majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:15802263.csml convertedTime:2009.07.01.10:50

Entity

G010262:IL-6 G010329:TNF-alpha G010514:iNOS G010815:MCP1 G029941:COX2 MO000000011:ERK MO000000022:p38 MO000000023:JNK MO000000058:NF-kappaB{active} MO000000059:SRF{active} MO000000276:AP-1 MO000000289:TNF-alpha MO000007330:proIL-18 MO000007384:IL-6 MO000016597:IL-1beta MO000016625:IL-18 MO000016828:Caspase-1 MO000016894:MAPK MO000017189:CREB{active} MO000017264:IL-8 MO000017266:COX-2 MO000017280:MCP-1 MO000017949:RIP2 MO000019397:TLR2 MO000019449:proIL-1beta MO000019886:MIP-1alpha MO000020434:Nod1 MO000020461:Nod2 MO000021201:iNOS MO000042032:PGN MO000044014:ASC MO000061612:CARD8 MO000116924:Cryopyrin e1: e10: e11:Nod1 oligomer:iE-DAP e12:Nod1 oligomer:iE-DAP:RIP2 e13:IKK complex(IKKalpha:IKKbeta:IKKgamma) e14:IKk complex(IKKalpha:IKKbeta:IKKgamma){active} e15:IKappaB-alpha:NF-KappaB e16:IKappaB-alpha{p}:NF-KappaB e17:protein remnants e18:NF-kappaB e19:AP-1{active} e2: e20:MAPK{active} e21:JNK{active} e22:ERK{active} e23:p38{active} e24:SRF e25:CREB e26:IL-8 e27:MIP-1alpha e28:VCAM e29:VCAM e3: e30:ICAM e31:ICAM e32:E-selectin e33:E-selectin e34:Nod2 oligomer:PGN (MDP) e35:Nod2:MDP e36:Nod2 oligomer:PGN(MDP):RIP2 e37:IKk complex(IKKalpha:IKKbeta:IKKgamma{p}){active} e38:NF-kappaB e39:MDP e4: e40:Cryopyrin:MDP e41:CIAS1 e42:cryopyrin e43:Cryopyrin:ASC:CARD8:caspase-1 e44:Lipoproteins e45:TLR2:Lipoproteins e46:Lipoteichoic acid e47:TLR2:Lipoteichoic acid e48:PGRPs e49:PGN e5:iE-DAP e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:Nod1:iE-DAP e60: e61: e62: e63:PGRPs:PGN e64:Bacteria e65:PGRPs:Bacteria e66:PGRP-L e67:PGRP-L:PGN e68:Remnants e7: e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p65 p66 p67 p68 p69 p7 p70 p71 p72 p73 p74 p75 p76 p77 p78 p79 p8 p80 p81 p82 p83 p84 p85 p86 p87 p88 p89 p9 p90 p91 p92
387.0, 995.0
26.0, 26.0

IL-6

--

G010262

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p9 p30 p40 p31

p23

true true true true

csml-variable:Double

m93248

10

false

infinite

0

unit false false false
TRANSFACG010262

--

Go back
310.0, 1162.0
20.0, 20.0

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p26 p44 p45 p46

p27

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
371.0, 1307.0
26.0, 26.0

iNOS

--

G010514

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p62 p64 p65 p66

p63

true true true true

csml-variable:Double

m93479

10

false

infinite

0

unit false false false
TRANSFACG010514

--

Go back
321.0, 1209.0
22.5, 22.5

MCP1

--

G010815

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p28 p47 p48 p49

p29

true true true true

csml-variable:Double

m93710

10

false

infinite

0

unit false false false
TRANSFACG010815

--

Go back
424.0, 1336.0
24.0, 24.0

COX2

--

G029941

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p68 p69 p70 p71

p67

true true true true

csml-variable:Double

m108639

10

false

infinite

0

unit false false false
TRANSFACG029941

--

Go back
578.0, 694.0
28.5, 28.5

ERK

--

MO000000011

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p12

true true true true

csml-variable:Double

m24

10

false

infinite

0

unit false false false
TRANSPATHMO000000011

--

Go back
783.0, 727.0
18.0, 18.0

p38

--

MO000000022

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13

true true true true

csml-variable:Double

m26

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
843.0, 667.0
18.0, 18.0

JNK

--

MO000000023

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11

true true true true

csml-variable:Double

m22

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
527.0, 903.0
26.0, 26.0

NF-kappaB{active}

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

p7 p78

p8

true true true true

csml-variable:Double

m18

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
775.0, 1075.0
17.5, 17.5

SRF{active}

--

MO000000059

cso30:c:Protein

cso30:i:CC_CellComponent

--

p17 p18 p19

p30 p41 p44 p47 p50 p53 p56 p61 p65 p69

true true true true

csml-variable:Double

m28

10

false

infinite

0

unit false false false
InterProIPR005829
TRANSPATHMO000000059

--

Go back
601.0, 897.0
22.0, 22.0

AP-1

--

MO000000276

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14 p15 p16

true true true true

csml-variable:Double

m219

10

false

infinite

0

unit false false false
TRANSPATHMO000000276

--

Go back
105.0, 1145.0
22.0, 22.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

