Entity
NF-kappaB
--
MO000000058
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m46
10
infinite
0
TRANSPATH | MO000000058 |
--
TRAF6
--
MO000000212
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m183
10
infinite
0
InterPro | IPR001841 |
TRANSPATH | MO000000212 |
--
AP-1
--
MO000000276
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m219
10
infinite
0
TRANSPATH | MO000000276 |
--
TNF-alpha
--
MO000000289
cso30:c:Protein
cso30:i:CC_CellComponent
--
--
csml-variable:Double
m230
10
infinite
0
InterPro | IPR003636 |
TRANSPATH | MO000000289 |
--
IRAK-M
--
MO000016569
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m1571
10
infinite
0
InterPro | IPR000719 |
TRANSPATH | MO000016569 |
--
TLR2
--
MO000019397
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m3964
10
infinite
0
InterPro | IPR000157 |
TRANSPATH | MO000019397 |
--
IRAK-4
--
MO000039077
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m17258
10
infinite
0
TRANSPATH | MO000039077 |
--
--
e1
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane
--
--
--
csml-variable:Double
m1
0
infinite
0
--
--
e10
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytosol
--
--
--
csml-variable:Double
m10
0
infinite
0
--
LPS:CD14
--
e11
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m11
0
infinite
0
--
BLP
--
e12
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m12
0
infinite
0
--
BLP:CD14
--
e13
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m13
0
infinite
0
--
csml-variable:Double
m14
0
infinite
0
--
LTA:CD14
--
e15
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m15
0
infinite
0
--
LPS:TLR4
--
e16
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m16
0
infinite
0
--
LPS:TLR4:MYD88
--
e17
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m17
0
infinite
0
--
LPS:TLR4:MYD88:IRAK
--
e18
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
csml-variable:Double
m18
0
infinite
0
--
LPS:TLR4:MYD88:IRAK:TRAF6
--
e19
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m19
0
infinite
0
--
--
e2
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m2
0
infinite
0
--
NF-kappaB:IkappaB
--
e21
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m21
0
infinite
0
--
AP-1{active}
--
e26
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m29
10
infinite
0
TRANSPATH | MO000000276 |
--
csml-variable:Double
m30
0
infinite
0
--
TLR2:LAM
--
e28
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m31
0
infinite
0
--
STF
--
e29
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m32
0
infinite
0
--
--
e3
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
--
csml-variable:Double
m3
0
infinite
0
--
STF:TLR2
--
e30
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m33
0
infinite
0
--
csml-variable:Double
m34
0
infinite
0
--
LPS:TLR4:MYD88:IRAK1:TRAF6
--
e32
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m35
0
infinite
0
--
IRAK2:TRAF6
--
e33
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m36
0
infinite
0
--
IRAK4:TRAF6
--
e34
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m37
0
infinite
0
--
IRAKM:TRAF6
--
e35
cso30:c:Complex
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m38
0
infinite
0
--
IRAK1:TRAF6
--
e36
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m39
0
infinite
0
--
protein remnants
--
e37
cso30:c:EntityBiological
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m40
0
infinite
0
--
LPS:TLR4:MYD88:IRAK1
--
e38
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m41
0
infinite
0
--
LPS:TLR4:MYD88:IRAK1{p}:TRAF6
--
e39
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m42
0
infinite
0
--
--
e4
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m4
0
infinite
0
--
LPS:TLR4:MYD88
--
e40
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m43
0
infinite
0
--
IRAK1:TRAF6:TAK1:TAB2
--
e41
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m44
0
infinite
0
--
NF-kappaB:IkappaB{p}
--
e42
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m22
0
infinite
0
--
NF-kappaB:IkappaB{p}{ub}
--
e43
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m45
0
infinite
0
--
MALP2
--
e5
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m5
0
infinite
0
--
--
e50
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelopeLumen
--
--
--
csml-variable:Double
m50
0
infinite
0
--
--
e51
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearPore
--
--
--
csml-variable:Double
m51
0
infinite
0
--
--
e52
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearInnerMembrane
--
--
--
csml-variable:Double
m52
0
infinite
0
--
--
e53
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearLumen
--
--
--
csml-variable:Double
m53
0
infinite
0
--
--
e54
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearOuterMembrane
--
--
--
csml-variable:Double
m54
0
infinite
0
--
--
e55
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleus
--
--
--
csml-variable:Double
m55
0
infinite
0
--
--
e56
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleoplasm
--
--
--
csml-variable:Double
m56
0
infinite
0
--
--
e57
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearBody
--
--
--
csml-variable:Double
m57
0
infinite
0
--
--
e58
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleolus
--
--
--
csml-variable:Double
m58
0
infinite
0
--
--
e59
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelope
--
--
--
csml-variable:Double
m59
0
infinite
0
--
TLR2:MALP2
--
e6
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m6
0
infinite
0
--
--
e60
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Chromatin
--
--
--
csml-variable:Double
m60
0
infinite
0
--
--
e61
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearChromosome
--
--
--
csml-variable:Double
m61
0
infinite
0
--
--
e62
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearCentromere
--
--
--
csml-variable:Double
m62
0
infinite
0
--
--
e7
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell
--
--
--
csml-variable:Double
m7
0
infinite
0
--
--
e8
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell_WithoutCellWall_
--
--
--
csml-variable:Double
m8
0
infinite
0
--
--
e9
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytoplasm
--
--
--
csml-variable:Double
m9
0
infinite
0
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1
m3964*m5*0.1
nodelay
--
0
PMID: 16885502 MALP-2 was found to induce self-tolerance as measured by TNF-{alpha} production but also, to induce cross-tolerance to LPS.
