Entity
TNF-alpha
--
MO000000289
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m230
10
infinite
0
InterPro | IPR003636 |
TRANSPATH | MO000000289 |
--
COX-2
--
MO000017266
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m2122
10
infinite
0
InterPro | IPR002016 |
TRANSPATH | MO000017266 |
--
COX-1
--
MO000018979
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m3590
10
infinite
0
InterPro | IPR002016 |
TRANSPATH | MO000018979 |
--
LPS:LBP:CD14
--
MO000021929
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m6255
10
infinite
0
TRANSPATH | MO000021929 |
--
PGE2
--
MO000021939
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m346644
10
infinite
0
TRANSPATH | MO000021939 |
--
--
e1
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane
--
--
--
csml-variable:Double
m1
0
infinite
0
--
--
e10
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytosol
--
--
--
csml-variable:Double
m10
0
infinite
0
--
Il-1:IL-6R
--
e11
cso30:c:Complex
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m11
0
infinite
0
--
IL-1beta R
--
e12
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m12
0
infinite
0
--
IL-1beta:IL-1betaR
--
e13
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m13
0
infinite
0
--
TNF-alphaR
--
e14
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m14
0
infinite
0
--
TNF-alpha:TNF-alphaR
--
e15
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m15
0
infinite
0
--
IFN-gammaR
--
e16
cso30:c:Protein
cso30:i:CC_Nucleoplasm
--
--
csml-variable:Double
m16
0
infinite
0
--
IFN-gamma:IFN-gammaR
--
e17
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m17
0
infinite
0
--
Cox-2
--
e18
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m18
0
infinite
0
--
mPGES-1
--
e19
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
csml-variable:Double
m19
0
infinite
0
--
--
e2
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m2
0
infinite
0
--
cPLA2
--
e20
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m20
0
infinite
0
--
cPLA2{active}
--
e21
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m21
0
infinite
0
--
C3b
--
e22
cso30:c:Protein
cso30:i:CC_Extracellular
--
csml-variable:Double
m22
0
infinite
0
--
iC3b
--
e23
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m23
0
infinite
0
--
C3b
--
e24
cso30:c:Protein
cso30:i:CC_Extracellular
--
csml-variable:Double
m24
0
infinite
0
--
iC3b
--
e25
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m25
0
infinite
0
--
Phosphoinositide
--
e26
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m26
0
infinite
0
--
PI-PLC{active}
--
e27
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m27
0
infinite
0
--
Arachidonic acid
--
e28
cso30:c:SmallMolecule
cso30:i:CC_Cytosol
--
csml-variable:Double
m28
0
infinite
0
--
PI-PLC
--
e29
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m29
0
infinite
0
--
--
e3
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
--
csml-variable:Double
m3
0
infinite
0
--
Aspirin
--
e30
cso30:c:Protein
cso30:i:CC_Extracellular
--
csml-variable:Double
m30
0
infinite
0
--
mPGES-1
--
e31
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m31
0
infinite
0
--
pyrogens
--
e32
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m32
0
infinite
0
--
Gadolinium chloride
--
e33
cso30:c:SmallMolecule
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m33
0
infinite
0
--
CVF
--
e34
cso30:c:SmallMolecule
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m34
0
infinite
0
--
PGE2 anti serum
--
e35
cso30:c:Protein
cso30:i:CC_Nucleoplasm
--
--
csml-variable:Double
m35
0
infinite
0
--
serum c
--
e36
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m36
0
infinite
0
--
NE
--
e37
cso30:c:Protein
cso30:i:CC_Nucleoplasm
--
--
csml-variable:Double
m37
0
infinite
0
--
NE receptor
--
e38
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
csml-variable:Double
m38
0
infinite
0
--
NE:receptor
--
e39
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m39
0
infinite
0
--
--
e4
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m4
0
infinite
0
--
TLR4-MD-2
--
e5
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m5
0
infinite
0
--
--
e50
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelopeLumen
--
--
--
csml-variable:Double
m50
0
infinite
0
--
--
e51
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearPore
--
--
--
csml-variable:Double
m51
0
infinite
0
--
--
e52
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearInnerMembrane
--
--
--
csml-variable:Double
m52
0
infinite
0
--
--
e53
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearLumen
--
--
--
csml-variable:Double
m53
0
infinite
0
--
--
e54