p27

--

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
708.0, 644.0
18.0, 18.0

proIL-18

--

MO000007330

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p86

true true true true

csml-variable:Double

m841

10

false

infinite

0

unit false false false
InterProIPR008996
TRANSPATHMO000007330

--

Go back
113.0, 977.0
22.0, 22.0

IL-6

--

MO000007384

cso30:c:Protein

cso30:i:CC_CellComponent

--

p23

--

true true true true

csml-variable:Double

m871

10

false

infinite

0

unit false false false
InterProIPR003573
TRANSPATHMO000007384

--

Go back
1045.0, 557.0
22.0, 22.0

IL-1beta

--

MO000016597

cso30:c:Protein

cso30:i:CC_CellComponent

--

p85

--

true true true true

csml-variable:Double

m1591

10

false

infinite

0

unit false false false
TRANSPATHMO000016597

--

Go back
1034.0, 634.0
20.0, 20.0

IL-18

--

MO000016625

cso30:c:Protein

cso30:i:CC_CellComponent

--

p86

--

true true true true

csml-variable:Double

m1611

10

false

infinite

0

unit false false false
InterProIPR008996
TRANSPATHMO000016625

--

Go back
884.0, 520.0
24.0, 24.0

Caspase-1

--

MO000016828

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p83

true true true true

csml-variable:Double

m1765

10

false

infinite

0

unit false false false
TRANSPATHMO000016828

--

Go back
476.0, 600.0
23.0, 23.0

MAPK

--

MO000016894

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10 p79

true true true true

csml-variable:Double

m1812

10

false

infinite

0

unit false false false
TRANSPATHMO000016894

--

Go back
842.0, 1010.0
20.0, 20.0

CREB{active}

--

MO000017189

cso30:c:Protein

cso30:i:CC_CellComponent

--

p20 p21 p22

p31 p43 p46 p49 p52 p55 p58 p60 p64 p71 p72

true true true true

csml-variable:Double

m2057

10

false

infinite

0

unit false false false
InterProIPR003102
TRANSPATHMO000017189

--

Go back
117.0, 1061.0
22.0, 22.0

IL-8

--

MO000017264

cso30:c:Protein

cso30:i:CC_CellComponent

--

p25

--

true true true true

csml-variable:Double

m2120

10

false

infinite

0

unit false false false
InterProIPR002473
TRANSPATHMO000017264

--

Go back
296.0, 1396.0
16.0, 16.0

COX-2

--

MO000017266

cso30:c:Protein

cso30:i:CC_CellComponent

--

p67

--

true true true true

csml-variable:Double

m2122

10

false

infinite

0

unit false false false
InterProIPR002016
TRANSPATHMO000017266

--

Go back
111.0, 1211.0
18.5, 18.5

MCP-1

--

MO000017280

cso30:c:Protein

cso30:i:CC_CellComponent

--

p29

--

true true true true

csml-variable:Double

m2133

10

false

infinite

0

unit false false false
InterProIPR008097
TRANSPATHMO000017280

--

Go back
426.0, 546.0
19.0, 19.0

RIP2

--

MO000017949

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4 p75

true true true true

csml-variable:Double

m2684

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000017949

--

Go back
179.0, 375.0
18.0, 18.0

TLR2

--

MO000019397

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p87 p88

true true true true

csml-variable:Double

m3964

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019397

--

Go back
851.0, 603.0
18.0, 18.0

proIL-1beta

--

MO000019449

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p85

true true true true

csml-variable:Double

m4012

10

false

infinite

0

unit false false false
InterProIPR003297
TRANSPATHMO000019449

--

Go back
113.0, 1265.0
22.0, 22.0

MIP-1alpha

--

MO000019886

cso30:c:Protein

cso30:i:CC_CellComponent

--

p32

--

true true true true

csml-variable:Double

m4415

10

false

infinite

0

unit false false false
InterProIPR000827
TRANSPATHMO000019886

--

Go back
375.0, 399.0
18.0, 18.0

Nod1

--

MO000020434

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m4923

10

false

infinite

0

unit false false false
InterProIPR007091
TRANSPATHMO000020434

--

Go back
562.0, 338.0
19.0, 19.0

Nod2

--

MO000020461

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p73

true true true true

csml-variable:Double

m4947

10

false

infinite

0

unit false false false
TRANSPATHMO000020461

--

Go back
241.0, 1321.0
22.0, 22.0

iNOS

--

MO000021201

cso30:c:Protein

cso30:i:CC_CellComponent

--

p63

--

true true true true

csml-variable:Double

m5576

10

false

infinite

0

unit false false false
TRANSPATHMO000021201

--

Go back
387.0, 331.0
17.0, 17.0

PGN

--

MO000042032

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2 p73

true true true true

csml-variable:Double

m155701

10

false

infinite

0

unit false false false
TRANSPATHMO000042032

--

Go back
835.0, 407.0
18.0, 18.0

ASC

--

MO000044014

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p83

true true true true

csml-variable:Double

m21736

10

false

infinite

0

unit false false false
InterProIPR004020
TRANSPATHMO000044014

--

Go back
882.0, 458.0
20.0, 20.0

CARD8

--

MO000061612

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p83

true true true true

csml-variable:Double

m36509

10

false

infinite

0

unit false false false
TRANSPATHMO000061612

--

Go back
718.0, 338.0
19.0, 19.0

Cryopyrin

--

MO000116924

cso30:c:Protein

cso30:i:CC_CellComponent

--

p82

p80

true true true true

csml-variable:Double

m86033

10

false

infinite

0

unit false false false
TRANSPATHMO000116924

--

Go back
155.75, 249.9969080091176
856.2594311764528, 1243.2886940682085

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
157.0, 268.0
829.9775981223105, 1167.545103664102

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
307.5, 617.0
24.438760206632235, 29.92501249791702

Nod1 oligomer:iE-DAP

--

e11

cso30:c:Complex

cso30:i:CC_Cytosol

--

p3

p4

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
299.0, 729.0
18.088235294117645, 30.147058823529417

Nod1 oligomer:iE-DAP:RIP2

--

e12

cso30:c:Complex

cso30:i:CC_Cytosol

--

p4

p5 p10

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
529.5, 718.0
20.770049550376214, 28.981464488897046

IKK complex(IKKalpha:IKKbeta:IKKgamma)

--

e13

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p5 p76 p84

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
293.5, 782.0
20.770049550376214, 28.981464488897046

IKk complex(IKKalpha:IKKbeta:IKKgamma){active}

--

e14

cso30:c:Complex

cso30:i:CC_Cytosol

--

p5 p76 p84

p6 p77

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
554.5, 784.0
18.9925012497917, 23.256123979336778

IKappaB-alpha:NF-KappaB

--

e15

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p6

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
290.5, 872.0
18.9925012497917, 23.256123979336778

IKappaB-alpha{p}:NF-KappaB

--

e16

cso30:c:Complex

cso30:i:CC_Cytosol

--

p6

p7

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
549.0, 845.0
21.918437679494545, 21.18782309017806

protein remnants

--

e17

cso30:c:EntityBiological

cso30:i:CC_Cytosol

--

p7

--

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
535.0, 1059.0
26.0, 26.0

NF-kappaB

--

e18

cso30:c:Protein

cso30:i:CC_CellComponent

--

p8

p9 p24 p26 p28 p33 p34 p36 p38 p62 p68

true true true true

csml-variable:Double

m19

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
889.0, 1141.0
22.0, 22.0

AP-1{active}

--

e19

cso30:c:Protein

cso30:i:CC_CellComponent

--

p14 p15 p16

p40 p42 p45 p48 p51 p54 p57 p59 p66 p68 p70

true true true true

csml-variable:Double

m20

10

false

infinite

0

unit false false false
TRANSPATHMO000000276

--

Go back
155.75, 249.9969080091176
856.2594311764528, 1243.2886940682085

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
644.0, 664.0
23.0, 23.0

MAPK{active}

--

e20

cso30:c:Protein

cso30:i:CC_CellComponent

--

p10 p79

p11 p12 p13

true true true true

csml-variable:Double

m21

10

false

infinite

0

unit false false false
TRANSPATHMO000016894

--

Go back
883.0, 723.0
18.0, 18.0

JNK{active}

--

e21

cso30:c:Protein

cso30:i:CC_CellComponent

--

p11

p16 p19 p20

true true true true

csml-variable:Double

m23

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
622.0, 822.0
28.5, 28.5

ERK{active}

--

e22

cso30:c:Protein

cso30:i:CC_CellComponent

--

p12

p14 p17 p22

true true true true

csml-variable:Double

m25

10

false

infinite

0

unit false false false
TRANSPATHMO000000011

--

Go back
687.0, 799.0
18.0, 18.0

p38{active}

--

e23

cso30:c:Protein

cso30:i:CC_CellComponent

--

p13

p15 p18 p21

true true true true

csml-variable:Double

m27

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
811.0, 919.0
17.5, 17.5

SRF

--

e24

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p17 p18 p19

true true true true

csml-variable:Double

m29

10

false

infinite

0

unit false false false
InterProIPR005829
TRANSPATHMO000000059

--

Go back
902.0, 938.0
20.0, 20.0

CREB

--

e25

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20 p21 p22

true true true true

csml-variable:Double

m30

10

false

infinite

0

unit false false false
InterProIPR003102
TRANSPATHMO000017189

--

Go back
310.0, 1058.0
36.384083044982695, 19.404844290657437

IL-8

--

e26

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p24 p41 p42 p43

p25

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
365.0, 1260.0
45.1038062283737, 24.055363321799312

MIP-1alpha

--

e27

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p33 p50 p51 p52 p72

p32

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
557.0, 1338.0
37.78546712802768, 20.1522491349481

VCAM

--

e28

cso30:c:mRNA

cso30:i:CC_Cytosol

--

p34 p53 p54 p55

p35

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
568.5, 1444.0
14.914670959951701, 24.185952908029783

VCAM

--

e29

cso30:c:Protein

cso30:i:CC_Cytosol

--

p35

--

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
172.87518862352903, 267.1220966326467
822.0090539293948, 1209.0383168211513

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
623.0, 1309.0
41.21107266435986, 21.97923875432526

ICAM

--

e30

cso30:c:mRNA

cso30:i:CC_Cytosol

--

p36 p56 p57 p58

p37

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
649.0, 1447.5
22.559999999999995, 16.92

ICAM

--

e31

cso30:c:Protein

cso30:i:CC_Cytosol

--

p37

--

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
692.0, 1253.0
40.8477508650519, 21.78546712802768

E-selectin

--

e32

cso30:c:mRNA

cso30:i:CC_Cytosol

--

p38 p59 p60 p61

p39

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
730.0, 1498.0
12.136576239476145, 28.007483629560337

E-selectin

--

e33

cso30:c:Protein

cso30:i:CC_Cytosol

--

p39

--

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
597.5, 499.0
21.605399100149977, 26.45559073487753

Nod2 oligomer:PGN (MDP)

--

e34

cso30:c:Complex

cso30:i:CC_Cytosol

--

p74

p75

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
572.5, 443.0
22.0299950008332, 26.97550408265289

Nod2:MDP

--

e35

cso30:c:Complex

cso30:i:CC_Cytosol

--

p73

p74

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
634.0, 575.0
20.823529411764703, 34.70588235294118

Nod2 oligomer:PGN(MDP):RIP2

--

e36

cso30:c:Complex

cso30:i:CC_Cytosol

--

p75

p76 p79

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
313.5, 918.0
20.770049550376214, 28.981464488897046

IKk complex(IKKalpha:IKKbeta:IKKgamma{p}){active}

--

e37

cso30:c:Complex

cso30:i:CC_Cytosol

--

p77

p78

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
415.0, 823.0
26.0, 26.0

NF-kappaB

--

e38

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p78

true true true true

csml-variable:Double

m43

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
826.0, 340.0
43.952901597981494, 24.906644238856178

MDP

--

e39

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p80

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
204.55678757705792, 297.09117672382234
758.6458560223374, 1149.1001566387988

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
726.5, 468.0
19.310948175304116, 23.646058990168306

Cryopyrin:MDP

--

e40

cso30:c:Complex

cso30:i:CC_Cytosol

--

p80

p83

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
582.0, 1069.5
60.0, 13.0

CIAS1

--

e41

cso30:c:Dna

cso30:i:CC_Cytosol

--

--

p81

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
544.0, 965.0
39.96539792387543, 21.314878892733564

cryopyrin

--

e42

cso30:c:mRNA

cso30:i:CC_Cytosol

--

p81

p82

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
806.0, 535.0
20.11764705882353, 33.529411764705884

Cryopyrin:ASC:CARD8:caspase-1

--

e43

cso30:c:Complex

cso30:i:CC_Cytosol

--

p83

p84 p85 p86

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
93.0, 317.0
37.897392767031114, 21.475189234650966

