Entity
IL-1beta
--
G010389
cso30:c:mRNA
cso30:i:CC_CellComponent
--
csml-variable:Double
m93364
10
infinite
0
TRANSFAC | G010389 |
--
TNF-alpha
--
MO000000289
cso30:c:Protein
cso30:i:CC_CellComponent
--
--
csml-variable:Double
m230
10
infinite
0
InterPro | IPR003636 |
TRANSPATH | MO000000289 |
--
IL-1beta
--
MO000016597
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m1591
10
infinite
0
TRANSPATH | MO000016597 |
--
IL-1RA
--
MO000016598
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m1592
10
infinite
0
InterPro | IPR003297 |
TRANSPATH | MO000016598 |
--
fibronectin
--
MO000017549
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m2341
10
infinite
0
InterPro | IPR006209 |
TRANSPATH | MO000017549 |
--
proIL-1beta
--
MO000019449
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m4012
10
infinite
0
InterPro | IPR003297 |
TRANSPATH | MO000019449 |
--
IL-1RI:IL-1RA
--
MO000039107
cso30:c:Protein
cso30:i:CC_CellComponent
--
--
csml-variable:Double
m17283
10
infinite
0
TRANSPATH | MO000039107 |
--
collagen
--
MO000083632
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m57739
10
infinite
0
TRANSPATH | MO000083632 |
--
--
e1
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane
--
--
--
csml-variable:Double
m1
0
infinite
0
--
Beta1-integrin:Beta1-integrin antibody
--
e10
cso30:c:Complex
cso30:i:CC_Cytoplasm
--
csml-variable:Double
m10
0
infinite
0
--
IL-1beta:IL-1RII
--
e12
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m12
0
infinite
0
--
pro IL-1beta:IL-1RII
--
e13
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m13
0
infinite
0
--
Fibronectin:Heparin
--
e14
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m14
0
infinite
0
--
Fibronectin:collagen
--
e15
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m15
0
infinite
0
--
Fibronectin:Fibrinogen
--
e16
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m16
0
infinite
0
--
Cellular surface integrin receptors
--
e17
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m17
0
infinite
0
--
Fibronectin:cellular surface integrin receptors
--
e18
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m18
0
infinite
0
--
GM-CSF:GM-CSFR
--
e19
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m19
0
infinite
0
--
--
e2
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m2
0
infinite
0
--
IL-1ra
--
e20
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m20
0
infinite
0
--
TNF-alpha receptor
--
e21
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m21
0
infinite
0
--
TNF-alpha:receptor
--
e22
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m22
0
infinite
0
--
Bacteria
--
e23
cso30:c:Cell
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m23
0
infinite
0
--
surface receptor
--
e24
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m24
0
infinite
0
--
Bacteria:surface receptor
--
e25
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m25
0
infinite
0
--
Beta1-integrin antibody
--
e26
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m26
0
infinite
0
--
csml-variable:Double
m27
0
infinite
0
--
pp76{p}
--
e28
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m28
0
infinite
0
--
pp76
--
e29
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m29
0
infinite
0
--
--
e3
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
--
csml-variable:Double
m3
0
infinite
0
--
Anti Beta1-integrin
--
e30
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m30
0
infinite
0
--
antibet3-integrin antibody
--
e31
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m31
0
infinite
0
--
IL-1beta:IL-1RI
--
e32
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m32
0
infinite
0
--
--
e4
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m4
0
infinite
0
--
ICE
--
e5
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m5
0
infinite
0
--
--
e50
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelopeLumen
--
--
--
csml-variable:Double
m50
0
infinite
0
--
--
e51
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearPore
--
--
--
csml-variable:Double
m51
0
infinite
0
--
--
e52
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearInnerMembrane
--
--
--
csml-variable:Double
m52
0
infinite
0
--
--
e53
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearLumen
--
--
--
csml-variable:Double
m53
0
infinite
0
--
--
e54
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearOuterMembrane
--
--
--