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearOuterMembrane
--
--
--
csml-variable:Double
m54
0
infinite
0
--
--
e55
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleus
--
--
--
csml-variable:Double
m55
0
infinite
0
--
--
e56
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleoplasm
--
--
--
csml-variable:Double
m56
0
infinite
0
--
--
e57
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearBody
--
--
--
csml-variable:Double
m57
0
infinite
0
--
--
e58
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleolus
--
--
--
csml-variable:Double
m58
0
infinite
0
--
--
e59
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelope
--
--
--
csml-variable:Double
m59
0
infinite
0
--
TLR4:LPS
--
e6
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m6
0
infinite
0
--
--
e60
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Chromatin
--
--
--
csml-variable:Double
m60
0
infinite
0
--
--
e61
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearChromosome
--
--
--
csml-variable:Double
m61
0
infinite
0
--
--
e62
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearCentromere
--
--
--
csml-variable:Double
m62
0
infinite
0
--
--
e7
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell
--
--
--
csml-variable:Double
m7
0
infinite
0
--
--
e8
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell_WithoutCellWall_
--
--
--
csml-variable:Double
m8
0
infinite
0
--
--
e9
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytoplasm
--
--
--
csml-variable:Double
m9
0
infinite
0
--
p1
p1
cso30:i:ME_Binding
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1
m155666*m3985*0.1
nodelay
--
0
PMID:15967158,15051069 For example, PAMPs produced by cellwall components of Gram-negative bacteria (LPS) are recognized by TLR4; it involves the binding of LPS to a serum protein, lipopolysaccharide-binding protein (LPB), which in turn binds to membrane CD14, which transfers the complex to TLR4 in an MD-2-dependent manner
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1
m1639*m16*0.1
nodelay
--
0
PMID:15967158 They are then released into the bloodstream and transported to sites in or close to the POA that react to their stimulation by selectively expressing COX-2 and mPGES-1.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c27 : 1
stoichiometry:c31 : 1
m11*0.1
nodelay
--
0
PMID:15967158 They are then released into the bloodstream and transported to sites in or close to the POA that react to their stimulation by selectively expressing COX-2 and mPGES-1.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c32 : 1
m13*0.1
nodelay
--
0
PMID:15967158 They are then released into the bloodstream and transported to sites in or close to the POA that react to their stimulation by selectively expressing COX-2 and mPGES-1.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c33 : 1
stoichiometry:c37 : 1
m17*0.1
nodelay
--
0
PMID:15967158 They are then released into the bloodstream and transported to sites in or close to the POA that react to their stimulation by selectively expressing COX-2 and mPGES-1.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c38 : 1
m15*0.1
nodelay
--
0
PMID:15967158 They are then released into the bloodstream and transported to sites in or close to the POA that react to their stimulation by selectively expressing COX-2 and mPGES-1.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c39 : 1
m11*0.1
nodelay
--
0
PMID:15967158 They are then released into the bloodstream and transported to sites in or close to the POA that react to their stimulation by selectively expressing COX-2 and mPGES-1.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c36 : 1
stoichiometry:c40 : 1
m13*0.1
nodelay
--
0
PMID:15967158 They are then released into the bloodstream and transported to sites in or close to the POA that react to their stimulation by selectively expressing COX-2 and mPGES-1.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c41 : 1
stoichiometry:c42 : 1
m6*0.1
nodelay
--
0
PMID: 15967158,9748570,9880592,12957837,9917869,10578230 In support, LPS, like IL-1beta, induces these enzymes in endothelial cells of the cerebral microvasculature, including in the OVLT, the choroid plexi and the leptomeninges
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c44 : 1
m6*0.1
nodelay
--
0
PMID: 15967158,9748570,9880592,12957837,9917869,10578230 In support, LPS, like IL-1beta, induces these enzymes in endothelial cells of the cerebral microvasculature, including in the OVLT, the choroid plexi and the leptomeninges
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c46 : 1
stoichiometry:c47 : 1
m6*m20*0.1
nodelay
