majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:16978691.csml convertedTime:2009.07.01.10:57

Entity

G010279:MMP-9 G010389:IL-1beta G010798:MMP-2 MO000000090:GM-CSFR MO000000099:GM-CSF MO000000289:TNF-alpha MO000016589:IL-1alpha MO000016595:IL-1RI MO000016596:IL-1RII MO000016597:IL-1beta MO000016598:IL-1RA MO000017426:fibrinogen MO000017549:fibronectin MO000018926:heparin MO000019449:proIL-1beta MO000039107:IL-1RI:IL-1RA MO000083632:collagen e1: e10:Beta1-integrin:Beta1-integrin antibody e11:IL-1RII e12:IL-1beta:IL-1RII e13:pro IL-1beta:IL-1RII e14:Fibronectin:Heparin e15:Fibronectin:collagen e16:Fibronectin:Fibrinogen e17:Cellular surface integrin receptors e18:Fibronectin:cellular surface integrin receptors e19:GM-CSF:GM-CSFR e2: e20:IL-1ra e21:TNF-alpha receptor e22:TNF-alpha:receptor e23:Bacteria e24:surface receptor e25:Bacteria:surface receptor e26:Beta1-integrin antibody e27:Beta1-integrin e28:pp76{p} e29:pp76 e3: e30:Anti Beta1-integrin e31:antibet3-integrin antibody e32:IL-1beta:IL-1RI e4: e5:ICE e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:Pro IL-1alpha e60: e61: e62: e7: e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p3 p4 p5 p6 p7 p8 p9
548.0, 687.0
30.0, 30.0

MMP-9

--

G010279

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p22

--

true true true true

csml-variable:Double

m93262

10

false

infinite

0

unit false false false
TRANSFACG010279

--

Go back
506.0, 509.0
25.0, 25.0

IL-1beta

--

G010389

cso30:c:mRNA

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m93364

10

false

infinite

0

unit false false false
TRANSFACG010389

--

Go back
554.0, 613.0
26.0, 26.0

MMP-2

--

G010798

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p21

--

true true true true

csml-variable:Double

m93698

10

false

infinite

0

unit false false false
TRANSFACG010798

--

Go back
1043.0, 242.0
24.0, 24.0

GM-CSFR

--

MO000000090

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13

true true true true

csml-variable:Double

m81

10

false

infinite

0

unit false false false
TRANSPATHMO000000090

--

Go back
1124.0, 231.0
22.0, 22.0

GM-CSF

--

MO000000099

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13

true true true true

csml-variable:Double

m88

10

false

infinite

0

unit false false false
InterProIPR000773
TRANSPATHMO000000099

--

Go back
1124.0, 363.0
22.0, 22.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
128.0, 87.0
22.0, 22.0