p10
p10
cso30:i:ME_Binding
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c29 : 1
stoichiometry:c89 : 1
stoichiometry:c30 : 1
m18*m183*0.1
nodelay
--
0
PMID: 16885502, 10754329, 10215628 After ligand binding, TLRs sequentially recruit the adaptor molecules MyD88, IL-1R-associated kinase (IRAK)and TNF receptor-associated factor 6 (TRAF6). PMID: 16885502 IRAK-M prevents dissociation of IRAK-1 and IRAK-4 from MyD88 and inhibits formation of the IRAK-TRAF-6 complex.
p11
p11
cso30:i:ME_Binding
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c90 : 1
stoichiometry:c91 : 1
stoichiometry:c108 : 1
stoichiometry:c92 : 1
m34*m17*0.1
nodelay
--
0
PMID: 16885502, 10754329, 10215628 After ligand binding, TLRs sequentially recruit the adaptor molecules MyD88, IL-1R-associated kinase (IRAK)and TNF receptor-associated factor 6 (TRAF6). PMID: 16885502 IRAK-M prevents dissociation of IRAK-1 and IRAK-4 from MyD88 and inhibits formation of the IRAK-TRAF-6 complex.
p12
p12
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c36 : 1
stoichiometry:c32 : 1
m207*m44*0.1
nodelay
--
0
PMID: 16885502 TAK-1 phosphorylates the MAPKs and the IKK complex, a cytoplasmic inhibitor of NF-{kappa}B
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c33 : 1
stoichiometry:c35 : 1
stoichiometry:c34 : 1
m21*m20*0.1
nodelay
--
0
PMID: 16885502, 10602462 Activation of IKK complex results in phosphorylation of I{kappa}B{alpha} and I{kappa}Bbeta, ubiquitination, and degradation of I{kappa}B, and release of the active NF-{kappa}B complex.
p14
p14
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c39 : 1
stoichiometry:c38 : 1
m23*m44*0.1
nodelay
--
0
PMID: 16885502 TAK-1 phosphorylates the MAPKs and the IKK complex, a cytoplasmic inhibitor of NF-{kappa}B. PMID: 16885502, 11303728 Three major MAPKs, ERK1/2, JNK, and p38, are phosphorylated and activated following LPS stimulation.
p15
p15
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c103 : 1
stoichiometry:c41 : 1
m25*m44*0.1
nodelay
--
0
PMID: 16885502 TAK-1 phosphorylates the MAPKs and the IKK complex, a cytoplasmic inhibitor of NF-{kappa}B. PMID: 16885502, 11303728 Three major MAPKs, ERK1/2, JNK, and p38, are phosphorylated and activated following LPS stimulation.
p16
p16
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c105 : 1
stoichiometry:c44 : 1
m549*m44*0.1
nodelay
--
0
PMID: 16885502 TAK-1 phosphorylates the MAPKs and the IKK complex, a cytoplasmic inhibitor of NF-{kappa}B. PMID: 16885502, 11303728 Three major MAPKs, ERK1/2, JNK, and p38, are phosphorylated and activated following LPS stimulation.
p17
p17
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c104 : 1
stoichiometry:c46 : 1
m554*m44*0.1
nodelay
--
0
PMID: 16885502 TAK-1 phosphorylates the MAPKs and the IKK complex, a cytoplasmic inhibitor of NF-{kappa}B. PMID: 16885502, 11303728 Three major MAPKs, ERK1/2, JNK, and p38, are phosphorylated and activated following LPS stimulation.