--
0
PMID: 15967158,8027674,12376404,14977603 Indeed, the activation by LPS of group IV cytosolic phospholipase (cPL)A2 is significantly delayed in vitro and in vivo
p2
p2
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1
m6254*m2828*0.1
nodelay
--
0
PMID:15967158,15051069 For example, PAMPs produced by cellwall components of Gram-negative bacteria (LPS) are recognized by TLR4; it involves the binding of LPS to a serum protein, lipopolysaccharide-binding protein (LPB), which in turn binds to membrane CD14, which transfers the complex to TLR4 in an MD-2-dependent manner
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c48 : 1
stoichiometry:c49 : 1
m13*0.1
nodelay
--
0
PMID: 15967158,7664696,8193936 the expression of c-fos in the nucleus of the solitary tract (NTS, the primary projection area of the vagus nerves) is enhanced after i.v. and i.p. IL-1beta and i.v. LPS
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c51 : 1
m6*0.1
nodelay
--
0
PMID: 15967158,7664696,8193936 the expression of c-fos in the nucleus of the solitary tract (NTS, the primary projection area of the vagus nerves) is enhanced after i.v. and i.p. IL-1beta and i.v. LPS
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c53 : 1
m6*0.1
nodelay
--
0
PMID: 15967158 Together, these data, plus others not described, thus substantiate the notion that circulating LPS arriving in the liver could activate Kc to produce and release TNFalpha, IL-1beta and IL-6
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c56 : 1
m6*0.1
nodelay
--
0
PMID: 15967158 Together, these data, plus others not described, thus substantiate the notion that circulating LPS arriving in the liver could activate Kc to produce and release TNFalpha, IL-1beta and IL-6
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c57 : 1
m6*0.1
nodelay
--
0
PMID: 15967158 Together, these data, plus others not described, thus substantiate the notion that circulating LPS arriving in the liver could activate Kc to produce and release TNFalpha, IL-1beta and IL-6
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c59 : 1
m93309*0.1
nodelay
--
0
PMID: 15967158 Together, these data, plus others not described, thus substantiate the notion that circulating LPS arriving in the liver could activate Kc to produce and release TNFalpha, IL-1beta and IL-6
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c61 : 1
m93248*0.1
nodelay
--
0
PMID: 15967158 Together, these data, plus others not described, thus substantiate the notion that circulating LPS arriving in the liver could activate Kc to produce and release TNFalpha, IL-1beta and IL-6
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1
stoichiometry:c63 : 1
m93364*0.1
nodelay
--
0
PMID: 15967158 Together, these data, plus others not described, thus substantiate the notion that circulating LPS arriving in the liver could activate Kc to produce and release TNFalpha, IL-1beta and IL-6
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c66 : 1
stoichiometry:c67 : 1
m6*0.1
nodelay
--
0
PMID: 15967158 Indeed, the i.v. administration of LPS triggers within 2 min the C cascade via the alternative pathway, resulting in the production in blood of C4a, C3a and C5a and of surface-bound and fluid-phase C3b and iC3b
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1
stoichiometry:c69 : 1
m6*0.1
nodelay
--
0
PMID: 15967158 Indeed, the i.v. administration of LPS triggers within 2 min the C cascade via the alternative pathway, resulting in the production in blood of C4a, C3a and C5a and of surface-bound and fluid-phase C3b and iC3b
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1
m6438*m3961*0.1
nodelay
--
0
PMID:15967158,15051069 For example, PAMPs produced by cellwall components of Gram-negative bacteria (LPS) are recognized by TLR4; it involves the binding of LPS to a serum protein, lipopolysaccharide-binding protein (LPB), which in turn binds to membrane CD14, which transfers the complex to TLR4 in an MD-2-dependent manner
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1
stoichiometry:c71 : 1
m6*0.1
nodelay
--
0
PMID: 15967158 Indeed, the i.v. administration of LPS triggers within 2 min the C cascade via the alternative pathway, resulting in the production in blood of C4a, C3a and C5a and of surface-bound and fluid-phase C3b and iC3b
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c74 : 1
m6*0.1
nodelay
--
0
PMID: 15967158 Indeed, the i.v. administration of LPS triggers within 2 min the C cascade via the alternative pathway, resulting in the production in blood of C4a, C3a and C5a and of surface-bound and fluid-phase C3b and iC3b
