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PMID: 16713969
Figure1
PMID: 16713969
Viral PAMPs trigger multiple signaling cascades through Toll-like-receptor-dependent (TLR3, TLR7, and TLR9) and -independent (RIG-I and MDA5) pathways leading to kinase activation through TRAF family members
PMID: 16713969
Figure1
PMID: 16713969
TRIF and MyD88 are the adaptors linking TLRs to the TRAF proteins, whereas MAVS links RIG-1 and MDA5 to TRAF3.
PMID: 16713969
TRIF and MyD88 are the adaptors linking TLRs to the TRAF proteins, whereas MAVS links RIG-1 and MDA5 to TRAF3.
PMID: 16713969
TRIF and MyD88 are the adaptors linking TLRs to the TRAF proteins, whereas MAVS links RIG-1 and MDA5 to TRAF3.
indirect
PMID: 16713969
Figure 1
PMID: 16713969
TRAF-dependent induction of the kinases JNK, IKK-alpha, IKK-beta, IKK-gamma, TBK1, and IRAK1 induce the binding of the transcription factors ATF2-cJun complex, NF-KappaB (p50-p65 complex), IRF3, and IRF7 to sequence specific positive regulatory domains (PRD) located upstream of the interferon-beta start site.
indirect
PMID: 16713969
Figure 1
PMID: 16713969
TRAF-dependent induction of the kinases JNK, IKK-alpha, IKK-beta, IKK-gamma, TBK1, and IRAK1 induce the binding of the transcription factors ATF2-cJun complex, NF-KappaB (p50-p65 complex), IRF3, and IRF7 to sequence specific positive regulatory domains (PRD) located upstream of the interferon-beta start site.
PMID: 16713969
Figure 1
PMID: 16713969
Viral PAMPs trigger multiple signaling cascades through Toll-like-receptor-dependent (TLR3, TLR7, and TLR9) and -independent (RIG-I and MDA5) pathways leading to kinase activation through TRAF family members
PMID: 16713969
Figure 1
PMID: 16713969
Viral PAMPs trigger multiple signaling cascades through Toll-like-receptor-dependent (TLR3, TLR7, and TLR9) and -independent (RIG-I and MDA5) pathways leading to kinase activation through TRAF family members
PMID: 16713969
Figure1
PMID: 16713969
TRIF and MyD88 are the adaptors linking TLRs to the TRAF proteins, whereas MAVS links RIG-1 and MDA5 to TRAF3.
PMID: 16713969
Figure1
PMID: 16713969
TRIF and MyD88 are the adaptors linking TLRs to the TRAF proteins, whereas MAVS links RIG-1 and MDA5 to TRAF3.
PMID: 16713969
Figure1
PMID: 16713969
TRIF and MyD88 are the adaptors linking TLRs to the TRAF proteins, whereas MAVS links RIG-1 and MDA5 to TRAF3.
PMID: 16713969
Figure1
PMID: 16713969
TRIF and MyD88 are the adaptors linking TLRs to the TRAF proteins, whereas MAVS links RIG-1 and MDA5 to TRAF3.
indirect
PMID: 16713969
Figure 1
PMID: 16713969
TRAF-dependent induction of the kinases JNK, IKK-alpha, IKK-beta, IKK-gamma, TBK1, and IRAK1 induce the binding of the transcription factors ATF2-cJun complex, NF-KappaB (p50-p65 complex), IRF3, and IRF7 to sequence specific positive regulatory domains (PRD) located upstream of the interferon-beta start site.
indirect
PMID: 16713969
Figure 1
PMID: 16713969
TRAF-dependent induction of the kinases JNK, IKK-alpha, IKK-beta, IKK-gamma, TBK1, and IRAK1 induce the binding of the transcription factors ATF2-cJun complex, NF-KappaB (p50-p65 complex), IRF3, and IRF7 to sequence specific positive regulatory domains (PRD) located upstream of the interferon-beta start site.
indirect
PMID: 16713969
Figure 1
PMID: 16713969
TRAF-dependent induction of the kinases JNK, IKK-alpha, IKK-beta, IKK-gamma, TBK1, and IRAK1 induce the binding of the transcription factors ATF2-cJun complex, NF-KappaB (p50-p65 complex), IRF3, and IRF7 to sequence specific positive regulatory domains (PRD) located upstream of the interferon-beta start site.
indirect
PMID: 16713969
Figure 1
PMID: 16713969
TRAF-dependent induction of the kinases JNK, IKK-alpha, IKK-beta, IKK-gamma, TBK1, and IRAK1 induce the binding of the transcription factors ATF2-cJun complex, NF-KappaB (p50-p65 complex), IRF3, and IRF7 to sequence specific positive regulatory domains (PRD) located upstream of the interferon-beta start site.
indirect
PMID: 16713969
Figure 1
PMID: 16713969
TRAF-dependent induction of the kinases JNK, IKK-alpha, IKK-beta, IKK-gamma, TBK1, and IRAK1 induce the binding of the transcription factors ATF2-cJun complex, NF-KappaB (p50-p65 complex), IRF3, and IRF7 to sequence specific positive regulatory domains (PRD) located upstream of the interferon-beta start site.
indirect
PMID: 16713969
Figure 1
PMID: 16713969
TRAF-dependent induction of the kinases JNK, IKK-alpha, IKK-beta, IKK-gamma, TBK1, and IRAK1 induce the binding of the transcription factors ATF2-cJun complex, NF-KappaB (p50-p65 complex), IRF3, and IRF7 to sequence specific positive regulatory domains (PRD) located upstream of the interferon-beta start site.