IL-1alpha

--

MO000016589

cso30:c:Protein

cso30:i:CC_CellComponent

--

p2

--

true true true true

csml-variable:Double

m1584

10

false

infinite

0

unit false false false
InterProIPR008996
TRANSPATHMO000016589

--

Go back
189.0, 293.0
29.5, 29.5

IL-1RI

--

MO000016595

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3 p4

true true true true

csml-variable:Double

m1589

10

false

infinite

0

unit false false false
InterProIPR004076
TRANSPATHMO000016595

--

Go back
222.0, 137.0
26.0, 26.0

IL-1RII

--

MO000016596

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m1590

10

false

infinite

0

unit false false false
InterProIPR004078
TRANSPATHMO000016596

--

Go back
130.0, 185.0
25.0, 25.0

IL-1beta

--

MO000016597

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m1591

10

false

infinite

0

unit false false false
TRANSPATHMO000016597

--

Go back
128.0, 391.0
22.0, 22.0

IL-1RA

--

MO000016598

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m1592

10

false

infinite

0

unit false false false
InterProIPR003297
TRANSPATHMO000016598

--

Go back
328.0, 43.0
21.0, 21.0

fibrinogen

--

MO000017426

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9

true true true true

csml-variable:Double

m2254

10

false

infinite

0

unit false false false
TRANSPATHMO000017426

--

Go back
457.0, 76.0
19.0, 19.0

fibronectin

--

MO000017549

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7 p8 p9 p10

true true true true

csml-variable:Double

m2341

10

false

infinite

0

unit false false false
InterProIPR006209
TRANSPATHMO000017549

--

Go back
573.0, 36.0
28.0, 28.0

heparin

--

MO000018926

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7

true true true true

csml-variable:Double

m356124

10

false

infinite

0

unit false false false
TRANSPATHMO000018926

--

Go back
103.0, 302.0
24.0, 24.0

proIL-1beta

--

MO000019449

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p6

true true true true

csml-variable:Double

m4012

10

false

infinite

0

unit false false false
InterProIPR003297
TRANSPATHMO000019449

--

Go back
190.0, 337.0
26.0, 26.0

IL-1RI:IL-1RA

--

MO000039107

cso30:c:Protein

cso30:i:CC_CellComponent

--

p4

--

true true true true

csml-variable:Double

m17283

10

false

infinite

0

unit false false false
TRANSPATHMO000039107

--

Go back
725.0, 40.0
19.0, 19.0

collagen

--

MO000083632

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8 p11

true true true true

csml-variable:Double

m57739

10

false

infinite

0

unit false false false
TRANSPATHMO000083632

--

Go back
170.48279587561012, 113.05111189421645
921.0615504569893, 1337.3813712635479

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
1168.5, 630.0
20.233627728711884, 24.775870688218642

Beta1-integrin:Beta1-integrin antibody

--

e10

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false false false

--

Go back
126.0, 441.0
26.0, 26.0

IL-1RII

--

e11

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6

true true true true

csml-variable:Double

m11

10

false

infinite

0

unit false false false
InterProIPR004078
TRANSPATHMO000016596

--

Go back
192.5, 169.0
21.871957903968426, 42.332821749616315

IL-1beta:IL-1RII

--

e12

cso30:c:Complex

cso30:i:CC_Cytosol

--

p5

--

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
116.5, 501.0
20.535744042659555, 25.145809031828023

pro IL-1beta:IL-1RII

--

e13

cso30:c:Complex

cso30:i:CC_Cytosol

--

p6

--

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
621.5, 86.0
19.523246125645723, 23.90601566405599

Fibronectin:Heparin

--

e14

cso30:c:Complex

cso30:i:CC_Cytosol

--

p7

--

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
789.5, 82.0
19.523246125645723, 23.90601566405599

Fibronectin:collagen

--

e15

cso30:c:Complex

cso30:i:CC_Cytosol

--

p8

--

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
321.5, 74.0
19.523246125645723, 23.90601566405599

Fibronectin:Fibrinogen

--

e16

cso30:c:Complex

cso30:i:CC_Cytosol

--

p9

--

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
378.5, 126.0
25.428822495606326, 39.12126537785589

Cellular surface integrin receptors

--

e17

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p10

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
583.5, 116.0
22.673975005481257, 43.885112913834675

Fibronectin:cellular surface integrin receptors

--

e18

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
1048.5, 293.0
21.817583863187895, 42.227581670686256

GM-CSF:GM-CSFR

--

e19

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
170.48279587561012, 113.05111189421645
921.0615504569893, 1337.3813712635479

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
413.0, 558.0
42.6643598615917, 22.75432525951557

IL-1ra

--

e20

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p14 p16

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
1042.5, 370.0
25.405975395430577, 39.086115992970115

TNF-alpha receptor

--

e21

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p15

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
1043.5, 447.0
23.6730980048235, 45.81889936417452

TNF-alpha:receptor

--

e22

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
1111.5, 57.0
23.671463737928423, 34.641166445748915