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c75 : 1
m6*0.1
nodelay
--
0
PMID: 15967158 Indeed, the i.v. administration of LPS triggers within 2 min the C cascade via the alternative pathway, resulting in the production in blood of C4a, C3a and C5a and of surface-bound and fluid-phase C3b and iC3b
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c78 : 1
m6*0.1
nodelay
--
0
PMID: 15967158 Indeed, the i.v. administration of LPS triggers within 2 min the C cascade via the alternative pathway, resulting in the production in blood of C4a, C3a and C5a and of surface-bound and fluid-phase C3b and iC3b
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c79 : 1
m6*0.1
nodelay
--
0
PMID: 15967158 Indeed, the i.v. administration of LPS triggers within 2 min the C cascade via the alternative pathway, resulting in the production in blood of C4a, C3a and C5a and of surface-bound and fluid-phase C3b and iC3b
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c80 : 1
stoichiometry:c82 : 1
stoichiometry:c111 : 1
stoichiometry:c81 : 1
m26*m27*0.1
nodelay
--
0
PMID: 15967158 PGE2, under these conditions, could be generated via the hydrolysis of membrane-associated phosphoinositide (PI, which has a high arachydonoyl chain content) by PI-specific phospholipase C (PI-PLC) PMID: 15967158,5284360 Vane demonstrated that aspirin blocks prostaglandin synthesis
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c84 : 1
m27*0.1
nodelay
--
0
PMID: 15967158 indeed, arachidonic acid (AA) liberation by PI-PLC is 10-fold more rapid (within seconds) than that mediated by cPLA2 PMID: 15967158 Moreover, PI-PLC is reportedly activated by C, but not by LPS or IL-1beta, and the subsequent conversion of this AA to PGE2 is catalyzed by COX-1
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c85 : 1
stoichiometry:c86 : 1
m21*0.1
nodelay
--
0
PMID: 15967158, indeed, arachidonic acid (AA) liberation by PI-PLC is 10-fold more rapid (within seconds) than that mediated by cPLA2
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c88 : 1
stoichiometry:c89 : 1
m22*m29*0.1
nodelay
--
0
PMID: 15967158 Moreover, PI-PLC is reportedly activated by C, but not by LPS or IL-1beta, and the subsequent conversion of this AA to PGE2 is catalyzed by COX-1
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c90 : 1
stoichiometry:c91 : 1
stoichiometry:c92 : 1
m23*m29*0.1
nodelay
--
0
PMID: 15967158 Moreover, PI-PLC is reportedly activated by C, but not by LPS or IL-1beta, and the subsequent conversion of this AA to PGE2 is catalyzed by COX-1
p2
p4
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1
stoichiometry:c64 : 1
stoichiometry:c65 : 1
m5*m6255*0.1
nodelay
--
0
PMID:15967158,15051069 For example, PAMPs produced by cellwall components of Gram-negative bacteria (LPS) are recognized by TLR4; it involves the binding of LPS to a serum protein, lipopolysaccharide-binding protein (LPB), which in turn binds to membrane CD14, which transfers the complex to TLR4 in an MD-2-dependent manner
p38
p40
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c94 : 1
stoichiometry:c95 : 1
m44674*m29*0.1
nodelay
--
0
PMID: 15967158 Moreover, PI-PLC is reportedly activated by C, but not by LPS or IL-1beta, and the subsequent conversion of this AA to PGE2 is catalyzed by COX-1
p38
p41
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c96 : 1
stoichiometry:c97 : 1
stoichiometry:c98 : 1
m13505*m29*0.1
nodelay
--
0
PMID: 15967158 Moreover, PI-PLC is reportedly activated by C, but not by LPS or IL-1beta, and the subsequent conversion of this AA to PGE2 is catalyzed by COX-1
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c100 : 1
stoichiometry:c101 : 1
m24*m29*0.1
nodelay
--
0
PMID: 15967158 Moreover, PI-PLC is reportedly activated by C, but not by LPS or IL-1beta, and the subsequent conversion of this AA to PGE2 is catalyzed by COX-1
p38
p43
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c102 : 1
stoichiometry:c103 : 1
stoichiometry:c104 : 1
m12280*m29*0.1
nodelay
--
0
PMID: 15967158 Moreover, PI-PLC is reportedly activated by C, but not by LPS or IL-1beta, and the subsequent conversion of this AA to PGE2 is catalyzed by COX-1
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c105 : 1
stoichiometry:c106 : 1
stoichiometry:c107 : 1
m25*m29*0.1
nodelay
--
0
PMID: 15967158 Moreover, PI-PLC is reportedly activated by C, but not by LPS or IL-1beta, and the subsequent conversion of this AA to PGE2 is catalyzed by COX-1
p45
p45
cso30:i:ME_UnknownProduction
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c108 : 1
stoichiometry:c110 : 1
stoichiometry:c112 : 1