Lipoproteins

--

e44

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p87

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
266.5, 265.0
19.221223415917557, 37.20236790177592

TLR2:Lipoproteins

--

e45

cso30:c:Complex

cso30:i:CC_Cytosol

--

p87

--

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
81.0, 437.0
38.52817493692178, 21.832632464255674

Lipoteichoic acid

--

e46

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p88

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
178.5, 477.0
19.75137031352773, 38.228458671343994

TLR2:Lipoteichoic acid

--

e47

cso30:c:Complex

cso30:i:CC_Cytosol

--

p88

--

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
382.0, 168.5
20.959999999999997, 15.720000000000002

PGRPs

--

e48

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p89 p90

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
551.0, 135.0
17.0, 17.0

PGN

--

e49

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p89 p91

true true true true

csml-variable:Double

m67

10

false

infinite

0

unit false false false
TRANSPATHMO000042032

--

Go back
494.0, 398.0
35.82842724978973, 20.302775441547514

iE-DAP

--

e5

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p2

p1

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
273.1197705969883, 942.0
504.75269723597506, 457.7552393927745

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
327.6368216951012, 952.8481337021642
295.14403525530025, 443.65600203981467

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
279.69941469503624, 948.1096695196159
491.5934090398785, 445.53590035354244

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
280.6393638519005, 949.0496186764803
489.7135107261509, 443.65600203981467

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
273.1197705969883, 942.0
504.75269723597506, 457.7552393927745

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
273.1197705969883, 942.0
504.75269723597506, 457.7552393927745

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
280.6393638519005, 949.0496186764803
489.7135107261509, 443.65600203981467

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
641.5798400876813, 1129.9898313728013
31.53417515755244, 28.54672698473175

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
558.8643142836484, 1261.5827133337657
89.29516990208117, 80.83562749030526

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
273.1197705969883, 942.0
504.75269723597506, 457.7552393927745

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
329.5, 488.0
20.0948175304116, 24.605899016830527

Nod1:iE-DAP

--

e6

cso30:c:Complex

cso30:i:CC_Cytosol

--

p1

p3

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
392.0871412875649, 1145.422645923467
15.984776265281177, 7.696373757357613

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
391.5533643618541, 1122.4702381178904
54.71213488538634, 98.48184279369553

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
414.505772167431, 1186.5234692032197
8.54043081137738, 8.540430811377389

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
501.5, 179.0
20.968505249125144, 25.675720713214467

PGRPs:PGN

--

e63

cso30:c:Complex

cso30:i:CC_Extracellular

--

p89

--

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
295.5, 76.0
16.505586063245598, 24.154516190115505

Bacteria

--

e64

cso30:c:Cell

cso30:i:CC_Extracellular

--

--

p90

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
288.5, 161.0
15.364324938458623, 22.484377958719932

PGRPs:Bacteria

--

e65

cso30:c:Cell

cso30:i:CC_Extracellular

--

p90

--

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
616.0, 90.5
24.31999999999999, 18.239999999999995

PGRP-L

--

e66

cso30:c:Protein

cso30:i:CC_Extracellular

--

p92

p91

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
690.5, 200.0
18.919013497750377, 23.166138976837196

PGRP-L:PGN

--

e67

cso30:c:Complex

cso30:i:CC_Extracellular

--

p91

p92

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
845.0, 161.0
21.746122917863296, 21.02125215393452

Remnants

--

e68

cso30:c:EntityBiological

cso30:i:CC_Extracellular

--

p92

--

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
171.0, 255.0
839.7237354966342, 1189.8668429177399

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
174.0, 276.0
805.5569854171277, 1169.6687428256696

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
179.0, 315.0
801.8791759029863, 1154.3288303559784

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
438.0, 430.0
19.0, 19.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000020434 e5

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c3 : 1
stoichiometry:c4 : 1
stoichiometry:c5 : 1

m4923*m5*0.1

nodelay

--

true

0

false

PMID: 15802263,12796777,12871942 The real ligand of Nod1 was characterized as PGN fragments that contain the dipeptide, D-gamma-glutamyl-meso- DAP (iE-DAP), which can either be generated by degradation of PGN or secreted by bacteria during replication

Go back
502.0, 666.0
19.0, 19.0

p10

p10

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e12 MO000016894

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c24 : 1
stoichiometry:c25 : 1
stoichiometry:c26 : 1

m12*m1812*0.1

nodelay

--

true

0

false

PMID: 15802263 Nod1 and RICK also activate the MAPK-stimulated pathways JNK, Erk, and p38 that result in the activation of specific transcription factors, such as AP-1, SRF, and CREB

Go back
734.0, 678.0
19.0, 19.0

p10

p11

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e20 MO000000023

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c27 : 1
stoichiometry:c28 : 1
stoichiometry:c29 : 1

m21*m22*0.1

nodelay

--

true

0

false

PMID: 15802263 Nod1 and RICK also activate the MAPK-stimulated pathways JNK, Erk, and p38 that result in the activation of specific transcription factors, such as AP-1, SRF, and CREB

Go back
654.0, 750.0
19.0, 19.0

p10

p12

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e20 MO000000011

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c30 : 1
stoichiometry:c31 : 1
stoichiometry:c32 : 1

m21*m24*0.1

nodelay

--

true

0

false

PMID: 15802263 Nod1 and RICK also activate the MAPK-stimulated pathways JNK, Erk, and p38 that result in the activation of specific transcription factors, such as AP-1, SRF, and CREB

Go back
714.0, 722.0
19.0, 19.0

p10

p13

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e20 MO000000022

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c33 : 1
stoichiometry:c34 : 1
stoichiometry:c35 : 1

m21*m26*0.1

nodelay

--

true

0

false

PMID: 15802263 Nod1 and RICK also activate the MAPK-stimulated pathways JNK, Erk, and p38 that result in the activation of specific transcription factors, such as AP-1, SRF, and CREB

Go back
654.0, 958.0
19.0, 19.0

p10

p14

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e22 MO000000276

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c36 : 1
stoichiometry:c37 : 1

m25*m219*0.1

nodelay

--

true

0

false

PMID: 15802263 Nod1 and RICK also activate the MAPK-stimulated pathways JNK, Erk, and p38 that result in the activation of specific transcription factors, such as AP-1, SRF, and CREB

Go back
922.0, 846.0
19.0, 19.0

p10

p15

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e23 MO000000276

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c39 : 1
stoichiometry:c40 : 1

m27*m219*0.1

nodelay

--

true

0

false

PMID: 15802263 Nod1 and RICK also activate the MAPK-stimulated pathways JNK, Erk, and p38 that result in the activation of specific transcription factors, such as AP-1, SRF, and CREB

Go back
830.0, 782.0
19.0, 19.0

p10

p16

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e21 MO000000276

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c41 : 1
stoichiometry:c42 : 1
stoichiometry:c43 : 1

m23*m219*0.1

nodelay

--

true

0

false

PMID: 15802263 Nod1 and RICK also activate the MAPK-stimulated pathways JNK, Erk, and p38 that result in the activation of specific transcription factors, such as AP-1, SRF, and CREB

Go back
690.0, 874.0
19.0, 19.0

p10

p17

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e22 e24

MO000000059

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c45 : 1
stoichiometry:c46 : 1

m25*m29*0.1

nodelay

--

true

0

false

PMID: 15802263 Nod1 and RICK also activate the MAPK-stimulated pathways JNK, Erk, and p38 that result in the activation of specific transcription factors, such as AP-1, SRF, and CREB

Go back
770.0, 1006.0
19.0, 19.0

p10

p18

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e23 e24

MO000000059

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c48 : 1
stoichiometry:c49 : 1

m27*m29*0.1

nodelay

--

true

0

false

PMID: 15802263 Nod1 and RICK also activate the MAPK-stimulated pathways JNK, Erk, and p38 that result in the activation of specific transcription factors, such as AP-1, SRF, and CREB

Go back
758.0, 778.0
19.0, 19.0

p10

p19

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e21 e24

MO000000059

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c51 : 1
stoichiometry:c52 : 1

m23*m29*0.1

nodelay

--

true

0

false

PMID: 15802263 Nod1 and RICK also activate the MAPK-stimulated pathways JNK, Erk, and p38 that result in the activation of specific transcription factors, such as AP-1, SRF, and CREB

Go back
502.0, 334.0
19.0, 19.0

p2

p2

cso30:i:ME_UnknownDegradation

cso30:i:CC_Extracellular

--

MO000042032

e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1

m155701*0.1

nodelay

--

true

0

false

PMID: 15802263,12796777,12871942 The real ligand of Nod1 was characterized as PGN fragments that contain the dipeptide, D-gamma-glutamyl-meso- DAP (iE-DAP), which can either be generated by degradation of PGN or secreted by bacteria during replication