Bacteria

--

e23

cso30:c:Cell

cso30:i:CC_Cytosol

--

--

p17

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
995.5, 116.0
22.915641476274168, 35.25483304042179

surface receptor

--

e24

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p17

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
1043.5, 167.0
23.6730980048235, 45.81889936417452

Bacteria:surface receptor

--

e25

cso30:c:Complex

cso30:i:CC_Cytosol

--

p17

--

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
1120.0, 530.0
21.384615384615383, 32.07692307692307

Beta1-integrin antibody

--

e26

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p18

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
1168.0, 513.5
22.88, 17.16

Beta1-integrin

--

e27

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p18

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
822.0, 539.0
26.34146341463415, 21.073170731707314

pp76{p}

--

e28

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
829.0, 463.5
24.18595290802978, 14.914670959951701

pp76

--

e29

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p19

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
188.9040268847499, 131.47234290335626
884.2190884387096, 1300.5389092452697

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
1198.0, 701.5
26.99472759226714, 17.54657293497364

Anti Beta1-integrin

--

e30

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p21

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
1183.0, 767.0
24.923076923076923, 37.38461538461538

antibet3-integrin antibody

--

e31

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p22

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
193.5, 235.0
21.871957903968426, 42.332821749616315

IL-1beta:IL-1RI

--

e32

cso30:c:Complex

cso30:i:CC_Cytosol

--

p3

--

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
222.98330425165852, 163.7094971693508
816.0605337048922, 1236.0646007132798

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
87.0, 133.0
15.018709073900842, 34.658559401309624

ICE

--

e5

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p1

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
256.44988171659145, 383.3173374635156
500.8906888806601, 454.252822131996

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
310.54980714504273, 394.08246896831383
292.8858031816152, 440.2614621073963

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
262.9791830614047, 389.38026014084176
487.83208619103453, 442.12697677734286

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
263.9119403963777, 390.3130174758153
485.9665715210876, 440.2614621073963

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
256.44988171659145, 383.3173374635156
500.8906888806601, 454.252822131996

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
256.44988171659145, 383.3173374635156
500.8906888806601, 454.252822131996

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
263.9119403963777, 390.3130174758153
485.9665715210876, 440.2614621073963

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
622.0907570261226, 569.8688044581752
31.292898095333037, 28.32830774945942

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
540.0081115484736, 700.454831354436
88.61194682246314, 80.21713080770361

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
256.44988171659145, 383.3173374635156
500.8906888806601, 454.252822131996

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
123.5, 46.0
14.966794123566109, 24.270476957134246

Pro IL-1alpha

--

e6

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p2

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
374.5069987678459, 585.1835380970037
15.862472135293546, 7.6374865836598715

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
373.97730592322677, 562.4067457783881
54.293516573445636, 97.72832983220223

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
396.7540982418435, 625.9698871326657
8.475085513903705, 8.475085513903718

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
171.48128445966816, 140.95859660444134
887.3773422407295, 1257.3907727691526

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
176.3086920374147, 168.33242674974457
847.0244701767184, 1229.8795306965958

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
165.41668641333058, 162.61142014788757
862.5657717096435, 1241.6889829337028

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
83.0, 238.0
23.0, 23.0

p1

p1

cso30:i:ME_Cleavage

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c3 : 1
stoichiometry:c2 : 1

m4012*m5*0.1

nodelay

--

true

0

false

PMID: 16978691, The two agonists, IL-1greek alpha and IL-1beta, both initially are synthesized as 31 kDa precursors, pro-IL-1greek small letter alpha and pro-IL-1¦Â, which are then cleaved into their mature 17 kDa forms PMID: 16978691 IL-18 is cleaved via the same enzyme, IL-1 converting enzyme (ICE), as IL-1¦Â, although the biological effects can differ.