PMID: 16713969
Figure 1
PMID: 16713969
Viral PAMPs trigger multiple signaling cascades through Toll-like-receptor-dependent (TLR3, TLR7, and TLR9) and -independent (RIG-I and MDA5) pathways leading to kinase activation through TRAF family members
PMID: 16713969
Figure 1
PMID: 16713969
Viral PAMPs trigger multiple signaling cascades through Toll-like-receptor-dependent (TLR3, TLR7, and TLR9) and -independent (RIG-I and MDA5) pathways leading to kinase activation through TRAF family members
PMID: 16713969
TRIF and MyD88 are the adaptors linking TLRs to the TRAF proteins, whereas MAVS links RIG-1 and MDA5 to TRAF3.
indirect
PMID: 16713969
TRIF and MyD88 are the adaptors linking TLRs to the TRAF proteins, whereas MAVS links RIG-1 and MDA5 to TRAF3.
PMID: 16713969
TRIF and MyD88 are the adaptors linking TLRs to the TRAF proteins, whereas MAVS links RIG-1 and MDA5 to TRAF3.
PMID: 16713969
TRIF and MyD88 are the adaptors linking TLRs to the TRAF proteins, whereas MAVS links RIG-1 and MDA5 to TRAF3.
indirect
PMID: 16713969
Figure 1
PMID: 16713969
TRAF-dependent induction of the kinases JNK, IKK-alpha, IKK-beta, IKK-gamma, TBK1, and IRAK1 induce the binding of the transcription factors ATF2-cJun complex, NF-KappaB (p50-p65 complex), IRF3, and IRF7 to sequence specific positive regulatory domains (PRD) located upstream of the interferon-beta start site.
indirect
PMID: 16713969
Figure 1
PMID: 16713969
TRAF-dependent induction of the kinases JNK, IKK-alpha, IKK-beta, IKK-gamma, TBK1, and IRAK1 induce the binding of the transcription factors ATF2-cJun complex, NF-KappaB (p50-p65 complex), IRF3, and IRF7 to sequence specific positive regulatory domains (PRD) located upstream of the interferon-beta start site.
PMID: 16713969
Figure 1
PMID: 16713969
TRAF-dependent induction of the kinases JNK, IKK-alpha, IKK-beta, IKK-gamma, TBK1, and IRAK1 induce the binding of the transcription factors ATF2-cJun complex, NF-KappaB (p50-p65 complex), IRF3, and IRF7 to sequence specific positive regulatory domains (PRD) located upstream of the interferon-beta start site.
indirect
PMID: 16713969
Figure 1
PMID: 16713969
TRAF-dependent induction of the kinases JNK, IKK-alpha, IKK-beta, IKK-gamma, TBK1, and IRAK1 induce the binding of the transcription factors ATF2-cJun complex, NF-KappaB (p50-p65 complex), IRF3, and IRF7 to sequence specific positive regulatory domains (PRD) located upstream of the interferon-beta start site.
indirect
PMID: 16713969
Figure 1
PMID: 16713969
TRAF-dependent induction of the kinases JNK, IKK-alpha, IKK-beta, IKK-gamma, TBK1, and IRAK1 induce the binding of the transcription factors ATF2-cJun complex, NF-KappaB (p50-p65 complex), IRF3, and IRF7 to sequence specific positive regulatory domains (PRD) located upstream of the interferon-beta start site.
indirect
PMID: 16713969
Figure 1
PMID: 16713969
TRAF-dependent induction of the kinases JNK, IKK-alpha, IKK-beta, IKK-gamma, TBK1, and IRAK1 induce the binding of the transcription factors ATF2-cJun complex, NF-KappaB (p50-p65 complex), IRF3, and IRF7 to sequence specific positive regulatory domains (PRD) located upstream of the interferon-beta start site.
PMID: 16713969
Figure1
PMID: 16713969
Figure1
PMID: 16713969
Figure1
PMID: 16713969
Figure1
PMID: 16713969
TRAF-dependent induction of the kinases JNK, IKK-alpha, IKK-beta, IKK-gamma, TBK1, and IRAK1 induce the binding of the transcription factors ATF2-cJun complex, NF-KappaB (p50-p65 complex), IRF3, and IRF7 to sequence specific positive regulatory domains (PRD) located upstream of the interferon-beta start site
indirect
PMID: 16713969
Coordinated assembly of these factors forms the interferon-beta enhanceosome, which is responsible for the transcriptional induction of this antiviral cytokine.
indirect
PMID: 16713969
The secreted IFN-beta induces the JAK-STAT signaling pathway in neighboring cells, leading to the activation of a large battery of IFN-stimulated genes (ISGs).
indirect
PMID: 16713969
The secreted IFN-beta induces the JAK-STAT signaling pathway in neighboring cells, leading to the activation of a large battery of IFN-stimulated genes (ISGs).
indirect
PMID: 16713969
The secreted IFN-beta induces the JAK-STAT signaling pathway in neighboring cells, leading to the activation of a large battery of IFN-stimulated genes (ISGs).
indirect
PMID: 16713969
The secreted IFN-beta induces the JAK-STAT signaling pathway in neighboring cells, leading to the activation of a large battery of IFN-stimulated genes (ISGs).