Go back
850.0, 886.0
19.0, 19.0

p10

p20

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e21 e25

MO000017189

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c53 : 1
stoichiometry:c54 : 1
stoichiometry:c55 : 1

m23*m30*0.1

nodelay

--

true

0

false

PMID: 15802263 Nod1 and RICK also activate the MAPK-stimulated pathways JNK, Erk, and p38 that result in the activation of specific transcription factors, such as AP-1, SRF, and CREB

Go back
746.0, 858.0
19.0, 19.0

p10

p21

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e23 e25

MO000017189

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c57 : 1
stoichiometry:c58 : 1

m27*m30*0.1

nodelay

--

true

0

false

PMID: 15802263 Nod1 and RICK also activate the MAPK-stimulated pathways JNK, Erk, and p38 that result in the activation of specific transcription factors, such as AP-1, SRF, and CREB

Go back
694.0, 958.0
19.0, 19.0

p10

p22

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e22 e25

MO000017189

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c60 : 1
stoichiometry:c61 : 1

m25*m30*0.1

nodelay

--

true

0

false

PMID: 15802263 Nod1 and RICK also activate the MAPK-stimulated pathways JNK, Erk, and p38 that result in the activation of specific transcription factors, such as AP-1, SRF, and CREB

Go back
278.0, 962.0
19.0, 19.0

p23

p23

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010262

MO000007384

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c63 : 1
stoichiometry:c64 : 1

m93248*0.1

nodelay

--

true

0

false

PMID: 15802263 Figure2 PMID: 15802263 Once released from its inhibitor IKappaBalpha, the transcription factor NF-KappaB translocates to the nucleus and initiates the transcription of proinflammatory genes.

Go back
414.0, 1082.0
19.0, 19.0

p9

p24

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e18

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c66 : 1

m19*0.1

nodelay

--

true

0

false

PMID: 15802263 Once released from its inhibitor IKappaBalpha, the transcription factor NF-KappaB translocates to the nucleus and initiates the transcription of proinflammatory genes. PMID: 15802263 Figure2

Go back
242.0, 1054.0
19.0, 19.0

p23

p25

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e26

MO000017264

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c68 : 1

m31*0.1

nodelay

--

true

0

false

PMID: 15802263 Figure2 PMID: 15802263 Once released from its inhibitor IKappaBalpha, the transcription factor NF-KappaB translocates to the nucleus and initiates the transcription of proinflammatory genes.

Go back
450.0, 1130.0
19.0, 19.0

p9

p26

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e18

G010329

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c70 : 1

m19*0.1

nodelay

--

true

0

false

PMID: 15802263 Once released from its inhibitor IKappaBalpha, the transcription factor NF-KappaB translocates to the nucleus and initiates the transcription of proinflammatory genes. PMID: 15802263 Figure2

Go back
234.0, 1146.0
19.0, 19.0

p23

p27

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010329

MO000000289

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c71 : 1
stoichiometry:c72 : 1

m93309*0.1

nodelay

--

true

0

false

PMID: 15802263 Figure2 PMID: 15802263 Once released from its inhibitor IKappaBalpha, the transcription factor NF-KappaB translocates to the nucleus and initiates the transcription of proinflammatory genes.

Go back
466.0, 1166.0
19.0, 19.0

p9

p28

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e18

G010815

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c75 : 1

m19*0.1

nodelay

--

true

0

false

PMID: 15802263 Once released from its inhibitor IKappaBalpha, the transcription factor NF-KappaB translocates to the nucleus and initiates the transcription of proinflammatory genes. PMID: 15802263 Figure2

Go back
238.0, 1206.0
19.0, 19.0

p23

p29

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010815

MO000017280

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c74 : 1

m93710*0.1

nodelay

--

true

0

false

PMID: 15802263 Figure2 PMID: 15802263 Once released from its inhibitor IKappaBalpha, the transcription factor NF-KappaB translocates to the nucleus and initiates the transcription of proinflammatory genes.

Go back
351.0, 551.0
17.0, 17.0

p3

p3

cso30:i:ME_Oligomerization

cso30:i:CC_Cytosol

--

e6

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c6 : 1
stoichiometry:c7 : 1

m6*0.1

nodelay

--

true

0

false

PMID: 15802263,10880512 Nod1 activates NF-KappaB through recruitment and oligomerization of RICK (also called RIP2 or CARDIAK), which results in the activation of the IKK complex PMID: 15802263 Stimulation of cells with iE-DAP causes the oligomerization of Nod1 and recruitment of the protein kinase RICK.

Go back
502.0, 1014.0
19.0, 19.0

p9

p30

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

MO000000059

G010262

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c78 : 1

m28*0.1

nodelay

--

true

0

false

PMID: 15802263 Once released from its inhibitor IKappaBalpha, the transcription factor NF-KappaB translocates to the nucleus and initiates the transcription of proinflammatory genes. PMID: 15802263 Figure2

Go back
458.0, 962.0
19.0, 19.0

p9

p31

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

MO000017189

G010262

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c80 : 1

m2057*0.1

nodelay

--

true

0

false

PMID: 15802263 Once released from its inhibitor IKappaBalpha, the transcription factor NF-KappaB translocates to the nucleus and initiates the transcription of proinflammatory genes. PMID: 15802263 Figure2

Go back
246.0, 1266.0
19.0, 19.0

p23

p32

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e27

MO000019886

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c81 : 1

m32*0.1

nodelay

--

true

0

false

PMID: 15802263 Figure2 PMID: 15802263 Once released from its inhibitor IKappaBalpha, the transcription factor NF-KappaB translocates to the nucleus and initiates the transcription of proinflammatory genes.

Go back
522.0, 1150.0
19.0, 19.0

p9

p33

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e18

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c83 : 1

m19*0.1

nodelay

--

true

0

false

PMID: 15802263 Once released from its inhibitor IKappaBalpha, the transcription factor NF-KappaB translocates to the nucleus and initiates the transcription of proinflammatory genes. PMID: 15802263 Figure2

Go back
546.0, 1166.0
19.0, 19.0

p9

p34

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e18

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c85 : 1
stoichiometry:c86 : 1

m19*0.1

nodelay

--

true

0

false

PMID: 15802263 Once released from its inhibitor IKappaBalpha, the transcription factor NF-KappaB translocates to the nucleus and initiates the transcription of proinflammatory genes. PMID: 15802263 Figure2

Go back
594.0, 1402.0
19.0, 19.0

p23

p35

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e28

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c88 : 1

m33*0.1

nodelay

--

true

0

false

PMID: 15802263 Figure2 PMID: 15802263 Once released from its inhibitor IKappaBalpha, the transcription factor NF-KappaB translocates to the nucleus and initiates the transcription of proinflammatory genes.

Go back
578.0, 1142.0
19.0, 19.0

p9

p36

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e18

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c89 : 1
stoichiometry:c90 : 1

m19*0.1

nodelay

--

true

0

false

PMID: 15802263 Once released from its inhibitor IKappaBalpha, the transcription factor NF-KappaB translocates to the nucleus and initiates the transcription of proinflammatory genes. PMID: 15802263 Figure2

Go back
654.0, 1378.0
19.0, 19.0

p23

p37

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e30

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c91 : 1
stoichiometry:c92 : 1

m35*0.1

nodelay

--

true

0

false

PMID: 15802263 Figure2 PMID: 15802263 Once released from its inhibitor IKappaBalpha, the transcription factor NF-KappaB translocates to the nucleus and initiates the transcription of proinflammatory genes.

Go back
674.0, 1110.0
19.0, 19.0

p9

p38

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e18

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c94 : 1

m19*0.1

nodelay

--

true

0

false

PMID: 15802263 Once released from its inhibitor IKappaBalpha, the transcription factor NF-KappaB translocates to the nucleus and initiates the transcription of proinflammatory genes. PMID: 15802263 Figure2

Go back
726.0, 1342.0
19.0, 19.0

p23

p39

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e32

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c95 : 1
stoichiometry:c96 : 1

m37*0.1

nodelay

--

true

0

false

PMID: 15802263 Figure2 PMID: 15802263 Once released from its inhibitor IKappaBalpha, the transcription factor NF-KappaB translocates to the nucleus and initiates the transcription of proinflammatory genes.