stoichiometry:c109 : 1
m28*m3590*0.1
nodelay
--
0
PMID: 15967158 Moreover, PI-PLC is reportedly activated by C, but not by LPS or IL-1beta, and the subsequent conversion of this AA to PGE2 is catalyzed by COX-1 PMID: 15967158,5284360 Vane demonstrated that aspirin blocks prostaglandin synthesis
p46
p46
cso30:i:ME_UnknownProduction
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c113 : 1
stoichiometry:c122 : 1
stoichiometry:c114 : 1
m19*0.1
nodelay
--
0
PMID: 15967158,11113021,11113018 Thus, it is now generally believed that cyclooxygenase (COX)-2 and microsomal prostaglandin E synthase (mPGES)-1 selectively induced by pyrogenic cytokines catalyze its production, and that it acts in the preoptic-anterior hypothalamus (POA), the brain site of the primary thermoregulatory controller PMID: 15967158 The second step of the conventional sequence asserts that the synthesis of PGE2 is effected in the POA via catalysis by COX-2 and mPGES-1 PMID: 15967158,5284360 Vane demonstrated that aspirin blocks prostaglandin synthesis
p46
p47
cso30:i:ME_UnknownProduction
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c115 : 1
stoichiometry:c121 : 1
stoichiometry:c116 : 1
m18*0.1
nodelay
--
0
PMID: 15967158,11113021,11113018 Thus, it is now generally believed that cyclooxygenase (COX)-2 and microsomal prostaglandin E synthase (mPGES)-1 selectively induced by pyrogenic cytokines catalyze its production, and that it acts in the preoptic-anterior hypothalamus (POA), the brain site of the primary thermoregulatory controller PMID: 15967158 The second step of the conventional sequence asserts that the synthesis of PGE2 is effected in the POA via catalysis by COX-2 and mPGES-1 PMID: 15967158,5284360 Vane demonstrated that aspirin blocks prostaglandin synthesis
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c117 : 1
stoichiometry:c118 : 1
m18*0.1
nodelay
--
0
PMID: 15967158,9453538,1570314,7631045,10223523 Moreover, the transcription and translation of inducible COX-2 and mPGES-1 by inflammatory stimuli, LPS and IL-1beta alike, require at least 1 h in vitro
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c119 : 1
stoichiometry:c120 : 1
m19*0.1
nodelay
--
0
PMID: 15967158,9453538,1570314,7631045,10223523 Moreover, the transcription and translation of inducible COX-2 and mPGES-1 by inflammatory stimuli, LPS and IL-1beta alike, require at least 1 h in vitro
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c26 : 1
stoichiometry:c30 : 1
m15*0.1
nodelay
--
0
PMID:15967158 They are then released into the bloodstream and transported to sites in or close to the POA that react to their stimulation by selectively expressing COX-2 and mPGES-1.
p50
p50
cso30:i:ME_UnknownProduction
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c123 : 1
stoichiometry:c125 : 1
stoichiometry:c124 : 1
m32*0.1
nodelay
--
0
PMID: 15967158,14977603,15492017,11262580,15353338,15373964 the consensus has now developed that the febrile response to LPS (and also to live bacteria is probably not initiated by newly generated, blood-borne pyrogenic cytokines, but rather by the production of PGE2 directly stimulated in the periphery by the exogenous pyrogens themselves PMID: 15967158,5284360 Vane demonstrated that aspirin blocks prostaglandin synthesis
p51
p51
cso30:i:ME_ChangeInMaterialConcentration
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c126 : 1
stoichiometry:c128 : 1
stoichiometry:c129 : 1
stoichiometry:c130 : 1
stoichiometry:c127 : 1
m6*0.1
nodelay
--
0
PMID: 15967158 In conscious guinea pigs, Tc and plasma PGE2 rise simultaneously and concurrently with the first appearance in Kc of i.v. or i.p. injected LPS. PMID: 15967158,9100920,9608013,10600909 The associated Kc uptake of i.v. or i.p. LPS, the rise in plasma PGE2 and the febrile response are prevented by pre-treatment with gadolinium chloride, an agent that temporarily depletes Kc, or with CVF, a decomplementing toxin PMID: 15967158 Pre-treatment with PGE2 anti-serum (which does not cross the BBB) reduces the rises in Tc and plasma and preoptic PGE2 induced by i.v. LPS in conscious guinea pigs
p52
p52
cso30:i:ME_UnknownProduction
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c131 : 1
stoichiometry:c134 : 1
stoichiometry:c151 : 1
stoichiometry:c132 : 1
m36*m3590*0.1
nodelay
--
0
PMID: 15967158 The addition of serum C alone or in combination with LPS, but not of LPS alone, to primary Kc from guinea pigs and mice in vitro provokes the virtually immediate, near-maximal release of PGE2 by these cells; this response is catalyzed nondifferentially by COX-1 and COX-2 (constitutive in Kc).