Go back
456.0, 127.0
21.0, 21.0

p7

p10

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c26 : 1
stoichiometry:c27 : 1
stoichiometry:c28 : 1

m17*m2341*0.1

nodelay

--

true

0

false

PMID: 16978691,12244123,10077553 FN contains multiple binding sites which bind to other molecules such as heparin (heparin I and II), collagen (Type I module, domains 6?9 (I6¡Ý9) and Type II module, domains 1 and 2 (II1,2)), fibrin (Fibrin I and II), and cellular surface integrin receptors which bind via the cell-binding repeats (I1¡Ý9,II1,2, and III9¡Ý10)

Go back
613.0, 449.0
21.0, 21.0

p11

p11

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c30 : 1

m57739*0.1

nodelay

--

true

0

false

PMID:16978691 Collagen was found to stimulate the greatest mRNA expression, followed by FN, while fibrin was found to induce little to no IL-1beta mRNA expression.

Go back
577.0, 433.0
21.0, 21.0

p11

p12

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1

m18*0.1

nodelay

--

true

0

false

PMID:16978691 Collagen was found to stimulate the greatest mRNA expression, followed by FN, while fibrin was found to induce little to no IL-1beta mRNA expression.

Go back
1124.0, 303.0
21.0, 21.0

p13

p13

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c33 : 1
stoichiometry:c34 : 1
stoichiometry:c35 : 1

m88*m81*0.1

nodelay

--

true

0

false

PMID: 16978691,1386877 GM-CSF and TNF-alpha may also further induce the production of IL-1ra

Go back
315.0, 350.0
23.0, 23.0

p14

p14

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c36 : 1
stoichiometry:c38 : 1
stoichiometry:c37 : 1

m20*m19*0.1

nodelay

--

true

0

false

PMID: 16978691,1386877 GM-CSF and TNF-alpha may also further induce the production of IL-1ra

Go back
1124.0, 419.0
21.0, 21.0

p13

p15

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c39 : 1
stoichiometry:c40 : 1
stoichiometry:c41 : 1

m230*m21*0.1

nodelay

--

true

0

false

PMID: 16978691,1386877 GM-CSF and TNF-alpha may also further induce the production of IL-1ra

Go back
372.0, 300.0
23.0, 23.0

p14

p16

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c42 : 1
stoichiometry:c43 : 1
stoichiometry:c44 : 1

m20*m22*0.1

nodelay

--

true

0

false

PMID: 16978691,1386877 GM-CSF and TNF-alpha may also further induce the production of IL-1ra

Go back
1112.0, 127.0
19.0, 19.0

p17

p17

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c46 : 1
stoichiometry:c47 : 1

m23*m24*0.1

nodelay

--

true

0

false

PMID: 16978691 Bacteria can bind to the surface receptors of host cells, including macrophages, through bacterial fimbriae.

Go back
1168.0, 571.0
21.0, 21.0

p18

p18

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c48 : 1
stoichiometry:c49 : 1
stoichiometry:c52 : 1

m27*m26*0.1

nodelay

--

true

0

false

PMID: 16978691 Beta1 integrin binding with anti-integrin ¦Â1 antibody resulted in an increase in phosphorylation of pp76 and an increase in IL-1beta mRNA expression.

Go back
876.0, 499.0
23.0, 23.0

p19

p19

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c53 : 1
stoichiometry:c51 : 1

m29*m10*0.1

nodelay

--

true

0

false

PMID: 16978691 Beta1 integrin binding with anti-integrin ¦Â1 antibody resulted in an increase in phosphorylation of pp76 and an increase in IL-1beta mRNA expression.

Go back
180.0, 47.0
22.0, 22.0

p1

p2

cso30:i:ME_Cleavage

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1

m6*0.1

nodelay

--

true

0

false

PMID: 16978691, The two agonists, IL-1greek alpha and IL-1beta, both initially are synthesized as 31 kDa precursors, pro-IL-1greek small letter alpha and pro-IL-1¦Â, which are then cleaved into their mature 17 kDa forms

Go back
607.0, 546.0
23.0, 23.0

p20

p20

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c55 : 1

m28*0.1

nodelay

--

true

0

false

PMID: 16978691 Beta1 integrin binding with anti-integrin ¦Â1 antibody resulted in an increase in phosphorylation of pp76 and an increase in IL-1beta mRNA expression.