Go back
425.0, 645.0
21.0, 21.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e11 MO000017949

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c8 : 1
stoichiometry:c9 : 1
stoichiometry:c10 : 1

m11*m2684*0.1

nodelay

--

true

0

false

PMID: 15802263 Stimulation of cells with iE-DAP causes the oligomerization of Nod1 and recruitment of the protein kinase RICK. PMID: 15802263,10880512 Nod1 activates NF-KappaB through recruitment and oligomerization of RICK (also called RIP2 or CARDIAK), which results in the activation of the IKK complex

Go back
522.0, 990.0
19.0, 19.0

p9

p40

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e19

G010262

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c97 : 1
stoichiometry:c98 : 1

m20*0.1

nodelay

--

true

0

false

PMID: 15802263 Once released from its inhibitor IKappaBalpha, the transcription factor NF-KappaB translocates to the nucleus and initiates the transcription of proinflammatory genes. PMID: 15802263 Figure2

Go back
390.0, 1030.0
19.0, 19.0

p9

p41

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

MO000000059

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c100 : 1

m28*0.1

nodelay

--

true

0

false

PMID: 15802263 Once released from its inhibitor IKappaBalpha, the transcription factor NF-KappaB translocates to the nucleus and initiates the transcription of proinflammatory genes. PMID: 15802263 Figure2

Go back
410.0, 1054.0
19.0, 19.0

p9

p42

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e19

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c101 : 1
stoichiometry:c102 : 1

m20*0.1

nodelay

--

true

0

false

PMID: 15802263 Once released from its inhibitor IKappaBalpha, the transcription factor NF-KappaB translocates to the nucleus and initiates the transcription of proinflammatory genes. PMID: 15802263 Figure2

Go back
354.0, 1118.0
19.0, 19.0

p9

p43

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

MO000017189

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c103 : 1
stoichiometry:c104 : 1

m2057*0.1

nodelay

--

true

0

false

PMID: 15802263 Once released from its inhibitor IKappaBalpha, the transcription factor NF-KappaB translocates to the nucleus and initiates the transcription of proinflammatory genes. PMID: 15802263 Figure2

Go back
310.0, 1102.0
19.0, 19.0

p9

p44

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

MO000000059

G010329

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c105 : 1
stoichiometry:c106 : 1

m28*0.1

nodelay

--

true

0

false

PMID: 15802263 Once released from its inhibitor IKappaBalpha, the transcription factor NF-KappaB translocates to the nucleus and initiates the transcription of proinflammatory genes. PMID: 15802263 Figure2

Go back
390.0, 1158.0
19.0, 19.0

p9

p45

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e19

G010329

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c107 : 1
stoichiometry:c108 : 1

m20*0.1

nodelay

--

true

0

false

PMID: 15802263 Once released from its inhibitor IKappaBalpha, the transcription factor NF-KappaB translocates to the nucleus and initiates the transcription of proinflammatory genes. PMID: 15802263 Figure2

Go back
406.0, 1126.0
19.0, 19.0

p9

p46

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

MO000017189

G010329

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c109 : 1
stoichiometry:c110 : 1

m2057*0.1

nodelay

--

true

0

false

PMID: 15802263 Once released from its inhibitor IKappaBalpha, the transcription factor NF-KappaB translocates to the nucleus and initiates the transcription of proinflammatory genes. PMID: 15802263 Figure2

Go back
362.0, 1182.0
19.0, 19.0

p9

p47

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

MO000000059

G010815

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c111 : 1
stoichiometry:c112 : 1

m28*0.1

nodelay

--

true

0

false

PMID: 15802263 Once released from its inhibitor IKappaBalpha, the transcription factor NF-KappaB translocates to the nucleus and initiates the transcription of proinflammatory genes. PMID: 15802263 Figure2

Go back
434.0, 1190.0
19.0, 19.0

p9

p48

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e19

G010815

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c113 : 1
stoichiometry:c114 : 1

m20*0.1

nodelay

--

true

0

false

PMID: 15802263 Once released from its inhibitor IKappaBalpha, the transcription factor NF-KappaB translocates to the nucleus and initiates the transcription of proinflammatory genes. PMID: 15802263 Figure2

Go back
402.0, 1218.0
19.0, 19.0

p9

p49

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

MO000017189

G010815

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c115 : 1
stoichiometry:c116 : 1

m2057*0.1

nodelay

--

true

0

false

PMID: 15802263 Once released from its inhibitor IKappaBalpha, the transcription factor NF-KappaB translocates to the nucleus and initiates the transcription of proinflammatory genes. PMID: 15802263 Figure2

Go back
450.0, 742.0
19.0, 19.0

p5

p5

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e12 e13

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c11 : 1
stoichiometry:c12 : 1
stoichiometry:c13 : 1

m12*m13*0.1

nodelay

--

true

0

false

PMID: 15802263,10880512 Nod1 activates NF-KappaB through recruitment and oligomerization of RICK (also called RIP2 or CARDIAK), which results in the activation of the IKK complex

Go back
458.0, 1218.0
19.0, 19.0

p9

p50

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

MO000000059

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c117 : 1
stoichiometry:c118 : 1

m28*0.1

nodelay

--

true

0

false

PMID: 15802263 Once released from its inhibitor IKappaBalpha, the transcription factor NF-KappaB translocates to the nucleus and initiates the transcription of proinflammatory genes. PMID: 15802263 Figure2

Go back
458.0, 1266.0
19.0, 19.0

p9

p51

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e19

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c119 : 1
stoichiometry:c120 : 1

m20*0.1

nodelay

--

true

0

false

PMID: 15802263 Once released from its inhibitor IKappaBalpha, the transcription factor NF-KappaB translocates to the nucleus and initiates the transcription of proinflammatory genes. PMID: 15802263 Figure2

Go back
490.0, 1294.0
19.0, 19.0

p9

p52

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

MO000017189

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c121 : 1
stoichiometry:c122 : 1

m2057*0.1

nodelay

--

true

0

false

PMID: 15802263 Once released from its inhibitor IKappaBalpha, the transcription factor NF-KappaB translocates to the nucleus and initiates the transcription of proinflammatory genes. PMID: 15802263 Figure2

Go back
534.0, 1222.0
19.0, 19.0

p9

p53

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

MO000000059

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c123 : 1
stoichiometry:c124 : 1

m28*0.1

nodelay

--

true

0

false

PMID: 15802263 Once released from its inhibitor IKappaBalpha, the transcription factor NF-KappaB translocates to the nucleus and initiates the transcription of proinflammatory genes. PMID: 15802263 Figure2

Go back
614.0, 1190.0
19.0, 19.0

p9

p54

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e19

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c125 : 1
stoichiometry:c126 : 1

m20*0.1

nodelay

--

true

0

false

PMID: 15802263 Once released from its inhibitor IKappaBalpha, the transcription factor NF-KappaB translocates to the nucleus and initiates the transcription of proinflammatory genes. PMID: 15802263 Figure2

Go back
586.0, 1106.0
19.0, 19.0

p9

p55

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

MO000017189

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c127 : 1
stoichiometry:c128 : 1

m2057*0.1

nodelay

--

true

0

false

PMID: 15802263 Once released from its inhibitor IKappaBalpha, the transcription factor NF-KappaB translocates to the nucleus and initiates the transcription of proinflammatory genes. PMID: 15802263 Figure2

Go back
626.0, 1246.0
19.0, 19.0

p9

p56

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

MO000000059

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c129 : 1
stoichiometry:c130 : 1

m28*0.1

nodelay

--

true

0

false

PMID: 15802263 Once released from its inhibitor IKappaBalpha, the transcription factor NF-KappaB translocates to the nucleus and initiates the transcription of proinflammatory genes. PMID: 15802263 Figure2

Go back
650.0, 1258.0
19.0, 19.0

p9

p57

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e19

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c131 : 1
stoichiometry:c132 : 1

m20*0.1

nodelay

--

true

0

false

PMID: 15802263 Once released from its inhibitor IKappaBalpha, the transcription factor NF-KappaB translocates to the nucleus and initiates the transcription of proinflammatory genes. PMID: 15802263 Figure2

Go back
586.0, 1230.0
19.0, 19.0

p9

p58

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

MO000017189

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c133 : 1
stoichiometry:c134 : 1

m2057*0.1

nodelay

--

true

0

false

PMID: 15802263 Once released from its inhibitor IKappaBalpha, the transcription factor NF-KappaB translocates to the nucleus and initiates the transcription of proinflammatory genes. PMID: 15802263 Figure2

Go back
706.0, 1202.0
19.0, 19.0

p9

p59

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e19

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c135 : 1
stoichiometry:c136 : 1

m20*0.1

nodelay

--

true

0

false

PMID: 15802263 Once released from its inhibitor IKappaBalpha, the transcription factor NF-KappaB translocates to the nucleus and initiates the transcription of proinflammatory genes. PMID: 15802263 Figure2

Go back
434.0, 786.0
19.0, 19.0

p6

p6

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e14 e15

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c14 : 1
stoichiometry:c15 : 1
stoichiometry:c16 : 1

m14*m15*0.1

nodelay

--

true

0

false

PMID: 15802263 RICK activates the IKK complex, which then phosphorylates (P) IKappaBalpha, signaling its degradation by the proteasome.