csml-variable:Double
m54
0
infinite
0
--
--
e55
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleus
--
--
--
csml-variable:Double
m55
0
infinite
0
--
--
e56
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleoplasm
--
--
--
csml-variable:Double
m56
0
infinite
0
--
--
e57
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearBody
--
--
--
csml-variable:Double
m57
0
infinite
0
--
--
e58
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleolus
--
--
--
csml-variable:Double
m58
0
infinite
0
--
--
e59
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelope
--
--
--
csml-variable:Double
m59
0
infinite
0
--
Pro IL-1alpha
--
e6
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m6
0
infinite
0
--
--
e60
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Chromatin
--
--
--
csml-variable:Double
m60
0
infinite
0
--
--
e61
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearChromosome
--
--
--
csml-variable:Double
m61
0
infinite
0
--
--
e62
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearCentromere
--
--
--
csml-variable:Double
m62
0
infinite
0
--
--
e7
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell
--
--
--
csml-variable:Double
m7
0
infinite
0
--
--
e8
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell_WithoutCellWall_
--
--
--
csml-variable:Double
m8
0
infinite
0
--
--
e9
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytoplasm
--
--
--
csml-variable:Double
m9
0
infinite
0
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c3 : 1
stoichiometry:c2 : 1
m4012*m5*0.1
nodelay
--
0
PMID: 16978691, The two agonists, IL-1greek alpha and IL-1beta, both initially are synthesized as 31 kDa precursors, pro-IL-1greek small letter alpha and pro-IL-1¦Â, which are then cleaved into their mature 17 kDa forms PMID: 16978691 IL-18 is cleaved via the same enzyme, IL-1 converting enzyme (ICE), as IL-1¦Â, although the biological effects can differ.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c26 : 1
stoichiometry:c27 : 1
stoichiometry:c28 : 1
m17*m2341*0.1
nodelay
--
0
PMID: 16978691,12244123,10077553 FN contains multiple binding sites which bind to other molecules such as heparin (heparin I and II), collagen (Type I module, domains 6?9 (I6¡Ý9) and Type II module, domains 1 and 2 (II1,2)), fibrin (Fibrin I and II), and cellular surface integrin receptors which bind via the cell-binding repeats (I1¡Ý9,II1,2, and III9¡Ý10)
p11
p11
cso30:i:ME_GeneExpression
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c30 : 1
m57739*0.1
nodelay
--
0
PMID:16978691 Collagen was found to stimulate the greatest mRNA expression, followed by FN, while fibrin was found to induce little to no IL-1beta mRNA expression.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1
m18*0.1
nodelay
--
0
PMID:16978691 Collagen was found to stimulate the greatest mRNA expression, followed by FN, while fibrin was found to induce little to no IL-1beta mRNA expression.
p13
p13
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c33 : 1
stoichiometry:c34 : 1
stoichiometry:c35 : 1
m88*m81*0.1
nodelay
--
0
PMID: 16978691,1386877 GM-CSF and TNF-alpha may also further induce the production of IL-1ra
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c36 : 1
stoichiometry:c38 : 1
stoichiometry:c37 : 1
m20*m19*0.1
nodelay
--
0
PMID: 16978691,1386877 GM-CSF and TNF-alpha may also further induce the production of IL-1ra
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c39 : 1
stoichiometry:c40 : 1
stoichiometry:c41 : 1
m230*m21*0.1
nodelay
--
0
PMID: 16978691,1386877 GM-CSF and TNF-alpha may also further induce the production of IL-1ra
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c42 : 1
stoichiometry:c43 : 1
stoichiometry:c44 : 1
m20*m22*0.1
nodelay
--
0
PMID: 16978691,1386877 GM-CSF and TNF-alpha may also further induce the production of IL-1ra
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c46 : 1
stoichiometry:c47 : 1
m23*m24*0.1
nodelay
--
0
PMID: 16978691 Bacteria can bind to the surface receptors of host cells, including macrophages, through bacterial fimbriae.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c48 : 1
stoichiometry:c49 : 1
stoichiometry:c52 : 1
m27*m26*0.1
nodelay
--
0
PMID: 16978691 Beta1 integrin binding with anti-integrin ¦Â1 antibody resulted in an increase in phosphorylation of pp76 and an increase in IL-1beta mRNA expression.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c53 : 1