Go back
637.0, 616.0
19.0, 19.0

p21

p21

cso30:i:ME_GeneExpression

cso30:i:CC_Cytoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c57 : 1

m30*0.1

nodelay

--

true

0

false

PMID: 16978691 In parallel with the IL-1beta study, anti-beta1 integrin and anti-beta3 integrin antibody pre-treatment also resulted in a general decrease in matrix metalloprotease-2 (MMP-2) and matrix metalloprotease-9 (MMP-9) secretion and mRNA expression.

Go back
629.0, 692.0
19.0, 19.0

p21

p22

cso30:i:ME_GeneExpression

cso30:i:CC_Cytoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c59 : 1

m31*0.1

nodelay

--

true

0

false

PMID: 16978691 In parallel with the IL-1beta study, anti-beta1 integrin and anti-beta3 integrin antibody pre-treatment also resulted in a general decrease in matrix metalloprotease-2 (MMP-2) and matrix metalloprotease-9 (MMP-9) secretion and mRNA expression.

Go back
408.0, 240.0
23.0, 23.0

p14

p23

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c62 : 1

m93364*0.1

nodelay

--

true

0

false

PMID: 16978691,1386877 GM-CSF and TNF-alpha may also further induce the production of IL-1ra

Go back
132.0, 247.0
22.0, 22.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c6 : 1
stoichiometry:c7 : 1
stoichiometry:c60 : 1

m1591*m1589*0.1

nodelay

--

true

0

false

PMID: 16978691 IL-1 alpha, IL-1beta, and IL-1ra all bind to the biologically active IL-1RI receptor, however IL-1¦Â binds somewhat less efficiently than the other cytokines.

Go back
128.0, 339.0
22.0, 22.0

p3

p4

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c8 : 1
stoichiometry:c9 : 1
stoichiometry:c10 : 1

m1592*m1589*0.1

nodelay

--

true

0

false

PMID: 16978691 IL-1 alpha, IL-1beta, and IL-1ra all bind to the biologically active IL-1RI receptor, however IL-1¦Â binds somewhat less efficiently than the other cytokines.

Go back
132.0, 119.0
21.0, 21.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c11 : 1
stoichiometry:c12 : 1
stoichiometry:c13 : 1

m1591*m1590*0.1

nodelay

--

true

0

false

PMID: 16978691 IL-1RII binds 10?100 times more preferentially to IL-1¦Â than IL-1 alpha or IL-1ra and in soluble form can even bind pro-IL-1beta

Go back
72.0, 363.0
21.0, 21.0

p5

p6

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c14 : 1
stoichiometry:c15 : 1
stoichiometry:c16 : 1

m4012*m11*0.1

nodelay

--

true

0

false

PMID: 16978691 IL-1RII binds 10?100 times more preferentially to IL-1¦Â than IL-1 alpha or IL-1ra and in soluble form can even bind pro-IL-1beta

Go back
504.0, 39.0
21.0, 21.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c17 : 1
stoichiometry:c18 : 1
stoichiometry:c19 : 1

m2341*m356124*0.1

nodelay

--

true

0

false

PMID: 16978691,12244123,10077553 FN contains multiple binding sites which bind to other molecules such as heparin (heparin I and II), collagen (Type I module, domains 6?9 (I6¡Ý9) and Type II module, domains 1 and 2 (II1,2)), fibrin (Fibrin I and II), and cellular surface integrin receptors which bind via the cell-binding repeats (I1¡Ý9,II1,2, and III9¡Ý10)