Go back
726.0, 1170.0
19.0, 19.0

p9

p60

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

MO000017189

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c137 : 1
stoichiometry:c138 : 1

m2057*0.1

nodelay

--

true

0

false

PMID: 15802263 Once released from its inhibitor IKappaBalpha, the transcription factor NF-KappaB translocates to the nucleus and initiates the transcription of proinflammatory genes. PMID: 15802263 Figure2

Go back
666.0, 1186.0
19.0, 19.0

p9

p61

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

MO000000059

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c139 : 1
stoichiometry:c140 : 1

m28*0.1

nodelay

--

true

0

false

PMID: 15802263 Once released from its inhibitor IKappaBalpha, the transcription factor NF-KappaB translocates to the nucleus and initiates the transcription of proinflammatory genes. PMID: 15802263 Figure2

Go back
462.0, 1302.0
19.0, 19.0

p9

p62

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e18

G010514

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c144 : 1
stoichiometry:c143 : 1

m19*0.1

nodelay

--

true

0

false

PMID: 15802263 Once released from its inhibitor IKappaBalpha, the transcription factor NF-KappaB translocates to the nucleus and initiates the transcription of proinflammatory genes. PMID: 15802263 Figure2

Go back
302.0, 1342.0
19.0, 19.0

p23

p63

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010514

MO000021201

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c141 : 1
stoichiometry:c142 : 1

m93479*0.1

nodelay

--

true

0

false

PMID: 15802263 Figure2 PMID: 15802263 Once released from its inhibitor IKappaBalpha, the transcription factor NF-KappaB translocates to the nucleus and initiates the transcription of proinflammatory genes.

Go back
434.0, 1250.0
19.0, 19.0

p9

p64

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

MO000017189

G010514

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c145 : 1
stoichiometry:c146 : 1

m2057*0.1

nodelay

--

true

0

false

PMID: 15802263 Once released from its inhibitor IKappaBalpha, the transcription factor NF-KappaB translocates to the nucleus and initiates the transcription of proinflammatory genes. PMID: 15802263 Figure2

Go back
494.0, 1266.0
19.0, 19.0

p9

p65

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

MO000000059

G010514

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c147 : 1
stoichiometry:c148 : 1

m28*0.1

nodelay

--

true

0

false

PMID: 15802263 Once released from its inhibitor IKappaBalpha, the transcription factor NF-KappaB translocates to the nucleus and initiates the transcription of proinflammatory genes. PMID: 15802263 Figure2

Go back
526.0, 1306.0
19.0, 19.0

p9

p66

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e19

G010514

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c149 : 1
stoichiometry:c150 : 1

m20*0.1

nodelay

--

true

0

false

PMID: 15802263 Once released from its inhibitor IKappaBalpha, the transcription factor NF-KappaB translocates to the nucleus and initiates the transcription of proinflammatory genes. PMID: 15802263 Figure2

Go back
366.0, 1382.0
19.0, 19.0

p23

p67

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G029941

MO000017266

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c152 : 1
stoichiometry:c151 : 1

m108639*0.1

nodelay

--

true

0

false

PMID: 15802263 Figure2 PMID: 15802263 Once released from its inhibitor IKappaBalpha, the transcription factor NF-KappaB translocates to the nucleus and initiates the transcription of proinflammatory genes.

Go back
506.0, 1342.0
19.0, 19.0

p9

p68

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e18 e19

G029941

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c153 : 1
stoichiometry:c157 : 1
stoichiometry:c154 : 1

m19*m20*0.1

nodelay

--

true

0

false

PMID: 15802263 Once released from its inhibitor IKappaBalpha, the transcription factor NF-KappaB translocates to the nucleus and initiates the transcription of proinflammatory genes. PMID: 15802263 Figure2

Go back
482.0, 1330.0
19.0, 19.0

p9

p69

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

MO000000059

G029941

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c155 : 1
stoichiometry:c156 : 1

m28*0.1

nodelay

--

true

0

false

PMID: 15802263 Once released from its inhibitor IKappaBalpha, the transcription factor NF-KappaB translocates to the nucleus and initiates the transcription of proinflammatory genes. PMID: 15802263 Figure2

Go back
454.0, 866.0
19.0, 19.0

p7

p7

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

e16

e17 MO000000058

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c17 : 1
stoichiometry:c18 : 1
stoichiometry:c19 : 1

m16*0.1

nodelay

--

true

0

false

PMID: 15802263 RICK activates the IKK complex, which then phosphorylates (P) IKappaBalpha, signaling its degradation by the proteasome.

Go back
494.0, 1370.0
19.0, 19.0

p9

p70

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e19

G029941

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c158 : 1
stoichiometry:c159 : 1

m20*0.1

nodelay

--

true

0

false

PMID: 15802263 Once released from its inhibitor IKappaBalpha, the transcription factor NF-KappaB translocates to the nucleus and initiates the transcription of proinflammatory genes. PMID: 15802263 Figure2

Go back
498.0, 1230.0
19.0, 19.0

p9

p71

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

MO000017189

G029941

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c162 : 1
stoichiometry:c163 : 1

m2057*0.1

nodelay

--

true

0

false

PMID: 15802263 Once released from its inhibitor IKappaBalpha, the transcription factor NF-KappaB translocates to the nucleus and initiates the transcription of proinflammatory genes. PMID: 15802263 Figure2

Go back
593.0, 1129.5
NaN, NaN

p72

p72

cso30:i:-

cso30:i:CC_CellComponent

--

MO000017189

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c161 : 1
stoichiometry:c160 : 1

m2057*0.1

nodelay

--

true

0

false

--

Go back
609.0, 385.0
21.0, 21.0

p73

p73

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000020461 MO000042032

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c165 : 1
stoichiometry:c164 : 1
stoichiometry:c166 : 1

m4947*m155701*0.1

nodelay

--

true

0

false

PMID: 15802263 The specific moiety of PGN that stimulates Nod2 activity is MDP PMID: 15802263,12871942,12514169,12791997 MDP is a common component of almost all types of PGN, indicating that Nod2 acts as a general sensor of PGN

Go back
482.0, 450.0
19.0, 19.0

p74

p74

cso30:i:ME_Oligomerization

cso30:i:CC_Cytosol

--

e35

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c167 : 1
stoichiometry:c168 : 1

m40*0.1

nodelay

--

true

0

false

--

Go back
506.0, 534.0
19.0, 19.0

p75

p75

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e34 MO000017949

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c169 : 1
stoichiometry:c170 : 1
stoichiometry:c171 : 1

m39*m2684*0.1

nodelay

--

true

0

false

PMID: 15802263,12791997 Once activated by MDP, Nod2 activates downstream inflammatory signaling pathways through RICK PMID: 15802263 Nod2 is activated by MDP stimulation of cells and, like Nod1, oligomerizes and recruits RICK, which activates the IKK complex and stimulates NF-KappaB activation by ubiquitinylation (Ub) of the IKKgamma subunit of the IKK complex.

Go back
718.0, 574.0
19.0, 19.0

p76

p76

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e36 e13

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c172 : 1
stoichiometry:c173 : 1
stoichiometry:c174 : 1

m41*m13*0.1

nodelay

--

true

0

false

PMID: 15802263 Nod2 is activated by MDP stimulation of cells and, like Nod1, oligomerizes and recruits RICK, which activates the IKK complex and stimulates NF-KappaB activation by ubiquitinylation (Ub) of the IKKgamma subunit of the IKK complex.

Go back
371.0, 847.0
18.0, 18.0

p77

p77

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e14

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c175 : 1
stoichiometry:c176 : 1

m14*0.1

nodelay

--

true

0

false

PMID: 15802263 Nod2 is activated by MDP stimulation of cells and, like Nod1, oligomerizes and recruits RICK, which activates the IKK complex and stimulates NF-KappaB activation by ubiquitinylation (Ub) of the IKKgamma subunit of the IKK complex.

Go back
385.0, 913.0
17.0, 17.0

p78

p78

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e37 e38

MO000000058

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c177 : 1
stoichiometry:c178 : 1
stoichiometry:c179 : 1

m42*m43*0.1

nodelay

--

true

0

false

PMID: 15802263 Nod2 is activated by MDP stimulation of cells and, like Nod1, oligomerizes and recruits RICK, which activates the IKK complex and stimulates NF-KappaB activation by ubiquitinylation (Ub) of the IKKgamma subunit of the IKK complex.

Go back
562.0, 610.0
19.0, 19.0

p79

p79

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e36 MO000016894

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c180 : 1
stoichiometry:c181 : 1
stoichiometry:c182 : 1

m41*m1812*0.1

nodelay

--

true

0

false

PMID: 15802263 Nod2 also activates the MAPK pathway upon stimulation.

Go back
598.0, 938.0
19.0, 19.0

p8

p8

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

MO000000058

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c20 : 1
stoichiometry:c21 : 1

m18*0.1

nodelay

--

true

0

false

PMID: 15802263 Once released from its inhibitor IKappaBalpha, the transcription factor NF-KappaB translocates to the nucleus and initiates the transcription of proinflammatory genes.

Go back
762.0, 406.0
19.0, 19.0

p80

p80

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000116924 e39

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c183 : 1
stoichiometry:c184 : 1
stoichiometry:c185 : 1

m86033*m44*0.1

nodelay

--

true

0

false

PMID: 15802263 Activation of cryopyrin by its proposed ligand, MDP, causes the formation of a complex composed of cryopyrin, ASC, CARD8, and caspase-1, which activates the IKK complex and NF-KappaB signaling, as well as induces maturation and secretion of pro-IL-1beta and pro-IL-18 through proteolytic cleavage by caspase-1.