stoichiometry:c51 : 1
m29*m10*0.1
nodelay
--
0
PMID: 16978691 Beta1 integrin binding with anti-integrin ¦Â1 antibody resulted in an increase in phosphorylation of pp76 and an increase in IL-1beta mRNA expression.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
m6*0.1
nodelay
--
0
PMID: 16978691, The two agonists, IL-1greek alpha and IL-1beta, both initially are synthesized as 31 kDa precursors, pro-IL-1greek small letter alpha and pro-IL-1¦Â, which are then cleaved into their mature 17 kDa forms
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c55 : 1
m28*0.1
nodelay
--
0
PMID: 16978691 Beta1 integrin binding with anti-integrin ¦Â1 antibody resulted in an increase in phosphorylation of pp76 and an increase in IL-1beta mRNA expression.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c57 : 1
m30*0.1
nodelay
--
0
PMID: 16978691 In parallel with the IL-1beta study, anti-beta1 integrin and anti-beta3 integrin antibody pre-treatment also resulted in a general decrease in matrix metalloprotease-2 (MMP-2) and matrix metalloprotease-9 (MMP-9) secretion and mRNA expression.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c59 : 1
m31*0.1
nodelay
--
0
PMID: 16978691 In parallel with the IL-1beta study, anti-beta1 integrin and anti-beta3 integrin antibody pre-treatment also resulted in a general decrease in matrix metalloprotease-2 (MMP-2) and matrix metalloprotease-9 (MMP-9) secretion and mRNA expression.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c62 : 1
m93364*0.1
nodelay
--
0
PMID: 16978691,1386877 GM-CSF and TNF-alpha may also further induce the production of IL-1ra
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c6 : 1
stoichiometry:c7 : 1
stoichiometry:c60 : 1
m1591*m1589*0.1
nodelay
--
0
PMID: 16978691 IL-1 alpha, IL-1beta, and IL-1ra all bind to the biologically active IL-1RI receptor, however IL-1¦Â binds somewhat less efficiently than the other cytokines.
p3
p4
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c8 : 1
stoichiometry:c9 : 1
stoichiometry:c10 : 1
m1592*m1589*0.1
nodelay
--
0
PMID: 16978691 IL-1 alpha, IL-1beta, and IL-1ra all bind to the biologically active IL-1RI receptor, however IL-1¦Â binds somewhat less efficiently than the other cytokines.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c11 : 1
stoichiometry:c12 : 1
stoichiometry:c13 : 1
m1591*m1590*0.1
nodelay
--
0
PMID: 16978691 IL-1RII binds 10?100 times more preferentially to IL-1¦Â than IL-1 alpha or IL-1ra and in soluble form can even bind pro-IL-1beta
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c14 : 1
stoichiometry:c15 : 1
stoichiometry:c16 : 1
m4012*m11*0.1
nodelay
--
0
PMID: 16978691 IL-1RII binds 10?100 times more preferentially to IL-1¦Â than IL-1 alpha or IL-1ra and in soluble form can even bind pro-IL-1beta
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c17 : 1
stoichiometry:c18 : 1
stoichiometry:c19 : 1
m2341*m356124*0.1
nodelay
--
0
PMID: 16978691,12244123,10077553 FN contains multiple binding sites which bind to other molecules such as heparin (heparin I and II), collagen (Type I module, domains 6?9 (I6¡Ý9) and Type II module, domains 1 and 2 (II1,2)), fibrin (Fibrin I and II), and cellular surface integrin receptors which bind via the cell-binding repeats (I1¡Ý9,II1,2, and III9¡Ý10)
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c20 : 1
stoichiometry:c21 : 1
stoichiometry:c22 : 1
m2341*m57739*0.1
nodelay
--
0
PMID: 16978691,12244123,10077553 FN contains multiple binding sites which bind to other molecules such as heparin (heparin I and II), collagen (Type I module, domains 6?9 (I6¡Ý9) and Type II module, domains 1 and 2 (II1,2)), fibrin (Fibrin I and II), and cellular surface integrin receptors which bind via the cell-binding repeats (I1¡Ý9,II1,2, and III9¡Ý10)
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c24 : 1
stoichiometry:c25 : 1
m2341*m2254*0.1
nodelay
--
0
PMID: 16978691,12244123,10077553 FN contains multiple binding sites which bind to other molecules such as heparin (heparin I and II), collagen (Type I module, domains 6?9 (I6¡Ý9) and Type II module, domains 1 and 2 (II1,2)), fibrin (Fibrin I and II), and cellular surface integrin receptors which bind via the cell-binding repeats (I1¡Ý9,II1,2, and III9¡Ý10)
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--