 shows specificity for poly(I:C) compounds and dsRNA, while TLRs 7 and 8 recognize imidazoquinilones and ssRNA, and TLR9 binds dsDNA.
p20
p20
cso30:i:ME_Translation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c56 : 1
stoichiometry:c60 : 1
m93216*m20*0.1
nodelay
--
0
PMID: 17082566, 16330816 So far, human studies have shown that sera from lupus patients can stimulate IFN-alpha production in a TLR7/8-dependent manner.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c62 : 1
stoichiometry:c63 : 1
m29*m19940*0.1
nodelay
--
0
PMID: 17082566, 16230478, 16330816, 16368889 Additionally, several studies have shown that endogenous mammalian ligands of TLR7 such as small RNPs are capable of stimulating B cells and plasmacytoid dendritic cells.
PMID: 17082566 It is probable that both dendritic cell and B cell Ag presentation are enhanced upon signaling through TLRs, which could drive Th cell development and activation.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c66 : 1
stoichiometry:c67 : 1
m31*m16*0.1
nodelay
--
0
PMID: 17082566, 16625202, 16413926 For example, the RNA-sensing helicases RIG-I and MDA5 have been characterized recently and implicated in antiviral inflammatory responses in a TLR-independent manner.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1
stoichiometry:c69 : 1
stoichiometry:c70 : 1
m76904*m16*0.1
nodelay
--
0
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c11 : 1
stoichiometry:c15 : 1
m19823*m14*0.1
nodelay
--
0
PMID: 17082566 For the purposes of this review, it is important to highlight the four nucleic acid-sensing TLRs: TLR3 shows specificity for poly(I:C) compounds and dsRNA, while TLRs 7 and 8 recognize imidazoquinilones and ssRNA, and TLR9 binds dsDNA.
p4
p4
cso30:i:ME_Binding
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c8 : 1
stoichiometry:c13 : 1
stoichiometry:c16 : 1
m19823*m16*0.1
nodelay
--
0
PMID: 17082566 For the purposes of this review, it is important to highlight the four nucleic acid-sensing TLRs: TLR3 shows specificity for poly(I:C) compounds and dsRNA, while TLRs 7 and 8 recognize imidazoquinilones and ssRNA, and TLR9 binds dsDNA.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c9 : 1
stoichiometry:c14 : 1
stoichiometry:c18 : 1
m19940*m16*0.1
nodelay
--
0
PMID: 17082566 For the purposes of this review, it is important to highlight the four nucleic acid-sensing TLRs: TLR3 shows specificity for poly(I:C) compounds and dsRNA, while TLRs 7 and 8 recognize imidazoquinilones and ssRNA, and TLR9 binds dsDNA.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c12 : 1
stoichiometry:c17 : 1
m19940*m14*0.1
nodelay
--
0
PMID: 17082566 For the purposes of this review, it is important to highlight the four nucleic acid-sensing TLRs: TLR3 shows specificity for poly(I:C) compounds and dsRNA, while TLRs 7 and 8 recognize imidazoquinilones and ssRNA, and TLR9 binds dsDNA.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1
m19828*m21*0.1
nodelay
--
0
PMID: 17082566 For the purposes of this review, it is important to highlight the four nucleic acid-sensing TLRs: TLR3 shows specificity for poly(I:C) compounds and dsRNA, while TLRs 7 and 8 recognize imidazoquinilones and ssRNA, and TLR9 binds dsDNA.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c29 : 1
stoichiometry:c24 : 1
m1572*m25*0.1
nodelay
--
0
PMID: 17082566, 16410796, 15492225, 15361868 While some TLRs seem to rely mainly on MyD88 to produce cytokines like IL-6 and TNF-alpha, others also recruit adaptor molecules and transcription factors such as Toll/IL-1R-domain-containing adapter-inducing IFN-beta, TNFR-associated factor 6, IL-1R-associated kinase-1, and IFN regulatory factor-7 to potently stimulate the transcription of IFN-alpha.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c30 : 1
stoichiometry:c27 : 1
m18998*m25*0.1
nodelay
--
0
PMID: 17082566, 16410796, 15492225, 15361868 While some TLRs seem to rely mainly on MyD88 to produce cytokines like IL-6 and TNF-alpha, others also recruit adaptor molecules and transcription factors such as Toll/IL-1R-domain-containing adapter-inducing IFN-beta, TNFR-associated factor 6, IL-1R-associated kinase-1, and IFN regulatory factor-7 to potently stimulate the transcription of IFN-alpha.
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--