Go back
622.0, 1006.0
19.0, 19.0

p81

p81

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e41

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c186 : 1
stoichiometry:c187 : 1

m46*0.1

nodelay

--

true

0

false

PMID: 15802263,15163405 Cryopyrin is the protein product of the gene CIAS1, which is mutated in several hereditary fever syndromes and is expressed primarily in polymorphonuclear cells and chondrocytes

Go back
586.0, 766.0
19.0, 19.0

p82

p82

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e42

MO000116924

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c188 : 1
stoichiometry:c189 : 1

m47*0.1

nodelay

--

true

0

false

PMID: 15802263,15163405 Cryopyrin is the protein product of the gene CIAS1, which is mutated in several hereditary fever syndromes and is expressed primarily in polymorphonuclear cells and chondrocytes

Go back
806.0, 470.0
19.0, 19.0

p80

p83

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e40 MO000044014 MO000061612 MO000016828

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c190 : 1
stoichiometry:c192 : 1
stoichiometry:c193 : 1
stoichiometry:c194 : 1
stoichiometry:c191 : 1

m45*m21736*m36509*m1765*0.1

nodelay

--

true

0

false

PMID: 15802263 Activation of cryopyrin by its proposed ligand, MDP, causes the formation of a complex composed of cryopyrin, ASC, CARD8, and caspase-1, which activates the IKK complex and NF-KappaB signaling, as well as induces maturation and secretion of pro-IL-1beta and pro-IL-18 through proteolytic cleavage by caspase-1.

Go back
750.0, 598.0
19.0, 19.0

p84

p84

cso30:i:ME_UnknownActivation

cso30:i:CC_Extracellular

--

e43 e13

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c195 : 1
stoichiometry:c196 : 1
stoichiometry:c197 : 1

m48*m13*0.1

nodelay

--

true

0

false

PMID: 15802263 Activation of cryopyrin by its proposed ligand, MDP, causes the formation of a complex composed of cryopyrin, ASC, CARD8, and caspase-1, which activates the IKK complex and NF-KappaB signaling, as well as induces maturation and secretion of pro-IL-1beta and pro-IL-18 through proteolytic cleavage by caspase-1 PMID: 15802263 Figure 2

Go back
898.0, 558.0
19.0, 19.0

p85

p85

cso30:i:ME_Cleavage

cso30:i:CC_Extracellular

--

e43 MO000019449

MO000016597

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c198 : 1
stoichiometry:c199 : 1
stoichiometry:c200 : 1

m48*m4012*0.1

nodelay

--

true

0

false

PMID: 15802263 Activation of cryopyrin by its proposed ligand, MDP, causes the formation of a complex composed of cryopyrin, ASC, CARD8, and caspase-1, which activates the IKK complex and NF-KappaB signaling, as well as induces maturation and secretion of pro-IL-1beta and pro-IL-18 through proteolytic cleavage by caspase-1

Go back
794.0, 634.0
19.0, 19.0

p85

p86

cso30:i:ME_Cleavage

cso30:i:CC_Extracellular

--

e43 MO000007330

MO000016625

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c201 : 1
stoichiometry:c202 : 1
stoichiometry:c203 : 1

m48*m841*0.1

nodelay

--

true

0

false

PMID: 15802263 Activation of cryopyrin by its proposed ligand, MDP, causes the formation of a complex composed of cryopyrin, ASC, CARD8, and caspase-1, which activates the IKK complex and NF-KappaB signaling, as well as induces maturation and secretion of pro-IL-1beta and pro-IL-18 through proteolytic cleavage by caspase-1

Go back
117.0, 249.0
21.0, 21.0

p87

p87

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e44 MO000019397

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c204 : 1
stoichiometry:c205 : 1
stoichiometry:c206 : 1

m49*m3964*0.1

nodelay

--

true

0

false

PMID: 15802263,15359270 The results from this study demonstrated that TLR2 is not a sensor for PGN but is activated by the lipoproteins and lipoteichoic acids that are commonly present in these commercial PGN preparations

Go back
89.0, 373.0
21.0, 21.0

p87

p88

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019397 e46

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c207 : 1
stoichiometry:c208 : 1
stoichiometry:c209 : 1

m3964*m64*0.1

nodelay

--

true

0

false

PMID: 15802263,15359270 The results from this study demonstrated that TLR2 is not a sensor for PGN but is activated by the lipoproteins and lipoteichoic acids that are commonly present in these commercial PGN preparations

Go back
459.0, 135.0
17.0, 17.0

p89

p89

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e48 e49

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c210 : 1
stoichiometry:c211 : 1
stoichiometry:c212 : 1

m66*m67*0.1

nodelay

--

true

0

false

PMID: 15802263 All mammalian PGRPs have been shown to be secreted proteins and to bind directly to PGN as well as live bacteria.

Go back
450.0, 1030.0
19.0, 19.0

p9

p9

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e18

G010262

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c62 : 1

m19*0.1

nodelay

--

true

0

false

PMID: 15802263 Once released from its inhibitor IKappaBalpha, the transcription factor NF-KappaB translocates to the nucleus and initiates the transcription of proinflammatory genes. PMID: 15802263 Figure2

Go back
335.0, 119.0
17.0, 17.0

p89

p90

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e64 e48

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c213 : 1
stoichiometry:c214 : 1
stoichiometry:c215 : 1

m69*m66*0.1

nodelay

--

true

0

false

PMID: 15802263 All mammalian PGRPs have been shown to be secreted proteins and to bind directly to PGN as well as live bacteria.

Go back
626.0, 158.0
19.0, 19.0

p91

p91

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e49 e66

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c216 : 1
stoichiometry:c217 : 1
stoichiometry:c218 : 1

m67*m71*0.1

nodelay

--

true

0

false

PMID: 15802263 PGRP-L binds to the muramyl tripeptide moiety in PGN and cleaves between the muramic acid and the first amino acid of the stem peptide chain, L-alanine PMID: 15802263,6120007,8605233 This specificity is identical to the PGN degradation enzyme, serum N-acetylmuramoyl-L-alanine amidase, leading investigators to conclude that they are the same enzyme

Go back
774.0, 198.0
19.0, 19.0

p92

p92

cso30:i:ME_Cleavage

cso30:i:CC_Extracellular

--

e67

e68 e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c219 : 1
stoichiometry:c220 : 1
stoichiometry:c221 : 1

m72*0.1

nodelay

--

true

0

false

PMID: 15802263 PGRP-L binds to the muramyl tripeptide moiety in PGN and cleaves between the muramic acid and the first amino acid of the stem peptide chain, L-alanine PMID: 15802263,6120007,8605233 This specificity is identical to the PGN degradation enzyme, serum N-acetylmuramoyl-L-alanine amidase, leading investigators to conclude that they are the same enzyme

Go back
404.0, 340.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
323.599458978568, 664.0

c10

c10

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
353.46238507524475, 1044.0

c100

c100

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
436.8698620396639, 1067.4371052420256

c101

c101

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
353.9912253949587, 1064.0

c102

c102

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
380.8102793580676, 1022.0

c103

c103

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
338.0414336125515, 1083.9041157547754

c104

c104

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
336.9864408721985, 1085.0

c105

c105

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
320.0, 1121.0

c106

c106

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
416.99555925583326, 1152.0

c107

c107

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
337.99001871102274, 1169.0

c108

c108

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
432.73080185007, 1023.0

c109

c109

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
317.0, 744.0

c11

c11

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
337.50674493453687, 1140.0

c110

c110

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
388.735068310439, 1086.0

c111

c111

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
350.4854338271991, 1199.0

c112

c112

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
460.95584342563626, 1153.0

c113

c113

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
351.8765000622873, 1202.0

c114

c114

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
428.2326988178866, 1025.0

c115

c115

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
351.95753435061243, 1221.823193208684

c116

c116

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
484.2779051296022, 1088.0

c117

c117

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
417.0343357322942, 1234.0

c118

c118

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
484.6907811747055, 1155.0

c119

c119

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
476.7685735448304, 735.0

c12

c12

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
417.9930645847388, 1273.3330443576974

c120

c120

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
515.2231780811528, 1028.0

c121

c121

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
417.68855443143906, 1280.2104593990387

c122

c122

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
559.8216931327064, 1090.0

c123

c123

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
546.0, 1241.0

c124

c124

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
640.8843911260781, 1154.0

c125

c125

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
581.4766883796864, 1209.0

c126

c126

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
612.4893339666595, 1024.0

c127

c127

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
577.6736551832275, 1125.0

c128

c128

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
650.225866052374, 1093.0

c129

c129

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
321.7048877920229, 755.0

c13

c13

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
637.0, 1265.0

c130

c130

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
676.1942283523663, 1157.0

c131

c131

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
649.3861999450876, 1277.0

c132

c132

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
611.0758620907509, 1029.0

c133

c133

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
601.0, 1249.0

c134

c134

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
732.6123554101047, 1156.0

c135

c135

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
713.4990262892414, 1221.0

c136

c136

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
747.7108641494452, 1030.0

c137

c137

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
717.1659646153463, 1189.0

c138

c138

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
690.5643899042154, 1093.0

c139

c139

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
314.0, 796.0

c14

c14

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
681.0, 1205.0

c140

c140

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
328.32252025938215, 1326.0

c141

c141

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
270.5894663844041, 1338.5298221281348