p18
p18
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c51 : 1
stoichiometry:c50 : 1
m219*m27*0.1
nodelay
--
0
PMID: 16885502, 11357875 In turn, these adaptor molecules activate the I{kappa}B kinase (IKK) complex and MAPKs, JNK, p38, and ERK1/2, leading to the activation of NF-{kappa}B and AP-1, respectively, and ultimately, to transcription of inflammatory target genes.
p19
p19
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c54 : 1
stoichiometry:c53 : 1
m219*m24*0.1
nodelay
--
0
PMID: 16885502, 11357875 In turn, these adaptor molecules activate the I{kappa}B kinase (IKK) complex and MAPKs, JNK, p38, and ERK1/2, leading to the activation of NF-{kappa}B and AP-1, respectively, and ultimately, to transcription of inflammatory target genes.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c5 : 1
stoichiometry:c4 : 1
m6*0.1
nodelay
--
0
PMID: 16885502 MALP-2 was found to induce self-tolerance as measured by TNF-{alpha} production but also, to induce cross-tolerance to LPS.
p20
p20
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c57 : 1
stoichiometry:c56 : 1
m219*m26*0.1
nodelay
--
0
PMID: 16885502, 11357875 In turn, these adaptor molecules activate the I{kappa}B kinase (IKK) complex and MAPKs, JNK, p38, and ERK1/2, leading to the activation of NF-{kappa}B and AP-1, respectively, and ultimately, to transcription of inflammatory target genes.
p21
p21
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c60 : 1
stoichiometry:c59 : 1
m219*m28*0.1
nodelay
--
0
PMID: 16885502, 11357875 In turn, these adaptor molecules activate the I{kappa}B kinase (IKK) complex and MAPKs, JNK, p38, and ERK1/2, leading to the activation of NF-{kappa}B and AP-1, respectively, and ultimately, to transcription of inflammatory target genes.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c62 : 1
stoichiometry:c63 : 1
m3964*m30*0.1
nodelay
--
0
PMID: 16885502 The mycobacterial components, lipoarabinomannan (LAM) and soluble tuberculosis factor (STF), activated cells expressing TLR2.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c64 : 1
stoichiometry:c65 : 1
stoichiometry:c66 : 1
m3964*m32*0.1
nodelay
--
0
PMID: 16885502 The mycobacterial components, lipoarabinomannan (LAM) and soluble tuberculosis factor (STF), activated cells expressing TLR2.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c68 : 1
stoichiometry:c69 : 1
m183*m41*0.1
nodelay
--
0
PMID: 16885502, 10383454, 9734363, 11960013 IRAKs bind to TRAF6.
p25
p25
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1
stoichiometry:c71 : 1
stoichiometry:c72 : 1
m1569*m183*0.1
nodelay
--
0
PMID: 16885502, 10383454, 9734363, 11960013 IRAKs bind to TRAF6.
p26
p26
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c74 : 1
stoichiometry:c75 : 1
m183*m17258*0.1
nodelay
--
0
PMID: 16885502, 10383454, 9734363, 11960013 IRAKs bind to TRAF6.
p27
p27
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c77 : 1
stoichiometry:c78 : 1
m1571*m183*0.1
nodelay
--
0
PMID: 16885502, 10383454, 9734363, 11960013 IRAKs bind to TRAF6.
p28
p28
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c95 : 1
stoichiometry:c96 : 1
stoichiometry:c97 : 1
stoichiometry:c98 : 1
m39*m1573*m6432*0.1
nodelay
--
0
PMID: 16885502, 14751757 Following phosphorylation of IRAK-1, IRAK-1 and TRAF-6 dissociate from the receptor complex, and TRAF-6 interacts with TGF-?-activated kinase-1 (TAK-1), TAK-1/2-binding protein, resulting in activation of TAK-1.
p29
p29
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c88 : 1
stoichiometry:c93 : 1
stoichiometry:c82 : 1
m17258*m35*0.1
nodelay
--
0
PMID: 16885502, 12055225 LPS causes IRAK-1 activation, phosphorylation, and subsequent degradation. PMID: 16885502, 11960013 IRAK-4 has been demonstrated to act upstream of IRAK-1 and is responsible for phosphorylation of IRAK-1.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c6 : 1
m93309*m6*0.1
nodelay
--
0
PMID: 16885502 MALP-2 was found to induce self-tolerance as measured by TNF-{alpha} production but also, to induce cross-tolerance to LPS.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c81 : 1
stoichiometry:c80 : 1
m94019*0.1
nodelay
--
0
PMID: 16885502 When cells were pretreated with BLP for 24 h, there was a marked decrease in IRAK-1 protein levels compared with na?ve cells.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c107 : 1
m46*0.1
nodelay
--
0
PMID: 16885502 Following activation, NF-{kappa}B is translocated to the nucleus, where it activates the transcription of proinflammatory genes.