Go back
640.0, 55.0
21.0, 21.0

p7

p8

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c20 : 1
stoichiometry:c21 : 1
stoichiometry:c22 : 1

m2341*m57739*0.1

nodelay

--

true

0

false

PMID: 16978691,12244123,10077553 FN contains multiple binding sites which bind to other molecules such as heparin (heparin I and II), collagen (Type I module, domains 6?9 (I6¡Ý9) and Type II module, domains 1 and 2 (II1,2)), fibrin (Fibrin I and II), and cellular surface integrin receptors which bind via the cell-binding repeats (I1¡Ý9,II1,2, and III9¡Ý10)

Go back
392.0, 75.0
21.0, 21.0

p7

p9

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c24 : 1
stoichiometry:c25 : 1

m2341*m2254*0.1

nodelay

--

true

0

false

PMID: 16978691,12244123,10077553 FN contains multiple binding sites which bind to other molecules such as heparin (heparin I and II), collagen (Type I module, domains 6?9 (I6¡Ý9) and Type II module, domains 1 and 2 (II1,2)), fibrin (Fibrin I and II), and cellular surface integrin receptors which bind via the cell-binding repeats (I1¡Ý9,II1,2, and III9¡Ý10)

Go back
100.41795088587145, 268.62584510159456

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
150.0, 350.0

c10

c10

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
143.0, 148.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
160.8174109113824, 133.69943715464834

c12

c12

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
153.0, 140.0

c13

c13

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
92.80413627492379, 326.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
94.59540599277145, 390.5484535396993

c15

c15

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
86.0, 384.0

c16

c16

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
476.0, 62.8

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
533.0, 50.0

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
525.0, 54.0

c19

c19

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
106.0, 215.8623479330104

c2

c2

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
476.0, 67.87280742401299

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
668.8629774954745, 52.0

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
661.0, 68.0

c22

c22

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
421.0, 86.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
349.0, 59.0

c24

c24

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
349.0, 86.0

c25

c25

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
404.0, 139.91699286388103

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
467.0, 95.0

c27

c27

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
477.0, 138.0

c28

c28

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
629.0982387070455, 59.0

c29

c29

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
95.0, 168.0

c3

c3

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
537.8673218643836, 466.0

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
588.1757817267227, 160.0

c31

c31

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
535.321648337188, 454.0

c32

c32

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1135.0, 253.0

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1067.0, 263.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1078.0, 314.0

c35

c35

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
336.654437479941, 380.1165361451483

c36

c36

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
157.82587300081954, 365.0

c37

c37

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
345.9833092571598, 315.0

c38

c38

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1135.0, 385.0

c39

c39

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
138.0, 58.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1068.0, 397.0

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1074.1302242460888, 435.0

c41

c41

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
387.53679234081966, 330.85100434983946

c42

c42

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
402.78922203006647, 316.8242862073499

c43

c43

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
157.50443377014824, 316.0

c44

c44

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1122.228478191191, 92.0

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1018.0, 134.0

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1073.3148177390106, 145.0

c47

c47

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1179.0, 531.0

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1141.0, 554.0

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
156.3488508903353, 67.0

c5

c5

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
850.0, 478.0

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
854.5098677696539, 520.0

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1179.0, 592.0

c52

c52

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
906.3004225764489, 519.2716708583345

c53

c53

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
637.9946884542561, 551.0

c54

c54

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
538.5067449345369, 528.7656428706189

c55

c55

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
663.912132119669, 628.182440409028

c56

c56

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
588.0, 626.0

c57

c57

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
655.9098567032398, 704.1975670896494

c58

c58

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
586.0, 702.0

c59

c59

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
143.0, 210.0

c6

c6

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
154.0, 256.39950093555115

c60

c60

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
426.74865225010825, 270.51298281696256

c61

c61

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
162.8482042878889, 201.55102851539306

c62

c62

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
160.1601724872445, 272.1041429180026

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
139.0, 369.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
156.735033111711, 318.0

c9

c9

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back