c142

c142

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
404.96613343214375, 1313.0

c143

c143

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
477.42417907050265, 1085.0

c144

c144

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
459.8941065452937, 1026.0

c145

c145

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
402.65685424949237, 1269.0

c146

c146

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
519.5938036898496, 1090.0

c147

c147

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
404.52511936638064, 1280.0

c148

c148

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
552.2937842805469, 1157.0

c149

c149

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
461.0, 796.0

c15

c15

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
404.9961568483941, 1316.0

c150

c150

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
319.89115139065717, 1394.0

c151

c151

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
391.4985898687327, 1357.0

c152

c152

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
517.927553982626, 1085.0

c153

c153

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
455.9893198795369, 1349.4132406834244

c154

c154

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
507.01789166144096, 1092.0

c155

c155

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
455.9148730829188, 1341.0

c156

c156

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
532.0999686144139, 1158.0

c157

c157

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
519.9288710269124, 1158.0

c158

c158

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
455.27750403090425, 1357.322338796717

c159

c159

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
315.8356995595059, 802.0

c16

c16

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
413.7596359004996, 1141.0

c160

c160

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
621.2664709296508, 1025.0

c161

c161

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
523.7381712052921, 1026.0

c162

c162

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
448.4376015698018, 1249.0

c163

c163

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
404.0, 342.0

c164

c164

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
581.0, 357.0

c165

c165

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
596.0886031430172, 406.0

c166

c166

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
508.9930645847388, 457.0

c167

c167

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
501.0, 464.0

c168

c168

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
532.5684758930026, 516.0

c169

c169

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
309.0, 877.3857576427068

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
445.0, 547.1676869865141

c170

c170

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
525.0, 547.0

c171

c171

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
655.0, 585.758472741024

c172

c172

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
550.0, 596.9425724154552

c173

c173

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
321.1554175279993, 589.0

c174

c174

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
314.0, 804.0

c175

c175

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
338.7414442211778, 865.0

c176

c176

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
334.0, 924.0878401658401

c177

c177

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
400.9108042171238, 849.0

c178

c178

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
402.0, 917.319744306791

c179

c179

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
473.0, 859.6480838483988

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
588.4374520037236, 596.0

c180

c180

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
499.0, 613.0

c181

c181

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
581.0, 626.0

c182

c182

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
734.0, 357.0

c183

c183

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
787.1651621784848, 365.0

c184

c184

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
746.8989292741131, 425.0

c185

c185

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
614.0, 1032.5894663844042

c186

c186

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
588.8599434057004, 990.1159660434203

c187

c187

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
566.0, 792.8981513534244

c188

c188

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
599.0, 364.64542327396333

c189

c189

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
473.0, 881.0

c19

c19

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
746.0, 480.0

c190

c190

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
816.0, 489.0

c191

c191

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
823.2491077284276, 425.0

c192

c192

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
832.9021037226325, 470.0

c193

c193

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
831.7257215188587, 490.3318206392649

c194

c194

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
774.6568542494924, 562.0

c195

c195

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
550.0, 617.9088269514548

c196

c196

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
321.3946116796427, 612.0

c197

c197

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
826.0, 554.0

c198

c198

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
869.0, 582.4513482233507

c199

c199

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
512.0, 353.0

c2

c2

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
553.0, 922.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
917.0, 568.0

c200

c200

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
806.0972244678028, 569.0

c201

c201

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
726.0, 645.8192003637919

c202

c202

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
813.0, 644.0

c203

c203

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
115.0, 277.7895054303714

c204

c204

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
136.4952317018953, 277.196065268608

c205

c205

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
138.0, 262.0

c206

c206

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
118.0, 384.0

c207

c207

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
100.0, 402.0

c208

c208

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
108.0, 394.0

c209

c209

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
557.5212577361842, 957.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
403.0, 151.03935083181491

c210

c210

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
484.0, 144.0

c211

c211

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
475.0, 152.0

c212

c212

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
312.0, 96.0

c213

c213

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
357.56916668859003, 141.74320314760843

c214

c214

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
309.84217130815114, 136.0

c215

c215

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
568.0, 147.0

c216

c216

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
629.0, 109.0

c217

c217

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
645.0, 174.0

c218

c218

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
709.0, 208.3688381328672

c219

c219

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
476.5183473879075, 1045.7339445046937

c22

c22

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
793.0, 180.57770876399965

c220

c220

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
646.5952062052854, 113.52805202153921

c221

c221

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
639.0, 851.0

c23

c23

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
317.0, 681.5421193831127

c24

c24

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
492.0, 623.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
521.0, 676.0

c26

c26

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
667.0, 678.0

c27

c27

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
760.9510698773889, 677.0

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
753.0, 691.0

c29

c29

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
393.0, 412.0

c3

c3

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
657.0, 687.0

c30

c30

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
607.0, 719.0

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
643.8244580194739, 769.0

c32

c32

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
667.0, 685.0

c33

c33

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
740.9856387637262, 732.4791383258236

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
701.8372338729644, 741.0

c35

c35

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
621.0, 919.0

c36

c36

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
673.0, 975.0

c37

c37

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
705.0, 810.0

c38

c38

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
623.0, 859.2680451484258

c39

c39

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
464.1165361451483, 417.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
901.8644734461474, 865.0

c40

c40

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
854.1940990394277, 741.0

c41

c41

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
623.0, 800.6190090995574

c42

c42

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
841.0, 801.0

c43

c43

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
651.0, 847.0

c44

c44

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
716.4966569186612, 889.7928721853835

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
704.0, 893.0

c46

c46

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
700.0, 817.0

c47

c47

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
788.2785193715283, 937.0

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
780.0, 1025.0

c49

c49

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
356.9895084370238, 446.0

c5

c5

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
784.2876334417755, 736.0

c50

c50

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
773.8224311589584, 804.4855782911503

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
768.0, 797.0

c52

c52

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
863.5168063637899, 741.0

c53

c53

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
874.6568542494924, 910.6568542494924

c54

c54

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
853.4563983243081, 905.0

c55

c55

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
705.0, 817.0

c56

c56

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
772.1239456801213, 876.6399722453175

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
762.0, 877.0

c58

c58

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
643.0, 851.0

c59

c59

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
344.0, 513.0

c6

c6

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
720.9639637807517, 949.0

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
713.0, 971.0

c61

c61

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
420.037652108609, 1018.8041362749237

c62

c62

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
304.6144659505665, 977.4535501396269

c63

c63

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
142.96193414021292, 973.0

c64

c64

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
440.89115139065717, 1074.0

c65

c65

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
353.76114000116263, 1074.9402850002907

c66

c66

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
268.9850482685218, 1064.488880506236

c67

c67

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
146.9864610658899, 1065.0

c68

c68

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
475.33028001113735, 1082.0

c69

c69

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
331.9691115068547, 568.0

c7

c7

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
337.79072967793434, 1142.0

c70

c70

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
260.828398279894, 1159.6480838483988

c71

c71

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
135.0, 1156.0

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
487.5494543980792, 1085.0

c73

c73

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
137.99451867013414, 1216.0

c74

c74

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
351.6556672714286, 1179.0

c75

c75

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
264.9912253949587, 1216.3745886903887

c76

c76

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
528.8123804312969, 1027.7224145832781

c77

c77

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
420.91599903935696, 1011.1562695226027

c78

c78

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
484.93721530098867, 974.000306585878

c79

c79

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
332.0, 634.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
420.05882352941177, 977.0

c80

c80

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
143.0, 1276.0

c81

c81

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
535.4523798356488, 1085.0

c82

c82

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
409.32911015539435, 1168.0

c83

c83

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
272.99640242817895, 1273.0

c84

c84

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
549.0, 1085.0

c85

c85

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
557.0, 1185.0

c86

c86

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
581.0, 1358.0

c87

c87

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
587.3701422443754, 1421.0

c88

c88

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
554.0, 1085.0

c89

c89

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
436.0, 565.0

c9

c9

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
591.0, 1161.0

c90

c90

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
647.0, 1331.0

c91

c91

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
660.4697761756117, 1397.0

c92

c92

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
561.0, 1077.0

c93

c93

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
686.0, 1129.0

c94

c94

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
715.0, 1275.0

c95

c95

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
736.0, 1361.0

c96

c96

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
548.399624675038, 1007.0406503693403

c97

c97

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
420.98790728230443, 1001.0

c98

c98

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
416.94784057221034, 1041.9120472787783

c99

c99

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back