p52
p53
cso30:i:ME_UnknownProduction
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c133 : 1
stoichiometry:c135 : 1
stoichiometry:c152 : 1
stoichiometry:c136 : 1
m36*m2122*0.1
nodelay
--
0
PMID: 15967158 The addition of serum C alone or in combination with LPS, but not of LPS alone, to primary Kc from guinea pigs and mice in vitro provokes the virtually immediate, near-maximal release of PGE2 by these cells; this response is catalyzed nondifferentially by COX-1 and COX-2 (constitutive in Kc).
p52
p54
cso30:i:ME_UnknownProduction
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c137 : 1
stoichiometry:c138 : 1
stoichiometry:c139 : 1
stoichiometry:c150 : 1
stoichiometry:c140 : 1
m36*m6*m3590*0.1
nodelay
--
0
PMID: 15967158 The addition of serum C alone or in combination with LPS, but not of LPS alone, to primary Kc from guinea pigs and mice in vitro provokes the virtually immediate, near-maximal release of PGE2 by these cells; this response is catalyzed nondifferentially by COX-1 and COX-2 (constitutive in Kc).
p52
p55
cso30:i:ME_UnknownProduction
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c141 : 1
stoichiometry:c142 : 1
stoichiometry:c143 : 1
stoichiometry:c153 : 1
stoichiometry:c144 : 1
m2122*m6*m36*0.1
nodelay
--
0
PMID: 15967158 The addition of serum C alone or in combination with LPS, but not of LPS alone, to primary Kc from guinea pigs and mice in vitro provokes the virtually immediate, near-maximal release of PGE2 by these cells; this response is catalyzed nondifferentially by COX-1 and COX-2 (constitutive in Kc).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c145 : 1
stoichiometry:c146 : 1
stoichiometry:c147 : 1
m37*m38*0.1
nodelay
--
0
PMID: 15967158,4145320 NE also stimulates the release of PGE2 in brain tissue in vitro
p57
p57
cso30:i:ME_UnknownProduction
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c148 : 1
stoichiometry:c149 : 1
m39*0.1
nodelay
--
0
PMID: 15967158,4145320 NE also stimulates the release of PGE2 in brain tissue in vitro PMID: 15967158,5284360 Vane demonstrated that aspirin blocks prostaglandin synthesis
p6
p6
cso30:i:ME_Binding
cso30:i:CC_Nucleoplasm
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1
m3096*m871*0.1
nodelay
--
0
PMID:15967158 They are then released into the bloodstream and transported to sites in or close to the POA that react to their stimulation by selectively expressing COX-2 and mPGES-1.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c29 : 1
m17*0.1
nodelay
--
0
PMID:15967158 They are then released into the bloodstream and transported to sites in or close to the POA that react to their stimulation by selectively expressing COX-2 and mPGES-1.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1
m1591*m12*0.1
nodelay
--
0
PMID:15967158 They are then released into the bloodstream and transported to sites in or close to the POA that react to their stimulation by selectively expressing COX-2 and mPGES-1.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1
m230*m14*0.1
nodelay
--
0
PMID:15967158 They are then released into the bloodstream and transported to sites in or close to the POA that react to their stimulation by selectively expressing COX-2 and mPGES-1.
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputInhibitor
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--