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For the purposes of this review, it is important to highlight the four nucleic acid-sensing TLRs: TLR3 shows specificity for poly(I:C) compounds and dsRNA, while TLRs 7 and 8 recognize imidazoquinilones and ssRNA, and TLR9 binds dsDNA.</csml:comment>
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<csml:comment type="text">PMID: 17082566
For the purposes of this review, it is important to highlight the four nucleic acid-sensing TLRs: TLR3 shows specificity for poly(I:C) compounds and dsRNA, while TLRs 7 and 8 recognize imidazoquinilones and ssRNA, and TLR9 binds dsDNA.</csml:comment>
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For the purposes of this review, it is important to highlight the four nucleic acid-sensing TLRs: TLR3 shows specificity for poly(I:C) compounds and dsRNA, while TLRs 7 and 8 recognize imidazoquinilones and ssRNA, and TLR9 binds dsDNA.</csml:comment>
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For the purposes of this review, it is important to highlight the four nucleic acid-sensing TLRs: TLR3 shows specificity for poly(I:C) compounds and dsRNA, while TLRs 7 and 8 recognize imidazoquinilones and ssRNA, and TLR9 binds dsDNA.</csml:comment>
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<csml:comment type="text">PMID: 17082566
For the purposes of this review, it is important to highlight the four nucleic acid-sensing TLRs: TLR3 shows specificity for poly(I:C) compounds and dsRNA, while TLRs 7 and 8 recognize imidazoquinilones and ssRNA, and TLR9 binds dsDNA.</csml:comment>
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<csml:comment type="text">PMID: 17082566
For the purposes of this review, it is important to highlight the four nucleic acid-sensing TLRs: TLR3 shows specificity for poly(I:C) compounds and dsRNA, while TLRs 7 and 8 recognize imidazoquinilones and ssRNA, and TLR9 binds dsDNA.</csml:comment>
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<csml:comment type="text">PMID: 17082566
For the purposes of this review, it is important to highlight the four nucleic acid-sensing TLRs: TLR3 shows specificity for poly(I:C) compounds and dsRNA, while TLRs 7 and 8 recognize imidazoquinilones and ssRNA, and TLR9 binds dsDNA.</csml:comment>
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While some TLRs seem to rely mainly on MyD88 to produce cytokines like IL-6 and TNF-alpha, others also recruit adaptor molecules and transcription factors such as Toll/IL-1R-domain-containing adapter-inducing IFN-beta, TNFR-associated factor 6, IL-1R-associated kinase-1, and IFN regulatory factor-7 to potently stimulate the transcription of IFN-alpha.</csml:comment>
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While some TLRs seem to rely mainly on MyD88 to produce cytokines like IL-6 and TNF-alpha, others also recruit adaptor molecules and transcription factors such as Toll/IL-1R-domain-containing adapter-inducing IFN-beta, TNFR-associated factor 6, IL-1R-associated kinase-1, and IFN regulatory factor-7 to potently stimulate the transcription of IFN-alpha.</csml:comment>
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<csml:comment type="text">PMID: 17082566, 16410796, 15492225, 15361868
While some TLRs seem to rely mainly on MyD88 to produce cytokines like IL-6 and TNF-alpha, others also recruit adaptor molecules and transcription factors such as Toll/IL-1R-domain-containing adapter-inducing IFN-beta, TNFR-associated factor 6, IL-1R-associated kinase-1, and IFN regulatory factor-7 to potently stimulate the transcription of IFN-alpha.</csml:comment>
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<csml:comment type="text">PMID: 17082566, 16410796, 15492225, 15361868
While some TLRs seem to rely mainly on MyD88 to produce cytokines like IL-6 and TNF-alpha, others also recruit adaptor molecules and transcription factors such as Toll/IL-1R-domain-containing adapter-inducing IFN-beta, TNFR-associated factor 6, IL-1R-associated kinase-1, and IFN regulatory factor-7 to potently stimulate the transcription of IFN-alpha.</csml:comment>
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<csml:comments>
<csml:comment type="text">Indirect</csml:comment>
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<csml:comment type="text">PMID: 17082566, 16410796, 15492225, 15361868
While some TLRs seem to rely mainly on MyD88 to produce cytokines like IL-6 and TNF-alpha, others also recruit adaptor molecules and transcription factors such as Toll/IL-1R-domain-containing adapter-inducing IFN-beta, TNFR-associated factor 6, IL-1R-associated kinase-1, and IFN regulatory factor-7 to potently stimulate the transcription of IFN-alpha.</csml:comment>
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<csml:comment type="text">PMID: 17082566, 16410796, 15492225, 15361868
While some TLRs seem to rely mainly on MyD88 to produce cytokines like IL-6 and TNF-alpha, others also recruit adaptor molecules and transcription factors such as Toll/IL-1R-domain-containing adapter-inducing IFN-beta, TNFR-associated factor 6, IL-1R-associated kinase-1, and IFN regulatory factor-7 to potently stimulate the transcription of IFN-alpha.</csml:comment>
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<csml:comment type="text">PMID: 17082566, 16410796, 15492225, 15361868
While some TLRs seem to rely mainly on MyD88 to produce cytokines like IL-6 and TNF-alpha, others also recruit adaptor molecules and transcription factors such as Toll/IL-1R-domain-containing adapter-inducing IFN-beta, TNFR-associated factor 6, IL-1R-associated kinase-1, and IFN regulatory factor-7 to potently stimulate the transcription of IFN-alpha.</csml:comment>
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<csml:comment type="text">PMID: 17082566, 16410796, 15492225, 15361868
While some TLRs seem to rely mainly on MyD88 to produce cytokines like IL-6 and TNF-alpha, others also recruit adaptor molecules and transcription factors such as Toll/IL-1R-domain-containing adapter-inducing IFN-beta, TNFR-associated factor 6, IL-1R-associated kinase-1, and IFN regulatory factor-7 to potently stimulate the transcription of IFN-alpha.</csml:comment>
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<csml:comment type="text">PMID: 17082566, 16410796, 15492225, 15361868
While some TLRs seem to rely mainly on MyD88 to produce cytokines like IL-6 and TNF-alpha, others also recruit adaptor molecules and transcription factors such as Toll/IL-1R-domain-containing adapter-inducing IFN-beta, TNFR-associated factor 6, IL-1R-associated kinase-1, and IFN regulatory factor-7 to potently stimulate the transcription of IFN-alpha.</csml:comment>
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So far, human studies have shown that sera from lupus patients can stimulate IFN-alpha production in a TLR7/8-dependent manner.</csml:comment>
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So far, human studies have shown that sera from lupus patients can stimulate IFN-alpha production in a TLR7/8-dependent manner.</csml:comment>
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So far, human studies have shown that sera from lupus patients can stimulate IFN-alpha production in a TLR7/8-dependent manner.</csml:comment>
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So far, human studies have shown that sera from lupus patients can stimulate IFN-alpha production in a TLR7/8-dependent manner.</csml:comment>
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<csml:comment type="text">PMID: 17082566, 16230478, 16330816, 16368889
Additionally, several studies have shown that endogenous mammalian ligands of TLR7 such as small RNPs are capable of stimulating B cells and plasmacytoid dendritic cells.</csml:comment>
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It is probable that both dendritic cell and B cell Ag presentation are enhanced upon signaling through TLRs, which could drive Th cell development and activation.</csml:comment>
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<csml:comment type="text">PMID: 17082566, 16625202, 16413926
For example, the RNA-sensing helicases RIG-I and MDA5 have been characterized recently and implicated in antiviral inflammatory responses in a TLR-independent manner.</csml:comment>
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