p32
p32
cso30:i:ME_Dissociation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c109 : 1
stoichiometry:c85 : 1
stoichiometry:c94 : 1
m42*0.1
nodelay
--
0
PMID: 16885502, 14751757 Following phosphorylation of IRAK-1, IRAK-1 and TRAF-6 dissociate from the receptor complex, and TRAF-6 interacts with TGF-?-activated kinase-1 (TAK-1), TAK-1/2-binding protein, resulting in activation of TAK-1. PMID: 16885502 IRAK-M prevents dissociation of IRAK-1 and IRAK-4 from MyD88 and inhibits formation of the IRAK-TRAF-6 complex.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c100 : 1
m22*0.1
nodelay
--
0
PMID: 16885502, 10602462 Activation of IKK complex results in phosphorylation of I{kappa}B{alpha} and I{kappa}Bbeta, ubiquitination, and degradation of I{kappa}B, and release of the active NF-{kappa}B complex.
p34
p34
cso30:i:ME_UnknownDegradation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c101 : 1
stoichiometry:c86 : 1
stoichiometry:c87 : 1
m45*0.1
nodelay
--
0
PMID: 16885502, 10602462 Activation of IKK complex results in phosphorylation of I{kappa}B{alpha} and I{kappa}Bbeta, ubiquitination, and degradation of I{kappa}B, and release of the active NF-{kappa}B complex.
p35
p35
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c110 : 1
stoichiometry:c112 : 1
stoichiometry:c111 : 1
m554*m13*0.1
nodelay
--
0
PMID: 16885502, 12133836 BLP stimulation of THP-1 monocytes induces activation of ERK1/2, JNK, and p38.
p36
p36
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c113 : 1
stoichiometry:c115 : 1
stoichiometry:c114 : 1
m549*m13*0.1
nodelay
--
0
PMID: 16885502, 12133836 BLP stimulation of THP-1 monocytes induces activation of ERK1/2, JNK, and p38.
p37
p37
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c116 : 1
stoichiometry:c118 : 1
stoichiometry:c117 : 1
m25*m13*0.1
nodelay
--
0
PMID: 16885502, 12133836 BLP stimulation of THP-1 monocytes induces activation of ERK1/2, JNK, and p38.
p38
p38
cso30:i:ME_Phosphorylation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c119 : 1
stoichiometry:c121 : 1
stoichiometry:c120 : 1
m23*m13*0.1
nodelay
--
0
PMID: 16885502, 12133836 BLP stimulation of THP-1 monocytes induces activation of ERK1/2, JNK, and p38.
p4
p4
cso30:i:ME_Binding
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c9 : 1
stoichiometry:c10 : 1
stoichiometry:c11 : 1
m2828*m155666*0.1
nodelay
--
0
PMID: 16885502, 1698311 CD14 recognizes and binds LPS with high-affinity.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c12 : 1
stoichiometry:c13 : 1
stoichiometry:c14 : 1
m2828*m12*0.1
nodelay
--
0
PMID: 16885502, 9605151, 10452971, 8675286 CD14 has also been implicated in activation of the inflammatory response to gram-positive bacterial components such as BLP and LTA.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c16 : 1
stoichiometry:c17 : 1
m14*m2828*0.1
nodelay
--
0
PMID: 16885502, 9605151, 10452971, 8675286 CD14 has also been implicated in activation of the inflammatory response to gram-positive bacterial components such as BLP and LTA.
p7
p7
cso30:i:ME_Binding
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c18 : 1
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1
m11*m3961*0.1
nodelay
--
0
PMID: 16885502, 11067937, 10725698 Multiple studies have confirmed that LPS signals primarily through TLR4.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1
m16*m1572*0.1
nodelay
--
0
PMID: 16885502, 10754329, 10215628 After ligand binding, TLRs sequentially recruit the adaptor molecules MyD88, IL-1R-associated kinase (IRAK)and TNF receptor-associated factor 6 (TRAF6).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1
m17*m184*0.1
nodelay
--
0
PMID: 16885502, 10754329, 10215628 After ligand binding, TLRs sequentially recruit the adaptor molecules MyD88, IL-1R-associated kinase (IRAK)and TNF receptor-associated factor 6 (TRAF6).
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--